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new polymorphism of the influenza virus resistance mx1 gene in iberian domestic pigs.mx1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78) gene has been implicated in the resistance to a wide range of rna viruses including influenza a in several species such as sus scrofa. in the present study a 28-bp deletion in exon 14 of the mx1 gene has been identified in iberian domestic pigs but not in other domestic breeds neither in wild boars. the mutation produces a frameshift giving a protein with 6 amino acid substitutions and the extension of the c-termina ...027774491
neutralizing antibodies in human serum after influenza a : the lack of strain specificity in the immunological response.the increased concentrations of neutralizing antibodies against influenza a virus in human serum which occur after influenza a do not differentiate between antigenically different strains of this virus or swine influenza virus but instead appear to possess equal reactivity against these agents. the decrease in antibody levels which occurs with time is also independent of the strain of virus used to measure it.194119871146
inhibition by egg-white of hemagglutination by swine influenza virus. 194818869331
[common antigenic components in serological subtypes of influenza a virus]. 19666002462
a new influenza a virus infection in turkeys. vii. comparative immunology.four influenza a strains isolated from turkeys in ontario as well as strain chicken/scotland/59 were found to immunize turkeys against the lethal disease caused by virus turkey/ontario 7732/66 (v7732). these viruses form the avian influenza a serotype 5 (aa5). immunoprotection against v7732 was not obtained with influenza viruses of other serotypes. immunoprotective relationships among aa5 viruses were not always demonstrable in hemagglutination-inhibition (hi) and serum-neutralization (sn) test ...19714251414
the "in vivo" production of "new" influenza a viruses. i. genetic recombination between avian and mammalian influenza viruses. 19715565817
relationship between human and animal infections with a2 /hong kong/68 - like strains of influenza virus. 19724681052
[hypotheses and facts on the origin of pandemic strains of influenza a virus]. 19751121849
[a sero-epizootical survey on hong-kong type influenza among pigs in japan (author's transl)]. 19751241632
antiviral, immunosuppressive and antitumour effects of ribavirin. 19761256547
antigenicity of inactivated swine influenza virus concentrated by centrifugation.swine influenza virus grown in fertile chicken eggs was inactivated with a 1:4000 dilution of formalin for three days. centrifugation at 47,000 g for 1-3 hours concentrated the viral particles. reconstitution to 1/10 the original volume for use as a vaccine resulted in a product having an ha titer of 1:64 to 1:512. two doses of 4 ml given three weeks apart resulted in a serologic response in three of six gilts of breeding age. experimental challenge of two vaccinated and two control gilts to swi ...19761257594
letter: vaccine against swine influenza. 19761276748
[the possible epidemic recrudescence of swine-like influenza virus type a].an account of the effects of recent influenza epidemics is given from the medical standpoint, and also with respect to their social and economic repercussions. the part played by air travel in the carriage of such epidemics is also examined. the immunity of the population of rome towards an a strain swine fever (a/new jersey 8/76) is assessed in the light of personal research.1976995280
antibodies to influenza a/swine-like viruses (hsw1n1) in human sera: antigenic stimulation and changes in antibody status.human sera collected at the end of 1975 were studied for hi antibodies to influenza a/mayo clinic/103/74 (hsw1n1). the frequent occurrence of these antibodies in subjects born before 1930 suggested that they are present in about 25% of the finnish population. during the h3n2 epidemic in winter 1975-76 a low response of antibodies to a/swine-like viruses was recorded in about half of the influenza patients with a pre-existing titre, but not in any of the patients without pre-existing antibodies. ...1976998257
[prevalence of antibodies to a/new jersey/76, a/victoria/3/75 and b/hong kong/5/72 influenza viruses in the population of milan examined in the late spring of 1976 and evaluation of the past experience of the same population with probable agent of the 1918-20 pandemics].hemagglutination inhibiting antibodies (h.i.a.) to influenza viruses a/new jersey/76, a/victoria/3/75 and b/hong kong/5/72 were titrated in 227 serum samples collected in milan in the late spring 1976 from healthy subjects of 0 to 90 years of age. in 185 of these neuraminidase-inhibiting antibodies (n.i.a.) for the type a strains were also titrated. subjects up to 40 years of age lack h.i.a. to a/new jersey/76 strain; antibody levels equal to or greater than 1:40 are occasionally present in the ...19761016579
