| the cathelicidin-derived tritrpticin enhances the efficacy of ertapenem in experimental rat models of septic shock. | sepsis remains a serious clinical problem despite intense efforts to improve survival. in this study, the efficacy of ertapenem combined with the cathelicidin tritrpticin was investigated in two rat models of septic shock. main outcome measures were bacterial growth in blood, peritoneum, spleen, liver, and mesenteric lymph nodes; endotoxin, interleukin 6, and tumor necrosis factor alpha concentrations in plasma; and lethality. adult male wistar rats were given (1) an intraperitoneal injection of ... | 2006 | 16878029 |