Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| comparison of serologic assays and pcr for diagnosis of human herpesvirus 8 infection. | a variety of assays for the diagnosis human herpesvirus 8 (hhv-8) infection have been reported. we compared several such assays with a panel of 88 specimens from human immunodeficiency virus (hiv)-infected patients with kaposi's sarcoma (ks) (current-ks patients; n = 30), hiv-infected patients who later developed ks (later-ks patients; n = 13), hiv-infected patients without ks (no-ks patients; n = 25), and healthy blood donors (n = 20). pcr assays were also performed with purified peripheral blo ... | 2000 | 10834972 |
| interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of kaposi's sarcoma. | to determine kaposi's sarcoma (ks) risk related to timing of human immunodeficiency virus type 1 (hiv-1) and human herpesvirus type 8 (hhv-8) infections, stored longitudinal sera from 400 homosexual men with known dates of hiv-1 seroconversion (+/-4.5 months) were tested for hhv-8 antibody. times from hhv-8 seroconversion to ks were compared for the 69 men who became infected with hhv-8 after acquiring hiv-1 to the 182 men who were hhv-8 seropositive before their hiv-1 infection. none developed ... | 2000 | 10837173 |
| high prevalence of epstein-barr virus type 2 among homosexual men is caused by sexual transmission. | to investigate whether epstein-barr virus (ebv) type 2 infection is highly prevalent among homosexual men, the prevalence of ebv type 2 was studied among homosexual and heterosexual white men who were at high and low risk for sexually transmitted diseases; these data were correlated with sexual behavior. the prevalence of ebv type 2 among homosexual men was significantly higher than it was among heterosexual men (39% vs. 6%). among high-risk heterosexual men, prevalence was significantly higher ... | 2000 | 10837190 |
| selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene orf74. | open reading frame 74 (orf74) encoded by human herpesvirus 8 is a highly constitutively active seven transmembrane (7tm) receptor stimulated by angiogenic chemokines, e.g. growth-related oncogene-alpha, and inhibited by angiostatic chemokines e.g. interferon-gamma-inducible protein. transgenic mice expressing orf74 under control of the cd2 promoter develop highly vascularized kaposi's sarcoma-like tumors. through targeted mutagenesis we here create three distinct phenotypes of orf74: a receptor ... | 2000 | 10842179 |
| kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis. | primary amyloidosis (al), like multiple myeloma (mm), results from a clonal proliferation of plasma cells. recent detection of kaposi's sarcoma-associated herpesvirus (kshv) gene sequences in mm patients, although controversial, suggested that kshv may also be present in al. in the present study, we assayed for kshv gene sequences in patients with primary al independently in 2 laboratories. nested polymerase chain reaction (pcr) was performed on dna isolated from 21 bone marrow (bm) core biopsy ... | 2000 | 10842716 |
| absence of herpesvirus dna sequences in the 5t murine model of human multiple myeloma. | kaposi's sarcoma-associated herpesvirus (kshv, also known as hhv-8) has been found in patients with multiple myeloma (mm) and postulated to be aetiologically associated with the development of this common plasma cell malignancy. a murine model of mm was previously established in which intravenous transfer of 5t myeloma cells into c57bl/kalwrij mice resulted in characteristic features of human mm. in the present study, we sought to identify herpesvirus dna sequences in this murine model of mm thr ... | 2000 | 10848833 |
| human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells. | human herpes virus-8 (hhv8) encodes a cytokine named viral interleukin-6 (vil-6) that shares 25% amino-acid identity with its human homologue. human il-6 is known to be a growth and differentiation factor of lymphatic cells and plays a potential role in the pathophysiology of various lymphoproliferative diseases. vil-6 is expressed in hhv8-associated-diseases including kaposi's sarcoma, body-cavity-based-lymphoma and castleman's disease, suggesting a pathogenetic involvement in the malignant gro ... | 2000 | 10848977 |
| spontaneously regressed kaposi's sarcoma and human herpesvirus 8 infection in a human immunodeficiency virus-negative patient. | kaposi's sarcoma occurring in a 78-year-old woman, with the absence of the human immunodeficiency virus infection, was correctly diagnosed by immunohistochemistry using anti-human herpesvirus 8 (hhv8) antibody (pa1-73n) for the first time. the patient suffered from chronic respiratory failure and was treated with a low dose of steroids for 2.5 years. after her medication dosage was increased for the exacerbation of the respiratory failure, multiple skin tumors in her feet and legs suddenly devel ... | 2000 | 10849322 |
| human herpesvirus 8 infection of the genital tract of hiv-seropositive and hiv-seronegative women at risk of sexually transmitted diseases. canadian women's hiv study group. | 2000 | 10853998 | |
| human herpesvirus-8-associated disseminated angiosarcoma in an hiv-seronegative woman: report of a case and limited case-control virologic study in vascular tumors. | 2000 | 10856415 | |
| clinical management of selected oral fungal and viral infections during hiv-disease. | the purpose of this review is to describe current possibilities of management of selected fungal and viral oral opportunistic infections including oral candidiasis, herpes simplex type 1 and 2-related lesions (hsv1,2), oral hairy leukoplakia (ohl) and oral lesions associated with human papilloma viruses (hpv). less common diseases such as cytomegalovirus infection or human herpes virus type 8 associated with kaposi's sarcoma and others are not considered. in a number of instances lifelong therap ... | 1999 | 10858761 |
