| effect of t4 count and cofactors on the incidence of aids in homosexual men infected with human immunodeficiency virus. | we prospectively evaluated potential markers and cofactors for the acquired immunodeficiency syndrome (aids) in 86 homosexual men who were seropositive for human immunodeficiency virus antibodies. during three years of follow-up, 19 men developed aids. risk of aids was clearly predicted by the total number of circulating okt4-positive lymphocytes (t4 count) at enrollment, while the corresponding t8 count was unrelated to subsequent aids development. subjects in manhattan had a higher risk of kap ... | 1987 | 3491911 |
| neoplastic complications of htlv-iii infection. lymphomas and solid tumors. | neoplastic disease arose in 29 of 200 patients infected with human t lymphotropic virus type iii (htlv-iii) seen at a suburban hospital. seventeen patients had kaposi's sarcoma, one of whom also had colon carcinoma. nine patients had lymphoproliferative disorders (seven lymphomas, one t suppressor cell chronic lymphocytic leukemia, and one multiple myeloma), including three with concomitant kaposi's sarcoma and one with colon cancer. one other patient had colon cancer, one had a seminoma, and on ... | 1987 | 3493690 |
| origin and transmission of aids. multi-use hypodermics and the threat to the soviet union: discussion paper. | health authorities in the soviet union have attempted to downplay the prevalence of infection with human immunodeficiency virus (hiv) in the soviet population and to suppress the publication of scientific articles on acquired immunodeficiency syndrome (aids). nonetheless, there is some evidence that the ussr may have more aids cases than any other country in europe. particularly prevalent are cases of kaposi's sarcoma in persons under 40 years of age. it is hypothesized that the multi-use of ... | 1987 | 3612664 |
| suramin therapy in aids and related disorders. report of the us suramin working group. | suramin sodium is a reverse transcriptase inhibitor with in vitro activity against the human immunodeficiency virus (hiv), the causative agent of acquired immunodeficiency syndrome (aids). ninety-eight patients with aids manifest as opportunistic infections (n = 38), aids with kaposi's sarcoma (n = 38), aids-related complex (n = 20), or aids-associated non-hodgkin's lymphoma (nhl) (n = 2) were treated with suramin sodium at 0.5, 1.0, or 1.5 g/wk for six weeks followed by maintenance therapy with ... | 1987 | 3650339 |
| eosinophilic vasculitis leading to amaurosis fugax in a patient with acquired immunodeficiency syndrome. | a 49-year-old bisexual man with generalized lymphadenopathy and antihuman t lymphocyte virus, type iii, (htlv-iii) antibodies presented with recurrent, unilateral amaurosis fugax. a temporal artery biopsy specimen showed eosinophilic vasculitis. the patient then developed acquired immunodeficiency syndrome with kaposi's sarcoma. we describe this patient because of the unusual association of large vessel vasculitis and acquired immunodeficiency syndrome. | 1986 | 3767551 |
| lymphadenopathy-associated viral antibody in aids. immune correlations and definition of a carrier state. | we investigated whether serologic evidence of lymphadenopathy-associated virus (lav), an exogenous human t-cell lymphotropic and cytopathic retrovirus, correlated with the acquisition and transmission of the acquired immunodeficiency syndrome (aids). serum from 17 of 25 patients with aids contained circulating igg anti-lav antibody (all of 5 adults with cancer and 6 of 12 adults and 6 of 8 children with opportunistic infections, with or without kaposi's sarcoma). all of eight homosexual men with ... | 1984 | 6092953 |
| african kaposi's sarcoma and aids. | 16 zambian patients with kaposi's sarcoma (ks) were studied to determine whether they had evidence of lymphopenia with decreased t helper/t suppressor (th/ts) ratios or previous infection with opportunistic pathogens. serological tests for viruses commonly associated with the acquired immunodeficiency syndrome (aids) were also carried out. 12 patients had a decreased th/ts and 2 of these were also lymphopenic. serological evidence for infection with toxoplasma and with pneumocystis was present b ... | 1984 | 6142209 |
| toxicity, immunosuppressive effects and carcinogenic potential of volatile nitrites: possible relationship to kaposi's sarcoma. | volatile nitrite in the form of amyl nitrite was used for 100 years for the treatment of angina pectoris. in spite of recognized toxicity, its use in this form was considered safe. during the 1960s prescriptions were not required for purchase of amyl nitrite (called poppers) and its use for recreational purposes became popular. with reinstatement of the prescription requirement in 1969, non-medicinal, street-variety volatile nitrites were made commercially available in the form of mixtures of im ... | 1984 | 6150466 |
| opportunistic infections and kaposi's sarcoma among haitians: evidence of a new acquired immunodeficiency state. | twenty haitian patients, hospitalized from 1 april 1980 to 20 june 1982, had pneumocystis carinii pneumonia, central nervous system toxoplasmosis, esophageal candidiasis, cryptococcosis, disseminated cytomegalovirus, progressive herpes simplex virus, chronic enteric coccidiosis, or invasive kaposi's sarcoma. ten patients died. opportunistic infections were frequently multiple and were recurrent in three patients. in seven patients disseminated tuberculosis preceded the other infections by 2 to 1 ... | 1983 | 6299151 |
| seminal fluid excretion of cytomegalovirus related to immunosuppression in homosexual men. | seminal fluid samples from 84 danish homosexual men were successfully cultured to determine the prevalence of cytomegalovirus excretion. ten (15%) out of 66 men positive for the antibody were found to be excreting the virus. although the proportion excreting was inversely related to age (p less than 0.01), three men aged over 30 and with many years of homosexual experience excreted the virus. in addition, a 50 year old man with kaposi's sarcoma excreted the virus. a further study of the ratio of ... | 1983 | 6307459 |
| oncological consequences of impaired immune surveillance against ubiquitous viruses. | the immune system is constantly challenged by ubiquitous viruses. multiple immune defenses have evolved to meet these challenges, and thus immunocompetent individuals successfully respond to infection without sequela. x-linked lymphoproliferative syndrome patients, renal allograft recipients, and acquired immunodeficiency syndrome patients share impaired immune surveillance as a common feature. such individuals are variously susceptible to numerous untoward complications following infection with ... | 1983 | 6309892 |
