Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| crimean-congo hemorrhagic fever in european part of turkey: genetic analysis of the virus strains from ticks and a seroepidemiological study in humans. | abstract a survey of ticks from domestic ruminants, together with a serosurvey in humans was conducted in thrace (northwestern turkey) to evaluate the prevalence of crimean-congo hemorrhagic fever virus (cchfv) in ticks and humans. more prevalent ticks were hyalomma marginatum, hyalomma aegyptium, rhipicephalus bursa, and rhipicephalus (boophilus) annulatus, with low numbers of dermacentor marginatus, rhipicephalus sanguineus group, and ixodes ricinus. no differences in the tick faunal compositi ... | 2010 | 21028961 |
| complete sequence and phylogenetic characterisation of crimean-congo hemorrhagic fever virus from afghanistan. | 2010 | 21035389 | |
| effect of oral ribavirin treatment on the viral load and disease progression in crimean-congo hemorrhagic fever. | crimean-congo hemorrhagic fever (cchf) is a lethal hemorrhagic disease. there is currently no specific antiviral therapy for cchf approved for use in humans. in this study we aimed to investigate the effect of oral ribavirin treatment on the viral load and disease progression in cchf. | 2010 | 21106428 |
| detection of crimean-congo hemorrhagic fever, hanta, and sandfly fever viruses by real-time rt-pcr. | the development of sensitive and specific nucleic acid diagnostic assays for viral pathogens is essential for proper medical intervention. this chapter describes four fluorescence-based pcr assays to detect the crimean-congo hemorrhagic fever (cchfv), andes (andv), hantaan (hanv), and sandfly fever sicilian (sfsv) viruses. these assays are based on species-specific hydrolysis probes targeting the nucleocapsid protein gene for cchfv and sfsv and the glycoprotein gene for andv and hanv. all four a ... | 2011 | 21116810 |
| induction of caspase activation and cleavage of the viral nucleocapsid protein in different cell types during crimean-congo hemorrhagic fever virus infection. | regulation of apoptosis during infection has been observed for several viral pathogens. programmed cell death and regulation of apoptosis in response to a viral infection are important factors for host or virus survival. it is not known whether crimean-congo hemorrhagic fever virus (cchfv) infection regulates the apoptosis process in vitro. this study for the first time suggests that cchfv induces apoptosis, which may be dependent on caspase-3 activation. this study also shows that the coding se ... | 2010 | 21123175 |
| the bulgarian vaccine crimean-congo haemorrhagic fever virus strain. | the crimean-congo haemorrhagic fever virus (cchfv) is a 3-segmented rna virus, which causes disease with a high fatality rate in humans. an inactivated suckling mouse brain-derived vaccine is used in bulgaria for protection against cchf. strain v42/81 is currently used for the vaccine preparation. as the m-rna segment plays a major role in the immune response, the full-length m segment sequence of the v42/81 strain was characterized. a great genetic diversity was observed among cchfv strains. in ... | 2010 | 21142621 |
| phylogenetic analysis in a recent controlled outbreak of crimean-congo haemorrhagic fever in the south of iran, december 2008. | crimean-congo haemorrhagic fever (cchf) is a viral zoonotic disease with a high mortality rate in humans. the cchf virus is transmitted to humans through the bite of ixodid ticks or contact with blood or tissues of cchf patients or infected livestock. in december 2008, a re-emerging outbreak of cchf occurred in the southern part of iran. five people were hospitalised with sudden fever and haemorrhaging, and cchf was confirmed by rt-pcr and serological assays. one of the cases had a fulminant cou ... | 2010 | 21144440 |
| molecular epidemiology of crimean- congo hemorrhagic fever virus genome isolated from ticks of hamadan province of iran. | crimean-congo hemorrhagic fever (cchf) virus is a tick-borne member of the genus nairovirus, family bunyaviridae. cchfv has been isolated from at least 31 different tick species. the virus is transmitted through the bite of an infected tick, or by direct contact with cchfv-infected patients or the products of infected livestock. this study was undertaken to study the genetic relationship and distribution of cchfv in the tick population of hamadan province of iran. | 2010 | 21178213 |
| crimean-congo hemorrhagic fever virus, northeastern greece. | 2011 | 21192882 | |
| structural analysis of a viral ovarian tumor domain protease from the crimean-congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. | crimean-congo hemorrhagic fever (cchf) virus is a tick-borne, negative-sense, single-stranded rna [ssrna(-)] nairovirus that produces fever, prostration, and severe hemorrhages in humans. with fatality rates for cchf ranging up to 70% based on several factors, cchf is considered a dangerous emerging disease. originally identified in the former soviet union and the congo, cchf has rapidly spread across large sections of europe, asia, and africa. recent reports have identified a viral homologue of ... | 2011 | 21228232 |
| structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. | the attachment of ubiquitin (ub) and the ub-like (ubl) molecule interferon-stimulated gene 15 (isg15) to cellular proteins mediates important innate antiviral responses. ovarian tumor (otu) domain proteases from nairoviruses and arteriviruses were recently found to remove these molecules from host proteins, which inhibits ub and isg15-dependent antiviral pathways. this contrasts with the ub-specific activity of known eukaryotic otu-domain proteases. here we describe crystal structures of a viral ... | 2011 | 21245344 |
| molecular basis for ubiquitin and isg15 cross-reactivity in viral ovarian tumor domains. | crimean congo hemorrhagic fever virus (cchfv) is a deadly human pathogen that evades innate immune responses by efficiently interfering with antiviral signaling pathways mediated by nf-?b, irf3, and ifna/ß. these pathways rely on protein ubiquitination for their activation, and one outcome is the modification of proteins with the ubiquitin (ub)-like modifier interferon-stimulated gene (isg)15. cchfv and related viruses encode a deubiquitinase (dub) of the ovarian tumor (otu) family, which unlike ... | 2011 | 21266548 |
| newly recognized mosquito-associated viruses in mainland china, in the last two decades. | there are four principal arboviruses in mainland china. two kinds of them are mosquito-borne viruses, namely japanese encephalitis virus and dengue virus, which lead to japanese encephalitis, and dengue fever/dengue hemorrhagic fever respectively; the other two are tick-borne viruses, namely tick-borne encephalitis virus and crimean-congo hemorrhagic fever virus (also known as xinjiang hemorrhagic fever virus), which contribute to tick-borne encephalitis and xinjiang hemorrhagic fever respective ... | 2011 | 21314994 |
