Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| review article: clinical significance of mucosal-protective agents: acid, inflammation, carcinogenesis and rebamipide. | while a great deal of clinical evidence has been found regarding anti-acids for the treatment of gastric disorders including peptic ulcers, not all disorders can be explained only by the hyperfunction of acid secretion. especially in the asian region, glandular atrophy is more prominent than in western countries, therefore low acid output is often observed in these patients. improvement of mucosal protection is rational therapy for these patients; this is the reason for use of these agents in as ... | 2003 | 12925154 |
| human leukocyte antigen class ii genes and helicobacter pylori infection: does genotype overwhelm environmental exposure? | we investigated associations between human leukocyte antigen class ii genes, environmental exposures, and helicobacter pylori infection. | 2003 | 12921878 |
| recent advances in helicobacter pylori infection in children: from the petri dish to the playground. | helicobacter pylori infection is acquired in childhood, plays a causative role in chronic gastritis and peptic ulcer disease, and is associated with the development of gastric cancer. the present review focuses on recent advances in the scientific knowledge of h pylori infection in children, including clinical sequelae, diagnosis and treatment. in addition, recent insights regarding both bacterial and host factors that mediate human diseases associated with h pylori infection are discussed. | 2003 | 12915920 |
| occurrence of a nontypable helicobacter pylori strain lacking lewis blood group o antigens and dd-heptoglycan: evidence for the role of the core alpha1,6-glucan chain in colonization. | the cell envelope of helicobacter pylori contains a lipopolysaccharide (lps) essential for the physical integrity and functioning of the bacterial cell membrane. the o-chain of this lps frequently expresses type 2 lewis x (lex) and lewis y (ley) blood group antigens that mimic human gastric mucosal cell-surface glycoconjugates. this article describes the isolation and structural analysis of the lps from a clinical isolate of h. pylori strain pj2 that lacks le antigens but is still capable of col ... | 2003 | 12907691 |
| idiopathic interstitial pneumonia following stem cell transplantation. | idiopathic interstitial pneumonia (iip) can occur after stem cell transplantation, but the aetiology is unknown. based on the association between angiitis syndrome and helicobacter pylori infection, we identified possible risk factors common to these two conditions. among 83 patients who underwent stem cell transplantation, four developed iip. we elucidated various parameters and clinical features in four patients with iip and 79 patients without, after allogeneic stem cell transplantation. in a ... | 2003 | 12868990 |
| topology and membrane interaction of helicobacter pylori comb proteins involved in natural transformation competence. | the human gastric pathogen helicobacter pylori is naturally competent for genetic transformation. the h. pylori comb gene duster encodes the virb4-homologous atpase comb4 and the structural proteins comb7-comb10, which share significant sequence identity to the agrobacterium tumefaciens virb-encoded type iv secretion system. to study the topology of the comb7-10 proteins, we applied tnmax transposon mutagenesis by generating fusions of comb proteins with mature beta-lactamase (blam) or alkaline ... | 2003 | 12868652 |
| [chronic urticaria and infectious diseases]. | infectious diseases are often considered as a classic cause of chronic urticaria. nevertheless, laboratory investigations greatly vary from one centre to the other and the link between the infection and skin signs does not rely on hard data. the purpose of this work was a systematic analysis of the published cases of urticaria associated with infection. | 2003 | 12843809 |
| association between infections and signs and symptoms of 'atopic' hypersensitivity--results of a cross-sectional survey among first-year university students in germany and spain. | this study assessed the hypothesis that a decreased exposure to childhood infectious diseases is associated with signs and symptoms of 'atopic' hypersensitivity diseases. | 2003 | 12823114 |
| gastric transitional zones, areas where helicobacter treatment fails: results of a treatment trial using the sydney strain mouse model. | current combination therapies cure helicobacter pylori infection in 75 to 85% of cases. however, many treatment failures are not explained by antibiotic resistance. our goal was to explore treatment failures under in vivo conditions by using the h. pylori sydney strain (ss1) mouse model. mice infected with h. pylori (ss1) were treated with monotherapies or combination therapies used in human trials. bacterial levels and distribution of organisms within the stomach were assessed 24 h after treatm ... | 2003 | 12821476 |
| time-dependent amplified pharmacokinetic and pharmacodynamic responses of rabeprazole in cytochrome p450 2c19 poor metabolizers. | to determine the pharmacokinetic and pharmacodynamic rationale for the optimum regimen of rabeprazole in the treatment of helicobacter pylori infection in patients who are cytochrome p450 (cyp) 2c19 poor metabolizers or extensive metabolizers. | 2003 | 12820812 |
| molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation. | atherosclerosis has long been recognised as having an inflammatory component, and this has a particularly important bearing on to its clinical complications as it may result in plaque instability. results of recent epidemiological studies have reinforced the potential importance of this aspect of the disease. positive associations have been reported between exposure to several specific pathogens, and future risk of coronary heart disease (chd). whilst it is possible that each individual organism ... | 2003 | 12818399 |
| animal models of helicobacter pylori infection and disease. | the acceptance of helicobacter pylori as a major human pathogen has necessitated the development of animal models to help elucidate the pathogenic mechanisms of this bacterium and aid in the development of improved strategies for the treatment of gastric disease. appropriate models, utilising a range of animal species, have been developed to examine factors such as the influence of host responses and bacterial factors in disease development and the success of new therapeutic regimens, including ... | 2003 | 12814775 |
| priming and expression of immune responses in the gastric mucosa. | this review deals with the induction and expression of immune responses in the human stomach following mucosal immunisation. as prerequisites for developing a helicobacter pylori vaccine, the role of gastric inflammation, in particular inflammation induced by h. pylori infection, as well as lymphocyte homing within the common mucosal immune system, and the importance of immunisation route are discussed. | 2003 | 12814774 |