| speculations on the viral etiology of acquired immune deficiency syndrome and kaposi's sarcoma. | the acquired immune deficiency syndrome (aids) appeared in the united states in late 1978 and has spread at an epidemic rate through the four major coastal cities of this country. the disease appears to show the same epidemiologic distribution as hepatitis b virus infection, and for this reason, most investigators feel that this new disease is caused by a blood-borne sexually transmitted virus. a number of viral agents have been suggested as the cause of aids, but to date, no virus has been cons ... | 1984 | 6330223 |
| hsv, cmv, and hpv in human neoplasia. | we are studying the role of sexually transmitted viruses in the development of human tumors. the persistence of herpes simplex virus, cytomegalovirus, and human papillomavirus nucleic acid sequences has been examined using cloned viral dna sequences as probes. the relationship of the viruses to various stages in the progression of neoplasia is examined, with particular reference to the role of viral and/or cellular genes in the initiation, promotion, and maintenance of the neoplastic phenotype. ... | 1984 | 6330227 |
| tumor conference no 51 widespread kaposi's sarcoma in a young man. | | 1984 | 6537812 |
| systemic treatment of kaposi's sarcoma: current status and future directions. | kaposi's sarcoma (ks) is a complex neoplasm of cells of endothelial and fibroblast origin, whose proliferation is maintained by the viral product tat, cytokines, and maybe environmental factors. it was among the first noted clinical manifestations of aids and remains the most common malignancy observed in patients infected with hiv, yet an optimal treatment strategy remains to be identified. the authors discuss current options and future directions for the systemic treatment of ks. they do no ... | 1994 | 7519018 |
| identification and culture of kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controls. | we examined 26 patients with human immunodeficiency virus-1 (hiv-1)-associated kaposi's sarcoma (ks), and 76 hiv-1-infected (hiv-1+) people without ks or uninfected (hiv-1-) controls for the presence of circulating ks-like spindle cells. adherent cells that had spindle morphology and several characteristics of spindle cells of ks lesions (ks cells) were identified in the peripheral blood mononuclear cell fraction only after culture in the presence of conditioned medium (cm) from activated lympho ... | 1994 | 7522639 |
| the hiv-1 tat protein induces the expression and extracellular appearance of acidic fibroblast growth factor. | mounting experimental evidence suggests that the tat protein, released from human immunodeficiency virus-1 (hiv-1)-infected inflammatory cells, may genetically reprogram targeted cells within a localized environment to develop highly vascularized tumors of mesenchymal origin. the fibroblast growth factor (fgf) family of polypeptides has gained general acceptance as initiators of angiogenesis and functions as potent mitogens for mesoderm-derived cells. to evaluate a potential biological relations ... | 1995 | 7542239 |
| childhood cancers in zambia before and after the hiv epidemic. | human immunodeficiency virus (hiv) related cancers in children are not as common and as well described as in adults. an hiv epidemic has been prevalent in zambia since 1983-1984. to study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the university teaching hospital (uth), lusaka, zambia. all the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. in ... | 1995 | 7574850 |
| herpesvirus-like dna sequences in non-aids kaposi's sarcoma. | the pathogenesis of kaposi's sarcoma (ks) is suggested to be related to an infectious agent transmitted by sexual contact. recently, dna sequences homologous to gamma herpesviridae have been identified in aids-associated ks, but no information is available concerning non-aids-associated ks. five classic, 12 endemic, and 17 aids-associated ks skin lesion specimens were analyzed and all were positive for these novel dna sequences. twenty-four specimens from normal skin were negative. these novel s ... | 1995 | 7594727 |
| perspectives of cytokine treatment in malignant skin tumors. | cytokines have been tested in the treatment of different skin cancers during the last decade, and treatment schedules have been established or proposed for several malignant skin tumors. preferentially, the interferons and interleukin-2 were found to be effective in treating skin cancers. interferons alpha and beta have been approved for the treatment of human immunodeficiency virus (hiv)-associated kaposi's sarcoma, cutaneous t cell lymphoma, and malignant melanoma in several countries. interfe ... | 1995 | 7597303 |
| human immunodeficiency virus and the skin: selected controversies. | acquired immunodeficiency syndrome was first recognized as a new disease in 1981 because of the unusual association of kaposi's sarcoma and pneumocystis carinii pneumonia in young men. the skin remains one of the most important clinical markers for acquired immunodeficiency syndrome, now recognized as the end stage of infection with the human immunodeficiency virus (hiv). indeed, an urticarial viral exanthem appearing during seroconversion may allow early identification of newly infected individ ... | 1995 | 7615989 |
| human herpesvirus type 6 and cytomegalovirus in aids-associated kaposi's sarcoma: no evidence for an etiological association. | epidemiological studies indicate that acquired immune deficiency syndrome (aids)-associated kaposi's sarcoma (ks) may be caused by an infectious, preferentially sexually transmitted agent. herpesviruses infections are common sexually transmitted diseases in homosexual men, who are also the main risk group for developing kaposi's sarcoma. to evaluate a possible role of human herpesvirus-6 (hhv-6) and cytomegalovirus (cmv) in the development of aids-associated ks, we investigated cutaneous aids-as ... | 1995 | 7635454 |
