| a case report of crescentic glomerulonephritis associated with hantaan virus infection. | although various glomerular diseases in hantavirus infection have been reported, an association between hantavirus infection and crescentic glomerulonephritis has not been described. herein, we report a case of immune complex-mediated crescentic glomerulonephritis in a 70-year-old man with hantaan virus infection. | 2010 | 20466689 |
| the triplet repeats of the sin nombre hantavirus 5' untranslated region are sufficient in cis for nucleocapsid-mediated translation initiation. | hantavirus nucleocapsid protein (n) can replace the cellular cap-binding complex, eukaryotic initiation factor 4f (eif4f), to mediate translation initiation. although n can augment translation initiation of nonviral mrna, initiation of viral mrna by n is superior. all members of the bunyaviridae family, including the species of the hantavirus genus, express either three or four primary mrnas from their tripartite negative-sense genomes. the 5' ends of the mrnas contain nonviral heterologous olig ... | 2010 | 20573811 |
| alpha/beta interferon (ifn-alpha/beta)-independent induction of ifn-lambda1 (interleukin-29) in response to hantaan virus infection. | type iii interferons ([ifns] ifn-lambda and interleukin-28 and -29 [il-28/29]) are recently recognized cytokines with innate antiviral effects similar to those of type i ifns (ifn-alpha/beta). like ifn-alpha/beta, ifn-lambda-expression can be induced by viruses, and it is believed that type i and iii ifns are regulated in the same manner. hantaviruses are weak ifn-alpha/beta inducers and have surprisingly been shown to activate ifn-alpha/beta-independent ifn-stimulated gene (isg) expression. her ... | 2010 | 20592090 |
| confirmation of choclo virus as the cause of hantavirus cardiopulmonary syndrome and high serum antibody prevalence in panama. | choclo virus (chov) was described in sigmodontine rodents, oligoryzomys fulvescens, and humans during an outbreak of hantavirus cardiopulmonary syndrome (hcps) in 1999-2000 in western panama. although hcps is rare, hantavirus-specific serum antibody prevalence among the general population is high suggesting that chov may cause many mild or asymptomatic infections. the goals of this study were to confirm the role of chov in hcps and in the frequently detected serum antibody and to establish the p ... | 2010 | 20648614 |
| [study on the transmission of hantaan virus and orientia tsutsugamushi by naturally dual infected leptotrombidium scutellare through stinging]. | to investigate whether leptotrombidium scutellare could be naturally infected by both hantaan virus (hv) and orientia tsutsugamushi (ot) and transmission status by stinging. | 2010 | 20654145 |
| switch to high-level virus replication and hla class i upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. | hantaan virus (htnv), the prototype member of the hantavirus genus in the family bunyaviridae, causes hemorrhagic fever with renal syndrome (hfrs) in humans. hemorrhage is due to endothelial barrier damage and a sharp decrease in platelet counts. the mechanisms underlying htnv-associated acute thrombocytopenia have not been elucidated so far. platelets are produced by mature megakaryocytes that develop during megakaryopoiesis. in this study, we show that htnv targets megakaryocytic cells whereas ... | 2010 | 20673746 |
| reversible splenium lesion of the corpus callosum in hemorrhagic fever with renal failure syndrome. | this is the first case of virus-associated encephalitis/encephalopathy in which the pathogen was hantaan virus. a 53-yr-old man presented fever, renal failure and a hemorrhagic tendency and he was diagnosed with hemorrhagic fever with renal failure syndrome (hfrs). in the course of his illness, mild neurologic symptoms such as dizziness and confusion developed and magnetic resonance images revealed a reversible lesion in the splenium of the corpus callosum. this case suggests that hfrs patients ... | 2010 | 20676343 |
| hantavirus infections in humans and animals, china. | hemorrhagic fever with renal syndrome (hfrs) is a serious public health problem in the people's republic of china. although 7 sero/genotypes of hantaviruses have been found in rodents, only hantaan virus (carried by apodemus agrarius mice) and seoul virus (carried by rattus norvegicus rats) reportedly cause disease in humans. during 1950-2007, a total of 1,557,622 cases of hfrs in humans and 46,427 deaths (3%) were reported in china. hfrs has been reported in 29 of 31 provinces in china. after i ... | 2010 | 20678311 |
| acute kidney injury in tropical acute febrile illness in a tertiary care centre--rifle criteria validation. | acute febrile illnesses are a common cause of tropical acute kidney injury (aki). the incidence and severity of aki in tropical febrile illnesses and validity of rifle classification are unclear. | 2011 | 20702532 |
| spatiotemporal trends and climatic factors of hemorrhagic fever with renal syndrome epidemic in shandong province, china. | hemorrhagic fever with renal syndrome (hfrs) is a rodent-borne disease caused by hantaviruses. it is endemic in all 31 provinces, autonomous regions, and metropolitan areas in mainland china where human cases account for 90% of the total global cases. shandong province is among the most serious endemic areas. hfrs cases in shandong province were first reported in yutai county in 1968. since then, the disease has spread across the province, and as of 2005, all 111 counties were reported to have l ... | 2010 | 20706629 |
| elevated sicam-1 levels in patients with hemorrhagic fever with renal syndrome caused by hantaan virus. | increased vascular permeability and vascular leakage are characteristic pathological changes in hemorrhagic fever with renal syndrome (hfrs). vascular endothelial cells are the main targets of hantaan virus, the etiological agent of the severe form of hfrs. hantaan virus can induce extensive damage of small blood vessels and capillaries. in vitro infection of human umbilical vein endothelial cells by hantaan virus can induce the expression of intercellular adhesion molecule-1 (icam-1). the invol ... | 2010 | 20725844 |
| severely modified lipoprotein properties without a change in cholesteryl ester transfer protein activity in patients with acute renal failure secondary to hantaan virus infection. | patients with hemorrhagic fever with renal syndrome (hfrs) often exhibit altered serum lipid and lipoprotein profile during the oliguric phase of the disease. serum lipid and lipoprotein profiles were assessed during the oliguric and recovery phases in six male patients with hfrs. in the oliguric phase of hfrs, the apolipoprotein (apo) c-iii content in high-density lipoproteins (hdl) was elevated, whereas the apoa-i content was lowered. the level of expression and activity of antioxidant enzymes ... | 2010 | 20797315 |
