Publications

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evidence against transmission of scrapie by animal house fomites. 19705463062
simple method of evaluating scrapie in mice.mice in advanced scrapie characteristically clasp their hindlegs together. as the disease progresses into the clasping stage, mice exhibit a sequence of identifiable hindleg reactions which have categorized and assigned relative scores permitting objective, quantitative evaluation of disease.19705466135
the incorporation of (3h) thymidine and (14c) glucosamine into a dna-polysaccharide complex in normal and scrapie-affected mouse brain. 19705466138
the unsuccessful dialysis of scrapie agent from goat brain and spleen. 19705498566
multiplication of scrapie agent in cell culture. 19705498935
growing points in cell pathology. ultrastructural aspects. 19705529268
agriculture and the public health. the milroy lectures, 1970. 19705535790
pathogenesis of scrapie in the mouse: the role of the spleen. 19704985820
animal model in biomedical research. 19704993935
investigations on mouse-adapted scrapie virus. 19704394673
amyloidosis, alzheimer's disease, and ageing. 19704196010
effects of antilymphocytic serum on host responses to infectious agents. 19704312737
an experimental examination of the scrapie agent in cell membrane mixtures. ii. the association of scrapie activity with membrane fractions. 19714326373
enzymes in scrapie-affected mouse spleen. 19714252237
[ataxia associated with infections and toxicosis]. 19714402516
experimental transmission of scrapie to voles and chinese hamsters. 19714099889
early reduction of drinking in mice with scrapie. 19714100232
histopathological similarities between scrapie and cuprizone toxicity in mice. 19714101034
drinking behaviour in scrapie. 19714101464
susceptibility of mink to sheep scrapie.a progressive, fatal spongiform polioencephalopathy was induced in mink intracerebrally inoculated with a suspension of brain from a suffolk sheep with naturally acquired scrapie. the clinical signs and pathological lesions of the experimental disease were indistinguishable from transmissible mink encephalopathy, a disease of undetermined origin that occurs in mink.19714102123
slow infections of the central nervous system. i. 19714102745
slow infections of the central nervous system. ii. 19714105437
visna virus: a slow virus with an rna dependent dna polymerase. 19714994257
viral properties of scrapie. 19714994813
vacuolation of neurons in natural scrapie. electron microscopic observations. 19715542499
viruses and autoimmune diseases in animals other than man. 19714937605
scrapie in immunologically deficient mice. 19714940428
chronic viral infections of the central nervous system. 19714940819
altered plasma membranes in experimental scrapie. 19714942441
accumulation of neurophysin in the median eminence and the cerebellum of sheep with natural scrapie. 19714945728
slow viral infections of the nervous system and genetic disease.slow viral infections are characterized by a long incubation period, protracted clinical course, and limited host range. scrapie of sheep and kuru and creutzfeldt-jakob disease of man are slow infections which have been regarded at one time or another as being of genetic etiology. the initial assumption that these represented hereodofamilial degenerative diseases came from their occurrence in families or in population aggregates, their chronic afebrile clinical courses and their histopathologic ...19714950946
[slow-virus encephalopathies and their animal models]. 19714951067
dna polymerase activities in varions of visna virus, a causative agent of a "slow" neurological disease.the presence is reported of an rna-instructed dna polymerase in visna virus, the causative agent of a "slow" neurological disease in sheep. the product synthesized by the rna-directed reaction has been shown to be a dna heteropolymer by the following criteria: synthesis requires the presence of all four deoxyriboside triphosphates; the product is resistant to ribonuclease and alkali but is degraded by dnase; and the product has a density of 1.420 in cs(2)so(4) solution, characteristic of dna.vis ...19714993214
growth potential of scrapie mouse brain in vitro. 19714927201
transmissible degenerative diseases of the nervous system. 19714934247
intramammary inoculation of mice with scrapie. 19714995406
multiplication of scrapie agent in mouse spleen. 19714995426
detection of the scrapie agent in tissues of normal mice with special reference to the possibility of accidental laboratory contamination. 19714995824
an experimental examination of the scrapie agent in cell membrane mixtures. i. stability and physicochemical properties of the scrapie agent. 19714996972
growth characteristics of scrapie agent-infected mouse brain cell cultures. 19714997448
an experimental examination of the scrapie agent in cell membrane mixtures. 3. studies of the operational size. 19714998373
slow virus diseases of the central nervous system. 19714999325
[slow virus infection from the virological view]. 19714999433
transmission and characterization of the agents of spongiform virus encephalopathies: kuru, creutzfeldt-jakob disease, scrapie and mink encephalopathy. 19715000225
multiplication of the scrapie agent. 19715001939
enhanced survival of germfree mice after infection with irradiated scrapie brain. 19715002572
biochemical and histopathological changes in the brains of mice inoculated with scrapie by the intraperitoneal route. 19715002721
