Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| chloroquine sensitivity of plasmodium falciparum in ibadan, nigeria. | thirty-five children with plasmodium falciparum malaria were treated with 25 mg/kg chloroquine over three days and observed for seven days during which blood films were examined daily for malaria parasites. asexual forms of p. falciparum which were present in the blood films of all the patients before commencing treatment disappeared rapidly from the blood so that by the third day no parasites were seen in the blood film. the blood films remained negative for the rest of the seven-day observatio ... | 1980 | 7001691 |
| the in vivo sensitivity of plasmodium falciparum to chloroquine and to sulphadoxine-pyrimethamine combination in ibadan, nigeria. | fifty-eight nigerian children with plasmodium falciparum malaria were allocated randomly into two groups and treated with either chloroquine (25 mg/kg over three days) or fansidar (35 mg sulphadoxin (+ 1/20 pyrimethamine) per kg single dose)). they were observed for 28 days during which blood films were examined periodically for malaria parasites. asexual forms of p. falciparum, which were present in the blood films of all the patients in both groups before commencing treatment, disappeared rapi ... | 1981 | 7036438 |
| chloroquine sensitivity of plasmodium falciparum in ibadan, nigeria: ii. correlation of in vitro with in vivo sensitivity. | plasmodium falciparum malaria was treated in 82 children with 25 mg/kg chloroquine orally over three days. they were observed for 28 days during which blood films were examined periodically for malaria parasites. asexual forms of p. falciparum, present in the blood films of all the patients before commencing treatment, disappeared rapidly and by the third day no parasites were seen in blood films from any of them. among the patients observed for more than three days, blood films remained negativ ... | 1981 | 7036425 |
| prevalence of antibodies to parasitic infections in nigerian children. | sixty-six sera from nigerian children who attended a paediatric clinic at university college hospital, ibadan were tested with plasmodium falciparum, p. brazilianum, entamoeba histolytica, toxoplasma gondii and schistosoma mansoni antigens using indirect fluorescent antibody technique. these sera were tested using elisa technique for schistosoma antibodies. sera from all proven cases of infections gave positive results. highest antibody prevalence rate was for p. falciparum (69.6%), followed by ... | 1981 | 7017156 |
| the sensitivity of plasmodium falciparum to chloroquine and amodiaquine in ibadan, nigeria. | an extended in vivo test of the sensitivity of plasmodium falciparum to antimalarial drugs in nigerian children showed no evidence of resistance to chloroquine and amodiaquine. however, the results of a small number of in vitro tests suggest a decreased sensitivity of the parasite to chloroquine when compared with the results of earlier studies in the same locality. | 1984 | 6398531 |
| intestinal helminthiasis and haemoparasitism in an area of endemic dracunculiasis in oyo state of nigeria. | in the course of a survey of human intestinal and haemoparasites in oluyole local government area of nigeria known to be endemic for dracunculiasis, most of the inhabitants were burdened with parasitic infections which include ascariasis (43.7%), hookworm infection (27.1%), trichuriasis (31%), strongyloidiasis (2.5%), entamoeba histolytica infestation (3.9%), e. coli infestation (2.7%) and plasmodiasis (43.7%). peak of ascariasis was among the 1-10 years age group while those of trichuriasis, ho ... | 1986 | 2944853 |
| malaria and loaisis among blood donors at ibadan, nigeria. | 115 blood donors were screened for the presence of malaria and other blood parasites at the blood bank, university college hospital, ibadan, between january and july, 1984. 11.3% of these had blood parasites; 7.8% had plasmodium falciparum with parasitaemias from 0.03-0.2%, and 3.5% had loa loa microfilaraemia. no other blood parasites were observed. serological examination by the indirect fluorescent antibody test revealed that 86% of the donors had malaria antibody with reciprocal titres rangi ... | 1987 | 3318017 |
| sensitivity of plasmodium falciparum to chloroquine, amodiaquine and mefloquine in ibadan, nigeria. | the schizontocidal effect of chloroquine was compared to that of amodiaquine in vivo and mefloquine in vitro. in the in-vivo study, 32 patients were randomly given chloroquine whilst 29 received amodiaquine. the mean parasite clearance time was 2.5 days for chloroquine and 2.4 days for amodiaquine. these times were not significantly different. the cure rate in both groups up to day 14 was 100%. in the in-vitro study, three isolates of plasmodium falciparum were compared for their sensitivity to ... | 1988 | 2834931 |
| evaluation of the clinical efficacy and safety of halofantrine in falciparum malaria in ibadan, nigeria. | fifty subjects with acute symptomatic uncomplicated falciparum malaria were treated orally with halofantrine hydrochloride 500 mg 6 hourly for 3 doses if their body weight was 40 kg and above, or 8 mg/kg body weight 6 hourly for 3 doses if their weight was below 40 kg. parasitaemia cleared in all subjects within 72 h. there was recurrence of parasitaemia in 9 subjects after day 14, and retreatment with halofantrine resulted in prompt clearance of parasitaemia in all but one of these patients. th ... | 1990 | 2278061 |
