Publications

clinical diagnosis and treatment of human granulocytotropic anaplasmosis.	tick-borne rickettsiae in the genera ehrlichia and anaplasma are intracellular bacteria that infect wild and domestic mammals and, more recently, man. the increased desire of humans for recreational activities outdoors has increased the exposure to potential human pathogens that previously cycled almost exclusively within natural, nonhuman enzootic hosts. anaplasma phagocytophilum causes an acute, nonspecific febrile illness of humans previously known as human granulocytotropic ehrlichiosis (hge ...	2006	17114714
prevalence of bacterial agents in ixodes persulcatus ticks from the vologda province of russia.	the prevalence of rickettsiae, ehrlichiae, and the rickettsia-like endosymbiont called montezuma relative to that of borrelia was determined in questing ixodes persulcatus (i. persulcatus) ticks collected in 2002-2003 from vologda province, russia. ehrlichia muris, anaplasma phagocytophilum, montezuma, and new spotted fever group rickettsiae were detected by polymerase chain reaction (pcr) for the first time in this area. the rickettsiae were all candidatus rickettsia tarasevichiae, the furthest ...	2006	17114724
[investigation on borrelia burgdorferi sensu lato in ticks and rodents collected in da xing-an mountains forest areas of china].	to detect and study the types of borrelia burgdorferi sensu lato in ticks and rodents from da xing-an mountains forest areas of china.	2006	17172108
[detection of dna of borrelia circulating in novosibirsk region].	detection of dna of borrelia burgdorferi sensu lato was performed by pcr in taiga ticks ixodes persulcatus, in blood samples and skin bioptates of small forest mammals, and in blood and urine samples of humans after attaching of ticks events. in novosibirsk region both in natural reservoir and in patients with ixodes ticks-borne borreliosis dna of borrelia garinii and borrelia afzelii are detected. dna of these borrelia were detected in 8 from 72 of taiga ticks, in 36 from 298 of blood and skin ...	2006	17297875
[investigation on the vectors of borrella burgdorferi and on the identification of the isolates along china-russia border in eastern heilongjiang province, china].	to explore the fact that the east border of heilongjiang had been a lyme disease natural focus,we investigated the species and distribution of ticks and isolated bacteria from ticks and identified genomic species of borrelia burdorferi sensu lato. this study provided evidence for prevention and control of lyme disease.	2007	17575937
detection and identification of bacterial agents in ixodes persulcatus schulze ticks from the north western region of russia.	ixodes persulcatus schultze ticks are traditionally associated with transmission of lyme disease, babesiosis, and tick-borne encephalitis. here we compared the prevalence of infection with borrelia burgdorferi, and rickettsial and ehrlichial agents in i. persulcatus ticks collected in different locations of the north western administrative region of russia. altogether, 27.7% of ticks were infected with at least one organism, while the dna of two or more bacteria was found in 11.8% of ticks teste ...	2007	17767409
ultrastructural evidence of the ehrlichial developmental cycle in naturally infected ixodes persulcatus ticks in the course of coinfection with rickettsia, borrelia, and a flavivirus.	ehrlichiae are small gram-negative obligately intracellular bacteria that multiply within vacuoles of their host cells and are associated for a part of their life cycle with ticks, which serve as vectors for vertebrate hosts. two morphologically and physiologically different ehrlichial cell types, reticulate cells (rc) and dense-cored cells (dc), are observed during experimental infection of cell cultures, mice, and ticks. dense-cored cells and reticulate cells in vertebrate cell lines alternate ...	2007	18171109
prevalence of anaplasma phagocytophilum and its coinfection with borrelia afzelii in ixodes ricinus and ixodes persulcatus ticks inhabiting tver province (russia) - a sympatric region for both tick species.	human granulocytic anaplasmosis (hga) and lyme borreliosis (lb) are tick-borne infectious diseases caused by anaplasma phagocytophilum and borrelia burgdorferi sensu lato species, respectively. in this study, p44/msp2 paralogues specific to a. phagocytophilum and 5s-23s rrna gene-intergenic spacers specific to b. burgdorferi sensu lato species were detected by pcr in ticks collected in two regions, tver (kalinin) and konakovo, of the tver (kalinin) province located 150 km north-west of moscow. t ...	2008	18628500
[spatial and temporal variability of ixodes ricinus and ixodes persulcatus infection with the lyme disease agent in moscow region].	analysis of long-term data on the infection rated of the taxonomic complex borrelia burgdorferi s. l. in ixodes persulcatus and i. ricinus from moscow region is carried out. more than 14 000 tick specimens were examined by dark-field microscopy and 704 specimens were investigated by pcr. two borrelia genospicies, b. afzelii (6.3%) and b. garinii (20%) proved the most prevalent. the genospecies could form a mixtinfection (11%). borrelia miyamotoi, b. valaisiana, and b. burgdorferi s. s. were also ...	2008	19198169
molecular identification of salp15, a key salivary gland protein in the transmission of lyme disease spirochetes, from ixodes persulcatus and ixodes pacificus (acari: ixodidae).	salp15 is a multifunctional protein, vital to the tick in its need to obtain vertebrate host blood without stimulating a host inflammatory and immune response. the salpl5 protein from both ixodes scapularis say and ixodes ricinus (l.), the principal vectors of the lyme disease spirochete in eastern north america and europe, respectively, have been well characterized and found to bind the murine cd4 receptor, dc-sign, and the ospc protein of borrelia burgdorferi. in the current study, we characte ...	2009	19960697
two novel salp15-like immunosuppressant genes from salivary glands of ixodes persulcatus schulze tick.	salp15, a 15-kda tick salivary gland protein, is known for several suppressive activities against host immunity and critical functions for the transmission of lyme borrelia in ixodes scapularis and ixodes ricinus, the major vectors found in north america and western europe. salp15 inhibits the activation of cluster of differentiation (cd)4(+)t-cells through the repression of t-cell receptor (tcr)-triggered calcium fluxes and interleukin (il)-2 production. furthermore, salp15 adheres to the spiro ...	2010	20201978
genetic diversity of borrelia burgdorferi sensu lato isolates from northeastern china.	thirty-two strains of borrelia burgdorferi sensu lato were isolated from ixodes persulcatus ticks collected from northeastern china from may to june in 2004 and 2005. restriction fragment length polymorphism (rflp) analysis and sequence analysis of 5s-23s rrna intergenic spacer revealed that 29 (90.6%) belonged to borrelia garinii, demonstrating b, c, and a unique pattern. the remaining three isolates (9.4%) were borrelia afzelii with pattern d. the phylogenetic analysis based on 5s-23s rrna int ...	2010	21142958
[isolation and identification of borrelia burgdorferi sensu lato from ticks in six provinces in china.]	objective: to understand the carrying status of borrelia burgdorferi in ticks from the mountain areas from six representative provinces, including jilin, shanxi, gansu, qinghai, guizhou and hunan in china. methods: flagging and trapping methods were used to collect ticks in forest area and culture medium was used to isolate the pathogen. nested-pcr was used to detect the germ-carrying rate of ticks. results: more than 2200 ticks from six representative provinces were collected and 1000 ticks wer ...	2010	21223661