| intracystic papillary carcinoma of the breast: an in situ or invasive tumor? results of immunohistochemical analysis and clinical follow-up. | intracystic papillary carcinoma (ipc) is regarded as an intraductal neoplasm, but recent evidence suggests that it could be invasive, as it often lacks myoepithelial lining. we evaluated myoepithelial cells and collagen iv, a basement membrane component, in 40 ipcs from 39 (35 female and 4 male) patients and assessed their clinical management and follow-up. the mean patient age at diagnosis was 68 years, and the mean tumor size was 1.8 cm. thirteen cases were pure ipc, 8 cases were ipc with or w ... | 2011 | 21084964 |
| syringe exchange programs --- united states, 2008. | persons who inject drugs should use a new, sterile needle and syringe for each injection. syringe exchange programs (seps) provide free sterile syringes and collect used syringes from injection-drug users (idus) to reduce transmission of bloodborne pathogens, including human immunodeficiency virus (hiv), hepatitis b virus, and hepatitis c virus (hcv). as of march 2009, a total of 184 seps were known to be operating in 36 states, the district of columbia (dc), and puerto rico (north american syri ... | 2010 | 21085091 |
| knowledge, attitudes, and practices of us travelers to asia regarding seasonal influenza and h5n1 avian influenza prevention measures. | international travel is a potential risk factor for the spread of influenza. in the united states, approximately 5%-20% of the population develops an influenza-like illness annually. the purpose of this study was to describe the knowledge, attitude, and practices of us travelers to asia regarding seasonal influenza and h5n1 avian influenza (ai) prevention measures. | 2010 | 21050316 |
| phylogeography of the spring and fall waves of the h1n1/09 pandemic influenza virus in the united states. | spatial variation in the epidemiological patterns of successive waves of pandemic influenza virus in humans has been documented throughout the 20th century but never understood at a molecular level. however, the unprecedented intensity of sampling and whole-genome sequencing of the h1n1/09 pandemic virus now makes such an approach possible. to determine whether the spring and fall waves of the h1n1/09 influenza pandemic were associated with different epidemiological patterns, we undertook a larg ... | 2010 | 21068250 |
| somos: evaluation of an hiv prevention intervention for latino gay men. | latino gay men face multiple barriers to human immunodeficiency virus (hiv) prevention, in particular a lack of intervention programs that integrate prevention messages with cultural norms and address issues of social marginalization from multiple communities (gay community and latino community), homophobia and racism. in order to address these specific issues, a multilayered hiv intervention was designed to incorporate and integrate psychosocial and community factors through multiple session gr ... | 2010 | 21059799 |
| hospitalizations for tuberculosis in new york city: how many could be avoided? | to determine which factors were associated with hospitalization for tuberculosis (tb) in new york city (nyc), united states, and to estimate the proportion of potentially avoidable admissions. | 2010 | 21144247 |
| achieving international targets for tuberculosis treatment success among hiv-positive patients in new york city. | to review outcomes of human immunodeficiency virus (hiv) positive tuberculosis (tb) patients in new york city (nyc) to determine if the world health organization treatment success target of 85% was met in a setting with ready access to treatment for hiv and tb. | 2010 | 21144248 |
| characterization of interleukin-17-producing regulatory t cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. | interleukin (il)-17-producing cd4(+) helper t cells (th17) mediate mucosal immunity and are involved in the pathogenesis of inflammatory bowel disease (ibd). they are believed to arise from the same precursor population as regulatory t (treg) cells, but little is known about how these t-cell subsets interact under chronic inflammatory conditions. we studied th17 and treg cells isolated from intestinal lamina propria of patients with ibd to investigate their role in pathogenesis. | 2010 | 21147109 |
| workforce training and education gaps in gerontology and geriatrics: what we found in new york state. | this article summarizes data from the 2008 symposium charting the future for new york state workforce training and education in aging: the stakeholder perspective and the 2009 report workforce training and education: the challenge for academic institutions. this research is the outcome of a collaborative state society on aging of new york and new york state office for the aging study on new york state's workforce training and education needs. eight listening sessions were held across new york st ... | 2010 | 21108099 |
| infectious chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. | neutrophilic asthma is thought to be less responsive than eosinophilic asthma to anti-inflammatory therapies including corticosteroids. chlamydia pneumoniae has been implicated in asthma, possibly by induction of interleukin (il-8). we hypothesized that il-8 is increased in the bronchoalveolar lavage (bal) fluid from children with asthma and c. pneumoniae. | 2010 | 21155094 |
| a tribute to seymour steven brody: in memoriam (november 29, 1927 to may 25, 2010). | we honor steve brody, a dear friend and a mentor on what would have been his 83rd birthday (november 29, 2010). steve was a pioneer of chlorophyll structure and function, an outstanding biophysicist, an innovator, an artist and an adventurer, a true renaissance man. we present here first his first-of-a-kind contributions on the primary processes of photosynthesis at the university of illinois at urbana-champaign, and then review his research on the interactions of chlorophyll monolayers and vari ... | 2010 | 21161598 |
| linking emergency preparedness and health care worker vaccination against influenza: a novel approach. | health care workers (hcws) can acquire and transmit influenza to their patients and coworkers, even while asymptomatic. the u.s. healthy people 2010 initiative set a national goal of 60% coverage for hcw influenza vaccination by 2010. yet vaccination rates remain low. in the 2008-2009 influenza season, flushing hospital medical center (fhmc; new york) adopted a "push/pull" point-of-dispensing (pod) vaccination model that was derived from emergency preparedness planning for mass vaccination and/o ... | 2010 | 21090019 |