| immunomodulatory therapy in the management of viral infections in patients with hiv infection. | human immunodeficiency virus (hiv) causes disease by infecting lymphocytes and progressively destroying critical regulatory and effector cells of the immune system, leaving patients vulnerable to a number of bacterial, fungal, and viral infections. facial herpes (herpes simplex virus-1 [hsv-1]), genital herpes (hsv-2), herpes zoster (varicella zoster virus), oral hairy leukoplakia (epstein-barr virus), kaposi's sarcoma (hhv-8), molluscum contagiosum, condyloma acuminata (human papillomavirus [hp ... | 2000 | 10861104 |
| human herpesvirus 8-encoded interleukin-6 homologue (viral il-6) induces endogenous human il-6 secretion. | we found that human herpesvirus 8-encoded il-6 (vil-6) induced endogenous human il-6 (huil-6) secretion from various cell lines (mt-4, thp-1, u937, raji, and cess) including patients with multicentric castleman's disease. especially, in mt-4 cells, huil-6 was enhanced with vil-6 by 30-fold compared with that of control. in addition, reverse transcriptase-polymerase chain reaction confirmed that vil-6 induced huil-6 expression in mt-4 cells. our novel finding of the huil-6 induction by vil-6 indi ... | 2000 | 10861641 |
| [hhv-8/kshv. i - epidemiological and molecular aspects]. | 2000 | 10863190 | |
| protein synthesis by solid-phase chemical ligation using a safety catch linker. | the native chemical ligation reaction has been used extensively for the synthesis of the large polypeptides that correspond to folded proteins and domains. the efficiency of the synthesis of the target protein is highly dependent on the number of peptide segments in the synthesis. assembly of proteins from multiple components requires repeated purification and lyophilization steps that give rise to considerable handling losses. in principle, performing the ligation reactions on a solid support w ... | 2000 | 10864771 |
| kaposi's sarcoma cells of different etiologic origins respond to hiv-tat through the flk-1/kdr (vegfr-2): relevance in aids-ks pathology. | kaposi's sarcoma (ks) is an hyperplastic lesion whose main histological features are typical spindle shaped cells with a mixed endothelial-mesenchymal-macrophage phenotype, an intense vascularization and an inflammatory infiltrate. the etiology of ks appears to be linked to activation of a latent hhv8 infection. sporadic and iatrogenic ks are slow progressing lesions that can undergo spontaneous regression. in contrast, ks, which is frequently associated with hiv infection, is found in a highly ... | 2000 | 10873597 |
| detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines. | the human herpesvirus 8 (hhv8/kshv), along with certain other herpesviruses, encodes a gene with cyclin homology. although the functional significance of the encoded cyclin is not clear at present, various lines of evidence propose a role for this cyclin in latently infected cells and possibly in the induction of tumors that arise in hhv8-infected individuals. we provide evidence here that the cyclin protein is expressed in hhv8 positive primary effusion lymphoma (pel)-derived cell lines and tha ... | 2000 | 10873769 |
| transfusion-associated infections with cytomegalovirus and other human herpesviruses. | of all human herpesviruses, human cytomegalovirus (hcmv) is the most significant cause of transfusion-associated (ta) morbidity and mortality. the problem of ta hcmv infection differs from that of other transfusion-transmitted infections in that only certain groups of patients require hcmv-free blood or blood components, i.e. seronegative pregnant women, premature infants of low birth weight who are born to seronegative mothers, seronegative recipients of allogeneic bone marrow transplants from ... | 2000 | 10878482 |
| inhibition of intracellular transport of b cell antigen receptor complexes by kaposi's sarcoma-associated herpesvirus k1. | the b cell antigen receptor (bcr) is a large complex that consists of a disulfide-linked tetramer of two transmembrane heavy (mu) chains and two light (lambda or kappa) chains in association with a heterodimer of igalpha and igbeta. kaposi's sarcoma-associated herpesvirus (kshv) encodes a transforming protein called k1, which has structural and functional similarity to igalpha and igbeta. we demonstrate that k1 downregulates the expression of bcr complexes on the surface. the nh(2)-terminal regi ... | 2000 | 10880522 |
| localisation of hhv-8 in aids related lymphadenopathy. | many lymph node abnormalities have been described in aids. these include opportunistic infections that sometimes result in spindle cell pseudotumours, kaposi's sarcoma (ks), malignant lymphoma (hodgkin's and non-hodgkin's), and florid reactive hyperplasia. among these, reactive hyperplasia is the most common manifestation of aids related lymphadenopathy. | 2000 | 10884921 |
| the restricted cellular host range of human herpesvirus 8. | a selection of primary and transformed cell types were evaluated for their susceptibility to infection with human herpesvirus 8 (hhv-8)/kaposi's sarcoma-associated herpesvirus. | 2000 | 10894276 |
| on the control of late gene expression in kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). | herpesvirus late genes require viral dna replication for maximal expression. although late gene expression appears to require dna replication in cis in alphaherpesviruses, studies in epstein-barr virus (ebv) suggest that this cis-requirement might not pertain to the gammaherpesviruses. based on these findings, a system was created to investigate the elements required for the regulation of kaposi's sarcoma-associated herpesvirus (kshv; human herpesvirus-8) late gene expression. the transcript of ... | 2000 | 10900043 |
