| engraftment failure associated with peripheral blood stem cell transplantation after b19 parvovirus infection. | | 1996 | 8695875 |
| parvovirus b19 infection and diamond-blackfan anaemia. | it is the purpose of the study to report the frequency of parvovirus in children with a diagnosis of diamond-blackfan anaemia and to discuss the possible aetiological role of parvovirus in diamond-blackfan anaemia. we found parvovirus dna in 3 of 11 bone marrow smears. giant pronormoblasts showed low sensitivity (33%) and poor specificity (75%). the presence of giant pronormoblasts was associated with a very high myeloid:erythroid ratio, and may not be specific for parvovirus infection, but a fe ... | 1996 | 8695985 |
| parvovirus b19 infection in behçet's disease. | to investigate whether parvovirus b19 infection is associated with behçet's disease (bd). | 1996 | 8697661 |
| [usefulness of bone marrow examination in patients with advanced hiv infection]. | a bone marrow investigation is a common examination in hiv infected patients for the study of cytopenia, febrile syndromes of unknown origin and extension of neoplastic disorders. a study was made of bone marrow specimens from 35 patients with advanced hiv infection (stage ic or c, cdc, atlanta) for morphologic and culture investigations (aerobes, anaerobes, fungi, and mycobacteria). in nine patients cytopenia accounted for the investigation of bone marrow specimens (9 aspirates and 3 biopsies); ... | 1996 | 8701058 |
| [dermatologic symptoms of parvovirus b19 infections]. | infections with parvovirus b19 are often characterized by the well-known erythema infectiosum, usually accompanied by fever and arthralgia. furthermore the virus may cause a lethal hydrops fetalis during the pregnancy or a severe aplastic crisis in patients suffer from chronic hemolytic anemia. we present three patients infected by parvovirus b19. whose skin lesions included a non-specific exanthem, erythema multiforme, and purpura. the virus infection was confirmed both by serology and pcr iden ... | 1996 | 8707582 |
| new pathogens, and diseases old and new. i) afipia felis and rochalimaea. ii) parvovirus b 19. iii) herpesvirus 6. | the paper describes events that in the last fifteen years, have led to the identification of the aetiological agents of three widely known diseases: cat scratch disease, erythema infectiosum and exanthem subitum. the particular features of afipia felis and rochalimaea, parvovirus b 19 and herpesvirus 6 are presented. the paternity of new diseases (i.e. bacillary angiomatosis, bacillary peliosis hepatitis, les-like syndrome, chronic fatigue syndrome, petechial glove and sock syndrome, etc.) has a ... | 1995 | 8710408 |
| [description of 31 pediatric cases of infection caused by human parvovirus b 19]. | fundamentals: [corrected] human parvovirus b19 has been identified as the etiological agent implicated in several clinical forms of disease. the aim of this study was to define the clinical aspects observed in the children with human parvovirus infection in our hospital. | 1996 | 8714183 |
| [intrafamily infection caused by parvovirus b19: different manifestations according to age]. | | 1996 | 8714197 |
| infection-associated hemophagocytic syndrome complicated by infectious lymphoproliferation: a case report. | the case of a 7-year-old boy with virus-associated hemophagocytic syndrome (vahs) and serologically proven parvovirus b-19 infection is described. the patient with vahs presented with fever, hepatosplenomegaly, pancytopenia, and hyperlipidemia type iv. after induction therapy with vp-16 and prednisone, partial remission was achieved. despite maintenance therapy, reinductions, and the addition of cyclosporine a for 3 months, several relapses occurred. the therapy was stopped because of life-threa ... | 1996 | 8721028 |
| transient aplastic crisis in a leukemic child caused by parvovirus b19 infection. | acute parvovirus b19 infection was confirmed in an 8-year-old girl with acute lymphoblastic leukemia on maintenance therapy by electron microscopy, dna, and serological techniques. clinical manifestations were typical of severe anemia, fever, leukopenia, and thrombocytopenia. increased levels of serum erythropoietin were detected in the course of the infection. the patient's recovery was supported by corticosteroids, red blood cell transfusions, g-csf, and commercial immunoglobulin preparations. | 1996 | 8721033 |
| a case of severe thrombocytopenia due to parvovirus b19 virus. | a 9-year-old girl admitted with generalized skin, mucosa, and genitourinary system bleeding had anemia and thrombocytopenia. her bone marrow was normocellular. parvovirus b19 igm and igg were positive. an absence of reticulocytopenia suggested that the virus affected only the megakaryocytic cell line and the anemia was due to generalized bleeding resulting from thrombocytopenia. intravenous immunoglobulin treatment was instituted. on the tenth day of hospitalization the patient recovered from an ... | 1996 | 8721035 |