| peak cardiac power measured noninvasively with a bioreactance technique is a predictor of adverse outcomes in patients with advanced heart failure. | peak oxygen consumption (vo(2) ) during cardiopulmonary exercise testing (cpet) is a powerful predictor of survival, providing an indirect assessment of cardiac output (co). noninvasive indices of co derived from bioreactance methodology would add significantly to peak vo(2) as a means of risk-stratifying patients with heart failure. in this study, 127 patients (53 ± 14 years of age, 66% male) with heart failure and an average ejection fraction of 31% ± 15% underwent symptom-limited cpet using a ... | 2010 | 21091609 |
| subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing ttf-1, napsin a, p63, and ck5/6. | the availability of targeted therapies has created a need for precise subtyping of non-small cell lung carcinomas (nsclcs). the aim of this study was to assess the utility of immunohistochemical markers in subtyping poorly differentiated nsclc and to compare the results of immunohistochemical staining on biopsies with the corresponding resections. thirty-nine cases of nsclc that could not be further classified on biopsy and had subsequent resection specimens were identified. classification of th ... | 2011 | 21164283 |
| long-term posttraumatic stress symptoms among 3,271 civilian survivors of the september 11, 2001, terrorist attacks on the world trade center. | although the september 11, 2001, terrorist attacks were the largest human-made disaster in us history, there is little extant research documenting the attacks' consequences among those most directly affected, that is, persons who were in the world trade center towers. data from a cross-sectional survey conducted 2-3 years after the attacks ascertained the prevalence of long-term, disaster-related posttraumatic stress symptoms and probable posttraumatic stress disorder (ptsd) in 3,271 civilians w ... | 2010 | 21190987 |
| simultaneous identification of mycobacterial isolates to the species level and determination of tuberculosis drug resistance by pcr followed by electrospray ionization mass spectrometry. | mycobacterium tuberculosis that is resistant to both isoniazid (inh) and rifampin (rif) is spreading. it has become a public health problem in part because the standard culture methods used to determine the appropriate treatment regimen for patients often take months following the presumptive diagnosis of tuberculosis. furthermore, the misidentification of nontuberculosis mycobacteria (ntm) in patients presumably suffering from tuberculosis results in additional human and health care costs. the ... | 2010 | 21191060 |
| barriers to mask wearing for influenza-like illnesses among urban hispanic households. | to identify barriers to mask wearing and to examine the factors associated with the willingness to wear masks among households. | 2010 | 21198810 |
| infectious syphilis among adolescent and young adult men: implications for human immunodeficiency virus transmission and public health interventions. | background:: in 2008, an increase in syphilis among young black men was noted in new york city (nyc), miami-fort lauderdale, and philadelphia. to explore this trend, we examined infectious syphilis cases from 2000 to 2008 among adolescent and young adult men in these areas. methods:: descriptive analysis of male infectious syphilis cases reported to public health authorities in nyc, fl, and philadelphia. results:: from 2000 to 2008, infectious syphilis cases among males increased in nyc (107-102 ... | 2010 | 21150816 |
| vitamin d status and antibody levels to common viruses in pediatric-onset multiple sclerosis. | the relative contribution and interaction of risk factors for multiple sclerosis (ms) have not been evaluated. objectives: to determine whether vitamin d status is associated with antibody levels to common viruses in pediatric-onset ms or clinically isolated syndrome (cis) patients and controls. | 2011 | 21212086 |
| sexual partner characteristics, serodiscordant/serostatus unknown unprotected anal intercourse and disclosure among human immunodeficiency virus-infected and uninfected black men who have sex with men in new york city. | : black men who have sex with men (msm) are disproportionately infected with human immunodeficiency virus (hiv) in the united states. this study describes sexual partner characteristics and disclosure of hiv serostatus and evaluates factors associated with sexual risk behaviors during last sex among black msm. | 2011 | 21217419 |
| mass commuting and influenza vaccination prevalence in new york city: protection in a mixing environment. | assess influenza vaccination among commuters using mass transit in new york city (nyc). | 2010 | 21218159 |
| estimation of the incubation period of influenza a (h1n1-2009) among imported cases: addressing censoring using outbreak data at the origin of importation. | empirical estimates of the incubation period of influenza a (h1n1-2009) have been limited. we estimated the incubation period among confirmed imported cases who traveled to japan from hawaii during the early phase of the 2009 pandemic (n=72). we addressed censoring and employed an infection-age structured argument to explicitly model the daily frequency of illness onset after departure. we assumed uniform and exponential distributions for the frequency of exposure in hawaii, and the hazard rate ... | 2010 | 21168422 |
| barriers and facilitators to implementing primary stroke center policy in the united states: results from 4 case study states. | we identified barriers and facilitators to the state-level implementation of primary stroke center (psc) policies, which encourage the certification or designation of specialized stroke treatment facilities and may address concerns such as transportation bypass, telemedicine, and treatment protocols. | 2011 | 21233430 |