| human herpes virus-8 associated with two cases of primary-effusion lymphoma. | primary-effusion lymphoma (pel) is a rare form of non-hodgkin's lymphoma which predominantly occurs in patients with acquired immunodeficiency syndrome and is characterized by the presence of a malignant effusion in one or more of the body cavities, generally in the absence of a primary tumor mass. recently, we encountered two cases of pel presenting as cardiac tamponade. in both cases, a diagnosis of diffuse large b-cell lymphoma was made by examination of the pericardial fluid. because human h ... | 2000 | 10901615 |
| treatment of nonmelanotic hyperpigmentation with the q-switched ruby laser. | hyperpigmentation of the skin is often refractory to conventional therapies, but has significant cosmetic implications if located on visible areas. because laser systems are capable of removing pigment deposits caused by selective photothermolysis, we addressed the issue of whether the q-switched ruby laser could be a useful alternative in the treatment of nonmelanotic hyperpigmented skin lesions. we report the successful treatment of a patient with hyperpigmentation caused by iatrogenic human h ... | 2000 | 10906650 |
| characterization of a novel hhv-8-positive cell line reveals implications for the pathogenesis and cell cycle control of primary effusion lymphoma. | primary effusion lymphoma (pel) represents a peculiar type of b cell lymphoma which associates with hhv-8 infection and preferentially grows in liquid phase in the serous body cavities. in this report, we provide the detailed characterization of a newly established pel cell line, termed cro-ap/6. the cell line was obtained from the pleural effusion of a hiv-positive patient with pel. its derivation from the tumor clone was established by immunogenotypic analysis. detailed phenotypic investigatio ... | 2000 | 10914556 |
| cd19+ and cd20+ b cells from the peripheral blood of patients with multiple myeloma are not infected with human herpesvirus 8. | 2000 | 10914566 | |
| no evidence of active infection with human herpesvirus 6 (hhv-6) or hhv-8 in chronic fatigue syndrome. | 2000 | 10917774 | |
| decreased immunoreactivity for cell-cycle regulator p27(kip1) in kaposi's sarcoma correlates with higher stage and extracutaneous involvement. | a consistent relationship has been established between the development of kaposi's sarcoma (ks) and human herpes virus-8 (hhv8) infection. hhv8-encoded v-cyclin, through its complexing with cyclin-dependent kinase 6, contributes to the phosphorylation and proteasome-mediated degradation of p27(kip1). on the other hand, down-regulation of p27(kip1) expression seems to facilitate metastatic dissemination in a variety of human neoplasms. although the neoplastic nature of ks remains controversial, i ... | 2000 | 10918213 |
| a case of classic kaposi's sarcoma in a japanese man: detection of human herpes virus 8 (hhv-8) infection by means of polymerase chain reaction and immunofluorescence assay. | the recently discovered human herpes virus 8 (hhv-8) has been implicated in the pathogenesis of kaposi's sarcoma (ks). because classic ks in japan is rare and the detection of hhv-8 dna by polymerase chain reaction (pcr) has been successful only in limited cases, the frequency and role of hhv-8 infection in ks in japan remain unclear. herein we report a case of classic ks in a japanese man whose hhv-8 infection was confirmed by the detection of lesional viral dna and serum antibodies against lyt ... | 2000 | 10920585 |
| impaired ctl recognition of cells latently infected with kaposi's sarcoma-associated herpes virus. | kaposi's sarcoma-associated herpes virus (kshv) is a recently identified human gamma2-herpesvirus associated with kaposi's sarcoma, primary effusion lymphoma, and castleman's disease. we reasoned that ctl responses may provide host defense against this virus, and consequently, kshv may have evolved strategies to evade the ctl-mediated immune surveillance. in this study six b cell lines latently infected with kshv were found to express reduced levels of hla class i surface molecules compared with ... | 2000 | 10925292 |
| primary infection with human herpesvirus 8 in an hiv-1-infected patient. | 2000 | 10930174 | |
| does hhv-8 have a neuroprotective role on the development of hiv encephalopathy? | 2000 | 10932300 | |
| absence of immunohistochemical evidence for human herpesvirus 8 (hhv8) in oral cavity plasmablastic lymphoma in an hiv-positive man. | 2000 | 10942339 | |
| selenium and interleukins in persons infected with human immunodeficiency virus type 1. | an important role for selenium in human immunodeficiency virus (hiv) disease has been proposed. decreased selenium levels, as found in persons with hiv infection or aids, are sensitive markers of disease progression. selenium deficiency, an independent predictor of mortality in both hiv-1-infected adults and children, is an essential micronutrient that is associated with an improvement of t cell function and reduced apoptosis in animal models. in addition, adequate selenium may enhance resistanc ... | 2000 | 10944486 |
| the role of human immunodeficiency virus-i in the pathogenesis of acquired immunodeficiency syndrome-related kaposi's sarcoma: the importance of an inflammatory and angiogenic milieu. | people infected with human immunodeficiency virus type-i (hiv-i) have an increased incidence of kaposi's sarcoma (ks) and hiv-i infection alters the natural history of ks. the potent trans-activator hiv-i protein tat plays a major role in the pathogenesis of acquired immunodeficiency syndrome (aids)-related ks. among many of its ks-promoting activities, the tat protein augments the angiogenic activities of basic fibroblast growth factor (bfgf), interferon gamma, and vascular endothelial growth f ... | 2000 | 10950368 |
| new therapies for the treatment of aids-related kaposi sarcoma. | kaposi sarcoma (ks) is the most common tumor arising in hiv-infected patients and is an aids-defining illness by the centers for disease control guidelines. the clinical course of aids-related ks is highly variable, ranging from minimal stable disease to explosive growth. recent advances in the elucidation of the pathogenesis of ks are uncovering many potential targets for ks therapies. such targets include the processes of angiogenesis and cellular differentiation, sex hormones, and the ks herp ... | 2000 | 10975552 |
