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from the centers for disease control and prevention. update: outbreak of severe acute respiratory syndrome--worldwide, 2003. 200312697782
taiwan left isolated in fight against sars. 200312700727
control measures for severe acute respiratory syndrome (sars) in taiwan.as of april 14, 2003, taiwan had had 23 probable cases of severe acute respiratory syndrome (sars), 19 of which were imported. taiwan isolated all 23 patients in negative-pressure rooms; extensive personal protective equipment was used for healthcare workers and visitors. for the first 6 weeks of the sars outbreak, recognized spread was limited to one healthcare worker and three household contacts.200312781013
from the centers for disease control and prevention. severe acute respiratory syndrome--taiwan, 2003. 200312799395
severe acute respiratory syndrome--taiwan, 2003.on april 22, 2003, the taiwan department of health (doh) was notified of seven cases of severe acute respiratory syndrome (sars) among health-care workers (hcws) at a large municipal hospital in taipei (hospital a). subsequent cases at eight hospitals have been associated with exposures at hospital a. previously, all reported cases had been associated with persons recently returning to taiwan from sars-affected regions. this report summarizes epidemiologic findings of the outbreak in taiwan and ...200312807078
[severe acute respiratory syndrome (sars)].severe acute respiratory syndrome (sars) is a viral disease, observed primarily in southern china in november 2002, with variable flu-like symptoms and pneumonia, in approx. 5% leading to death from respiratory distress syndrome (rds). the disease was spread over more than 30 states all over the globe by sars-virus-infected travelers. who and cdc received first information about a new syndrome by the end of february 2003, after the first cases outside the republic of china had been observed. a c ...200312811416
update: severe acute respiratory syndrome--united states, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates reported sars cases worldwide and in the united states, and summarizes changes in travel recommendations for beijing and taiwan, where travel advisories have been downgraded to travel alerts.200312844079
association of hla class i with severe acute respiratory syndrome coronavirus infection.the human leukocyte antigen (hla) system is widely used as a strategy in the search for the etiology of infectious diseases and autoimmune disorders. during the taiwan epidemic of severe acute respiratory syndrome (sars), many health care workers were infected. in an effort to establish a screening program for high risk personal, the distribution of hla class i and ii alleles in case and control groups was examined for the presence of an association to a genetic susceptibly or resistance to sars ...200312969506
the threat of severe acute respiratory syndrome (sars).severe acute respiratory syndrome (sars) is a recently recognized infectious disease associated with severe morbidity and mortality. it presents with non-specific signs and symptoms and because no definitive laboratory test is readily available, it poses a great risk to healthcare workers as well as difficulty in quarantine. the global response has been coordinated and enthusiastic in trying to understand and control this disease. severe acute respiratory syndrome poses a threat to the caribbean ...200312974057
microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, taiwan.the genome of one taiwanese severe acute respiratory syndrome-associated coronavirus (sars-cov) strain (tw1) was 29,729 nt in length. viral rna may persist for some time in patients who seroconvert, and some patients may lack an antibody response (immunoglobulin g) to sars-cov <21 days after illness onset. an upsurge of antibody response was associated with the aggravation of respiratory failure.200314519257
taiwanese scientists find genetic link to sars. 200314595411
molecular epidemiology of sars--from amoy gardens to taiwan. 200314602893
infectious diseases. second lab accident fuels fears about sars. 200414704402
characterization of severe acute respiratory syndrome coronavirus genomes in taiwan: molecular epidemiology and genome evolution.since early march 2003, the severe acute respiratory syndrome (sars) coronavirus (cov) infection has claimed 346 cases and 37 deaths in taiwan. the epidemic occurred in two stages. the first stage caused limited familial or hospital infections and lasted from early march to mid-april. all cases had clear contact histories, primarily from guangdong or hong kong. the second stage resulted in a large outbreak in a municipal hospital, and quickly spread to northern and southern taiwan from late apri ...200414983045