| environmental risk factors for haemorrhagic fever with renal syndrome in a french new epidemic area. | summaryin france, haemorrhagic fever with renal syndrome (hfrs) is endemic along the belgian border. however, this rodent-borne zoonosis caused by the puumala virus has recently spread south to the franche-comté region. we investigated the space-time distribution of hfrs and evaluated the influence of environmental factors that drive the hantavirus reservoir abundance and/or the disease transmission in this area. a scan test clearly indicated space-time clustering, highlighting a single-year (20 ... | 2011 | 20822577 |
| ecology of hantaan virus at twin bridges training area, gyeonggi province, republic of korea, 2005-2007. | the twin bridges training area (tbta) in the republic of korea consists of dirt roads, barren training areas, and forested hillsides adjacent to linear and broad expanses of tall grasses, herbaceous, and scrub vegetation. of the six species of small mammals, the striped field mouse, apodemus agrarius, was the most frequently captured (96.1%). apodemus agrarius capture rates varied from 17.7 to 33.2% during three trapping periods. gravid females were observed during november-december 2006 (8.4%) ... | 2009 | 20836826 |
| in vivo kinetics and biodistribution of a hantaan virus dna vaccine after intramuscular injection in mice. | to study the kinetics in vivo of a hantaan virus dna vaccine, we constructed a fusion dna vaccine, pegfp/s, by cloning the s segment of hantavirus into the vector, pegfp-c1, which encodes green fluorescent protein egfp. in this report, we provide evidence that pegfp/s was distributed and persistently expressed for more than 60 days in several organs after inoculation. our findings suggest that the persistent immune responses induced by a hantaan virus dna vaccine are likely due to the plasmid pe ... | 2010 | 20960291 |
| [construction and immunogenic study of recombinant adenovirus containing chimeric gene g2s0.7 and ctl epitopes of hantaan virus]. | to express g2 fragment of m segment and 0.7 kb fragment of s segment and several ctl epitopes of s segment in adenovirus expression system and investigate the immunological properties of hantaan virus chimeric gene. | 2010 | 21055343 |
| structural studies of hantaan virus. | hantaan virus is the prototypic member of the hantavirus genus within the family bunyaviridae and is a causative agent of the potentially fatal hemorrhagic fever with renal syndrome. the bunyaviridae are a family of negative-sense rna viruses with three-part segmented genomes. virions are enveloped and decorated with spikes derived from a pair of glycoproteins (gn and gc). here, we present cryo-electron tomography and single-particle cryo-electron microscopy studies of hantaan virus virions. we ... | 2010 | 21068243 |
| tracking hantavirus nucleocapsid protein using intracellular antibodies. | hantavirus nucleocapsid (n) protein is a multifunctional viral macromolecule involved in multiple stages of the viral replication cycle. the intracellular trafficking of n protein during virus assembly remains unclear. | 2010 | 21092325 |
| detection of crimean-congo hemorrhagic fever, hanta, and sandfly fever viruses by real-time rt-pcr. | the development of sensitive and specific nucleic acid diagnostic assays for viral pathogens is essential for proper medical intervention. this chapter describes four fluorescence-based pcr assays to detect the crimean-congo hemorrhagic fever (cchfv), andes (andv), hantaan (hanv), and sandfly fever sicilian (sfsv) viruses. these assays are based on species-specific hydrolysis probes targeting the nucleocapsid protein gene for cchfv and sfsv and the glycoprotein gene for andv and hanv. all four a ... | 2011 | 21116810 |
| acute kidney injury in patients with hemorrhagic fever with renal syndrome caused by hantaan virus: comparative evaluation by rifle and akin criteria. | abstract acute kidney injury (aki) is one of the most prominent characteristics of hemorrhagic fever with renal syndrome (hfrs) caused by hantaan virus. the present study evaluated the incidence and severity of aki classified by both the rifle and akin criteria in 120 hfrs patients at 48 h and 1 week of the patient admission. the agreements between rifle and akin and rifle and akin defined by serum creatinine (akinc and riflec) were examined by kappa statistics. aki occurred in 79.2% and 82.5% a ... | 2010 | 21142962 |
| [genetic analysis of hantaviruses carried by rattus norvegicus collected from henan and neimenggu provinces, china.] | objective: genetic analysis was performed to infer the relationship between hantaviruses carried by rattus norvegicus from henan and neimenggu provinces and the other known hantavirus and the vaccine strain. methods: total rna was extracted from lung tissues with trizol reagent. the complete m and s segment sequences of strains nm133 and q12 were amplified by rt-pcr. the purified dna fragments were directly subjected to sequencing, and then to sequence analysis and phylogenetic analysis. results ... | 2010 | 21162871 |
| an efficient in vivo method for the isolation of puumala virus in syrian hamsters and the characterization of the isolates from russia. | puumala virus (puuv) and other arvicolinae-borne hantaviruses are difficult to cultivate in cell culture. to isolate these hantaviruses efficiently, hantavirus nucleocapsid protein (np)-positive but seronegative wild rodents were selected by np-detection elisa. three of 68 myodes glareolus captured in samara, russia, were np-positive and seronegative. syrian hamsters were inoculated with lung homogenates from np-positive rodents for virus propagation. virus isolation in vitro was carried out by ... | 2010 | 21192975 |
| specific humoral reaction of hemorrhagic fever with renal syndrome (hfrs) patients in china to recombinant nucleocapsid proteins from european hantaviruses. | hemorrhagic fever with renal syndrome (hfrs) is endemic in east asia and europe. this study was initiated to investigate the reactivity of antibodies in sera of chinese hfrs patients with the recombinant nucleocapsid proteins (rnps) of hantaan virus (htnv), dobrava-belgrade virus (dobv), and puumala virus (puuv), which are the prevalent hantavirus strains in europe. forty-eight pairs of acute and convalescent sera were collected from hfrs patients in hubei, china (1985-2002) and tested by indire ... | 2011 | 21222012 |
| old world hantaviruses do not produce detectable amounts of dsrna in infected cells and the 5' termini of their genomic rnas are monophosphorylated. | dsrna and 5'-triphosphate rna are considered critical activators of the innate immune response because of their interaction with pattern recognition receptors. it has been reported that no dsrna is detected in negative-sense rna virus-infected cells and that hantaan virus (htnv) genomic rna bears a 5' monophosphate group. in this paper we examine the 5' termini of genomic rnas of and dsrna production by two major groups of old world hantaviruses. no detectable amounts of dsrna were found in infe ... | 2011 | 21289157 |
| seroepidemiological survey of hantavirus infection in healthy people in vallès occidental, barcelona. | hantaviruses are the etiological agents of hemorrhagic fever with renal syndrome in europe and asia, and hantavirus pulmonary syndrome in america. approximately 150,000 cases are reported annually worldwide. in spain, some hantavirus infection cases have been described. besides, rodents that have been described as hantavirus reservoirs are present. the aim of the present study was to determinate the seroprevalence of hantavirus in humans in the northeast of spain. | 2011 | 21417923 |
