Publications

covdb: a comprehensive database for comparative analysis of coronavirus genes and genomes.	the recent sars epidemic has boosted interest in the discovery of novel human and animal coronaviruses. by july 2007, more than 3000 coronavirus sequence records, including 264 complete genomes, are available in genbank. the number of coronavirus species with complete genomes available has increased from 9 in 2003 to 25 in 2007, of which six, including coronavirus hku1, bat sars coronavirus, group 1 bat coronavirus hku2, groups 2c and 2d coronaviruses, were sequenced by our laboratory. to overco ...	2008	17913743
complete genome sequence of bat coronavirus hku2 from chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome.	apart from bat-sars-cov, we have identified a novel group 1 coronavirus, bat-cov hku2, in rhinolophus sinicus (chinese horseshoe bats). since it has been suggested that the receptor-binding motif (rbm) of sars-cov may have been acquired from a group 1 coronavirus, we conducted a surveillance study and identified bat-sars-cov and bat-cov hku2 in 8.7% and 7.5% respectively of r. sinicus in hong kong and guangdong. complete genome sequencing of four strains of bat-cov hku2 revealed the smallest cor ...	2007	17617433
comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features.	twelve complete genomes of three novel coronaviruses-bat coronavirus hku4 (bat-cov hku4), bat-cov hku5 (putative group 2c), and bat-cov hku9 (putative group 2d)-were sequenced. comparative genome analysis showed that the various open reading frames (orfs) of the genomes of the three coronaviruses had significantly higher amino acid identities to those of other group 2 coronaviruses than group 1 and 3 coronaviruses. phylogenetic trees constructed using chymotrypsin-like protease, rna-dependent rn ...	2007	17121802
prevalence and genetic diversity of coronaviruses in bats from china.	coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. the interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. the outbreak of severe acute respiratory syndrome (sars) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals ...	2006	16840328
identification of a novel coronavirus in bats.	exotic wildlife can act as reservoirs of diseases that are endemic in the area or can be the source of new emerging diseases through interspecies transmission. the recent emergence of severe acute respiratory syndrome-associated coronavirus (sars-cov) highlights the importance of virus surveillance in wild animals. here, we report the identification of a novel bat coronavirus through surveillance of coronaviruses in wildlife. analyses of the rna sequence from the orf1b and s-gene regions indicat ...	0	15681402