Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| human herpesvirus-8 (hhv-8) gene expression in kaposi's sarcoma (ks) primary lesions: an in situ hybridization study. | 1999 | 10232382 | |
| relationship of hhv8 replication and kaposi's sarcoma after solid organ transplantation. | hhv8 dna sequences have recently been isolated from all types of kaposi's sarcomas, and its association in the etiopathogenesis of this tumor has been established. however, little is known about the regulation of hhv8 replication in immunocompromised patients seropositive for this virus, and its impact on the development of kaposi's sarcoma (ks). through the study of a heart transplant patient who developed ks and in whom peripheral blood lymphocytes (pbls) had been prospectively collected befor ... | 1999 | 10232577 |
| kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality. | 1999 | 10233868 | |
| paclitaxel in the treatment of human immunodeficiency virus 1-associated kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study. | to describe the pharmacokinetics of paclitaxel and to investigate the interaction potential with protease inhibitors (indinavir, ritonavir, saquinavir) and the nonnucleoside reverse transcriptase inhibitor nevirapine, for which strong theoretical indications for clinically relevant drug interactions exist. | 1999 | 10321513 |
| kaposi's sarcoma-associated herpesvirus infection in the lung in multicentric castleman's disease. | a 32-year-old female was admitted for evaluation of multiple infiltrates on a chest radiograph. a diagnosis of multicentric castleman's disease was made on the basis of typical clinical manifestations. transbronchial lung biopsy (tblb) revealed histological findings reported in lymphocytic interstitial pneumonia. both the polymerase chain reaction and in situ hybridization with a probe specific for kaposi's sarcoma-associated herpesvirus (kshv) sequences demonstrated the presence of kshv in the ... | 1999 | 10337942 |
| human herpes virus-8 and other risk factors for kaposi's sarcoma in kidney transplant recipients. groupe cooperatif de transplantation d' ile de france (gcif). | the exact reasons for the high incidence of kaposi's sarcoma (ks) after kidney transplantation are still unknown. immunosuppression is classically considered as the main risk factor, but the relative risk contributed by the patient's geographic origin and by human herpes virus (hhv)-8 infection still has to be determined. | 1999 | 10342315 |
| the role of kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in lymphoproliferative diseases. | the kaposi's sarcoma-associated herpesvirus (kshv), also called human herpesvirus 8 (hhv-8), has been found to be present in a limited subset of lymphoproliferative disorders. among these are the primary effusion lymphomas, formerly designated body cavity-based lymphomas, a rare type of malignant lymphoma which possesses an unusual set of clinical and biologic features, suggesting that they represent a distinct disease entity. this virus is also present in a large proportion of cases of multicen ... | 1999 | 10343068 |
| the descent of human herpesvirus 8. | analysis of conserved herpesvirus genes shows that human herpesvirus 8 (hhv8) belongs to a clade of primate herpesviruses within the gamma2 sublineage. overall, this clade has developed by cospeciation with host species. seventeen genes of hhv8 and its nearest relatives lack simple homologues in other herpesviruses, and eight of these have known mammalian homologues, presumed to be the sources of the hhv8 versions. comparative analyses yield further insights into the source or time of acquisitio ... | 1999 | 10343071 |
| viral encoded cyclins. | cyclins are known effectors of cellular proliferation. while originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. one of these viruses is hhv-8, a gamma herpesvirus implicated as a causative agent of kaposi's sarcoma and lymphomas in humans. the significance of the virally encoded cyclin proteins in viral propagation is as yet unclear. however, the fact that deregulation of cellular cyclin expres ... | 1999 | 10343073 |
| reactivation and persistence of human herpesvirus-8 infection in b cells and monocytes by th-1 cytokines increased in kaposi's sarcoma. | patients with kaposi's sarcoma (ks) have a human herpesvirus-8 (hhv-8) load higher than patients without ks and present a cd8(+) t-cell activation with production of th1-type cytokines both in tissues and peripheral blood mononuclear cells (pbmc). because in tissues of ks patients detection of inflammatory cytokines (ic) can precede detection of hhv-8 dna and because signs of immunoactivation and/or dysregulation can precede ks development, we investigated the effect of ic on hhv-8 infection. to ... | 1999 | 10361101 |
| identification of the immediate-early transcripts of kaposi's sarcoma-associated herpesvirus. | in the immediate-early phase of reactivation or primary infection, herpesviruses express a small number of genes without requiring prior viral protein synthesis. immediate-early genes usually encode regulatory proteins critical for the viral life cycle. kaposi's sarcoma-associated herpesvirus (kshv) gene transcription in the immediate-early stage of viral reactivation was examined by using a chemical induction combined with a gene expression screening method. rna transcripts from at least four k ... | 1999 | 10364304 |
| identification and rapid quantification of early- and late-lytic human herpesvirus 8 infection in single cells by flow cytometric analysis: characterization of antiherpesvirus agents. | human herpesvirus 8 (hhv-8) infection is associated with kaposi's sarcoma, primary effusion lymphoma (pel), and multicentric castleman's disease. in this study, we used monoclonal antibodies (mabs) directed against hhv-8 lytic cycle-associated proteins encoded by open reading frame (orf) 59 (nuclear pf-8 protein) and orf k8.1 (viral envelope glycoprotein k8.1 [gpk8.1]) to investigate hhv-8 lytic infection in single cells. lytically infected cells were labeled with mabs, stained with fluorescentl ... | 1999 | 10364341 |
