Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| quadruple rescue therapy for helicobacter pylori infection after two treatment failures. | a standard third-line therapy for helicobacter pylori infection is lacking, and antimicrobial sensitivity data for patients who failed eradication therapy are often unavailable in clinical practice. we therefore designed the prospective study to assess the efficacy of levofloxacin, amoxicillin, bismuth and rabeprazole quadruple therapy as a third-line treatment for h. pylori infection. | 2008 | 18435764 |
| ccl28 is increased in human helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin a-secreting cells. | human helicobacter pylori infection gives rise to an active chronic gastritis and is a major risk factor for the development of duodenal ulcer disease and gastric adenocarcinoma. the infection is accompanied by a large accumulation of immunoglobulin a (iga)-secreting cells in the gastric mucosa, and following mucosal immunization only h. pylori-infected volunteers mounted a b-cell response in the gastric mucosa. to identify the signals for recruitment of gastric iga-secreting cells, we investiga ... | 2008 | 18426876 |
| histological heterogeneity and somatic mtdna mutations in gastric intraepithelial neoplasia. | somatic mutations of mitochondrial dna (mtdna) are associated with various types of human cancer. to elucidate their role in gastric carcinogenesis, we analyzed mutations in the displacement loop region of mtdna in 24 paraffin-embedded gastric intraepithelial neoplasias (formerly dysplasia) from a high gastric cancer risk area in northern italy. helicobacter pylori infection was assessed by histological examination (giemsa staining). gastritis was classified according to the guidelines of the up ... | 2008 | 18425082 |
| tnf-alpha-inducing protein, a carcinogenic factor secreted from h. pylori, enters gastric cancer cells. | tnf-alpha inducing protein (tip alpha) is secreted from helicobacter pylori (h. pylori): it is a potent inducer of tnf-alpha and chemokine genes, mediated through nf-kappab activation, and it also induces tumor-promoting activity in bhas 42 cells. to investigate the carcinogenic mechanisms of h. pylori with tip alpha, we first examined how tip alpha acts on gastric epithelial cells. we found that fluorescent-tip alpha specifically bound to, and then entered, the cells in a dose- and temperature- ... | 2008 | 18412243 |
| role of type iv secretion in helicobacter pylori pathogenesis. | helicobacter pylori is a highly successful human-specific gastric pathogen that colonizes more than half the world's population. infection with this bacterium can induce gastric pathologies ranging from chronic gastritis to peptic ulcers and even cancer. virulent h. pylori isolates harbour the cag (cytotoxin-associated genes) pathogenicity island, a 40 kb stretch of dna that encodes components of a type iv secretion system (t4ss). this t4ss forms a pilus for the injection of virulence factors in ... | 2008 | 18410539 |
| the effect of helicobacter pylori eradication treatment on the muc 1 and lewis antigens level in human gastric juice: a preliminary study. | helicobacter pylori is considered as a causative agent of gastritis, duodenal and gastric ulcers, and gastric cancer. during inflammation, association of the pathogen of gastric epithelial cells and mucins is considered important. it was postulated that lewis b structures of secretory muc 5ac mucin can be a receptor for the bacterium. some authors also suggest that epithelial muc 1 mucin may be implicated in the mechanism of infection. the main aim of our work was to support this last suggestion ... | 2008 | 18409003 |
| the frequency of lymphocytic gastritis in baboons. | in 1985, two independent reports highlighted a novel subtype of chronic inflammation in the gastric mucosa, characterized by the intraepithelial lymphocytic infiltration (ili) both in the surface and the foveolar epithelium. the disease, subsequently called lymphocytic gastritis (lg) is a rare form of gastritis (0.8%-1.6% of cases), with unclear pathogenesis. more recently, lg was recorded in pigs and in non-human primates. | 2008 | 18396790 |
| structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes. | biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate (ipp) and dimethylallyl diphosphate (dmapp), from three acetyl coa moieties through mevalonate was studied extensively in the 1950s. for several decades, the mevalonate paradigm reigned supreme and a mevalonate origin was attributed to a growing number of natural products, in many cases erroneously. besides this biosynthetic pathway, the existence of a second one leading to ipp and dmapp through 1-deoxy-d-xylulose 5-phos ... | 2008 | 18393884 |
| polymorphisms of death pathway genes fas and fasl and risk of premalignant gastric lesions. | tumorigenesis is a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the fas receptor-ligand system is a key regulator of apoptosis. the aim of this study was to investigate whether functional polymorphisms of death pathway genes (fas and fasl) are associated with the development of gastric atrophy and intestinal metaplasia. | 2008 | 18383830 |
| conjugated linoleic acids produced by lactobacillus dissociates ikk-gamma and hsp90 complex in helicobacter pylori-infected gastric epithelial cells. | although probiotics have been reported to reduce the gastric inflammatory response to helicobacter pylori infection, little information is available regarding the molecular mechanisms behind this reduction. this study investigates the role of conjugated linoleic acids (cla) produced by probiotics in interactions of ikappab kinase (ikk) and heat shock protein 90 (hsp90) to activate the nuclear factor-kappab (nf-kappab) signaling pathway in human gastric epithelial cells infected with h. pylori. c ... | 2008 | 18347582 |
| the distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients. | this study used monoclonal antibody specific for 4-hydroxynonenal (hne)-histidine to evaluate immunohistochemical distribution of hne-protein adducts in gastric mucosa biopsies of 52 peptic ulcer patients (all positive for h. pylori) and of 20 healthy volunteers (eight positive and 12 negative for h. pylori). hne-modified proteins were present in glandular epithelium in all subjects, both patients with duodenal peptic ulcer and healthy subjects. hence, the presence of hne did not appear to be re ... | 2008 | 18344114 |
| cdh1 gene polymorphisms, smoking, helicobacter pylori infection and the risk of gastric cancer in the european prospective investigation into cancer and nutrition (epic-eurgast). | despite declining incidence rates, gastric cancer (gc) is a major cause of death worldwide. e-cadherin is an adhesion molecule that is thought to be involved in gc. germline mutations in the e-cadherin gene (cdh1) have been identified in hereditary diffuse gc. also, a promoter polymorphism at position -160 c/a has been suggested to lead to transcriptional down regulation and has been shown to affect gc risk in some studies. however, very little information exists on the gc risk association of ot ... | 2008 | 18342503 |
