Publications

natural mutations in the receptor binding domain of spike glycoprotein determine the reactivity of cross-neutralization between palm civet coronavirus and severe acute respiratory syndrome coronavirus.	the severe acute respiratory syndrome (sars) outbreak of 2002 and 2003 occurred as a result of zoonotic transmission. coronavirus (cov) found in naturally infected palm civet (civet-cov) represents the closest genetic relative to sars-cov, but the degree and the determinants of cross-neutralization among these viruses remain to be investigated. studies indicate that the receptor binding domain (rbd) of the sars-cov spike (s) glycoprotein contains major determinants for viral entry and neutraliza ...	2007	17314167
ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related rhinolophus bat coronavirus in china reveal bats as a reservoir for acute, self-limiting infection that allows recombination events.	despite the identification of severe acute respiratory syndrome-related coronavirus (sarsr-cov) in rhinolophus chinese horseshoe bats (sarsr-rh-batcov) in china, the evolutionary and possible recombination origin of sarsr-cov remains undetermined. we carried out the first study to investigate the migration pattern and sarsr-rh-batcov genome epidemiology in chinese horseshoe bats during a 4-year period. of 1,401 chinese horseshoe bats from hong kong and guangdong, china, that were sampled, sarsr- ...	2010	20071579
ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related rhinolophus bat coronavirus in china reveal bats as a reservoir for acute, self-limiting infection that allows recombination events.	despite the identification of severe acute respiratory syndrome-related coronavirus (sarsr-cov) in rhinolophus chinese horseshoe bats (sarsr-rh-batcov) in china, the evolutionary and possible recombination origin of sarsr-cov remains undetermined. we carried out the first study to investigate the migration pattern and sarsr-rh-batcov genome epidemiology in chinese horseshoe bats during a 4-year period. of 1,401 chinese horseshoe bats from hong kong and guangdong, china, that were sampled, sarsr- ...	2010	20071579