Publications

sars-cov-2: zoonotic origin of pandemic coronavirus.	a novel disease, of unknown origin, causing a deadly pneumonia of human patients was reported in december 2019 in wuhan, hubei province of china. later called coronavirus disease (covid-19), it rapidly spread across china and worldwide. intensive research revealed that the etiological agent of the global covid-19 pandemic was a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the sars-cov-2 genome contains typical coronavirus genes but the receptor binding do ...	2020	32985202
a novel bat coronavirus closely related to sars-cov-2 contains natural insertions at the s1/s2 cleavage site of the spike protein.		2020	33022232
a systematic review of etiology, epidemiology, clinical manifestations, image findings, and medication of 2019 corona virus disease-19 in wuhan, china.	unknown origin pneumonia has been furiously spreading since the late of december 2019, subsequently spread to approximately all provinces and areas in china and many countries, which was announced as a public health emergency of international concern by world health organization (who). the studies on 2019 corona virus disease-19 (covid-19) conducted from various fields around the world. herein, the objective of the present study is to summarize the etiology, epidemiology, clinical manifestations ...	2020	33080715
sequence analysis and structure prediction of sars-cov-2 accessory proteins 9b and orf14: evolutionary analysis indicates close relatedness to bat coronavirus.	severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has a single-stranded rna genome that encodes 14 open reading frames (orfs), eight of which encode accessory proteins that allow the virus to infect the host and promote virulence. the genome expresses around 29 structural and nonstructural protein products. the accessory proteins of sars-cov-2 are not essential for virus replication but do affect viral release, stability, and pathogenesis and finally contribute to virulence. this pape ...	2020	33102591
covid-19 neutralizing antibodies predict disease severity and survival.	covid-19 exhibits variable symptom severity ranging from asymptomatic to life-threatening, yet the relationship between severity and the humoral immune response is poorly understood. we examined antibody responses in 113 covid-19 patients and found that severe cases resulting in intubation or death exhibited increased inflammatory markers, lymphopenia, and high anti-rbd antibody levels. while anti-rbd igg levels generally correlated with neutralization titer, quantitation of neutralization poten ...	2020	33106822