| the alpha and beta classes carbonic anhydrases from helicobacter pylori as novel drug targets. | helicobacter pylori (h. pylori) successfully resides in the human stomach in highly acidic conditions, causing a variety of gastroduodenal lesions, including gastric ulcer, gastric cancer and malt lymphoma. for acid acclimation of h. pylori, two types of enzymes, urease and carbonic anhydrase (ca), play a central role. they cooperatively function to maintain neutral ph in the bacterial cytoplasm and periplasm. the genome project of h. pylori identified two different classes of ca with different ... | 2008 | 18336307 |
| significantly elevated helicobacter pylori density and different genotype distribution in erosions as compared with normal gastric biopsy specimen detected by quantitative real-time pcr. | determination of the local densities of helicobacter pylori and its genotypic variations in gastric biopsy specimens by using novel real-time pcr-based methods could support the precise diagnosis and understanding of h. pylori infections. | 2008 | 18334874 |
| chronic autoimmune thyroiditis (hashimoto's thyroiditis) in patients with malt lymphoma. | autoimmune diseases have been implicated in the genesis of malt lymphoma of various localizations. the development of thyroidal malt lymphoma has been described as an adverse event in patients suffering from long-standing chronic autoimmune thyroiditis (cat, hashimoto's thyroiditis). the percentage and possible association between cat and extrathyroidal malt lymphoma, however, have not been assessed so far. | 2008 | 18334510 |
| helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. | we have characterized the adaptations of helicobacter pylori to a rarely captured event in the evolution of its impact on host biology-the transition from chronic atrophic gastritis (chag) to gastric adenocarcinoma-and defined the impact of these adaptations on an intriguing but poorly characterized interaction between this bacterium and gastric epithelial stem cells. bacterial isolates were obtained from a single human host colonized with a single dominant strain before and after his progressio ... | 2008 | 18332421 |
| effect of eradication of helicobacter pylori on the histology and cellular phenotype of gastric intestinal metaplasia. | eradication of helicobacter pylori appears to reduce gastric cancer incidence. we examined the effect of successful h pylori therapy on histology, phenotype of gastric intestinal metaplasia (gim) (complete vs incomplete), and expression of several biomarkers related to carcinogenesis. | 2008 | 18321787 |
| pseudomyxoma peritonei: is disease progression related to microbial agents? a study of bacteria, muc2 and muc5ac expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. | pseudomyxoma peritonei (pmp) is characterized by peritoneal tumors arising from a perforated appendiceal adenoma or adenocarcinoma, but associated entry of enteric bacteria in the peritoneum has not been considered as a cofactor. because gram-negative organisms can upregulate muc2 mucin gene expression, we determined whether bacteria were detectable in pmp tissues. | 2008 | 18299935 |
| identification of proteins related to nickel homeostasis in helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis. | helicobacter pylori (h. pylori) is a widespread human pathogen causing peptic ulcers and chronic gastritis. maintaining nickel homeostasis is crucial for the establishment of h. pylori infection in humans. we used immobilized-nickel affinity chromatography to isolate ni-related proteins from h. pylori cell extracts. two-dimensional gel electrophoresis and mass spectrometry were employed to separate and identify twenty two ni-interacting proteins in h. pylori. these ni-interacting proteins can be ... | 2008 | 18288244 |
| difference of p53aip1 mrna expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with helicobacter pylori. | to examine the significance of alteration of p53-regulated apoptosis-induced protein 1 (p53aip1) expression in gastric carcinogenesis in patients with helicobacter pylori infection. | 2008 | 18277906 |
| yeast of the oral cavity is the reservoir of heliobacter pylori. | frequent occurrence of helicobacter pylori in the human gastrointestinal tract and its persistence due to unsuccessful antimicrobial therapy might be related to a stage in the life cycle of h. pylori in which the bacterium establishes itself as an intracellular symbiont in yeast. in this study, occurrence of non-culturable h. pylori in the oral yeast was assessed by targeting vacuolating cytotoxin a (vaca s1s2) and ureab genes in the total dnas of yeasts. | 2008 | 18266659 |
| autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora. | peptide hormones synthesized in gastrointestinal and adipose tissues in addition to neuropeptides regulate appetite and body weight. previously, autoantibodies directed against melanocortin peptides were found in patients with eating disorders; however, it remains unknown whether autoantibodies directed against other appetite-regulating peptides are present in human sera and whether their levels are influenced by gut-related antigens. | 2008 | 18262391 |
| helicobacter pylori infection affects toll-like receptor 4 expression in human gastric mucosa. | toll-like receptor 4 (tlr4), which requires a helper molecule, md-2, is a main receptor for lipopolysaccharide (lps) from gram-negative bacteria. the expression of tlr4 in h. pylori infection in human gastric mucosa, however, is unclear. the aim of this study was to determine the effect of h. pylori infection on the tlr4 and md-2 expression in human gastric mucosa. | 2007 | 18251133 |
| h pylori (caga) and epstein-barr virus infection in gastric carcinomas: correlation with p53 mutation and c-myc, bcl-2 and bax expression. | to investigate the interrelationship between h pylori and epstein-barr virus (ebv) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-myc, bcl-2 and bax expression. | 2008 | 18240345 |
| chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: a fluorescent in situ hybridization study using a tissue microarray approach. | extranodal marginal zone b-cell lymphomas (mucosa-associated lymphoid tissue [malt] lymphomas) of the gastrointestinal tract have been known to have characteristic chromosomal aberrations including trisomies of chromosomes 3, 12, and 18. however, knowledge of the clinical significance of cytogenetic changes in malt lymphomas is still limited. in the present study, the frequency of the numeric and structural aberrations of the chromosomes 1, 3, 12, 18 and x and of the malt1 gene as well as their ... | 2008 | 18234275 |