| rabid foxes, rabid raccoons, and the odds of a human bite exposure, new york state, 1999-2007. | anecdotal evidence suggests that rabid foxes are more likely to attack humans than are other rabid terrestrial animals. to examine this issue, we analyzed rabies surveillance data (1999-2007) maintained by the new york state department of health. compared to rabid raccoons (procyon lotor), foxes infected with raccoon variant rabies were more likely to bite during a human exposure incident (p<0.01). additionally, rabid gray foxes (urocyon cinereoargenteus) were significantly more likely to bite a ... | 2011 | 21270014 |
| the first national pain medicine summit--final summary report. | pain is ubiquitous. at some point in time it affects everyone. for many millions pain becomes chronic, a scourge that impacts every facet of life-work, hobbies, family relations, social fabric, finances, happiness, mood, and even the very essence of identity. according to the national institutes of health (nih), pain is one of our most important national public health problems, a silent epidemic. in 1998, nih reported that the annual amount spent on health care, compensation, and litigation rela ... | 2010 | 21199301 |
| occurrence of bisphenol a in indoor dust from two locations in the eastern united states and implications for human exposures. | bisphenol a (bpa) is used in the production of polycarbonate plastics and epoxy resins, which are used in many consumer products. sources of human exposures to bpa include packaged and canned food products, indoor air, and dust ingestion. information on the relative contributions of the pathways to bpa exposures is limited. in this study, we measured concentrations bpa in indoor dust collected from two locations in the eastern united states and evaluated the contribution of dust to total bpa exp ... | 2011 | 21221962 |
| lichen sclerosus: epidemiological distribution in an equal access health care system. | the incidence and demographics of lichen sclerosus range from 1/300 (0.3%) to 1/1,000 individuals (0.1%). we analyzed the incidence of lichen sclerosus in an equal access health care system, hypothesizing that it is more common in older white males. | 2010 | 21168879 |
| text message reminders to promote human papillomavirus vaccination. | to implement and evaluate text message reminders for the second (hpv2) and third (hpv3) vaccine doses. | 2011 | 21300094 |
| individual- and neighborhood-level characteristics associated with support of in-pharmacy vaccination among esap-registered pharmacies: pharmacists' role in reducing racial/ethnic disparities in influenza vaccinations in new york city. | new york state (nys) passed legislation authorizing pharmacists to administer immunizations in 2008. racial/socioeconomic disparities persist in vaccination rates and vaccine-preventable diseases such as influenza. many nys pharmacies participate in the expanded syringe access program (esap), which allows provision of non-prescription syringes to help prevent transmission of hiv, and are uniquely positioned to offer vaccination services to low-income communities. to understand individual and nei ... | 2011 | 21279450 |
| evaluation of hiv incidence surveillance in new york city, 2006. | in 2005, the new york city (nyc) department of health and mental hygiene implemented a standardized human immunodeficiency virus (hiv) incidence surveillance protocol based on the serologic testing algorithm for recent hiv seroconversion deployed nationwide by the centers for disease control and prevention (cdc). we evaluated four key attributes of nyc's hiv incidence surveillance system-simplicity, data quality, timeliness, and acceptability--using cdc's guidelines for surveillance system evalu ... | 2011 | 21337929 |
| closing schools in response to the 2009 pandemic influenza a h1n1 virus in new york city: economic impact on households. | understanding the effectiveness of a school closure in limiting social interaction and the economic impact of school closure on households is critical when developing guidelines to prevent spread of pandemic influenza. a new york city survey conducted in june 2009 in 554 households affected by the 2009 pandemic influenza h1n1-related school closures showed that, during closure, 30% of students visited at least 1 locale outside their homes. if all the adults in the home were employed, an ill chil ... | 2011 | 21342890 |
| hiv-infected hospitalized patients with 2009 pandemic influenza a (ph1n1)--united states, spring and summer 2009. | we describe the clinical findings of hiv-infected patients hospitalized with 2009 pandemic influenza a (ph1n1). data were derived from 3 separate case series in the united states. among 911 adults hospitalized with ph1n1 influenza, 31 (3.4%) were hiv infected compared with an hiv prevalence of 0.45% in the general us adult population. hiv-infected influenza patients experienced similar rates of intensive care unit admission (29% vs 34%) and death (13% vs 13%) compared with non-hiv-infected patie ... | 2011 | 21342893 |
| epidemiology of 2009 pandemic influenza a (h1n1) deaths in the united states, april-july 2009. | during the spring of 2009, pandemic influenza a (h1n1) virus (ph1n1) was recognized and rapidly spread worldwide. to describe the geographic distribution and patient characteristics of ph1n1-associated deaths in the united states, the centers for disease control and prevention requested information from health departments on all laboratory-confirmed ph1n1 deaths reported from 17 april through 23 july 2009. data were collected using medical charts, medical examiner reports, and death certificates ... | 2011 | 21342901 |
| public engagement on new york state's plan for allocating ventilators during a pandemic. | | 2011 | 21353914 |
| incident hepatitis c virus infection among us hiv-infected men enrolled in clinical trials. | outbreaks of sexually transmitted hepatitis c virus (hcv) infection have been reported among human immunodeficiency virus (hiv)-infected men who have sex with men in europe, australia, and new york. whether this is occurring across the united states is unknown. | 2011 | 21282184 |
| norman garmezy (1918-2009). | norman garmezy, a pioneer in research on risk and resilience, died in nashville, tennessee, on november 21, 2009, at the age of 91. he was a legendary mentor as well as an eminent scientist in clinical psychology. norm was born on june 18, 1918, in new york city and grew up in the bronx in a jewish neighborhood where educational attainment was highly valued. the scientific study of resilience as conceived by norman garmezy, his peers, and students has transformed the science and practice of mult ... | 2011 | 21299255 |