| [factors associated with survival in kaposi's sarcoma in patients infected with the human immunodeficiency virus. clinical epidemiological group for aids in aquitaine]. | to study behavioral risk factors of kaposi's sarcoma (ks) among hiv infected homosexuals in bordeaux, southwest france. | 1999 | 10367298 |
| an unusual cluster of cases of castleman's disease during highly active antiretroviral therapy for aids. | 1999 | 10375310 | |
| the human herpesvirus-type 8 is not involved in malignant melanoma. | malignant melanomas were supposed to harbour the human herpesvirus-type 8 (hhv-8) genome, as melanoma cells were reported to express interleukin-6 and a homologue of interleukin-6 was found in the hhv-8 genome. we therefore investigated 33 primary malignant melanomas by polymerase chain reaction, but could not find this tumorigenic gamma-herpesvirus in any tumour. | 1999 | 10389979 |
| cancer (or lack thereof) and viruses. | 1999 | 10390633 | |
| dominant human herpesvirus type 8 rna transcripts in classical and aids-related kaposi's sarcoma. | skin biopsy sections of kaposi's sarcoma (ks) from 25 patients (5 aids-related, 20 classical cases) were histologically staged and hybridized in situ with oligonucleotide probes for constitutively transcribed human herpesvirus 8 (hhv-8) mrna t0.7 and t1.1 using a colourimetric technique. t1.1 increases during experimental induction of the viral lytic phase in the hhv-8-infected lymphocytes of primary effusion lymphoma and its colourimetric detection in ks cells presumably corresponds to virion p ... | 1999 | 10398125 |
| absence of a link between human herpesvirus 8 and pemphigus. | 1999 | 10417537 | |
| establishing and characterizing a cd30-positive cell line harboring hhv-8 from a primary effusion lymphoma. | primary effusion lymphoma (pel, or body-cavity-based lymphoma [bcbl]) is a new subtype of non-hodgkin's lymphoma in which tumor cells locate in the body cavity exclusively. pel/bcbl is widely accepted as one of the neoplastic complications of aids, associated mostly with human herpesvirus 8 (hhv-8/kaposi's sarcoma-associated herpesvirus [kshv]) and epstein-barr virus (ebv). we established and characterized a pel cell line named ty-1 from a 47-year-old patient with aids. ty-1 exhibits indetermina ... | 1999 | 10421407 |
| overview of the epidemiology of malignancy in immune deficiency. | immune-suppressed populations experience higher rates of cancer than expected. the most common malignancies are non-hodgkin's lymphoma (nhl) in those with hiv infection, in organ transplant recipients, and in those with primary immune deficiencies; kaposi's sarcoma (ks) in those with hiv infection; and nonmelanoma skin cancer (sc) in transplant patients. these cancers are associated with infection with the epstein-barr virus (ebv) in nhl, human herpesvirus type 8 (hhv-8) in ks, and the human pap ... | 1999 | 10430211 |
| oncological complications of human immunodeficiency virus disease and hematologic consequences of their treatment. | despite advances in antiretroviral therapy and in the treatment and prevention of opportunistic infections, oncological and consequent hematologic complications of human immunodeficiency virus (hiv) infection continue to occur and are of significant clinical importance. virus-related tumors (e.g., kaposi's sarcoma, induced by human herpesvirus 8; non-hodgkin's lymphoma, linked to epstein-barr virus; and anogenital tumors, linked to human papillomavirus) are frequent in patients with hiv-induced ... | 1999 | 10433562 |
| [human herpes virus 8 and kaposi's sarcoma]. | 1999 | 10436595 | |
| functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. | human herpesvirus 8/kaposi sarcoma-associated virus (hhv-8/kshv) contains, in addition to genes required for viral replication, a unique set of nonstructural genes which may be part of viral mimicry and contribute to viral replication and pathogenesis in vivo. among these, hhv-8 encodes four open reading frames (orfs) that showed homology to the transcription factors of the interferon regulatory factor (irf) family. the orf k9, viral irf 1 (virf-1), has been cloned, and it was shown that, when o ... | 1999 | 10438822 |
| inflammatory cytokines synergize with the hiv-1 tat protein to promote angiogenesis and kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. | the tat protein of hiv-1, a transactivator of viral gene expression, is released by acutely infected t cells and, in this form, exerts angiogenic activities. these have linked the protein to the pathogenesis of kaposi's sarcoma (ks), a vascular tumor frequent and aggressive in hiv-1-infected individuals (aids-ks). in this study, we show that a combination of the same inflammatory cytokines increased in ks lesions, namely il-1 beta, tnf-alpha, and ifn-gamma, synergizes with tat to promote in nude ... | 1999 | 10438928 |
| unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection. | murine gamma-herpesvirus 68 (gammahv68) infection is a new model for understanding how immunity and chronic gamma-herpesvirus infection inter-relate. gammahv68 is closely related to the human epstein-barr virus and kaposi's sarcoma herpesvirus and is associated with tumors, vasculitis of the great elastic arteries and splenic fibrosis. advances in the past year have provided an even stronger foundation for believing that gammahv68 infection of normal and mutant mice will become the pre-eminent a ... | 1999 | 10448140 |
| hhv-8 infection and multiple myeloma. | human herpes virus 8 (hhv-8) also known as kaposi's sarcoma-associated herpes virus has been strongly implicated in the pathogenesis of kaposi's sarcoma (ks), primary effusion lymphoma, and multicentric castleman disease. recently, this gamma-herpes virus was also found in the nonmalignant bone marrow dendritic cells of the majority of myeloma patients. in addition, hhv-8 is also detectable in the peripheral blood of most myeloma patients. in contrast, this virus is rarely detected in close cont ... | 1999 | 10449181 |
| transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor. | human herpesvirus-8 (hhv-8), a gammaherpesvirus that is thought to be the viral aetiologic agent of kaposi's sarcoma and primary effusion lymphoma, encodes a homologue to cellular interferon regulatory factors (irfs). the hhv-8 irf homologue (virf; orf k9) has previously been shown to inhibit gene induction by interferons and irf-1 and to transform nih3t3 cells or rat-1 cells. additionally, expression of antisense to virf in bcbl-1 cells results in the repression of certain hhv-8 genes, suggesti ... | 1999 | 10466820 |