| comparison of hantaan and seoul viral infections among patients with hemorrhagic fever with renal syndrome (hfrs) in heilongjiang, china. | hemorrhagic fever with renal syndrome (hfrs) is a serious public health problem in china, and is primarily caused by either the hantaan virus (htnv) or seoul virus (seov) strains. however, the causative hantavirus has only been definitively identified in a few hfrs cases, and detailed comparisons of patient data for the 2 strains are limited. | 2011 | 21428852 |
| prevalence of hantavirus infection in wild rodents from five provinces in korea, 2007. | hemorrhagic fever with renal syndrome (hfrs) is an infectious disease caused by hantaviruses of the family bunyaviridae. among them, hantaan virus (htnv) is most widely distributed in korea. the striped field mouse, apodemus agrarius, is the natural host of htnv in rural korea. we trapped 766 small mammals of three species (1 eothenomys regulus, 13 crocidura suaveolens, and 752 apodemus agrarius) in five provinces in korea from january to december 2007. we tested 542 rodent sera for htnv antibod ... | 2011 | 21441196 |
| severe crescentic glomerulonephritis linked to an acute hantaan virus infection? | | 2011 | 21460361 |
| comparative virology and aids (review). | the scientific debate between pros and cons of the hiv criminal theory of aids still remains unsettled. the purpose of this review is to promote resolution of the problem by extracting a common principle of the host-virus relation using data resources for each of 4 viruses as follows: a) polyoma virus, b) marek's disease virus, c) ebola virus, d) korean hemorrhagic fever virus. conclusions drawn from this study are given as follows: i) environment emerged as the cardinal factor to modify the pro ... | 1996 | 21594370 |
| rna helicase retinoic acid-inducible gene i (rig-i) as a sensor of hantaan virus (htnv) replication. | hantaan virus (htnv) causes severe human disease. the htnv genome consists of three ssrna segments of negative polarity which are complexed with viral nucleocapsid (n) protein. how the human innate immune system detects htnv is unclear. rna heli-case retinoic acid-inducible gene i (rig-i) does not sense genomic htnv rna. so far it has not been analyzed whether pathogen associated molecular patterns (pamps) gen-erated during the htnv replication trigger rig-i-mediated innate responses. indeed, we ... | 2011 | 21632559 |
| ecological surveillance of small mammals at dagmar north training area, gyeonggi province, republic of korea, 2001-2005. | a seasonal rodent-borne disease surveillance program was established at dagmar north training area located near the demilitarized zone, republic of korea, from 2001 through 2005. selected habitats surveyed included earthen banks separating rice paddies, fighting positions along a 5 m rock-faced earthen berm, and extensive tall grasses with various degrees of herbaceous and scrub vegetation associated with dirt roads, rice paddies, ditches, ponds, or the imjin river. of the nine species of small ... | 2011 | 21635640 |
| improvement of the specificity of a pan-viral microarray by using genus-specific oligonucleotides and reduction of interference by host genomes. | rapid detection of viral pathogens is crucial for antiviral therapy. high-density 60-70-mer oligonucleotide microarrays have been explored for broad detection of many viruses. however, relatively low specificity and the complex analytical processes are the major limitations when pan-viral oligonucleotide microarrays are used to detect viral pathogens. in this study, genus-specific oligonucleotides were used as probes and modified sample preparations were carried out to improve the specificity an ... | 2011 | 21739454 |
| Rodent-Borne Hantaviruses in Cambodia, Lao PDR, and Thailand. | In order to evaluate the circulation of hantaviruses present in southeast Asia, a large scale survey of small mammal species was carried out at seven main sites in the region (Cambodia, Lao People's Democratic Republic, and Thailand). Small scale opportunistic trapping was also performed at an eighth site (Cambodia). Using a standard IFA test, IgG antibodies reacting to Hantaan virus antigens were detected at six sites. Antibody prevalence at each site varied from 0 to 5.6% with antibodies detec ... | 2011 | 22124701 |
| Modification of the adenoviral transfer vector enhances expression of the Hantavirus fusion protein GnS0.7 and induces a strong immune response in C57BL/6 mice. | Hantavirus glycoproteins (Gn and Gc) are significant components of vaccines for haemorrhagic fever with renal syndrome (HFRS); however, they are not effective due to weak immunogenicity and low levels of production in expression systems. To circumvent this problem, a 0.7-kb fragment of the S segment was fused to Gn, and a hybrid CAG promoter/enhancer in conjunction with (or without) the WPRE (Woodchuck hepatitis virus post-transcriptional regulatory element) was used to improve the expression of ... | 2012 | 22015676 |
| In vitro and in vivo activity of ribavirin against Andes virus infection. | Pathogenic hantaviruses are a closely related group of rodent-borne viruses which are responsible for two distinct diseases in humans, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome (HPS, otherwise known as hantavirus cardiopulmonary syndrome, HCPS). The antiviral effect of ribavirin against Old World hantaviruses, most notably Hantaan virus, is well documented; however, only a few studies have addressed its inhibitory effect on New World hantaviruses. In the present stu ... | 2011 | 21853152 |
| Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice. | Hantaan virus (HTNV) is the causative agent of the most severe form of a rodent-borne disease known as hemorrhagic fever with renal syndrome (HFRS). A safe and effective HTNV vaccine is needed. Vaccination with DNA constructs expressing fused antigen with bioactive factors, has shown promising improvement of immunogenicity for viral agents in animal models, but the effect of fusion strategy on HTNV DNA vaccine has not been investigated. | 2011 | 21943202 |
| Genetic analysis of hantaviruses and their rodent hosts in central-south China. | Hantaan virus (HTNV) and Seoul virus (SEOV) are two major zoonotic pathogens of hemorrhagic fever with renal syndrome (HFRS) in Asia. Hubei province, which is located in the central-south China, had been one of the most severe epidemic areas of HFRS. To investigate phylogenetic relationships, genetic diversity and geographic distribution of HTNV and SEOV in their reservoir hosts, a total of 687 rodents were trapped in this area between 2000 and 2009. Sequences of partial S- and M-segments of han ... | 2011 | 22108583 |