| kaposi's sarcoma. | 2000 | 10979790 | |
| [primary effusion lymphoma associated with type-8 human herpes virus infection]. | primary effusion lymphoma is an unusual entity and it has been described as a subset associated with human herpes virus 8 infection in homosexual males with aids. its inclusion as a new entity in the revised european-american lymphoma classification has been recommended. the case in which it is presented is a 47-year-old man, diagnosed with aids two years ago, who came with kaposi's sarcoma. nowadays, he has a right pleural effusion and a thoracentesis has been carried out. we obtain 10 ml of ha ... | 2000 | 10981334 |
| seroprevalence of human herpesvirus 8 and its association with kaposi sarcoma in brazil. | epidemiologic studies have indicated that human herpesvirus 8 is implicated in the development of kaposi sarcoma in different geographic areas worldwide. | 2000 | 10987454 |
| human herpesvirus 8 lana interacts with proteins of the msin3 corepressor complex and negatively regulates epstein-barr virus gene expression in dually infected pel cells. | the human herpesvirus 8 (hhv-8) latency-associated nuclear antigen (lana) is expressed in all latently hhv-8 infected cells and in hhv-8-associated tumors, including primary effusion lymphoma (pel). to better understand the contribution of lana to tumorigenesis and to the pel phenotype, we performed a yeast two-hybrid screen which identified the corepressor protein sap30 as a lana binding protein. sap30 is a constituent of a large multicomponent complex that brings histone deacetylases to the pr ... | 2000 | 11000236 |
| kshv-like herpesviruses in chimps and gorillas. | 2000 | 11001045 | |
| long latency of human herpesvirus type 8 infection and the appearance of classic kaposi's sarcoma. | 2000 | 11004646 | |
| herpesviruses 6, 7 and 8 in hiv- and non-hiv-associated periodontitis. | human herpesviruses, especially cytomegalovirus and epstein barr virus type-1, occur with higher frequency in subgingival specimens from periodontitis lesions than from healthy/gingivitis sites. little or no information is available on the relationship between herpesvirus 6 (hhv-6), herpesvirus 7 (hhv-7) and herpesvirus 8 (hhv-8) and periodontal disease. this study determined the periodontal occurrence of hhv-6, hhv-7 and hhv-8 in 21 hiv-seropositive and 14 hiv-negative adults affected by period ... | 2000 | 11005155 |
| kaposi's sarcoma-associated virus mounts novel attack on immune system. | 2000 | 11006519 | |
| human herpesvirus 8 in brazilian amerindians: does vertical transmission play a role? | 2000 | 11023487 | |
| inhibition of p300 histone acetyltransferase by viral interferon regulatory factor. | kaposi's sarcoma-associated herpesvirus (kshv) has been consistently identified in kaposi's sarcomas, body cavity-based lymphomas, and some forms of castleman's disease. the k9 open reading frame of kshv encodes a viral interferon regulatory factor (virf) which functions as a repressor for cellular interferon-mediated signal transduction and as an oncogene to induce cell growth transformation. we demonstrate that kshv virf directly interacts with cellular transcriptional coactivator p300 and dis ... | 2000 | 11027294 |
| human herpesvirus 8 is not associated with sarcoidosis in japanese patients. | the etiology of sarcoidosis remains unknown, but recently it was reported that human herpesvirus 8 (hhv-8) may be detected in sarcoid tissue in a high proportion of patients. this study was performed to determine whether hhv-8 is implicated in sarcoidosis in japan. | 2000 | 11035657 |
| constitutive signaling of the human cytomegalovirus-encoded chemokine receptor us28. | previously it was shown that the hhv-8-encoded chemokine receptor orf74 shows considerable agonist-independent, constitutive activity giving rise to oncogenic transformation (arvanitakis, l., geras-raaka, e., varma, a., gershengorn, m. c., and cesarman, e. (1997) nature 385, 347-350). in this study we report that a second viral-encoded chemokine receptor, the human cytomegalovirus-encoded us28, also efficiently signals in an agonist-independent manner. transient expression of us28 in cos-7 cells ... | 2001 | 11050102 |
| relationship of human herpesvirus 8 peripheral blood virus load and kaposi's sarcoma clinical stage. | to determine the relationship between human herpesvirus 8 (hhv-8 or kaposi's sarcoma-associated herpesvirus) peripheral blood virus load and kaposi's sarcoma (ks) clinical stage. | 2000 | 11061651 |
| patterns of lymphotropic herpesvirus viraemia in hiv-infected patients with kaposi's sarcoma treated with highly active antiretroviral therapy and liposomal daunorubicin. | 2000 | 11061671 | |
| morphogenesis of hhv8 in primary human dermal microvascular endothelium and primary effusion lymphomas. | this study elucidates the morphology of hhv8 replication in human dermal endothelial cells and primary effusion lymphomas (pel) and compares it to that seen in kaposi sarcoma. primary human dermal microvascular endothelial cells (dmvec) exposed to the cell-filtered supernatant of the pel jsc1 and pel cell lines (ks-1, bcbl-1, bc-1, bc-3) were cultured in the presence or absence of 12-o-tetradecanoyl-phorbol-13-acetate (tpa) or butyrate. cells were fixed in neutral-buffered glutaraldehyde, gelled ... | 2000 | 11071567 |
| human herpes virus 8 and kaposi's sarcoma: a review. | kaposi's sarcoma (ks) was first described one century ago as a disease occurring in elderly men manifested as an indolent cutaneous form. after the onset of human immunodeficiency virus type i (hiv-1) infection, ks became epidemic which, in association with hiv, presented as an aggressive, systemic disease. recently, the recognition that a novel human herpes virus-8 (hhv-8) was highly prevalent among ks patients provided strong evidence to indicate that hhv-8 was the etiology of ks. the pathogen ... | 1999 | 11084663 |