| species diversity of ixodid ticks feeding on humans in amasya, turkey: seasonal abundance and presence of crimean-congo hemorrhagic fever virus. | ticks (acari:ixodidae) are important pests transmitting tick-borne diseases such as crimean-congo hemorrhagic fever (cchf) to humans. between 2002 and 2009, numerous cchf cases were reported in turkey, including amasya province. in the current study, species diversity, seasonal abundance of ticks, and presence of cchf virus (cchfv) in ticks infesting humans in several districts of amasya province were determined. in the survey, a total of 2,528 ixodid ticks were collected from humans with tick b ... | 2011 | 21337953 |
| quantitative analysis of particles, genomes and infectious particles in supernatants of haemorrhagic fever virus cell cultures. | information on the replication of viral haemorrhagic fever viruses is not readily available and has never been analysed in a comparative approach. here, we compared the cell culture growth characteristics of haemorrhagic fever viruses (hfv), of the arenaviridae, filoviridae, bunyaviridae, and flavivridae virus families by performing quantitative analysis of cell culture supernatants by (i) electron microscopy for the quantification of virus particles, (ii) quantitative real time pcr for the quan ... | 2011 | 21349180 |
| crimean-congo hemorrhagic fever: current and future prospects of vaccines and therapies. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease caused by cchf virus (cchfv), a nairovirus in the family bunyaviridae. cchf occurs sporadically in a number of countries in asia, the middle east, southeastern europe and africa. patients may develop subclinical to severe hemorrhagic disease, with fatal outcomes in a substantial percentage of cases. transmission usually occurs through contact with viremic livestock or patients or bites by infected ticks. the number of reported cases ... | 2011 | 21362441 |
| [differentiation of genetic variants of crimean-congo hemorrhagic fever virus]. | the paper describes a simple, rapid screening of samples potentially containing crimean-congo hemorrhagic fever (cchf) virus strains, by applying the restriction analysis of amplicones, for the differentiation of cchf virus genotypes that are characteristic of europe from virus biovariants uncharacteristic of this area, this technique requiring no sequence at the first stage. for this screening, the authors propose to use the pcr fragment of cchf l segment that comprises a variable region, as we ... | 2011 | 21427952 |
| structural characterization of the crimean-congo hemorrhagic fever virus gn tail provides insight into virus assembly. | the rna virus that causes the crimean congo hemorrhagic fever (cchf) is a tick-borne pathogen of the nairovirus genus, family bunyaviridae. unlike many zoonotic viruses that are only passed between animals and humans, the cchf virus can also be transmitted from human to human with an overall mortality rate approaching 30%. currently, there are no atomic structures for any cchf virus proteins nor for any nairovirus proteins. a critical component of the virus is the envelope gn glycoprotein, which ... | 2011 | 21507948 |
| crimean-congo hemorrhagic fever disease due to tick bite with very long incubation periods. | background: crimean-congo hemorrhagic fever (cchf) is a zoonotic viral disease with a high mortality rate, and is one of the viral hemorrhagic fever syndromes. the average mortality rate of cchf is 3-30%. research indicates that the longest incubation period after a tick bite is 12 days in cchf disease. however, in clinical practice, we encounter patients with cchf as a result of tick bites with much longer incubation periods (max. 53 days) than those reported in the literature. we present herei ... | 2011 | 21511509 |
| [crimean-congo hemorrhagic fever: basics for general practitioners]. | crimean-congo hemorrhagic fever (cchf) is a tick-borne disease described in more than 30 countries in europe, asia and africa. the causative agent is the crimean-congo hemorrhagic fever virus (cchfv) that is a member of the genus nairovirus of the family bunyaviridae. cchfv that is characterized by a high genetic variability is transmitted to humans by tick bites or contact with fluids from an infected individual or animal. the initial symptoms of cchf are nonspecific and gradually progress to a ... | 2010 | 21520641 |
| epidemiological survey of crimean-congo hemorrhagic fever virus in yunnan, china, 2008. | objectives: we aimed to determine the seroprevalence of crimean-congo hemorrhagic fever virus (cchfv) infection in yunnan province, china. materials and methods: one thousand six hundred and fifty-seven human serum samples and 1280 ticks (hyalomma asiaticum) were collected from five counties (menglian, menghai, lancang, mengla, and ximeng). serum samples were analyzed independently by indirect immunofluorescence assay and western blotting to detected cchfv antibody. the ticks were examined by re ... | 2011 | 21546303 |
| a case of crimean-congo haemorrhagic fever successfully treated with therapeutic plasma exchange and ribavirin. | crimean-congo haemorrhagic fever (cchf) has become an important problem in certain parts of the world. cytokine storm plays a critical role in the pathogenesis of cchf. early diagnosis, supportive therapy and invasive monitoring are the cornerstones of the management of cchf. ribavirin is active against cchf virus in vitro, however, evidence of clinical efficacy is still conflicting. here, we describe a patient successfully recovered from cchf with a combination of plasma exchange and ribavirin ... | 2011 | 21565949 |
| inhibition of hazara nairovirus replication by small interfering rnas and their combination with ribavirin. | abstract: background: the genus nairovirus in the family bunyaviridae contains 34 tick-borne viruses classified into seven serogroups. hazara virus (hazv) belongs to the crimean-congo hemorrhagic fever (cchf) serogroup that also includes cchf virus (cchfv) a major pathogen for humans. hazv is an interesting model to study cchfv due to a close serological and phylogenetical relationship and a classification which allows handling in a bsl2 laboratory. nairoviruses are characterized by a tripartite ... | 2011 | 21600011 |
| crimean-congo hemorrhagic fever virus activates endothelial cells. | crimean-congo hemorrhagic fever virus (cchfv) causes viral hemorrhagic fever with high case fatality rates and is geographically widely distributed. . due to the requirement of a biosafety level 4 (bsl-4) laboratory and the lack of an animal model, the knowledge behind the pathogenesis of this virus is limited. crimean-congo hemorrhagic fever (cchf) is characterized by hemorrhage and vascular permeability indicating the involvement of endothelial cells in pathogenesis. the interplay between ecs ... | 2011 | 21632768 |
| multiple crimean-congo hemorrhagic fever virus strains are associated with disease outbreaks in sudan, 2008-2009. | crimean-congo hemorrhagic fever (cchf) activity has recently been detected in the kordufan region of sudan. since 2008, several sporadic cases and nosocomial outbreaks associated with high case-fatality have been reported in villages and rural hospitals in the region. | 2011 | 21655310 |