serologic and molecular biologic methods for sars-associated coronavirus infection, taiwan.severe acute respiratory syndrome (sars) has raised a global alert since march 2003. after its causative agent, sars-associated coronavirus (sars-cov), was confirmed, laboratory methods, including virus isolation, reverse transcriptase-polymerase chain reaction (rt-pcr), and serologic methods, have been quickly developed. in this study, we evaluated four serologic tests ( neutralization test, enzyme-linked immunosorbent assay [elisa], immunofluorescent assay [ifa], and immunochromatographic test ...200415030702
sars in healthcare facilities, toronto and taiwan.the healthcare setting was important in the early spread of severe acute respiratory syndrome (sars) in both toronto and taiwan. healthcare workers, patients, and visitors were at increased risk for infection. nonetheless, the ability of individual sars patients to transmit disease was quite variable. unrecognized sars case-patients were a primary source of transmission, and early detection and intervention were important to limit spread. strict adherence to infection control precautions was ess ...200415200808
sars in hospital emergency room.thirty-one cases of severe acute respiratory syndrome (sars) occurred after exposure in the emergency room at the national taiwan university hospital. the index patient was linked to an outbreak at a nearby municipal hospital. three clusters were identified over a 3-week period. the first cluster (5 patients) and the second cluster (14 patients) occurred among patients, family members, and nursing aids. the third cluster (12 patients) occurred exclusively among healthcare workers. six healthcare ...200415200809
clinical manifestations, laboratory findings, and treatment outcomes of sars patients.clinical and laboratory data on severe acute respiratory syndrome (sars), particularly on the temporal progression of abnormal laboratory findings, are limited. we conducted a prospective study on the clinical, radiologic, and hematologic findings of sars patients with pneumonia, who were admitted to national taiwan university hospital from march 8 to june 15, 2003. fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. twenty-four patients had various un ...200415200814
infection control and sars transmission among healthcare workers, taiwan.this study found infrequent transmission of severe acute respiratory syndrome (sars) coronavirus to healthcare workers involved in the care of the first five case-patients in taiwan, despite a substantial number of unprotected exposures. nonetheless, given that sars has been highly transmissible on some occasions, we still recommend strict precautions.200415200825
sars exposure and emergency department workers.of 193 emergency department workers exposed to severe acute respiratory syndrome (sars), 9 (4.7%) were infected. pneumonia developed in six workers, and assays showed anti-sars immunoglobulin (ig) m and igg. the other three workers were igm-positive and had lower igg titers; in two, mild illness developed, and one remained asymptomatic.200415207066
sars epidemiology modeling. 200415224675
development and evaluation of an efficient 3'-noncoding region based sars coronavirus (sars-cov) rt-pcr assay for detection of sars-cov infections.the severe acute respiratory syndrome (sars) epidemic originating from china in 2002 was caused by a previously uncharacterized coronavirus that could be identified by specific rt-pcr amplification. efforts to control future sars outbreaks depend on the accurate and early identification of sars-cov infected patients. a real-time fluorogenic rt-pcr assay based on the 3'-noncoding region (3'-ncr) of sars-cov genome was developed as a quantitative sars diagnostic tool. the ideal amplification effic ...200415234807
severe acute respiratory syndrome (sars) and the gdp. part i : epidemiology, virology, pathology and general health issues.the health profession faces a new challenge with the emergence of a novel viral disease severe acute respiratory syndrome (sars), a form of atypical pneumonia caused by a coronavirus termed sars-cov. this highly infectious disease has spread through 32 countries, infecting more than 8,400 patients with over 790 deaths in just over 6 months. over one quarter of those infected were unsuspecting healthcare workers. the major transmission mode of sars-coronavirus appears to be through droplet spread ...200415272339
sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome.severe acute respiratory syndrome (sars) is a newly emerging infectious disease. to describe the hepatic injury caused by this disease, we report the sequential changes of serum transaminase in probable sars patients during a hospital outbreak in southern taiwan. from april to june, 2003, 52 probable sars patients were hospitalized. serial serum aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were retrospectively analyzed and hepatitis b surface antigen (hbsag) was als ...200415306699