[possible significance of human patients with "swine" influenza virus in january-february,1976 at fort dix, new jersey, usa, and theories concerning the cause of deaths in the influenza pandemic of 1918-1919]. 19761024248
swine flu: did uncle sam buy a pig in a poke? 19761027540
the swine flu immunization program. 19761028314
swine influenza virus in man. zoonosis or human pandemic? 197659086
swine influenza virus and the recycling of influenza-a viruses in man.sera collected in 1967 and 1972 from people in the 0-100 age-group showed haemagglutination-inhibition (h.i.) antibody to swine virus a/iowa/15/30 (hsw1n1) in greatest number and with highest titre in people born before 1918. a slight decrease was observed from 1967 to 1972 in the number of sera with antibody to swine virus and in the height of the titres. the recently isolated a/new jersey/10/76 (hsw1n1) virus showed a result comparable to that of the swine/1930 virus in sera of 1972. on the an ...197659252
the epidemiology of influenza.although unpredictable, influenza outbreaks are known to occur in three patterns: pandemics every 30 to 40 years, with high excess mortality; epidemics much more frequently, with lower excess mortality; and usually mild sporadic outbreaks. the possibility of a swine-flu pandemic this winter, resembling that of 1918-20, is the result of a unique deviation in the epidemiology of this fascinating disease.197667988
evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections.the potential antiviral activity of 6-azauridine and 5-iododeoxyuridine was evaluated in a coordinated study at five institutions. experimental models in five species, the mouse, rabbit, swine, cat, and ferret, were established with use of 10 viruses: herpesvirus hominis types 1 and 2, murine cytomegalovirus, vaccinia virus, shope fibroma virus, transmissible gastroenteritis virus, swine influenza virus, feline viral rhinotracheitis virus, feline panleukopenia virus, and ferret distemper virus. ...1976180189
influenza: its antigenic variation and ecology.influenza viruses have two surface antigens, the glycoprotein structures hemagglutinin (ha) and neuraminidase (na). antibodies to each of these are associated with immunity, but the structures themselves are antigenically variable. when an antigenic change is gradual over time it is referred to as a drift, while a sudden complete or major change in either or both antigens is termed a shift. the mechanism of antigenic drift is usually attributed to selection of preexisting mutants by pressure fro ...1976187273
swine influenza: history and recommendations for vaccination. 1976792372
swine flu: play it again, uncle sam. 1976800413
the swine-influenza decision.we analyzed the economic aspects of mass immunization against swine-like influenza in 1976-1977, and have used the delphi technic for estimating the likelihood and characteristics of an epidemic. if an epidemic occurs and no preventive efforts are made, total costs could exceed $6 billion for the whole population and $3 billion for those in the high-risk group. expected net benefits from immunization vary with (1) the target population, (2) costs of vaccine administration and (3) vaccine accepta ...1976822331
the swine-influenza decision. 1977830271
[swine influenza]. 1977835180
a surveillance of human influenza virus in swine in southern taiwan.from september 1970 to december 1971, samples were taken monthly from farm pigs, piglets and abattoir pigs in southern taiwan for virus isolations and serologic studies. a total of 10 strains of hemagglutinating agent were isolated in january and july 1971, following 2 epidemics of human influenza occurring in december 1970 and june 1971, respectively. three strains were antigenically confirmed as influenza a similar to a/hong kong/68 virus.1977885670
sensitivity of influenza a/new jersey/8/76 (hsw1n1) virus to amantadine-hcl.the appearance of a swine type of influenza a among recruits in fort dix, new jersey, in 1976 prompted an evaluation of the sensitivity of this virus to amantadine - hcl. well-tolerated levels of the drug effectively blocked replication of the influenza a/new jersey/8/76 (hsw1n1) virus isolate in three laboratory models: monkey kidney cells, embryonated eggs, and intranasally infected mice. on a comparative basis this virus would appear to be more sensitive to amantadine - hcl than human influen ...1977894080
local immunity in the pig respiratory tract. ii. -- relationship of serum and local antibodies.antibody passage from blood to respiratory secretions was studied on pigs. the animals were passively immunized and have a high anti-hog cholera serum antibody titer. with normal animals as with swine influenza animals, no serum antibody could be recovered neither in buccopharyngeal secretions nor in lung washings: it seems that in such conditions no detectable transudation occurs from blood to local secretions. following intranasal inoculation of swine influenza virus or intramuscular injection ...1977907266
