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hospitalizations due to hepatitis c in los angeles county, 2007-2009: case characteristics and factors associated with mortality.morbidity and mortality due to hepatitis c (hcv) infection are rising in the united states as the highest risk cohort (those born between 1945 and 1965) ages. it is important for governments and healthcare providers to have timely, readily obtainable data to estimate the burden of hcv locally. demographic factors, hospital charges and comorbid conditions were summarized for los angeles county (lac) residents who had at least one hospitalization in california during 2007-2009 with hcv as a primar ...201323910647
clinical outcomes of hepatitis c treated with pegylated interferon and ribavirin via telemedicine consultation in northern california.patients in rural communities are less likely to receive treatment for their hepatitis c (hcv) infection. telemedicine (tm) consultation can close the gap of access to specialists in remote and under-served areas.201324154637
epidemiology of the viral hepatitis-hiv syndemic in san francisco: a collaborative surveillance approach.to describe the epidemiology of people coinfected with hepatitis b virus (hbv) or hepatitis c virus (hcv) and hiv in san francisco, the san francisco department of public health's communicable disease control and prevention section and the hiv epidemiology section collaborated to link their registries.201724385655
a pharmacist-managed telemedicine clinic for hepatitis c care: a descriptive analysis.we established a pharmacist-led telemedicine clinic to manage patients with chronic hepatitis c infection. the clinic used individual pharmacist-to-patient consultations. there was also a group hepatitis c patient education class. the hepatitis c telemedicine service began in february 2011 and was available at three remote sites (santa maria, bakersfield and east los angeles) from the main site in west los angeles. a total of 96 patients were seen through telemedicine in the first nine months. a ...201424414398
prevalence and presentation of hepatitis b and c virus (hbv and hcv) infection in vietnamese americans via serial community serologic testing.the prevalence of hepatitis b virus (hbv) infection is reportedly high in vietnamese americans (vas), but most previous studies did not assess full hbv serology, and not the prevalence of hbv and hepatitis c virus (hcv) infection simultaneously. the aim of the study is to assess the prevalence of different hbv serologies and hcv infection in vas. this study was based on the data collected by testing for hepatitis b surface antigen (hbsag), anti-hepatitis b core antibody (hbcab igg), anti-hbs ant ...201524474437
evaluating the impact of mexico's drug policy reforms on people who inject drugs in tijuana, b.c., mexico, and san diego, ca, united states: a binational mixed methods research agenda.policymakers and researchers seek answers to how liberalized drug policies affect people who inject drugs (pwid). in response to concerns about the failing "war on drugs," mexico recently implemented drug policy reforms that partially decriminalized possession of small amounts of drugs for personal use while promoting drug treatment. recognizing important epidemiologic, policy, and socioeconomic differences between the united states-where possession of any psychoactive drugs without a prescripti ...201424520885
individual and socio-environmental factors associated with unsafe injection practices among young adult injection drug users in san diego.unsafe injection practices significantly increase the risk of hepatitis c virus (hcv) and human immunodeficiency virus (hiv) infection among injection drug users (idus). we examined individual and socio-environmental factors associated with unsafe injection practices in young adult idus in san diego, california. of 494 idus, 46.9 % reported receptive syringe sharing and 68.8 % sharing drug preparation paraphernalia in the last 3 months. unsafe injection practices were associated with increased o ...201524920342
concordance of risk behavior reporting within hcv serodiscordant injecting partnerships of young injection drug users in san francisco, ca.young injection drug users (idu, under age 30) often inject with other idu, creating an environment for risk of blood-borne disease transmission through sharing of needles and drug preparation equipment. epidemiologic studies rely on self reported injection behavior data for measures of transmission risk, therefore we sought to quantify the degree of concordance of reported injecting risk behaviors between injecting dyads.201425034898
intimate injection partnerships are at elevated risk of high-risk injecting: a multi-level longitudinal study of hcv-serodiscordant injection partnerships in san francisco, ca.it is increasingly recognized that the risk for hiv and hepatitis c (hcv) transmission among people who inject drugs (pwid), such as syringe sharing, occurs in the context of relationships between (at least) two people. evidence suggests that the risk associated with injection behavior varies with injection partner types.201425286346
trends in use of health care and hiv prevention services for persons who inject drugs in san francisco: results from national hiv behavioral surveillance 2005-2012.multiple developments addressing health of people who inject drugs (pwids) in san francisco were initiated from 2003 to 2012, including expanded health care coverage, syringe access, hiv testing and universal hiv treatment.201525468816
differences in response to antiretroviral therapy by sex and hepatitis c infection status.hepatitis c virus (hcv) co-infection and biological sex may each affect response to antiretroviral therapy (art), yet no studies have examined hiv-associated outcomes by both hcv status and sex. we conducted a cohort study of hiv-infected adults initiating art in kaiser permanente california during 1996-2011. we used piecewise linear regression to assess cd4 changes by sex and hcv status over 5 years. we used cox regression to estimate hazard ratios (hr) by sex and hcv status for hiv rna <500 co ...201526061798