| human herpes virus 8 (hhv8) serology in allogeneic bone marrow transplant recipients. | human herpes virus 8 (hhv8) may be sexually transmitted, but transmission via blood cells has not yet been excluded. we used a modified immunofluorescence assay to detect ab to hhv8 latency-associated nuclear ag in sera of 200 allogeneic bmt recipients and their related donors. in control subjects, ab were found in 85% of patients with aids-related kaposi sarcoma (n = 52), 34% of hiv-1 infected subjects without kaposi sarcoma (n = 56) and 9. 5% of blood donors (n = 42). among bmt donors, 14.5% w ... | 1999 | 10467321 |
| absence of human herpes virus 8 in semen from healthy danish donors. | epidemiological data indicate a sexual route of transmission of acquired immune deficiency syndrome (aids) associated kaposi's sarcoma. recently human herpes virus 8 (hhv-8) has been proposed as the aetiological agent for development of kaposi's sarcoma. further the virus has been reported in semen obtained from healthy men. in denmark strict biochemical and microbiological criteria are used in combination with an intensive interview to select semen donors. despite these strict criteria, hhv-8 m ... | 1999 | 10469694 |
| human herpesvirus 8 and cancer. | 1999 | 10469737 | |
| expression of human herpesvirus-8 (hhv-8) encoded pathogenic genes in kaposi's sarcoma (ks) primary lesions. | transcription of six different hhv-8 specific mrnas was examined in early- and late-stage ks primary lesions. expression of the latency-associated t0.7 mrna and of vp23 mrna which is a specific marker of lytic/productive infection suggested that hhv-8 is secondarily recruited into the ks lesions by productively infected monocytes, macrophages. from these cells hhv-8 is transmitted to the ks spindle cells, which are latently infected. v-bcl-2, v-mcp-1 and v-il-6 were not expressed in latently inf ... | 1999 | 10470382 |
| absence of kaposi's sarcoma-associated herpesvirus dna in bacillary angiomatosis-peliosis lesions. | bartonella henselae and b. quintana induce an unusual vascular proliferative tissue response known as bacillary angiomatosis (ba) and bacillary peliosis (bp) in some human hosts. the mechanisms of bartonella-associated vascular proliferation remain unclear. although host factors probably play a role, microbial coinfection has not been ruled out. because of the vascular proliferative characteristics noted in both kaposi's sarcoma (ks) and ba and occasional colocalization of ks and ba, the possibi ... | 1999 | 10479179 |
| clinical and biological characteristics of human immunodeficiency virus-infected and uninfected intravascular drug users in ho chi minh city, vietnam. | to define the medical characteristics of intravascular drug users in ho chi minh city, vietnam, we examined 280 men, of whom 235 were infected with human immunodeficiency virus (hiv), being treated in a rehabilitation center. the patients used mainly opium, often in shooting galleries (50%). the prevalence of oral candidiasis (58%) and zoster infection (20%) was high in hiv-seropositive patients, whereas oral hairy leukoplasia and kaposi's sarcoma were absent. the prevalence of acquired immunode ... | 1999 | 10497983 |
| the inhibitor of death receptor signaling, flice-inhibitory protein defines a new class of tumor progression factors. | death receptor-mediated apoptosis can be modulated by several antiapoptotic proteins, such as the flice (fadd [fas-associated death domain]-like il-1beta-converting enzyme)-inhibitory proteins (flips). the flip family includes both cellular and viral members. the kaposi's sarcoma-associated herpesvirus protein (kshv)-flip is expressed by human herpesvirus 8 (hhv-8), which is associated with malignancies such as kaposi's sarcoma and certain lymphomas. in this paper, we demonstrate that kshv-flip ... | 1999 | 10510092 |
| molecular polymorphism of kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. | molecular polymorphism was found in kaposi's sarcoma-associated herpesvirus (kshv) latent nuclear antigen (lna), mapped to the internal repeat domain of the encoding orf73 gene, and used to develop a novel genotyping technique, kshv lna genotyping (kvnatyping). kvnatype was stable during latent and lytic viral replication in cell culture and in humans. diverse kvnatypes were identified in 43 specimens: 6 kshv cell lines and 6 kaposi's sarcoma (ks) and 4 primary effusion lymphoma (pel) tumor samp ... | 1999 | 10515805 |
| involvement of interleukin-10 (il-10) and viral il-6 in the spontaneous growth of kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. | primary effusion lymphoma (pel) is a distinct type of lymphoma associated with kaposi's sarcoma-associated herpesvirus (kshv) infection. to determine the factors responsible for the unrestrained proliferation of pel, we have studied the growth factor requirements of the pel-derived bcbl-1 and bc-1 cell lines. both cell lines were found to be autocrine growth factor dependent and to release human interleukin-6 (il-6), viral il-6 (vil-6), and human il-10 in the culture supernatant. to establish wh ... | 1999 | 10515891 |
| modulation of the nf-kappa b pathway by virally encoded death effector domains-containing proteins. | death effector domains (deds) have been known to mediate the recruitment of caspase 8 and its homologs to the aggregated death-inducing signaling complex (disc), consisting of the death domain (dd)-containing receptors and various signaling proteins. in addition, several viruses were recently shown to encode proteins with deds (also called flice inhibitory proteins or vflips) which have the ability of blocking cell death induced by dd-containing receptors. we provide evidence that vflips can als ... | 1999 | 10523854 |