| a nosocomial transmission of crimean-congo hemorrhagic fever to an attending physician in north kordufan, sudan. | crimean-congo hemorrhagic fever (cchf), a tick-borne disease caused by crimean-congo hemorrhagic fever virus (cchfv), is a member of the genus nairovirus in the family bunyaviridae. recently, cchfv has been reported as an important emerging infectious viral pathogen in sudan. sporadic cases and multiple cchf outbreaks, associated with nosocomial chain of transmission, have been reported in the kordufan region of sudan. | 2011 | 21672268 |
| development of a one step real time rt-pcr assay to detect and quantify dugbe virus. | a one-step real time quantitative rt-pcr (qrt-pcr) assay was developed to detect all published dugbe virus (dugv) genomes of the nairovirus genus. primers and probes were designed to detect specific sequences on the most conserved regions of the s segment. the limit of detection of the assay was 10 copies per reaction which is an improvement of 3 log(10)ffu/ml over the sensitivity of conventional rt-pcr. the specificity of the primers and probe was confirmed with the closely related nairoviruses ... | 2011 | 21703306 |
| evaluation of knowledge about protection against crimean-congo hemorrhagic fever. | this study was conducted in order to evaluate individuals' knowledge about protection against crimean congo hemorrhagic fever (cchf). this descriptive study was carried out among 478 persons, to whom a family health center located within boundaries of erzurum metropolitan municipality, provides health service. a questionnaire form developed by the researchers was used for collecting data. seventy-one point eight percent of individuals who participated in the study stated they had knowledge about ... | 2011 | 21706954 |
| identification of a putative crimean-congo hemorrhagic fever virus entry factor. | entry of enveloped viruses into cells is initiated by binding of their envelope glycoproteins (envs) to cell surface-associated receptors. the crimean-congo hemorrhagic fever virus (cchfv) has two envs, gn and gc, with poorly understood role in binding to susceptible cells. we expressed codon optimized gn and gc, and identified independently folded soluble env fragments, one of which (gc residues 180-300) bound cchfv susceptible cells supposedly by interacting with a putative receptor. this rece ... | 2011 | 21723257 |
| crimean-congo hemorrhagic fever virus in ticks collected from humans, livestock, and picnic sites in the hyperendemic region of turkey. | abstract during june and july 2007, about 3125 adult ticks were collected from humans, animals, and vegetation in a hyperendemic region (sivas and tokat) of turkey. a total of 2193 ticks were pooled in 225 pools and screened for the crimean congo hemorrhagic fever virus (cchfv) presence by antigen-capture enzyme-linked immunosorbent assay. infection rates were calculated as the maximum likelihood estimation with 95% confidence intervals (ci). the dominant tick species was found to be hyalomma ma ... | 2011 | 21736490 |
| crimean congo hemorrhagic fever: requires vigilance and not panic. | crimean congo hemorrhagic fever (cchf) has been in the news with reports of its outbreak in india from gujarat. cchf is caused by a virus which is a member of the nairovirus genus of the family bunyaviridae. all of these viruses are transmitted by either ixodid or argasid ticks. humans get this infection after a bite of an infected tick or from one infected human to another by contact with infectious blood or body fluids. workers in livestock and agriculture industry, slaughterhouses, and veteri ... | 2011 | 21751625 |
| crimean-congo hemorrhagic fever: a molecular survey on hard ticks (ixodidae) in yazd province, iran. | to determine the rate of crimean-congo hemorrhagic fever virus (cchfv) infection in hard ticks (ixodidae) in yazd province of iran. | 2011 | 21771418 |
| crimean-congo haemorrhagic fever in india. | 2011 | 21784269 | |
| crimean-congo hemorrhagic fever virus in hyalommid ticks, northeastern kenya. | as part of ongoing arbovirus surveillance, we screened ticks obtained from livestock in northeastern kenya in 2008 to assess the risk for human exposure to tick-borne viruses. of 1,144 pools of 8,600 hyalomma spp. ticks screened for congo-crimean hemorrhagic fever virus by reverse transcription pcr, 23 pools were infected, demonstrating a potential for human exposure. | 2011 | 21801635 |
| cardiac findings in children with crimean-congo hemorrhagic fever. | background: crimean-congo hemorrhagic fever (cchf) involves the multi-organ systems. the involvement of the heart in adult patients has been described previously. we investigated the electrocardiographic and echocardiographic findings of pediatric patients with cchf.<br /> material/methods: patients younger than 16 years of age diagnosed with cchf were enrolled in the study. the diagnosis of cchf infection was based upon typical clinical and epidemiological findings and serological tests. all pa ... | 2011 | 21804465 |
| Epidemiology and mutational analysis of global strains of Crimean-Congo haemorrhagic fever virus. | Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high fatality. Cases are reported in several countries in Africa, Europe, the Middle East, and Asia. Phylogenetic analyses based on the virus S (nucleocapsid), M (glycoprotein), and L (polymerase) genome segments sequences indicate distinct geographic lineages exist but their specific genetic characteristics require elucidation. In this work we collected all full length S segment sequences and generated a phylogenetic tree based on ... | 2011 | 21847754 |
| Recent advances in the molecular and cellular biology of bunyaviruses. | The family Bunyaviridae of segmented, negative-stranded RNA viruses includes over 350 members that infect a bewildering variety of animals and plants. Many of these bunyaviruses are the causative agents of serious disease in their respective hosts, and are classified as emerging viruses because of their increased incidence in new populations and geographical locations throughout the world. Emerging bunyaviruses, such as Crimean-Congo hemorrhagic fever virus, tomato spotted wilt virus and Rift Va ... | 2011 | 21865443 |
| crimean-congo hemorrhagic fever serosurvey in at-risk professionals, madagascar, 2008 and 2009. | crimean-congo hemorrhagic fever (cchf) is a zoonotic arboviral infection with hemorrhagic manifestation and often a fatal ending. human become infected mainly through tick bite or by crushing infected tick, by contact with blood or tissues from viraemic livestock or patient. cchf virus (cchfv) has been isolated once in madagascar but data on the epidemiology of the disease in the country are very scarce. | 2011 | 21889395 |
| [use of rt-pcr and enzyme immunoassays for the specific diagnosis of crimean hemorrhagic fever]. | the objective of the investigation was to evaluate the efficiency of the rt-pcr kit "amplysens chf" produced by interlabservice of the central research institute of epidemiology and that of the elisa kits made by the d. i. ivanovsky research institute of virology for the specific diagnosis of crimean hemorrhagic fever (chf). examination of sera from chf patients from the astrakhan region showed that positive rt-pcr results were observed in 95.2 and 37.5% on days 4-8 and 9-13 after disease onset, ... | 2011 | 21899068 |