| chronic active gastritis in x-linked lymphoproliferative disease. | gastric lesions in primary constitutive immune deficiencies include multifocal atrophic gastritis, erosive pangastritis, and a pattern of gastric lesions reminiscent of graft-versus-host disease. we describe the genetic anomalies in 2 monozygotic twins with an x-linked lymphoproliferative disease (xlp; mim 308240), a rare familial setting of high susceptibility to epstein-barr virus (ebv). since early childhood, both twin brothers exhibited a severe chronic active atrophic pangastritis. a germli ... | 2008 | 18223336 |
| long-term follow-up of gastrectomized patients with mucosa-associated lymphoid tissue lymphoma: need for a revisit of surgical treatment. | gastric mucosa-associated lymphoid tissue (malt) lymphoma is characterized by multifocality of the tumors, which often scatter over the mucosa of the stomach and adjacent upper gastrointestinal tract, and is therefore theoretically not curable by surgical resection. | 2008 | 18216531 |
| discovering differential protein expression caused by caga-induced erk pathway activation in ags cells using the seldi-proteinchip platform. | to identify the protein expression differences related to the caga-induced erk pathway activation in ags cells. | 2008 | 18203287 |
| helicobacter pylori protein response to human bile stress. | the ability of helicobacter pylori to tolerate bile is likely to be important for its colonization and survival in the gastrointestinal tract of humans. as bile can be acidified after reflux into the low ph of the human stomach, the inhibitory effect of fresh human bile with normal appearance on h. pylori before and after acidification was tested first. the results showed that acidification of bile attenuated its inhibitory activity towards h. pylori. next, the protein profiles of h. pylori unde ... | 2008 | 18201979 |
| helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor 2. | recently, it has been shown that serine proteases derived from microorganisms stimulate epithelial cells to produce inflammatory mediators through protease-activated receptor (par). we investigated the involvement of par2 in the interleukin (il)-8 production by helicobacter pylori-infected gastric epithelial cells. | 2008 | 18196899 |
| transgenic expression of helicobacter pylori caga induces gastrointestinal and hematopoietic neoplasms in mouse. | infection with caga-positive helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (malt) lymphoma of b cell origin. the caga-encoded caga protein is delivered into gastric epithelial cells via the bacterial type iv secretion system and, upon tyrosine phosphorylation by src family kinases, specifically binds to and aberrantly activates shp-2 tyrosine phosphatase, a bona fide oncoprotein in human malignancies. caga also elicits junctional and ... | 2008 | 18192401 |
| [a case of lung cancer with idiopathic thrombocytopenic purpura effectively treated for helicobacter pylori]. | a 58-year-old man with cough and bloody sputum was admitted because of right lung tumor and thrombocytopenia. idiopathic thrombocytopenic purpura (itp) was diagnosed. for treatment of itp, he was treated with platelet transfusions, intravenous gamma-globulin and oral prednisolone. however, the platelet count did not completely improved. since a relationship between itp and helicobacter pylori (hp) infection has been reported, and result of urease test was positive, the patient was treated by hp ... | 2007 | 18186249 |
| il-4 -588c>t polymorphism and il-4 receptor alpha [ex5+14a>g; ex11+828a>g] haplotype concur in selecting h. pylori caga subtype infections. | the th2 cytokine il-4 might limit h. pylori associated gastric inflammation and favour h. pylori clearance. the aim of the study was to verify whether il-4 -588c>t snp, or two snps of the gene coding the alpha chain of il-4 receptor (il-4ra ex5+14a>g, il-4ra ex11+828a>g) considered singly or as haplotypes, are correlated with h. pylori virulence genes or h. pylori associated diseases. | 2008 | 18179773 |
| polymorphisms in toll-like receptor genes and risk of cancer. | host genetic factors are emerging as key determinants of disease risk for many cancers. identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. the toll-like receptors are important members of the host's innate immune response and their genes have been found to be polymorphic. this genetic variation allows for a more intricate repertoire that enables the host to withstand microbial challenges. while this may be advant ... | 2008 | 18176606 |
| role of toll-like receptors in gastrointestinal malignancies. | mounting evidence supports the tenet that innate immune responses to luminal microbes participate in the development of gastrointestinal malignancies. the gastrointestinal tract is relatively unique in that it has evolved in the presence of diverse enteric microflora. intestinal flora is required to develop a normal adaptive immune response in the periphery. with the characterization of the innate immune system, we have begun to understand the adaptations the intestine has made to the microbiota ... | 2008 | 18176605 |
| effects of helicobacter pylori infection on gastric mucin expression. | this study was performed to determine the gastric distributions of muc5ac and muc6 depending on helicobacter pylori (h. pylori) infection, and to evaluate whether the expressions of muc5 and muc6 change in h. pylori-associated gastroduodenal diseases. in addition, muc5ac and muc6 expressional changes were investigated before and after h. pylori eradication. | 2008 | 18097286 |
| other immune thrombocytopenias. | immune thrombocytopenic purpura (itp) can be classified as primary (known also as idiopathic thrombocytopenic purpura) or as secondary to an underlying condition such as a malignant or nonmalignant disorder. commonly occurring conditions associated with secondary itp include lymphoproliferative disorders (chronic lymphocytic leukemia [cll], hodgkin's disease and non-hodgkin's lymphomas), autoimmune collagen vascular diseases (systemic lupus erythematosus [sle], thyroid disease, antiphospholipid ... | 2007 | 18096469 |
| predictive role of nuclear factor-kappab activity in gastric cancer: a promising adjuvant approach with caffeic acid phenethyl ester. | the biologic significance of nuclear factor-kappab (nf-kappab) activation in human gastric cancer is unclear. we clarify the clinical significance of nf-kappab activation and its relationship to helicobacter pylori infection, a well-known pathogenesis of gastric cancer. moreover, we examine the effects and underlying mechanisms induced by caffeic acid phenethyl ester (cape), an inhibitor of nf-kappab, for gastric carcinoma. | 2007 | 18090157 |