local immunity in the pig respiratory tract. i. -- cellular and humoral immune responses following swine influenza infection.by serial lung washings on living pigs, kinetics of humoral and cellular local immune responses have been studied following intranasal inoculation of swine influenza virus. local and serum antibodies appeared 8 days post-infection (p.i.) and reached a maximal titer 2 weeks p.i. antibody titer decreased faster in lung secretions than in serum. local and systemic cell-mediated immune responses were detected, by in vitro transformation tests, during the second week p.i.1977907269
isolation of wine influenza virus in oklahoma.three isolations of swine influenca virus were made from 2 swine herds in west-central oklahoma. many swine in these herds had signs of respiratory tract disease, and in 1 herd, some affected animals also had diarrhea. two isolations were made in swine testicle cell line and 1 in embryonating chicken eggs. all 3 strains were cytopathogenic for swine testicle cells.1977924848
antibody formation in laboratory animals after parenteral application of a/swine influenza virus.antigenicity of swine influenza viruses, ann arbor/31 and recombinant x-53, was compared on the different animal species. the serological investigations of animals infected with live or immunized with the inactivated virus, demonstrated a close antigenic relationship between the h and n antigens of both viruses. for inactivated vaccine preparation it was recommended, on the basis of our results, to use ann arbor virus instead of virus x-53.1977604122
polyacrylamide gel electrophoresis of the rnas of new influenza virus strains: an epidemiological tool.recently, we have shown by separating the rnas and proteins of different influenza a viruses on polyacrylamide gels, that influenza a viruses contain 8 genes corresponding to 8 virus specific proteins. by analyzing the rna patterns and the protein patterns of different recombinant viruses we, subsequently, succeeded in establishing a complete genetic map for influenza a viruses. these techniques were extended to characterize the genome of new influenza virus isolates. thus it was found that the ...1977604123
antigenic subgroups of influenza a (hsw1 n1) virus differentiated by hemagglutination inhibition.eleven influenza a/swine virus strains could be arranged in three subgroups by hemagglutination inhibition (hi) titrations. the antisera used include post-infection ferret sera (native as well as after adsorption with heterologous hsw1 n1 virus) and paired human sera from recent influenza a patients, showing antibody titre rises against a/swine virus. for serological detection of infections with an unknown a/swine virus, virus strains of the subgroup with the broadest reactivity are more suitabl ...1977604129
identification and preliminary antigenic analysis of swine influenza-like viruses isolated during an influenza outbreak at fort dix, new jersey.the sequence of events and the laboratory procedures that resulted in the identification of swine influenza-like viruses isolated during an influenza outbreak at fort dix, new jersey in january and february of 1976 are described. preliminary antigenic analysis suggested that the isolates from fort dix are closely related to a 1975 isolate of swine influenza virus and distinguishable from earlier swine influenza strains.1977606762
ether-treated, subunit hsw1n1 influenza vaccines: response of immunologically primed subjects to two antigenic variants.two bivalent, ether-treated, subunit influenza vaccines were compared in adults greater than or equal to 45 years old. both vaccines contained 200 chick cell-agglutinating (cca) units of a/victoria/3/75 antigen/dose. the hsw1n1 components, also at a level of 200 cca units/dose and designated a/shope and a/x-53, were antigenically representative of the a/swine/1976/31 and a/new jersey/8/76 viruses, respectively. a/shope virus possessed about 100 times more neuraminidase activity than a/x-53 virus ...1977606773
infection and vaccination of pigs with influenza a/new jersey/8/76 (hsw1n1) virus.pigs were infected and had mild signs of illness when exposed to influenza a/new jersey/8/76 (hsw1n1) virus. virus was recovered for up to eight days after exposure. the virus was readily transmitted to susceptible pen mates. vaccination with inactivated whole-virus vaccine did not provide protection against infection or disease. there was some protection against challenge when the pigs were vaccinated with a temperature-sensitive strain of influenza a/new jersey/8/76 virus.1977606794