| expression of cd3 epsilon subunit in gastric parietal cells: a possible role in signal transduction? | cd3 antigen, formerly thought to be specific for t lymphocytes, has been found on gastric parietal cells in animals and humans. the common anti-cd3 antibodies recognize the epsilon subunit, which has a role in signal transduction. the aim of this study was to immunostain stomach specimens from humans and different animal species for cd3 antigen to determine if cd3 antigen is conserved across species and if cd3 antigen expression is altered in humans by use of certain drugs or the presence of gas ... | 2003 | 12812314 |
| effect of total secondary carotenoids extracts from chlorococcum sp on helicobacter pylori-infected balb/c mice. | helicobacter pylori is a human pathogen associated with type b gastritis, peptic ulcer disease and gastric cancer. a high intake of carotenoids has been suggested to prevent development of gastric malignancies. microalgae chlorococcum sp. could accumulate secondary carotenoids under stress conditions. the aim of the present study was to investigate whether dietary cell extract of chlorococcum sp. could affect the bacterial load of h. pylori infected balb/c mice and whether it could induce modula ... | 2003 | 12810355 |
| trailing gastrointestinal pathogenesis. | 2003 | 12795744 | |
| increased zinc finger protein zfoc1 transcripts in gastric cancer compared with normal gastric tissue. | screening of cdna arrays of the image library identified human zfoc1 as a differentially expressed cdna that was upregulated in kato iii gastric cancer cells following stimulation with the gastric pathogen helicobacter pylori. | 2003 | 12782764 |
| disruption of the epithelial apical-junctional complex by helicobacter pylori caga. | helicobacter pylori translocates the protein caga into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. we show that injected caga associates with the epithelial tight-junction scaffolding protein zo-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex. long-term caga delivery to p ... | 2003 | 12775840 |
| helicobacter pylori activates toll-like receptor 4 expression in gastrointestinal epithelial cells. | helicobacter pylori activates the transcription factor nf-kappab, leading to proinflammatory cytokine production by gastric epithelial cells. however, the receptors for the initial bacterial interaction with host cells which activate downstream signaling events have not been completely defined. recently, it has been shown that microbial components activate toll-like receptors (tlrs), thereby leading to ap-1- and nf-kappab-dependent transcription and resulting in the production of proinflammatory ... | 2003 | 12761134 |
| helicobacter pylori infection affects the expression of pcna, p53, c-erbb-2 and bcl-2 in the human gastric mucosa. | helicobacter pylori infection has been related to gastric carcinogenesis. this association is based on epidemiological data, pathological changes observed in the gastric mucosa, and chemical products from bacteria that may induce damage of dna. in the present study we examined gastric endoscopic biopsies from patients with chronic gastritis, with and without h. pylori infection, and surgical biopsies from gastric cancer patients to evaluate whether this bacteria may induce changes in the express ... | 2003 | 12760717 |
| cell adhesion-related gene expression by helicobacter pylori in gastric epithelial ags cells. | helicobacter pylori (h. pylori) infection leads to gastroduodenal inflammation, peptic ulceration and gastric carcinoma. h. pylori may induce disease-specific gene expression in gastric epithelial cells. cdna microarray for 352 cancer-related genes was used to identify the genes altered by h. pylori (caga positive) in gastric epithelial ags cells. expressions of the genes identified on the microarray and other genes closely associated with these genes were determined by reverse transcriptase-pol ... | 2003 | 12757765 |
| strategies for the enrichment and identification of basic proteins in proteome projects. | two-dimensional gel electrophoresis (2-de) is currently the method of choice for separating complex mixtures of proteins for visual comparison in proteome analysis. this technology, however, is biased against certain classes of proteins including low abundance and hydrophobic proteins. proteins with extremely alkaline isoelectric points (pi) are often very poorly represented using 2-de technology, even when complex mixtures are separated using commercially available ph 6-11 or ph 7-10 immobilize ... | 2003 | 12748937 |
| t helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. | atherosclerotic lesions are infiltrated by macrophages and t lymphocytes, potentially reactive to pathogens. we studied in vivo activated t lymphocytes that infiltrate atherosclerotic plaques of helicobacter pylori-infected patients with or without anti-chlamydia pneumoniae antibodies. in all atherosclerotic lesions, t helper type 1 (th1) cells were predominant. c. pneumoniae-specific t cells were detected only in the plaques of anti-c. pneumoniae seropositive patients, whereas h. pylori-specifi ... | 2003 | 12740434 |
| long-term treatment with sterigmatocystin, a fungus toxin, enhances the development of intestinal metaplasia of gastric mucosa in helicobacter pylori-infected mongolian gerbils. | helicobacter pylori is a human gastric carcinogen. sterigmatocystin (st), a fungus toxin, is a risk factor of gastric cancer. cytotoxin-vacuolation toxin a (vaca) present in supernatants of h. pylori suspensions can cause gastritis and ulcer. the aim of this study was to examine the effects of h. pylori, st and vaca in mongolian gerbils. | 2003 | 12739707 |
| endotoxic and immunobiological activities of a chemically synthesized lipid a of helicobacter pylori strain 206-1. | a synthetic lipid a of helicobacter pylori strain 206-1 (compound hp206-1), which is similar to its natural lipid a, exhibited no or very low endotoxic activities as compared to escherichia coli-type synthetic lipid a (compound 506). furthermore, compound hp206-1 as well as its natural lipid a demonstrated no or very low mitogenic responses in murine spleen cell. on the other hand, compound hp206-1 showed a weaker but significant production of interleukin-8 in a gastric cancer cell line, mkn-1, ... | 2003 | 12727359 |
| cytotoxic and multidrug resistance reversal activity of a vegetable, 'anastasia red', a variety of sweet pepper. | the vegetable, anastasia red, capsicum annuum l. var. angulosum mill. (solanaceae) was successively extracted with hexane, acetone, methanol and 70% methanol, and the extracts were further separated into a total of 21 fractions by silica gel or octadecylsilane (ods) column chromatography. the biological activities of extracts and fractions were determined. these extracts showed relatively higher cytotoxic activity against two human oral tumor cell lines (hsc-2, hsg) than against normal human gin ... | 2003 | 12722138 |
