Publications

creutzfeldt-jakob disease in france: i. retrospective study of the paris area during the ten-year period 1968-1977.	a systematic search for cases of creutzfeldt-jakob disease occurring in the ten-year period 1968 through 1977 was conducted in the city of paris and surrounding departments which comprise the greater paris area. fifty-six cases were found among the total population of approximately 10 million inhabitants, with a maximum incidence of 1.1 cases per year per million people in the densely populated city of paris and a progressively lower incidence in the less heavily populated suburban and rural are ...	1979	371521
[epidemiology of creutzfeldt-jakob disease in the paris area].	the area studied includes the city of paris and the neighboring departments of val-d'oise, seine-saint-denis, hauts-de-seine, yvelines, essonne, val-de-marne, and seine-et-marne. case finding methods and diagnostic criteria are defined. the temporal and spatial distribution of cases is described, and the absence of case clustering is noted. incidence per million people (per year) was found to be 1,09 in the city, 0,55 in the adjacent departments, and 0,25 in the peripheral departments. these res ...	1978	382326
creutzfeldt-jakob disease in france: iii. epidemiological study of 170 patients dying during the decade 1968--1977.	systematic search for creutzfeldt-jakob disease (cjd) in france yielded a total of 170 patients dying between 1968 and 1977. the overall annual mortality rate from cjd for france was 0.32 case per million persons, with by far the highest rate (1.33 cases per million) in the most densely populated parts of paris. a highly significant correlation between population density and the mortality rate of cjd in the paris urban agglomeration was consistent with the hypothesis of human-to human disease tr ...	1979	391142
[creutzfeldt-jacob disease in continental france. retrospective study from 1968 to 1977].	during the decade 1968-1977, 170 cases of creutzfeldt-jakob disease were found in france. the clinical features of 124 neuropathologically-verified cases are summarized and a multi-factor analysis performed to obtain the most frequent combinations of signs and symptoms. certain exceptional features are discussed. the annual mortality rate during this period was 0.32 cases per million for the whole of france, and 0.69 cases per million for the paris metropolitan area. preliminary totals for 1978 ...	1979	395612
the question of clustering of creutzfeldt-jakob disease.	clustering of creutzfeldt-jakob disease has been reported in several countries. the authors review these reports, and they describe their statistical analysis of clustering among 329 cases that died in france during 1968-1982. paris was found to have a much higher case rate than the rest of france, while some large areas in the north and west had remarkably few cases relative to their populations. no rural clusters were identified. a number of explanations for regional variations in case rates a ...	2009	2642649
the epidemiology of creutzfeldt-jakob disease: conclusion of a 15-year investigation in france and review of the world literature.	during the 15-year period 1968-1982, a total of 329 patients dying of creutzfeldt-jakob disease (cjd) were identified in continental france. annual mortality rates stabilized at 0.5 to 0.6 cases per million (1.1 to 1.2 cases per million in paris). six percent of cases were familial. although the frequency of cjd was related to population density, no contacts could be established among the great majority of patients. no association with socioeconomic factors, preceding trauma or surgery (exceptin ...	1987	3295589
[creutzfeldt-jakob disease in the paris area: ethnic origin of the patients].	twenty six (27 p. 100) of 96 patients dying from creutzfeldt-jakob disease in the paris metropolitan area between 1968 and 1982 were born in foreign countries although the proportion of foreign-born residents account for only 15 p. 100 of the population. the annual mortality rate of creutzfeldt-jakob's disease in this group of foreign-born cases (1.33 per million) was twice that of french-born residents (0.64 per million). twenty of the 26 foreign-born cases originated from countries surrounding ...	1986	3523686
correlation between population density and the frequency of creutzfeldt-jakob disease in france.	epidemiologic studies of creutzfeldt-jakob disease (cjd) in countries throughout the world have consistently shown higher urban than national disease frequencies, but this finding has usually been ascribed to case-finding artefact. a detailed analysis has now been completed of annual mortality rates of cjd in france, based on a systematic study of 255 consecutive cases dying during the period 1968-1980, of whom 85 resided in the paris metropolitan area. in the country as a whole, the frequency o ...	1983	6348216
[creutzfeldt-jakob disease in the paris metropolitan area. study of annual mortality in different density zones in relation to the age of population].	a study of all patients with creutzfeldt-jakob disease in the paris metropolitan area dying during the 13 year period 1968-1980 reveals a positive correlation between annual mortality and population density, that is independent of variation in population age structure. this observation is consistent with the hypothesis of random interhuman-disease transmission.	1984	6371675
epidemiologic comparisons between creutzfeldt-jakob disease and scrapie in france during the 12-year period 1968-1979.	systematic investigation of the occurrence of scrapie in france revealed that between 1968 and 1979 the disease has been diagnosed in a total of 145 flocks, in virtually every region where sheep are raised. the geographic distribution of scrapie-affected flocks was unrelated to the residential location of patients dying of creutzfeldt-jakob disease (cjd) during this period, arguing against direct contact or indirect vector transmission of the disease to humans. regional lamb consumption was not ...	1981	7024478
[creutzfeldt-jakob disease in france: an epidemiological update (author's transl)].	we report here the results of a prospective epidemiological study of creutzfeldt-jakob disease in continental france during the years 1978-80, extending a retrospective study of the decade 1968-1977 previously reported. the new annual mortality figures are 0.53 cases per million people for france as a whole, and 1,01 cases per million people for the paris metropolitan area. the correlation between mortality rate and population density persists in the parisian area, and is not related to differen ...	1982	7048483
[non-familial creutzfeldt-jakob disease: a study of 53 cases].	creutzfeldt-jakob disease (cjd) is the most frequent human spongiform encephalopathy. we have analyzed 53 cases of definite non familial cjd over a study period of 28 years. all were autopsied in the same neuropathological unit. clinical and epidemiological data were in accordance with previous studies: low incidence of cjd under the age of 40, high incidence around the sixty years of age (26%) a sex ratio at 0.65 and high frequency of myoclonus, dementia and cerebellar ataxia during evolution ( ...	2000	10891795
the population distribution of the met allele at the prnp129 polymorphism (a high risk factor for creutzfeldt-jakob disease) in various regions of france and in west europe.	the present study has been conducted to ascertain the level of allelic variation at codon 129 of the prion protein gene in france. six french populations have been studied (paris, lille, rennes, chambéry, grasse and perpignan), totalling 1374 normal subjects. mean heterozygosity in france is 46.5%, and the mean met 129 allele (a high risk susceptibility factor for creutzfeldt-jakob disease) is 0.674. there is a genetic heterogeneity (chi(2)=38.44, p<0.001) between the six populations compared, a ...	2005	15639746