emergency medical services utilization during an outbreak of severe acute respiratory syndrome (sars) and the incidence of sars-associated coronavirus infection among emergency medical technicians.this was a study to evaluate the utilization of emergency medical services (ems) systems during the outbreak of severe acute respiratory syndrome (sars), and to assess the incidence of infection among emergency medical technicians (emts).200415347538
diarrhea in medical care workers with severe acute respiratory syndrome.several known coronavirus species cause a variety of diseases, including respiratory or enteric diseases. the purpose of this study was to investigate the interesting enteric symptoms of the medical care workers who were evidently infected with sars by means of respiratory transmission.200415492605
quantitation of severe acute respiratory syndrome coronavirus genome by real-time polymerase chain reaction assay using minor groove binder dna probe technology.the ability to rapidly recognize severe acute respiratory syndrome coronavirus (sars-cov) as a cause of infections is critical to quickly limiting further spread of the disease. a rapid, sensitive, and specific laboratory diagnostic test is needed to confirm outbreaks of sars-cov infection and distinguish it from other diseases that can cause similar clinical symptoms. an improved taqman technology using minor groove binder (mgb) probes was used to detect and quantify sars-cov in suspected patie ...200415497005
an interferon-gamma-related cytokine storm in sars patients.fourteen cytokines or chemokines were analyzed on 88 rt-pcr-confirmed severe acute respiratory syndrome (sars) patients. ifn-gamma, il-18, tgf-beta, il-6, ip-10, mcp-1, mig, and il-8, but not of tnf-alpha, il-2, il-4, il-10, il-13, or tnfri, were highly elevated in the acute phase sera of taiwan sars patients. ifn-gamma was significantly higher in the ab(+) group than in the ab(-) group. ifn-gamma, il-18, mcp-1, mig, and ip-10 were already elevated at early days post fever onset. furthermore, le ...200515602737
detection of severe acute respiratory syndrome coronavirus rna in plasma during the course of infection.we examined severe acute respiratory syndrome-associated coronavirus (sars-cov) rna in plasma of 32 patients (probable sars cases) by a quantitative real-time reverse transcription-pcr assay and reported that the highest detection rate, 75%, was found between day 5 and day 7 of illness, followed by rates of 64, 50, and 38% found between day 8 and day 11, day 2 and day 4, and day 12 and day 16, respectively. analysis of sequential sars-cov load in plasma from six cases revealed different patterns ...200515695719
phylogenetic analysis and sequence comparisons of structural and non-structural sars coronavirus proteins in taiwan.taiwan experienced a large number of severe acute respiratory syndrome (sars) viral infections between march and july 2003; by september of that year, 346 sars cases were confirmed by rt-pcr or serological tests. in order to better understand evolutionary relationships among sars coronaviruses (scovs) from different international regions, we performed phylogenetic comparisons of full-length genomic and protein sequences from 45 human scovs (including 12 from taiwan) and two civet scovs. all the ...200415737918
quarantine for sars, taiwan.during the 2003 outbreak of severe acute respiratory syndrome (sars) in taiwan, >150,000 persons were quarantined, 24 of whom were later found to have laboratory-confirmed sars-coronavirus (sars-cov) infection. since no evidence exists that sars-cov is infective before the onset of symptoms and the quarantined persons were exposed but not symptomatic, we thought the quarantine's effectiveness should be investigated. using the taiwan quarantine data, we found that the onset-to-diagnosis time of p ...200515752447
immunohistochemical, in situ hybridization, and ultrastructural localization of sars-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in taiwan.this article describes the pathological studies of fatal severe acute respiratory syndrome (sars) in a 73-year-old man during an outbreak of sars in taiwan, 2003. eight days before onset of symptoms, he visited a municipal hospital that was later identified as the epicenter of a large outbreak of sars. on admission to national taiwan university hospital in taipei, the patient experienced chest tightness, progressive dyspnea, and low-grade fever. his condition rapidly deteriorated with increasing ...200515791576
molecular epidemiology of severe acute respiratory syndrome-associated coronavirus infections in taiwan.in 2003, taiwan experienced a series of outbreaks of severe acute respiratory syndrome (sars) and 1 laboratory-contamination accident. here we describe a new phylogenetic analytical method to study the sources and dissemination paths of sars-associated coronavirus (sars-cov) infections in taiwan.200515809907