| helicobacter pylori water soluble surface proteins prime human neutrophils for enhanced production of reactive oxygen species and stimulate chemokine production. | chronic gastritis induced by helicobacter pylori is characterised by considerable neutrophil infiltration into the gastric mucosa without mucosal invasion of bacteria. bacteria have different characteristics with respect to their ability to stimulate human neutrophils to produce reactive oxygen species and chemokines. the aim of this study was to examine the effects of h pylori water extracts on the oxidative burst and chemokine production of human neutrophils. | 2003 | 12719454 |
| limited role of lipopolysaccharide lewis antigens in adherence of helicobacter pylori to the human gastric epithelium. | in vitro and in vivo studies from various groups have suggested that helicobacter pylori lipopolysaccharide (lps) lewis x (le(x)) antigens mediate bacterial adhesion. we have now reevaluated this hypothesis by studying the adherence in situ of h. pylori strain 11637 and its corresponding le(x)-negative rfbm mutant to human gastric mucosa from patients (n = 22) with various gastric pathologies. significant binding of the parent strain was observed in only 8 out of 22 sections; in four out of eigh ... | 2003 | 12704161 |
| gastric stump lymphoma five years after distal gastrectomy. | we report the case of a 77-year-old man who developed low grade b cell non-hodgkin's lymphoma of the gastric stump 5 years after undergoing a distal gastrectomy for benign gastric ulcer. lymphoma occurring in the post-operative stomach would appear to be very rare, with only 14 previously recorded cases. the median period of lymphoma onset after ulcer surgery is about 20 years (range 9-43 years) and gastric remnants of lymphoma are generally diagnosed in low stage, when surgery is possible and m ... | 2003 | 12688360 |
| heat shock protein of mycoplasma salivarium and mycoplasma orale strains isolated from hiv-seropositive patients. | it has been suggested that infection by some mycoplasma species can act as possible cofactors in the acceleration of immunodeficiency in hiv-infected patients. the present study was designed to examine infections by oral mycoplasma species in hiv-seropositive (hiv(+)) patients. mycoplasma salivarium and mycoplasma orale were isolated from 59.5% and 16.7% of 42 hiv(+) patients, respectively. non-m. salivarium and non-m. orale species were isolated from 40.5% of saliva samples from the hiv(+) grou ... | 2002 | 12687728 |
| expression cloning of a periodontitis-associated apoptotic effector, cage homologue, in actinobacillus actinomycetemcomitans. | to study anti-bacterial immunity and to identify critical bacterial antigens associated with specific periodontal infection, we screened the genomic library of actinobacillus actinomycetemcomitans, a major gram(-) anaerobe causing human periodontitis, by expression cloning using disease-associated periodontal cd4(+)t cells derived from hupbl-engrafted nod/scid mice. here, we report one of the novel genes identified and designated, cage homologue (in short: cage) of a. actinomycetemcomitans, whic ... | 2003 | 12684047 |
| variable frequencies of t(11;18)(q21;q21) in malt lymphomas of different sites: significant association with caga strains of h pylori in gastric malt lymphoma. | t(11;18)(q21;q21) is a specific chromosomal translocation associated with mucosa-associated lymphoid tissue (malt) lymphoma. it fuses the amino terminal of the api2 gene to the carboxyl terminal of the malt1 gene and generates a chimeric fusion product. although the translocation is frequently detected in gastric and pulmonary malt lymphoma, its incidence in malt lymphomas from other sites is largely unknown. it also remains unknown whether the occurrence of the translocation is influenced by th ... | 2003 | 12676782 |
| influence of gastrin on the expression of cyclooxygenase-2, hepatocyte growth factor and apoptosis-related proteins in gastric epithelial cells. | several studies have shown a link between gastrin and gastric cancer, both in humans and animals, especially infected with helicobacter pylori (h. pylori). however, the exact role of hypergastrinemia in gastric carcinogenesis remains still undetermined. the aim of the present study was to evaluate the interaction between gastrin, cyclooxygenase-2 (cox-2), hepatocyte growth factor (hgf) and apoptosis-related proteins (bax, bcl-2, caspase-3, survivin) in cultured gastric epithelial cancer cells. | 2003 | 12674216 |
| the neutrophil-activating protein of helicobacter pylori (hp-nap) activates the mapk pathway in human neutrophils. | infection by helicobacter pylori causes an acute inflammatory response followed by a chronic infection of the human gastric mucosa characterized by the infiltration of neutrophils andmononuclear inflammatory cells. the neutrophil-activating protein of helicobacter pylori (hp-nap) is a virulence factor that activates neutrophils, monocytes, and mast cells. however, the mechanism by which hp-nap activates these cells is not fully understood. here, we show that hp-nap induces extracellular regulate ... | 2003 | 12672049 |
| lafutidine, a novel histamine h2-receptor antagonist, vs lansoprazole in combination with amoxicillin and clarithromycin for eradication of helicobacter pylori. | in contrast to the growing amount of data concerning proton pump inhibitor-based triple therapy for helicobacter pylori infection, it is still controversial whether proton pump inhibitor can be replaced by h2 receptor antagonist without compromising efficacy. lafutidine is a novel potent h2 receptor antagonist with gastroprotective activities such as enhancement of gastric mucosal blood flow. | 2003 | 12662378 |
| molecular cloning of p53 cdna of mongolian gerbil and establishment of yeast p53 functional assay system. | epidemiological studies have shown a correlation between helicobacter pylori infection and human gastric carcinogenesis. a mongolian gerbil model has demonstrated that h. pylori infection induced gastric carcinoma. however, the disadvantage of this animal model is a lack of information regarding the cellular genes involved in oncogenesis. mutation of the p53 gene is one of the most common steps in gastric carcinogenesis. in this study, we aimed to clone the p53 gene of the mongolian gerbil and d ... | 2003 | 12662374 |
| mutant p53 expression and apoptotic activity of helicobacter pylori positive and negative gastritis in correlation with the presence of intestinal metaplasia. | mutation of the p53 gene is detectable in most cases of gastric cancer, as it is the most common genetic alteration in human malignancies. it is also well documented that helicobacter pylori infection plays an important role in gastric carcinogenesis. there is still no clarification, however, concerning how genetic instability influences the homeostasis of gastric epithelium. we have studied the effect of h. pylori infection on apoptosis of the antral epithelium in the presence/absence of intest ... | 2003 | 12655259 |
| cloning, expression and purification of three chaperonin 60 homologues. | the chaperonin 60 (cpn60) proteins have, in addition to their well-known functions of protein folding and protection, a range of intercellular signalling activities. as part of a study to investigate the biological activity of the cpn60 proteins, particularly from pathogenic organisms, we have cloned and expressed three cpn60 proteins from homo sapiens, helicobacter pylori and chlamydia pneumoniae. the cpn60 proteins were purified to apparent homogeneity using a combination of nickel column affi ... | 2003 | 12651007 |