comparative clinical effectiveness and value of novel interferon-free combination therapy for hepatitis c genotype 1: summary of california technology assessment forum report. 201526167717
effect of legal status of pharmacy syringe sales on syringe purchases by persons who inject drugs in san francisco and san diego, ca.sharing blood-contaminated syringes is the main risk factor for acquiring and transmitting blood-borne infections among persons who inject drugs (pwid). to reduce this risk, in 2005, california enacted legislation allowing local health jurisdictions to legalize non-prescription syringe sales after approving a disease prevention demonstration project (dpdp). with san francisco approving a dpdp immediately and san diego never approving one, we compared pwid across cities for their use of pharmacie ...201526252980
characteristics of aa amyloidosis patients in san francisco.aa amyloidosis due to subcutaneous injection of drugs of abuse has been described in the usa, but all the existing literature is from more than 20 years ago. there is more recent literature from europe. we have observed a high incidence of aa amyloidosis in the county hospital in san francisco.201626370715
hepatitis c infection among hispanics in california.hispanics in california are more likely to be infected with hepatitis c, and those infected have had their infection detected later. a total of 1,567 hispanic and caucasian individuals were tested for antibodies to hepatitis c from 2000 through 2013. interviewers administered the risk behavior assessment. hepatitis c-infected hispanics were incarcerated longer than hepatitis c-infected caucasians, and they used marijuana less and illicit methadone more. they were more likely to use crack, heroin ...201526372008
prevalence and correlates of the use of prefilled syringes among persons who inject drugs in san diego, ca.persons who inject drugs (pwid) are at increased risk for blood-borne virus (bbv) infections and overdose resulting from high-risk injecting practices. studies of prefilled syringe use ([pfsu] using a syringe that already contained drug solution when it was obtained by the user), an injection practice previously described in eastern europe, suggest that it increases susceptibility to bbv. however, little is known about this practice in the usa. data were obtained from an ongoing cohort study of ...201526382653
low prevalence of hepatitis c co-infection in recently hiv-infected minority men who have sex with men in los angeles: a cross-sectional study.geographic and sociodemographic characterization of hepatitis c virus (hcv) transmission amongst men who have sex with men (msm) has been limited. our aim was to characterize hcv prevalence, risk factors for hcv co-infection, and patterns of hiv and hcv co-transmission and transmitted drug resistance mutations (drms) in newly hiv-diagnosed los angeles msm.201526590028
hcv prevalence in asian americans in california.the world health organization estimates that 170 million persons are infected with hcv worldwide, but only 22 million are from the americas and europe, compared to 94 million from asia. hcv prevalence in the general us population is 1.6 %, but data for asian americans are limited. our goal was to examine hcv prevalence in asian americans in a large ethnically diverse patient cohort seeking primary care at a free clinic in northern california. a total of 1347 consecutive patients were seen from s ...201726798070
awareness of hepatitis c virus seropositivity and chronic infection in the hispanic community health study/study of latinos (hchs/sol).few population-based studies have assessed awareness of hepatitis c virus (hcv) seropositivity and chronic infection. we report awareness of hcv seropositivity and chronic infection and correlates of awareness in a multi-city (bronx, miami, chicago, and san diego) community-dwelling population sample of united states (us) hispanics/latinos recruited during 2008-2011. included were 260 hcv-seropositive participants, among whom 190 had chronic hcv. among those with chronic hcv, 46 % had been told ...201626864380
hepatitis c screening rate among underserved adults with serious mental illness receiving care in california community mental health centers.although hcv is more prevalent among people with severe mental illness (smi; e.g., schizophrenia, bipolar disorder) than in the general population (17% vs 1%), no large previous studies have examined hcv screening in this population. in this cross-sectional study, we examined administrative data for 57 170 california medicaid enrollees with smi to identify prevalence and predictors of hcv screening from october 2010 through september 2011. only 4.7% (2674 of 57 170) received hcv screening, with ...201626890183
the significance of harm reduction as a social and health care intervention for injecting drug users: an exploratory study of a needle exchange program in fresno, california.infectious disease remains a significant social and health concern in the united states. preventing more people from contracting hiv/aids or hepatitis c (hcv), requires a complex understanding of the interconnection between the biomedical and social dimensions of infectious disease. opiate addiction in the us has skyrocketed in recent years. preventing more cases of hiv/aids and hcv will require dealing with the social determinants of health. needle exchange programs (neps) are based on a harm r ...201727167664
increasing hepatitis b testing and linkage to care of foreign-born asians, sacramento, california, 2012-2013.without medical intervention, about one-quarter of the 1.4-2.2 million americans chronically infected with the hepatitis b virus (hbv) will die of hbv-associated conditions, including liver failure and hepatocellular carcinoma. we report on a program in sacramento county, california, that offered hbv screening to at-risk adults, referred infected individuals to care, and vaccinated uninfected adults who were susceptible to hbv infection (i.e., individuals who tested negative for hepatitis b surf ...201727168671