| detection of parvovirus b19 dna in bone marrow cells by chemiluminescence in situ hybridization. | a chemiluminescence in situ hybridization method was developed for the search of b19 parvovirus dna in bone marrow cells, employing digoxigenin-labeled b19 dna probes, immunoenzymatically detected with a highly sensitive 1,2-dioxetane phosphate as chemiluminescent substrate. the light emitted from the in situ-hybridized probe was analyzed and measured by a high-performance luminograph connected to an optical microscope and to a personal computer for the quantification of the photon fluxes from t ... | 1996 | 8727929 |
| [parvovirus b19 infection. new physiopathological approaches]. | knowledge of the pathophysiological mechanisms governing parvovirus b19 infection has been modified with the recent discovery of its cellular receptor. the cell lines susceptible to infection can be identified on the basis of the nature and distribution of the virus in the human organism. the parvovirus b19 can undergo two types of cycles within the host cell. the first is a complete cycle within the infected cell leading to cell death by lysis. in the second, the cycle aborts and cell death is ... | 1996 | 8728903 |
| parvovirus b19 and hemodialysis. | | 1996 | 8730455 |
| fetal hydrops secondary to human parvovirus infection in early pregnancy. | parvovirus b19 infection has been associated with fetal anaemia, hydrops, and in some cases demise. most of the reported cases of fetal hydrops were detected in second-trimester fetuses. we report a series of three cases in which human parvovirus infection was associated with hydropic changes at an earlier gestational age. spontaneous resolution of hydrops occurred in all fetuses. a greater understanding of the natural history of human parvovirus infection is needed prior to deciding on the mode ... | 1996 | 8734809 |
| human parvovirus b19 infection and hydrops fetalis in rio de janeiro, brazil. | formalin-fixed paraffin embedded lung and liver tissue from 23 cases of non immune hydrops fetalis and five control cases, in which hydrops were due to syphilis (3) and genetic causes (2), were examined for the presence of human parvovirus b19 by dna hybridisation. using in situ hybridisation with a biotynilated probe one positive case was detected. using 32p-labelled probes in a dot blot assay format, five further positives were obtained. these were all confirmed as positive by a nested polymer ... | 1996 | 8736082 |
| fetal parvovirus b19 infection and liver disease of antenatal onset in an infant with ebstein's anomaly. | fetal parvovirus b19 infection has been reported in association with hydrops and fetal demise, myocarditis, and congenital anomalies, as well as with normal outcome of pregnancy. one infant with liver disease of fetal onset associated with parvovirus b19 infection has been described. we have seen another such infant, in whom marked siderosis of the liver suggested accelerated destruction of erythrocytes and portal tract fibrosis with proliferation of bile ducts suggested intrauterine infection. ... | 1995 | 8736602 |
| polyarteritis nodosa and hiv infection: no evidence of a direct pathogenic role of hiv. | a case of polyarteritis nodosa identified by the american college of rheumatology (acr) 1990 criteria in a 44-year-old hiv-infected man is described. the search for cytomegalovirus, hbv and b19 parvovirus infections was negative. in situ hybridization did not reveal proviral hiv-1 dna in a skin sample. a zidovudine-associated vasculitis was excluded. corticosteroid therapy resolved vasculitis manifestations and was well tolerated without opportunistic infections during the 10-month follow-up per ... | 1996 | 8740112 |
| leukophagocytosis in human parvovirus b19-induced transient bicytopenia in a healthy child. | a previously health 11 year old boy had transient leukopenia and thrombocytopenia associated with human parvovirus b19 (b19) infection. this case suggested that low-grade hemophagocytosis can be involved in developing b19-related cytopenia even in an otherwise healthy child. bone marrow aspiration at an early stage could reveal the underlying mechanism of b19-related cytopenia. | 1996 | 8741323 |
| [severe parvovirus b19 infection in an immunocompetent child with hemophilia a]. | b19 parvovirus is a widespread virus whose typical manifestations in immunocompetent children are erythema infectiosum, acute erythroblastopenia and fetal anemia. | 1996 | 8745824 |