| sexual behaviors of adolescent emerging and young adult men who have sex with men ages 13-29 in new york city. | hiv infections among young men who have sex with men (ymsm), ages 13-29 in new york city have been steadily increasing over the last decade. | 2011 | 21317586 |
| dental shape match rates in selected and orthodontically treated populations in new york state: a two-dimensional study. | forensically identifying a suspect's dentition from a bitemark in an open population requires the supposition that every person's dental alignment is different. there have been few studies that have tested this claim. four hundred and ten lower anterior dentitions from a selected population and 110 lower anterior dentitions from one that was orthodontically treated were measured using geometric morphometric analysis, allowing comparison of arch shape. dental match rates of 1.46% and 42.7% of ind ... | 2011 | 21361951 |
| perceptions of and willingness to engage in public health precautions to prevent 2009 h1n1 influenza transmission. | recommendations about precautionary behaviors are a key part of public health responses to infectious disease threats such as the 2009 h1n1 pandemic. individuals' interpretation of recommendations, willingness to comply, and factors predicting willingness were examined. | 2011 | 21385436 |
| health care workers and swine flu. | | 2011 | 21402821 |
| protecting the public from h1n1 through points of dispensing (pods). | in fall 2009, the new york city department of health and mental hygiene (dohmh) operated 58 points of dispensing (pods) over 5 weekends to provide influenza a (h1n1) 2009 monovalent vaccination to new yorkers. up to 7 sites were opened each day across the 5 boroughs, with almost 50,000 new yorkers being vaccinated. the policies and protocols used were based on those developed for new york city's pod plan, the cornerstone of the city's mass prophylaxis planning. before the h1n1 experience, nyc ha ... | 2011 | 21361797 |
| human papillomavirus vaccine uptake and barriers: association with perceived risk, actual risk and race/ethnicity among female students at a new york state university, 2010. | understanding human papillomavirus (hpv) vaccine uptake patterns is critical to improve vaccination levels. approximately half (56%) of female undergraduate students surveyed at a large public university reported hpv vaccine series initiation, with 79% of initiators completing the three dose series. predictors of series initiation included having a conversation with a health-care provider about the vaccine, reporting a history of sexual intercourse and receipt of the meningitis vaccine. compared ... | 2011 | 21376797 |
| women's knowledge and awareness of gynecologic cancer: a multisite qualitative study in the united states. | u.s. women's awareness and knowledge of gynecologic cancer have not been well studied, with the exception of cervical cancer screening and risk factors. | 2011 | 21413897 |
| shorter anogenital distance predicts poorer semen quality in young men in rochester, new york. | in male rodents, anogenital distance (agd) provides a sensitive and continuous correlate of androgen exposure in the intrauterine environment and predicts later reproductive success. some endocrine-disrupting chemicals can alter male reproductive tract development, including shortening agd, in both rodents and humans. whether agd is related to semen quality in human is unknown. | 2011 | 21377950 |
| influenza vaccination and its impact on hospitalization events in nursing homes. | objectives: to examine trends of influenza vaccination in nursing homes before and after public reporting (objective-1), and to assess the effect of influenza vaccinations on hospitalization events (objective-2). research design: nursing home compare (nhc) database was used to obtain influenza vaccination rates during the 2005-2006, 2006-2007, and 2007-2008 flu seasons (objective-1). the 2005-2007 minimum data set for new york state (nys) was obtained and linked with the nhc data (objective-2). ... | 2010 | 21450172 |
| hiv transmitted from a living organ donor--new york city, 2009. | routine screening of organ donors for human immunodeficiency virus (hiv) infection has made transmission of hiv through organ transplantation rare in the united states. however, despite routine screening, transmission of hiv can be an uncommon complication of organ transplantation and is a public health concern. in 2010, the new york city (nyc) department of health and mental hygiene (nyc dohmh) was notified of a potential transplant-related hiv infection. this report summarizes the results of t ... | 2011 | 21412210 |
| comparative assessment of human exposure to phthalate esters from house dust in china and the united states. | because of volatilization and leaching from their application in consumer and personal care products, phthalate esters are ubiquitous contaminants in the indoor environment. in this study, we measured concentrations and profiles of 9 phthalate esters in indoor dust samples collected from six cities in china (n = 75). for comparison, we also analyzed samples collected from albany, new york, usa (n = 33). the results indicated that concentrations, except for dicyclohexyl phthalate (dchp) and bis(2 ... | 2011 | 21434628 |
| henry jacob bigelow (1818-1890): his contributions to anatomy and surgery. | there have been many advances in the medical world over time that have greatly contributed to ameliorating and prolonging human life. the employment of surgical anesthesia is arguably one of the greatest medical discoveries of all time, and has immensely broadened our ability to treat the ill. while dr. henry jacob bigelow (1818-1890) was not the inventor of anesthesia, he was the first to publish and advocate its use in the 19th century (bigelow and bigelow [1894] a memoir of henry jacob bigelo ... | 2011 | 21412854 |
| frequency and clinicopathologic correlates of kras amplification in non-small cell lung carcinoma. | background: characterization of the non-small cell lung cancer (nsclc) genome has suggested that kras amplification is one of the commonest molecular abnormalities in nsclc. however, the prevalence and clinicopathologic significance of kras amplification, and its relationship with kras activating mutations have not been well-defined. the purpose of this study was to establish the prevalence of kras amplification in two separate, large nsclc cohorts, to define the clinicopathologic features of kr ... | 2011 | 21477882 |