| catalase (kata) and kata-associated protein (kapa) are essential to persistent colonization in the helicobacter pylori ss1 mouse model. | helicobacter pylori infects the human gastric mucosa and elicits an aggressive inflammatory response. despite the severity of the inflammatory response, the bacterium is able to persist and cause a chronic infection. it is believed that antioxidant defence mechanisms enable this organism to persist. wild-type h. pylori strain ss1, and kata- and kapa-deficient mutants, were used to infect c57/bl6 mice to test this hypothesis. neither kata nor kapa was essential for the initial colonization of h. ... | 2003 | 12634335 |
| helicobacter pylori in indian hiv infected patients. | helicobacter pylori is a causative organism for chronic gastritis and associated with peptic ulcer disease. infection may be asymptomatic as well. human immuno-deficiency virus infection predisposes to a multitude of opportunistic infections, many of them resulting in gastrointestinal symptoms. we studied the prevalence of h pylori co-infection with hiv and its correlation with gastrointestinal symptoms in hiv infected patients. seventy-three consecutive hiv infected patients presenting to the m ... | 2002 | 12632975 |
| the impact of parietal cells on helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice. | helicobacter pylori infection of the human stomach is common and typically benign, although a subset of hosts develops severe pathology. infection occurs in an organ with distinct microenvironments characterized by pronounced differences in the composition of acid-producing parietal cells. in this study, we examine determinants of bacterial tropism to various gastric niches by using germ-free normal and transgenic mice with an engineered parietal cell ablation. mice were colonized for 8 weeks wi ... | 2003 | 12629225 |
| the rapid detection of low molecular mass proteins differentially expressed under biological stress for four helicobacter spp. using proteinchip technology. | helicobacter pylori is one of the most prevalent human pathogens in the world and is the aetiological agent of gastritis, peptic ulcer disease and gastric malignancies. in addition h. pylori and other novel members of the genus are capable of successfully colonising the bile-rich niche of the upper intestine and are associated with a diverse range of intestinal pathologies. surface-enhanced laser desorption/ionisation-time of flight mass spectrometry was used to analyse surface extracts from h. ... | 2003 | 12627380 |
| the dendritic cell-specific c-type lectin dc-sign is a receptor for schistosoma mansoni egg antigens and recognizes the glycan antigen lewis x. | schistosoma mansoni soluble egg antigens (seas) are crucially involved in modulating the host immune response to infection by s. mansoni. we report that human dendritic cells bind seas through the c-type lectin dendritic cell-specific icam-3-grabbing nonintegrin (dc-sign). monoclonal antibodies against the carbohydrate antigens lewisx (lex) and galnacbeta1-4(fucalpha1-3)glcnac (ldnf) inhibit binding of dc-sign to seas, suggesting that these glycan antigens may be critically involved in binding. ... | 2003 | 12626400 |
| [tailor-made medicine in helicobacter pylori eradication therapy]. | pharmacokinetic profiles of omeprazole and lansoprazole were well correlated with the cyp2c19 genotype. the heterozygous extensive metabolizer was slightly different from the homozygote, but there was no statistically significant difference. the cyp2c19 genotype dependence found for lansoprazole was not obvious compared with omeprazole. as for rabeprazole, the pharmacokinetic profile was independent of the cyp2c19 genotype. cyp2c19 genotyping can provide a new strategy to choose an optimal regim ... | 2003 | 12607330 |
| [the prospects of vaccination against h. pylori infection]. | h. pylori causes numerous gastroduodenal diseases including malignancies. although eradication of h. pylori using antibiotics is clinically performed, it is sometimes unsuccessful because of resistant bacteria and patient non-compliance with treatment. therefore prophylactic and therapeutic vaccination against h. pylori infection is necessary for clinical use but it is still under study. h. pylori is widely believed to be transmitted in childhood. if long and chronic h. pylori infection causes g ... | 2003 | 12607329 |
| [helicobacter pylori--introduction and review of research]. | the discovery of helicobacter pylori has revolutionized the pathophysiological and clinical approach to gastric and duodenal ulcer. since the first paper identifying h. pylori was published only 17 years ago, it has been found out that this bacterium causes probably the commonest human infection. numerous papers published so far have confirmed causal relationship between h. pylori infection and gastritis, duodenal ulcer, gastric ulcer and gastric cancer. if any recent achievement in the world of ... | 2002 | 12592806 |
| review article: nsaids, gastroprotection and cyclo-oxygenase-ii-selective inhibitors. | in patients at high risk of nsaid-associated serious upper gastrointestinal complications, gastroprotection with misoprostol or a proton pump inhibitor should be considered. only misoprostol, 800 micro g/day, has been shown to reduce serious upper gastrointestinal complications in a large clinical outcome trial. the benefit of helicobacter pylori eradication in reducing nsaid-associated gastrointestinal toxicity is controversial, and routine testing for and eradication of h. pylori in nsaid user ... | 2003 | 12562444 |
| helicobacter pylori induces apoptosis in barrett's-derived esophageal adenocarcinoma cells. | helicobacter pylori may protect against the development of dysplasia in barrett's epithelium of patients with gastroesophageal reflux disease. the aim of this study was to determine whether h. pylori preferentially induces apoptosis in barrett's-derived cancer cells compared to normal cells. a barrett's-derived adenocarcinoma cell line (oe33) was grown. h. pylori wild-type, isogenic vaca-, caga(-), and picb-/cage- mutant strains were grown on agar plates. intact or sonicated bacteria were used t ... | 2003 | 12559187 |
| microbial agents associated with waterborne diseases. | many classes of pathogens excreted in feces are able to initiate waterborne infections. there are bacterial pathogens, including enteric and aquatic bacteria, enteric viruses, and enteric protozoa, which are strongly resistant in the water environment and to most disinfectants. the infection dose of viral and protozoan agents is lower than bacteria, in the range of one to ten infectious units or oocysts. waterborne outbreaks of bacterial origin (particularly typhoid fever) in the developing coun ... | 2002 | 12546197 |
