| detection of crimean-congo hemorrhagic fever virus genome in saliva and urine. | the crimean-congo hemorrhagic fever (cchf) virus is transmitted by tick bites and by contact with the blood or tissues of infected patients and livestock. this study was designed to investigate the genome of cchf virus in saliva and urine samples of patients with cchf. | 2010 | 19656706 |
| [crimean-congo haemorrhagic fever: an enemy at the gates]. | crimea-congo haemorrhagic fever is a tick-borne viral zoonosis with the potential of human-to-human transmission. the disease occurs in extensive areas in asia, south-eastern europe and africa. haemorrhagic manifestations constitute a prominent symptom of the late disease stage, with case fatality rates from 9 to 50%. the recent increase in the number of cases in eastern europe and the potential for nosocomial outbreaks indicate the advisability of diagnosis in every patient hospitalized in ital ... | 2009 | 19838084 |
| the trend towards habitat fragmentation is the key factor driving the spread of crimean-congo haemorrhagic fever. | we aimed to characterize an environmental niche driving the distribution of crimean-congo haemorrhagic fever (cchf) in turkey, using a geo-referenced collection of cases reported between 2003 and 2008 and a set of climate and vegetation features. we used mean monthly air temperatures and normalized derived vegetation index (ndvi) values, at a resolution of 0.1 degrees , as well as climate features at and below the surface. we computed significant differences in monthly variables between positive ... | 2010 | 19878611 |
| a newly identified crimean-congo hemorrhagic fever virus strain in turkey. | crimean-congo hemorrhagic fever (cchf) is a fatal viral disease that occurs in approximately 30 countries. it has the most extensive geographic range among the tick-borne viruses that affect human health. recently, a 6-year-old boy presented with complaints of fever, fatigue, and loss of appetite. he revealed a history of tick bite in rural istanbul three days prior to presentation. a hyperemia was detected at the site of the tick bite. laboratory tests showed that alanine aminotransferase, aspa ... | 2010 | 20005760 |
| crimean-congo hemorrhagic fever in iran and neighboring countries. | crimean-congo hemorrhagic fever (cchf) is a zoonotic viral disease that is asymptomatic in infected livestock, but a serious threat to humans. human infections begin with nonspecific febrile symptoms, but progress to a serious hemorrhagic syndrome with a case fatality rate of 2-50%. although the causative virus is often transmitted by ticks, livestock-to-human and human-to-human transmissions also occur. the disease is one of the most widely distributed viral hemorrhagic fevers occurring in afri ... | 2010 | 20006541 |
| molecular epidemiology of crimean-congo hemorrhagic fever virus in turkey: occurrence of local topotype. | the goal of this study was to investigate the molecular epidemiology of crimean-congo hemorrhagic fever virus (cchfv) in turkey. the study was performed on a total of 48 confirmed human cchf cases from 2006 to 2008. the majority of the cchf viral strains in turkey were found to belong to the european lineage. local cchf viral strains are grouped into two main clusters, which can be further divided into two sub-groups. we also identified an ap92-like virus causing clinical disease in corum (a mid ... | 2010 | 20079776 |
| [evaluation of pcr and elisa-igm results in the laboratory diagnosis of crimean-congo haemorrhagic fever cases in 2008 in turkey]. | crimean-congo hemorrhagic fever (cchf) is a fatal zoonotic viral haemorrhagic infection described in africa, asia, eastern europe, and the middle east. cchf virus (cchfv) classified in bunyaviridae family and nairovirus genus, is transmitted to humans by tick (hyalomma and ixodid) bites and human to human transmission may occur by direct contact with blood or other infected tissues. the disease became endemic and a public health problem since 2002 outbreak in turkey. the specific laboratory diag ... | 2010 | 20455399 |
| early serodiagnosis of acute human crimean-congo hemorrhagic fever virus infections by novel capture assays. | | 2010 | 20541967 |
| crimean-congo haemorrhagic fever presenting as epididymo-orchitis. | crimean-congo haemorrhagic fever (cchf) is a potentially fatal disease caused by a tick-borne virus. | 2010 | 20598630 |
| ixodid ticks (acari: ixodidae) infesting humans in tokat province of turkey: species diversity and seasonal activity. | ixodid ticks (acari: ixodidae) are the major vectors of pathogens threatening animal and human health. tokat province, turkey, is a suitable habitat for extended tick activity with its moderate climate and vegetation. in the present study, we surveyed humans visiting health centers to determine the species diversity, geographical distribution, and seasonal activity of ixodid ticks infesting them. out of 5,999 adult ticks collected from humans from april to september, 2008, 800 ticks were identif ... | 2010 | 20618665 |