| pattern of adult malignancies in zambia (1980-1989) in light of the human immunodeficiency virus type 1 epidemic. | this study analysed histopathological and haematology records of 7836 neoplasms seen during the period 1980-1989 at the university teaching hospital, lusaka, zambia. the crude incidence rate of each malignancy per 100,000 adults per year was calculated and the patterns of malignancies were compared for the periods 1980-1983 and 1984-1989, the later coinciding with the advent of the human immunodeficiency virus (hiv) epidemic. the six most common tumours were carcinoma of the cervix (19.6%), kapo ... | 1995 | 7636927 |
| lower extremity lymphedema caused by acquired immune deficiency syndrome-related kaposi's sarcoma: case report and review of the literature. | a case of severe lymphedema of the lower extremity caused by obstruction by human immunodeficiency virus-associated kaposi's sarcoma is presented. a review of the signs and symptoms of obstructive lymphedema and kaposi's sarcoma is provided. early recognition of this clinical entity may allow use of simple preventative measures and help to avoid this life- and limb-threatening situation. | 1995 | 7637119 |
| rehabilitation management of the lower extremity in hiv disease. | the sequelae of human immunodeficiency virus (hiv) disease include a host of devastating conditions involving the lower extremity. these include rheumatologic dysfunction, kaposi's sarcoma, peripheral neuropathies, and skin ulcers. pain, weakness, and loss of range of motion caused by these conditions can lead to changes in gait pattern, loss of mobility and function, and limited quality of life. the role of the rehabilitation specialist in the care and treatment of hiv disease as it affects the ... | 1995 | 7643317 |
| photodynamic therapy in aids-related cutaneous kaposi's sarcoma. | for evaluating the role of photodynamic therapy (pdt) in the local treatment of acquired immune deficiency syndrome (aids)-related cutaneous kaposi's sarcoma (ks), nine treatments were performed in eight human immunodeficiency virus-positive homosexual men. the patients received 2 mg photofrin/kg and either 120 j/cm2 (n = 5) or 70 j/cm2 (n = 4) laser light (630 nm). a total of 83 lesions were evaluable for response with a follow-up of 3-8 months. the overall response rates by patient for all tre ... | 1995 | 7648286 |
| association of human herpes virus with pulmonary kaposi's sarcoma. | | 1995 | 7658860 |
| detection of kaposi sarcoma associated herpesvirus in peripheral blood of hiv-infected individuals and progression to kaposi's sarcoma. | kaposi sarcoma-associated herpesvirus (kshv) is consistently found in biopsy samples from patients with aids-related and "classical" kaposi's sarcoma (ks). although highly suggestive of a causal role of kshv in the pathogenesis of ks, this observation does not exclude the possibility that kshv, like other herpesviruses, is widely distributed and is a mere "passenger" in these lesions. here we report that kshv was detectable in peripheral blood mononuclear cells of 24/46 (52%) of ks patients, but ... | 1995 | 7674745 |
| chemotherapy for patients with pulmonary kaposi's sarcoma: benefit of filgrastim (g-csf) in supporting dose administration. | kaposi's sarcoma (ks) is common in individuals infected with the human immunodeficiency virus (hiv-1). although ks is frequently indolent, it can also be aggressive and life-threatening, especially in patients with pulmonary involvement (pks), who have poor survival rates when untreated. in an effort to develop treatment regimens for pks that would prolong life or reduce clinical symptoms, we used combination chemotherapy to treat 18 patients who had aids and pks; 13 (72%) of them had a history ... | 1993 | 7694375 |
| changing patterns of kaposi's sarcoma in danish acquired immunodeficiency syndrome patients with complete follow-up. the danish study group for hiv infection (dashi). | the objective was to study changes in the occurrence of human immunodeficiency virus type 1-related kaposi's sarcoma and the association with degree of immunodeficiency over time. danish patients with acquired immunodeficiency syndrome (aids) diagnosed between 1979 and 1990 (n = 687) were followed clinically and with consecutive cd4 cell count measurement from time of aids-defining illness to date of death or censoring date, whichever came first. the proportion of homo-/bisexual men (n = 520) wi ... | 1995 | 7702040 |
| management of pulmonary kaposi's sarcoma: new perspectives. | pulmonary kaposi's sarcoma is a frequent complication of human immunodeficiency virus infection. this article reviews the current approaches to the management of this difficult condition. | 1995 | 7788074 |
| lytic vertebral lesions: an unusual manifestation of aids-associated kaposi's sarcoma. | the differential diagnosis of neovascular skin lesions in patients with aids includes kaposi's sarcoma and bacillary angiomatosis. it has been suggested that the radiographic presence of lytic bone lesions in association with these skin lesions supports a diagnosis of bacillary angiomatosis. we present a case of disseminated kaposi's sarcoma in which evidence of lytic vertebral disease was seen on computed tomography; the histopathologic characteristics of the osseous lesions are described. find ... | 1994 | 7803643 |
| role of hiv-1 tat in the pathogenesis of aids-associated kaposi's sarcoma. | | 1994 | 7826041 |
| retrovirus-mediated transfer and long-term expression of hiv type 1 tat gene in murine hematopoietic tissues. | replication of the human immunodeficiency virus (hiv) is regulated tightly by the tat and rev genes. the tat gene of hiv is a potent trans-activator of virus gene expression. trans-activation is mediated through the tat-responsive element (tar). tat also has been shown to affect transcription of cellular genes and to trans-activate other viral promoters. in transgenic animals, tat expression in skin was implicated in the development of lesions resembling kaposi's sarcoma (ks). more recently, evi ... | 1994 | 7888206 |
| human herpesvirus-like nucleic acid in various forms of kaposi's sarcoma. | the association between a new human herpesvirus-like agent and various forms of kaposi's sarcoma was examined by pcr. the dna sequences of this agent were detected in 7 of 8 classic kaposi's sarcoma specimens, 12 of 12 aids-associated specimens from the united states, and 7 of 10 specimens from african endemic kaposi's sarcoma. polymorphism of the herpesvirus-like dna in the kaposi's tissue from different populations was observed by both single-strand conformational polymorphism and direct seque ... | 1995 | 7891487 |