| Species distribution and detection of Crimean Congo Hemorrhagic Fever Virus (CCHFV) in field-collected ticks in Ankara Province, Central Anatolia, Turkey. | Ticks may act as vectors for a number of infectious diseases including Crimean Congo Hemorrhagic Fever (CCHF). The causative agent is Crimean Congo Hemorrhagic Fever Virus (CCHFV), a member of Bunyaviridae, causing extensive ecchymosis, visceral bleeding and hepatic dysfunction with a high fatality rate in the affected individuals. CCHF was initially recognized in Turkey in 2002 and the current number of reported cases exceeds 4,400. This study was conducted to confirm the presence of tick speci ... | 2012 | 21910017 |
| prompt administration of crimean-congo hemorrhagic fever (cchf) virus hyperimmunoglobulin in patients diagnosed with cchf and viral load monitorization by reverse transcriptase-pcr. | crimean-congo hemorrhagic fever virus (cchfv), a member of the genus nairovirus of the family bunyaviridae, causes a severe disease in humans with high mortality rates. in turkey, the number of patients with cchf has increased since 2002. here, we aimed to treat cchf patients with cchfv hyperimmunoglobulin. we prepared a cchfv hyperimmunoglobulin product from 22 individuals who survived cchf infection. a total of 26 cchf patients were enrolled into this study. for cchfv hyperimmunoglobulin admin ... | 2011 | 21937830 |
| tick cell lines for study of crimean-congo hemorrhagic fever virus and other arboviruses. | abstract continuous cell lines derived from many of the vectors of tick-borne arboviruses of medical and veterinary importance are now available. their role as tools in arbovirus research to date is reviewed and their potential application in studies of tick cell responses to virus infection is explored, by comparison with recent progress in understanding mosquito immunity to arbovirus infection. a preliminary study of propagation of the human pathogen crimean-congo hemorrhagic fever virus (cc ... | 2011 | 21955214 |
| using next generation sequencing to identify yellow fever virus in uganda. | in october and november 2010, hospitals in northern uganda reported patients with suspected hemorrhagic fevers. initial tests for ebola viruses, marburg virus, rift valley fever virus, and crimean congo hemorrhagic fever virus were negative. unbiased pcr amplification of total rna extracted directly from patient sera and next generation sequencing resulted in detection of yellow fever virus and generation of 98% of the virus genome sequence. this finding demonstrated the utility of next generati ... | 2012 | 21962764 |
| production of cchf virus-like particle by a baculovirus-insect cell expression system. | crimean-congo haemorrhagic fever virus (cchfv) is a tick-born virus of the nairovirus genus within the bunyaviridae family, which is widespread and causes high fatality. the nucleocapsid of cchfv is comprised of n proteins that are encoded by the s segment. in this research, the n protein of cchfv was expressed in insect cells using a recombinant baculovirus. under an electron microscope, virus-like particles (vlps) with various size and morphology were observed in cytoplasmic vesicles in the in ... | 2011 | 21979573 |
| impact of ebola mucin-like domain on antiglycoprotein antibody responses induced by ebola virus-like particles. | ebola virus (ebov) glycoprotein (gp), responsible for mediating host-cell attachment and membrane fusion, contains a heavily glycosylated mucin-like domain hypothesized to shield gp from neutralizing antibodies. to test whether the mucin-like domain inhibits the production and function of anti-gp antibodies, we vaccinated mice with ebola virus-like particles (vlps) that express vesicular stomatitis virus g, wild-type ebov gp (ebgp), ebov gp without its mucin-like domain (δmucgp), or ebov gp with ... | 2011 | 21987758 |
| Bacterial expression of Crimean-Congo hemorrhagic fever virus nucleoprotein and its evaluation as a diagnostic reagent in an indirect ELISA. | Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne viral zoonosis distributed widely in Africa, Asia, Russia and the Balkans. The emergence and re-emergence of CCHFV emphasize the importance of increasing both human and veterinary surveillance and developing diagnostic capacity. Recombinant CCHFV nucleocapsid protein (NP) has been expressed using insect cells and mammalian cells and used as a diagnostic tool but bacterial expression has not been described previously. The S gene of CCH ... | 2012 | 22001274 |
| mice orally immunized with a transgenic plant expressing the glycoprotein of crimean-congo hemorrhagic fever virus. | while crimean-congo hemorrhagic fever (cchf) has a high mortality rate in humans, the associated virus (cchfv) does not induce clinical symptoms in animals, but animals play an important role in disease transmission to humans. our aim in this study was to examine the immunogenicity of the cchfv glycoprotein when expressed in the root and leaf of transgenic plants via hairy roots and stable transformation of tobacco plants, respectively. after confirmatory analyses of transgenic plant lines and q ... | 2011 | 22012978 |
| re-emergence of crimean-congo hemorrhagic fever virus in central africa. | crimean-congo hemorrhagic fever (cchf) is a severe tick-borne disease well recognized through europe and asia where diagnostic tests and medical surveillance are available. however, it is largely neglected in africa, especially in the tropical rainforest of central africa where only sporadic human cases have been reported and date back to more than 30 years. we describe here an isolated human case that occurred in the democratic republic of the congo in 2008 and performed phylogenetic analysis t ... | 2011 | 22022629 |
| relationship between nf-κb1 and nf-κbia genetic polymorphisms and crimean-congo hemorrhagic fever. | background: crimean-congo hemorrhagic fever (cchf) is an acute viral hemorrhagic fever caused by the crimean-congo hemorrhagic fever virus (cchfv). nuclear factor (nf)-κb regulates the expression of hundreds of genes, including inflammatory and immunoregulatory, cell cycle regulating, and anti-apoptotic genes. nf-κbia (iκbα) encodes an inhibitory version of the nf-κb proteins. methods: this study is the first to investigate the association between nf-κb1 - 94w/d and nf-κbia 3→utr a→g polymorphis ... | 2011 | 22066734 |
| parotitis associated with crimean congo hemorrhagic fever virus. | crimean congo hemorrhagic fever (cchf) is a potentially fatal tick-borne viral disease, the course of which may accompanied by various clinical findings. | 2011 | 22079303 |
| Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human pathogenic Crimean-Congo Haemorrhagic Fever virus. | Hazara virus (HAZV) is closely related to Crimean-Congo Haemorrhagic Fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose response effects were seen, with higher doses resulting in a shorter time to ... | 2011 | 22090213 |