| human herpesvirus 8 infections. | human herpesvirus 8 (hhv-8) or kaposi's sarcoma (ks)-associated herpesvirus is a recently identified virus that is associated with ks, multicentric castleman's disease, and body cavity-based lymphomas. ks is the most common kind of cancer in aids patients and the initial aids-defining condition in over 20% of patients. hhv-8 dna has now been detected in over 95% of ks tissue samples supporting the concept that hhv-8 has a causal role in ks. the discovery has opened new avenues for understanding ... | 1999 | 11095800 |
| unusual presentation of "extracavitary" primary effusion lymphoma in previously unknown hiv disease. | human herpes virus, type 8, also called kaposi's sarcoma-associated virus, is associated with primary effusion lymphoma, an uncommon and unusual subset of acquired immunodeficiency syndrome-related lymphomas mostly confined to body cavities, which primarily affects human immunodeficiency virus-positive men. we report the case of a 40-year-old male with primary effusion lymphoma that presented initially with generalized lymphadenopathy and hepatosplenomegaly, followed by pericardial effusion and ... | 2000 | 11100630 |
| human herpesvirus 8 and oral health care: an update. | the purpose of this report was to review the current literature on human herpesvirus 8 (hhv-8) with particular attention to the aspects of interest for dental health care workers. | 2000 | 11113813 |
| kaposi's sarcoma-associated herpesvirus lana2 is a b-cell-specific latent viral protein that inhibits p53. | kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8, is associated with three proliferative diseases ranging from viral cytokine-induced hyperplasia to monoclonal neoplasia: multicentric castleman's disease (cd), kaposi's sarcoma (ks), and primary effusion lymphoma (pel). here we report a new latency-associated 1,704-bp kshv spliced gene belonging to a cluster of kshv sequences having homology to the interferon regulatory factor (irf) family of transcription factors. orfk10.5 ... | 2001 | 11119611 |
| modulation of cellular and viral gene expression by the latency-associated nuclear antigen of kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv), also called human herpesvirus 8 (hhv-8), is the likely etiological agent of kaposi's sarcoma and primary effusion lymphoma. common to these malignancies is that tumor cells are latently infected with kshv. viral gene expression is limited to a few genes, one of which is the latency-associated nuclear antigen (lana), the product of orf73. examination of the primary sequence of lana reveals some structural features reminiscent of transcription factor ... | 2001 | 11119614 |
| kaposi's sarcoma-like lesions and other nodules as cutaneous involvement in aids-related visceral leishmaniasis. | a 40-year-old human immunodeficiency virus (hiv)-positive man had three relapses of visceral leishmaniasis (vl). in the third he developed nodular skin lesions of three types, some reminiscent of kaposi's sarcoma. biopsy of each type disclosed abundant dermal macrophages with a huge number of intracellular and extracellular leishman-donovan bodies. rapid improvement of lesions was achieved after antiparasitic treatment. aids leads to atypical forms of leishmaniasis. leishmania has been detected ... | 2000 | 11122042 |
| emerging viral infections relevant to transfusion medicine. | the development of new technologies leads to the discovery of new viruses. for each of these new infectious agents relevance to transfusion needs to be assessed. the questions to be answered are transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays. since 1995, three new viruses have been identified and extensively studied. gb virus-c/hepatitis g virus (gbv-c/hgv), a relatively rare virus with some homology with and epide ... | 2000 | 11124105 |
| a chimpanzee rhadinovirus sequence related to kaposi's sarcoma-associated herpesvirus/human herpesvirus 8: increased detection after hiv-1 infection in the absence of disease. | to look for a virus related to kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus 8 (hhv8) in chimpanzees and to investigate phylogenetic and biological similarities to kshv. | 2000 | 11125908 |
| co-receptor use by hiv and inhibition of hiv infection by chemokine receptor ligands. | human and simian immunodeficiency viruses (hiv and siv) require a seven transmembrane chemokine (7tm) receptor in addition to cd4 for efficient entry into cells. ccr5 and cxcr4 act as major co-receptors for non-syncytium-inducing and syncytium-inducing strains respectively. we have examined the co-receptor requirement for hiv-1 infection of cells of macrophage lineage. both ccr5 and cxcr4 can operate as functional co-receptors for infection in these cell types. other co-receptors utilised by mul ... | 2000 | 11138769 |
| mechanistic study on the cytostatic and tumor cell differentiation-inducing properties of 9-(2-phosphonylmethoxyethyl)adenine (pmea, adefovir)-collected publications. | the therapeutic potential of the antiretroviral drug 9-(2-phosphonylmethoxyethyl)adenine (pmea, adefovir) for the treatment of human immunodeficiency virus (hiv)- and human hepatitis b virus (hbv) infections is currently being explored in advanced clinical trials. in the present study, we investigated the impact of pmea on cellular functioning (cell cycle, nucleotide metabolism, nucleic acid synthesis, ...). moreover, we have unraveled the molecular/biochemical basis underlying the marked differ ... | 2000 | 11144686 |