| [detection of markers of the human t-cell leukemia virus in patients with t-cell lymphoma and kaposi's sarcoma]. | nine patients with kaposi's sarcoma and five suffering from t-cell lymphoma have been examined. antibodies to htlv-1 were not found in these patients. the primary cellular cultures were isolated from blood and lymph nodes of the patients. viral particles (type c) were found in the culture obtained from the patient with lymphoma of t-cell origin. dnas from the primary cellular cultures from patients with lymphoma or sarcoma contained the sequences homologous to gag-gene of htlv-1. the data suppos ... | 1994 | 7891727 |
| serum levels of intercellular adhesion molecule 1 in patients with hiv-related kaposi's sarcoma. | infection with the human immunodeficiency virus type 1 (hiv-1) in man is associated with an increase in the incidence of kaposi's sarcoma (ks). the biological and clinical characteristics of these patients differ from those of subjects with other hiv-associated diseases. here we report that levels of serum-soluble intercellular adhesion molecule 1 (sicam 1) are increased in hiv-1-positive patients with ks, but not in patients belonging to other cdc classification groups. ks patients with elevate ... | 1994 | 7911526 |
| hiv-related oral manifestations in two cohorts of women in san francisco. | the goals of this study were to compare the prevalence of oral lesions in women infected with human immunodeficiency virus (hiv) and hiv-negative women, and to determine the association of oral lesions with route of hiv transmission and with level of immunosuppression in infected women. as part of a prospective 4-year study, oral examinations and blood tests were performed, at 6-month intervals, on 176 hiv-infected women and on 117 hiv-negative women at risk for hiv infection. we evaluated parti ... | 1994 | 7914233 |
| laparotomy in patients infected with human immunodeficiency virus: indications and outcome. | four distinct disease processes account for the majority of surgically correctable intra-abdominal pathologies associated with human immunodeficiency virus (hiv) infection: cytomegalovirus infection, kaposi's sarcoma, non-hodgkin's lymphoma and mycobacterial infection. affected patients may also develop acute cholecystitis and appendicitis with significant frequency. thorough investigation, when possible, will obviate the need for laparotomy in most hiv-infected patients with abdominal symptoms ... | 1994 | 7922084 |
| identification of herpesvirus-like dna sequences in aids-associated kaposi's sarcoma. | representational difference analysis was used to isolate unique sequences present in more than 90 percent of kaposi's sarcoma (ks) tissues obtained from patients with acquired immunodeficiency syndrome (aids). these sequences were not present in tissue dna from non-aids patients, but were present in 15 percent of non-ks tissue dna samples from aids patients. the sequences are homologous to, but distinct from, capsid and tegument protein genes of the gammaherpesvirinae, herpesvirus saimiri and ep ... | 1994 | 7997879 |
| esophageal disease in human immunodeficiency virus infection. | up to 40% of patients with the acquired immunodeficiency syndrome may develop symptoms of esophageal disease. candida esophagitis is responsible for the majority of the cases of esophageal disease; cytomegalovirus, herpes simplex, idiopathic esophageal ulcers, and kaposi's sarcoma account for most of the remaining cases. although endoscopy with esophageal biopsy and brushing is the gold standard for the diagnosis of esophageal disease in the acquired immunodeficiency syndrome, we generally recom ... | 1994 | 8031205 |
| urgency of medical care. contrasting perceptions of hiv-positive patients and physicians. | to assess the agreement between patients and physicians about the appropriate time to seek medical attention for symptom complexes commonly encountered in human immunodeficiency virus (hiv) disease, identifying potential suboptimal utilization of health care services. | 1994 | 8053755 |
| bacillary angiomatosis: a new entity in acquired immunodeficiency syndrome. | since the recognition of the acquired immunodeficiency syndrome (aids) in 1981, previously rare infections and neoplasms have become increasingly common. bacillary angiomatosis, undescribed in the medical literature prior to 1983, is now second in frequency only to kaposi's sarcoma with respect to the cutaneous manifestations associated with human immunodeficiency virus (hiv) infection. caused by rochalimaea henselae, bacillary angiomatosis is easily treated, when diagnosed early, with erythromy ... | 1994 | 8064965 |
| cancer and viruses. | viruses implicated in the development of human cancers include hepatitis b (and c) viruses in hepatocellular carcinoma; human papillomaviruses in anogenital cancers; epstein-barr virus in nasopharyngeal carcinoma and burkitt's lymphoma; human t-cell leukaemia/lymphoma viruses in adult t-cell leukaemia/lymphoma; and indirectly, human immunodeficiency viruses in kaposi's sarcoma and b-cell lymphoma. together, they contribute significantly to the cancer statistics in the southeast asian region. neo ... | 1993 | 8103316 |
| bacillary angiomatosis. clinical and histologic features, diagnosis, and treatment. | bacillary angiomatosis is a relatively new infection affecting primarily patients with human immunodeficiency virus or others with impaired host defenses. it presents most commonly with multiple red skin lesions, but visceral involvement may also occur, including involvement of the liver and spleen. because of the dermatologic manifestations, bacillary angiomatosis may be mistaken for kaposi's sarcoma. the diagnosis is made by identification of the characteristic histologic findings or genetic a ... | 1994 | 8122945 |
| risk factors for kaposi's sarcoma in patients with advanced human immunodeficiency virus disease treated with zidovudine. zidovudine epidemiology study group. | although the cause of kaposi's sarcoma (ks) is unknown, its unique epidemiology suggests that an infectious, sexually transmitted agent or agents may contribute to its pathogenesis. | 1994 | 8122950 |
| [isolated rectal kaposi's sarcoma]. | we report a case of isolated rectal kaposi's sarcoma in a homosexual man with active human immunodeficiency virus infection. although gastrointestinal tract affection is not infrequent, it is usually associated with the existence of skin lesions. a few cases of noncutaneous gastrointestinal kaposi's sarcoma have been described, but no one affecting only the rectum. this is a diagnostic possibility in patients with human immunodeficiency virus infection and rectal symptoms. | 1993 | 8129997 |