| antigenic characterization of expressed complete and different truncated recombinant nucleocapsid proteins of hantaan virus by monoclonal antibodies. | the nucleocapsid protein (np) of hantavirus has been shown to be highly immunogenic in laboratory animals and humans, and it induces an early and long-lasting humoral immune response during hantavirus infection. in the present study, entire and three partially truncated open reading frames (orf) of np genes of hantaan virus (htnv) strain 76-118, a prototype of hantavirus, were amplified and then cloned in prokaryotic expression vectors. the recombinant whole np and truncated nps were expressed i ... | 2011 | 22008071 |
| application of truncated nucleocapsid protein (n) for serotyping elisa of murinae-associated hantavirus infection in rats. | truncated recombinant nucleocapsid proteins (trns) that lack n-terminally located cross-reactive epitopes of four murinae rodent-associated hantaviruses, seoul virus (seov), thailand virus, hantaan virus (htnv) and dobrava-berglade virus, were produced by using a baculovirus expression system. elisa with the trns as antigens enabled serotyping of immune sera from rats experimentally inoculated with the corresponding hantaviruses as cut-off od values of 60% to those to whole n of htnv. the trn ba ... | 2011 | 21937858 |
| efficient production of hantaan and puumala pseudovirions for viral tropism and neutralization studies. | puumala (puuv) and hantaan (htnv) viruses are hantaviruses within the family bunyaviridae and associated with hemorrhagic fever with renal syndrome (hfrs) in humans. little is known about how these viruses interact with host cells, though pathogenic hantaviruses interact with α(v)β(3) integrin. to study host cell interactions and rapidly test the ability of antibodies to prevent infection, we produced htnv and puuv pseudovirions on a vesicular stomatitis virus (vsv) core. similar to replication- ... | 2011 | 22209230 |
| infection of hantaan virus strain aa57 leading to pulmonary disease in laboratory mice. | hantaan virus (htnv) is a causative agent of hemorrhagic fever with renal syndrome (hfrs). the pathogenesis of hfrs has not been fully elucidated, mainly due to the lack of a suitable animal model. in laboratory mice, htnv causes encephalitis. however, that symptom is dissimilar to human hantavirus infections. we found that htnv strain aa57 (isolated from apodemus agrarius in far east russia) caused pulmonary disease in 2-week-old icr mice. the clinical signs of the infected mice were piloerecti ... | 2011 | 22044619 |
| hantavirus pulmonary syndrome. | hantavirus pulmonary syndrome (hps) is a severe disease characterized by a rapid onset of pulmonary edema followed by respiratory failure and cardiogenic shock. the hps associated viruses are members of the genus hantavirus, family bunyaviridae. hantaviruses have a worldwide distribution and are broadly split into the new world hantaviruses, which includes those causing hps, and the old world hantaviruses [including the prototype hantaan virus (htnv)], which are associated with a different disea ... | 2011 | 21945215 |
| Hantaan virus surveillance targeting small mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001-2005. | In response to a hemorrhagic fever with renal syndrome case in November 2000, a seasonal rodent-borne disease surveillance program was initiated at Dagmar North Training Area (DNTA), Gyeonggi Province, Republic of Korea. From April 2001-December 2005, 1,848 small mammals were captured. Apodemus agrarius accounted for 92.5%, followed by Mus musculus (3.6%), Crocidura lasiura (2.1%), and Microtus fortis (1.1%). Three species of rodents were found to be antibody-positive (Ab+) for Hantaan virus (HT ... | 2011 | 22129409 |
| identification of three novel ctl epitopes within nucleocapsid protein of hantaan virus. | hantaan virus (htnv) is a member of the hantavirus genus that causes human hemorrhagic fever with renal syndrome (hfrs) in humans. the ctl response seems to play a key role in control of viral infection, but only a few htnv epitopes recognized by the ctls have been reported. herein, we screened a panel of overlapping peptides covering the htnv nucleocapsid protein by elispot assays for those that can elicit ifn-γ production in vitro. three novel cd8(+) ctl epitopes, n197-205 (ryrtavcgl), n245-25 ... | 2011 | 22111596 |
| A Review of Zoonotic Disease Surveillance Supported by the Armed Forces Health Surveillance Center. | The Armed Forces Health Surveillance Center (AFHSC), Division of Global Emerging Infections Surveillance and Response System conducts disease surveillance through a global network of US Department of Defense research laboratories and partnerships with foreign ministries of agriculture, health and livestock development in over 90 countries worldwide. In 2010, AFHSC supported zoonosis survey efforts were organized into four main categories: (i) development of field assays for animal disease survei ... | 2011 | 22128834 |
| Immunogenic epitopes of Hantaviruses' N protein are restricted to conserved regions. | The Bunyaviridae virus family is composed by five genera, of which the Hantavirus genus is one of the most important representatives. Occasionally, these viruses can be transmitted to humans, giving rise to severe diseases that present high mortality rates. We analyzed the amino acid sequences of the nucleocapsid (N) proteins of 34 different hantaviruses to investigate the potential mechanisms involved in immunogenicity against hantaviruses. Immunogenic epitopes described in the literature throu ... | 2012 | 22201821 |
| a phase 1 clinical trial of hantaan virus and puumala virus m-segment dna vaccines for hemorrhagic fever with renal syndrome. | candidate dna vaccines for hemorrhagic fever with renal syndrome expressing the envelope glycoprotein genes of hantaan (htnv) or puumala (puuv) viruses were evaluated in an open-label, single-center phase 1 study consisting of three vaccination groups of nine volunteers. the volunteers were vaccinated by particle-mediated epidermal delivery (pmed) three times at four-week intervals with the htnv dna vaccine, the puuv dna vaccine or both vaccines. at each dosing, the volunteers received 8μg dna/4 ... | 2012 | 22248821 |
| pathogenicity of a natural reassortant hantavirus cgrn9415 in newborn rats and newborn mice. | to better understand the pathogenicity and infectivity of a natural reassortant cgrn9415 generated from hantaan virus (htnv) and seoul virus (seov), cgrn9415, htnv 76-118, and seov l99 were used to infect newborn kunming (km) mice and newborn wistar rats. in km mice, there was no statistic difference between the death rate with cgrn9415 and that with l99, while 76-118 killed all mice even at low dosage; cgrn9415 killed all infected rats like l99 at the dosage of 105 ffu while no death occurred i ... | 2012 | 22258864 |
| showers, sweating and suing: legionnaires' disease and 'new' infections in britain, 1977-90. | legionnaires' disease is now routinely discussed as an 'emerging infectious disease' (eid) and is said to be one of the earliest such diseases to be recognised. it first appeared in 1976 and its cause was identified in 1977, the same year that ebola fever, hantaan virus and campylobacter jejuni arrived. the designation of legionnaires' disease as an eid was retrospective; it was not and could not be otherwise as the category only gained currency in the early 1990s. in this article we reflect on ... | 2012 | 23752984 |