experience with monovalent and bivalent influenza vaccines in canada 1976. clinical evaluation of vaccines from four sources.clinical trials in adults of monovalent (200 cca units per dose) and bivalent (400 cca units per dose) inactivated influenza whole virus a/swine and a/victoria vaccines from different sources resulted in variations in clinical reactivity which may not be significant because of lack of controls and observer bias. in adults with no pre-vaccine antibody (hi less than 1/10) the a/swine monovalent vaccine from one source evoked significantly lower response than did the a/swine component of the bivale ...1977342309
swine influenza a at fort dix, new jersey (january-february 1976). iv. summary and speculation.influenza a/new jersey/76 virus was detected at fort dix from january 19 through february 9, 1976 and infected at least 230 military personnel. thirteen hospital admissions for acute respiratory disease were associated with influenza a/new jersey infection, and additional members of index training companies may have been hospitalized with influenza a/new jersey. this virus was likely introduced into the reception center by an incoming trainee. although our studies could not eliminate the possibi ...1977342615
[comparative characteristics of influenza virus a/ussr/02/76 and swine influenza virus].comparative studies of the biological properties, antigenic structure and ultrastructure of influenza a viruses isolated in the ussr, a/new jersey/8/76 and a/swine/31 were carried out. antigenic differences between a/ussr/02/76 and a/swine/31 strains as well as a/new jersey/8/76 strain were found in the hemagglutination-inhibition and neuraminidase activity-inhibition tests. these differences were confirmed by serological examination of human sera.197771790
behaviour in ferrets of swine influenza virus isolated from man.after intranasal instillation into ferrets, the "swine" influenza virus a/new jersey/8/76(hsw1 n1) had a 50% minimal infectious dose similar to that of previously tested a/pr/8-a/england (h3 n2) recombinants virulent and attenuated for man. a/new jersey produced only a mild upper respiratory tract infection. however, higher titres of virus were recovered from the lungs over a longer period than experienced previously with asian and hong kong virus strains. there was a diphasic pyrexia the second ...197763712
antigenic shift in myxoviruses. 197774793
the nurse's role in the swine influenza immunization program. 1977244353
swine influenza virus vaccine: potentiation of antibody responses in rhesus monkeys.polyriboinosinic-polyribocytidylic acid stabilized with poly-l-lysine and carboxymethylcellulose [poly(iclc)] enhances the antibody response in rhesus monkeys immunized with swine influenza virus subunit vaccine. monkeys given the vaccine-adjuvant combination had earlier and significantly (p less than .05) higher titers by 14 days compared to those that received vaccine alone. the potentiation of the antibody response of young monkeys given a split-virus vaccine in combination with poly(iclc) su ...1977408923
ocular abnormalities after influenza immunization. 1977561590
replication of swine and equine influenza viruses in canine kidney cells.both swine and equine influenza viruses were replicated in madin-darby canine kidney cells. hemagglutinin and complement-fixing antigens were synthesized at 4 to 8 hours postinfection and reached maximal synthesis at 16 to 20 hours. neuraminidase activity increased 9- to 11-fold; 50% of the total hemagglutinin antigen was made before the infective virus progeny was detected.197718972
investigations on the involvement of swine influenza a virus (hsw1n1) in the influenza outbreak recorded in a town of romania during the 1976--1977 winter season.seroepidemiological investigations performed with 1,620 serum samples and serodiagnostic tests with 166 paired sera demonstrated that swine influenza virus type a/new jersey 8/76 (hsw1n1) played no role in the epidemiology of human influenza in a large town of romania during 1977.1978567886
genetic dimorphism in influenza viruses: characterization of stably associated hemagglutinin mutants differing in antigenicity and biological properties.influenza virus recombinant x-53 produced for use in the 1976 national immunization program for swine influenza was found to comprise two types of virions differing in their antigenic, replicative, and plaque-forming characteristics. one type, characteristic of x-53 and designated "l," was relatively low-yielding in chicken embryos, produced small clear plaques in madin-darby dog kidney cells, and was selectively inhibited by heterotypic antibody to the a/sw/cam/39 strain of swine influenza viru ...1978282644
influenza a viruses of the h2n2 subtype are lymphocyte mitogens. 1978305001
hemolysis-in-gel (hig) test for antibodies to influenza a, measles and mumps using liquid nitrogen freezed erythrocytes coupled with the respective viral antigen.a drawback with the hemolysis-in-gel test is the constant need for fresh erythrocytes which must be treated with virus before incorporation in the gel. this problem was overcome by freezing small droplets containing erythrocytes to which antigen had been attached. the droplets were stored at -70 degrees c or in liquid nitrogen. this modification was applied in detecting antibodies to influenza, measles and mumps viruses and the results were shown to equal those obtained with fresh erythrocytes.1978102699
the prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine. 197874123
[study of the immunological activity of blood in various rickettsial and viral infections].the content of various types of antibodies were studied in the blood serum of laboratory animals in experimental tick-borne rickettsiosis of northern asia. this was done by a simultaneous staging of indirect hemagglutination, indirect hemolysis, compliment fixation under cold conditions, and agglutination with proteus antigen ox19 tests. immune horse sera to the influenza virus were also studied with the aid of several serological tests. the data obtained pointed to the significant differences i ...1978352050
swine influenza vaccination in a dialysis and transplant population. 1978374434
swine influenza program in st. louis county. 1978634258
public opinion and the swine flu immunization program. 1978647572
surveillance of the swine influenza vaccination program at the royal military college, kingston.in a prospective study symptoms appearing in a previously healthy population within 6 weeks after inoculation with monovalent swine influenza vaccine (a/new jersey/76) were tabulated. of the 703 persons (ranging in age from 17 to 55 years) participating in the follow-up 54% reported experiencing symptoms, usually within 24 hours of vaccination; the symptoms were usually minor and none of the participants displayed evidence of guillain-barré syndrome.1978657050
from the john e. fogarty international center for advanced study in the health sciences. summary of the internationl workshop on the ecology of influenza viruses. 1978681789
antibody response in humans after administration of whole-virion and split vaccine prepared from two different influenza a/swine viruses. 1978721836
secretory antibody response to haemagglutinin of influenza virus a/swine and a/victoria in humans after administration of split and whole-virion vaccine. 1978721837
the swine flu immunization program: a comparison of inoculation recipients and nonrecipients. 197810315848
swine influenza vaccine program in the community: acceptability, reactions and responses.the operation of the national swine influenza immunization program was observed in the community of tecumseh, michigan. the purpose was to determine acceptability of a parenteral vaccine intended for the general population. participation of the residents was excellent. more than 64 per cent of eligibles were vaccinated; this figure resembled that of the rest of the local area, but not the national figures nor a suburban area of michigan where a similar study was carried out. sore arm after vacci ...1979217281
a seroepizootiologic study of five viruses in a swine-evaluation station.this serologic study was done to gain information on the spread, maintenance, and effect upon performance of five porcine viruses. blood samples were taken from two groups of 8- to 11-week-old pigs from a large number of indiana swine herds in a performance-testing station 1 week after entry, 7 weeks after entry (one group only), and at slaughter. the sera were tested by indirect fluorescent antibody tests for antibodies to transmissible gastroenteritis virus (tgev), swine influenza virus (siv), ...1979230762
[incidence of antibodies against influenza viruses a/victoria 3/75 (h3 n2) and a--swine (hsw1 n1) in large pig farms and attendants of pigs in the north moravian region (author's transl)]. 1979159135
the influenza virus: antigenic composition and immune response.the architecture and chemical composition of the influenza virus particle is described with particular reference to the protein constituents and their genetic control. the dominant role in infection of the surface proteins - haemagglutinins and neuraminidases - acting as antigens and undergoing variation in time known as antigenic drift and shift is explained. the immuno-diffusion technique has illuminated the interrelationships of the haemagglutinins of influenza a viruses recovered over long p ...197988726
guillain-barré syndrome: the swine influenza virus vaccine incident in the united states of america, 1976-77: preliminary communication. 1979552571
animals in the influenza world.in the history of influenza there are many references, notes and comments about influenza epizootics occurring among various non-human animals, sometimes coinciding with epidemics of influenza in human beings. that the first influenza viruses were recovered from non-human animals is not so surprising, given the current knowledge of the distribution of influenza among animals. influenza viruses are found in a wide variety of mammalian and avian species. in some species the disease that occurs as ...19806103561