| aids-related kaposi's sarcoma: a review. | infection with the human immunodeficiency virus (hiv) is the primary cause of aids and related disorders. infection with hiv results in diminished cellular immunity, propensity to opportunistic infections, and an increased incidence of certain neoplasms. kaposi's sarcoma (ks) is the most common neoplasm in persons infected with hiv. this epidemic, or hiv-related ks, usually follows an aggressive course with involvement of skin, lymph nodes, and internal organs. normally, the disease has a progre ... | 1994 | 8175336 |
| periodontal diseases in hiv-infected patients. | periodontal diseases may be the first clinical sign of human immunodeficiency virus (hiv)-infection. since the immunosuppression and subsequent susceptibility may alter the responses of the oral tissues as well as the microflora, both periodontal treatment and result of therapy may be modified. the periodontal diseases in hiv-seropositive patients include common as well as less conventional forms of gingivitis and periodontitis, and bacterial, mycotic and viral infections are seen. neoplasias ma ... | 1994 | 8195444 |
| histopathology of human immunodeficiency virus-associated esophageal disease. | we evaluated the histopathologic features of the esophageal mucosa in 88 patients seropositive for human immunodeficiency virus (hiv). all patients had an upper endoscopy because of esophageal symptoms. forceps biopsies and brushings of the esophagus were examined histologically and cytologically for evidence of viral, fungal, and mycobacterial infections: in addition, biopsies and brushings were cultured for cytomegalovirus and herpes simplex. esophageal inflammation (acute or chronic) was grad ... | 1993 | 8204115 |
| [cardiac tamponade and kaposi's sarcoma]. | the case of a 31 year-old intravenous drug addict female patient with infection by the human immunodeficiency virus who had recurrent cardiac tamponade and who was diagnosed by pericardic biopsy as kaposi's sarcoma is reported. the patient demonstrated involvement by cutaneous, mucosal, lymph node and probably pleuropulmonary kaposi's sarcoma. thoracic radiography, computerized tomography and echocardiography only showed the presence of pericardic effusion. neither did the pericardic fluid obtai ... | 1994 | 8208010 |
| detection of human immunodeficiency virus type 1 and human papillomavirus type 16 in acquired immunodeficiency syndrome-related and classic kaposi's sarcoma. | | 1993 | 8250588 |
| radiation therapy in endemic (african) kaposi's sarcoma. | evaluating the role of radiation therapy in the treatment of the endemic, african variant of kaposi's sarcoma. a retrospective analysis. | 1993 | 8262845 |
| mycoplasma penetrans infection in male homosexuals with aids: high seroprevalence and association with kaposi's sarcoma. | antibodies to mycoplasma penetrans were found at an unusually high frequency in male homosexuals with aids (55 of 149; 37%) and in human immunodeficiency virus (hiv)-infected asymptomatic homosexuals (13 of 49; 26.5%) but not in intravenous drug users (3 of 308; 1%) and hemophiliacs (1 of 165; 0.6%) with or without hiv-1 infection. thus, both m. penetrans and kaposi's sarcoma (ks) occur primarily in male homosexuals and rarely in other groups of patients at high risk of aids. among 414 hiv-1-inf ... | 1993 | 8268356 |
| pulmonary manifestations of acquired immunodeficiency syndrome-associated malignancies. | significant progress has been made in the treatment and prophylaxis of human immunodeficiency virus (hiv)-associated infections. as patients with hiv infection live longer, more cases with hiv-associated malignancies are being reported. pulmonary complications of hiv-associated kaposi's sarcoma and non-hodgkin's lymphoma present clinicians with diagnostic and therapeutic challenges. pulmonary involvement with kaposi's sarcoma ranges from 6% to 32%. pulmonary involvement with acquired immunodefic ... | 1993 | 8278681 |
| [bacillary angiomatosis. a pseudoneoplastic infection in aids patients]. | bacillary angiomatosis is a newly recognized pseudoneoplastic vascular disease seen in the setting of human immunodeficiency virus (hiv) infection. the disease is characterized by a cutaneous infection with reddish papules or nodules that are similar to pyogenic granulomas or kaposi's sarcoma in clinical appearance. it is caused by the mildly gram-negative bacillus rochalimaea henselae, which can be identified in tissue sections by means of warthin-starry stain. the historical, clinical, histopa ... | 1993 | 8335458 |
| multiple primary gynecologic neoplasms in a young hiv-positive patient. | immune suppression from human immunodeficiency virus (hiv) infection is frequently associated with the development of certain neoplasms, including kaposi's sarcoma and non-hodgkin's lymphoma. a young patient with a 5-year history of hiv infection was found simultaneously to have invasive carcinoma of the breast, microinvasive carcinoma of the cervix, and intraepithelial neoplasia of the vulva. in view of the early nature of these neoplasms, conservative therapy was utilized; lumpectomy and adjuv ... | 1993 | 8393503 |
| clinical manifestations of 174 aids cases in maharaj nakorn chiang mai hospital. | the human immunodeficiency virus (hiv) has, since it was first reported in 1981, become a worldwide epidemic. the immunosuppressive nature of hiv results in opportunistic infections, neoplasms, and other pathological conditions. clinical manifestations of these conditions are often the first indication that an individual is infected with hiv. this article reports and describes the clinical findings for 174 hiv-positive patients and is intended to educate thai physicians concerning the rising ... | 1993 | 8408918 |
| indium-111-labeled polyclonal human immunoglobulin: identifying focal infection in patients positive for human immunodeficiency virus. | pooled human immunoglobulin labeled with indium-111 (111in-higg) was used to identify the presence and extent of infection in patients positive for human immunodeficiency virus (hiv), presenting with either symptoms and/or signs of acute chest infection or with pyrexia without localizing signs or symptoms. fifty-five studies were performed in 51 patients with suspected chest infection or pyrexia without localizing signs. of these, 111in-higg identified intrapulmonary accumulation in 17 patients ... | 1993 | 8410271 |