| the spectrum of cutaneous lymphomas in hiv infection: a study of 21 cases. | we studied 21 hiv-associated lymphomas with cutaneous presentation to determine whether they showed features of primary cutaneous lymphoma arising fortuitously or whether they represented the cutaneous involvement of aids systemic lymphoma. besides rare mycosis fungoides (n = 3), which shared typical clinicopathologic lesions, nonepidermotropic large-cell lymphomas (n = 18) were predominant. they frequently presented as a solitary nodule or tumor. seven of the eight large t-cell lymphomas had a ... | 1999 | 10524521 |
| etiology of multiple myeloma: what's new. | both the tumor cells and the microenvironment of dendritic stromal cells appear to be involved in the etiology of multiple myeloma. switch translocations in myeloma tumor cells often involve oncogenes. these translocations have a clearly established role in the etiology of lymphoma and may prove to have a role in the transformation process of myeloma. dendritic stromal cells infected with human herpesvirus-8 may provide a growth and antiapoptosis advantage for myeloma bone marrow stromal cells v ... | 1999 | 10528889 |
| infection, immunity, and cancer. | a significant percentage of human cancers worldwide are associated with infections due to known viruses, including human papillomaviruses (cervical cancer and other skin cancers), human t-lymphotropic viruses (adult t-cell leukemias and lymphomas in endemic areas), hepatitis b virus (liver cancer), and epstein-barr virus (burkitt lymphoma and nasopharyngeal carcinoma). the fraction of human cancers attributable to infection may now need to be revised in light of the fact that new viral associati ... | 1999 | 10539899 |
| kaposi's sarcoma-associated herpesvirus-encoded g protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2. | the kaposi's sarcoma-associated herpesvirus (kshv) (also known as human herpesvirus 8) has been implicated in the pathogenesis of kaposi's sarcoma and b cell primary effusion lymphomas. kshv encodes a g protein-coupled receptor (gpcr) that acts as an oncogene and constitutively activates two protein kinases, c-jun amino-terminal kinase (jnk)/stress-activated protein kinase (sapk) and p38 mitogen-activated protein kinase. it also induces the production of vascular endothelial growth factor. these ... | 1999 | 10542211 |
| gene expression from the orf50/k8 region of kaposi's sarcoma-associated herpesvirus. | the orf50 gene of kaposi's sarcoma (ks)-associated herpesvirus, or human herpesvirus 8 (kshv), activates viral replication and is weakly homologous to the herpesvirus family of r transactivators; therefore, the transcription and translation events from this region of kshv are key events in viral reactivation. we demonstrate that orf50 is expressed in a bicistronic message after induction of the viral lytic cycle. orf50 migrated as a series of polypeptides: the major ones as 119 and 101 kda, resp ... | 1999 | 10544116 |
| [poems syndrome (polyneuropathy, organomegaly , endocrinopathy, monoclonal gammopathy, skin changes), multicentric castleman disease, renal chromophobe carcinoma and herpes virus type 8 infection]. | 1999 | 10544776 | |
| cytokines in the evolution and treatment of aids-lymphoma. | aids-lymphoma is a heterogeneous disease that most likely results from the complex interaction of several contributing factors, including chronic antigenic activation of b lymphocytes, dysregulated cytokine and co-stimulatory networks, infection with potentially oncogenic viruses (human herpesvirus-8 [hhv-8], epstein-barr virus), and accumulation of secondary genetic mutations. cytokines are believed to play an important role in the immunologic decline that favors opportunistic infection and mal ... | 1999 | 10550017 |
| motility induced by human immunodeficiency virus-1 tat on kaposi's sarcoma cells requires platelet-activating factor synthesis. | in the present study, we evaluated whether motility of kaposi's sarcoma (ks) spindle cells induced by hiv-1 tat protein is dependent on the synthesis of platelet-activating factor (paf). the results obtained indicate that tat induced a dose-dependent synthesis of paf from ks cells at a concentration as low as 0.1 ng/ml. paf production started rapidly after tat stimulation, peaking at 30 minutes and declining thereafter. tat-induced cell migration was also a rapid event starting at 30 minutes. th ... | 1999 | 10550329 |
| seroprevalence of human herpesvirus-8 (hhv-8) in countries of southeast asia compared to the usa, the caribbean and africa. | seroprevalence of hhv-8 has been studied in malaysia, india, sri lanka, thailand, trinidad, jamaica and the usa, in both healthy individuals and those infected with hiv. seroprevalence was found to be low in these countries in both the healthy and the hiv-infected populations. this correlates with the fact that hardly any aids-related kaposi's sarcoma has been reported in these countries. in contrast, the african countries of ghana, uganda and zambia showed high seroprevalences in both healthy a ... | 1999 | 10555764 |
| latent nuclear antigen of kaposi's sarcoma-associated herpesvirus interacts with ring3, a homolog of the drosophila female sterile homeotic (fsh) gene. | kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) is the likely infectious cause of kaposi's sarcoma, primary effusion lymphoma, and some cases of multicentric castleman's disease. its latent nuclear antigen (lana) is expressed in the nuclei of latently infected cells and may play a role in the persistence of episomal viral dna in dividing cells. here we report that lana interacts with ring3, a nuclear protein and member of the drosophila fsh (female sterile homeotic) family of proteins, some ... | 1999 | 10559289 |
| the latency-associated nuclear antigen tethers the kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. | viruses that establish latent infection must maintain their dna in the host nucleus through many cellular generations. here we identify a novel mechanism by which the gammaherpesvirus kaposi's sarcoma-associated herpesvirus (kshv) may achieve this persistence in latently infected body cavity-based lymphoma (bcbl) cells. we find that kshv genomic dna is associated with host chromosomes and colocalizes with the latency-associated nuclear antigen (lana). furthermore, a region at the left end of the ... | 1999 | 10562490 |