| Impact of climate change on risk of incursion of Crimean-Congo haemorrhagic fever virus in livestock in Europe through migratory birds. | Aims: To predict the risk of incursion of Crimean-Congo haemorrhagic fever virus (CCHFV) in livestock in Europe introduced through immature Hyalomma marginatum ticks on migratory birds under current conditions and in the decade 2075-2084 under a climate-change scenario. Methods and Results: A spatial risk map of Europe comprising 14 282 grid cells (25 × 25 km) was constructed using three data sources: (i) ranges and abundances of four species of bird which migrate from sub-Saharan Africa to Eu ... | 2011 | 22118269 |
| Crimean-Congo hemorrhagic fever virus in various ixodid tick species from a highly endemic area. | Ticks are major vectors of numerous diseases affecting animals and humans. Presence of various tick-borne pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) in various tick species was documented. CCHF is a severe tick-borne illness caused by the CCHFV which is a member of the Nairovirus genus (family: Bunyaviridae). Presence of CCHFV was shown in the most prevalent ixodid tick species such as Hyalomma marginatum and Rhiphicephalus bursa in Turkey. In the present study, prevalence a ... | 2011 | 22119389 |
| inhibition of interferon induction and action by the nairovirus nairobi sheep disease virus/ganjam virus. | the nairoviruses are an important group of tick-borne viruses that includes pathogens of man (crimean congo hemorrhagic fever virus) and livestock animals (dugbe virus, nairobi sheep disease virus (nsdv)). nsdv is found in large parts of east africa and the indian subcontinent (where it is known as ganjam virus). we have investigated the ability of nsdv to antagonise the induction and actions of interferon. both pathogenic and apathogenic isolates could actively inhibit the induction of type 1 i ... | 2011 | 22163042 |
| seroepidemiological study of crimean-congo haemorrhagic fever in greece, 2009-2010. | clin microbiol infect abstract: to estimate endemic areas for crimean-congo haemorrhagic fever (cchf) in greece, a country-wide seroepidemiological study was conducted, and 1611 human sera were prospectively collected along with data regarding possible risk factors for acquisition of infection, and tested for cchf virus igg antibodies by elisa. the overall seroprevalence was 4.2%, with significant differences among prefectures, ranging from 0 to 27.5%. multivariate analysis revealed that slaught ... | 2011 | 22192082 |
| serological evaluation of crimean-congo hemorrhagic fever in humans with high-risk professions living in enzootic regions of isfahan province of iran and genetic analysis of circulating strains. | crimean-congo hemorrhagic fever (cchf) is a zoonotic viral disease that is asymptomatic in infected livestock, but causes a serious threat to humans with a mortality rate up to 50%. although the cchf virus (cchfv) is often transmitted by ticks, livestock-to-human and human-to-human transmission also occurs. in the current study, we focused on cchf in the province of isfahan, located in the center of iran and deemed to be the second most infected province. human and livestock sera and resident ti ... | 2012 | 22217167 |
| possible drivers of crimean-congo hemorrhagic fever virus transmission in kosova. | abstract crimean-congo hemorrhagic fever (cchf) has long been a disease of concern in kosova; however, little is known about the enzootic cycles of the virus in this country. since the first documented case in 1954, sporadic cases and occasional outbreaks have been recorded with cases more consistently reported following the conflict in 1999. cchf virus exists in enzootic cycles between wild animal species and ticks. the infection rates within ticks and hence the exposure to humans is determin ... | 2012 | 22217174 |
| development of a real-time rt-pcr assay for the detection of crimean-congo hemorrhagic fever virus. | abstract crimean-congo hemorrhagic fever (cchf) is a virulent tick-borne disease with a case fatality rate ranging from 10-50% for tick-borne transmission, and up to 80% for nosocomial transmission. human cases have been reported in over 30 countries across europe, asia, and africa. it appears to be spreading to new areas with several countries reporting their first human cases of cchf disease within the past 10 years. we report a novel real-time rt-pcr assay designed to amplify a conserved re ... | 2012 | 22217175 |
| crimean-congo hemorrhagic fever virus-infected hepatocytes induce er-stress and apoptosis crosstalk. | crimean-congo hemorrhagic fever virus (cchfv) is a widely distributed tick-borne member of the nairovirus genus (bunyaviridae) with a high mortality rate in humans. cchfv induces a severe disease in infected patients that includes, among other symptoms, massive liver necrosis and failure. the interaction between liver cells and cchfv is therefore important for understanding the pathogenesis of this disease. here, we described the in vitro cchfv-infection and -replication in the hepatocyte cell l ... | 2012 | 22238639 |
| lack of genetic diversity in crimean-congo hemorrhagic fever viruses in turkey: assessment of present and future patterns of disease. | crimean-congo hemorrhagic fever (cchf) is a tick-borne zoonosis which is common in africa, asia, eastern europe, and the balkan peninsula. cchf has been reported in turkey with high frequency since 2002. the aim of the present study was to investigate the genetic diversity and genetic relationship between cchf virus (cchfv) isolates derived from infected patients over a 2-year period (2009 and 2010) in several provinces of turkey. serum samples (n = 48) were selected from cchfv rna positive pati ... | 2012 | 22246834 |
| crimean-congo hemorrhagic fever virus in ticks from imported livestock, egypt. | to the editor: crimean congo hemorrhagic fever, a tick-borne illness caused by crimean congo hemorrhagic fever virus (cchfv), is endemic to africa, the balkans, the middle east, and parts of asia. the hard ticks (ixodidae), especially those of the genus hyalomma, serve as reservoirs and vectors for cchfv, and a variety of animals, such as cattle, sheep, and camels, are considered amplifying hosts for the virus. although cchfv may cause little or no disease in zoonotic hosts, the virus can cause ... | 2012 | 22260737 |
| crimean-congo hemorrhagic fever virus in ticks, southwestern europe, 2010. | 0 | 22261502 | |
| importation of hyalomma marginatum, vector of crimean-congo haemorrhagic fever virus, into the united kingdom by migratory birds. | hyalomma marginatum ticks are an important vector of crimean-congo haemorrhagic fever virus which can result in a severe and potentially fatal disease in humans. given the continued emergence of clinical cases in eurasia and focalised upsurges of h. marginatum populations in europe, it seemed prudent to assess the potential of this vector species to be introduced into the united kingdom. immature forms of h. marginatum are frequent ectoparasites of passerine birds many of which migrate from afri ... | 2012 | 22300969 |