| esophageal disease in aids is associated with pathologic processes rather than mucosal human immunodeficiency virus type 1. | twenty-five patients with aids and esophageal symptoms were evaluated for the presence of esophageal disease and human immunodeficiency virus type 1 (hiv-1) in the esophageal mucosa. a single infectious process caused by candida albicans, cytomegalovirus, herpes simplex virus, varicella-zoster virus, or mycobacterium avium-intracellulare complex or a single noninfectious process caused by kaposi's sarcoma or reflux esophagitis was identified in 20 patients. two processes were identified in 5 pat ... | 1993 | 8440925 |
| bowenoid changes in kaposi's sarcoma. | previous reports have documented the coexistence of multiple infectious organisms or kaposi's sarcoma within the same biopsy specimens of mucocutaneous lesions in human immunodeficiency virus- (hiv) infected patients. | 1993 | 8454785 |
| acquired immunodeficiency syndrome-like illness associated with systemic mycoplasma fermentans infection in a human immunodeficiency virus-negative homosexual man. | a 35-year-old homosexual man developed a composite nodal kaposi's sarcoma and peripheral t-cell lymphoma that were associated with a peripheral blood cd4-positive lymphocyte count of only 43/mm3. the patient subsequently developed pneumocystis carinii pneumonitis and eventually died due to disseminated cryptococcus neoformans. numerous premortem tests for the presence of human immunodeficiency virus (hiv) types 1 and 2 were negative by the enzyme-linked immunosorbent assay, western blot, viral i ... | 1993 | 8491493 |
| kaposiform hemangioendothelioma of infancy and childhood. an aggressive neoplasm associated with kasabach-merritt syndrome and lymphangiomatosis. | we report the clinical and pathological features of nine distinctive, but relatively unknown, vascular tumors of infancy and childhood presenting as soft tissue masses often associated with locally aggressive disease, lymphangiomatosis and kasabach-merritt syndrome. the patients, four males and five females, were all in their first decade of life except for two (median, 2 years; range, 5 months to 19 years). these tumors involved deep soft tissues of the upper extremity (four cases), retroperito ... | 1993 | 8494101 |
| influence of hiv epidemic on the incidence of kaposi's sarcoma in zambian children. | acquired immunodeficiency syndrome-associated kaposi's sarcoma (ks) is well documented in adults. however, very little information is available about ks in the pediatric age group. a retrospectively study was undertaken at the university teaching hospital (uth), lusaka, zambia, to define the incidence and clinical profile of ks in zambian children over the last 13 years and to determine the influence, if any, of the current human immunodeficiency virus (hiv) epidemic on the pattern of pediatric ... | 1995 | 8548353 |
| kaposi's sarcoma on a lymphedematous arm after mastectomy. | two patients with kaposi's sarcoma developing in an area of lymphedematous arm postmastectomy are reported. the kaposi's sarcoma occurred after latent periods of 26 and 7 years following radical and modified-radical mastectomy, respectively, in the edematous tissue of the ipsilateral arm. the cutaneous nodules were purple in color and ranged in size from a few millimeters to > 1 cm in diameter. the results of routine laboratory tests were all within normal limits. human immunodeficiency virus (h ... | 1996 | 8554044 |
| [kaposi's sarcoma in dermatology consultations at lome, togo]. | the purpose of this retrospective study conducted in a dermatologic out patient clinic in lomé was to assess the epidemiologic, clinical, and prognostic profile of kaposi's sarcoma in togo during the 15 years period between 1980 and 1994. only patients who had undergone serologic tests for human immunodeficiency virus (hiv) were included. there were 30 patients (27 men and 3 women) with a mean age of 35.2 years (range: 17 to 59 years). thirteen patients were seropositive (epidemic kaposi's sarco ... | 1995 | 8559021 |
| human herpesvirus-8 dna sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity. | human herpesvirus-8 (hhv-8) dna sequences have been reported to be strictly associated not only with various forms of kaposi's sarcoma but also with an unusual subgroup of acquired immunodeficiency syndrome (aids)-related b-cell lymphomas. a possible relation of this putative virus also with multicentric castleman's disease (mcd) has been recently suggested. we used polymerase chain reaction to look for the presence of hhv-8 sequences in a well characterized series of benign, atypical, and malig ... | 1996 | 8611719 |
| cutaneous cryptococcus infection and aids. report of 12 cases and review of the literature. | cryptococcal infections occur in 6% to 13% of patients with acquired immunodeficiency syndrome (aids), most commonly infecting the central nervous system. cutaneous lesions have been described morphologically as umbilicated papules, nodules, and violaceous plaques and can mimic molluscum contagiosum and kaposi's sarcoma. cutaneous lesions can present months prior to other signs of systemic infection. | 1996 | 8624151 |
| frequency and distribution of herpesvirus-like dna sequences (kshv) in different stages of classic kaposi's sarcoma and in normal tissues from an italian population. | the frequency and distribution of herpesvirus-like dna sequences (kshv) were investigated by pcr in the pathologic skin lesions of a series of 22 hiv-negative elderly patients with classic kaposi's sarcoma (ks) from italy, one of the few regions of the world where classic ks is prevalent. viral sequences were clearly identifiable in 15 cases, in particular in 2 of 5 patch, in 3 of 6 plaque and in 10 of 11 nodular lesions. our findings confirm the association of these herpesvirus-like dna sequenc ... | 1996 | 8635855 |
| combination chemotherapy with doxorubicin, bleomycin, and vindesine for aids-related kaposi's sarcoma. | kaposi's sarcoma is the most common neoplasm in patients with human immunodeficiency virus (hiv) infection. although the best therapeutic approach is still unclear, patients with advanced ks are usually treated with systemic chemotherapy. | 1996 | 8640679 |