[influenza viruses in man and animals. a literature review (author's transl)].influenza viruses in man and animals. a literature reviewa literature review on the influenza viruses is presented in this paper. a description of the disease in man and domestic animals, as well as general considerations on morphological, physicochemical and antigenic properties of these viruses is given. emphasis is put on the role of the antigenic changes of these viruses with regard to the epidemiology of the disease, as well as on the possible origin of the pandemic and epidemic strains.19806159061
swine flu sequelae. 19806247519
a screening test for influenza immunity: preimmunization antibody titers to influenza virus antigens in atopic patients.antibody titers to three common strains of influenza virus, including the swine flu strain, were determined in 152 patients in an allergy and pediatric allergy practice prior to planned immunization with influenza vaccine. because allergic patients are considered to be more prone to hypersensitivity reactions than individuals who are non-allergic, it was deemed prudent to screen for patients who might have pre-existing protective levels of antibody to the viruses. a considerable number of the 15 ...19806251738
isolation of a recombinant influenza virus (hsw 1 n2) from swine in japan.outbreaks of swine influenza were first observed in japan in 1978. a number of influenza viruses were isolated from diseased swine. almost all viruses isolated were swine influenza virus (hsw 1 n1) but two viruses isolated from the nasal swabs of swine showing clinical signs of influenza in the kanagawa prefecture were characterized antigenically as hsw 1 n2. analysis of swine sera showed that influenza virus hsw 1 n2 was epidemic in the farm from which the virus had been isolated. the new virus ...19806255900
[effectiveness of para-immunization for the control of piglet breeding losses and enzootic pneumonia of swine (piglet influenza)]. 19806257002
[conditions for creating a persistent a/swine/1976/31 infection in cell cultures]. 19806780764
[testing of influenza virus vaccines--an international comparison]. 19807003931
[surveillance of influenza virus in healthy pigs (author's transl)]. 19807471705
[serological survey of human influenza antibodies in domestic animals, poultry and wild birds (author's transl)]. 19807472052
further studies in man of hsw1n1 influenza viruses.two subpopulations of antigenically different hsw1n1 influenza viruses, cloned from 'swine' new jersey virus 1976, were individually inoculated into antibody-free volunteers. one clone contained a haemagglutinin so far seen only in swine viruses prevalent in 1971 and after, the other a haemagglutinin of earlier strains dating back to a least 1957. each of the viruses was infectious for man and intermediate in human virulence between a wild human virus and swine pathogens of 1966 and 1967, which ...19807381437
two forms of influenza virus nucleoprotein in infected cells and virions. 19817467131
evidence for the natural transmission of influenza a virus from wild ducts to swine and its potential importance for man.in 1979, epidemics of influenza occurred in pigs in belgium from which were isolated strains of influenza a (hsw1n1) virus antigenically closely related to hsw1n1 strains previously isolated from ducks in north america and the federal republic of germany. this finding is considered as the first supportive evidence that an influenza a virus in an avian species might have been transmitted to mammals.19816973418
the ecology of influenza viruses: a who memorandum.influenza a viruses continue to be isolated from man, pigs, horses, and a wide range of avian species, especially ducks. the recent isolation of an influenza a virus from seals has added an additional mammal to the list of natural hosts for these viruses. in contrast, influenza b viruses have been isolated only from man.the haemagglutinin of a virus isolated from gulls in the united states of america could not be identified with reference antisera and may constitute a new haemagglutinin subtype. ...19816978194
guillain-barré syndrome and the 1978-1979 influenza vaccine.an ongoing surveillance program was intensified to determine whether an increased risk of acquiring vaccine-related guillain-barré syndrome (gbs) (similar to that observed after vaccination with the a/new jersey swine-influenza vaccine in 1976) existed for the approximately 12.5 million adults (greater than or equal to 18 years old) vaccinated in the 1978-1979 influenza campaign. in the contiguous united states (excluding maryland) 544 cases of gbs with onset between september 1, 1978, and march ...19817231501
registration is not informed consent: the swine flu program revisited. 19817232692
["standard" and "defective" populations of a/swine/1976/31 influenza virus and their role in the development of persistent infection in tissue culture]. 19817253975