| a recombinant pseudotyped lentivirus expressing the envelope glycoprotein of hantaan virus induced protective immunity in mice. | hantaviruses cause acute hemorrhagic fever with renal syndrome (hfrs). currently, several types of inactivated hfrs vaccines are widely used, however the limited ability of these immunogen to elicit neutralizing antibodies restricts vaccine efficacy. development of an effective vaccine to overcome this weakness is must. | 2013 | 24093752 |
| ifitm-2 and ifitm-3 but not ifitm-1 restrict rift valley fever virus. | we show that interferon-induced transmembrane protein 1 (ifitm-1), ifitm-2, and ifitm-3 exhibit a broad spectrum of antiviral activity against several members of the bunyaviridae family, including rift valley fever virus (rvfv), la crosse virus, andes virus, and hantaan virus, all of which can cause severe disease in humans and animals. we found that rvfv was restricted by ifitm-2 and -3 but not by ifitm-1, whereas the remaining viruses were equally restricted by all ifitms. indeed, at low doses ... | 2013 | 23720721 |
| sustained high level of serum vegf at convalescent stage contributes to the renal recovery after htnv infection in patients with hemorrhagic fever with renal syndrome. | to investigate the role of vascular endothelial growth factor (vegf) in the increased permeability of vascular endothelial cells after hantaan virus (htnv) infection in humans, the concentration of vegf in serum from htnv infected patients was quantified with sandwich elisa. generally, the level of serum vegf in patients was elevated to 607.0 (542.2-671.9) pg/ml, which was dramatically higher compared with healthy controls (p < 0.001). there was a rapid increase of the serum vegf level in all pa ... | 2012 | 23097674 |
| hantaan virus infection induces cxcl10 expression through tlr3, rig-i, and mda-5 pathways correlated with the disease severity. | hantaan virus (htnv) is a major agent causing hemorrhagic fever with renal syndrome (hfrs). although the pathogenesis of hfrs is unclear, some reports have suggested that the abundant production of proinflammatory cytokines and uncontrolled inflammatory responses may contribute to the development of hfrs. cxcl10 is one of these cytokines and is found to be involved in the pathogenesis of many virus infectious diseases. however, the role of cxcl10 in the pathogenesis of hfrs and the molecular reg ... | 2014 | 24701034 |
| mechanistic insight into bunyavirus-induced membrane fusion from structure-function analyses of the hantavirus envelope glycoprotein gc. | hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (hfrs) or of hantavirus pulmonary syndrome (hps), depending on the virus, which are associated with high case fatality rates. there is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein gc, the function of which is essential for virus entry. we desc ... | 2016 | 27783711 |
| screening and identification of an h-2k(b)-restricted ctl epitope within the glycoprotein of hantaan virus. | the cytotoxic t lymphocyte (ctl) response plays a key role in controlling viral infection, but only a few epitopes within the htnv glycoprotein (gp) that are recognized by ctls have been reported. in this study, we identified one murine htnv gp-derived h2-k(b)-restricted ctl epitope in c57bl/6 mice, which could be used to design preclinical studies of vaccines for htnv infection. first, 15 8-mer peptides were selected from the htnv gp amino acid sequence based on a percentile rank of <=1% by ied ... | 2016 | 27933274 |
| antiviral therapy and prevention against hantavirus infections. | hantaviruses are emerging zoonoses hosted by small mammals. in humans, they cause two diseases. hemorrhagic fever with renal syndrome is mainly caused by dobrava-belgrade virus, puumala virus, seoul virus and hantaan virus in asia and europe. on the other hand, the most important causes of hantavirus cardiopulmonary syndrome are sin nombre virus and andes virus in americas. ribavirin yet remains the only licensed drug against the hantavirus infections, but its sufficient antiviral activity remai ... | 2017 | 28105849 |
| the andes virus nucleocapsid protein directs basal endothelial cell permeability by activating rhoa. | andes virus (andv) predominantly infects microvascular endothelial cells (mecs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome (hps). in hps patients, virtually every pulmonary mec is infected, mecs are enlarged, and infection results in vascular leakage and highly lethal pulmonary edema. we observed that mecs infected with the andv hantavirus or expressing the andv nucleocapsid (n) protein showed increased size and permeability by activating the rheb and r ... | 2016 | 27795403 |
| development of an immunochromatography strip test based on truncated nucleocapsid antigens of three representative hantaviruses. | hantaviruses are causative agents of hemorrhagic fever with renal syndrome (hfrs) and nephropathia epidemica (ne) in the old world and hantavirus pulmonary syndrome (hps) in the new world. there is a need for time-saving diagnostic methods. in the present study, recombinant n antigens were used as antigens in an immunochromatography strip (icg) test to detect specific igg antibodies. | 2014 | 24885901 |
| simultaneous detection of igg antibodies associated with viral hemorrhagic fever by a multiplexed luminex-based immunoassay. | viral hemorrhagic fevers (vhfs) are worldwide diseases caused by several kinds of viruses. with the emergence of new viruses, advanced diagnostic methods are urgently needed for identification of vhfs. based on luminex xmap technology, a rapid, sensitive, multi-pathogen and high-throughput method which could simultaneously detect hemorrhagic fever viruses (hfvs) specific igg antibodies was developed. recombinant antigens of nine hfvs including hantaan virus (htnv), seoul virus (seov), puumala vi ... | 2014 | 24631566 |
| a novel sin nombre virus dna vaccine and its inclusion in a candidate pan-hantavirus vaccine against hantavirus pulmonary syndrome (hps) and hemorrhagic fever with renal syndrome (hfrs). | sin nombre virus (snv; family bunyaviridae, genus hantavirus) causes a hemorrhagic fever known as hantavirus pulmonary syndrome (hps) in north america. there have been approximately 200 fatal cases of hps in the united states since 1993, predominantly in healthy working-age males (case fatality rate 35%). there are no fda-approved vaccines or drugs to prevent or treat hps. previously, we reported that hantavirus vaccines based on the full-length m gene segment of andes virus (andv) for hps in so ... | 2013 | 23892100 |
| slit2-robo4 receptor responses inhibit andv directed permeability of human lung microvascular endothelial cells. | hantaviruses nonlytically infect human endothelial cells (ecs) and cause edematous and hemorrhagic diseases. andes virus (andv) causes hantavirus pulmonary syndrome (hps), and hantaan virus (htnv) causes hemorrhagic fever with renal syndrome (hfrs). hantaviruses enhance vascular endothelial growth factor directed ec permeability resulting in the disassembly of inter-endothelial cell adherens junctions (ajs). recent studies demonstrate that slit2 binding to robo1/robo4 receptors on ecs has opposi ... | 2013 | 23702092 |
