Publications

[antimicrobial and antispirochetal activity of pharmachem's tylosin].	studies are the following preparations, produced by "pharmachim": tylosine-base (tylosine-50), tylosine tartarate (tylosine pulvis) and tylosine phosphate (substance and granules) and their analogues: tylosine-base (tylan-50), tylosine tartarate (tylan soluble) and tylosine phosphate (tylan af 99), produced by the "elanco" company. the biological activity of the preparation was determined by means of the microbiological method of diffusion in agar. in the case of all experimental treatments, the ...	1978	751322
tick borne relapsing fever imported into the united kingdom.	a case of tick borne relapsing fever contracted in cyprus and imported into england is reported. this is the first report of the diagnosis being established by finding the organism in the bone marrow.	1985	4045802
lyme disease in a hampshire child--medical curiosity or beginning of an epidemic?		1986	3087517
borrelia burgdorferi in urban parks.		1991	1676804
evidence for the transmission of the lyme disease spirochaete to sheep in cumbria.		1994	7831744
should we routinely screen for lyme disease in patients with asymmetrical hearing loss?	asymmetrical sensorineural hearing loss is usually investigated thoroughly but a diagnosis is often elusive. it is important to identify any treatable causes. lyme disease is a tick-borne infection caused by the spirochaete borrelia burgdorferi, which has been shown to cause asymmetrical sensorineural hearing loss, and has been successfully treated. its incidence varies regionally; it occurs where there is a suitable environment for the tick and its animal hosts. we conducted a prospective study ...	1994	7841889
evidence for lyme disease in urban park workers: a potential new health hazard for city inhabitants.	in the uk, cases of lyme disease have only been reported from rural areas. recently, however, ixodes ticks infected with borrelia burgdorferi have been found in london parks. to determine whether this constituted a health hazard, we questioned 44 workers from richmond and bushey parks to assess their exposure to tick bites and whether they had a clinical history of lyme disease. their serum was subsequently investigated for antibodies to two different preparations of borrelia burgdorferi (whole ...	1994	8162475
borrelia burgdorferi infection in uk horses.	antibody levels (igg and igm) to borrelia burgdorferi were measured in the sera and synovial fluids of uk horses. western blotting against b. burgdorferi was also used on samples from seropositive horses. a low incidence of seropositivity was shown in horses from most parts of the uk. this increased in areas that have a high incidence of human and canine borreliosis (norfolk and south coast). leptospira infections of horses did not cause cross reactions in the b. burgdorferi elisa. most horses d ...	1994	8542836
the value of serological testing for lyme disease in the uk.	although the prevalence of lyme disease (ld) in the uk is low, patients with clinical presentations compatible with the condition are common. arthritis often complicates ld in north america, however it is a very rare complication of the condition in the uk. many patients seen at st george's hospital, london have visited endemic areas for ld within the uk, europe and north america. to determine the value of serological testing for ld in the uk, we prospectively studied 120 patients seen at this h ...	1995	7704458
distribution of borrelia burgdorferi s.l. spirochaete dna in british ticks (argasidae and ixodidae) since the 19th century, assessed by pcr.	the distribution of borrelia burgdorferi sensu lato, the lyme borreliosis agent, was surveyed in british ticks in the collection of the natural history museum, london. alcohol-preserved specimens of eight species of ticks known to attack humans were studied: ixodes ricinus, i. hexagonus, i. uriae, i. trianguliceps, dermacentor reticulatus, haemaphysalis punctata, rhipicephalus sanguineus and argas vespertilionis. the sample comprised all life stages and originated from a wide range of host speci ...	1998	9513944
differential transmission of the genospecies of borrelia burgdorferi sensu lato by game birds and small rodents in england.	the genetic diversity of borrelia burgdorferi sensu lato was assessed in a focus of lyme borreliosis in southern britain dominated by game birds. ticks, rodents, and pheasants were analyzed for spirochete infections by pcr-targeting the 23s-5s rrna genes, followed by genotyping by the reverse line blot method. in questing ixodes ricinus ticks, three genospecies of b. burgdorferi sensu lato were detected, with the highest prevalences found for borrelia garinii and borrelia valaisiana. b. burgdorf ...	1998	9546150
lyme disease surveillance in england and wales, 1986 1998.	improved surveillance indicates that lyme borreliosis, an emerging zoonosis in the united kingdom, has increased from 0.06/100,000 during 1986-1992 to 0.32/100,000 since 1996. case reports peaked in the third quarter of each year. several high-incidence localities were identified. erythema migrans was reported in 41% of patients; arthritis in 4%; musculoskeletal symptoms in 18%; and neuroborreliosis in 15%.	2000	10905978
tick bite and lyme borreliosis risk at a recreational site in england.	the risk of tick bite and lyme borreliosis in a forested area in england with public access was studied over a two-year period. tick infestation levels were high with more than 1000 members of the public reporting for tick removal at a local clinic. most of the attached ticks were nymphs (82%) and distinct differences in anatomical sites of attachment were observed in children and adults. children sustained nymphal bites to the head, neck and axilla region much more frequently than adults (48 vs ...	2000	11078122
4th meeting of the eu research network eurome: from the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, london, uk, 9 march 2004.	rheumatoid arthritis (ra) is a common human disease with a prevalence of about 1% in most parts of the world. at the time of symptom onset it is difficult to predict the severity of subsequent disease course. after 2 years joint erosions are seen in most patients, and most patients become clinically disabled within 20 years. a recent meeting at the kennedy institute of rheumatology (imperial college, london) brought together representatives from several european centres of excellence, to discuss ...	2004	15225359
neuroborreliosis in the south west of england.	although lyme borreliosis is increasingly diagnosed in the united kingdom, few systematic studies have been performed there. uk data suggest that the commonest complications are neurological, but inadequate information exists about their nature and the incidence of late neuroborreliosis. local data are necessary because clinical presentations may show geographical variation. this study aimed to provide data on clinical manifestations in an area of south west england and to estimate treatment del ...	2008	18325130
lyme disease: an unusual case of peripheral nerve palsy.	lyme disease is a vector-borne multisystem inflammatory disease caused by the spirochete borrelia burgdorferi sensu lato. this disease is frequently seen in north america and to a lesser degree in europe. however, its presence in england is uncommon and we present a case in which the patient developed a palsy of the common peroneal nerve.	2010	20436011
prevalence of borrelia infection in ticks from wildlife in south-west england.		2010	21262733
host migration impacts on the phylogeography of lyme borreliosis spirochaete species in europe.	the geographic patterns of transmission opportunities of vector-borne zoonoses are determined by a complex interplay between the migration patterns of the host and the vector. here we examine the impact of host migration on the spread of a tick-borne zoonotic disease, using lyme borreliosis (lb) spirochaetal species in europe. we demonstrate that the migration of the lb species is dependent on and limited by the migration of their respective hosts. we note that populations of borrelia spp. assoc ...	2011	20722696