Publications

analytical and clinical validation of novel real-time reverse transcriptase-polymerase chain reaction assays for the clinical detection of swine-origin h1n1 influenza viruses.	during the early stages of the 2009/2010 swine-origin h1n1 influenza a (s-oiv h1n1 flua) outbreak, the development and validation of sensitive and specific detection methods were a priority for rapid and accurate diagnosis. between may and june 2009, 2 real-time reverse transcriptase-polymerase chain reaction (rrt-pcr) assays targeting the hemagglutinin and neuraminidase genes of the s-oiv h1n1 flua virus were developed. these assays are highly specific, showing no cross-reactivity against a pan ...	2011	21251560
detection of resistance mutations to antivirals oseltamivir and zanamivir in avian influenza a viruses isolated from wild birds.	the neuraminidase (na) inhibitors oseltamivir and zanamivir are the first-line of defense against potentially fatal variants of influenza a pandemic strains. however, if resistant virus strains start to arise easily or at a high frequency, a new anti-influenza strategy will be necessary. this study aimed to investigate if and to what extent na inhibitor-resistant mutants exist in the wild population of influenza a viruses that inhabit wild birds. na sequences of all na subtypes available from 54 ...	2011	21253602
plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting h1n1 and h5n1 influenza.	in 2009, a novel h1n1 swine influenza virus was isolated from infected humans in mexico and the united states, and rapidly spread around the world. another virus, a highly pathogenic avian influenza virus of the h5n1 subtype, identified by the world health organization as a potential pandemic threat in 1997, continues to be a significant risk. while vaccination is the preferred strategy for the prevention and control of influenza infections, the traditional egg-based approach to producing influe ...	2011	21266846
acute necrotizing encephalopathy of childhood: a fatal complication of swine flu.	acute necrotizing encephalopathy of childhood (anec) is a rare condition characterized by the presence of multifocal symmetrical brain lesions involving mainly thalami, brainstem, cerebellum and white matter. anec is a serious and life threatening complication of simple viral infections. we present a case of a young child who developed this condition with classical clinical and radiological findings consistent with anec, secondary to swine flu (h1n1). he needed ventilatory support and had profou ...	2011	21333249
using electronic patient records to assess the impact of swine flu (influenza h1n1) on mental health patients.	electronic patient records are increasingly used in primary care research, but rarely in psychiatric research. little is known about how people with pre-existing mental illness respond to public health threats.	2011	21271827
determinants of adults' intention to vaccinate against pandemic swine flu.	vaccination is one of the cornerstones of controlling an influenza pandemic. to optimise vaccination rates in the general population, ways of identifying determinants that influence decisions to have or not to have a vaccination need to be understood. therefore, this study aimed to predict intention to have a swine influenza vaccination in an adult population in the uk. an extension of the theory of planned behaviour provided the theoretical framework for the study.	2011	21211000
swine outbreak of pandemic influenza a virus on a canadian research farm supports human-to-swine transmission.	swine outbreaks of pandemic influenza a (ph1n1) suggest human introduction of the virus into herds. this study investigates a ph1n1 outbreak occurring on a swine research farm with 37 humans and 1300 swine in alberta, canada, from 12 june through 4 july 2009.	2011	21148514
editorial commentary: the problem with pigs: it's not about bacon.		2011	21148515
potent inhibitor design against h1n1 swine influenza: structure-based and molecular dynamics analysis for m2 inhibitors from traditional chinese medicine database.	the rapid spread of influenza virus subtype h1n1 poses a great threat to million lives worldwide. to search for new anti-influenza compounds, we performed molecular docking and molecular dynamics simulation to identify potential traditional chinese medicine (tcm) constituents that could block influenza m2 channel activity. quinic acid, genipin, syringic acid, cucurbitine, fagarine, and methyl isoferulate all have extremely well docking results as compared to control amantadine. further de novo d ...	2011	21142218