| diagnosis of parvovirus b19 infection by detection of specific immunoglobulin m antibody in saliva. | serum and saliva samples were simultaneously collected from patients with b19 infection. specimens were collected in a period of 1 to 18 days after the onset of symptoms. saliva samples were collected with a commercial device, orasure. the quality of these samples was evaluated by determining the concentration of total immunoglobulin g (igg) by an enzyme immunoassay. the concentration of igg in these samples ranged from 4.8 to > 250 mg/liter. b19 infection was confirmed for 20 patients by testin ... | 1996 | 8748306 |
| spectrum of parvovirus b19 infection: analysis of an outbreak of 43 cases in cadiz, spain. | in the spring of 1993, an epidemic of infection with human parvovirus b19 occurred in cadiz, spain. evaluation of the 43 patients in whom this diagnosis was confirmed revealed four groups of predominant manifestations: (1) hematologic manifestations in six cases (13.9%), including four of aplastic crisis and two of pancytopenia; (2) dermatologic manifestations in 23 cases (53.4%), including 10 of erythema infectiosum and one of erythema multiforme ampullosum; (3) arthralgias/arthritis in nine ca ... | 1995 | 8749627 |
| prevalence and clinical significance of anticardiolipin antibodies in pregnancies complicated by parvovirus b19 infection. | anticardiolipin antibodies were measured in 60 pregnant women with acute parvovirus b19 infection. test results for eight (13.3 per cent) women were positive for anticardiolipin antibody. six of these eight women became negative later, yielding a prevalence of anticardiolipin antibodies of 3.3 per cent (2/60) 6 months after acute parvovirus b19 infection. anticardiolipin antibody positivity was not associated with an increased risk of abortion, fetal death, or maternal complications. this study ... | 1995 | 8750289 |
| cryo-electron microscopy studies of empty capsids of human parvovirus b19 complexed with its cellular receptor. | the three-dimensional structures of human parvovirus b19 vp2 capsids, alone and complexed with its cellular receptor, globoside, have been determined to 26 resolution. the b19 capsid structure, reconstructed from cryo-electron micrographs of vitrified specimens, has depressions on the icosahedral 2-fold and 3-fold axes, as well as a canyon-like region around the 5-fold axes. similar results had previously been found in an 8 angstrom resolution map derived from x-ray diffraction data. other parvo ... | 1996 | 8755503 |
| ["gloves and socks" purpura syndrome caused by human parvovirus b19]. | | 1996 | 8756224 |
| sequence variability among different parvovirus b19 isolates. | parvovirus b19 is the causative agent of a variety of clinical manifestations, ranging from asymptomatic to severe infection. the basis for this complex pattern of b19-associated diseases is as yet poorly understood. in general there are two different possibilities: firstly, the infected individuals may have a genetic or acquired predisposition, which renders them susceptible for a certain course of infection; secondly, differences in the b19 genome may result in different outcomes of infection. ... | 1996 | 8760426 |
| [parvovirus b19 infection. current status]. | | 1996 | 8761790 |
| identification of domains in canine parvovirus vp2 essential for the assembly of virus-like particles. | canine parvovirus capsids are composed of 60 copies of vp2 and 6 to 10 copies of vpl. to locate essential sites of interaction between vp2 monomers, we have analyzed the effects of a number of vp2 deletion mutants representing the amino terminus and the four major loops of the surface, using as an assay the formation of virus-like particles (vlps) expressed by recombinant baculoviruses. for the amino terminus we constructed three mutants with progressively larger deletions, i.e., 9, 14, and 24 a ... | 1996 | 8764053 |
| parvovirus b19 infection and idiopathic thrombocytopenic purpura. | the potential association of human parvovirus b19 infection with idiopathic thrombocytopenic purpura (itp) was studied. all 60 adult patients presenting with itp at the university hospital rotterdam - dijkzigt during a 12-year period (41 with acute itp, 19 with chronic itp) were included. patient files were retrospectively analyzed. stored serum samples were tested for parvovirus b19-specific igg and igm anti-bodies, and for parvovirus b19 dna. in only one patient (1.7%) was evidence of recent b ... | 1996 | 8766256 |
| sequence analysis of a parvovirus b19 isolate and baculovirus expression of the non-structural protein. | serology for parvovirus b19 has been hampered by limited availability of antigen which has often had to be isolated from viraemic blood donations. we have determined the sequence of the genome of one such isolate (stu). it is 99% similar to the sequences of two other isolates (wi and au) except at the far 5'-end, where it is more similar to the terminus of another isolate (ala/alb). recombinant nonstructural protein, ns, was constructed. antibodies to ns, as well as to the capsid proteins, vp1/2 ... | 1996 | 8774690 |
| kawasaki disease and human parvovirus b19 antibody: role of immunoglobulin therapy. | | 1995 | 8775567 |