| impact of clarithromycin resistance and cyp2c19 genetic polymorphism on treatment efficacy of helicobacter pylori infection with lansoprazole- or rabeprazole-based triple therapy in japan. | helicobacter pylori treatment failure is thought to be due mainly to polymorphic cytochrome p450 2c19 (cpy2c19) genetic polymorphism, associated with proton pump inhibitor metabolism, and antimicrobial susceptibility. this report has ascertained which was more important, cpy2c19 polymorphism or antimicrobial susceptibility, when using 1-week lansoprazole-based or rabeprazole-based triple therapy in japan. | 2003 | 12544691 |
| gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. | the expression of hypoxia inducible factor (hif)-1alpha protein is tightly regulated by cellular oxygen status. namely, hif-1alpha protein is degraded rapidly in normoxic cells, whereas hypoxia stabilizes hif-1alpha to transactivate hypoxia-responsive genes. here we show that hif-1alpha protein is expressed aberrantly in gastric cancer cells under normoxia in a reactive oxygen species (ros)-dependent manner. the normoxic expression of hif-1alpha in concordance with its dna binding activity enhan ... | 2003 | 12538497 |
| multiple infections and subsequent cardiovascular events in the heart outcomes prevention evaluation (hope) study. | limited prospective epidemiological data are available on the relation between exposure to chlamydia pneumoniae, helicobacter pylori, cytomegalovirus (cmv), and hepatitis a virus (hav), individually or as a total pathogen score, and human cardiovascular (cv) disease. | 2003 | 12538424 |
| association of cyclooxygenase-2 expression with hp-caga infection in gastric cancer. | to observe the expression of cyclooxygenase-2 (cox-2) and to investigate the association between cox-2 expression and infection with cytotoxic-associated gene a (caga) positive strain helicobacter pylori (hp) in human gastric cancer, and subsequently to provide fresh ideas for the early prevention of gastric cancer. | 2003 | 12532440 |
| deregulation of shp-2 tyrosine phosphatase by the helicobacter pylori virulence factor caga. | helicobacter pylori (h. pylori) is estimated to infect about half of the world population. it causes gastric diseases ranging from gastritis to cancer and has been classified as a class i carcinogen by who. however, little is known about the molecular mechanisms by which h. pylori induces pathogenesis. caga is the product of the caga gene carried among virulent h. pylori strains and is associated with severe clinical outcomes, most notably gastric carcinoma. caga is injected from the attached h. ... | 2002 | 12528933 |
| decreased epithelial cytokine responses in the duodenal mucosa of helicobacter pylori-infected duodenal ulcer patients. | helicobacter pylori colonizes the human stomach and areas of gastric metaplasia in the duodenum, but only a minority of those that are infected develop symptoms, e.g., peptic ulcers. although most ulcers occur in the duodenum, almost all studies of mucosal immune responses against the infection have been limited to responses in the stomach. in the present study we evaluated whether there are differences in the levels of proinflammatory cytokines as well as immunoregulatory cytokines in the duode ... | 2003 | 12522049 |
| chemokine receptor 5 expression in gastric mucosa of helicobacter pylori-infected and noninfected children. | experimental data from human adults or animal models indicate that the helicobacter pylori-specific immune response is dominated by inflammatory t cells of the th1 type. to investigate whether a th1 immune response is established in early h. pylori infection, gastric biopsy samples from 70 children were subjected to immunohistochemical analysis. to this end, t cells, b cells, monocytes, neutrophils, and chemokine receptor 5 (ccr5)-expressing (ccr5(+)) cells, which are associated with th1 immune ... | 2003 | 12522035 |
| helicobacter pylori organisms induce expression of activation and apoptotic surface markers on human lymphocytes and ags cells: a cytofluorimetric evaluation. | human peripheral blood mononuclear cells (pbmcs) were treated with helicobacter pylori (hp) organisms alone or with hp-stimulated ags cells (a gastric adenocarcinoma cell line). hp organisms were able per se to increase the percentage of cd8 +/- cd95 +/- cells, while number of cd25+ cells and hla-dr molecule expression increased following pretreatment with hp-stimulated ags cells. a comparison was made with a test system in which pbmcs were stimulated with escherichia coli (ec) organisms and col ... | 2002 | 12510791 |
| [relationship between helicobacter pylori infection and expressions of tumor suppressor genes in gastric carcinoma and related lesions]. | helicobacter pylori (hp) are believed to be a carcinogen of gastric carcinoma. however, its mechanism was yet not clearly understood. p53, p21waf1, and p16 are main negative regulator genes of cell cycle. this study was designed to investigate the relationship between these 3 genes and hp infection. | 2002 | 12508544 |
| expression of lewis(b) blood group antigen in helicobacter pylori does not interfere with bacterial adhesion property. | the finding that some helicobacter pylori strains express lewis b (le(b)) blood group antigen casts a doubt on the role of le(b) of human gastric epithelium being a receptor for h. pylori. the aim of this study was to determine if expression of le(b) in h. pylori interferes with bacterial adhesion property. | 2003 | 12508365 |
| plural transformation-processes from spiral to coccoid helicobacter pylori and its viability. | helicobacter pylori (h. pylori), present in a half of the world's population, is a very successful pathogen. the infection by this bacterium causes several gastric diseases in human. h. pylori is morphologically divided into two types; a spiral and a coccoid form. both types are observed in human stomach. although the former is converted into the latter in vitro, the process of coccoid formation remains obscure. furthermore, whether coccoid forms possess viability arouses much controversy among ... | 2003 | 12504609 |
| celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. | current guidelines recommend that patients at risk for ulcer disease who require treatment for arthritis receive nonsteroidal antiinflammatory drugs (nsaids) that are selective for cyclooxygenase-2 or the combination of a nonselective nsaid with a proton-pump inhibitor. we assessed whether celecoxib would be similar to diclofenac plus omeprazole in reducing the risk of recurrent ulcer bleeding in patients at high risk for bleeding. | 2002 | 12501222 |
| topographic association of gastric epithelial expression of ki-67, bax, and bcl-2 with antralization in the gastric incisura, body, and fundus. | helicobacter pylori (h. pylon) infection seems to induce antralization (ie., gastric mucosal transformation from transitional or body type to antral type), which is strongly associated with gastric atrophy and intestinal metaplasia. the aim of this study was to determine the topographic associations of ki-67 (a protein expressed in proliferative cells), bax (a pro-apoptotic protein), and bcl-2 (an antiapoptotic protein) expression with antralization. | 2002 | 12492185 |