development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza a virus h1n1.	since its emergence in april 2009, pandemic influenza a virus h1n1 (h1n1 pdm), a new type of influenza a virus with a triple-reassortant genome, has spread throughout the world. initial attempts to diagnose the infection in patients using immunochromatography (ic) relied on test kits developed for seasonal influenza a and b viruses, many of which proved significantly less sensitive to h1n1 pdm. here, we prepared monoclonal antibodies that react with h1n1 pdm but not seasonal influenza a (h1n1 an ...	2011	21228147
the nonadaptive nature of the h1n1 2009 swine flu pandemic contrasts with the adaptive facilitation of transmission to a new host.	the emergence of the 2009 h1n1 influenza pandemic followed a multiple reassortment event from viruses originally circulating in swines and humans, but the adaptive nature of this emergence is poorly understood.	2011	21211019
pandemic h1n1 influenza virus causes a stronger inflammatory response than seasonal h1n1 influenza virus in ferrets.	a 2009 h1n1 influenza virus pandemic, which had its origin in swine, caused severe illness and mortality in humans. inflammatory responses may be responsible for pathogenesis caused by infection with influenza viruses. to better understand the pathogenic mechanism, clinical signs and inflammatory responses in ferrets infected with the pandemic h1n1 were compared with those caused by seasonal h1n1 influenza virus. ferrets infected with the 2009 pandemic h1n1 virus displayed higher body temperatur ...	2011	21234768
possible reason for cross-species and cross-subtype reassortment in polymerase basic protein 2 from influenza a virus.	the reassortment in proteins from influenza a viruses among human, swine, and eurasian avian strains formed a new influenza a virus leading to the first pandemic in this century, which suggests that the barrier between species and between subtypes would not be strong enough to prevent the cross-species infection and cross-subtype reassortment from occurring. in this study, we intensively used the anova including its model i and model ii to analyze 2430 polymerase basic proteins 2 (pb2) of influe ...	2011	21171947
comparison of two h1n2 swine influenza a viruses from disease outbreaks in pigs in sweden during 2009 and 2010.	the influenza a virus subtypes h1n1, h1n2 and h3n2 are prevalent in pig populations worldwide. in the present study, two relatively uncommon swine influenza virus (siv) h1n2 subtypes, isolated in sweden in 2009 and 2010, were compared regarding their molecular composition and biological characteristics. the differences regarding markers purportedly related to pathogenicity, host adaptation or replication efficiency. they included a truncated pb1-f2 protein in the earlier isolate but a full lengt ...	2011	21253862
organizing pneumonia associated with swine-origin influenza a h1n1 2009 viral infection.		2011	21178022
pandemic h1n1 2009 ('swine flu'): diagnostic and other challenges.	pandemic h1n1 2009 ('swine flu') virus was 'the virus of the year 2009' because it affected the lives of many people in this year. h1n1 was first described in california in april 2009 and spread very rapidly all over the globe. the fast global penetration of the swine flu caused the who in geneva to call the infection with h1n1 a new pandemic with a rapid escalation of the different pandemic phases that ended on 11 june 2009, with the declaration of phase 6 (full-blown pandemic). this had far-re ...	2011	21171919
seroprevalence and genetic characteristics of five subtypes of influenza a viruses in the chinese pig population: a pooled data analysis.	a literature review and pooled data analysis were carried out to examine the prevalence of antibodies against five influenza virus subtypes in pigs in china over a 10-year period (1999-2009). the average seropositive frequencies of subtypes h1, h3, h5, h7 and h9 were 3478/11,168 (31.1%), 2900/10,139 (28.6%), 77/5945 (1.3%), 0/1440 (0%) and 86/3619 (2.4%), respectively. there was a geographical variation in the seroprevalence of subtype h1, with the highest seroprevalence in pigs in south and eas ...	2011	19945318
