Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| increased health burden associated with clostridium difficile diarrhoea in patients with inflammatory bowel disease. | background clostridium difficile (c. difficile) infection in hospitals in developed countries continues to be a major public health hazard despite increased control measures including review of antibiotic policies and hygiene measures. patients with colitis are thought to be particularly vulnerable to c. difficile associated diarrhoea (cdad). identifying the clinical burden among hospitalised patients admitted with inflammatory bowel disease is an essential first step towards identifying and tr ... | 2011 | 21517920 |
| recommendations for surveillance priorities for healthcare-associated infections and criteria for their conduct. | surveillance and feedback of results to clinical teams is central to performance improvement in managing healthcare-acquired infections. a major role of the advisory committee on antimicrobial resistance and healthcare-associated infections (arhai) is to advise on surveillance priorities. a sub-committee was set up to systematically review existing uk surveillance schemes. the following three systems were examined in detail: mandatory reporting of methicillin-resistant staphylococcus aureus (mrs ... | 2012 | 22855875 |
| changing epidemiology of clostridium difficile infection following the introduction of a national ribotyping-based surveillance scheme in england. | marked increases in clostridium difficile infection (cdi) incidence, driven by epidemic strain spread, is a global phenomenon. | 2012 | 22784871 |
| clinical negligence, litigation and healthcare-associated infections. | litigation costs resulting from clinical negligence claims involving healthcare-associated infections are a significant but underappreciated cost to healthcare organizations. in england these claims are handled on behalf of the national health service (nhs) organizations by the nhs litigation authority (nhsla). the total number of claims and the amounts awarded have increased significantly in recent years. | 2012 | 22658237 |
| evaluation of the national cleanyourhands campaign to reduce staphylococcus aureus bacteraemia and clostridium difficile infection in hospitals in england and wales by improved hand hygiene: four year, prospective, ecological, interrupted time series study. | to evaluate the impact of the cleanyourhands campaign on rates of hospital procurement of alcohol hand rub and soap, report trends in selected healthcare associated infections, and investigate the association between infections and procurement. | 2012 | 22556101 |
| epidemiological survey of clostridium difficile ribotypes in the north east of england during an 18-month period. | during an 18-month period, 1606 stool specimens from laboratory-confirmed cases of clostridium difficile infection in the north east of england were ribotyped using unrestricted polymerase chain reaction. of these, 87.6% grew c. difficile on culture; 70% had one of 10 recognizable ribotypes of which 001, 106 and 027 were the most prevalent. the proportions of ribotypes 002 and 015 declined during the study period, whereas ribotypes 016 and 023 increased. ribotype 005 was significantly more numer ... | 2012 | 22633277 |
| assessment of administrative data for evaluating the shifting acquisition of clostridium difficile infection in england. | little is known about the acquisition of clostridium difficile infection (cdi) and whether it represents hospital- or community-acquired infection. | 2012 | 22306443 |
| increased hospital length of stay attributable to clostridium difficile infection in patients with four co-morbidities: an analysis of hospital episode statistics in four european countries. | hospital-onset clostridium difficile infection (cdi) places a significant burden on health care systems throughout europe, estimated at around €3 billion per annum. this burden is shared between national payers and hospitals that support additional bed days for patients diagnosed with cdi while in hospital or patients re-admitted from a previous hospitalisation. this study was performed to quantify additional hospital stay attributable to cdi in four countries, england, germany, spain, and the n ... | 2013 | 23797490 |
| impact of cleaning and other interventions on the reduction of hospital-acquired clostridium difficile infections in two hospitals in england assessed using a breakpoint model. | clostridium difficile infection remains a major challenge for hospitals. although targeted infection control initiatives have been shown to be effective in reducing the incidence of hospital-acquired c. difficile infection, there is little evidence available to assess the effectiveness of specific interventions. | 2013 | 23787167 |
| uk renal registry 16th annual report: chapter 15 epidemiology of reported infections amongst patients receiving dialysis for established renal failure in england from may 2011 to april 2012: a joint report from public health england and the uk renal registry. | infection remains one of the leading causes of mortality in established renal failure patients receiving renal replacement therapy (rrt). since 2007, centres providing rrt in england have been asked to provide additional data on patients with methicillin resistant staphylococcus aureus (mrsa) bacteraemia. since 2011, the option to provide data on methicillin sensitive stapylococcus aureus (mssa) and escherichia coli bacteraemia, as well as clostridium difficile infection has also been available. | 2013 | 24662179 |