| human beta-defensin-2 induction in helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression. | the objective of this study was to understand more of the innate immune response to helicobacter pylori by determining the expression of human beta-defensin-2 (hbd-2) in various gastric mucosal tissues and mkn45 gastric cancer cells with or without h. pylori. semi-quantitative taqman rt-pcr and immunohistochemistry were carried out. the antimicrobial effects of a transfected hbd-2 gene against h. pylori were also evaluated. the results showed that hbd-2 was expressed in inflamed gastric mucosal ... | 2003 | 12488564 |
| transcriptional regulation by thiol compounds in helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells. | reactive oxygen species (ros) have been counted among the potential toxic factors involving helicobacter pylori (h. pylori)-induced gastric injury. transcription nuclear factor-kappab (nf-kappab) is activated by ros and regulates inflammatory gene expression. thiol compounds, such as glutathione and n-acetylcysteine, scavenge hydrogen peroxide and are reported to prevent oxidative damage in various cells. the present study aims to investigate whether thiol compounds could affect h. pylori-induce ... | 2002 | 12485925 |
| is intestinal metaplasia of the stomach reversible? | intestinal metaplasia (im) of the stomach is a risk factor in developing intestinal-type gastric cancer and hence the question of reversibility is vital. there is emerging epidemiological evidence that with long term follow up, im may be reversible although a combination of antioxidant agents and eradication of h pylori may be necessary to achieve this. the pathogenesis of im is currently being elucidated and it is likely that a combination of bacterial, host, and environmental factors will be s ... | 2003 | 12477745 |
| involvement of tnf-alpha changes in human cancer development, prevention and palliative care. | cancer development and ageing are complex sciences. from the study on the process of rodent carcinogenesis, we identified tumor necrosis factor-alpha (tnf-alpha) as an important mediator of cancer development. this paper presents three clinical examples of tnf-alpha up-regulation: by cord factors of mycobacterium tuberculosis, such as trehalose 6-monomycolate, as an activator of protein kinase c and by a cord factor like fraction of microsporum canis obtained in the air inside houses in thailand ... | 2002 | 12470903 |
| the vacuolating toxin of helicobacter pylori mimicks the cftr-mediated chloride conductance. | cystic fibrosis (cf) is caused by defects of the cf transmembrane conductance regulator (cftr), which acts both as an anion-selective channel and as a regulator of other proteins. the relative contribution of these two functions in cf disease is debated. the toxin vaca forms channels with properties similar to those of the cftr, and we report here that it can insert into the membrane of various cells originating from respiratory epithelia, generating a chloride conductance comparable to that pro ... | 2002 | 12459497 |
| helicobacter pylori caga protein activates serum response element-driven transcription independently of tyrosine phosphorylation. | infection with helicobacter pylori possessing the cag pathogenicity island (pai) is associated with severe gastritis and gastric cancer. caga protein, one of the products of cag pai, is translocated into epithelial cells, where cytoskeletal rearrangements occur as a result of caga tyrosine (tyr) phosphorylation. here we identify a new role for caga protein as an activator of host cell signaling. | 2002 | 12454853 |
| helicobacter pylori releases a factor(s) inhibiting cell cycle progression of human gastric cell lines by affecting cyclin e/cdk2 kinase activity and rb protein phosphorylation through enhanced p27(kip1) protein expression. | helicobacter pylori, the main cause of chronic gastritis, plays a central role in the etiology of peptic ulcer disease and gastric cancer. in vitro studies have shown that h. pylori increases gastric epithelial cell turnover, thus increasing the risk for the development of neoplastic clones. the mechanisms by which h. pylori promotes perturbation of cell proliferation are not yet elucidated. to investigate whether products released by h. pylori in culture media interfere with cell cycle progress ... | 2002 | 12441136 |
| comparative analysis of helicobacter dnas and biliary pathology in patients with and without hepatobiliary cancer. | several helicobacter species have recently been isolated from the bile and hepatobiliary systems of murine species, and are well recognized as a pathogen of the hepatobiliary disorder. this study was planned to investigate whether helicobacter species possess a causative potential for human hepatobiliary disease, especially for hepatobiliary carcinogenesis. bile and hepatobiliary tissue samples from 19 patients with hepatobiliary cancer and 19 patients with benign biliary diseases were subjected ... | 2002 | 12419842 |
| grb2 is a key mediator of helicobacter pylori caga protein activities. | caga delivered from helicobacter pylori into gastric epithelial cells undergoes tyrosine phosphorylation and induces host cell morphological changes. here we show that caga can interact with grb2 both in vitro and in vivo, which results in the activation of the ras/mek/erk pathway and leads to cell scattering as well as proliferation. importantly, this ability of caga is independent from the tyrosine phosphorylation, which occurs within the five repeated epiya sequences (py region) of caga. howe ... | 2002 | 12419219 |
| responses of endoscopy patients in ladakh, india, to helicobacter pylori whole-cell and cag a antigens. | although helicobacter pylori is a cosmopolitan colonizer of the human stomach, the responses among persons in remote populations from whom h. pylori was cultured have not been studied. we report on studies of 189 persons in the ladakh region of india in whom serum immunoglobulin g responses to h. pylori whole-cell and cag a antigens were measured. h. pylori was isolated from 68 of these patients. an h. pylori whole-cell antigen derived from ladakhi strains outperformed a similar antigen from u.s ... | 2002 | 12414766 |
| cag pathogenicity island-specific responses of gastric epithelial cells to helicobacter pylori infection. | helicobacter pylori infects over half the world's population and causes a wide range of diseases, including gastritis, peptic ulcer, and two forms of gastric cancer. h. pylori infection elicits a variety of phenotypic responses in cultured gastric epithelial cells, including the expression of proinflammatory genes and changes in the actin cytoskeleton. both of these responses are mediated by the type iv secretion system (tfss) encoded by the cag pathogenicity island (cag pai). we used human cdna ... | 2002 | 12411577 |
| [probiotics: history, definition, requirements and possible therapeutic applications]. | the ingestion of probiotics is associated with various beneficial effects on human health and modifies the physiological homeostasis of the intestinal flora. probiotics are microorganisms with some particular characteristics: human origin, safety in human use, bile and acid resistance, survival in the intestine, at least temporary colonization of the human gut, adhesion to the mucosa and bacteriocine production. thanks to these characteristics, probiotics block the invasion of human intestinal c ... | 2002 | 12402663 |