virological surveillance and preliminary antigenic characterization of influenza viruses in pigs in five european countries from 2006 to 2008.	this study presents the results of the virological surveillance for swine influenza viruses (sivs) in belgium, uk, italy, france and spain from 2006 to 2008. our major aims were to clarify the occurrence of the three siv subtypes - h1n1, h3n2 and h1n2 - at regional levels, to identify novel reassortant viruses and to antigenically compare sivs with human h1n1 and h3n2 influenza viruses. lung tissue and/or nasal swabs from outbreaks of acute respiratory disease in pigs were investigated by virus ...	2011	20042068
cytokines and acute phase proteins associated with acute swine influenza infection in pigs.	this study set out to investigate the cytokines and acute phase proteins (apps) associated with the acute stages of experimentally-induced swine influenza virus (siv) infection in 3-week-old, colostrum-deprived, caesarean-derived piglets. the piglets were inoculated intratracheally with 10(7.5) 50% egg infective dose [eid(50)] swine/belgium/1/98 (h1n1) siv and were euthanased at time-points between 0 and 120h post-inoculation (pi). broncho-alveolar lavage fluid (balf), lung homogenates and sera ...	2011	20097110
initial psychological responses to swine flu.	the emergence of influenza a ("swine flu") in early 2009 led to widespread public concern. however, little research has examined the factors that underlie initial worry about infection and subsequent behavioral responses to such worry.	2011	20195809
swine influenza and cytokines: less of a storm, more of a breeze.		2011	20434376
the use of high-frequency oscillatory ventilation in a patient with h1n1 pneumonia.	a 32-year-old multigravida was admitted at 33.9 weeks with respiratory distress. community-acquired pneumonia was suspected and antimicrobial treatment initiated with ceftriaxone sodium and azithromycin. however, despite these therapies her respiratory status deteriorated. she was subsequently diagnosed with swine-origin influenza a (h1n1) virus pneumonia and treated with oseltamivir. after failing conventional ventilation, high-frequency oscillatory ventilation (hfov) was utilized. in pregnant ...	2011	20476871
national swine flu adult assessment guidelines: retrospective validation of objective criteria in three proxy datasets.	to validate the objective criteria in the department of health adult swine flu assessment tool against proxy datasets for pandemic influenza.	2011	20581387
reconstructing disease outbreaks from genetic data: a graph approach.	epidemiology and public health planning will increasingly rely on the analysis of genetic sequence data. in particular, genetic data coupled with dates and locations of sampled isolates can be used to reconstruct the spatiotemporal dynamics of pathogens during outbreaks. thus far, phylogenetic methods have been used to tackle this issue. although these approaches have proved useful for informing on the spread of pathogens, they do not aim at directly reconstructing the underlying transmission tr ...	2011	20551981
influenza a (h1n1) virus-induced hepatocellular injury in a kidney transplant patient.	the swine-origin influenza a (h1n1) virus is mainly responsible for flu. no hepatitis attributable to h1n1 virus has been previously documented. herein, we report on a kidney transplant patient who developed influenza h1n1 virus-induced hepatocellular injury. the patient's body temperature was only somewhat elevated, and pulmonary and flu symptoms were mild. h1n1 virus was detected by polymerase chain reaction assay in nasopharyngeal and bronchoalveolar swabs, as well as in the serum. the hepato ...	2011	20649943
modelling the transmission dynamics and control of the novel 2009 swine influenza (h1n1) pandemic.	the paper presents a deterministic compartmental model for the transmission dynamics of swine influenza (h1n1) pandemic in a population in the presence of an imperfect vaccine and use of drug therapy for confirmed cases. rigorous analysis of the model, which stratifies the infected population in terms of their risk of developing severe illness, reveals that it exhibits a vaccine-induced backward bifurcation when the associated reproduction number is less than unity. the epidemiological consequen ...	2011	20379852
acute myelopathy associated with h1n1 virus infection.	the swine-origin influenza a (h1n1) virus caused a pandemic infection in june 2009. the incidence of neurological complications due to h1n1 virus infection is unknown. two cases of cervical acute myelopathy associated with h1n1 virus infection are reported. both patients (male 29 years and female 24 years) suffered moderate to severe sensory and motor symptoms, but recovered completely within a few weeks. acute myelopathy is a rare complication of h1n1 infection, but appears to be of similar cou ...	2011	20652296