| epitope-based immunoinformatics and molecular docking studies of nucleocapsid protein and ovarian tumor domain of crimean-congo hemorrhagic fever virus. | crimean-congo hemorrhagic fever virus (cchfv), the fatal human pathogen is transmitted to humans by tick bite, or exposure to infected blood or tissues of infected livestock. the cchfv genome consists of three rna segments namely, s, m, and l. the unusual large viral l protein has an ovarian tumor (otu) protease domain located in the n terminus. it is likely that the protein may be autoproteolytically cleaved to generate the active virus l polymerase with additional functions. identification of ... | 2011 | 22303367 |
| crimean-congo hemorrhagic fever virus-tick survey in endemic areas in bulgaria. | the balkan peninsula and bulgaria in particular, is a well-known endemic region for crimean-congo hemorrhagic fever (cchf). this study describes the prevalence of crimean-congo hemorrhagic fever virus (cchfv) among tick populations from areas, previously recognized with emerging cases of cchf disease in humans. these include regions from the southeastern (regions of kardzhali and haskovo) and central (region of stara zagora) parts of the country. for the period 2006-2010 a total of 911 adult tic ... | 2012 | 22337300 |
| in situ rolling circle amplification detection of crimean congo hemorrhagic fever virus (cchfv) complementary and viral rna. | crimean congo hemorrhagic fever virus (cchfv) is a human pathogen that causes a severe disease with high fatality rate for which there is currently no specific treatment. knowledge regarding its replication cycle is also highly limited. in this study we developed an in situ technique for studying the different stages during the replication of cchfv. by integrating reverse transcription, padlock probes, and rolling circle amplification, we were able to detect and differentiate between viral rna ( ... | 2012 | 22341783 |
| crimean-congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. | crimean-congo hemorrhagic fever virus (cchfv), a virus with high mortality in humans, is a member of the genus nairovirus in the family bunyaviridae, and is a causative agent of severe hemorrhagic fever (hf). it is classified as a biosafety level 4 pathogen and a potential bioterrorism agent due to its aerosol infectivity and its ability to cause hf outbreaks with high case fatality (∼30%). however, little is known about the structural features and function of nucleoproteins (nps) in the bunyavi ... | 2012 | 22421137 |
| unraveling the ecological complexities of tick-associated crimean-congo hemorrhagic fever virus transmission: a gap analysis for the western palearctic. | this review aims to summarize the current knowledge of the eco-epidemiology of crimean-congo hemorrhagic fever (cchf) virus transmission reviewing the most recent scientific advances in the last few decades of epidemic and non-epidemic ("silent") periods. we explicitly aim to highlight the dynamics of transmission that are still largely unknown. recent knowledge gathered from research in africa and europe explains the very focal nature of the virus, and indicates that research on the ecology of ... | 2012 | 22448676 |
| an assessment of the distribution and spread of the tick hyalomma marginatum in the western palearctic under different climate scenarios. | we applied a process-driven model to evaluate the impact of climate scenarios for the years 2020, 2050, and 2080 on the life cycle of hyalomma marginatum ticks in the western palearctic. the net growth rate of the tick populations increased in every scenario tested compared to the current climate baseline. these results support the expectations of increased tick survival and increased population turnover in future climate scenarios. we included a basic evaluation of host movement based on rules ... | 2012 | 22448680 |
| serosurvey and molecular detection of crimean-congo hemorrhagic fever virus (cchfv) in northern turkey. | in this study, the hard ticks, whole blood and serum samples collected from small ruminants (sheep and goat) in middle black sea region of turkey where crimean-congo hemorrhagic fever (cchf) human cases were observed in the past years were surveyed for the presence of rna and specific igg antibodies from ccfh virus (cchfv). cchfv rna was found in 30 of 255 tick pools (11.76%) and nine of 105 (8.57%) leucocyte samples. no cchfv genomic rna was detected from animals in yildizeli and vezirkopru. ho ... | 2012 | 22457191 |
| subclinical infections with crimean-congo hemorrhagic fever virus, turkey. | to investigate crimean-congo hemorrhagic fever virus in turkey, we conducted a seroepidemiologic survey during january-april 2009. seroprevalence of infection was 10% in a sample from an outbreak region and increased with patient age, indicating that the virus had been previously present in turkey. we also estimated that 88% of infections were subclinical. | 2012 | 22469474 |
| impact of climate trends on tick-borne pathogen transmission. | recent advances in climate research together with a better understanding of tick-pathogen interactions, the distribution of ticks and the diagnosis of tick-borne pathogens raise questions about the impact of environmental factors on tick abundance and spread and the prevalence and transmission of tick-borne pathogens. while undoubtedly climate plays a role in the changes in distribution and seasonal abundance of ticks, it is always difficult to disentangle factors impacting on the abundance of t ... | 2012 | 22470348 |
| crimean-congo hemorrhagic fever virus: new outbreaks, new discoveries. | crimean-congo hemorrhagic fever (cchf) is a fatal viral infection described in asia, africa and europe. humans become infected through the bites of ticks, by contact with a patient with cchf during the acute phase of infection, or by contact with blood or tissues from viremic livestock. the occurrence of cchf closely approximates the known world distribution of hyalomma spp. ticks. the novel studies of phylogenetic analyses reveal the interesting relations between the strains from distant outbre ... | 2012 | 22482717 |
| tick-borne viruses in europe. | the aim of this review is to present briefly background information on 27 tick-borne viruses ("tiboviruses") that have been detected in europe, viz flaviviruses tick-borne encephalitis (tbev), louping-ill (liv), tyuleniy (tyuv), and meaban (meav); orthobunyaviruses bahig (bahv) and matruh (mtrv); phleboviruses grand arbaud (gav), ponteves (ptvv), uukuniemi (uukv), zaliv terpeniya (ztv), and st. abb's head (sahv); nairoviruses soldado (solv), puffin island (piv), avalon (avav), clo mor (cmv), cri ... | 2012 | 22526290 |
| detection, isolation and confirmation of crimean-congo hemorrhagic fever virus in human, ticks and animals in ahmadabad, india, 2010-2011. | in january 2011, human cases with hemorrhagic manifestations in the hospital staff were reported from a tertiary care hospital in ahmadabad, india. this paper reports a detailed epidemiological investigation of nosocomial outbreak from the affected area of ahmadabad, gujarat, india. | 2012 | 22616022 |