| hiv-associated multinucleated giant cells in lymphoid tissue of the waldeyer's ring: a detailed study. | hyperplastic lymphoid tissues of the waldeyer's ring in human immunodeficiency virus (hiv)-infected patients may occasionally contain multinucleated giant cells (mgcs). these cells, which are unrelated to any opportunistic infection, previously have been demonstrated to harbor significant amounts of hiv. studies undertaken to characterize these mgcs have generated conflicting results: some reports suggested a macrophage origin, whereas others supported a dendritic cell lineage. this study was pe ... | 2000 | 11144925 |
| regression of aids-related kaposi's sarcoma following combined antiretroviral treatment. | the aim of the study was to assess regression of kaposi's sarcoma (ks) in aids patients in argentina. eighteen male aids patients with human immunodeficiency virus (hiv)-associated kaposi's sarcoma at different clinical stages received ks specific treatment and/or anti-retroviral therapy. triple anti-retroviral therapy was given to most of the patients with the exception of four who received zidovudine (zdv) in combination with another nucleoside analogue but no protease inhibitors. plasma viral ... | 2000 | 11149154 |
| genome sequence of bovine herpesvirus 4, a bovine rhadinovirus, and identification of an origin of dna replication. | bovine herpesvirus 4 (bohv-4) is a gammaherpesvirus of cattle. the complete long unique coding region (lur) of bohv-4 strain 66-p-347 was determined by a shotgun approach. together with the previously published noncoding terminal repeats, the entire genome sequence of bohv-4 is now available. the lur consists of 108,873 bp with an overall g+c content of 41.4%. at least 79 open reading frames (orfs) are present in this coding region, 17 of them unique to bohv-4. in contrast to herpesvirus saimiri ... | 2001 | 11152491 |
| activation of kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. | the majority of kaposi's sarcoma-associated herpesvirus (kshv)-infected cells identified in vivo contain latent kshv, with lytic replication in only a few percent of cells, as is the case for the cells of kaposi's sarcoma (ks) lesions. factors that influence kshv latent or lytic replication are not well defined. because persons with ks are often immunosuppressed and susceptible to many infectious agents, including human cytomegalovirus (hcmv), we have investigated the potential for hcmv to influ ... | 2001 | 11152511 |
| detection of lymphotropic herpesvirus dna by polymerase chain reaction in cerebrospinal fluid of aids patients with neurological disease. | cerebrospinal fluid (csf) samples from 49 acquired immunodefficiency disease syndrome (aids) patients with a central nervous system (cns) disease were examined by polymerase chain reaction (pcr) to evaluate the association between the positivity for cytomegalovirus (cmv) and epstein-barr virus (ebv), and clinical diagnosis of a cns disease. frequency and clinical relevance of detection of dna of human herpesviruses 6 (hhv-6), 7 (hhv-7) and 8 (hhv-8) were also determined. dna of one or more of th ... | 2000 | 11155355 |
| kaposi's sarcoma in south africa. | kaposi's sarcoma was endemic in south africa even before the advent of the human immunodeficiency virus (hiv). between 1988 and 1996, the incidence of kaposi's sarcoma in south africa has risen at least threefold and continues to increase as the hiv epidemic grows. research from south africa has shown that infection with human herpesvirus 8 (hhv8) is associated with kaposi's sarcoma but not with any other major cancer site or type. in addition, the risk of kaposi's sarcoma increases with increas ... | 2001 | 11158199 |
| post-transplant lymphoproliferative disorders: implications for acquired immunodeficiency syndrome-associated malignancies. | post-transplant lymphoproliferative disorders (ptlds) comprise a histologic spectrum, ranging from hyperplastic-appearing lesions to frank non-hodgkin's lymphoma or multiple myeloma histology. multiple clones may coexist, each representing a discrete lymphomagenic event, a situation that is unique to immunodeficiency states. the incidence varies from 1% in renal recipients to 5% in heart recipients, but can be markedly increased by the use of anti-t-cell therapies or by t-cell depletion in bone ... | 2001 | 11158205 |
| role of the national cancer institute in acquired immunodeficiency syndrome-related drug discovery. | 2001 | 11158208 | |
| mechanisms governing expression of the v-flip gene of kaposi's sarcoma-associated herpesvirus. | open reading frame 71 (orf 71) of kaposi's sarcoma-associated herpesvirus (kshv) encodes a death effector domain-containing protein that is homologous to cellular flips (flice-inhibitory proteins) and is proposed to inhibit fas-mediated apoptosis. transcripts bearing orf 71 (v-flip) sequences are present in all latently infected cells. however, mapping studies reveal these to be bi- or tricistronic mrnas with orf 71 located 3' to orfs 72 (v-cyclin) and 73 (latency-associated nuclear antigen), ra ... | 2001 | 11160684 |
| kaposi's sarcoma-associated herpesvirus vcyclin open reading frame contains an internal ribosome entry site. | we have previously examined the transcription and splicing of open reading frames (orfs) 71 (k13), 72, and 73 of kaposi's sarcoma-associated herpesvirus (kshv) in the primary effusion lymphoma cell line bcp-1 (latently infected with kshv) (45). the three genes encoded by these orfs (for vflip, vcyclin, and latency-associated nuclear antigen [lana]) are transcribed from a common transcription start site in bcp-1 cells during both latency and the lytic cycles. the resulting transcript is spliced t ... | 2001 | 11160685 |
| structure/function of human herpesvirus-8 mip-ii (1-71) and the antagonist n-terminal segment (1-10). | kaposi's sarcoma-associated herpesvirus encodes a chemokine called vmip-ii that has been shown to be a broad range human chemokine receptor antagonist. two n-terminal peptides, vmip-ii(1-10) and vmip-ii(1-11)dimer (dimerised through cys11) were synthesised. both peptides are shown to bind the cxc chemokine receptor 4 (cxcr4). vmip-ii(1-10) was 1400-fold less potent than the native protein whilst the vmip-ii(1-11)dimer was only 180-fold less potent. in addition, both peptides are cxcr4 antagonist ... | 2001 | 11165244 |