| a new algorithm for cluster analysis of genomic methylation: the helicobacter pylori case. | the genomic methylation analysis is useful to type bacteria that have a high number of expressed type ii methyltransferases. methyltransferases are usually committed to restriction and modification (r-m) systems, in which the restriction endonuclease imposes high pressure on the expression of the cognate methyltransferase that hinder r-m system loss. conventional cluster methods do not reflect this tendency. an algorithm was developed for dendrogram construction reflecting the propensity for con ... | 2008 | 18086685 |
| association of toll-like receptor-4 (asp299gly and thr399ileu) gene polymorphisms with gastritis and precancerous lesions. | a toll-like receptor-4 (tlr-4) asp299gly and thr399ileu substitution reduces responsiveness to helicobacter pylori (h. pylori) lipopolysaccharide. caga+ strains of h. pylori are known to be associated with gastroduodenal diseases. therefore we aimed to evaluate association of tlr-4 substitutions and caga seropositivity with gastritis and precancerous lesions in a northern indian population. after upper gastrointestinal endoscopy, 130 rapid urease test (rut)-positive patients with nonulcer dyspep ... | 2007 | 18082569 |
| evidence for cancer-associated expression of nadph oxidase 1 (nox1)-based oxidase system in the human stomach. | helicobacter pylori infection has been suggested to stimulate expression of the nadph oxidase 1 (nox1)-based oxidase system in guinea pig gastric epithelium, whereas nox1 mrna expression has not yet been documented in the human stomach. pcr of human stomach cdna libraries showed that nox1 and nox organizer 1 (noxo1) messages were absent from normal stomachs, while they were specifically coexpressed in intestinal- and diffuse-type adenocarcinomas including signet-ring cell carcinoma. immunohistoc ... | 2007 | 18037128 |
| [carbamazepine and clarithromycin: a clinically relevant drug interaction]. | carbamazepine is associated with clinically relevant drug interactions especially with macrolide antibiotics such as troleandomycin and erythromycin. these drugs inhibit the metabolism of carbamazepine. clarithromycin, a macrolide antibiotic similar to erythromycin, is widely used to treat respiratory tract infections and is used for the treatment of atypical mycobacterial infections and helicobacter pylori-associated peptic ulcer disease. | 2007 | 18033049 |
| primary hepatic low-grade b-cell lymphoma of malt-type associated with helicobacter pylori infection. | primary marginal zone b-cell lymphoma of mucosa associated tissue (malt) type in the liver is extremely rare, and the etiology of this disease is yet to be clarified. we present the first report of a primary hepatic low-grade lymphoma of malt-type associated with helicobacter pylori (h. pylori) infection. a 64-year-old man was referred to our hospital for the treatment of early gastric carcinoma. he underwent distal gastrectomy with regional lymph node dissection. in the operation, several small ... | 2007 | 18019744 |
| gastric gelatinase b/matrix metalloproteinase-9 is rapidly increased in helicobacter felis-induced gastritis. | it has previously been shown that matrix metalloproteinase-9 (mmp-9) levels, originating from macrophages, are considerably increased in human helicobacter pylori-associated gastritis. here, the early kinetics of the mmp-9 response resulting from helicobacter infection in c57bl/6 and mmp-9 knock-out mice using the murine helicobacter felis model were examined. h. felis infection induced severe gastritis in the murine stomach at just 2 weeks after infection. before gastritis, an increase was obse ... | 2008 | 17995959 |
| novel protein antigen (jhp940) from the genomic plasticity region of helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages. | the plasticity region of the helicobacter pylori genome comprises strain-specific gene loci. we performed genotyping and functional biology analysis of one such locus (jhp940) that was previously found to be functionally unknown but present in gastric cancer-associated strains from many different countries. we found its geographic prevalence to be independent of caga presence and disease status. cloning, expression, and purification of jhp940 revealed a novel, approximately 36-kda protein in a b ... | 2008 | 17993522 |
| how to influence health providers. | in spite of the recognition that helicobacter pylori is responsible for most duodenal ulcer and peptic ulcer and that it is the underlying cause of most gastric cancer, little or no attention has been paid to its effect upon public health and in particular no measures have been put in place to address them. for over 20 years relatively inexpensive and noninvasive testing and treatment have been available, but no country has introduced a "screen-and-treat" policy, and relatively little research h ... | 2007 | 17991182 |
| vitamin c supplementation does not protect l-gulono-gamma-lactone oxidase-deficient mice from helicobacter pylori-induced gastritis and gastric premalignancy. | in human studies, low vitamin c intake has been associated with more severe helicobacter pylori gastritis and a higher incidence of gastric cancer. however, vitamin c supplementation has not been definitively shown to protect against gastric cancer. using vitamin c-deficient b6.129p2-gulo(tm1umc/mmcd) (gulo(-/-)) mice lacking l-gulono-gamma-lactone oxidase, we compared gastric lesions and th1 immune responses in h. pylori-infected gulo(-/-) mice supplemented with low (33 mg/l) or high (3,300 mg/ ... | 2008 | 17990318 |
| enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from helicobacter pylori. | cystathionine gamma-synthase (cgs) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human. in this report, we identified a new metb gene from helicobacter pylori strain ss1, and the recombinant h. pylori cystathionine gamma-synthase (hpcgs) was successfully cloned, expressed and purified in escherichia coli system. enzymatic study of hpcgs indicated that the k(m) and k(cat)/k(m) values against the s ... | 2008 | 17981822 |
| identification, structure and mode of action of a new regulator of the helicobacter pylori hp0525 atpase. | helicobacter pylori is one of the world's most successful human pathogens causing gastric ulcers and cancers. a key virulence factor of h. pylori is the cag pathogenicity island, which encodes a type iv secretion system. hp0525 is an essential component of the cag system and acts as an inner membrane associated atpase. hp0525 forms double hexameric ring structures, with the c-terminal domains (ctds) forming a closed ring and the n-terminal domains (ntds) forming a dynamic, open ring. here, the c ... | 2007 | 17972918 |
