Publications

one-step nested rt-pcr for covid-19 detection: a flexible, locally developed test for sars-cov2 nucleic acid detection.	due to the coronavirus pandemic, identifying the infected individuals has become key to limiting its spread. virus nucleic acid real-time rt-pcr testing has become the current standard diagnostic method but high demand could lead to shortages. therefore, we propose a detection strategy using a one-step nested rt-pcr.	2020	32794453
a palindromic rna sequence as a common breakpoint contributor to copy-choice recombination in sars-cov-2.	much remains unknown concerning the origin of the novel pandemic coronavirus that has raged across the globe since emerging in wuhan of hubei province, near the center of the people's republic of china, in december of 2019. all current members of the family coronaviridae have arisen by a combination of incremental adaptive mutations, against the backdrop of many recombinational events throughout the past, rendering each a unique mosaic of rna sequences from diverse sources. the consensus among v ...	2020	32737584
proteolytic cleavage of the sars-cov-2 spike protein and the role of the novel s1/s2 site.	severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the causative agent of coronavirus disease 19 (covid-19) has rapidly spread from an initial outbreak in wuhan, china in december 2019 to the rest of the world within a few months. on march 11th 2020, the rapidly evolving covid-19 situation was characterized as a pandemic by the who. much attention has been drawn to the origin of sars-cov-2, a virus which is related to the lineage b betacoronavirus sars-cov and sars-related coronavirus ...	2020	32714113
sars-cov-2 envelope and membrane proteins: structural differences linked to virus characteristics?	the coronavirus disease 2019 (covid-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (sars-cov-2). genomic analyses have revealed that sars-cov-2 is related to pangolin and bat coronaviruses. in this report, a structural comparison between the sars-cov-2 envelope and membrane proteins from different human isolates with homologous proteins from closely related viruses is described. the analyses here reported show the high structural similarity of envelope and memb ...	2020	32596311
exploring the genomic and proteomic variations of sars-cov-2 spike glycoprotein: a computational biology approach.	the newly identified sars-cov-2 has now been reported from around 185 countries with more than a million confirmed human cases including more than 120,000 deaths. the genomes of sars-cov-2 strains isolated from different parts of the world are now available and the unique features of constituent genes and proteins need to be explored to understand the biology of the virus. spike glycoprotein is one of the major targets to be explored because of its role during the entry of coronaviruses into hos ...	2020	32502733