| kaposi's sarcoma, oncogenic viruses, and iron. | iron is required for many cellular processes, but it is also toxic in excess quantities. therefore, iron homeostasis and utilization must be strictly maintained, and defects in iron absorption or transport result in iron depletion or accumulation. most research has been directed to enteral and placental transfer of iron, but little is known about iron entry through the skin. we present evidence that exposure to wet clay soils in africa is an important risk factor for kaposi's sarcoma (ks) and sp ... | 2001 | 11166660 |
| b-lymphotropic viruses in a novel tropical splenic lymphoma. | peripheral blood from patients with a novel tropical splenic lymphoma, characterized by splenomegaly and circulating naïve cd5-negative villous b lymphocytes, has been screened for evidence of an association with the b-lymphotropic viruses, epstein--barr virus (ebv), hepatitis c virus (hcv) and human herpesvirus 8 (hhv8). no increased prevalence of ebv, hcv and hhv8 was demonstrated using serological and molecular techniques, compared with a geographical, age-matched control group. however, lymp ... | 2001 | 11167797 |
| human herpesviruses-6, -7 and -8 in organ transplant recipients. | the newer herpesviruses are being increasingly recognized as significant opportunistic pathogens in organ transplant recipients. published data support the role of human herpesvirus-6 as a potential cause of encephalitis and bone marrow suppression in transplant setting. an association of human herpesvirus-6 with fungal infections and cytomegalovirus infection has also been documented. human herpesvirus-7 also appears to be an immunomodulatory agent and may facilitate the pathogenicity of cytome ... | 2000 | 11168178 |
| identification of a short amino acid sequence essential for efficient nuclear targeting of the kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 k8 protein. | the k8 protein of kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus-8 is a member of the bzip family of transcription factors, which has homology with the epstein-barr virus transcription and replication factor, eb1. in this report, we have analysed the subcellular localization of the k8 protein and characterized a 12 amino acid sequence rich in basic residues which is responsible for targeting the protein to the cell nucleus. furthermore, we show that a k8 mutant lacking the nucl ... | 2001 | 11172091 |
| colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of kaposi's sarcoma and lymphoid cells of multicentric castleman's disease. | human herpesvirus-8 (hhv-8) also called kaposi's sarcoma-associated herpesvirus infects spindle cells in kaposi's sarcoma (ks) and lymphoid cells in multicentric castleman's disease (mcd). in ks cells, hhv-8 is mainly latent with the expression of latent nuclear antigen-1 (lna-1), whereas in mcd both lytic and latent antigens are produced by lymphoid cells. we show by immunohistochemical labeling that in ks viral interleukin-6 (vil-6) is expressed in rare spindle cells, whereas in mcd, vil-6 is ... | 2001 | 11172301 |
| viral exploitation and subversion of the immune system through chemokine mimicry. | the chemokine superfamily of leukocyte chemoattractants coordinates development and deployment of the immune system by signaling through a family of g protein-coupled receptors. the importance of this system to antimicrobial host defense has been supported by the discovery of numerous herpesviruses and poxviruses that encode chemokine mimics able to block chemokine action. however, specific herpesviruses and lentiviruses can also exploit the immune system through chemokine mimicry, for example, ... | 2001 | 11175803 |
| treatment of kaposi's sarcoma. | 2001 | 11191125 | |
| biology of non-hodgkin's lymphoma. | 2001 | 11191126 | |
| non-hodgkin's lymphoma: pathogenesis, clinical presentation, and treatment. | 2001 | 11191128 | |
| the biology of kaposi's sarcoma. | 2001 | 11191137 | |
| [primary effusion lymphoma and other lymphoproliferative diseases associated with hhv-8]. | 2000 | 11198465 | |
| intrafamilial transmission of human herpesvirus 8. | 2001 | 11208891 | |
| internal ribosome entry site regulates translation of kaposi's sarcoma-associated herpesvirus flice inhibitory protein. | the gammaherpesvirus kaposi's sarcoma-associated herpesvirus (kshv) (or human herpesvirus 8) is associated with the endothelial tumor kaposi's sarcoma (ks) and lymphoproliferative disorders in immunocompromised individuals. only a small number of viral proteins are expressed in b cells latently infected with kshv; here we characterize the mechanism of expression of one of these, the viral flice inhibitory protein v-flip (k13, orf71). the v-flip coding region is present in a bicistronic message, ... | 2001 | 11222719 |
| polymerase chain reaction detection of kaposi's sarcoma-associated herpesvirus-optimized protocols and their application to myeloma. | since its discovery in 1994, kshv (also called human herpesvirus-8 or hhv8) has been implicated in a variety of disorders. although the association of kshv with kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman's disease has been well established, its presence in some other diseases, such as multiple myeloma, remains controversial. because most kshv studies are based on polymerase chain reaction (pcr) analysis, the conflicting data may be attributable to variatio ... | 2001 | 11227070 |
| mucosal shedding of human herpesvirus 8. | 2001 | 11229345 | |