| herpesvirus-like dna sequences and kaposi's sarcoma: relationship with epidemiology, clinical spectrum, and histologic features. | the evidence of an infectious agent other than human immunodeficiency virus (hiv) acting as a possible etiologic cause of kaposi's sarcoma (ks) has received considerable attention in the last years. recently, dna sequences from a new herpesvirus (hhv-8) have been observed in several cases of ks. the discovery suggests that this virus may play a role in the pathogenesis of ks. to evaluate these results, we determined the frequency of hhv-8 dna sequences in 78 specimens of ks according to differen ... | 1996 | 8640682 |
| human herpesvirus-8/kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects b cells. | herpesviral dna fragments isolated from aids-associated kaposi's sarcoma (ks) tissue (kshv-dna) share homology with two lymphotropic oncogenic gamma-herpesviruses, epstein-barr virus and herpesvirus saimiri, and are present in the lesions of more than 95% of hiv and non-hiv-associated forms of ks, aids-related body cavity-based lymphomas, and aids-related multicentric castleman's disease. here we show that bc-1, a kshv-dna-positive, body cavity-based lymphoma cell line, produces infective herpes ... | 1996 | 8642350 |
| use of antiherpes drugs and the risk of kaposi's sarcoma: data from the multicenter aids cohort study. | to determine if use of antiherpes drugs protects against the development of aids-associated kaposi's sarcoma (ks), data from 935 homosexual men with aids from the multicenter aids cohort study were analyzed. in nested case-control analysis, neither acyclovir use for human immunodeficiency virus infection (odds ratio [or], 0.84; 95% confidence interval [ci], 0.56-1.26; p = .39) nor acyclovir use for any indication (or, 1.02; 95% ci, 0.76-1.38; p = .89) was associated with a reduced risk of ks as ... | 1996 | 8648224 |
| [differential radiologic diagnosis of hiv-associated lung diseases]. | in 1993 in germany an estimated number of 50,000-70,000 individuals were infected with the human immunodeficiency virus (hiv), who estimations ranged up to 14 million hiv-positive individuals including 1 million children. aids-related diseases frequently occur in the lung. 65% of all aids-defining illnesses begin with life-threatening pulmonary infections. most frequently hiv-positive patients present with pneumocystis carinii pneumonia, followed by atypical mycobacteriosis, bacterial infections ... | 1995 | 8653002 |
| aids-related conditions: study of a representative sample of 1203 patients deceased in 1992 in france. | little representative information exists on the frequency of human immunodeficiency virus (hiv)-related diseases among the overall aids population. the objective of this research is to assess the nature, frequency and characteristics of these diseases among aids patients during their last year of life and to analyse these frequencies according to the mode of transmission and other socio-demographic and medical characteristics. | 1996 | 8666489 |
| kaposi's sarcoma-associated herpesvirus in non-aids related lymphomas occurring in body cavities. | dna sequences belonging to the recently discovered kaposi's sarcoma-associated herpesvirus (kshv), now provisionally designated human herpesvirus 8, have been previously identified in an uncommonly occurring subset of aids-related lymphomas, referred to as body-cavity-based lymphomas (bcbls), which present as lymphomatous effusions. pyothorax-associated lymphomas (pals) are non-hodgkin's lymphomas that arise in the pleural cavity after long-standing pleural inflammation resulting from therapeuti ... | 1996 | 8686762 |
| primary effusion lymphoma: a distinct clinicopathologic entity associated with the kaposi's sarcoma-associated herpes virus. | we recently discovered the kaposi's sarcoma-associated herpes virus (kshv/hhv-8) in an uncommon and unusual subset of aids-related lymphomas that grow mainly in the body cavities as lymphomatous effusions without an identifiable contiguous tumor mass. the consistent presence of kshv and certain other distinctive features of these body cavity-based lymphomas suggest that they represent a distinct entity. we tested this hypothesis by investigating 19 malignant lymphomatous effusions occurring in t ... | 1996 | 8695812 |
| kaposi's sarcoma (ks)-associated herpesvirus-like dna sequences in peripheral blood mononuclear cells: association with ks and persistence in patients receiving anti-herpesvirus drugs. | herpesvirus-like dna sequences (kshv/hhv-8) have recently been described in aids-associated kaposi's sarcoma (ks) lesions. many questions remain regarding the role of this virus in ks and the therapeutic implications of this finding. in the current study, kshv/hhv-8 dna was detected in peripheral blood mononuclear cells (pbmcs) from human immunodeficiency virus (hiv)-infected patients with ks (34/98) more often than in hiv-infected individuals without ks (12/64, p = .03). the detection of kshv/h ... | 1996 | 8704186 |
| the seroepidemiology of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus): distribution of infection in ks risk groups and evidence for sexual transmission. | striking differences in kaposi's sarcoma (ks) risk for aids patients who acquire hiv via homosexual activity and those whose hiv infections derive from blood product exposure suggest the presence of a sexually transmitted agent other than hiv in the development of ks. using an immunofluorescence assay, we examined serum samples from 913 patients for the presence of antibody specific for infection by human herpesvirus 8 (hhv8), an agent whose genome is regularly found in ks tissue. the distributi ... | 1996 | 8705863 |
| human herpesvirus-8 in aids-related and unrelated lymphomas. | | 1996 | 8724048 |
| acute myelocytic leukaemia associated with kaposi's sarcoma in a patient without serum antibodies to human immunodeficiency virus type 1. | we report a 35-year-old man with acute myelocytic leukaemia and kaposi's sarcoma, whose serum was non-reactive for antibodies to human immunodeficiency virus type-1 by enzyme-linked immunosorbent assay, western blot and immunofluorescence. complete remission of both the acute leukaemia and the kaposi's sarcoma followed treatment with mitoxantrone and cytosine arabinoside. we speculate that the rapid regression of the lesions of kaposi's sarcoma might be related to mitoxantrone and to the return ... | 1996 | 8731687 |