| ribotyping in the detection of clostridium difficile outbreaks in a single university hospital. | clostridium difficile infection (cdi) is the most important bacterial cause of hospital-acquired diarrhoea. although reports of deaths associated with cdi have been decreasing since a peak in 2007 in england and northern ireland, it remains a major cause of morbidity and mortality. the health protection agency's clostridium difficile ribotyping network (cdrn) aims to provide information to help optimize the management of cases of cdi. this study assesses the value of ribotyping to detect outbrea ... | 2013 | 23158685 |
| nosocomial transmission of c. difficile in english hospitals from patients with symptomatic infection. | recent evidence suggests that less than one-quarter of patients with symptomatic nosocomial clostridium difficile infections (cdi) are linked to other in-patients. however, this evidence was limited to one geographic area. we aimed to investigate the level of symptomatic cdi transmission in hospitals located across england from 2008 to 2012. | 2014 | 24932484 |
| international prevalence of adverse drug events in hospitals: an analysis of routine data from england, germany, and the usa. | adverse drug events (ades) are frequent in hospitals, occurring either in patients before admission or as a nosocomial event, and either as a drug reaction or as a consequence of a medication error. routine data primarily recorded for reimbursement purposes are increasingly being used on a national level both in pharmacoepidemiological studies and in trigger tools. the aim of this study was to compare the prevalence rates of coded ades in hospitals on a transnational level. | 2014 | 24620750 |
| clostridium difficile toxin testing by national health service (nhs) acute trusts in england: 2008-2013. | in october 2007, a governmental 3-year target to reduce clostridium difficile infection (cdi) by 30%, with financial penalties levied for failure, was introduced in england. this target was met within just 1 year, leading to speculation of 'gaming', with hospitals empirically treating possible cdi in the absence of a microbiological diagnosis, to avoid having to report confirmed cases. an analysis of aggregate mandatory data on levels of testing for c. difficile toxin showed little evidence of a ... | 2015 | 25964154 |
| antibiotic policies in acute english nhs trusts: implementation of 'start smart-then focus' and relationship with clostridium difficile infection rates. | the objective of this study was to establish how antibiotic prescribing policies at national health service (nhs) hospitals match the england department of health 'start smart-then focus' recommendations and relate to clostridium difficile infection (cdi) rates. | 2015 | 25538165 |
| analysis of interventions to reduce the incidence of clostridium difficile infection at a london teaching hospital trust, 2003-2011. | since 2008 there has been a substantial fall in the incidence of clostridium difficile infection (cdi) in the uk, though it is unclear what contribution local and governmental interventions have made to this reduction. | 2015 | 25480022 |
| longitudinal trends and cross-sectional analysis of english national hospital antibacterial use over 5 years (2008-13): working towards hospital prescribing quality measures. | there is global concern that antimicrobial resistance is a major threat to healthcare. antimicrobial use is a primary driver of resistance but little information exists about the variation in antimicrobial use in individual hospitals in england over time or comparative use between hospitals. the objective of this study was to collate, analyse and report issue data from pharmacy records of 158 national health service (nhs) acute hospitals. | 2015 | 25304646 |
| genomic epidemiology of a protracted hospital outbreak caused by a toxin a-negative clostridium difficile sublineage pcr ribotype 017 strain in london, england. | clostridium difficile remains the leading cause of nosocomial diarrhea worldwide, which is largely considered to be due to the production of two potent toxins: tcda and tcdb. however, pcr ribotype (rt) 017, one of five clonal lineages of human virulent c. difficile, lacks tcda expression but causes widespread disease. whole-genome sequencing was applied to 35 isolates from hospitalized patients with c. difficile infection (cdi) and two environmental ward isolates in london, england. the phylogen ... | 2015 | 26179308 |
| management of patients with suspected infectious diarrhoea in hospitals in england. | advances in molecular and genomic testing for patients with suspected infectious diarrhoea are on the horizon. it is important to understand how infection control and microbiology departments currently operate with respect to the management of these patients in order to assess the implications of more widespread diagnostic testing. however, there are few data available on current practice in this context. | 2015 | 25997802 |
