Publications

development of necator americanus in golden hamsters mesocricetus auratus.		1970	5501446
effect of cortisone upon serial passage with the human hookworm, necator americanus in golden hamsters, mesocricetus auratus.		1973	4752379
changes in carbohydrate metabolism in golden hamsters infected with necator americanus.		1982	7149838
[light and electron microscopic observations on effects of tribendimidin on cuticle of necator americanus and small intestinal mucosa of infected golden hamsters].	golden hamsters infected with necator americanus were treated orally with a new anthilmintic tribendimidin (n, n'-[bis-4'-(1-dimethyl amino ethylidene amino)phenyl] 1,4-phenyene dimethylidyne amine) at a single dose of 150 mg/kg. one h after medication, some worms showed cuticular swelling, fusion of transverse striations and attachment of host leucocytes onto the worm's damaged cuticular surface. four h post treatment, the cuticle revealed a moderate swelling or even erosion. meanwhile, the ven ...	1989	2816407
effect of albendazole on the larvae and eggs of necator americanus in golden hamster.	when golden hamsters infected with adult necator americanus were treated ig with albendazole(alb) 75 or 150 mg/kg, the efficacy rates were 83.8% and 100%, respectively. three days before treatment, the mean numbers of larvae recorded from the incubation of feces from 2 treated groups were 29,716 +/- 3,299 and 28,256 +/- 118 per gram of feces, while in the control group, it was 8,828 +/- 2,659. within 3 days after treatment, no larva was detected in the 2 treated groups, but in the control group ...	1994	7867156
necator americanus: maintenance through one hundred generations in golden hamsters (mesocricetus auratus). ii. morphological development of the adult and its comparison with humans.	through 100 passages, the human hookworm necator americanus was adapted to the golden hamster, mesocricetus auratus, without either the requirement for exogenous steroids or other immunosuppressive agents, nor the requirement to infect hamsters as pups. adult n. americanus recovered from infected hamsters were morphologically similar to those from infected humans in sichuan province, china, although they were smaller and the females produced fewer eggs. the natural history and kinetics of n. ame ...	2003	14990312
necator americanus: maintenance through one hundred generations in golden hamsters (mesocricetus auratus). i. host sex-associated differences in hookworm burden and fecundity.	the human hookworm necator americanus was maintained through one hundred generations in the golden hamster (mesocricetus auratus). the parasite strain employed here was ultimately adapted to hamsters without the requirement for exogenous steroids or other immunosuppressive agents. moreover, there was no requirement to use neonatal hamsters--successful infections were obtained in 9- to 10-week-old hamsters infected subcutaneously with 250 hookworm larvae. this unique adaptation of n. americanus t ...	2003	12932761
comparison of mitochondrial cytochrome oxidase 1 dna sequences from necator americanus hookworms maintained for 100 generations in golden hamsters (mesocricetus auratus) and hookworms from natural human infections.	the human hookworm necator americanus was maintained through one hundred generations in the golden hamsters. the strain is now routinely maintained in laboratory hamsters through serial passage, and is the laboratory strain of choice for vaccine studies. comparison of the mitochondrial cytochrome oxidase 1 (cox-1) sequences was shown previously to be useful for comparing the genetic structure of populations of n. americanus in china. cytochrome oxidase 1 genes were amplified by the polymerase ch ...	2004	15301977
necator americanus: optimization of the golden hamster model for testing anthelmintic drugs.	laboratory golden hamsters (mesocricetus auratus) were infected with necator americanus under several different parasite and host conditions to optimize the model for testing anthelminthic drugs. the results confirmed that male hamsters were more susceptible to infection than females. host age in the range of 5-15 weeks was not a factor that impacted on adult worm burden, and similar worm burdens were achieved using doses of 150, 250 or 500 n. americanus l3 (nal3). the largest numbers of adult h ...	2005	16198341
the evaluation of recombinant hookworm antigens as vaccines in hamsters (mesocricetus auratus) challenged with human hookworm, necator americanus.	we have previously reported the successful adaptation of human hookworm necator americanus in the golden hamster, mesocricetus auratus. this animal model was used to test a battery of hookworm (n. americanus and ancylostoma caninum) recombinant antigens as potential vaccine antigens. hamsters immunized a leading vaccine candidate n. americanus-ancylostoma secreted protein 2 (na-asp-2) and challenged with n. americanus infective larvae (l3), resulted in 30-46.2% worm reduction over the course of ...	2008	17645877
systems metabolic effects of a necator americanus infection in syrian hamster.	hookworms (ancylostoma duodenale and necator americanus) are blood-feeding intestinal nematodes that infect approximately 700 million people worldwide. to further our understanding of the systems metabolic response of the mammalian host to hookworm infection, we employed a metabolic profiling strategy involving the combination of (1)h nmr spectroscopic analysis of urine and serum and multivariate data analysis techniques to investigate the biochemical consequences of a n. americanus infection in ...	2009	19810771
the effect of tribendimidine and its metabolites against necator americanus in golden hamsters and nippostrongylus braziliensis in rats.	the antinematode effect of tribendimidine (tbd) and its metabolites has been studied. a total of 107 hamsters were each infected with 250 necator americanus third stage infective larvae (nal3) for 25 days. in the first test, 75 hamsters were divided equally into 15 groups for determination of ed(50) and ed(90.) among them, five groups were treated orally with tbd or its metabolite, p-(1-dimethylamino ethylimino)aniline (aminoamidine, deacylated amidantel, bay d 9216, dadt), at single doses of 1, ...	2010	20155372
Acquired hookworm immunity in the golden hamster (Mesocricetus auratus) elicited by living Necator americanus third-stage infective larvae.	The aim of the study is to demonstrate and understand the acquired immunity in golden hamsters (Mesocricetus auratus) elicited by primary Necator americanus infective third-stage larvae (L3) infection. Hamsters infected with 150 L3 for 1, 2, 3, 6 and 10weeks, were challenged with the same number of L3 and sacrificed 25days post challenge. The primarily infected hamsters exhibited 99-100% protection against subsequent L3 challenge compared to un-infected naive hamsters. The acquired immunity was ...	2012	22024448