| factors associated with unprotected exposure to 2009 h1n1 influenza a among healthcare workers during the first wave of the pandemic. | protecting healthcare workers (hcws) from occupational exposure to 2009 h1n1 influenza was a challenge. during the first wave of the pandemic, many hcws reported that they had been exposed to 2009 h1n1 when they were not using respiratory personal protective equipment. unprotected exposures tended to be more frequent among hcws caring for patients with atypical clinical presentations. | 2011 | 21460517 |
| c-reactive protein, interleukin-6, and posttraumatic stress disorder symptomology in urban police officers. | our aim was to examine the relationship between the level of the inflammatory markers, c-reactive protein (crp) and interleukin-6 (il-6), and posttraumatic stress disorder (ptsd) symptomology in a random sample of 115 police officers. crp was measured in citrated plasma using a particle enhanced immunonepholometric assay and il-6 was measured in serum with a solid-phase quantitative sandwich elisa. the presence of high ptsd symptomology was defined as having an impact of event scale score (ies) ... | 2011 | 21493089 |
| limb venous compliance responses to lower body negative pressure in humans with high blood pressure. | this study tested the hypothesis that limb venous responses to baroreceptor unloading are altered in individuals with high blood pressure (hbp) compared with normotensive (nt) controls. calf venous compliance was assessed in 20 subjects with prehypertension and stage-1 hypertension (mean arterial pressure, map: 104±1 mm hg) and 13 nt controls (map: 86±2 mm hg) at baseline and during lower body negative pressure (lbnp), using venous occlusion plethysmography. baroreflex sensitivity (brs) was meas ... | 2011 | 21471995 |
| intervention to influence behaviors linked to risk of chronic diseases: a multisite randomized controlled trial with african-american hiv-serodiscordant heterosexual couples. | background: the high morbidity and mortality in african americans associated with behavior-linked chronic diseases are well documented. methods: we tested the efficacy of an intervention to increase multiple health-related behaviors in african americans. in a multisite cluster-randomized controlled trial, groups of african american human immunodeficiency virus (hiv)-serodiscordant heterosexual couples in atlanta (georgia), los angeles (california), new york (new york), and philadelphia (pennsylv ... | 2011 | 21518939 |
| elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve. | to investigate the association between elevated body mass index (bmi) and ovarian reserve. | 2011 | 21529798 |
| use of low-dose steroids in decreasing cytokine release during bilateral total knee replacement. | interleukin 6 (il-6), a marker of inflammation, is one of the major cytokines released during joint replacement. in the orthopedic patient population, high levels have been linked to many adverse effects including acute respiratory distress syndrome, postoperative mental status changes, and fever. we looked to assess the efficacy of low-dose steroids on the postinflammatory response as measured by il-6 in patients undergoing bilateral total knee replacement (btkr). the role of steroids has never ... | 2011 | 21455087 |
| random anti-müllerian hormone (amh) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels. | to investigate the utility of random anti-müllerian hormone (amh) in assessing ovarian response among women with diminished ovarian reserve (dor) diagnosed by elevated early follicular-phase fsh levels. | 2011 | 21497340 |
| increased macrophage infiltration and neovascularization in congenital bicuspid aortic valve stenosis. | objectives: patients with congenital bicuspid aortic valves have aortic valve stenosis at a relatively young age compared with patients with tricuspid aortic valves. we hypothesize that aortic valve stenosis evolves from a more aggressive inflammatory process, with increased macrophage/t-cell and neovessel content in congenital bicuspid aortic valveswhen compared with that seen in tricuspid valves. methods: fifty-one severely stenotic aortic valves were obtained at the time of aortic valve repla ... | 2011 | 21481422 |
| an innovative approach to interdisciplinary occupational safety and health education. | the new york and new jersey education and research center (erc) provides a range of graduate continuing education for occupational safety and health (osh) professionals in training. a key element of the education is to provide interdisciplinary training to industrial hygienists, ergonomists, occupational medicine physicians and other health and safety trainees to prepare them for the collaboration required to solve the complex occupational health and safety problems they will face in their caree ... | 2011 | 21557281 |
| associations between herpes simplex virus type 2 and hcv with hiv among injecting drug users in new york city. | objectives. we examined relationships between herpes simplex virus type 2 (hsv-2), a biomarker for sexual risk, and hcv, a biomarker for injecting risk, with hiv among injecting drug users (idus) who began injecting after large-scale expansion of syringe exchange programs in new york city. methods. we recruited 337 heroin and cocaine users who began injecting in 1995 or later from persons entering drug detoxification. we administered a structured interview covering drug use and hiv risk behavior ... | 2011 | 21566021 |
| sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response. | background: sunitinib has activity in patients with metastatic urothelial cancer (uc), but most patients do not respond. objective: to identify predictors of response to sunitinib. design, setting, and participants: seventy-seven patients with advanced uc received sunitinib on one of two schedules at a single institution. blood pressure (bp), immunohistochemistry (ihc), and pharmacokinetic (pk) results were correlated with response to sunitinib. measurements: bp was assessed on day 1 and 28 of e ... | 2011 | 21645967 |
| testing. claims by man who falsely thought he had hiv may proceed. | | 2011 | 21585003 |