| no evidence for a role of human herpesvirus type 8 in sarcoidosis: molecular and serological analysis. | the aim of this study was to analyse the association between human herpesvirus type 8 (hhv8) and sarcoidosis. using nested polymerase chain reaction (pcr), we tested the presence of hhv8 dna sequences in 13 skin specimens and peripheral blood mononuclear cells from eight patients suffering from sarcoidosis. we also looked for the presence of hhv8 antibodies in the sera of 28 patients with sarcoidosis using three techniques: two indirect immunofluorescence assays and an enzyme-linked immunosorben ... | 1999 | 10583053 |
| human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant b lymphocytes. | human interleukin-6 (hil-6) acts as a growth factor in several human b lymphoid cancers. as human herpesvirus-8 (hhv-8) encodes for a viral il-6 (vil-6), the viral cytokine may be responsible for several manifestations of hhv-8-related disorders. using an anti-hil-6 mab (b-e8) which does not recognize vil-6, we investigated the involvement of the human cytokine in the proliferation of hhv-8-positive primary effusion lymphoma (pel) cells. in vitro, 5/5 pel cell lines produced hil-6 (4 to 1,200 pg ... | 1999 | 10586116 |
| [the genomic sequences of the human herpesvirus 8 in biological samples from hiv-positive and -negative subjects in sicily]. | 1999 | 10596444 | |
| experimental transmission of kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) to scid-hu thy/liv mice. | kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) is a novel human lymphotropic herpesvirus linked to several human neoplasms. to date, no animal model for infection by this virus has been described. we have examined the susceptibility of c.b-17 scid/scid mice implanted with human fetal thymus and liver grafts (scid-hu thy/liv mice) to kshv infection. kshv virions were inoculated directly into the implants, and viral dna and mrna production was assayed using real-time quantitative polymerase ... | 1999 | 10601360 |
| structure and function of the cc chemokine receptor (ccr) 8. | the cc chemokine receptor (ccr) 8 belongs to the seven transmembrane-spanning receptor family and functionally responds to the eukaryotic cc chemokines i-309, thymus and activation-regulated chemokine, macrophage inflammatory protein-1 beta (mip-1b) and to the products viral mip-i and viral mip-ii of the kaposi-associated herpesvirus (hhv-8). although it has not yet been fully characterised, its restricted expression to lymphoid tissues, i.e. thymus, spleen and lymph nodes, and its abundant up-r ... | 1999 | 10611408 |
| inflammatory cytokines and the reactivation of kaposi's sarcoma-associated herpesvirus lytic replication. | kaposi's sarcoma (ks) is a complex proliferative lesion long suspected of being dependent on exogenous paracrine signaling molecules to stimulate its proliferative, angiogenic, and inflammatory components. in particular, both clinical and experimental observations have pointed to a potential role for inflammatory cytokines as permissive factors for ks development, but ks pathogenesis is also critically dependent on infection by an exogenous herpesvirus, the ks-associated herpesvirus (kshv). to e ... | 2000 | 10612656 |
| kaposi sarcoma of major salivary gland origin: a clinicopathologic series of six cases. | kaposi sarcoma (ks), one of the defining tumors of acquired immune deficiency syndrome (aids), is rarely identified in the major salivary glands. to the authors' knowledge, no previous published series has evaluated the clinicopathologic aspects of this tumor in major salivary glands. | 2000 | 10618601 |
| human immunodeficiency virus-seropositive individual with persistent human herpesvirus 8 infection for >11 years without development of kaposi's sarcoma. | 2000 | 10619767 | |
| p53 inhibition by the lana protein of kshv protects against cell death. | kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8, has been implicated in the development of kaposi's sarcoma (ks) and several b-cell lymphoproliferative diseases. most cells in lesions derived from these malignancies are latently infected, and different viral gene products have been identified in association with lytic or latent infection by kshv. the latency-associated nuclear antigen (lana), encoded by open reading frame 73 of the kshv genome, is a highly immunogenic prot ... | 1999 | 10622254 |
| gammaherpesviruses and "hit-and-run" oncogenesis. | 2000 | 10623645 | |
| the human herpesvirus 8 homolog of epstein-barr virus sm protein (ks-sm) is a posttranscriptional activator of gene expression. | homologs of the epstein-barr virus (ebv) sm protein exist in several human and nonhuman herpesviruses. structure and function differ significantly among these proteins. we have cloned and characterized the human herpesvirus 8 (hhv8) gene, ks-sm, which is homologous to the ebv sm and herpes simplex virus icp27 genes, from an hhv8-infected primary effusion lymphoma. ks-sm is shown to be a posttranscriptional activator of gene expression in cotransfection studies. ks-sm activated gene expression in ... | 2000 | 10623771 |
| the role of human herpesvirus-8 in the pathogenesis of multiple myeloma. | human herpesvirus-8 has been strongly implicated in the pathogenesis of ks, bcbl, and multicentric castleman's disease. evidence for its role in the pathogenesis of multiple myeloma is accumulating. human herpesvirus-8 is detectable in the nonmalignant bone marrow dendritic cells from most myeloma patients. in addition, hhv-8 is also detected in the peripheral blood of most myeloma patients. in contrast, this virus is rarely detected in close contacts of myeloma patients, healthy individuals, or ... | 1999 | 10626142 |
| two distinct gamma-2 herpesviruses in african green monkeys: a second gamma-2 herpesvirus lineage among old world primates? | primate gamma-2 herpesviruses (rhadinoviruses) have so far been found in humans (kaposi's sarcoma-associated herpesvirus [kshv], also called human herpesvirus 8), macaques (macaca spp.) (rhesus rhadinovirus [rrv] and retroperitoneal fibromatosis herpesvirus [rfhv]), squirrel monkeys (saimiri sciureus) (herpesvirus saimiri), and spider monkeys (ateles spp.) (herpesvirus ateles). using serological screening and degenerate consensus primer pcr for the viral dna polymerase gene, we have detected seq ... | 2000 | 10627572 |