| pathogenesis and immune response of crimean-congo hemorrhagic fever virus in a stat-1 knockout mouse model. | tick-borne crimean-congo hemorrhagic fever virus (cchfv) causes a severe hemorrhagic syndrome in humans but not in its vertebrate animal hosts. the pathogenesis of the disease is largely not understood due to the lack of an animal model. laboratory animals typically show no overt signs of disease. here, we describe a new small-animal model to study cchfv pathogenesis that manifests clinical disease, similar to that seen in humans, without adaptation of the virus to the host. our studies revealed ... | 2010 | 20739514 |
| re-emergence of crimean-congo hemorrhagic fever virus in central africa. | crimean-congo hemorrhagic fever (cchf) is a severe tick-borne disease well recognized through europe and asia where diagnostic tests and medical surveillance are available. however, it is largely neglected in africa, especially in the tropical rainforest of central africa where only sporadic human cases have been reported and date back to more than 30 years. we describe here an isolated human case that occurred in the democratic republic of the congo in 2008 and performed phylogenetic analysis t ... | 2011 | 22022629 |
| Bacterial expression of Crimean-Congo hemorrhagic fever virus nucleoprotein and its evaluation as a diagnostic reagent in an indirect ELISA. | Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne viral zoonosis distributed widely in Africa, Asia, Russia and the Balkans. The emergence and re-emergence of CCHFV emphasize the importance of increasing both human and veterinary surveillance and developing diagnostic capacity. Recombinant CCHFV nucleocapsid protein (NP) has been expressed using insect cells and mammalian cells and used as a diagnostic tool but bacterial expression has not been described previously. The S gene of CCH ... | 2012 | 22001274 |
| molecular detection of crimean-congo haemorrhagic fever virus in ticks collected from infested livestock populations in a new endemic area, south of iran. | crimean-congo haemorrhagic fever (cchf) is a viral zoonotic disease with potentially fatal systemic effects on man. we aimed to determine the presence of cchf virus among collected ticks from domestic livestock from october 2012 to september 2013. | 2016 | 26758985 |
| seroepidemiological study of crimean-congo haemorrhagic fever in greece, 2009-2010. | clin microbiol infect abstract: to estimate endemic areas for crimean-congo haemorrhagic fever (cchf) in greece, a country-wide seroepidemiological study was conducted, and 1611 human sera were prospectively collected along with data regarding possible risk factors for acquisition of infection, and tested for cchf virus igg antibodies by elisa. the overall seroprevalence was 4.2%, with significant differences among prefectures, ranging from 0 to 27.5%. multivariate analysis revealed that slaught ... | 2011 | 22192082 |
| Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human pathogenic Crimean-Congo Haemorrhagic Fever virus. | Hazara virus (HAZV) is closely related to Crimean-Congo Haemorrhagic Fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose response effects were seen, with higher doses resulting in a shorter time to ... | 2011 | 22090213 |
| crimean-congo hemorrhagic fever serosurvey in at-risk professionals, madagascar, 2008 and 2009. | crimean-congo hemorrhagic fever (cchf) is a zoonotic arboviral infection with hemorrhagic manifestation and often a fatal ending. human become infected mainly through tick bite or by crushing infected tick, by contact with blood or tissues from viraemic livestock or patient. cchf virus (cchfv) has been isolated once in madagascar but data on the epidemiology of the disease in the country are very scarce. | 2011 | 21889395 |
| tick-borne viruses in europe. | the aim of this review is to present briefly background information on 27 tick-borne viruses ("tiboviruses") that have been detected in europe, viz flaviviruses tick-borne encephalitis (tbev), louping-ill (liv), tyuleniy (tyuv), and meaban (meav); orthobunyaviruses bahig (bahv) and matruh (mtrv); phleboviruses grand arbaud (gav), ponteves (ptvv), uukuniemi (uukv), zaliv terpeniya (ztv), and st. abb's head (sahv); nairoviruses soldado (solv), puffin island (piv), avalon (avav), clo mor (cmv), cri ... | 2012 | 22526290 |
| development of a real-time rt-pcr assay for the detection of crimean-congo hemorrhagic fever virus. | abstract crimean-congo hemorrhagic fever (cchf) is a virulent tick-borne disease with a case fatality rate ranging from 10-50% for tick-borne transmission, and up to 80% for nosocomial transmission. human cases have been reported in over 30 countries across europe, asia, and africa. it appears to be spreading to new areas with several countries reporting their first human cases of cchf disease within the past 10 years. we report a novel real-time rt-pcr assay designed to amplify a conserved re ... | 2012 | 22217175 |