| single nucleotide polymorphisms in dna repair genes and association with breast cancer risk in the web study. | base excision and nucleotide excision repair pathways repair damaged dna, and polymorphisms in these genes might affect breast cancer susceptibility. we evaluated associations between 7 single nucleotide polymorphisms (snps) in 4 dna repair genes (ercc4 rs1799801, xpc rs2227998, rs2228001, rs2228000, ogg1 rs1052133, and xrcc1 rs25487 and rs25486) and breast cancer risk, examining modification by smoking and alcohol consumption, using data from the western new york exposures and breast cancer (we ... | 2011 | 21622940 |
| pik3ca mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression. | pik3ca gene mutations are the most common activating mutations in human breast cancer. its association with hormone receptor-positive breast cancer makes it a prime target for clinical therapeutic advances to maintain anti-estrogen responsiveness. in anticipation of this therapeutic approach, we have evaluated intratumoral heterogeneity in primary breast cancers with regard to pik3ca mutation status. in addition, we have assessed for the presence of the mutation in paired pre-invasive breast can ... | 2011 | 21617917 |
| human health risk assessment of synthetic turf fields based upon investigation of five fields in connecticut. | questions have been raised regarding possible exposures when playing sports on synthetic turf fields cushioned with crumb rubber. rubber is a complex mixture with some components possessing toxic and carcinogenic properties. exposure is possible via inhalation, given that chemicals emitted from rubber might end up in the breathing zone of players and these players have high ventilation rates. previous studies provide useful data but are limited with respect to the variety of fields and scenarios ... | 2011 | 21797769 |
| 'it was a freak accident': an analysis of the labelling of injury events in the us press. | objectives given that the news media shape our understanding of health issues, a study was undertaken to examine the use by the us media of the expression 'freak accident' in relation to injury events. this analysis is intended to contribute to the ongoing consideration of lay conceptualisation of injuries as 'accidents'. methods lexisnexis academic was used to search three purposively selected us news sources (associated press, new york times and philadelphia inquirer) for the expression 'freak ... | 2011 | 21659441 |
| exposure to lymphocytic choriomeningitis virus, new york, usa. | to the editor: lymphocytic choriomeningitis virus (lcmv) is an arenavirus carried by the house mouse, mus musculus. human infections can range from mild febrile illness to severe encephalitis and disseminated disease (1). infection during pregnancy is associated with teratogenic effects, including congenital hydrocephalus and chorioretinitis (2). | 2011 | 21762607 |
| hiv-2 infection surveillance --- united states, 1987--2009. | human immunodeficiency virus (hiv) is categorized into two types, hiv-1 and hiv-2. worldwide, most hiv infections are hiv-1, whereas hiv-2 largely has been confined to persons in or from west africa. hiv-1 and hiv-2 have the same routes of transmission, and both can cause acquired immunodeficiency syndrome (aids); however, hiv-2 infections should be differentiated from hiv-1 infections because they are less likely to cause aids and their clinical management differs. cdc's current surveillance ca ... | 2011 | 21796096 |
| sexual transmission of hepatitis c virus among hiv-infected men who have sex with men --- new york city, 2005--2010. | in the united states, an estimated 3.2 million persons are living with hepatitis c virus (hcv) infection. hcv transmission occurs primarily through percutaneous exposure to blood, and persons who inject drugs are at greatest risk for infection. the role of sexual transmission of hcv has not been well defined. however, reports over the past decade, mainly from europe, have implicated sexual transmission of hcv among human immunodeficiency virus (hiv)--infected men who have sex with men (msm). in ... | 2011 | 21775948 |
| interview: commercial translation of cell-based therapies and regenerative medicine: learning by experience. | dr haseltine speaks to emily culme-seymour, assistant commissioning editor william a haseltine, phd has an active career in both science and business. he was a professor at harvard medical school and harvard school of public health (ma, usa) from 1976 to 1993, where he was founder and chair of two academic research departments. he is well known for his pioneering work on cancer, hiv/aids and genomics. he has authored more than 200 manuscripts in peer-reviewed journals and is the author of severa ... | 2011 | 21749201 |
| lead, mercury, cadmium, chromium, and arsenic levels in eggs, feathers, and tissues of canada geese of the new jersey meadowlands. | the new jersey meadowlands are located within the heavily urbanized new york/new jersey harbor estuary and have been subject to contamination due to effluent and runoff from industry, traffic, and homes along the hackensack river and nearby waterways. these extensive wetlands, though heavily impacted by development and pollution, support a wide array of bird and other wildlife species. persistent contaminants may pose threats to birds in these habitats, affecting reproduction, egg hatchability, ... | 2011 | 21679937 |
| the ultimate benefit to be derived from the epidemic. | | 2011 | 21750280 |
| barriers to hiv testing among hiv/aids concurrently diagnosed persons in new york city. | : to assess barriers to human immunodeficiency virus (hiv) testing, health care contacts history, and hiv testing history among patients diagnosed concurrently with hiv and acquired immunodeficiency syndrome (aids). | 2011 | 21844723 |
| a survival analysis approach to modeling human fecundity. | understanding conception probabilities is important not only for helping couples to achieve pregnancy but also in identifying acute or chronic reproductive toxicants that affect the highly timed and interrelated processes underlying hormonal profiles, ovulation, libido, and conception during menstrual cycles. currently, 2 statistical approaches are available for estimating conception probabilities depending upon the research question and extent of data collection during the menstrual cycle: a su ... | 2011 | 21697247 |