sars-cov infection was from at least two origins in the taiwan area.severe acute respiratory syndrome (sars) is caused by a new coronavirus. genomic sequence analysis will provide the molecular epidemiology and help to develop vaccines.200515812185
severe acute respiratory syndrome epidemic in taiwan, 2003.in taiwan, since the first case of severe acute respiratory syndrome (sars) was identified on february 25, 2003, a total of 3032 cases of suspected or probable sars were reported prior to july 5, 2003. among these cases, 664 cases were classified as probable sars based on the clinical case definitions and 346 had a positive result for the sars-associated coronavirus (sars-cov). the epidemic in taiwan could be divided into 2 distinct stages. in stage i (late-february to mid-april) patients had tr ...200515843851
adverse effects of ribavirin and outcome in severe acute respiratory syndrome: experience in two medical centers.to assess the effect of ribavirin-induced anemia on the outcome of severe acute respiratory syndrome (sars).200516002945
outbreak of severe acute respiratory syndrome in southern taiwan, 2003.this study describes the epidemiologic features of the severe acute respiratory syndrome (sars) outbreak in southern taiwan in 2003. according to the official files of reported cases of sars from february 21 to june 19, 2003, there were 586 cases in southern taiwan. symptom onset occurred between february 21 and june 19 in reported cases, between march 13 and may 30 in probable cases, and between march 17 and may 23 in polymerase chain reaction (pcr)-positive probable cases. dates of symptom ons ...200516103615
sars-cov genome polymorphism: a bioinformatics study.a dataset of 103 sars-cov isolates (101 human patients and 2 palm civets) was investigated on different aspects of genome polymorphism and isolate classification. the number and the distribution of single nucleotide variations (snvs) and insertions and deletions, with respect to a "profile", were determined and discussed ("profile" being a sequence containing the most represented letter per position). distribution of substitution categories per codon positions, as well as synonymous and non-syno ...200516144519
using an integrated infection control strategy during outbreak control to minimize nosocomial infection of severe acute respiratory syndrome among healthcare workers.healthcare workers (hcws) are at risk of acquiring severe acute respiratory syndrome (sars) while caring for sars patients. personal protective equipment and negative pressure isolation rooms (npirs) have not been completely successful in protecting hcws. we introduced an innovative, integrated infection control strategy involving triaging patients using barriers, zones of risk, and extensive installation of alcohol dispensers for glove-on hand rubbing. this integrated infection control approach ...200616153744
experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a taiwan hospital.to describe the immunological responses and clinical outcome of coronavirus (sars) infected healthcare workers (hcw) who had been administered with convalescent plasma as a treatment.200516183666
modelling sars data using threshold geometric process.during the outbreak of an epidemic disease, for example, the severe acute respiratory syndrome (sars), the number of daily infected cases often exhibit multiple trends: monotone increasing during the growing stage, stationary during the stabilized stage and then decreasing during the declining stage. lam first proposed modelling a monotone trend by a geometric process (gp) [x(i), i=1,2,...] directly such that [a(i-1)x(i), i=1,2,...] forms a renewal process for some ratio a>0 which measures the d ...200616345017
clinical manifestations and inflammatory cytokine responses in patients with severe acute respiratory syndrome.severe acute respiratory syndrome (sars) is a highly transmissible disease with significant morbidity and mortality. death from sars is most often due to rapidly progressive respiratory compromise (acute respiratory distress syndrome, ards) and subsequent multi-organ dysfunction. however, the mechanisms evoking respiratory distress and a fulminant systemic response remain unclear. in order to elucidate the pathogenic mechanisms of sars, we analyzed clinical manifestations and levels of serum cyt ...200516385373
colonization of severe acute respiratory syndrome-associated coronavirus among health-care workers screened by nasopharyngeal swab.to report the efficacy and findings of a large-scale preventive screening program for severe acute respiratory syndrome-associated coronavirus (sars-cov) using amplification of the virus from a nasopharyngeal swab (nps) obtained from the health-care workers (hcws).200616424418