| reverse transcription pcr-based detection of crimean-congo hemorrhagic fever virus isolated from ticks of domestic ruminants in kurdistan province of iran. | crimean-congo hemorrhagic fever (cchf) is a potentially fatal viral vector-borne zoonosis which has a mortality rate of up to 30% without treatment in humans. cchf virus is transmitted to humans by ticks, predominantly from the hyalomma genus. following the report of two confirmed and one suspected death due to cchf virus in kurdistan province of iran in 2007, this study was undertaken to determine the fauna of hard ticks on domestic ruminants (cattle, sheep, and goats) and their possible infect ... | 2012 | 22651389 |
| expression, purification and crystallization of the crimean-congo haemorrhagic fever virus nucleocapsid protein. | crimean-congo haemorrhagic fever virus (cchfv) is a member of the nairovirus genus within the bunyaviridae family of segmented negative-sense rna viruses. this paper describes the expression, purification and crystallization of full-length cchfv nucleocapsid (n) protein and the collection of a 2.1 å resolution x-ray diffraction data set using synchrotron radiation. crystals of the cchfv n protein belonged to space group c2, with unit-cell parameters a = 150.38, b = 72.06, c = 101.23 å, β = 110.7 ... | 2012 | 22691790 |
| detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines. | as well as being vectors of many viral, bacterial, and protozoan pathogens of medical and veterinary importance, ticks harbour a variety of microorganisms which are not known to be pathogenic for vertebrate hosts. continuous cell lines established from ixodid and argasid ticks could be infected with such endosymbiotic bacteria and endogenous viruses, but to date very few cell lines have been examined for their presence. dna and rna extracted from over 50 tick cell lines deposited in the roslin w ... | 2012 | 22743047 |
| first international external quality assessment of molecular detection of crimean-congo hemorrhagic fever virus. | crimean-congo hemorrhagic fever (cchf) is a zoonosis caused by a nairovirus of the family bunyaviridae. infection is transmitted to humans mostly by hyalomma ticks and also by direct contact with the blood or tissues of infected humans or viremic livestock. clinical features usually include a rapid progression characterized by hemorrhage, myalgia and fever, with a lethality rate up to 30%. cchf is one of the most widely distributed viral hemorrhagic fevers and has been reported in africa, the mi ... | 2012 | 22745842 |
| genetic characterization of erve virus, a european nairovirus distantly related to crimean-congo hemorrhagic fever virus. | erve virus (ervev) is a european nairovirus that is suspected to cause severe headache (thunderclap headache) and intracerebral hemorrhage. the mode of transmission to humans (ticks or mosquitoes) is still unknown. currently, no standardized testing method for ervev exists and only a small partial sequence of the polymerase gene is available. here, we present the first complete genome sequence of ervev s, m, and l segments. phylogenetic comparison of the amino acid sequence of the l-protein (rna ... | 2012 | 22864548 |
| structure, function, and evolution of the crimean-congo hemorrhagic fever virus nucleocapsid protein. | crimean-congo hemorrhagic fever virus (cchfv) is an emerging tick-borne virus of the bunyaviridae family that is responsible for a fatal human disease for which preventative or therapeutic measures do not exist. we solved the crystal structure of the cchfv strain baghdad-12 nucleocapsid protein (n), a potential therapeutic target, at a resolution of 2.1 å. n comprises a large globular domain composed of both n- and c-terminal sequences, likely involved in rna binding, and a protruding arm domain ... | 2012 | 22875964 |
| first report of adult hyalomma marginatum rufipes (vector of crimean-congo haemorrhagic fever virus) on cattle under a continental climate in hungary. | south hungary is being monitored for the northward spreading of thermophilic ixodid species, therefore ticks were collected from cattle and wild ruminants (red, fallow and roe deer) in the autumn of 2011. | 2012 | 22889105 |
| first serologic evidence for the circulation of crimean-congo hemorrhagic fever virus in romania. | serum samples from sheep in localities situated in the county of tulcea, northern dobrogea, were tested with an igg sandwich elisa using a recombinant crimean-congo hemorrhagic fever virus (cchfv) antigen. in all, 131 sera out of 471 tested (27.8%) had igg antibodies specific to cchfv. this is the first evidence for the circulation of cchfv virus in romania. | 2012 | 22897346 |
| healthy individuals' immune response to the bulgarian crimean-congo hemorrhagic fever virus vaccine. | crimean-congo hemorrhagic fever virus (cchfv) poses a great threat to public health due to its high mortality and transmission rate and wide geographical distribution. there is currently no specific antiviral therapy for cchf. this study provides the first in-depth analysis of the cellular and humoral immune response in healthy individuals following injection of inactivated bulgarian vaccine, the only cchfv vaccine available at present. vaccinated individuals developed robust, anti-cchfv-specifi ... | 2012 | 22902680 |
| [detection of crimean-congo hemorrhagic fever virus rna in the hyalomma marginatum ticks taken from bitten people]. | among 1076 imagoes of the hyalomma marginatum ticks taken from bitten people in the astrakhan region in 2006-2010, 10 (0.9%) ticks contained crimean-congo hemorrhagic fever (cchf) virus rna, as evidenced by rt-pcr. the diagnosis of cchf was made on the basis of clinical data and the results of examination of sera in rt-pcr, elisa-igm, and elisa-iga in three of the 10 persons bitten by infected ticks. two more patients were observed to have acute febrile diseases, but their sera were not examined ... | 2016 | 22905426 |
| application of the pseudo-plaque assay for detection and titration of crimean-congo hemorrhagic fever virus. | a pseudo-plaque assay was developed for detection and quantitation of crimean-congo hemorrhagic fever virus turkey-kelkit06. enzyme-catalyzed color development of infected cells probed with anti-crimean-congo hemorrhagic fever virus antibodies was used for determining the titer of crimean-congo hemorrhagic fever turkey-kelkit06 and for its detection in samples from persons infected with the crimean-congo hemorrhagic fever virus. the pseudo-plaque assay accuracy was confirmed by comparing pseudo- ... | 2013 | 22906394 |
| seroprevalence of crimean congo hemorrhagic fever virus in ijara district, kenya. | crimean-congo hemorrhagic fever (cchf) is a tick-borne viral disease mainly affecting pastoralists who come in contact with animals infested with hyalomma ticks, which are the key vectors of cchf virus (cchfv). cchfv has been detected among these ticks in parts of north eastern kenya. this study aimed to identify acute cases of cchf, and to determine the extent of previous exposure to cchfv in an outpatient population attending sangailu and ijara health centers, ijara district, north eastern ken ... | 2012 | 22925021 |