| association of parvovirus b19 infection with giant cell arteritis. | | 1996 | 8783735 |
| [hydrops fetalis due to parvovirus b19 infection]. | | 1996 | 8785581 |
| parvovirus b19 as a trigger for spontaneous bacterial peritonitis in a patient with cirrhotic ascites. | | 1996 | 8792717 |
| adeno-associated virus 2-mediated transduction and erythroid lineage-specific expression in human hematopoietic progenitor cells. | | 1996 | 8794248 |
| lymphoproliferative responses after infection with human parvovirus b19. | immunity after infection with the parvovirus b19 is assumed to be conferred by a humoral immune response with development of neutralizing antibody. in contrast, little is known about the nature of t-cell-mediated responses to parvovirus b19 infection in humans. we used recombinant proteins vp1, vp2, and ns1, as well as a recombinant vp1-specific amino-terminal sequence, to test the proliferative responses of peripheral blood mononuclear cells after infection of otherwise healthy individuals with ... | 1996 | 8794392 |
| transfusion-transmitted disease. | many patients with haemophilia are infected with viruses, due to treatment with blood products--particularly from large pool clotting factor concentrates before 1985. aids in haemophilic patients was first described in 1982 and it has significantly reduced the life expectancy of these patients. although no new sero-conversions have occurred since 1986, management of hiv in haemophilia remains a clinical challenge. transfusion-associated hepatitis was recognized in 1943, and it is now an importan ... | 1996 | 8800511 |
| myopericarditis due to parvovirus b19 in an adult. | | 1996 | 8816166 |
| parvovirus b19 outbreak in a developmental center. | of 49 employees serving developmentally disabled persons, 13 (27%) were found to have parvovirus b19 infection on the basis of serum positivity for parvovirus b19 igm by enzyme-linked immunosorbent assay. two employees had severe peripheral symmetric polyarthropathy lasting longer than 6 months. infection control measures are described. | 1995 | 8821114 |
| a case of early intrauterine parvovirus b19 infection. | we present a case of parvovirus b19 infection in the first trimester, confirmed by polymerase chain reaction (pcr) in amniotic fluid and cord blood, that caused myocarditis, severe intrauterine growth retardation, and probably glomerulonephritis. eventually a small-for-dates neonate was born, without any signs of the infection. | 1996 | 8821857 |
| infectious causes of hydrops fetalis. | a variety of infectious agents have been associated with nonimmune hydrops fetalis, most notably parvovirus b19, cytomegalovirus, herpes simplex virus, toxoplasma gondii, and treponema pallidum. these agents produce hydrops through effects on fetal bone marrow, myocardium, or vascular endothelium. knowledge of the epidemiology and clinical characteristics of maternal and fetal infection can be used to select a diagnostic approach. etiologic diagnosis will guide prognosis and the selection of spe ... | 1995 | 8822333 |
| stillbirths and maternal antibodies to chlamydia trachomatis. a new eia test for serology. | the relationship between stillbirths and infections during pregnancy. | 1996 | 8822661 |
| circulating hematopoietic stem cell populations in human fetuses: implications for fetal gene therapy and alterations with in utero red cell transfusion. | circulating progenitor cell populations in normal human fetuses and fetuses with various hematological problems were evaluated. thirty blood samples from 21 human fetuses (17-36 weeks of gestation) were assayed for erythroid, myeloid, and mixed-cell progenitor cells. the mean number of progenitor cells/10(4) blood mononuclear cells in the normal fetal population was 103 +/- 47. granulomonocytic and mixed progenitor cells (capable of giving rise to both erythroid and myeloid progeny) were the pre ... | 1996 | 8823602 |
| human parvovirus infection: rheumatic manifestations, angioedema, c1 esterase inhibitor deficiency, ana positivity, and possible onset of systemic lupus erythematosus. | to investigate the clinical and serological characteristics of parvovirus infection. | 1996 | 8823689 |
| acute bilateral carpal tunnel syndrome associated with human parvovirus b19 infection. | human parvovirus b19 has been described as a causative agent of erythema infectiosum (a disease common in children), aplastic crisis in patients with hemolytic disorders, and arthralgias and arthritis. joint involvement may be a prominent clinical feature of parvovirus b19 infection and may last for several weeks. we describe three cases of acute bilateral carpal tunnel syndrome associated with parvovirus b19 infection as evidenced by serological data and, in one case, by detection of parvovirus ... | 1996 | 8824988 |
| high seroprevalence of parvovirus b19 among patients infected with human immunodeficiency virus. | | 1996 | 8825012 |
