Publications

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[slow viruses and the nervous system]. 19724673392
spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep. 19724625088
glycoprotein biosynthesis and scrapie. 19724674120
the nature of the increased rate of dna synthesis in scrapie-affected mouse brain. 19724675812
changes in drinking and feeding habits of mice with experimental scrapie. 19724630696
an electron-microscopic study of scrapie in the rat: further observations on "inclusion bodies" and virus-like particles. 19724631789
[slow viruses in neurologic diseases]. 19724628425
competition between different scrapie agents in mice. 19724624846
scrapie: effect of dh gene on incubation period of extraneurally injected agent. 19724627371
the scrapie agent: a small deoxyribonucleic acid-mediated virus? 19724627686
demyelinating diseases and certain virus infections. 19724359244
[creutzfeldt-jakob disease and its transmission]. 19724567162
electron microscopic studies of the brain of sheep with natural scrapie. i. the fine structure of neuronal vacuolation. 19724676242
interspecies patterns of slow virus diseases. 19724577378
implications of slow viral diseases of domestic animals for human disease. 19734578994
[slow viruses and cns. ii]. 19734582184
glycosidases in normal and scrapie mouse brain. 19734735407
rapid immunological method for diagnosis of natural scrapie in sheep. 19734583489
scrapie-like antigen(s) in ageing tissues. 19734583502
a new hypothalamic pathway to the median eminence containing neurophysin and its hypertrophy in sheep with natural scrapie. 19734571633
aberrant synaptic development. 19734573665
developmental maturation of susceptibility to scrapie in mice. 19734632780
[slow viruses and the central nervous system. i]. 19734579465
glycoprotein biosynthesis in normal and scrapie-affected mouse brain. 19734796893
similarities between the scrapie agent and the agent of the potato spindle tuber disease. 19734209370
viral and non-viral properties of the scrapie agent. 19734209651
[viral infections and chronic central nervous system diseases]. 19734347158
experimental subacute spongiform virus encephalopathies in primates and other laboratory animals.the host range of subacute spongiform virus encephalopathies is described. the asymptomatic incubation period and the duration of the illnesses in various species of animal hosts is discussed along with information on additional species of old world and new world monkeys and the domestic cat, which have been shown to be susceptible to subacute spongiform virus encephalopathies.19734199733
the distribution of vasopressin and neurophysin in the hypothalamo-distal-neurohypophysial and hypothalamo-infundibular neurosecretory systems of normal and scrapie-affected sheep. 19734573917
comparative studies on visna, progressive pneumonia, and rous sarcoma viruses by electron microscopy. 19734349766
viral infections and demyelinating diseases. 19734348989
argyrophilic plaques in mice inoculated with scrapie from particular sources. 19734120692
inhibition of rna slow viruses by thiosemicarbazones. 19734122206
immunological reactions in scrapie: the basis of a rapid titration method. 19734204065
[creutzfeldt-jakob's disease. a human spongiform viral encephalopathy]. 19734196163
[disseminated sclerosis and slow virus diseases (author's transl)]. 19734127809
emergence of new antigens in ageing tissues. 19734129994
altered response to scrapie tissues in neurological disease. possible evidence for an antigen associated with reactive astrocytes. 19734200639
[latest achievements in the study of subacute spongious encephalopathies]. 19734204259
failure to demonstrate a humoral immune response to scrapie infection in mice. 19734200779
scrapie in mice. agent-strain differences in the distribution and intensity of grey matter vacuolation. 19734199908
differences in access into the central nervous system of me7 scrapie agent from two strains of mice. 19734199906
scrapie in mice. some effects on the brain lesion profile of me7 agent due to genotype of donor, route of injection and genotype of recipient. 19734199907
virus-like particles in natural scrapie of the sheep. 19734196559
animal health. 19734148822
transmissible mink encephalopathy: studies on the peripheral lymphocyte.circulating lymphocytes from mink with transmissible mink encephalopathy were studied for the presence of virus particles and for infectivity. electron microscope examination of phytohemagglutinin-stimulated lymphocyte cultures revealed no evidence of virus-like particles. circulating lymphocytes were also found to be noninfectious when the transmissible agent could be demonstrated in intact lymphoid organs in infected mink. a lymphopenia was detected in affected mink during the late clinical st ...19734197388