resistance characteristics of influenza to amino-adamantyls.	the recent outbreaks of avian flu in southeast asia and swine flu in mexico city painfully exemplify the ability of the influenza virus to rapidly mutate and develop resistance to modern medicines. this review seeks to detail the molecular mechanism by which the influenza virus has obtained resistance to amino-adamantyls, one of only two classes of drugs that combat the flu. amino-adamantyls target the viral m2 h(+) channel and have become largely ineffective due to mutations in the transmembran ...	2011	20599692
isolation and genetic analysis of a novel triple-reassortant h1n1 influenza virus from a pig in china.	influenza a viruses of subtype h1n1 have been reported widely in pigs in china, associated with clinical disease. these mainly include classical swine h1n1, avian-like h1n1, and human-like h1n1 viruses. in this study, we reported a novel triple-reassortant h1n1 virus (a/swine/guangdong/1/2010) containing genes from the classical swine (np, ns), human (pb1) and avian (ha, na, m, pb2, pa) lineages, which was for the first time reported in china. also, phylogenetic analysis further confirmed that f ...	2011	20708352
clinical outcomes of pandemic (h1n1) 2009 influenza (swine flu) in adults with cystic fibrosis.		2011	20820065
simultaneous molecular detection and confirmation of influenza ah5, with internal control.	influenza viruses continue to be a major cause of respiratory tract infection, resulting in substantial morbidity and mortality throughout the world. accurate and rapid differential diagnosis of influenza virus infections, particularly associated with zoonotic infections, is important for public health actions, patient management, and treatment. real-time pcr is widely considered the gold standard for molecular detection of influenza viruses owing to its high assay specificity, extreme detection ...	2011	21116801
h1n1: viral pneumonia as a cause of acute respiratory distress syndrome.	to review the literature on novel swine origin influenza a (h1n1 2009) as a cause of respiratory failure and acute respiratory distress syndrome (ards).	2011	21157318
swine influenza a (h1n1) virus infection in infants.	there are few reports on pandemic swine influenza a (h1n1) virus infection in very young infants. we aimed to discuss the clinical characteristics and management of the h1n1 influenza infection in very young infants. clinical characteristics of ten infants diagnosed with h1n1 influenza virus infection during the 2009 outbreak season in a tertiary neonatal intensive care unit were evaluated. the diagnosis was confirmed by testing of respiratory samples with pandemic h1n1 influenza specific real-t ...	2011	20857145
how should we best manage patients with immune-mediated inflammatory disease on immunosuppressant therapy during the 'swine flu' pandemic?		2011	20843774
one-step multiplex reverse-transcriptase pcr for detecting pandemic (h1n1) 2009 influenza virus.	pandemic (h1n1) 2009 influenza has spread throughout the world since april 2009 and has caused many human deaths since its first report in humans. pandemic (h1n1) 2009 influenza virus was first identified in a canadian pig herd in april 2009 and has been reported in more than ten countries, including korea. we developed a one-step multiplex reverse transcriptase polymerase chain reaction (rt-pcr) assay based on the matrix gene that discriminates pandemic (h1n1) 2009 influenza virus from endemic ...	2011	20798477
human parainfluenza virus type 3 (hpiv 3) viral community-acquired pneumonia (cap) mimicking swine influenza (h1n1) during the swine flu pandemic.	the swine influenza (h1n1) pandemic began in mexico in 2009 and quickly spread worldwide. during the h1n1 pandemic, many patients were admitted to the winthrop-university hospital with influenza-like illnesses (ilis). many hospitalized adults had h1n1 pneumonia diagnosed by laboratory or clinical criteria. however, the laboratory diagnosis of h1n1 was problematic. the rapid influenza (quickvue a/b [quidel, san diego, ca]) test frequently showed false-negative results. reverse transcriptase-polym ...	2011	20888645