clinical and laboratory features in the early stage of severe acute respiratory syndrome.to characterize the clinical and laboratory features of severe acute respiratory syndrome (sars) in the early stage and to compare them with those of patients initially suspected of having sars who were later determined to have other febrile diseases.200616440123
epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in taiwan in 2003.taiwan experienced a series of outbreaks of nosocomial severe acute respiratory syndrome (sars) infections in 2003. two months after the final outbreak, we recruited 658 employees from the hospital that suffered the first and most severe sars infections to help us investigate epidemiological and genetic factors associated with the sars coronavirus (sars-cov). sars-cov infections were detected by using enzyme immunoassays and confirmed by a combination of western blot assays, neutralizing antibod ...200616455884
acute renal failure in patients with severe acute respiratory syndrome.severe acute respiratory syndrome (sars) is caused by a new coronavirus, and results in respiratory failure. acute renal failure (arf) may also occur and/or complicate the disease course, however, its incidence, causes and impact in sars patients are not known.200516607445
epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory syndrome in a medical center in kaohsiung, taiwan.we conducted an epidemiologic investigation at the beginning of a nosocomial outbreak of severe acute respiratory syndrome (sars) to clarify the dynamics of sars transmission, the magnitude of the sars outbreak, and the impact of the outbreak on the community.200616671027
hospital waste generation during an outbreak of severe acute respiratory syndrome in taiwan.during the sars outbreak in taiwan, the number of ambulatory patients and inpatients treated at one medical center decreased by 40%-70% because of the increasing number of sars patients. at the peak of the epidemic, the amount of hospital infectious waste had increased from a norm of 0.85 kg per patient-day to 2.7 kg per patient-day. however, the hospital was able to return the generation of waste to normal levels within 10 days.200616671038
congruent epidemic models for unstructured and structured populations: analytical reconstruction of a 2003 sars outbreak.both the threat of bioterrorism and the natural emergence of contagious diseases underscore the importance of quantitatively understanding disease transmission in structured human populations. over the last few years, researchers have advanced the mathematical theory of scale-free networks and used such theoretical advancements in pilot epidemic models. scale-free contact networks are particularly interesting in the realm of mathematical epidemiology, primarily because these networks may allow m ...200616904134
the lesson of supplementary treatment with chinese medicine on severe laboratory-confirmed sars patients.chinese medicine (cm) has been used to control infectious diseases for thousands of years. in 2003 outbreaks of severe acute respiratory syndrome (sars) occurred in china, hong kong and taiwan. in view of the possible beneficial effect of cm on sars, we conducted this study to examine whether cm is of any benefit as a supplementary treatment of sars. four severe laboratory-confirmed sars patients received routine western-medicine treatment plus different supplementary treatment: cm a, cm b and c ...200617163582
the psychological effect of severe acute respiratory syndrome on emergency department staff.the severe acute respiratory syndrome (sars) outbreak in 2003 affected 29 countries. the sars outbreak was unique in its rapid transmission and it resulted in heavy stress in first-line healthcare workers, particularly in the emergency department.200717183035
impact of severe acute respiratory syndrome care on the general health status of healthcare workers in taiwan.the impact of the outbreak of severe acute respiratory syndrome (sars) was enormous, but few studies have focused on the infectious and general health status of healthcare workers (hcws) who treated patients with sars.200717230391
challenges faced by hospital healthcare workers in using a syndrome-based surveillance system during the 2003 outbreak of severe acute respiratory syndrome in taiwan.because the severe acute respiratory syndrome (sars) outbreak in taiwan in 2003 was worsened by hospital infections, we analyzed 229 questionnaires (84.8% of 270 sent) completed by surveyed healthcare workers who cared for patients with sars in 3 types of hospitals, to identify surveillance problems. atypical clinical presentation was the most often reported problem, regardless of hospital type, which strongly indicates that more timely syndromic surveillance was needed.200717326030