| exome sequencing identified myo1e and neil1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. | to identify gene loci associated with steroid-resistant nephrotic syndrome (srns), we utilized homozygosity mapping and exome sequencing in a consanguineous pedigree with three affected siblings. high-density genotyping identified three segments of homozygosity spanning 33.6ôçëmb on chromosomes 5, 10, and 15 containing 296 candidate genes. exome sequencing identified two homozygous missense variants within the chromosome 15 segment; an a159p substitution in myosin 1e (myo1e), encoding a podocyte ... | 2011 | 21697813 |
| agent-based simulation for weekend-extension strategies to mitigate influenza outbreaks. | abstract: | 2011 | 21718518 |
| soul whisperers. | personal recollections are offered in reflection upon the tragedy of 9/11. the outreach efforts of the blanton-peale institute in conjunction with the health care chaplaincy of new york and the red cross are recalled by ceo emeritus, kathryn madden. a brief clinical study describes the responses of a young man who was one of only a few persons to make it out of the north tower from above the 85th floor. blanton-peale's benefit honorees brian clark, lauren and greg manning are named as survivors ... | 2011 | 21826557 |
| distributions of polyhalogenated compounds in hudson river (new york, usa) fish in relation to human uses along the river. | pcbs (as aroclor concentrations) have been extensively examined in fish along the hudson river, but other xenobiotic chemicals in fish have had limited assessment. this study determined concentrations and congener distributions of polybrominated diphenyl ethers (pbdes), polybrominated and polychlorinated dibenzo-p-dioxins and dibenzofurans (pbdd/fs and pcdd/fs), and polychlorinated biphenyls (pcbs) in smallmouth bass and striped bass taken from a 385km reach of the hudson river. concentrations o ... | 2011 | 21742424 |
| heat shock factor y chromosome (hsfy) mrna level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia. | to evaluate heat shock factor y chromosome (hsfy) mrna as a biomarker for the presence of retrievable testicular sperm. | 2011 | 21676392 |
| spatial patterns of mercury in biota of adirondack, new york lakes. | we studied the spatial distribution patterns of mercury (hg) in lake water, littoral sediments, zooplankton, crayfish, fish, and common loons in 44 lakes of the adirondacks of new york state, usa, a region that has been characterized as a "biological hg hotspot". our study confirmed this pattern, finding that a substantial fraction of the lakes studied had fish and loon samples exceeding established criteria for human and wildlife health. factors accounting for the spatial variability of hg in l ... | 2011 | 21691858 |
| The Rockefeller University Hospital (1910-2010): creating the science of medicine. | The year 2010 marked the centennial of the Rockefeller University Hospital, one of the great philanthropic achievements of 20th-century science. For 100 years, the Hospital played a central role in the development and growth of medical science by enabling physician-scientists to make intensive study of human biology and disease. With ingenuity and devotion, they greatly enriched clinical medicine as well as basic biological science. This account emphasizes the founding and first half-century of ... | 2011 | 21857122 |
| Promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism. | Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation. We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-ß(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study. Real-time methylation-specific PCR was perform ... | 2011 | 21916701 |
| predictive mapping of human risk for west nile virus (wnv) based on environmental and socioeconomic factors. | a west nile virus (wnv) human risk map was developed for suffolk county, new york utilizing a case-control approach to explore the association between the risk of vector-borne wnv and habitat, landscape, virus activity, and socioeconomic variables derived from publically available datasets. results of logistic regression modeling for the time period between 2000 and 2004 revealed that higher proportion of population with college education, increased habitat fragmentation, and proximity to wnv po ... | 2011 | 21853103 |
| predictors of acceptance of h1n1 influenza vaccination by fdny firefighters and ems workers. | there is a widely recognized need for vaccination of health care workers (hcws). we undertook this study to assess the 2009-2010 h1n1 vaccination rates in ôê+14,000 firefighters and emergency medical service (ems) workers at the fire department of new york (fdny) and to determine predictors of h1n1 vaccine acceptance. | 2011 | 21693157 |
| association of rad51 polymorphism with dna repair in brca1 mutation carriers and sporadic breast cancer risk. | abstract: | 2011 | 21708019 |
| decelerating spread of west nile virus by percolation in a heterogeneous urban landscape. | vector-borne diseases are emerging and re-emerging in urban environments throughout the world, presenting an increasing challenge to human health and a major obstacle to development. currently, more than half of the global population is concentrated in urban environments, which are highly heterogeneous in the extent, degree, and distribution of environmental modifications. because the prevalence of vector-borne pathogens is so closely coupled to the ecologies of vector and host species, this het ... | 2011 | 21829332 |
| bat rabies and human postexposure prophylaxis, new york, usa. | | 2011 | 22172493 |
| a randomized trial of a behavioral intervention for black men who have sex with men: the dish study. | objective:: to test a new behavioral intervention for black men who have sex with men in reducing sexual risk and increasing social support and intentions to use condoms. design:: a single site, unblinded randomized trial in new york city with 3-month follow-up. methods:: participants (n = 283) reporting at least 2 sexual partners and unprotected anal intercourse with a man in the past 3 months were enrolled and randomized to a social-cognitive theory based intervention or control comparison. me ... | 2011 | 22156967 |
