| extranodal natural killer/t-cell lymphoma, nasal type in taiwan: a relatively higher frequency of t-cell lineage and poor survival for extranasal tumors. | extranodal natural killer (nk)/t-cell lymphoma, nasal type, is a predominantly extranodal lymphoma associated with epstein-barr virus occurring most frequently in the upper aerodigestive tract. there are limited reports on cellular origin and prognostic factors. we retrospectively investigated 73 cases with a median age of 54 years and a male-female ratio of 2.0:1. the upper aerodigestive tract (nasal group) was the most common site of involvement (51 cases; 70%). the other organs (n = 22; extra ... | 2015 | 25554090 |
| ebv-associated burkitt lymphoma in taiwan is not age-related. | this study retrospectively investigated 54 cases of sporadic burkitt lymphoma in taiwan with histopathology review, immunohistochemistry, epstein-barr virus (ebv) in situ hybridization (eber) and fluorescence in situ hybridization (fish). the great majority revealed typical immunophenotype and 89% (47/53) cases expressed myc protein. eber was positive in 20% (11/54) of cases, more frequently with nodal presentation, but not significantly associated with age (pediatric vs. adult), abdominal vs. e ... | 2016 | 26422188 |
| clinical characteristics and treatment outcome in a taiwanese population of patients with epstein-barr virus-positive diffuse large b-cell lymphoma. | epstein-barr virus-positive diffuse large b-cell lymphoma is a provisional entity in the 2008 world health organization classification of tumors of hematopoietic and lymphoid tissues. reports on the characteristics and clinical outcome of this disease in different geographic regions showed great disparities. | 2014 | 25320341 |
| birth order and risk of nasopharyngeal carcinoma in multiplex families from taiwan. | a small proportion of individuals infected with epstein-barr virus (ebv) develop nasopharyngeal carcinoma (npc). timing of initial exposure could alter immunological responses to primary ebv infection and explain variation in cancer risk later in life. we measured early life family structure as a proxy for the timing of primary ebv infection to examine whether earlier age at infection alters npc risk. we utilized data from 480 npc cases and 1,291 unaffected siblings from taiwanese npc multiplex ... | 2016 | 27537611 |
| prevalence of human papillomavirus and epstein-barr virus in salivary gland diseases. | the roles of human papillomavirus (hpv) and epstein-barr virus (ebv) in head and neck neoplasms have been well reported, but little is known about their relationship with salivary gland tumours. this study investigated the presence of hpv and ebv in salivary gland diseases. | 2014 | 25136053 |
| spectrum of epstein-barr virus-associated t-cell lymphoproliferative disorder in adolescents and young adults in taiwan. | epstein-barr virus (ebv) is a herpesvirus usually infecting b-cells but may occasionally infect t- or natural killer (nk)-cells. ebv-associated t- or nk-cell lymphoproliferations represent a continuous spectrum of diseases ranging from asymptomatic infection, infectious mononucleosis (im), to clonal and malignant lymphoproliferations including systemic ebv-positive t/nk-cell lymphoproliferative disease (ebv-t/nk-lpd) of childhood and hydroa-vacciniforme-like lymphoma of the skin. the clonal dise ... | 2014 | 24966953 |
| familial tendency and risk of nasopharyngeal carcinoma in taiwan: effects of covariates on risk. | in the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (npc) of male participants in an npc multiplex family cohort with that of controls in a community cohort in taiwan after adjustment for anti-epstein-barr virus (ebv) seromarkers and cigarette smoking. a total of 43 incident npc cases were identified from the 1,019 males in the npc multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, ... | 2010 | 21148719 |
| primary intestinal diffuse large b-cell lymphoma in taiwan showed a relative higher rate of perforation and ebv association. | we retrospectively investigated 59 surgically resected primary intestinal diffuse large b-cell lymphomas (pi-dlbcl) including 31 males and 28 females with a median age of 66. eleven (19%) tumors were perforated at presentation; 8 (14%) were multicentric. ileum (n=24; 43%) and ileocecum (n=17; 30%) were most frequently involved. twenty-one (36%) patients did not receive chemotherapy or radiotherapy including 6 with perforation and died in 0.2 to 7 months. the 1-, 2-, and 5-year overall survival r ... | 2016 | 26258754 |
| angioimmunoblastic t-cell lymphoma in taiwan shows a frequent gain of itk gene. | angioimmunoblastic t-cell lymphoma (aitl) is an aggressive peripheral t-cell lymphoma (ptcl) of follicular helper t-cell origin and is rare in taiwan. there are overlapping features of aitl and peripheral t-cell lymphoma with a follicular growth pattern (ptcl-f). around one fifth of ptcl-f exhibits t(5;9)(q33;q22)/itk-syk chromosomal translocation, which is essentially absent in aitl. we retrospectively investigated 35 cases of aitl from taiwan with histopathology review, immunohistochemistry, i ... | 2014 | 25337257 |
| epstein-barr virus serology as a potential screening marker for nasopharyngeal carcinoma among high-risk individuals from multiplex families in taiwan. | nasopharyngeal carcinoma (npc) is an epstein-barr virus (ebv)-associated cancer that is highly treatable when diagnosed early, with 5-year disease-free survival of approximately 90%. however, npc is typically diagnosed at advanced stages, in which disease-free survival is <50%. there is, therefore, a need for clinical tools to assist in early npc detection, particularly among high-risk individuals. | 2014 | 24769890 |
| adult t-cell leukaemia/lymphoma can mimic other lymphomas in a non-endemic area: dilemmas in diagnosis and treatment. | the diagnosis of adult t-cell leukaemia/lymphoma (atl) in non-endemic regions is challenging. | 2014 | 24533861 |
| high seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. | systemic lupus erythematosus (sle) is an autoimmune disease that is associated with genetic and environmental factors and microbial infection. with respect to microbial infection, the epstein-barr virus (ebv) has been a widely discussed issue in recent decades. human herpesvirus 8 (hhv-8) belongs to the same γ-herpesvirus subfamily as ebv and is closely related to it. until now, only one paper has reported the prevalence of hhv-8 infection in sle patients. the goal of this study was to detect th ... | 2013 | 24283670 |
| epstein-barr virus is rarely associated with diffuse large b cell lymphoma in taiwan and carries a trend for a shorter median survival time. | epstein-barr virus (ebv)-positive diffuse large b cell lymphoma (dlbcl) of the elderly is characterised by frequent extranodal involvement, a morphological spectrum from polymorphous to monomorphous and a poor prognosis. the frequency is higher in japan and korea but lower in the west, while the status in taiwan has not been reported yet. | 2014 | 24218026 |
| evaluation of nasal and nasopharyngeal swab collection for the detection of epstein-barr virus in nasopharyngeal carcinoma. | ebv detection using nasopharyngeal swabs has been suggested as a potential screening test that could improve the specificity of current ebv-based serological assays. however, application requires insertion of the swab deep into the nasopharynx, a procedure not amenable to non-clinic screening. we reasoned that swabbing the more easily accessible nasal cavity might provide an appealing alternative for npc detection. | 2017 | 28833336 |