| follow-up study of clinical and immunological findings in patients presenting with acute parvovirus b19 infection. | this study was undertaken to examine the natural history of parvovirus b19 infection in persons without a known immune defect in terms of both clinical symptoms and immune responsiveness to the virus. fifty-three patients with acute b19 infection (positive for serum anti-b19 igm) were studied; symptoms at acute infection were rash and arthralgia (n = 26), rash (n = 7), arthralgia (n = 16), aplastic crisis (n = 3), and intrauterine fetal death (n = 1). patients were followed for 26-85 months (mea ... | 1996 | 8825713 |
| parvovirus b19 infection in a liver transplant recipient: case report and review in organ transplant recipients. | we report an adult liver transplant recipient with parvovirus b19 infection, presenting as chronic transfusion-dependent anemia ensuing 1 month post-transplantation. both serum and bone marrow cells were positive for parvovirus b19 dna detected by polymerase chain reaction. the bone marrow biopsy revealed erythroid hypoplasia with a selective decrease of nucleated red cell precursors, and giant pronormoblasts with prominent intranuclear inclusions, characteristic of parvovirus b19 infection. ane ... | 1996 | 8826660 |
| [juvenile chronic arthritis (jca) or chronic arthropathy due to parvovirus b19?]. | | 1996 | 8830576 |
| the prevalence of antibody to parvovirus b19 in hemophiliacs and in the general population. | the prevalence of antibodies to parvovirus b19 (b19) was measured in the sera of 566 hemophiliacs and 524 individuals of the general population by immunofluorescence assays, using antigen expressed by the baculovirus system. in the general population, anti-b19 igg seroprevalence was found to continuously decline from 64 percent at birth to 0 percent in the age of 9-11 months and thereupon to increase to 61 percent in the age of 12 years. in younger adults and older people, igg seroprevalence onl ... | 1996 | 8837383 |
| synchronous variations of the incidence of temporal arteritis and polymyalgia rheumatica in different regions of denmark; association with epidemics of mycoplasma pneumoniae infection. | the etiology of temporal arteritis (ta) and polymyalgia rheumatica (pmr) is unknown, but the sudden onset and the wide variation in incidence reported from various parts of the world suggest the existence of environmental and/or genetic factors. we studied the incidence of ta and pmr during a 12 year period in different regions of denmark. | 1996 | 8838518 |
| a case of prolonged human parvovirus b19 dna-emia associated with polyclonal b cell activation. | the current paper reports an 8 year old girl with arthralgia and polyclonal b cell activation induced by human parvovirus b19 infection (hpv b19). the infection was diagnosed by the presence of the virus genome in sera. the patient presented with transient arthritis in the wrist, ankle joint and neck and elevation of immunoglobulin igm antibodies to hpv b19 and rubella, antibodies to mycoplasma and antistreptolysin o but without the typical clinical features of erythema infectiosum. the polyclon ... | 1996 | 8840543 |
| b19 parvovirus infection and transient aplastic crisis in a child with sickle cell anemia. | transient aplastic crisis is reported in a young child with sickle cell anemia with acute b19 parvovirus infection. she also developed acute chest syndrome and bone marrow/bone infarction involving the right ilium. the clinically unsuspected bone marrow infarction in this patient may have contributed to acute chest syndrome secondary to pulmonary fat embolism. transient cessation of erythropoiesis as a result of b19 parvovirus infection, and not the localized bone marrow infarction, was the prob ... | 1996 | 8846133 |
| acute transient hemolytic anemia with a positive donath-landsteiner test following parvovirus b19 infection. | a case of childhood acute hemolytic anemia following parvovirus infection provided an hypothesis for the high frequency of donath-landsteiner antibodies and inappropriately low reticulocyte counts in this disease. | 1996 | 8846134 |
| insulin-dependent diabetes mellitus associated with parvovirus b19 infection. | | 1996 | 8849170 |
| autoantibodies following parvovirus b19 infection. | this study was undertaken to assess the incidence and significance of autoantibody production following b19 infection, 53 patients with acute b19 infection (positive for serum anti-b19 igm) were studied; symptoms were rash and arthralgia (n = 26), rash (n = 7), arthralgia (n = 16), aplastic crisis (n = 3), and intrauterine death (n = 1). these patients were followed for 26-85 months (mean 57 months) and re-assessed for persistent symptoms, serum anti-b19 antibodies, and serum autoantibodies. at ... | 1996 | 8852550 |