| prevalence of kaposi sarcoma-associated herpesvirus compared with selected sexually transmitted diseases in adolescents and young adults in rural rakai district, uganda. | kaposi sarcoma-associated herpesvirus (kshv) is transmitted by routes such as homosexual intercourse and is associated with hiv infection in industrialized countries. however, there is little information about its transmission in developing countries where kaposi sarcoma is an endemic disease. | 2001 | 11234789 |
| biological features of the clone involved in primary amyloidosis (al). | primary light chain-associated amyloidosis (al) is a plasma cell dyscrasia that causes morbidity via systemic tissue deposition of monoclonal light chains in the form of fibrils (amyloid). it is the most common form of systemic amyloidosis in western countries and is rapidly fatal. knowledge of the pathobiology of the underlying b cell clone is of primary importance for the design and optimization of therapeutic strategies. | 2001 | 11236934 |
| kaposi's sarcoma-associated herpesvirus k-bzip protein is phosphorylated by cyclin-dependent kinases. | the k8 locus in kaposi's sarcoma-associated herpesvirus (kshv) is syntenic with the epstein-barr virus (ebv) bzlf (z) locus and expresses three alternatively spliced transcripts. the fully spliced transcript encodes k-bzip, the kshv homologue of the ebv immediate-early transcriptional transactivator z. here we show that despite the presence of alternatively spliced transcripts, the protein from the fully spliced rna, k-bzip, is the principal product detectable in kshv-infected b cells. the prote ... | 2001 | 11238844 |
| human herpes virus-8 infection among pregnant women and their children: results from the sardinia-iddm study 2. | 2001 | 11267990 | |
| primary kaposi sarcoma of the bowel in a hiv-negative patient. | a case of kaposi sarcoma with hiv-negative and sequence of hhv-8 positive and exclusive rectosigmoid and descending colon involvement without immunodeficiency is reported. histologically, in addition to typical features of kaposi sarcoma, cowdry type a inclusions were seen. pcr analysis of the tumor showed positivity for human herpesvirus 8. two of the six reported cases of kaposi sarcoma limited to the bowel were from african men before the aids epidemic. j. surg. oncol. 2001;76:197-200. | 2001 | 11276024 |
| the kaposi's sarcoma-associated herpesvirus g protein-coupled receptor promotes endothelial cell survival through the activation of akt/protein kinase b. | the kaposi's sarcoma-associated herpesvirus g protein-coupled receptor (kshv-gpcr) is a key molecule in the pathogenesis of kaposi's sarcoma, playing a central role in the promotion of vascular endothelial growth factor (vegf)-driven angiogenesis and spindle cell proliferation. we previously have shown that kshv-gpcr has oncogenic potential when overexpressed in fibroblasts and is responsible for the expression and secretion of vegf through the regulation of different intracellular signaling pat ... | 2001 | 11289142 |
| human herpesvirus 8 interaction with target cells involves heparan sulfate. | human herpesvirus 8 (hhv-8) or kaposi's sarcoma associated herpesvirus (kshv) is associated with kaposi's sarcoma and primary effusion lymphoma. in vivo, hhv-8 dna and transcripts have been detected in b cells, endothelial cells, macrophages, and epithelial cells. hhv-8 infects a variety of cell lines of human and animal origin, leading to latent or abortive infection. this study shows that the broad cellular tropism of hhv-8 may be in part due to its interaction with the ubiquitous host cell su ... | 2001 | 11289807 |
| primary human herpesvirus 8 infection generates a broadly specific cd8(+) t-cell response to viral lytic cycle proteins. | human herpesvirus 8 (hhv-8) is a recently discovered gammaherpesvirus that is the etiologic agent of kaposi sarcoma (ks). the natural history of primary hhv-8 infection, including clinical outcome and host immune responses that may be important in preventing disease related to hhv-8, has not been elucidated. the present study characterized the clinical, immunologic, and virologic parameters of primary hhv-8 infection in 5 cases detected during a 15-year longitudinal study of 108 human immunodefi ... | 2001 | 11290599 |
| timing of human immunodeficiency virus type 1 and human herpesvirus 8 infections and length of the kaposi's sarcoma-free period in coinfected persons. | 2001 | 11294681 | |
| the herpesvirus 8-encoded chemokine vmip-ii, but not the poxvirus-encoded chemokine mc148, inhibits the ccr10 receptor. | the viral chemokine antagonist vmip-ii encoded by human herpesvirus 8 (hhv8) and mc148 encoded by the poxvirus - molluscum contagiosum - were tested against the newly identified chemokine receptor ccr10. as the ccr10 ligand eskine / ccl27 had the highest identity to mc148 and because both chemokines are expressed in the skin we suspected mc148 to block ccr10. however, in calcium mobilization assays we found mc148 unable to block ccr10 in micromolar concentrations in contrast to vmip-ii. (125)i-m ... | 2001 | 11298347 |
| acquired immunodeficiency syndrome-associated cancers in sub-saharan africa. | sub-saharan africa is considered home to more than 60% of all human immunodeficiency virus (hiv) infected cases, with an estimated adult prevalence of 8.0%. it is stated that this region has contributed more than 90% of childhood deaths related to hiv infection and about 93% of childhood acquired immunodeficiency syndrome (aids)-related deaths. although no country in africa is spared of the infection, the bulk is seen in east and south africa, with the highest recorded rates of 20% to 50% in zim ... | 2001 | 11301383 |
| detection of kaposi sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. | kaposi sarcoma-associated herpesvirus (kshv) recently has been identified in the bone marrow (bm) dendritic cell of multiple myeloma (mm) patients. however, whether or not kshv is associated with mm remains controversial because many studies have failed to detect the presence of kshv dna sequences in the bm of their mm patients. | 2001 | 11301386 |