| andes virus infection of lymphatic endothelial cells causes giant cell and enhanced permeability responses that are rapamycin and vascular endothelial growth factor c sensitive. | hantaviruses primarily infect endothelial cells (ecs) and nonlytically cause vascular changes that result in hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). acute pulmonary edema during hps may be caused by capillary leakage and failure of lymphatic vessels to clear fluids. uniquely regulated lymphatic ecs (lecs) control fluid clearance, although roles for lymphatics in hantavirus disease remain undetermined. here we report that hantaviruses productively inf ... | 2012 | 22696643 |
| induction of hantaan virus-specific immune responses in c57bl/6 mice by immunization with a modified recombinant adenovirus containing the chimeric gene, gcs0.7. | hantavirus glycoprotein gc is one of the main components that contribute to the generation of humoral immune responses, while the nucleocapsid protein (np) is involved in cellular immune responses through the induction of antibody-dependent cytotoxic t cells. in this study, a chimeric gene, gcs0.7, which encodes a fusion protein containing gc and truncated np, was constructed as a candidate for hantaan virus (htnv) vaccine development. the chimeric gene was cloned into an adenoviral vector in co ... | 2013 | 23783439 |
| a two-tube multiplex real-time rt-pcr assay for the detection of four hemorrhagic fever viruses: severe fever with thrombocytopenia syndrome virus, hantaan virus, seoul virus, and dengue virus. | the aim of this study was to develop and evaluate a two-tube multiplex real-time rt-pcr assay for the detection and identification of four viral hemorrhagic fever (vhf) pathogens, severe fever with thrombocytopenia syndrome virus (sftsv), hantaan virus (htnv), seoul virus (seov), and dengue virus (denv), from human clinical samples. the two-tube multiplex real-time rt-pcr assay we developed has a sensitivity of 10 copies/μl for each of the targets, and the performance was linear within the range ... | 2013 | 23532380 |
| hantavirus infections. | over the past few decades understanding and recognition of hantavirus infection has greatly improved worldwide, but both the amplitude and the magnitude of hantavirus outbreaks have been increasing. several novel hantaviruses with unknown pathogenic potential have been identified in a variety of insectivore hosts. with the new hosts, new geographical distributions of hantaviruses have also been discovered and several new species were found in africa. hantavirus infection in humans can result in ... | 2015 | 24750436 |
| dobrava-belgrade hantavirus from germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. | dobrava-belgrade virus (dobv) is a european hantavirus causing hemorrhagic fever with renal syndrome (hfrs) in humans with fatality rates of up to 12%. dobv-associated clinical cases typically occur also in the northern part of germany where the virus is carried by the striped field mouse (apodemus agrarius). however, the causative agent responsible for human illness has not been previously isolated. | 2012 | 22545121 |
| immunogenicity of a multi-epitope dna vaccine against hantavirus. | hemorrhagic fever with renal syndrome (hfrs) is a severe epidemic disease caused by hantaviruses including hantaan virus (htnv), seoul virus (seov), dobrava virus (dobv) and puumala virus. three of the four hfrs hantaviruses, htnv, seov, and puuv are found in china. currently, there is no effective strategy available to reduce infection risk. in this study, we constructed a multi-epitope chimeric dna vaccine that encodes expressing 25 glycoprotein epitopes from seov, htnv and puuv (designated as ... | 2012 | 22426376 |
| phosphorylation of the nucleocapsid protein of hantaan virus by casein kinase ii. | hantaanvirus (htnv) is the prototype of the genus hantavirus, which belongs to the family bunyaviridae. hantaviruses are carried and transmitted by rodents and are known to cause two serious disease syndromes in humans i.e., hemorrhagic fever with renal syndrome (hfrs) and the hantavirus pulmonary syndrome (hps). htnv is an enveloped virus that contains a tripartite genome consisting of three negative-sense rna segments (l, m, s), and the s and m segment of htnv, respectively, encode the viral n ... | 2015 | 25935306 |
| rapid, whole blood diagnostic test for detecting anti-hantavirus antibody in rats. | hantavirus is a causative agent of rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome. seoul virus (seov) is a causative agent of urban and laboratory rat-associated hfrs worldwide. surveillance of rodents has been done mainly by serological detection of hantavirus-specific antibodies by enzyme linked immunosorbent assay (elisa) and immunofluorescent antibody assay (ifa). an immunochromatographic (icg) test was developed with the n-termina ... | 2013 | 23684845 |
| detection of imjin virus and seoul virus in crocidurine shrews in shandong province, china. | recently, hantaviruses have been discovered in insectivores in europe, asia, africa, and north america. imjin virus (mjnv) was first isolated from the lung tissues of ussuri white-toothed shrew (crocidura lasiura) from south korea in 2009. we aim to detect the species and prevalence of insectivore- and rodent-borne hantaviruses in shrews and rodents. | 2017 | 28287930 |
| insufficient efficacy and safety of intravenous ribavirin in treatment of haemorrhagic fever with renal syndrome caused by puumala virus. | intravenous ribavirin has been reported to be an effective treatment for haemorrhagic fever with renal syndrome (hfrs) caused by hantaan virus in asia. however, its therapeutic benefits for hfrs caused by puumala virus (puuv) in europe are still unknown. | 2017 | 28276794 |
| the long noncoding rna neat1 exerts anti-hantaviral effects by acting as a positive feedback for rig-i signaling. | hantavirus infection, which causes zoonotic diseases with a high mortality rate in humans, has long been a global public health concern. over the past decades, accumulating evidence suggests that long noncoding rnas (lncrnas) play key regulatory roles in innate immunity. however, the involvement of host lncrnas in hantaviral control remains uncharacterized. in this study, we identified the lncrna, neat1, as a vital antiviral modulator. neat1 was dramatically upregulated after hantaan virus (htnv ... | 2017 | 28202761 |
| anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome. | zoonoses are increasingly recognized as an important burden on global public health in the 21st century. high-resolution, long-term field studies are critical for assessing both the baseline and future risk scenarios in a world of rapid changes. we have used a three-decade-long field study on hantavirus, a rodent-borne zoonotic pathogen distributed worldwide, coupled with epidemiological data from an endemic area of china, and show that the shift in the ecological dynamics of hantaan virus was c ... | 2017 | 28141833 |