| kaposi's sarcoma following malignant mesothelioma. | we report the unusual occurrence of kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (hiv)-negative italian man. seropositivity to human herpes virus 8 (hhv8) was documented at the time of mesothelioma diagnosis and preceded the onset of kaposi' sarcoma with a time lapse of 13 months. hhv8 dna was detected by polymerase chain reaction in lesional kaposi's sarcoma but not within mesothelioma. by immunostaining, mesothelioma cells expressed interleuki ... | 1999 | 10628804 |
| aids-related body cavity-based lymphomas, herpesvirus-8 and hiv infection: a study of seven cases. | 1999 | 10630536 | |
| c-src mediates mitogenic signals and associates with cytoskeletal proteins upon vascular endothelial growth factor stimulation in kaposi's sarcoma cells. | vascular endothelial growth factor (vegf) appears to be a critical cytokine modulating the growth and spread of kaposi's sarcoma (ks). furthermore, infection with the ks herpes virus results in up-regulation of vegf and triggering of vegf receptor activation. the molecular mechanisms regulating such cytokine-driven proliferation of ks cells are not well characterized. we investigated the role of src-related tyrosine kinases in vegf-mediated signaling in model ks 38 tumor cells. vegf stimulation ... | 2000 | 10640727 |
| the role of human herpesvirus 8 in the pathogenesis of kaposi's sarcoma. | human herpesvirus 8 is a novel gamma-herpesvirus that has been linked with all clinical types of ks through both dna and serologic studies. by electron microscopic, in situ hybridization, and in situ pcr studies, virus is found in tumor spindle cells, in normal-appearing endothelial cells within lesions, and in tumor-infiltrating leukocytes. the fact that most tumor cells are latently, as opposed to lytically, infected with hhv8 makes the possibility of treating ks patients with antiherpesviral ... | 1999 | 10643499 |
| cyclin d1 expression and hhv8 in kaposi sarcoma. | human herpesvirus 8 (hhv8) appears to be the agent responsible for kaposi sarcoma. the mechanism remains undetermined but may involve cell cycle regulating genes including d type cyclins which are pivotal in cell cycle progression. recent hhv8 genetic analysis has revealed the presence of a v-cyclin which is homologous to d type cyclins. | 1999 | 10645225 |
| classic kaposi sarcoma: epidemiology and risk factors. | although kaposi sarcoma (ks) initially was described over a century ago, its biology remains enigmatic and conflicting. whereas the classic type occurs mainly in older men of mediterranean or eastern european backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immunodeficiency virus (hiv)-associated ks are linked to such conditions. a recently discovered pathogen, ks-associated herpesvirus (kshv) (also known as human herpesvirus 8 [hhv8]), is found in ti ... | 2000 | 10649240 |
| danish patients with untreated multiple myeloma do not harbour human herpesvirus 8. | the role of human herpesvirus 8 (hhv-8) in multiple myeloma (mm) remains controversial. we examined 15 danish mm patients before cytoreductive therapy. mononuclear cells isolated from peripheral blood and bone marrow aspirates, as well as long-term cultured bone marrow stromal cells, were assayed for the presence of hhv-8 dna. all material was tested by three simple unnested polymerase chain reaction (pcr) assays (amplifying regions of orf26, orfk1 and orf75) and two nested pcr assays (amplifyin ... | 2000 | 10651731 |
| human herpesvirus 8-associated solid lymphomas that occur in aids patients take anaplastic large cell morphology. | human herpesvirus type 8 (hhv-8; kaposi's sarcoma-associated herpesvirus) is a recently isolated human herpesvirus frequently identified in kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. here we report three cases of hhv-8-bearing solid lymphomas that occurred in aids patients (cases 1-3). all three patients were homosexual men presenting extranodal masses in the lungs (case 1) or skin (cases 2 and 3), together with the presence of kaposi's sarcoma (case 1), p ... | 2000 | 10658913 |
| differential expression of the hhv-8 vgcr cellular homolog gene in aids-associated and classic kaposi's sarcoma: potential role of hiv-1 tat. | human herpesvirus 8 (hhv-8) has been causally linked to kaposi's sarcoma (ks). there is significant homology between some hhv-8 genes and cellular genes including d-type cyclin (vcyc), g protein coupled receptor (vgcr), macrophage inflammatory proteins (vmip-i, vmip-ii), bcl-2 (vbcl2), interferon regulatory factor-1 (virf1), interleukin-6 (vil6), and complement-binding protein (vcbp). in this study, we analyzed expression of these viral homologs and hiv-1 tat by reverse-transcriptase polymerase ... | 2000 | 10662620 |
| risk factors for human herpesvirus 8 seropositivity and seroconversion in a cohort of homosexual men. | sexual and nonsexual modes of transmission of human herpesvirus 8 (hhv8) have been suggested, but specific routes remain unclear. therefore, the objective of this study was to assess risk factors for hhv8 seropositivity and determine specific sexual practices associated with hhv8 seroconversion. sera from 1,458 homosexual men (amsterdam cohort study, 1984-1996) were tested for antibodies to hhv8 with a modified version of an enzyme immunoassay, using recombinant hhv8 lytic phase capsid (orf65) a ... | 2000 | 10670545 |
| detection of antibodies to human herpesvirus 8 in italian children: evidence for horizontal transmission. | human herpesvirus 8 (hhv-8), also known as kaposi's sarcoma associated herpesvirus (kshv), has been shown to be the causative agent for kaposi's sarcoma (ks) and to be more prevalent in populations or risk groups at increased risk for ks. hhv-8 infection is rare in children from the us and the uk, but has been reported in african children. in this study we examine hhv-8 infection in children from italy, a country with an elevated prevalence of hhv-8 in adults and high socio-economic conditions. | 2000 | 10682685 |
| do intravenous immunoglobulin products manufactured from plasma collected in italy place immunocompromised patients at risk of contracting human herpesvirus 8? | 2000 | 10686015 | |