| sensitivity of plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in nigerian children. | the in vivo sensitivity of plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine was evaluated in children under 5 years of age in two areas of southern nigeria in 1987. a modification of the who standard field and extended tests (in vivo) was used, with follow-up on days, 2, 3, 7, and 14 after treatment with 25 mg chloroquine per kg body weight given over 3 days, or with standard doses of sulfadoxine/pyrimethamine. clinical and parasitological evaluations were performed. at igbo or ... | 1990 | 2189585 |
| continuous in-vitro cultivation of plasmodium falciparum in ibadan: solutions to scientific and logistical problems. | the technique of continuous in-vitro cultivation of plasmodium falciparum has not been widely applied in malaria-endemic areas, due to scientific as well as purely logistical problems. methods for solving or coping with these problems are described. they have already proved effective for over 4 years. the parasites harvested have been satisfactory, as judged by reproducible logarithmic growth curves and normal morphology in leishman-stained smears as well as phase-contrast microscopy of wet-prep ... | 1990 | 2115731 |
| congenital malaria in a hyperendemic area: a preliminary study. | the prevalence of plasmodium falciparum parasitaemia was evaluated in 59 neonates admitted to the university college hospital, ibadan in south-western nigeria between august and december 1991--a period spanning part of both wet and dry seasons. peripheral parasitaemia was present in 14 (23.7%) neonates; of these, four were preterm (4/26, 15%) and ten were term babies (10/33, 30.3%). the difference in the prevalence of p. falciparum parasitaemia in the two groups was not statistically significant ... | 1993 | 7505553 |
| asymptomatic malaria parasitaemia and seroreactivities to plasmodium falciparum antigens in blood donors from ibadan, south-western nigeria. | malaria parasite rates, parasite densities and seroreactivities to two plasmodium falciparum antigens (pf155/resa and circumsporozoite protein) were investigated in a random sample of 416 blood donors attending the blood transfusion unit of the university college hospital in ibadan, south-western nigeria: 224 in october-november 1991 and 192 in march 1992. the incidence of malaria parasitaeia observed in 1991 was significantly higher than that seen in 1992 (41% v. 19%; p < 0.001). in contrast, t ... | 1995 | 8745935 |
| interaction between acute diarrhoea and falciparum malaria in nigerian children. | although both malaria and diarrhoea are major public health problems in developing countries, and separately each has been the subject of intense research, few studies have investigated the interaction between these two conditions. the interaction between diarrhoea and malaria among children aged 4 months to 12 years in two tertiary health-care facilities, university college hospital, ibadan, and lagos university teaching hospital, lagos, nigeria was studied. in ibadan, the prevalence of diarrho ... | 1996 | 9203790 |
| evaluation of a rapid immunochromatographic card test for plasmodium falciparum in ibadan, nigeria. | this short report describes the results of a rapid, simple and cost effective immunodiagnostic test for malaria in ibadan, nigeria. a total of 77% patients presenting at the children outpatient clinic, university college hospital with malaria symptoms were screened for malaria parasites by microscopy using giemsa stain and by the immunochromatographic card test. the immunodiagnostic test had a sensitivity of 93.1% and a specificity of 95.8%, making a good alternative for malaria diagnosis especi ... | 2001 | 14510166 |
| point mutations in the pfcrt and pfmdr-1 genes of plasmodium falciparum and clinical response to chloroquine, among malaria patients from nigeria. | chloroquine (cq) resistance in plasmodium falciparum has been associated with specific point mutations in the pfcrt and pfmdr-1 genes. in the present study, 30 children aged 1-12 years, who were all suffering from acute, uncomplicated, p. falciparum malaria in ibadan, nigeria, were evaluated to assess the association between these mutations and clinical outcome following treatment with cq. the parasites, in blood samples collected pre-treatment and, in those who failed treatment, on the day symp ... | 2003 | 12930607 |
| molecular analysis of plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in nigeria. | parasite genotyping by a polymerase chain reaction was used to distinguish recrudescent from newly acquired plasmodium falciparum infections in 50 of 160 nigerian children taking part in a chloroquine efficacy study in ibadan, nigeria. a finger prick blood sample was taken from each child before and after treatment to identify recrudescent parasites. by investigating allelic variation in three polymorphic antigen loci, merozoite surface protein-1 (msp-1), msp-2, and glutamate-rich protein (glurp ... | 2004 | 14971693 |