| the lung in hiv infection: can pulmonary function testing help? | simple lung function tests have been used to evaluate respiratory symptoms in human immunodeficiency virus (hiv) infected individuals. abnormalities of simple lung function tests, in particular decreases in the transfer factor of the lung for carbon monoxide (tl,co) have been described in patients with acquired immune deficiency syndrome (aids) who have respiratory disease. early studies showed marked reductions in tl,co in patients with pneumocystis pneumonia but other forms of pulmonary infect ... | 1996 | 8766197 |
| antibodies to human herpesvirus type 8 in the general population and in kaposi's sarcoma patients. | much of the evidence that human herpesvirus type 8 (hhv-8) is associated with kaposi's sarcoma (ks) has come from molecular studies of hhv-8 dna. seroepidemiological studies have been hampered by the lack of a reliable assay. | 1996 | 8826812 |
| kaposi's sarcoma-associated herpesvirus infection prior to onset of kaposi's sarcoma. | kaposi's sarcoma-associated herpesvirus (kshv), a newly discovered human gammaherpesvirus, is found in the majority of ks lesions from patients with and without aids. peripheral blood mononuclear cells (pbmc) were examined for kshv dna to determine whether viral infection precedes onset of this neoplasm. | 1996 | 8838705 |
| establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (bc-3) harboring kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in the absence of epstein-barr virus. | the recently identified kaposi's sarcoma-associated herpesvirus (kshv), also known as human herpesvirus 8 (hhv-8), has been found to be consistently associated with an unusual subset of acquired immunodeficiency syndrome-related lymphomas, the so-called body cavity-based lymphomas (bcbl) or primary effusion lymphomas (pel). these lymphomas are characterized by a unique spectrum of morphologic and molecular characteristics, and grow as lymphomatous effusions without an identifiable contiguous tum ... | 1996 | 8839859 |
| detection of herpesvirus-like dna in the bronchoalveolar lavage fluid of patients with pulmonary kaposi's sarcoma. | pulmonary involvement is a clinically important form of visceral kaposi's sarcoma in immunocompromised patients. recently, herpesvirus-like deoxyribonucleic acid (dna) sequences, defining a new herpesvirus termed "human herpesvirus 8" (hhv8) or "kaposi's sarcoma-associated herpesvirus" (kshv), were detected in kaposi's sarcoma of acquired immune deficiency syndrome (aids) and non-aids patients. we describe the successful detection of hhv8 dna in the bronchoalveolar lavage (bal) fluid of patients ... | 1996 | 8866603 |
| human immunodeficiency virus infection and acquired immunodeficiency syndrome among north american women. | women constitute the fastest growing segment of adults with acquired immunodeficiency syndrome (aids), representing 18% of all cases in the united states in 1994. heterosexual transmission is now the dominant route by which women are infected. recent reports indicate that although certain manifestations may be different in women than in men, the rate of clinical progression is similar when they receive comparable medical treatment. antiretroviral therapy is equally as effective in women as in me ... | 1996 | 8873494 |
| oncological problems in aids--a review of the clinical features and management. | since the beginning of the acquired immunodeficiency syndrome (aids) epidemic in the early 1980s, several malignant conditions have been recognised to be associated with this syndrome which affect up to 40% of aids patients at some stage of their illness. they include kaposi's sarcoma, systemic non-hodgkin's lymphoma, primary central nervous system lymphoma and invasive cervical cancer. kaposi's sarcoma and primary central nervous system lymphoma were tumours rarely seen below the age of 50 prio ... | 1996 | 8876905 |
| detection of herpesvirus-like dna by nested pcr on archival skin biopsy specimens of various forms of kaposi sarcoma. | to detect herpesvirus-like dna sequences, defining a new herpesvirus, human herpesvirus 8 (hhv8), in paraffin wax embedded skin biopsy specimens of the various forms of kaposi sarcoma. | 1996 | 8881911 |
| spindle cells isolated from kaposi's sarcoma-like lesions of bkv/tat-transgenic mice co-express markers of different cell types. | to characterize murine spindle cells isolated from kaposi's sarcoma-like skin lesions developed in bk virus (bkv)/tat-transgenic mice. | 1996 | 8883582 |
| kaposi's sarcoma: relationship to a novel herpesvirus and advances in therapy. | | 1996 | 8883626 |
| changing seroepidemiology of hhv-8. | | 1996 | 8888158 |
| increases in cd3+cd4-cd8- t lymphocytes in aids patients with disseminated mycobacterium avium-intracellulare complex infection. | human immunodeficiency virus type 1 (hiv-1)-infected persons frequently have increased numbers of t cells bearing the gamma delta t cell receptor for antigen (gamma delta tcr). hiv-1-seropositive patients with < 100 cd4+ cells/mm3 were selected and divided into 9 aids-defining illness groups. the percentages of cd4+, cd8+, or double-negative cd4-cd8- (dn) t cells (most of the latter expressing the gamma delta tcr) for 8 symptomatic groups were compared with those for a reference group of asympto ... | 1996 | 8896497 |
| multicentric castleman's disease in hiv infection: a clinical and pathological study of 20 patients. | to describe, in a retrospective study, the clinical and pathological spectrum of multicentric castleman's disease (mcd) in hiv infection. | 1996 | 8924253 |
| kaposi's sarcoma-associated herpesvirus in kaposi's sarcoma occurring in immunosuppressed renal transplant recipients. | kaposi's sarcoma-associated herpesvirus (kshv) has been implicated in the genesis of kaposi's sarcoma and other tumors occurring in immunosuppressed individuals. using amplification by the polymerase chain reaction and nucleotide sequencing of extracted dna, we have detected the ks330(233) sequence of kshv dna in kaposi's sarcoma tissue from 4 immunosuppressed renal transplant recipients. the sequences shared a greater than 98% homology with those described in kshv dna from kaposi's sarcoma in p ... | 1996 | 8930456 |
| the sex ratio of aids-associated kaposi's sarcoma does not provide evidence that sex hormones play a role in pathogenesis. | | 1996 | 8931798 |
| kaposi's sarcoma: evaluation of the role of human papillomaviruses. a study using the high sensitivity hot-start polymerase chain reaction detection method and a review of the literature. | | 1996 | 8950462 |
| kaposi's sarcoma and hhv-8. | | 1996 | 8950809 |
| hhv-8 serology and kaposi's sarcoma. | | 1996 | 8950901 |
| absence of herpesvirus in aids-associated smooth-muscle tumors. | | 1996 | 8965873 |