| occurrence of primary cancers in association with multiple myeloma and kaposi's sarcoma in the united states, 1973-1995. | the causes of multiple myeloma (mm) are obscure, but a laboratory association was recently reported between mm and human herpesvirus 8 (hhv-8), the probable etiologic agent of kaposi's sarcoma (ks). although there has been some additional laboratory corroboration, most laboratory studies have found no association between mm and hhv-8. we looked for indirect evidence of an hhv-8/mm association by evaluating whether mm is associated with ks in the united states. cancer incidence and survival data ... | 2000 | 10699913 |
| the primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. | the primary sequence of the long unique region l-dna (l for low gc) of rhesus monkey rhadinovirus (rrv) isolate 26-95 was determined. the l-dna consists of 130,733 bp that contain 84 open reading frames (orfs). the overall organization of the rrv26-95 genome was found to be very similar to that of human kaposi sarcoma-associated herpesvirus (kshv). blast search analysis revealed that in almost all cases rrv26-95 coding sequences have a greater degree of similarity to corresponding kshv sequences ... | 2000 | 10708456 |
| changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy. | the purpose of this study was to determine temporal trends in the prevalence of oral manifestations of human immunodeficiency virus (hiv). | 2000 | 10710453 |
| serologic prevalence of antibody to human herpesvirus type 8 in patients with various monoclonal gammopathies. | both viral and serologic studies have consistently shown an association of human herpesvirus type 8 (hhv-8) with kaposi's sarcoma, primary effusion lymphoma, and castleman's disease. the presence of hhv-8 dna in patients with myeloma has been reported by some investigators but not substantiated by others. in addition, variable results have been obtained with serologic studies for hhv-8 in patients with myeloma and certain other monoclonal gammopathies (mg). we tested 238 coded serum or plasma sa ... | 2000 | 10721787 |
| kaposi's sarcoma of the pancreas mimicking pancreatic cancer in an hiv-infected patient. clinical diagnosis by detection of hhv 8 in bile and complete remission following antiviral and cytostatic therapy with paclitaxel. | diagnosis of pancreatic cancer is usually made by endoscopic retrograde cholangiopancreatography (ercp) and corresponding findings in computed tomography (ct) or magnetic resonance imaging. kaposi's sarcoma, a frequent tumor in individuals with a late-stage hiv infection, can be located in the gastrointestinal tract and cause identical symptoms to carcinoma of the same site. a close correlation of this tumor to human herpes virus 8 (hhv 8) has been known for several years and there are reports o ... | 1999 | 10732297 |
| detection of human herpesvirus 8 dna and antibodies to latent nuclear and lytic-phase antigens in serial samples from aids patients with kaposi's sarcoma. | human herpesvirus 8 (hhv-8) have recently implicated in the etiology of kaposi's sarcoma (ks), but the pathophysiologic and immunologic interactions between hhv-8 and the human host are incompletely understood. | 2000 | 10738143 |
| characterization of signaling cascades triggered by human interleukin-6 versus kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6. | kaposi's sarcoma-associated herpes virus (kshv) is associated with kaposi's sarcoma, multicentric castleman's disease, and body cavity-based lymphomas, settings in which human interleukin-6 (hil-6) acts as a growth factor. the kshv open reading frame k2 encodes for viral il-6 (vil-6), a protein with 25% amino acid identity to hil-6, which can promote the growth of hil-6-dependent cell lines. in the present study, we characterized biological sequelae and signaling cascades triggered by hil-6 vers ... | 2000 | 10741750 |
| lack of detection of human herpesvirus (hhv)-8 dna in lesional skin of german pemphigus vulgaris and pemphigus foliaceus patients. | 2000 | 10745034 | |
| quantitative analysis of human herpesvirus 8 viral load using a real-time pcr assay. | we have developed a quantitative real-time pcr (taqman) assay aimed at measuring the cellular human herpesvirus 8 (hhv-8) dna load in various clinical samples. standard curves were obtained by serial dilutions of a control plasmid containing both hhv-8 (orf73 gene) and the cellular target (human albumin gene). the assay appeared to be very sensitive (100% detection rate for at least 10 copies per well) and specific and was easily reproducible (less than 3% intra-assay variability, 5% interassay ... | 2000 | 10747115 |
| hhv-8 (kshv) is not associated with bacillary angiomatosis. | bacillary angiomatosis is a rare pseudoneoplastic angioproliferative lesion occurring in patients with aids. this condition has been associated with bartonella henselae and bartonella quintana infections. human herpesvirus 8 (hhv-8) is thought to be the causative agent of kaposi's sarcoma, a vasoproliferative neoplasm, also commonly found in patients with aids. the presence of hhv-8 in a cohort of patients with bacillary angiomatosis was investigated. | 1999 | 10748868 |
| dermatologic manifestations among human immunodeficiency virus patients in south india. | human immunodeficiency virus (hiv) may be associated with a large number of dermatologic manifestations, which may at times constitute the presenting symptoms. these skin lesions are well delineated in the western literature, but there is a paucity of information from the southern part of the indian subcontinent. objective we evaluated 833 persons with hiv to determine the types of dermatologic lesions present. | 2000 | 10759958 |
| prevalence of hhv-8 infection among cancer patients in sicily. | 2000 | 10760837 | |
| conjugal hhv-8 infection with cutaneous kaposi's sarcomas and castleman's disease: fortuitous association or not? | 2000 | 10773709 | |
| il-6 receptor independent stimulation of human gp130 by viral il-6. | the genome of human herpes virus 8, which is associated with kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of il-6. although the function of these viral proteins is unclear, they might have the potential to modulate the immune system. for viral il-6 (vil-6), it has been demonstrated that it stimulates il-6-dependent cells, indicating that the il-6r system is used. il-6 binds to il-6r, and the il-6/il-6r complex associates with gp130 which ... | 2000 | 10779772 |