| polymorphisms in plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from nigeria. | mutations in plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine-pyrimethamine (sp) and for monitoring/surveillance of resistance to the drug in many areas where malaria is endemic. however, patients responses to treatment are significantly dependent on factors like host immunity profile of treated patients. in order to investigate the relationship between molecular markers of sp resist ... | 2005 | 16023986 |
| genetic diversity of the msp-1 locus and symptomatic malaria in south-west nigeria. | genetic characteristics of plasmodium falciparum may play a role in the clinical severity of malaria infection. we have studied the association between diversity at the merozoite surface protein-1 (msp-1) locus and the severity of disease in childhood malaria in ibadan, south-west nigeria. two hundred and twenty-three children (median age of 34.5 months) presenting with malaria were enrolled into the study. they comprised 53 children with asymptomatic malaria (asm), 101 with acute uncomplicated ... | 2005 | 16023985 |
| plasmodium falciparum malaria in south-west nigerian children: is the polymorphism of icam-1 and e-selectin genes contributing to the clinical severity of malaria? | plasmodium falciparum malaria remains a major public health hazard in sub-saharan african children. while the factors that determine the variations in clinical outcome of a malaria have not been completely defined, both host and parasite factors, as well as the complex molecular interactions between them have been implicated. the cyto-adherent properties of the p. falciparum-infected red blood cells are considered as key properties in the pathogenesis of malaria and the polymorphisms of the host ... | 2005 | 16002039 |
| identification of three members of the anopheles funestus (diptera: culicidae) group and their role in malaria transmission in two ecological zones in nigeria. | the role of the anopheles funestus group in malaria transmission was investigated in two ecological zones in nigeria. sampling was carried out at four sites each around ibadan (forest) and ilorin (savanna). human landing catches were supplemented with indoor and outdoor resting collections. pcr was used to identify 1848 a. funestus group mosquitoes to species level (749 in the savanna, 1099 in the forest) and three species were identified. in the forest, a. funestus s.s. predominated (55.4%), fo ... | 2005 | 15869772 |
| increasing burden of childhood severe malaria in a nigerian tertiary hospital: implication for control. | malaria remains an important public heath concern in nigeria because of its impact on child and maternal health, but the contribution of severe malaria to morbidity among nigerian children was scantly reported. this study was undertaking to document the hospital-burden of severe malaria among children in ibadan in order to reflect on the impacts and health implications of the current malaria control strategies. a review of 6-year case records of all children admitted to the emergency ward of the ... | 2007 | 17287244 |
| high efficacy of two artemisinin-based combinations (artemether-lumefantrine and artesunate plus amodiaquine) for acute uncomplicated malaria in ibadan, nigeria. | to test the hypothesis that artesunate plus amodiaquine (asaq) is as effective as artemether-lumefantrine (al) in the treatment of acute uncomplicated malaria in nigerian children. | 2008 | 18346028 |
| complexity of the msp2 locus and the severity of childhood malaria, in south-western nigeria. | as the genetic diversity of plasmodium falciparum infections in humans is implicated in the pathogenesis of malaria, the association between p. falciparum diversity at the merozoite surface protein-2 (msp2) locus and the severity of childhood malaria was investigated in ibadan, in south-western nigeria. the 400 children enrolled had acute uncomplicated malaria (144), cerebral malaria (64), severe malarial anaemia (67) or asymptomatic infections with p. falciparum (125). nested pcr was used to in ... | 2008 | 18318931 |
| the burden of malaria infection on pregnant women and birth weight of infants in south western nigeria. | to determine the effect of malaria infection on pregnant women and the birth weight of the infants in the south western nigeria. | 2009 | 20000067 |
| cytokine profiles and antibody responses to plasmodium falciparum malaria infection in individuals living in ibadan, southwest nigeria. | the ability of the host immune system to efficiently clear plasmodium falciparum parasites during a malaria infection depends on the type of immune response mounted by the host. | 2009 | 19652739 |
| an open randomized clinical trial in comparing two artesunate-based combination treatments on plasmodium falciparum malaria in nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours). | several studies have demonstrated the efficacy of artemisinin-combination therapy (act) across malaria zones of the world. fixed dose act with shorter courses and fewer tablets may be key determinants to ease of administration and compliance. | 2010 | 21194422 |