| periodontitis may increase the risk of peripheral arterial disease. | the aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (pad). | 2008 | 17964192 |
| toll-like receptor 2 (tlr) -196 to 174del polymorphism in gastro-duodenal diseases in japanese population. | toll-like receptors (tlrs) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. -196 to -174del polymorphism affects the tlr2 gene and alters its promoter activity. we investigated the influence of tlr2 -196 to -174del polymorphism on the risk of gastro-duodenal diseases, on the severity of helicobacter pylori-induced gastritis in a japanese population. the study was performed on 309 patients with abdominal discomfort ... | 2008 | 17934843 |
| cyp2c19 pharmacogenomics associated with therapy of helicobacter pylori infection and gastro-esophageal reflux diseases with a proton pump inhibitor. | proton pump inhibitors (ppis), such as omeprazole, lansoprazole and rabeprazole, are metabolized by cyp2c19 in the liver. there are genetic differences in the activity of this enzyme. genotypes of cyp2c19 are classified into three groups, rapid metabolizer (rm: *1/*1), intermediate metabolizer (im: *1/*x) and poor metabolizer (pm: *x/*x) (*1 and 'x' represent the wild-type and mutant allele, respectively). the pharmacokinetics and pharmacodynamics of ppis differ among three different cyp2c19 gen ... | 2007 | 17924835 |
| expanding the helicobacter pylori genetic toolbox: modification of an endogenous plasmid for use as a transcriptional reporter and complementation vector. | helicobacter pylori is an important human pathogen. however, the study of this organism is often limited by a relative shortage of genetic tools. in an effort to expand the methods available for genetic study, an endogenous h. pylori plasmid was modified for use as a transcriptional reporter and as a complementation vector. this was accomplished by addition of an escherichia coli origin of replication, a kanamycin resistance cassette, a promoterless gfpmut3 gene, and a functional multiple clonin ... | 2007 | 17921278 |
| muc1 mucin limits both helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. | the muc1 mucin is expressed on the cell surface of epithelial cells lining the gastric mucosa. epidemiologic studies suggest that functional allelic variations in the muc1 gene may play a role in human susceptibility to helicobacter pylori-associated pathologies, including gastric adenocarcinoma. we have evaluated the impact of muc1 expression on the colonization and pathogenesis of gastric helicobacter infections. | 2007 | 17919495 |
| host response to helicobacter pylori infection before initiation of the adaptive immune response. | helicobacter pylori persistently colonizes the human stomach. in this study, immune responses to h. pylori that occur in the early stages of infection were investigated. within the first 2 days after orogastric infection of mice with h. pylori, there was a transient infiltration of macrophages and neutrophils into the glandular stomach. by day 10 postinfection, the numbers of macrophages and neutrophils decreased to baseline levels. by 3 weeks postinfection, an adaptive immune response was detec ... | 2007 | 17919297 |
| dynamic colonization of helicobacter pylori in human gastric mucosa. | to investigate the dynamic behaviour of helicobacter pylori in the colonization of the human gastric mucosa in patients previously treated for h. pylori infection. | 2008 | 17918004 |
| [construction, expression and purification of ureb-omp11 fusion protein of helicobacter pylori and its immunocompetence]. | to construct h.pylori vaccine candidate strain expressing ureb-omp11 recombinant fusion protein of h.pylori. to express and purify the fusion protein ureb-omp11 and to determine its immunocompetence. | 2007 | 17908495 |
| activation of human neutrophils with helicobacter pylori and the role of toll-like receptors 2 and 4 in the response. | the innate immune response to helicobacter pylori infection is beginning to be understood and recent works support a role for toll-like receptors (tlrs). our aim was to study the response of human neutrophils to h. pylori and to elucidate the role of tlr2 and tlr4. neutrophils from healthy h. pylori-negative volunteers were cocultured with h. pylori 26695 strain. the release of il-8, il-1beta, tumor necrosis factor (tnf)-alpha and il-10 was measured. the role of tlr2 and tlr4 was investigated wi ... | 2007 | 17892476 |
| primary gastrointestinal lymphoma: spectrum of imaging findings with pathologic correlation. | gastrointestinal lymphoma is an uncommon disease but is the most frequently occurring extranodal lymphoma and is almost exclusively of non-hodgkin type. primary gastrointestinal lymphoma most commonly involves the stomach but can involve any part of the gastrointestinal tract from the esophagus to the rectum. risk factors for the development of gastrointestinal lymphoma include helicobacter pylori infection, immunosuppression after solid organ transplantation, celiac disease, inflammatory bowel ... | 2007 | 17848697 |
| clarithromycin resistance, tumor necrosis factor alpha gene polymorphism and mucosal inflammation affect h. pylori eradication success. | several bacterial and host-related factors concur in causing helicobacter pylori eradication failure. we ascertained the role of bacterial virulence genes (caga, vaca), clarithromycin resistance [cla(r), 23s ribosomal rna (rrna) mutations], host polymorphism of cyp2c19 (polyphosphoinositide, ppi, metabolism) and of the cytokines il-1b-31c>t, il-1rn vntr, ifn-gamma+874a>t, tnf-alpha-1031t>c, tnf-alpha-857c>t, tnf-alpha-376g>a, tnf-alpha-308g>a, tnf-alpha-238g>a, il-10-1082a>g, il-10-819c>t, il-10 ... | 2007 | 17846855 |
| association of myeloperoxidase -463 g/a polymorphism with clinical outcome of helicobacter pylori infection in iranian patients with gastrointestinal diseases. | polymorphisms in the immune related genes are important in the clinical outcome of helicobacter pylori infection. myeloperoxidase -463 g/a polymorphism has been shown to reduce enzyme expression and activity. | 2007 | 17767014 |
| helicobacter pylori induces ccl20 expression. | ccl20 attracts immature dendritic cells and memory t cells and plays a role on mucosal surfaces in inflammation. however, whether helicobacter pylori infection induces ccl20 in human gastric epithelial cells remains to be determined. the aim of this study was to analyze the molecular mechanism of h. pylori-induced ccl20 expression. expression of ccl20 mrna was assessed by reverse transcription-pcr. five normal and five h. pylori-infected gastric tissue samples were stained immunohistochemically ... | 2007 | 17724069 |