multiplicity of scrapie virus in infected mouse spleen cells in vivo.subpopulations of spleen cells from scrapie virus-infected mice were used to determine the average virus content of infected cells in vivo at a time when virus was rapidly increasing in titer in lymphoreticular tissues. comparison of the mean lethal doses of lysed to intact cells indicated averages of 2 to 6 infectious units per infected cell. in another experiment, preparations of cytoplasmic nucleic acids extracted from spleen cells of infected mice had no detectable infectivity, which suggest ...19734197750
ultrastructural observations on scrapie in the gerbil. 19734209188
higher frequency of a protein band in the cerebrospinal fluid from scrapie mice. 19734141787
a cytological study of the karyotype of spleen cells from scrapie-affected chinese hamsters. 19734738622
a report of scrapie in sheep in kenya. 19734731572
an attempt to induce scrapie in local sheep in bulgaria. 19734779441
unsuccessful attempts to produce disease with tissues from mice fed on a diet containing cuprizone. 19734736048
clinical and histological recovery from the scrapie-like spongiform encephalopathy produced in mice by feeding them with cuprizone. 19734737068
replication of the factor in scrapie material that causes a decrease in polymorphonuclear neutrophils. 19734737373
permeability of blood vessels in mice affected with scrapie or fed with cuprizone. 19734797843
thymectomy and immunological ageing in mice: precocious emergence of scrapie-like antigen. 19734798070
a comparison of the biochemical changes induced in mouse brain cuprizone toxicity and by scrapie infection. 19744859191
naturally-occurring scrapie in goats. 19744859427
the turnover of isotopically labelled dna in vivo in developing, adult and scrapie-affected mouse brain. 19744859554
slow virus diseases of the central nervous system. 19744213582
scrapie. 19744214256
slow virus diseases. 19744372938
slow infections of the nervous system and the subacute spongiform encephalopathies. 19744374882
maternal and lateral transmission of scrapie in sheep. 19744212154
course of experimental scrapie virus infection in the goat. 19744207308
a rapid immunologic test for scrapie in sheep. 19744132111
editorial: kuru, creutzfeldt-jakob, and scrapie. 19744140986
an electron microscopic study of the scrapie mouse and rat: further observations on virus-like particles with ruthenium red and lanthanum nitrate as a possible trace and negative stain. 19744141754
depression of polymorph counts by various scrapie agents. 19744207411
scrapie and transmissible mink encephalopathy: search for infectious nucleic acid.brain preparations from animals with scrapie or transmissible mink encephalopathy were phenol extracted and examined for the presence of pathogenic nucleic acid. animals inoculated with various extracts remained healthy, and analysis on 2.6 to 5% polyacrylamide gels failed to detect a difference in extractable rna species between infected and normal mink brain.19744207527
ruthenium red and lanthanum nitrate a possible tracer and negative stain for scrapie "particles"? 19744140674
glycosyl transferase activity in normal and scrapie-affected mouse brain. 19744212037
letter: scrapie. 19744213860
pathology of choroid plexus in spontaneous immune complex disease and chronic viral infections. 19744276256
reduced susceptibility to scrapie in mice after steroid administration. 19744209742
ultrastructural studies of spleens, brains, and brain cell cultures of mice with scrapie. 19744215206
comparative scrapie activity of brain material and cerebrospinal fluid from scrapie-affected rats. 19744210058
scrapie in sheep selectively bred for high susceptibility. 19744824026
scrapie: observations on a field outbreak. 19744836096
[visna virus-like particles in cultures of choroid plexus cells of a goat with symptoms of visna infection]. 19744363195
nature of the scrapie agent: evidence against a viroid.the postulated viroid nature of scrapie agent was tested. since the agent could not be recovered after a carefully controlled phenol extraction of infected mouse brains, it is suggested that this agent is not a viroid.19744372389
further observations on the production of scrapie in sheep by oral dosing with foetal membranes from scrapie-affected sheep. 19744425935
an electron microscopic study of natural scrapie sheep brain: further observations on virus-like particles and paramyxovirus-like tubules. 19744446935
no mouse pmn leukocyte depression after inoculation with brain tissue from multiple sclerosis or spongiform encephalopathies. 19744589575
recent data on the properties of the viruses of kuru and transmissible virus dementias. 1975134597
[discovery of viroids and possible relationship with human and veterinary medicine].the researches of diener and co-workers and those of the semancik's group, have recently established that some plant diseases, such as potato spindle tuber, citrus exocortis disease and chrysanthemum stunt, are caused by a new class of pathogens, named viroids. these are the smallest known agents (they are smaller than viruses) having a molecular weight of ca 10(5) daltons, and composed of a highly structured rna, rich in guanine-cytosine base pairs without a capsid. little is known about the or ...1975132907
