experimental onchocerciasis in chimpanzees: cellular responses and antigen recognition after immunization and challenge with onchocerca volvulus infective third-stage larvae. | immunization of chimpanzees with radiation-attenuated infective 3rd-stage larvae (l3) of onchocerca volvulus did not induce strong protective immunity against a subsequent challenge infection; only 1 out of 4 immunized animals remained non-patent (i.e. microfilariae-negative) after challenge, and may have been protected. however, during immunization and before challenge, a broad range of adult o. volvulus-derived antigens (ovag) and also uterus-derived ovag were recognized by circulating antibod ... | 1993 | 8356001 |