| [pathomorphism of hantavirus infection under prolonged heat stress]. | to provide the morphological characteristics of experimental hantavirus infection under heat stress conditions to identify the possibilities of its modeling in resistant laboratory animals. | 2016 | 28139601 |
| appearance of renal hemorrhage in adult mice after inoculation of patient-derived hantavirus. | hemorrhagic fever with renal syndrome (hfrs) caused by hantavirus infection is characterized by fever, renal dysfunction and hemorrhage. an animal model mimicking symptoms of hfrs remains to be established. in this study, we evaluated the pathogenicity of an hfrs patient-derived hantaan virus (htnv) in adult mice. | 2017 | 28122569 |
| interferon-induced transmembrane protein 3 inhibits hantaan virus infection, and its single nucleotide polymorphism rs12252 influences the severity of hemorrhagic fever with renal syndrome. | hantaan virus (htnv) causes hemorrhagic fever with renal syndrome (hfrs). previous studies have identified interferon-induced transmembrane proteins (ifitms) as an interferon-stimulated gene family. however, the role of ifitms in htnv infection is unclear. in this study, we observed that ifitm3 single nucleotide polymorphisms (snp) rs12252 c allele and cc genotype associated with the disease severity and htnv load in the plasma of hfrs patients. in vitro experiments showed that the truncated pro ... | 2016 | 28096800 |
| incorporation of gm-csf or cd40l enhances the immunogenicity of hantaan virus-like particles. | a safe and effective hantaan virus (htnv) vaccine is highly desirable because htnv causes an acute and often fatal disease (hemorrhagic fever with renal syndrome, hfrs). since the immunity of the inactivated vaccine is weak and the safety is poor, htnv virus-like particles (vlps) offer an attractive and safe alternative. these particles lack the viral genome but are perceived by the immune system as virus particles. we hypothesized that adding immunostimulatory signals to vlps would enhance thei ... | 2016 | 28066721 |
| corrigendum: hemorrhagic fever with renal syndrome: pathogenesis and clinical picture. | [this corrects the article on p. 1 in vol. 6, pmid: 26870699.]. | 2016 | 27981038 |
| cytokine response to hantaan virus infection in patients with hemorrhagic fever with renal syndrome. | hantaan virus (htnv) infection of the human body causes a severe acute infectious disease known as hemorrhagic fever renal syndrome (hfrs). the aim of this study was to correlate patient cytokine profiles to hfrs severity. in this study, we discuss the clinical significance of evaluating hfrs treatment outcomes using cytokine information. the levels of 18 cytokines were quantitatively determined in three groups: 34 htnv igm+ cases, 63 htnv igm- negative cases, and 78 healthy volunteers. the leve ... | 2016 | 27943332 |
| sequence-independent, single-primer amplification next-generation sequencing of hantaan virus cell culture-based isolates. | hantaan virus (htnv), identified in the striped field mouse (apodemus agrarius), belongs to the genus hantavirus of the family bunyaviridae and contains tripartite rna genomes, small (s), medium (m), and large (l) segments. htnv is a major causative for hemorrhagic fever with renal syndrome (hfrs) with fatality rates ranging from 1% to 15% in the republic of korea (rok) and china. defining of htnv whole-genome sequences and isolation of the infectious particle play a critical role in the charact ... | 2017 | 27895275 |
| the assessment of hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest china. | xianyang city is one of the main hemorrhagic fever with renal syndrome (hfrs) epidemic areas in northwest china. although the hfrs immunity program has been provided in this city, hfrs is still occurred every year. in order to implement the vaccination program effectively and to control hfrs, the analysis of antibody responses specific to hantaan virus (htnv) in individuals after vaccination is essential. in this study, a total of 100 subjects were divided into 5 groups: unvaccinated, 1, 3, 29 a ... | 2016 | 27824286 |
| type inactivated bivalent hantavirus vaccines using dual fluorescence quantitative real-time pcr: establishment and evaluation. | to establish a dual fluorescence quantitative real-time polymerase chain reaction (dfqrt-pcr) method for typing inactivated bivalent vaccines of hantaan virus (htnv, type i) and seoul virus (seov, type ii) found in china. primers and probes were designed based on s segment of the hantavirus. fam and hex were added to the probes for the type i and type ii vaccines, respectively. the s fragments were cloned into the pmd18-t vector to create pmd18-t/htnv and pmd18-t/seov plasmids, respectively. the ... | 2017 | 27301695 |
| prevalence of hemorrhagic fever with renal syndrome in qingdao city, china, 2010-2014. | hemorrhagic fever with renal syndrome (hfrs) was considered to be transmitted by apodemus agrarius and rattus norvegicus, the principal animal hosts of hantaan virus and seoul virus, respectively. the aim of this study is to determine the correlation of hfrs incidence with capture rate and hantavirus infection rate of rodent species in qingdao city, china. we collected hfrs patients' information and captured field and residential rodents in qingdao city, china from 2010 to 2014. the correlations ... | 2016 | 27786303 |
| prediction of b cell epitopes among hantavirus strains causing hemorragic fever with renal syndrome. | hantavirus infections are now recognized to be a global problem. the hantaviruses include several genotypic variants of the virus with different distributions in varying geographical regions. the virus genotypes seem to segregate in association with certain manifestations specific for each syndrome. they primarily include hfrs, hcps, febrile illness with or without mild involvement of renal diseases. in the course of our study on hantavirus etiology of febrile illnesses, we recovered a hantaviru ... | 2017 | 27748540 |
| structure and function of hla-a*02-restricted hantaan virus cytotoxic t-cell epitope that mediates effective protective responses in hla-a2.1/k(b) transgenic mice. | hantavirus infections cause severe emerging diseases in humans and are associated with high mortality rates; therefore, they have become a global public health concern. our previous study showed that the cd8(+) t-cell epitope aa129-aa137 (fvvpillka, fa9) of the hantaan virus (htnv) nucleoprotein (np), restricted by human leukocyte antigen (hla)-a*02, induced specific cd8(+) t-cell responses that controlled htnv infection in humans. however, the in vivo immunogenicity of peptide fa9 and the effec ... | 2016 | 27551282 |
| construction and immunological characterization of cd40l or gm-csf incorporated hantaan virus like particle. | infection of hantaan virus (htnv) usually causes hemorrhagic fever with renal syndrome (hfrs). china has the worst epidemic incidence of hfrs as well as high fatality. inactivated whole virus has been used for hfrs vaccination, however there are still problems such as safety concerns. cd40 ligand (cd40l) and granulocyte macrophage colony-stimulating factor (gm-csf) are well-known immune stimulating molecules that can enhance antigen presenting, lymphocytes activation and maturation, incorporatio ... | 2016 | 27542281 |