| acute illnesses associated with insecticides used to control bed bugs--seven states, 2003--2010. | the common bed bug, cimex lectularius, is a wingless, reddish-brown insect that requires blood meals from humans, other mammals, or birds to survive. bed bugs are not considered to be disease vectors, but they can reduce quality of life by causing anxiety, discomfort, and sleeplessness. bed bug populations and infestations are increasing in the united states and internationally. bed bug infestations often are treated with insecticides, but insecticide resistance is a problem, and excessive use o ... | 2011 | 21937972 |
| stem cells. where do human eggs come from? | | 2011 | 21980085 |
| Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among children. | Perchlorate, nitrate and thiocyanate are ubiquitous in the environment, and human exposure to these chemicals is accurately measured in urine. Biomarkers of these chemicals represent a person's recent exposure, however, little is known on the temporal variability of the use of a single measurement of these biomarkers. Healthy Hispanic and Black children (6-10-year-old) donated urine samples over 6 months. To assess temporal variability, we used three statistical methods (n=29; 153 urine samples) ... | 2011 | 22166811 |
| molecular detection of viral causes of encephalitis and meningitis in new york state. | the etiology of encephalitis and meningitis, serious diseases of the central nervous system (cns), in most cases remains unknown. the importance of establishing a diagnosis however, becomes even more important as advances are made in effective therapy. molecular methods of detection, in particular, pcr, are being used routinely and have established a place in the arsenal of tools for diagnosis of cns infections. in this study a viral etiological agent was detected by pcr in 340 of the total 2,35 ... | 2011 | 22012726 |
| a community mobilizes to end medical apartheid. | problem: people of color suffer worse health outcomes than their white counterparts due, in part, to limited access to high-quality specialty care. purpose: this article describes the events that led to the bronx health reach coalition's decision to file a civil rights complaint with the new york state office of the attorney general alleging that three academic medical centers in new york city discriminated on the basis of payer status and race in violation of title vi of the civil rights ... | 2011 | 22080781 |
| Fish consumption, low-level mercury, lipids, and inflammatory markers in children. | There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9-11 year old children (N=100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Childre ... | 2011 | 22030286 |
| agents of human anaplasmosis and lyme disease at camp ripley, minnesota. | the transmission dynamics of anaplasma phagocytophilum (ap) and borrelia burgdorferi (bb) among ixodes scapularis (is) and mammalian hosts was investigated at camp ripley, an area representative of central minnesota. prevalence of white-footed mouse infection with ap and bb were 20% and 42%, respectively, with a coinfection level of 14%. peak levels of infection with both agents occurred in may. the average levels of seropositivity to ap and bb were 29.3% and 48%, respectively. of the mice infec ... | 2011 | 21867420 |
| modeling spatial variations of black carbon particles in an urban highway-building environment. | highway-building environments are prevalent in metropolitan areas. this paper presents our findings in investigating pollutant transport in a highway-building environment by combing field measurement and numerical simulations. we employ and improve the comprehensive turbulent aerosol dynamics and gas chemistry (ctag) model to simulate the spatial variations of black carbon (bc) concentrations near highway i-87 and an urban school in the south bronx, new york. the results of ctag simulations are ... | 2011 | 22084971 |
| temporally structured metapopulation dynamics and persistence of influenza a h3n2 virus in humans. | populations of seasonal influenza virus experience strong annual bottlenecks that pose a considerable extinction risk. it has been suggested that an influenza source population located in tropical southeast or east asia seeds annual temperate epidemics. here we investigate the seasonal dynamics and migration patterns of influenza a h3n2 virus by analysis of virus samples obtained from 2003 to 2006 from australia, europe, japan, new york, new zealand, southeast asia, and newly sequenced viruses f ... | 2011 | 22084096 |
| comparison of health outcomes among affiliated and lay disaster volunteers enrolled in the world trade center health registry. | volunteers (non-professional rescue/recovery workers) are universally present at man-made and natural disasters and share experiences and exposures with victims. little is known of their disaster-related health outcomes. | 2011 | 21930152 |
| Evaluating the combined effectiveness of influenza control strategies and human preventive behavior. | Control strategies enforced by health agencies are a major type of practice to contain influenza outbreaks. Another type of practice is the voluntary preventive behavior of individuals, such as receiving vaccination, taking antiviral drugs, and wearing face masks. These two types of practices take effects concurrently in influenza containment, but little attention has been paid to their combined effectiveness. This article estimates this combined effectiveness using established simulation models ... | 2011 | 22043275 |
| fate of perchlorate in a man-made reflecting pond following a fireworks display in albany, new york, usa. | perchlorate is a widespread contaminant in aquatic environments. despite this, the aquatic environmental fate of perchlorate released from fireworks displays is not well known. in the present study, we examined the fate of perchlorate in man-made reflecting ponds, from 2008 to 2010, following three fireworks displays in albany, new york, usa. immediately after the fireworks display, perchlorate in pond waters increased significantly, with concentrations from 30 to 1,480 times higher than the bas ... | 2011 | 21850663 |
| inotropic contractile reserve can risk-stratify patients with hiv cardiomyopathy: a dobutamine stress echocardiography study. | the purpose of this study was to assess whether inotropic contractile reserve (icr) during dobutamine stress echocardiography (dse) could risk-stratify patients with human immunodeficiency virus (hiv) cardiomyopathy and predict improvement of left ventricular ejection fraction (lvef). | 2011 | 22172778 |