positive rate of serum sars-cov immunoglobulin g antibody among healthcare workers.we evaluated the positive rate for severe acute respiratory syndrome (sars) -cov igg antibody among taiwanese healthcare workers (hcws). a retrospective cohort research was performed in 2 teaching hospitals and 2 non-teaching hospitals. sars-cov igg antibodies were checked and a structured questionnaire was prepared. a total of 2512 sets of questionnaires was distributed with a return rate of 87.5% (2197 sets). 882 of the respondents had contact with sars patients. among 2197 subjects studied, a ...200717366033
theoretically estimated risk of severe acute respiratory syndrome transmission through blood transfusion during an epidemic in shenzhen, guangdong, china in 2003.severe acute respiratory syndrome (sars) is a newly recognized infectious disease that caused an outbreak in south china in 2003. the cause of sars was identified as a novel coronavirus (cov). the existence of asymptomatic seroconvertors and the detection of the sars-cov rna in plasma during the course of infection all suggest that sars could, as least theoretically, be transmitted by transfusion. an estimate of the risk of sars transmission through blood transfusion will contribute to decisions ...200718036985
seroprevalence of sars coronavirus among residents near a hospital with a nosocomial outbreak.an epidemic of severe acute respiratory syndrome (sars) occurred in taiwan from april to july 2003. a nosocomial outbreak of sars occurred at kaohsiung chang gung memorial hospital (cgmh) in may 2003. the purpose of our study was to survey the prevalence of the sars coronavirus (cov) in a community adjacent to kaohsiung cgmh and collect demographic data, including basic information about health status, household, and possible risk factors for sars-cov infection.200818971158
candidate genes associated with susceptibility for sars-coronavirus.assuming that no human had any previously acquired immunoprotection against severe acute respiratory syndrome coronavirus (sars-cov) during the 2003 sars outbreak, the biological bases for possible difference in individual susceptibility are intriguing. however, this issue has never been fully elucidated. based on the premise that sars patients belonging to a given genotype group having a significantly higher sars infection rate than others would imply that genotype group being more susceptible, ...201019590927
human-leukocyte antigen class i cw 1502 and class ii dr 0301 genotypes are associated with resistance to severe acute respiratory syndrome (sars) infection.one-hundred and thirty confirmed cases of severe acute respiratory syndrome (sars) were recruited to evaluate their anti-sars-coronavirus (cov) antibody status and human leukocyte antigen (hla) types in september 2006, 3 y after the sars outbreaks in taiwan. western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. a case-control study of the association of hla with sars revealed that the hla-cw1502 and dr0301 alleles conferred resistance against ...201121958371
how change of public transportation usage reveals fear of the sars virus in a city.the outbreaks of the severe acute respiratory syndrome (sars) epidemic in 2003 resulted in unprecedented impacts on people's daily life. one of the most significant impacts to people is the fear of contacting the sars virus while engaging daily routine activity. here we use data from daily underground ridership in taipei city and daily reported new sars cases in taiwan to model the dynamics of the public fear of the sars virus during the wax and wane of the sars period. we found that for each re ...201424647278
comparative epidemiology of human infections with middle east respiratory syndrome and severe acute respiratory syndrome coronaviruses among healthcare personnel.the largest nosocomial outbreak of middle east respiratory syndrome (mers) occurred in south korea in 2015. health care personnel (hcp) are at high risk of acquiring mers-coronavirus (mers-cov) infections, similar to the severe acute respiratory syndrome (sars)-coronavirus (sars-cov) infections first identified in 2003. this study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global mers cases and 98 sars cases in taiwan associated wi ...201626930074
detection of the severe acute respiratory syndrome-related coronavirus and alphacoronavirus in the bat population of taiwan.bats have been demonstrated to be natural reservoirs of severe acute respiratory syndrome coronavirus (sars cov) and middle east respiratory syndrome (mers) cov. faecal samples from 248 individuals of 20 bat species were tested for partial rna-dependent rna polymerase gene of cov and 57 faecal samples from eight bat species were tested positive. the highest detection rate of 44% for scotophilus kuhlii, followed by 30% for rhinolophus monoceros. significantly higher detection rates of coronaviral ...201627178103
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