quantitative analysis of influenza m2 channel blockers.	the influenza m2 h(+) channel enables the concomitant acidification of the viral lumen upon endosomic internalization. this process is critical to the viral infectivity cycle, demonstrated by the fact that m2 is one of only two targets for anti-flu agents. however, aminoadamantyls that block the m2 channel are of limited therapeutic use due to the emergence of resistance mutations in the protein. herein, using an assay that involves expression of the protein in escherichia coli with resultant gr ...	2011	20831860
the new influenza a (h1n1/09): symptoms, diagnostics, and autopsy results.	the first infections of the new h1n1 ("swine flu") virus were announced in april 2009. soon after, case numbers were observed to be climbing virtually worldwide. in most cases, infections appeared rather mild with typical flu symptoms. in contrast to the seasonal flu, however, cases with vomiting and diarrhea were also reported, and the affected age group seemed to be younger. sudden and fatal progression affected mostly those under 60 years of age. the autopsy reports of two fatalities with the ...	2011	20734056
Genetic analysis and antigenic characterization of swine origin influenza viruses isolated from humans in the United States, 1990-2010.	Swine influenza viruses (SIV) have been recognized as important pathogens for pigs and occasional human infections with swine origin influenza viruses (SOIV) have been reported. Between1990 and 2010, a total of twenty seven human cases of SOIV infections have been identified in the United States. Six viruses isolated from1990 to 1995 were recognized as classical SOIV (cSOIV) A(H1N1). After 1998, twenty-one SOIV recovered from human cases were characterized as triple reassortant (tr_SOIV) inherit ...	2012	22078166
contemporary epidemiology of north american lineage triple reassortant influenza a viruses in pigs.	the 2009 pandemic h1n1 infection in humans has been one of the greatest concerns for public health in recent years. however, influenza in pigs is a zoonotic viral disease well-known to virologists for almost one century with the classical h1n1 subtype the only responsible agent for swine influenza in the united states for many decades. swine influenza was first recognized clinically in pigs in the midwestern u.s. in 1918 and since that time it has remained important to the swine industry through ...	2012	22266673
complicated secondary pneumonia after swine-origin influenza a virus infection in an immunocompetent patient.	the pandemic of the swine-origin influenza a virus (s-oiv) in 2009 demonstrated severe viral pneumonia followed by acute respiratory distress syndrome (ards). although ards would be caused by the influenza virus pneumonia itself, it has remained unclear whether other respiratory viral or bacterial infections coexist with s-oiv pneumonia. we report an immunocompetent patient with methicillin-resistant staphylococcus aureus (mrsa) and herpes simplex virus (hsv) pneumonia secondary to s-oiv infec ...	2012	22251837
[serological detection of emerging viral infections in wild boars from different hunting regions of southern germany].	wild boars represent a possible virus reservoir for notifiable diseases of farm animals, including aujeszky's disease (ad) and classical swine fever (csf). monitoring of the epidemiological situation in the wild boar population is especially relevant in countries that are officially free from these diseases. apart from oie-notifiable diseases, other viral agents that are widely distributed and play a significant role in farm animals, such as the porcine reproductive and respiratory syndrome viru ...	2012	22331288
prevalence of and risk factors associated with viral and bacterial pathogens in farmed european wild boar.	the aim of this study was to estimate in farmed european wild boars the prevalence of and risk factors associated with a range of common porcine viral and bacterial infections, namely, porcine parvovirus (ppv), porcine circovirus type 2 (pcv2), swine influenza virus (siv), aujeszky's disease virus (adv), classical swine fever virus (csfv), swine vesicular disease virus (svdv), coronavirus causing transmissible gastroenteritis (tgev), porcine reproductive and respiratory syndrome virus (prrsv), m ...	2012	22516920
Reassortment Networks and the evolution of pandemic H1N1 swine-origin influenza.	Prior research developed Reassortment Networks to reconstruct the evolution of segmented viruses under both reassortment and mutation. We report their application to the swine-origin pandemic H1N1 virus (S-OIV). A database of all influenza A viruses, for which complete genome sequences were available in Genbank by October 2009, was created and dynamic programming was used to compute distances between all corresponding segments. A reassortment network was created to obtain the minimum cost evolut ...	2012	22076498