| early peripheral lymph node involvement of human herpesvirus 8-associated, body cavity-based lymphoma in a human immunodeficiency virus-negative patient. | human herpesvirus 8 (hhv-8), or kaposi sarcoma-associated herpesvirus, is a gamma herpesvirus first detected in a specimen of kaposi sarcoma from a human immunodeficiency virus (hiv)-positive patient. human herpesvirus 8 is also found in an unusual clinicopathologic form of body cavity-based b-cell lymphoma, which has been named primary effusion lymphoma (pel) and occurs primarily in hiv-positive patients. pel is characterized by the formation of lymphomatous effusions, without obvious lymphaden ... | 2000 | 10782162 |
| immunohistochemical detection of bcl-2 in kaposi's sarcoma lesions varies according to histopathologic stage, whereas expression of bcl-x and mcl-1 differs according to human immunodeficiency virus serologic status of patients. | expression of bcl-2, bcl-x, and mcl-1 was immunohistochemically evaluated in 33 cases of kaposi's sarcoma (ks) of the skin. of these, classic ks (c-ks) accounted for 17 cases (10 in plaque stage and 7 in tumor stage) and acquired immunodeficiency syndrome-associated ks (aids-ks) accounted for 16 cases (8 in plaque stage and 8 in tumor stage). in both c-ks and aids-ks, bcl-2 immunoreaction correlated with progression stage, its average score intensity being more than 2-fold in tumors than in plaq ... | 2000 | 10786812 |
| yuan chang and patrick moore. sharing an office and a marriage, they hunt infectious agents. | 2000 | 10788167 | |
| addressing controversies over kaposi's sarcoma. | 2000 | 10793096 | |
| human kaposi's sarcoma cell-mediated tumorigenesis in human immunodeficiency type 1 tat-expressing transgenic mice. | the human immunodeficiency virus type 1 (hiv-1) transactivator (tat) protein has been linked to the development and course of kaposi's sarcoma (ks) associated with acquired immunodeficiency disease syndrome (aids-ks). tat is an 86-101 amino-acid protein encoded by two exons. to evaluate the growth-promoting effects of tat in aids-ks in vivo, we developed transgenic mice expressing the one-exon-encoded 72 amino-acid protein (tat(72)) and the two-exon-encoded 86 amino-acid protein (tat(86)). | 2000 | 10793108 |
| infectious and neoplastic disorders of the thyroid in aids patients: an autopsy study. | the course of human immunodeficiency virus infection and the acquired immunodeficiency syndrome can be complicated by a variety of endocrine abnormalities. this article describes the findings of a prospective autopsy study of the thyroid in 100 patients who died of complications of aids before the advent of the so-called highly active antiretroviral therapy [corrected]. a wide range of bacterial, fungal, viral, and neoplastic disorders were observed. mycobacterium tuberculosis was recorded in 23 ... | 2000 | 10795071 |
| downregulation of major histocompatibility complex class i molecules by kaposi's sarcoma-associated herpesvirus k3 and k5 proteins. | the t-cell-mediated immune response plays a central role in the defense against intracellular pathogens. to avoid this immune response, viruses have evolved elaborate mechanisms that target and modulate many different aspects of the host's immune system. a target common to many of these viruses is the major histocompatibility complex (mhc) class i molecules. kaposi's sarcoma-associated herpesvirus (kshv) encodes k3 and k5 zinc finger membrane proteins which remove mhc class i molecules from the ... | 2000 | 10799607 |
| kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. | since the discovery of the virus in 1994, the rapid pace with which karposi's sarcoma-associated herpesvirus (kshv) research has progressed has quickly led to a broad understanding of the structure of the virus and its biology and pathology in humans. molecular piracy of potentially useful cellular genes has emerged as a characteristic feature of this virus. the viral homolog of human il-6, vil-6 is an example in kind. studies in vitro and in vivo have shown that vil-6 can stimulate the growth o ... | 2000 | 10813527 |
| viral cyclins. | cyclins are regulatory subunits of the cyclin-dependent protein kinases (cdks). members of this serine-threonine kinase family regulate the progression of cells through the division cycle. until some years ago, cyclins were presumed to be encoded exclusively by eukaryotic cells. however, sequencing in 1996 of a simian herpesvirus, the herpesvirus saimiri, uncovered an open reading frame with sequence similarity to cellular cyclins. what at the time was a surprise for virologists and cell biologi ... | 2000 | 10815028 |
| proceedings of the 3rd international conference on human herpesviruses 6, 7 and 8. clearwater beach, florida, usa. may 13-15, 1999. | 2000 | 10819584 | |
| hhv-8: a newly recognized pathogen in transplantation. | 2000 | 10830205 | |
| outcome of kidney transplant recipients with previous human herpesvirus-8 infection. | the consequences of a prior human herpesvirus-8 (hhv-8) infection in kidney-transplant recipients are still partially unknown. the aim of this monocentric study was to determine the prevalence of hhv-8-seropositive patients at the time of transplantation and to identify the main clinical events of these hhv-8+ recipients. | 2000 | 10830210 |
| increased expression of vascular endothelial growth factor (vegf) in castleman's disease: proposed pathomechanism of vascular proliferation in the affected lymph node. | castleman's disease is a lymphoproliferative disorder of unknown etiology characterized by enlarged hyperplastic lymph nodes with marked vascular proliferation. to evaluate the possible involvement of vascular endothelial growth factor (vegf) in the pathogenesis of castleman's disease, we studied vegf expression in sera and lymph nodes from four patients with either the plasma-cell type or mixed type of castleman's disease. clinically, one patient had the multicentric type and the others the loc ... | 2000 | 10830746 |