| relationship between crimean-congo hemorrhagic fever virus strains circulating in iran and turkey: possibilities for transborder transmission. | crimean-congo hemorrhagic fever (cchf) is an important zoonotic viral disease that is asymptomatic in infected livestock, but poses a serious threat to humans. the high fatality rate may be due to phylogenetic variations in the virus, transmission routes, and a lack of an efficient surveillance system for the disease. the geographical features of the eastern and southeastern borders of turkey may facilitate transmission of viruses between countries of the region. therefore in this study we focus ... | 2012 | 22925023 |
| the emergence and maintenance of vector-borne diseases in the khyber pakhtunkhwa province, and the federally administered tribal areas of pakistan. | human populations throughout much of the world are experiencing unprecedented changes in their relationship to the environment and their interactions with the animals with which so many humans are intimately dependent upon. these changes result not only from human induced changes in the climate, but also from population demographic changes due to wars, social unrest, behavioral changes resulting from cultural mixing, and large changes in land-use practices. each of these social shifts can affect ... | 2012 | 22934007 |
| structure of crimean-congo hemorrhagic fever virus nucleoprotein: superhelical homo-oligomers and the role of caspase-3 cleavage. | crimean-congo hemorrhagic fever, a severe hemorrhagic disease found throughout africa, europe, and asia, is caused by the tick-borne crimean-congo hemorrhagic fever virus (cchfv). cchfv is a negative-sense single-stranded rna (ssrna) virus belonging to the nairovirus genus of the bunyaviridae family. its genome of three single-stranded rna segments is encapsidated by the nucleocapsid protein (cchfv n) to form the ribonucleoprotein complex. this ribonucleoprotein complex is required during replic ... | 2012 | 22951837 |
| factors driving the circulation and possible expansion of crimean-congo haemorrhagic fever virus in the western palearctic. | to produce a spatial risk map regarding spread of crimean-congo haemorrhagic fever virus (cchfv) in the western palearctic by linking a process-driven model of the main tick vector, hyalomma marginatum, to a next generation matrix. | 2013 | 23061817 |
| ganjam virus/nairobi sheep disease virus induces a pro-inflammatory response in infected sheep. | partly due to climate change, and partly due to changes of human habitat occupation, the impact of tick-borne viruses is increasing. nairobi sheep disease virus (nsdv) and ganjam virus (gv) are two names for the same virus, which causes disease in sheep and goats and is currently known to be circulating in india and east africa. the virus is transmitted by ixodid ticks and causes a severe hemorrhagic disease. we have developed a real-time pcr assay for the virus genome and validated it in a pilo ... | 2012 | 23083136 |
| migratory birds, ticks, and crimean-congo hemorrhagic fever virus. | 0 | 23171591 | |
| genetic characterization and molecular clock analyses of the crimean-congo hemorrhagic fever virus from human and ticks in india, 2010-2011. | a nosocomial outbreak of crimean congo hemorrhagic fever (cchf) was reported among humans in ahmadabad district, gujarat, india during january, 2011. in the present study we provide the complete genomic sequences of four cchfv isolates derived from two human patients and two pools of hyalomma anatolicum ticks during the period of this outbreak and the complete s segment sequence of two retrospective human serum samples, positive for cchfv in 2010. sequence-based molecular characterization of the ... | 2013 | 23195573 |
| tick survey and detection of crimean-congo hemorrhagic fever virus in tick species from a non-endemic area, south marmara region, turkey. | crimean-congo hemorrhagic fever (cchf) is an increasing health concern in turkey since 2002. there were also some recent human cases from the south marmara region of turkey; thus, a tick survey was performed, and possible vector tick species for the cchf virus were determined in the region. a total of 740 adult ticks were collected from infested livestock from five locations: çanakkale-biga, bursa-orhaneli, bursa-keles, balıkesir and bilecik. total of 11 tick species from the genera hyalomma, rh ... | 2013 | 23229492 |
| molecular diagnostic and genetic characterization of highly pathogenic viruses: application during crimean-congo haemorrhagic fever virus outbreaks in eastern europe and the middle east. | several haemorrhagic fevers are caused by highly pathogenic viruses that must be handled in biosafety level 4 (bsl-4) containment. these zoonotic infections have an important impact on public health and the development of a rapid and differential diagnosis in case of outbreak in risk areas represents a critical priority. we have demonstrated the potential of a dna resequencing microarray (pathogenid v2.0) for this purpose. the microarray was first validated in vitro using supernatants of cells i ... | 2012 | 23240764 |
| molecular evolution of crimean-congo hemorrhagic fever virus based on complete genomes. | crimean-congo hemorrhagic fever virus (cchfv), which is widely distributed in parts of asia, africa and europe, often causes fatal viral infections in humans. however, its evolutionary features are still unclear. in this study, a total of 22 global cchfv strains with complete genome segments were analysed. three medium (m) segment reassortants and two small (s) segment reassortants were newly identified. according to bayesian analysis of the s, m and large (l) segment datasets with and without r ... | 2013 | 23255625 |
| seroprevalence of crimean-congo hemorrhagic fever virus, bulgaria. | 0 | 23260369 | |
| new circulating genomic variant of crimean-congo hemorrhagic fever virus in iran. | crimean-congo hemorrhagic fever is a viral infection that is caused by crimean-congo hemorrhagic fever virus (cchfv). on may 27, 2012, a woman became ill after accidentally splashing cow's blood into her eyes. serological and molecular investigations were carried out on the serum of the patient. the test results for serological testing were negative, but rt-pcr was strongly positive for cchfv. a phylogenetic study on the cchfv genome sequence showed 50 % similarity to a 520-bp region of russian ... | 2012 | 23271164 |
| pseudo-plaque reduction neutralization test (pprnt) for the measurement of neutralizing antibodies to crimean-congo hemorrhagic fever virus. | crimean-congo hemorrhagic fever virus (cchfv) is a tick-borne virus of the genus nairovirus family bunyaviridae, which are enveloped viruses containing tripartite, negative polarity, single-stranded rna. cchf is characterized by high case mortality, occurring in asia, africa, the middle east and europe. currently, there are no specific treatments or licensed vaccines available for cchfv. recently, two research groups have found adult mice with defective interferon responses allowed to lethal cch ... | 2013 | 23282186 |