newer knowledge in comparative virology--its contribution to human health research.like other comparative sciences, and despite its recent beginning comparative virology has already contributed useful applications and observations to human health research. teachings derived from the study of marek's disease found application in that of burkitt's lymphoma, and may lead to a possible vaccine against the human disease. equally useful information came from the study of canine distemper in the development of a chorio-allantoic membrane attenuated measles vaccine, and in our knowled ...1975167504
our present knowledge of the pathology of dementias. 1975172773
familial and sporadic chronic neurological degenerative disorders transmitted from man to primates. 1975125030
letter: interspecies transmission of scrapie-like diseases. 197554832
slow encephalopathies, inflammatory responses and arachis oil.there is much interest in the possibility that diets rich in some plant oils may be of prophylactic and curative value in certain clinical conditions. this is generally attributed to the immunosuppressive effects of polyunsaturated fatty acids. arachis (peanut) oil injections can increase the incubation period of experimental scrapie in mice. in the late 1950s several workers showed that arachis and some other oils contained very potent anti-inflammatory components quite apart from the polyunsat ...197547424
persistent or slow viral infections and related diseases.the discovery of persistent transmissible agents by veterinarians has led to striking advances in the infectious cause of neuropathies of human beings. there is evidence for persisting infection in congenital rubella and the herpes group of viruses including cytomegalovirus infections. hepatitis types a and b are candidates for inclusion in the category of persisting viral infections. the rubeola or measles virus is established as a persistent virus which causes elevated antibodies in the serum ...1975165638
the occurrence of vacuolated neurons in the brains of hamsters affected with subacute sclerosing encephalitis following measles or langat virus infection.hamsters infected by the intranasal route with either hamster adapted langat virus passaged at least 10 times in hamsters and the hnt strain of measles virus passaged 149 times in hamsters, developed subacute sclerotic lesions in the pyriform cortex, and beginning from 2 months after infection, were accompanied by neuronal vacuolation with ballooning of the cytoplasm, especially in parts of the brain in close proximity of the sclerotic lesions. the vacuolated neurons resembled those seen in scra ...1975173381
multiple sclerosis: relation to scrapie and slow infection; ageing and measles.multiple sclerosis (ms) is shown to have no relation to scrapie and the evidence for a "slow infective" aetiology is very meagre. it is not related to an ageing process during which scrapie-like antigens make their appearance as they do in young animal with the disease. the emergence of scrapie-like antigens in ageing tissues is discussed. the increased sensitization of ms lymphocytes to scrapie, as opposed to normal brain (or spleen), is not characteristic of the disease, but occurs in other co ...19751217459
transferrin polymorphism in herdwick sheep.the transferrin system in herdwick sheep, bred at compton, was investigated with special reference to the susceptibility of the flock to experimentally produced scrapie. no significant correlations were observed between susceptibility and transferrin phenotypes.19751217754
extraneural competition between different scrapie agents leading to loss of infectivity. 1975804143
the establishment of sheep flocks of predictable susceptibility to expirimental scrapie.a selection experiment, based on a foundation stock of over 700 herdwick sheep and aimed at producing divergent populations of predictable high susceptibility or resistance to experimental scrapie was begun at this institute in 1961. twelve years later, flocks of presumed 100 per cent susceptibility to the cheviot-dervied scrapie agent ssbp-1 used throughout the experiment, and also manifesting a high incidence of the disease when challenged with other scrapie strains, are used in the compton sc ...1975804177
immunochemical studies on the storage and axonal transport of neurophysins in the hypothalamo-neurohypophyseal system. 1975804289
host-pathogen interactions in scrapie.there are many strains of the agent which causes scrapie and these can be used singly or given as mixed infections to investigate the ways in which agent and host control mechanisms interact during the pathogenesis of the disease. two genes in mice are described; one only affects the kinetics of the disease when extraneural injections are used, the other acts irrespective of the route of injection and it is suggested that it determines the structure of a multimeric agent-replication site, the nu ...1975807505
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