prevalence of antibodies to selected viral pathogens in wild boars (sus scrofa) in croatia in 2005-06 and 2009-10.	we determined prevalence of antibody to selected viral pathogens important for domestic pigs and livestock in 556 wild boar (sus scrofa) sera collected during 2005-06 and 2009-10 in four counties in croatia. these counties account for an important part of the croatian commercial pig production and have a high density of wild boars. samples were tested for antibodies to porcine parvovirus (ppv), aujeszky's disease virus (adv), porcine circovirus type 2 (pcv2), swine influenza virus, porcine respi ...	2012	22247381
evaluation of three commercially available influenza a type-specific blocking-elisa assays for seroepidemiological studies of influenza a virus infection in pigs.	the reverse zoonotic transmission of the pandemic h1n1 2009 virus to swine necessitates enhanced surveillance of swine for influenza virus infection. using a well characterized panel of naturally infected swine sera we evaluate and optimize the performance of three commercially available competitive elisa assays, idexx® influenza a ab test, idexx® ai multis-screen ab test and idvet id screen® influenza a antibody competition elisa kit for detecting influenza type a reactive antibodies in swine. ...	2012	22219314
epidemiological survey of swine influenza a virus in the wild boar population of two italian provinces.	an epidemiological survey was carried out in order to obtain a better understanding of the role of wild boars in the epidemiology of the influenza virus.	2013	24224815
genomic analysis of influenza a virus from captive wild boars in brazil reveals a human-like h1n2 influenza virus.	influenza is a viral disease that affects human and several animal species. in brazil, h1n1, h3n2 and 2009 pandemic h1n1 a(h1n1)pdm09 influenza a viruses (iav) circulate in domestic swine herds. wild boars are also susceptible to iav infection but in brazil until this moment there are no reports of iav infection in wild boars or in captive wild boars populations. herein the occurrence of iav in captive wild boars with the presence of lung consolidation lesions during slaughter was investigated. ...	2014	24238665
severity of bovine tuberculosis is associated with co-infection with common pathogens in wild boar.	co-infections with parasites or viruses drive tuberculosis dynamics in humans, but little is known about their effects in other non-human hosts. this work aims to investigate the relationship between mycobacterium bovis infection and other pathogens in wild boar (sus scrofa), a recognized reservoir of bovine tuberculosis (btb) in mediterranean ecosystems. for this purpose, it has been assessed whether contacts with common concomitant pathogens are associated with the development of severe btb le ...	2014	25350002
serological evidence for influenza virus infection in korean wild boars.	serum samples from 1,011 wild boars hunted in 2012 were collected for serological surveillance for 4 subtypes (pandemic a (h1n1) 2009 and classical h1n1, h1n2 and h3n2) of swine influenza virus (siv). samples from 12 of the boars were identified as positive for siv (pandemic a (h1n1) 2009, n=9; classical h1n1, n=2; and h1n2, n=1) by a hemagglutination inhibition test (hi test) and a nucleoprotein (np)-based enzyme-linked immunosorbent assay (np-elisa). although the overall seroprevalence of siv ...	2014	25298239
a serosurvey for selected pathogens in greek european wild boar.	serum samples, collected from 94 european wild boar (sus scrofa) during the hunting seasons 2006 -2010 from different regions of greece, were examined in order to estimate the role of these wildlife species as reservoir of pathogens important for livestock and/or public health.	2015	26392908
multiplex serology for common viral infections in feral pigs (sus scrofa) in hawaii between 2007 and 2010.	multiplex serology was performed for the detection of total immunoglobulin (ig) and igm antibodies against porcine circovirus type 2 (pcv2), porcine reproductive and respiratory syndrome virus (prrsv), and swine influenza virus (siv) antigens in feral swine (sus scrofa). serum samples were collected from the islands of oahu (292 pigs) and hawaii (52 pigs) between 2007 and 2010. the highest antibody prevalence was to pcv2 (63%), followed by siv (7.8%) and prrsv (5.8%). antigen-specific igm was de ...	2015	25380357