| effect of mannitol on helicobacter pylori-induced cyclooxygenase-2 expression in gastric epithelial ags cells. | oxygen radicals have been considered to be important regulatory molecules in helicobacter pylori-induced gastric ulceration and carcinogenesis. h. pylori-induced inflammation has been shown to be associated with cyclooxygenase-2 (cox-2) expression in experimental animals and human patients. this study aimed to determine if h. pylori produces oxygen radicals and induces cox-2 expression in gastric epithelial cells. a further aim was to resolve whether or not the h. pylori-induced cox-2 expression ... | 2002 | 12393940 |
| relationship between gastric ulcer and helicobacter pylori vaca detected in gastric juice using bead-elisa method. | vaca is an important pathogenetic factor produced by helicobacter pylori. vaca has often been detected in supernatants of liquid cultures or lysates of whole bacterial cells. however, no studies have ever tried to assay vaca produced in the human stomach. we applied a very sensitive and simple method, bead-elisa, to detect vaca in gastric juice. | 2002 | 12390207 |
| numerical chromosomal abnormality in gastric malt lymphoma and diffuse large b-cell lymphoma. | we investigated numerical chromosomal abnormalities, using the fluorescence in situ hybridization (fish) method, in gastric mucosa-associated lymphoid tissue (malt) lymphoma and diffuse large b-cell lymphoma (dlbl). we also compared the histopathological findings, including the presence or absence of helicobacter pylori infection, with the analytical results. | 2002 | 12375141 |
| increased in-vitro and in-vivo biological activity of lipopolysaccharide extracted from clinical low virulence vaca genotype helicobacter pylori strains. | helicobacter pylori infection in man is associated with chronic gastritis and peptic ulcer disease. the virulence factors of the species are still under investigation. among these, the lipopolysaccharide (lps) is a potential pathogenic factor of the micro-organism, whose biological activity can be estimated by immunological parameters. the aim of this study was to determine the ability of pure lps extracted from clinical isolates of h. pylori to induce mitogenicity, secretion of tumour necrosis ... | 2002 | 12358068 |
| effects of rabeprazole, lansoprazole and omeprazole on intragastric ph in cyp2c19 extensive metabolizers. | to investigate the inhibitory effects on gastric acid secretion of three proton pump inhibitors, omeprazole, lansoprazole and rabeprazole, using a three-way crossover design in healthy helicobacter pylori-negative,s-mephenytoin 4'-hydroxylase (cyp2c19) homo- and hetero-extensive metabolizers. | 2002 | 12269976 |
| hp (2-20) derived from the amino terminal region of helicobacterpylori ribosomal protein l1 exerts its antifungal effects by damaging the plasma membranes of candida albicans. | the fungicidal effects of the peptide hp (2-20). derived from the n-terminal sequence of helicobacter pylori ribosomal protein l1 (rpl1). have been investigated. hp (2-20) displays a strong fungicidal activity against various fungi, without haemolytic activity against human erythrocyte cells, and the fungicidal activity is inhibited by ca2+ and mg2+ ions. in order to investigate the fungicidal mechanism(s) of hp (2-20). the amount of intracellular trehalose was measured in c. albicans. it was fo ... | 2002 | 12212808 |
| [role of sera from peptic ulcer patients in cell proliferation of human gastric carcinoma]. | this study aimed at the relationship of helicobacter pylori infection to gastric carcinoma pathogenesis. forty-nine serum samples from patients with gastric and duodenal ulcer and 20 serum sample from normal subjects were collected for the assessment of serum gastrin by radioimmunoassay (ria) and serum igg, iga and igm antibodies against h. pylori by elisa respectively. the patients, serum samples were divided into four groups for observations on whether the sera would affect the cell proliferat ... | 1999 | 12212290 |
| [effect of human serum on the growth of helicobacter pylori]. | to investigate whether sheep blood could be replaced with human serum or fetal calf serum for helicobacter pylori(hp) culture, hp was inoculated onto the culture plates containing 7% of sheep blood, human serum, or fetal calf serum respectively. the colonies were counted after 5 days of culture. similar culture results were obtained in the plates containing sheep blood, human serum, or fetal calf serum respectively. no effect of anti-hp-igg antibody in human serum on the growth of hp was found ( ... | 2000 | 12206006 |
| effect of weissella confusa strain pl9001 on the adherence and growth of helicobacter pylori. | viable and nonviable weissella confusa strain pl9001 inhibited the binding of helicobacter pylori to human gastric-cell line mkn-45 cells by more than 90%. spent culture supernatant of pl9001 rapidly decreased the viability of h. pylori, rupturing cell walls. the results suggest that pl9001 is a probiotic that can reduce the infectivity and persistence of h. pylori. | 2002 | 12200324 |
| pathogenesis of helicobacter pylori infection. | five years after publication of the complete genome sequence of helicobacter pylori, research interest is shifting from the descriptive association of virulence factors with clinical outcome in infected patients to the molecular mechanisms of virulence factor action. this is particularly noticeable for vaca and caga, for both of which detailed understanding of the interaction with host signalling pathways has accumulated over the last year. the role of h. pylori lewis antigens for clinical outco ... | 2002 | 12197905 |
| [expression of pi glutathione s-transferase in intestinal metaplasia and its relationship with helicobacter pylori infection]. | to study the dynamic change of glutathione s- transferase pi (gst-pi) in normal gastric mucosa, gastric mucosa with intestinal metaplasia (im) and gastric cancer and to investigate the relationship between human carcinogen detoxification system and the virulence of helicobacter pylori(h.pylori) in the stage of im. | 2002 | 12194793 |
| inhibitory effect of lactobacillus acidophilus on helicobacter pylori in peptic ulcer patients: in vitro study. | lactobacillus acidophilus (l. acidophilus) have been introduced into many fermented dairy products. the presence of l. acidophilus appears to decrease helicobacter pylori (h. pylori) density in the human stomach and could enhance antibiotic therapy for h. pylori eradication. this study was designed to determine the optimal density of l. acidophilus that has a maximum inhibitory effect on h. pylori in peptic ulcer patients. to determine whether l. acidophilus has an inhibitory effect on h. pylori ... | 2002 | 12188456 |
| expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, helicobacter pylori infection, and vascular endothelial growth factor expression. | cyclooxygenase-2 (cox-2) expression may contribute to the synthesis of prostanoids, which have been related to carcinogenesis and tumor progression. it is well known that the gastric remnant is at greater risk of the development of gastric cancer than is the whole stomach; incidence rates for gastric cardia adenocarcinoma are rising in the united states and europe. our objective was to determine the involvement of cox-2 in primary and remnant gastric cancer tissues as well as in adjacent noncanc ... | 2002 | 12173384 |
| relation of helicobacter pylori to mucins and mucous cells in human stomach. | 2000 | 12167291 | |
| synchronous primary adenocarcinoma, mucosa-associated lymphoid tissue lymphoma and a stromal tumor in a helicobacter pylori-infected stomach. | we report the case of a 78-year-old man with helicobacter pylori infection and three primary neoplasms of the stomach: adenocarcinoma, mucosa-associated lymphoid tissue (malt) lymphoma and a gastrointestinal stromal cell tumor. helicobacter pylori infection is associated with gastric carcinoma and malt lymphoma, although their simultaneous occurrence is rare. gastrointestinal stromal cell tumors have not been associated with infection to date. this appears to be the first report of the synchrono ... | 2002 | 12167128 |
| helicobacter pylori virulence genes and host il-1rn and il-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia. | helicobacter pylori infection outcome might depend on genotypic polymorphisms of both the bacterium and the host. we ascertained: (1) the functionality of h. pylori oipa gene; (2) the polymorphism of the hostinterleukin (il-1beta) gene (-31 c/t) and of the il-1rn gene (intron 2 vntr); (3) the association between the above genes and the histological and pathological outcome of h. pylori infection. one hundred and sixty-five h. pylori positive and 137 h. pylori negative subjects (23 gastric adenoc ... | 2002 | 12161099 |
| new strategies for the prevention and treatment of helicobacter pylori infection. | helicobacter pylori infects the stomach of > 50% of the human population worldwide, with higher prevalence in the developing countries. a strict correlation between h. pylori infection and gastroduodenal diseases has been demonstrated, including gastritis, peptic ulcer and gastric cancer. current therapies against h. pylori consist of an antisecretory plus antibiotics. these therapies are effective in 80 - 90% of the cases; presently, no alternative therapies have been shown to give comparable o ... | 2002 | 12150706 |
| genome-scale metabolic model of helicobacter pylori 26695. | a genome-scale metabolic model of helicobacter pylori 26695 was constructed from genome sequence annotation, biochemical, and physiological data. this represents an in silico model largely derived from genomic information for an organism for which there is substantially less biochemical information available relative to previously modeled organisms such as escherichia coli. the reconstructed metabolic network contains 388 enzymatic and transport reactions and accounts for 291 open reading frames ... | 2002 | 12142428 |
| helicobacter pylori may survive ampicillin treatment in the remnant stomach. | helicobacter pylori (h. pylori) is a gram-negative curved rod-like or spiral bacterium that chronically infects the human gastric mucosa, and is a major risk factor for gastritis, gastric and duodenal ulcer and adenocarcinoma of the stomach. after partial gastrectomy, some patients may have persistent h. pylori infection for five years or more. in this study, we detected three bacteria, i.e., klebsiella pneumoniae, enterobacter aerogenes, and escherichia coli, in the gastric juice of patients wi ... | 2002 | 12139018 |
| helicobacter pylori hspa heat-shock protein gene cloning, expression and immunogenicity. | helicobacter pylori is the causative agent of gastritis and peptic ulcer in human. the heat-shock protein a (hspa)may stimulate the immunoresponse protecting human body against challenge of h.pylori. the gene encoding the structural a subunit of h.pylori heat-shock protein was amplified from h.pylori chromosomal dna by pcr, and was inserted in the prokaryotic expression vector pet-22b(+), and then was transformed into the bl-21(de3)e.coli strain to express the hspa recombinant protein. hspa gene ... | 1999 | 12136175 |
| cancer prevention and therapy with kiwifruit in chinese folklore medicine: a study of kiwifruit extracts. | kiwi gold fruits were extracted successively with hexane, acetone, methanol and 70% methanol, and further fractionated by silica gel and ods column chromatographies for the assays of various biological activities. five fractions h1, h2 (hexane extract), al, a2 (acetone extract) and m2 (methanol extract) showed selective cytotoxic activity against human oral tumor cell lines, which was more sensitive than human gingival fibroblasts. more hydrophilic fractions [70m3, 70m4, 70m5] of 70% methanol ex ... | 2002 | 12127237 |
| [association between helicobacter pylori caga strain infection and expression of cyclooxygenase 2 in gastric carcinoma]. | to observe the expression of cyclooxygenase 2 (cox-2) in tissues of human gastric cancer and explore the association between helicobacter pylori caga strain infection and the expression of cox-2 so as to provide a theoretical basis for early prevention of gastric cancer. | 2002 | 12126507 |
| randomized open trial for comparison of proton pump inhibitors in triple therapy for helicobacter pylori infection in relation to cyp2c19 genotype. | genetic polymorphism of cytochrome p450 (cyp) 2c19 influences the efficacy of helicobacter pylori eradication therapy with a proton pump inhibitor (ppi) and amoxicillin. however, in triple therapy (ppi plus amoxicillin and clarithromycin), little is known about the impact of cyp2c19 polymorphism, or the use of rabeprazole, which is not well metabolized by cyp2c19. the efficacy of three ppi (omeprazole, lansoprazole, and rabeprazole) in a 1-week triple regimen were compared in relation to cyp2c19 ... | 2002 | 12121503 |
| helicobacter pylori-induced activation of human endothelial cells. | helicobacter pylori infection causes active chronic inflammation with a continuous recruitment of neutrophils to the inflamed gastric mucosa. to evaluate the role of endothelial cells in this process, we have examined adhesion molecule expression and chemokine and cytokine production from human umbilical vein endothelial cells stimulated with well-characterized h. pylori strains as well as purified proteins. our results indicate that endothelial cells actively contribute to neutrophil recruitmen ... | 2002 | 12117971 |
| analysis of p53 mutations and helicobacter pylori infection in human and animal models. | p53 gene mutations are believed to play a critical role in the development of gastric carcinoma. we examined the relation between helicobacter pylori infection and p53 gene mutations of the gastric mucosa in human and animal models. | 2002 | 12109656 |
| interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in japan. | interleukin-1 beta (il-1beta) polymorphisms are associated with increased risk of gastric cancer in whites. this study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in japan. | 2002 | 12105837 |