notes from the field: investigation of hepatitis c virus transmission associated with injection therapy for chronic pain - california, 2015.on november 26, 2014, the california department of public health (cdph) contacted cdc concerning a report from the santa barbara county public health department (sbphd) regarding acute hepatitis c virus (hcv) infection in a repeat blood donor. the patient, who was asymptomatic, was first alerted of the infection by the blood bank and had no traditional risk factors for hcv infection. the donor had a negative hcv nucleic acid test (nat) 56 days before the first positive nat test, and an investiga ...201627254396
the redesign of consumer cost sharing for specialty drugs at the california health insurance exchange.this paper describes the redesign of health benefits at covered california-the nation's largest health insurance exchange, which covers 1.3 million individuals, and its benefit designs extending to hundreds of thousands more enrollees through insurance products sold outside the exchange-with respect to specialty drugs for the 2016 enrollment year. the catalyst for benefit redesign came from advocacy organizations representing patients suffering from hiv, multiple sclerosis, epilepsy, hepatitis c ...201627270158
hiv transmission and injection drug use: lessons from the indiana outbreak.a recent outbreak of hiv infection centered in the rural town of austin in scott county, indiana, was associated with widespread injection drug use and a socio-economically depressed population. control of the outbreak required coordinated efforts by state, federal, local, and academic institutions to implement and maintain on-site programs and services that included contact tracing, hiv and hepatitis c virus testing, insurance enrollment, syringe exchange, rehabilitation services, care coordina ...201727841978
hcv screening in a cohort of hiv infected and uninfected homeless and marginally housed women in san francisco, california.hepatitis c virus (hcv) screening has taken on new importance as a result of updated guidelines and new curative therapies. relatively few studies have assessed hcv infection in homeless populations, and a minority include women. we assessed prevalence and correlates of hcv exposure in a cohort of homeless and unstably housed women in san francisco, and estimated the proportion undiagnosed.201728173785
mycobacterium tuberculosis infection among persons who inject drugs in san diego, california.persons who inject drugs (pwid) might be at increased risk for mycobacterium tuberculosis infection and reactivation of latent tuberculous infection (ltbi) due to their injection drug use.201728284258
the role of e-health in optimizing task-shifting in the delivery of antiviral therapy for chronic hepatitis c.recently, we reported the successful application of task-shifting to improve the management of patients with chronic hepatitis c virus (hcv) infection receiving treatment with direct-acting antiviral (daa) agents in underserved areas of california. we assessed the impact of e-health on task-shifting in our treatment model.201728375820
down in the valley: trajectories of injection initiation among young injectors in california's central valley.injection drug use initiation represents a critical point of public health intervention, as injection increases risk for blood borne infections including hepatitis c and hiv. in this paper, we explore pathways to injection initiation among youth (≤30) in the rural context of california's central valley, where rates of injection drug use are among the highest in the nation.201728458170
pharmacists performing hepatitis c antibody point-of-care screening in a community pharmacy: a pilot project.to describe the first community pharmacy-based hepatitis c antibody (hcv-ab) point-of-care (poc) screening program and its outcomes in california.201728602784
associations of criminal justice and substance use treatment involvement with hiv/hcv testing and the hiv treatment cascade among people who use drugs in oakland, california.people who smoke crack cocaine and people who inject drugs are at-risk for criminal justice involvement as well as hiv and hcv infection. compared to criminal justice involvement, substance use treatment (sut) can be cost-effective in reducing drug use and its associated health and social costs. we conducted a cross-sectional study of people who smoke crack cocaine and people who inject drugs to examine the association between incarceration, community supervision and substance use treatment with ...201728610602
hepatitis c virus prevalence in egyptian americans in southern california.hepatitis c virus (hcv) is a global medical health concern. egypt has the highest hcv prevalence. few studies have assessed the hcv prevalence rates among egyptian-born expatriates. we sought to define the hcv prevalence egyptian-born individuals residing in the southern california area.201728617761
cross-border injection drug use and hiv and hepatitis c virus seropositivity among people who inject drugs in san diego, california.the prevalence of hiv and hepatitis c virus (hcv) are significantly lower among people who inject drugs (pwid) in san diego, ca, usa compared with pwid in tijuana, mexico, located directly across the border. we investigated associations between cross-border injection drug use (idu), hiv and hcv seroprevalence and engagement in injecting risk behaviours while on each side of the border.201728683432
self-reported participation in voluntary nonprescription syringe sales in california's central valley.california senate bill 41 (sb41), effective january 2012, is a human immunodeficiency virus/hepatitis c virus prevention measure designed to expand syringe access among injection drug users (idus) by allowing pharmacies to sell syringes without a prescription. this study assesses self-reported implementation of sb41 and characterizes barriers amenable to intervention.201728807658
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