| development of a sybr-green ⅰ quantitative pcr assay for the detection and genotyping of different hantaviruses. | hemorrhagic fever with renal syndrome (hfrs) is a severe, viral zoonotic disease which occurs worldwide, particularly in asia and europe. in china, the hantaan virus (htnv) and the seoul virus (seov) are known to be the most prevalent causative agents of hfrs. since no protective vaccines or effective treatments are available for human use, accurate and reliable diagnostic methods are essential for disease surveillance. in the present study, the viral loads in cell culture supernatant, infected ... | 2016 | 27430149 |
| genetic diversity and reassortment of hantaan virus tripartite rna genomes in nature, the republic of korea. | hantaan virus (htnv), a negative sense tripartite rna virus of the family bunyaviridae, is the most prevalent hantavirus in the republic of korea (rok). it is the causative agent of hemorrhagic fever with renal syndrome (hfrs) in humans and maintained in the striped field mouse, apodemus agrarius, the primary zoonotic host. clinical hfrs cases have been reported commonly in hfrs-endemic areas of gyeonggi province. recently, the death of a member of the rok military from gangwon province due to h ... | 2016 | 27315053 |
| comparative structural and functional analysis of bunyavirus and arenavirus cap-snatching endonucleases. | segmented negative strand rna viruses of the arena-, bunya- and orthomyxovirus families uniquely carry out viral mrna transcription by the cap-snatching mechanism. this involves cleavage of host mrnas close to their capped 5' end by an endonuclease (en) domain located in the n-terminal region of the viral polymerase. we present the structure of the cap-snatching en of hantaan virus, a bunyavirus belonging to hantavirus genus. hantaan en has an active site configuration, including a metal co-ordi ... | 2016 | 27304209 |
| phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex pcr-based next generation sequencing. | emerging and re-emerging infectious diseases caused by rna viruses pose a critical public health threat. next generation sequencing (ngs) is a powerful technology to define genomic sequences of the viruses. of particular interest is the use of whole genome sequencing (wgs) to perform phylogeographic analysis, that allows the detection and tracking of the emergence of viral infections. hantaviruses, bunyaviridae, cause hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome ... | 2016 | 27221218 |
| genetic characterization of hantaviruses isolated from rodents in the port cities of heilongjiang, china, in 2014. | hantavirus is a tripartite negative-sense rna virus. it can infect humans through contaminated rodent excreta and causes two types of fatal human diseases: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). china exhibits the highest hfrs occurrence rate in the world, and the heilongjiang area is one of the most severely infected regions. | 2016 | 27038799 |
| a case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. | | 2016 | 27012169 |
| specific interference shrna-expressing plasmids inhibit hantaan virus infection in vitro and in vivo. | to investigate the antiviral effects of vectors expressing specific short hairpin rnas (shrnas) against hantaan virus (htnv) infection in vitro and in vivo. | 2016 | 26972493 |
| ckd and infectious diseases in asia pacific: challenges and opportunities. | the exact number of patients with chronic kidney disease (ckd) in asia pacific is uncertain. in numeric terms, the region is home to the largest population of patients with untreated chronic kidney failure. the climatic, geographic, social, cultural, economic, and environmental diversity within this region is higher than in any other part of the world. large parts of the region face a climate-related burden of infectious diseases. infections contribute to the development and progression of ckd a ... | 2016 | 26943982 |
| the experimental research (in vitro) of carrageenans and fucoidans to decrease activity of hantavirus. | the effect of carrageenans and fucoidans on the activity of hantavirus is studied. it has been found that among carrageenans a significant antiviral effect is exerted by the ι-type, which decreases the viral titer by 2.5 log focus forming units per ml; among fucoidans, by a preparation from laminaria cichorioides, which reduces the number of infected cells from 27.0 to 5.3 after pretreatment of both the macrophage culture and hantavirus. the antiviral effect of fucoidan from laminaria japonica i ... | 2016 | 26943130 |
| detection of hantaan virus rna from anti-hantaan virus igg seronegative rodents in an area of high endemicity in republic of korea. | hantaan virus (htnv), of the family bunyaviridae, causes hemorrhagic fever with renal syndrome (hfrs) in humans. although the majority of epidemiologic studies have found that rodents are seropositive for hantavirus-specific immunoglobulin, the discovery of hantavirus rna in seronegative hosts has led to an investigation of the presence of htnv rna in rodents captured in hfrs endemic areas. htnv rna was detected in seven (3.8%) of 186 anti-htnv igg seronegative rodents in republic of korea (rok) ... | 2016 | 26917012 |
| hemorrhagic fever with renal syndrome: pathogenesis and clinical picture. | hantaan virus (htnv) causes hemorrhagic fever with renal syndrome (hfrs), which is a zoonosis endemic in eastern asia, especially in china. the reservoir host of htnv is field mouse (apodemus agraricus). the main manifestation of hfrs, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. in this paper, we review the current knowledge of the pathogenesis of hfrs including virus factor, immunity factor and host genetic factors. furthermore, the treatment a ... | 2016 | 26870699 |
| prevalence of hemorrhagic fever with renal syndrome in yiyuan county, china, 2005-2014. | hemorrhagic fever with renal syndrome (hfrs) is highly endemic in mainland china, where human cases account for 90 % of the total global cases. yiyuan county is one of the most serious affected areas in china. therefore, there is an urgent need for monitoring and predicting hfrs incidence in yiyuan to make the control of hfrs more effective. | 2016 | 26852019 |
| long-term immunogenicity and safety of inactivated hantaan virus vaccine (hantavax™) in healthy adults. | hemorrhagic fever with renal syndrome is a serious health problem in eurasian countries, including korea and china. this study evaluated the long-term immunogenicity and safety of formalin-inactivated hantaan virus vaccine (hantavax™). | 2016 | 26826547 |
| hemorrhagic fever with renal syndrome, zibo city, china, 2006-2014. | analysis of hemorrhagic fever with renal syndrome cases in zibo city, china, during 2006-2014 showed that it occurred year-round. peaks in spring and fall/winter were caused by hantaan and seoul viruses, respectively. rodent hosts were the striped field mouse for hantaan virus and the brown rat and house mouse for seoul virus. | 2016 | 26812444 |