[slow infections of the central nervous system]. 19715002733
[slow virus infections of the central nervous system]. 19715002801
lack of effect of immunosuppression on scrapie infection in mice. 19715003362
[human and animal neuropathology and the slow and latent viruses]. 19715003725
status spongiosus of nervous tissue. electron microscopic studies. 19715004121
aggregations of 35-nanometer particles associated with neuronal cytopathic changes in natural scrapie.neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. membrane-bound accumulations of the 35-nm particles are fotnd in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. such particles are present only in a small number of vacuolated neurons.19715099604
[new observations on the occurrence of a rna-dependent dna-polymerase]. 19715102738
enzymatic changes in scrapie agent-infected mouse brain. 19715104930
clinical and histological observations on cuprizone toxicity and scrapie in mice. 19715105163
retinopathy in sheep affected with natural scrapie. 19715105164
an attempt to determine whether maternal transmission of scrapie occurs in mice. 19715106162
[serological reactions in scrapie in mice]. 19715107064
brain cell cultures from mice affected with scrapie or fed with cuprizone. 19715107104
host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. 19715165642
failure of adenine arabinoside to modify scrapie in mice. 19715168245
veterinary research. 19725024511
slow virus infections. 19725040011
metabolism of polyamines in normal and scrapie-affected mouse brain and spleen. 19725062242
[slow-virus infections of the central nervous system]. 19725062583
[slow virus infections]. 19725063782
inoculation of voles, chinese hamsters, gerbils and guinea-pigs with scrapie brain material. 19725065061
studies on dna from normal and scrapie-affected mouse brain. 19725065429
scrapie agent and neurones. 19724629216
[slow viruses in neurologic diseases]. 19724628425
scrapie. 19724110651
scrapie in young mice. 19724110680
scrapie: an inefective peptide? 19724111222
scrapie-induced changes in the percentage of polymorphonuclear neutrophils in mouse peripheral blood.a decrease in the percentage of polymorphonuclear neutrophils (pmn) in the peripheral blood of mice appeared 3 days after intracerebral (ic) inoculation with scrapie mouse brain homogenate. mice inoculated ic with normal mouse brain had pmn percentages similar to those found for uninoculated mice. this difference between normal and scrapie-inoculated mice continued throughout the preclinical phase of the disease. in the clinical phase of the disease, the percentage of pmn was either higher or lo ...19724118048
interspecies patterns of slow virus diseases. 19724577378
is the scrapie agent a viroid? 19724622215
scrapie: a prototype slow infection. 19724622954
transmission of scrapie to the cynomolgus monkey (macaca fascicularis). 19724623139
absence of eclipse phase in scrapie mice. 19724623142
competition between different scrapie agents in mice. 19724624846
spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep. 19724625088
subacute spongiform virus encephalopathies. scrapie, kuru and creutzfeldt-jakob disease: a review. 19724626566
scrapie: effect of dh gene on incubation period of extraneurally injected agent. 19724627371
the scrapie agent: a small deoxyribonucleic acid-mediated virus? 19724627686
interferon system in mice infected with the scrapie agent.therapy with polyinosinic-polycytidylic acid did not protect scrapie-infected mice; scrapie infection did not affect the interferon response to polyinosinic . polycytidyl acid or newcastle disease virus.19724628902
isolation from mouse spleen of cell populations with high specific infectivity for scrapie virus.spleen cells from mice infected with scrapie virus were separated into subpopulations on the basis of buoyant density in discontinuous gradients of isotonic albumin or differential adherence of cells to plastic. at three different intervals after infection, a population of "less dense" cells was found in albumin gradients that had 40-to 60-fold higher specific infectivity (cells per median lethal dose) than the total cell suspension before gradient sedimentation. the class of cells associated wi ...19724629076
large fraction of scrapie virus resistant to lipid solvents. 19724629086
changes in drinking and feeding habits of mice with experimental scrapie. 19724630696
an electron-microscopic study of scrapie in the rat: further observations on "inclusion bodies" and virus-like particles. 19724631789
results and discussion. i. polyacrylamide gel electrophoresis of sds extracts of mouse brain subcellular fractions. 19724632952
[slow viruses and the nervous system]. 19724673392
glycoprotein biosynthesis and scrapie. 19724674120
the nature of the increased rate of dna synthesis in scrapie-affected mouse brain. 19724675812
electron microscopic studies of the brain of sheep with natural scrapie. i. the fine structure of neuronal vacuolation. 19724676242
electron microscopic studies of the brain of sheep with natural scrapie. ii. the small nerve processes in neuronal degeneration. 19724676275
[histopathological changes in the brain of sheep affected with scrapie (author's transl)]. 19724680461
transmissible mink encephalopathy: pathogenesis and nature of the aetiological agent. 19724281785
spongiform virus encephalopathies. 19724281787
demyelinating diseases and certain virus infections. 19724359244
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