| overexpression of helicobacter pylori-associated urease mrnas in human gastric cancer. | urease is involved in helicobacter pylori infection and survival in acid circumference. this study explored the overexpression of h. pylori-associated urease mrnas in human gastric cancers by using a well-established membrane array analysis method in our lab. analysis of 30 gastric cancer tissue specimens and 30 paired adjacent normal tissues demonstrated that urease genes involved in h. pylori infection were upregulated in gastric cancer tissues. urea, g, and i are predominant genotypes found i ... | 2007 | 17716001 |
| helicobacter pylori in the palatine tonsils of patients with iga nephropathy compared with those of patients with recurrent pharyngotonsillitis. | helicobacter pylori infection is acquired by oral ingestion. however, the morphology and microscopic localization of h pylori in the human oral cavity and pharynx are unknown. in the present study, we performed immunohistochemistry, immunoelectron microscopy, in situ hybridization, and polymerase chain reaction to identify h pylori in the palatine tonsils of 32 patients with immunoglobulin a nephropathy (igan) and 141 patients with recurrent pharyngotonsillitis (rpt). h pylori in coccoid form wa ... | 2007 | 17714758 |
| expression of helicobacter pylori virulence factors and associated expression profiles of inflammatory genes in the human gastric mucosa. | helicobacter pylori virulence factors have been suggested to be important in determining the outcome of infection. the h. pylori adhesion protein baba2 is thought to play a crucial role in bacterial colonization and in induction of severe gastric inflammation, particularly in combination with expression of caga and vaca. however, the influence of these virulence factors on the pathogenesis of h. pylori infection is still poorly understood. to address this question, the inflammatory gene expressi ... | 2007 | 17709414 |
| effect of mdr1 c3435t polymorphism on cure rates of helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to cyp 2c19 genotypes and 23s rrna genotypes of h. pylori. | polymorphism in mdr1 is associated with variation in the plasma level of a proton pump inhibitor. | 2007 | 17697203 |
| genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome p450 2c9 polymorphisms. | several nonsteroidal anti-inflammatory drugs (nsaids) are metabolized by the cytochrome p450 2c9 (cyp2c9). two common variants of the cyp2c9 gene (cyp2c9*2 and *3) were reported to significantly affect the activity of the cyp2c9 enzyme. the aim of this study was to evaluate the impact of cyp2c9 polymorphisms on the risk of gastroduodenal bleeding in acute nsaid users. | 2007 | 17681167 |
| improved in vitro model systems for gastrointestinal infection by choice of cell line, ph, microaerobic conditions, and optimization of culture conditions. | commonly used in vitro infection cultures do not mimic the human gastrointestinal tract with regard to ph and microaerobic conditions. furthermore, despite the importance of mucin-helicobacter interactions, the cell lines used have not been selected for appropriate mucin expression. to make in vitro studies more applicable to human disease, we have developed coculture methods taking these factors into account. | 2007 | 17669108 |
| isolation and characterization of human gastric cell lines with stem cell phenotypes. | the aim of this study was to develop an in vitro human gastric stem and/or progenitor cell model that may be used to study the mechanism of gastric carcinogenesis induced by helicobacter pylori infection. | 2007 | 17645461 |
| microbial genomes to write our history. | 2007 | 17624832 | |
| fluorescence diagnostics of helicobacter pylori-infected human gastric mucosa: establishing technique and validity. | bacterial factors, including strain type, anatomic distribution and density, and host responses are important determinants in the pathogenesis of erosive and neoplastic changes linked to gastric helicobacter pylori (h. pylori) infection. the purpose of this study was to investigate the potential use of photodiagnostics in mapping h. pylori infection. the relationship between fluorescence in individual gastric pits of h. pylori(+) and h. pylori(-) subjects versus that in larger field views of the ... | 2007 | 17613923 |
| [antibiotic resistance of helicobacter pylori]. | to examine the infection and bacteria resistance of helicobacter pylori (h.pylori) to clarithromycin and furazolidone,to determine whether the antibiotic resistance is primary or secondary, and to decide if a new h.pylori infection plays a role in eradication failures. | 2007 | 17611323 |
| prognostic significance of maspin expression in human gastric adenocarcinoma. | maspin is a member of the serpin family of protease inhibitors known to have tumor suppressor activity. however, molecular aspects in carcinogenesis and progression of gastric cancer remain largely unclear. previously we reported for the first time that maspin is induced in the course of gastric carcinogenesis. in the present study we evaluated maspin induction in gastric adenocarcinoma in relation to a number of clinicopathologic feature. | 2007 | 17591106 |
| the language used by helicobacter pylori to regulate human cells. | 2007 | 17538876 | |
| clinical impact of genetic aberrations in gastric malt lymphoma: a comprehensive analysis using interphase fluorescence in situ hybridisation. | there is a need for genetic biomarkers to guide prognosis and management of gastric mucosa-associated lymphoid tissue (malt) lymphomas. we assessed the incidence and clinical significance of the malt lymphoma-associated genetic abnormalities t(11;18)/api2-malt1, t(1;14)/bcl10-igh, t(14;18)/igh-malt1, t(3;14)/foxp1-igh, and extra copies of malt1 and foxp1 in gastric malt lymphomas from japan. | 2007 | 17525089 |
| re-expression of sonic hedgehog and reduction of cdx2 after helicobacter pylori eradication prior to incomplete intestinal metaplasia. | loss of sonic hedgehog (shh) and aberrant cdx2 expression are early changes correlating with the presence of intestinal metaplasia that occur in the gastric mucosa prior to neoplastic transformation. the aim of this study was to compare the improvement in corpus gastritis with shh and cdx2 expression after h. pylori eradication between subjects at high risk for gastric cancer and controls. the usefulness of serum pepsinogen levels as a predictor of resolved corpus gastritis was also examined. se ... | 2007 | 17520681 |
| effects of vaccination by a recombinant antigen ureb138 (a segment of the beta-subunit of urease) against helicobacter pylori infection. | helicobacter pylori has to counteract acidity during colonization in the stomach. the most important region for the enzymic activity of h. pylori urease, consisting of 138 aa (ureb138), was determined by a comparison of the homology of amino acid sequences, and a structural analysis, between urease of h. pylori and various other species. this region was expressed in escherichia coli as a fusion protein with glutathione s-transferase (gst), which was cleaved by prescission protease between the gs ... | 2007 | 17510273 |