serological survey of avian influenza virus infection in non-avian wildlife in xinjiang, china.	we conducted a serological survey to detect antibodies against avian influenza virus (aiv) in gazella subgutturosa, canis lupus, capreolus pygargus, sus scrofa, cervus elaphus, capra ibex, ovis ammon, bos grunniens and pseudois nayaur in xinjiang, china. two hundred forty-six sera collected from 2009 to 2013 were assayed for antibodies against h5, h7 and h9 aivs using hemagglutination inhibition (hi) tests and a pan-influenza competitive elisa. across all tested wildlife species, 4.47 % harbored ...	2016	26733295
polymorphism and peptide-binding specificities of porcine major histocompatibility complex (mhc) class i molecules.	the swine lymphocyte antigen class i (sla i) is a highly polymorphic gene superfamily that plays an important role in swine anti-viral immune responses. however, an understanding of the highly variable sites and peptide-binding specificities of sla i molecule is limited. in this study, a total of 27 sla i alleles were identified from 3 tibetan wild boars and 3 heishan pigs. the phylogenetic relationship between the tibetan wild boar and other breeds was analyzed using bioinformatics methods, and ...	2017	28751109
global mammal parasite database version 2.0.	illuminating the ecological and evolutionary dynamics of parasites is one of the most pressing issues facing modern science, and is critical for basic science, the global economy, and human health. extremely important to this effort are data on the disease-causing organisms of wild animal hosts (including viruses, bacteria, protozoa, helminths, arthropods, and fungi). here we present an updated version of the global mammal parasite database, a database of the parasites of wild ungulates (artioda ...	2017	28273333
antibodies to various zoonotic pathogens detected in feral swine (sus scrofa) at abattoirs in texas, usa.	the zoonotic risk posed to employees by slaughtering feral swine (sus scrofa) at two abattoirs in texas was assessed by testing feral swine serum samples for exposure to influenza a virus, leptospira, trichinella spiralis, and toxoplasma gondii. blood was collected from a total of 376 feral swine between the two facilities during six separate collection periods in 2015. antibodies to one or more serovars of leptospira were identified in 48.9% of feral swine tested, with bratislava and pomona as ...	2017	28686494
survey for selected pathogens in wild pigs (sus scrofa) from guam, marianna islands, usa.	pigs (sus scrofa) were introduced to guam in the 1600's and are now present in high densities throughout the island. wild pigs are reservoirs for pathogens of concern to domestic animals and humans. exposure to porcine parvovirus, transmissible gastroenteritis, and leptospira interrogans has been documented in domestic swine but data from wild pigs are lacking. the close proximity of humans, domestic animals, and wild pigs, combined with the liberal hunting of wild pigs, results in frequent oppo ...	2017	28622856
host and viral traits predict zoonotic spillover from mammals.	the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ...	2017	28636590
sus scrofa mir-204 and mir-4331 negatively regulate swine h1n1/2009 influenza a virus replication by targeting viral ha and ns, respectively.	the prevalence of swine pandemic h1n1/2009 influenza a virus (siv-h1n1/2009) in pigs has the potential to generate novel reassortant viruses, posing a great threat to human health. cellular micrornas (mirnas) have been proven as promising small molecules for regulating influenza a virus replication by directly targeting viral genomic rna. in this study, we predicted potential sus scrofa (ssc-, swine) mirnas targeting the genomic rna of siv-h1n1/2009 by regrna 2.0, and identified ssc-mir-204 and ...	2017	28368362
influenza a virus infection in japanese wild boars (sus scrofa leucomystax).	serum samples were collected from 385 wild boars between 2010 and 2013 to examine the seroprevalence of influenza a virus (iav) in japan. antibodies against iav were identified using a commercial kit in 13 wild boars (3.4%). to identify the serotypes, positive sera were examined by virus-neutralization test using representative serotypes and strains. three wild boars in yamaguchi and four in tochigi showed the highest antibody titers against the pandemic h1n1 2009 virus and classical swine h1n1 ...	2017	28321029