the interaction of influenza virus haemagglutinin with phospholipid vesicles - morphological and immunological studies.ha-lipid spheres or "virosomes' were prepared using neutral or negatively charged, but not positively charged, phospholipids. virosomes were similar in size and shape to native virus particles although the ha subunites were at least twofold less numerous on the virosomes. the ha subunites were attached by their narrow end to the lipid bilayer, and could be removed by digestion with bromelain. however, ha subunits released from intact virus by digestion with bromelain, which removed the hydrophob ...19817288397
intrinsic interference between swine influenza and fowl plague virus.multiplication of swine influenza (sw) virus is inhibited by fowl plaque virus (fpv) at the level of rna synthesis when host cells are infected with both viruses at a high multiplicity of infection. under these conditions reassortment between the two viruses cannot be detected. the inhibitory effect of fpv is highly reduced and recombinants between the two viruses could be obtained when the cells were superinfected with fpv 1--2 hours after infection with sw virus, or after simultaneous infectio ...19817295037
[effect of influenza virus on the lung tissue in the immune complex in vitro]. 19817300509
replication of avian influenza a viruses in mammals.the recent appearance of an avian influenza a virus in seals suggests that viruses are transmitted from birds to mammals in nature. to examine this possibility, avian viruses of different antigenic subtypes were evaluated for their ability to replicate in three mammals-pigs, ferrets, and cats. in each of these mammals, avian strains replicated to high titers in the respiratory tract (10(5) to 10(7) 50% egg infective doses per ml of nasal wash), with peak titers at 2 to 4 days post-inoculation, s ...19817309229
[on the immunoserological modification of the human type a influenza virus in animals (author's transl)]. 19817309835
[role of animals in the epidemiology of hunan type a influenza]. 19817313131
serological evidence of infection with h1n1 subtype of influenza virus at dibrugarh, assam. 19817348722
joseph e. smadel memorial lecture. strategy for development of respiratory and gastrointestinal tract viral vaccines in the 1980s. 19817014728
[characteristics of viruses isolated during persistent a/swine/1976/31 virus infection in a monkey kidney cell culture]. 19816789039
[erythrocytes as antigen-carrier for enzyme-immunoassay (author's transl)].it is presented a method, which applied virus absorbing erythrocytes for enzyme-immunoassay. antibodies, immunologically bound to sensitized erythrocytes, are enzyme-serologically detected and microscope-photometrically quantified. the comparison to the immunofluorescent technique shows a strong correlation of the titres r = 0.897.19816791441
serologic and epidemiologic evidence of infection in turkeys with an agent related to the swine influenza virus. 19816791627
[isolation of influenza a viruses with a new antigenic formula from wild birds].three hemagglutinating agents were isolated from mixed pools of the viscera from black-headed gulls (larus ridibundus) and robin (erithacus rubecula) collected in the byelorussian ssa and the kaliningrad region of the rsfsr. typing of the viruses by double immunodiffusion technique revealed antigenic relationships of the viruses with swine hemagglutinin (hsw1) and human hemagglutinin h0. one of the strains had neuraminidase n2 the other two nav2. an analysis of the polypeptide composition of the ...19816455856
[cleavage of influenza virus hemagglutinin as affected by serum plasmin in cell culture and in vivo].the effect of chicken, canine, and porcine plasm containing plasmin proenzyme, plasminogen, on influenza virus hemagglutinin produced in homologous and heterologous tissue cells was studied. the cells incubated with the homologous plasm were found to produce virions containing both cleaved and uncleaved hemagglutinin whereas the cells incubated without plasm or with heterologous plasm produced virions with uncleaved hemagglutinin. the infectious activity of the virus produced by cells with the h ...19816461136
swine influenza virus in swine and man in illinois.serum samples from 2,091 persons from illinois populations of swine abattoir employees, 4-h club youths and their advisors, veterinary medical students, pork producers, and veterinarians were tested for hemagglutination-inhibition (hi) antibodies to a/swine/ill./63. a total of 231 positive reactions of 1:20 or above were found (11%). the highest prevalence of antibody was found in veterinarians, followed by pork producers and future swine abattoir employees. age-adjusted reactor rates were highe ...19816260919
an epizootic of swine influenza in quebec. 19816269718
a serological survey of pigs in india for swine influenza. 19816273310
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