| helicobacter pylori caga targets par1/mark kinase to disrupt epithelial cell polarity. | helicobacter pylori caga-positive strains are associated with gastritis, ulcerations and gastric adenocarcinoma. caga is delivered into gastric epithelial cells and, on tyrosine phosphorylation, specifically binds and activates the shp2 oncoprotein, thereby inducing the formation of an elongated cell shape known as the 'hummingbird' phenotype. in polarized epithelial cells, caga also disrupts the tight junction and causes loss of apical-basolateral polarity. we show here that h. pylori caga spec ... | 2007 | 17507984 |
| a proteomic approach for the identification of bismuth-binding proteins in helicobacter pylori. | helicobacter pylori is a major human pathogen that can cause peptic ulcers and chronic gastritis. bismuth-based triple or quadruple therapies are commonly recommended for the treatment of h. pylori infections. however, the molecular mechanisms underlying treatment with bismuth are currently not fully understood. we have conducted a detailed comparative proteomic analysis of h. pylori cells both before and after treatment with colloidal bismuth subcitrate (cbs). eight proteins were found to be si ... | 2007 | 17503094 |
| enhanced activation of cyclooxygenase-2 downregulates th1 signaling pathway in helicobacter pylori-infected human gastric mucosa. | evidence suggests that an impaired t-cell response against helicobacter pylori plays a role in the pathogenesis of h. pylori-related diseases. cyclooxygenase (cox) 2 has been shown to inhibit the production of t-helper (th) 1 cytokines. this study aimed to ascertain whether cox-2 downregulates th1 signaling pathway in human gastric mucosa colonized by h. pylori. | 2007 | 17492998 |
| a search engine to identify pathway genes from expression data on multiple organisms. | the completion of several genome projects showed that most genes have not yet been characterized, especially in multicellular organisms. although most genes have unknown functions, a large collection of data is available describing their transcriptional activities under many different experimental conditions. in many cases, the coregulatation of a set of genes across a set of conditions can be used to infer roles for genes of unknown function. | 2007 | 17477880 |
| flavodoxin:quinone reductase (fqrb): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to nadph production in helicobacter pylori and campylobacter jejuni. | pyruvate-dependent reduction of nadp has been demonstrated in cell extracts of the human gastric pathogen helicobacter pylori. however, nadp is not a substrate of purified pyruvate:ferredoxin oxidoreductase (pfor), suggesting that other redox active enzymes mediate this reaction. here we show that fqrb (hp1164), which is essential and highly conserved among the epsilonproteobacteria, exhibits nadph oxidoreductase activity. fqrb was purified by nickel interaction chromatography following overexpr ... | 2007 | 17468253 |
| assessment of the toll-like receptor 4 asp299gly, thr399ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer. | the intensity of the inflammation induced by helicobacter pylori colonization is associated with the development of distal gastric cancer (gc). the host response to h. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.our aim was to investigate whether the presence of the tlr4 asp299gly, tlr4 thr399ile and il-8-251 a/t polymorphisms had any influence in the development of distal gc in a mexican population. | 2007 | 17462092 |
| natural mannose-binding lectin (mbl) down-regulates phagocytosis of helicobacter pylori. | considering the role of lectin-carbohydrate interactions between helicobacter pylori bacteria and the host cells we addressed the question on how mannose binding lectin - mbl, present in human plasma, may influence the phagocytosis of h. pylori by peripheral blood granulocytes. for phagocytosis assay the granulocytes separated from peripheral blood of healthy h. pylori-seronegative donors were used. phagocytosis was estimated by fluorescence assay using fitc-labelled h. pylori cells. the mbl lev ... | 2006 | 17419286 |
| altered gastric corpus expression of tissue inhibitors of metalloproteinases in human and murine helicobacter infection. | matrix metalloproteinases (mmps) have roles in inflammation and other processes relevant to the architectural disturbances seen in the gastric mucosa in response to helicobacter pylori infection. upregulation of mmps has been reported in h pylori infection, but there are no detailed reports regarding altered production of their inhibitors, the tissue inhibitors of metalloproteinases (timps). | 2008 | 17412866 |
| interaction between the helicobacter pylori caga and alpha-pix in gastric epithelial ags cells. | the gastric pathogen helicobacter pylori (h. pylori) translocates the caga protein into epithelial cells by a type iv secretion process. upon translocation into the host cell cytosol, caga undergoes tyrosine phosphorylation. phosphorylation of caga occurs within the c terminus of the protein and is mediated by members of the src family of tyrosine kinases. phosphorylation of caga induces the dephosphorylation of as yet unidentified cellular proteins, rearrangements of the host cell actin cytoske ... | 2007 | 17405911 |
| analysis of the survival of h. pylori within a laboratory-based aquatic model system using molecular and classical techniques. | despite the significance of helicobacter pylori infection for man, its transmission is not clearly known. the human stomach is considered the reservoir of this pathogen, and one of the accepted routes is fecal-oral, in which water acts as a vector. however, although h. pylori epidemiology associates its transmission with water, only molecular and not cultural analysis detects the bacteria in water. this study was carried out to understand these data through studying the survival of h. pylori in ... | 2007 | 17401696 |
| epidemiology and pathophysiology of helicobacter pylori infection in children. | helicobacter pylori is one of the commonest bacterial pathogens in human. the organism is associated with development of peptic ulcer diseases, lymphoproliferative disorders and gastric cancer. residence in a developing country, poor socio-economic conditions and genetic predisposition are regarded as risk factors. prevalence of infection is higher in developing countries and re-infection is higher among under five children. it is transmitted mainly through feco-oral route in developing countrie ... | 2007 | 17401270 |