| the impact of the introduction of fidaxomicin on the management of clostridium difficile infection in seven nhs secondary care hospitals in england: a series of local service evaluations. | clostridium difficile infection (cdi) is associated with high mortality. reducing incidence is a priority for patients, clinicians, the national health service (nhs) and public health england alike. in june 2012, fidaxomicin (fdx) was launched for the treatment of adults with cdi. the objective of this evaluation was to collect robust real-world data to understand the effectiveness of fdx in routine practice. in seven hospitals introducing fdx between july 2012 and july 2013, data were collected ... | 2016 | 26661400 |
| bed utilisation and increased risk of clostridium difficile infections in acute hospitals in england in 2013/2014. | the study aimed to identify thresholds for hospital bed utilisation which are independently associated with significantly higher risks for clostridium difficile infections (cdi) in acute hospitals in england. | 2016 | 27601687 |
| interview with professor mark wilcox. | mark wilcox speaks to georgia patey, commissioning editor: professor mark wilcox is a consultant microbiologist and head of microbiology at the leeds teaching hospitals (leeds, uk), the professor of medical microbiology at the university of leeds (leeds, uk), and is the lead on clostridium difficile and the head of the uk c. difficile reference laboratory for public health england (phe). he was the director of infection prevention (4 years), infection control doctor (8 years) and clinical direct ... | 2016 | 27494150 |
| enhanced surveillance of clostridium difficile infection occurring outside hospital, england, 2011 to 2013. | there are limited national epidemiological data for community-associated (ca)-clostridium difficile infections (cdis). between march 2011 and march 2013, laboratories in england submitted to the clostridium difficile ribotyping network (cdrn) up to 10 diarrhoeal faecal samples from successive patients with ca-cdi, defined here as c. difficile toxin-positive diarrhoea commencing outside hospital (or less than 48 hours after hospital admission), including those cases associated with community-base ... | 2016 | 27487436 |
| polonium-210 poisoning: a first-hand account. | polonium-210 ((210)po) gained widespread notoriety after the poisoning and subsequent death of mr alexander litvinenko in london, uk, in 2006. exposure to (210)po resulted initially in a clinical course that was indistinguishable from infection or exposure to chemical toxins, such as thallium. | 2016 | 27461439 |
| uk renal registry 18th annual report: chapter 12 epidemiology of reported infections amongst patients receiving dialysis for established renal failure in england 2013 to 2014: a joint report from public health england and the uk renal registry. | from 1st may 2013 to 30th april 2014 there were 35 episodes of methicillin resistant staphylococcus aureus (mrsa) bacteraemia in established renal failure patients on dialysis. this is now fairly stable year-on-year equating to a rate of 0.15 episodes per 100 dialysis patient years, following an initial decline in rates from 4.0 episodes per 100 dialysis patient years in 2005 when reporting began. methicillin sensitive staphylococcus aureus (mssa) bacteraemia rates were slightly higher this year ... | 2016 | 27116291 |
| second generation cephalosporin antibiotic prophylaxis and clostridium difficile infection in hip and knee arthroplasty. | introduction the use of broad spectrum cephalosporin antibiotics has been discouraged by the department of health in england because of the link to increased clostridium difficile infection rates. the aim of this study was to evaluate whether a local protocol that included the use of second generation cephalosporin (cefuroxime) antibiotics as a prophylactic agent was associated with increased risk of c difficile in elective hip and knee arthroplasty patients. methods a retrospective intention-to ... | 2017 | 28462657 |
| toxigenic clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. | to establish risk factors for clostridium difficile colonization among hospitalized patients in england. | 2017 | 28435086 |
| point-counterpoint: what is the optimal approach for detection of clostridium difficile infection? | introductionin 2010, we published an initial point-counterpoint on the laboratory diagnosis of clostridium difficile infection (cdi). at that time, nucleic acid amplification tests (naats) were just becoming commercially available, and the idea of algorithmic approaches to cdi was being explored. now, there are numerous naats in the marketplace, and based on recent proficiency test surveys, they have become the predominant method used for cdi diagnosis in the united states. at the same time, the ... | 2017 | 28077697 |
| investigation of community carriage rates of clostridium difficile and hungatella hathewayi in healthy volunteers from four regions of england. | faecal samples from 1365 healthy asymptomatic volunteers from four regions in england were screened for the presence of clostridium difficile between december 2013 and july 2014. the carriage rate of c. difficile in healthy patients was 0.5%, which is lower than reported previously. this study demonstrates that the true community reservoir of c. difficile in the healthy uk population is very low and is, therefore, unlikely to be a reservoir for infections diagnosed in the hospital setting. | 2017 | 28549779 |
| comparative epidemiology of clostridium difficile infection: england and the usa. | to examine whether there is an epidemiological difference between clostridium difficile infection (cdi) inpatient populations in england and the united states. | 2017 | 29025123 |