| human gastric glycosphingolipids recognized by helicobacter pylori vacuolating cytotoxin vaca. | many bacterial toxins utilize cell surface glycoconjugate receptors for attachment to target cells. in the present study the potential carbohydrate binding of helicobacter pylori vacuolating cytotoxin vaca was investigated by binding to human gastric glycosphingolipids on thin-layer chromatograms. thereby a distinct binding of the toxin to two compounds in the non-acid glycosphingolipid fraction was detected. the vaca-binding glycosphingolipids were isolated and characterized by mass spectrometr ... | 2007 | 17400502 |
| interaction of muc1 with beta-catenin modulates the wnt target gene cyclind1 in h. pylori-induced gastric cancer. | beta-catenin can function as an oncogene when it is translocated to the nucleus, binds to t-cell factor (tcf) or lymphoid enhance factor and transactivate its target gene. the mechanism responsible for the activation of wnt signaling pathway in the cytotoxin-associated antigen a (caga) helicobacter pylori (h. pylori)-infected gastric carcinoma has not been elucidated. we hypothesize that whether interaction of muc1 with beta-catenin modulates the wnt signaling and its target gene cyclind1 in cag ... | 2007 | 17393422 |
| helicobacter pylori-negative low-grade extranodal b-cell primary gastric mucosa-associated lymphoid tissue lymphoma. | helicobacter pylori-negative primary mucosa-associated lymphoid tissue (malt) lymphoma of the stomach--a primary gastric lymphoma (pgl)--is not very common. herein, we report a 77-year-old man with the chief complaint of intermittent epigastric pain. initial upper gastrointestinal (ugi) endoscopy showed multiple irregular ulcers (gus) over the antrum with poor distention of the stomach, and gastric adenocarcinoma (borrmann type iv, linitis plastica) was suspected. but the biopsy specimens of the ... | 2007 | 17389157 |
| no association between helicobacter pylori seropositivity and ornithine decarboxylase (odc) a317g polymorphism, and no modification by nad(p)h:qinone oxidoreductase 1 (nqo1) c609t. | our previous epidemiologic study reported that nad(p)h:quinone oxidoreductase 1 (nqo1) 609c/c with full enzyme activity was a high risk genotype for helicobacter pylori (h. pylori) seropositivity. since nqo1 stabilizes ornithine decarboxylase (odc), which attenuates the innate immune response through elevated polyamines, odc functional polymorphisms may also influence h. pylori seropositivity. this study aimed to examine the association with odc a317g polymorphism, as well as the modification by ... | 2007 | 17378176 |
| construction of recombinant attenuated salmonella typhimurium dna vaccine expressing h pylori ureb and il-2. | to construct a recombinant live attenuated salmonella typhimurium dna vaccine encoding h pylori ureb gene and mouse il-2 gene and to detect its immunogenicity in vitro and in vivo. | 2007 | 17352028 |
| celecoxib inhibits cdx2 expression and prevents gastric cancer in helicobacter pylori-infected mongolian gerbils. | the aim of this study was to see whether administration of celecoxib, a selective cox-2 inhibitor, prior to the appearance of intestinal metaplasia could prevent the development of gastric cancer in helicobacter pylori-infected mongolian gerbils. | 2007 | 17341852 |
| antisense rna modulation of alkyl hydroperoxide reductase levels in helicobacter pylori correlates with organic peroxide toxicity but not infectivity. | much of the gene content of the human gastric pathogen helicobacter pylori ( approximately 1.7-mb genome) is considered essential. this view is based on the completeness of metabolic pathways, infrequency of nutritional auxotrophies, and paucity of pathway redundancies typically found in bacteria with larger genomes. thus, genetic analysis of gene function is often hampered by lethality. in the absence of controllable promoters, often used to titrate gene function, we investigated the feasibilit ... | 2007 | 17337572 |
| helicobacter pylori stimulates urokinase plasminogen activator receptor expression and cell invasiveness through reactive oxygen species and nf-kappab signaling in human gastric carcinoma cells. | the gastric pathogen, helicobacter pylori (h. pylori), has been associated with the progression of gastric cancer. it was previously reported that h. pylori induced urokinase plasminogen activator receptor (upar) expression and stimulated cell invasiveness in human gastric cancer ags cells. however, the precise mechanisms for how h. pylori upregulates upar are unclear. this study investigated the underlying signal pathways in h. pylori-induced upar in human gastric cancer ags cells. the intracel ... | 2007 | 17334646 |
| synergistic antidigestion effect of lactobacillus rhamnosus and bovine colostrums in simulated gastrointestinal tract (in vitro). | probiotics and bovine colostrums had been proven to be beneficial for human health. lactobacillus rhamnosus zdy114 and anti-helicobacter pylori bovine colostrums were used for the preparation of microecological additives, and their synergistic antidigestion effect in the simulated gastrointestinal tract (in vitro) was investigated. either l. rhamnosus or purified igg from immune colostrums was very sensitive in simulated gastric environment and slightly sensitive in simulated intestinal tract. n ... | 2007 | 17318540 |
| [gastric relapse of stage i ocular adnexal mucosa-associated lymphoid tissue lymphoma]. | a 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (malt lymphoma) was successfully treated with local radiation therapy. the gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. eradication therapy against helicobacter pylori was successfully done, however, the patient developed gastric malt lymphoma two years after the initial treatment. southern blot analysis of the immunoglobulin heavy ... | 2007 | 17313077 |
| allergic sensitization and microbial load--a comparison between finland and russian karelia. | epidemiological data have indicated that some infections are associated with a low risk of allergic diseases, thus supporting the idea (hygiene hypothesis) that the microbial load is an important environmental factor conferring protection against the development of allergies. we set out to test the hygiene hypothesis in a unique epidemiological setting in two socio-economically and culturally markedly different, although genetically related, populations living in geographically adjacent areas. t ... | 2007 | 17302731 |
| cytochrome p450 2c19 polymorphism influences the preventive effect of lansoprazole on the recurrence of erosive reflux esophagitis. | the efficacy of lansoprazole (lpz) at inhibiting gastric acid secretion is influenced by cytochrome p450 2c19 (cyp2c19) polymorphism. the purpose of the present study was to investigate whether cyp2c19 polymorphism had an influence on the remission of erosive reflux esophagitis (re) during maintenance therapy with lpz. | 2007 | 17295875 |