| analysis of serological surveys using mixture models: application to a survey of parvovirus b19. | a method for the analysis of age stratified antibody prevalence surveys is developed. the age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. this yields maximum likelihood estimates of the prevalence at each age. the method is illustrated using data from a previously reported survey of antibody to parvovirus b19. | 1996 | 8855482 |
| index of suspicion. case 1. diagnosis: erythema infectiosum (ei). | | 1996 | 8857202 |
| viral arthritis. | viral infections can present with different patterns of joint and soft tissue involvement, and the etiologic role of viruses in various rheumatic diseases is a subject of continued great interest. recently, new immunoenzymatic assays have brought a better understanding of the relationship between hepatitis c virus serotypes and their immunologic manifestations. our knowledge of the consequences of parvovirus b19 infection has broadened to include the variable clinical spectrum the role of inflam ... | 1996 | 8864586 |
| the effects of human parvovirus b19 and cytomegalovirus during pregnancy. | human parvovirus b19 and cytomegalovirus (cmv) are two common viruses that can have significant and devastating effects on a fetus. maternal infection may lead to vertical transmission of the virus to the fetus. parvovirus infection in the fetus may cause miscarriage, nonimmune hydrops, or demise. fetal cmv infection can cause a number of problems, including nonimmune hydrops and neurosensory disabilities. nurses who are knowledgeable about possible viral effects during pregnancy can collaborate ... | 1996 | 8868625 |
| human parvovirus b19 infection within a family and risk for pregnant women. | during an outbreak of parvovirus b19 infection among four related families at least 70% of the household contacts, including a woman at the 33rd week of pregnancy, became infected. twins were born at the 39th week of pregnancy, both with b19 infection. b19 dna was detected in their sera by a nested pcr, anti-b19 igm was detectable only by an immunofluorescence assay, and low levels of maternal anti-b19 igg were demonstrable by an immunoenzymatic test in the serum of both children. all the haemat ... | 1996 | 8870639 |
| papular-purpuric gloves-and-socks syndrome. | papular-purpuric gloves-and-socks syndrome (ppgss) is a recently described dermatosis in which human parvovirus b19 (hpv b19) has been implicated as etiologic agent; however, it is suspected that ppgss may be caused by various agents. this study was designed to survey the general characteristics of ppgss and to determine the role of hpv b19 in its etiology. | 1996 | 8876288 |
| transient aplastic anemia caused by parvovirus b19 infection in a heart transplant recipient. | parvovirus b19 infection in the transplant patient is rarely reported, although cases have occurred in patients with bone marrow, liver, and renal transplants and in children undergoing heart transplantation. we present the first reported case of an orthotopic heart transplant recipient with aplastic crisis caused by parvovirus b19. the infection was diagnosed by bone marrow biopsy, confirmed by serologic studies and polymerase chain reaction, and successfully treated with intravenous immunoglob ... | 1996 | 8878766 |
| parvovirus b19 and acute joint swelling in rheumatoid arthritis patients. | | 1996 | 8882139 |
| antenatal human parvovirus b19 infection and nonimmune hydrops fetalis presenting as severe preeclampsia. | | 1996 | 8883769 |
| infections caused by parvovirus b19. | parvovirus b19 was discovered in 1974 by cossart et al; is a single stranded unenveloped dna virus, which virion is isometric, uniform and has icosagedral symmetry. b19 infection has been found in all countries, it is almost certainly world-wide in distribution. infections occurs most frequently in late winter, spring and early summer months and are transmitted by respiratory route. erythema infectiosum is the most common manifestation of human parvovirus b19 infection, is most commonly acquired ... | 1996 | 8885443 |
| seroprevalence of human parvovirus b19 in children of a desert region. | a seroepidemiological study was conducted in kuwait to evaluate the pattern of acquisition of human parvovirus b19 by children in kuwait and to compare it with patterns described in other regions in different climatic zones. a total of 218 serum samples from children less than 16 years of age were tested for the presence of anti-b19 igg by enzyme immunoassay. the overall seroprevalence was 17.4%. infants in kuwait had low levels of maternally-acquired anti-b19 igg (8.6%). the age of peak exposur ... | 1996 | 8893957 |
| a case of parvovirus-b19 adult acute arthritis with some allergic disease clinical features. | a 31-year old woman suddenly presented arthralgias at wrists, knees and feet, swelling of eyelids and the upper lip, itching behind the ears, fever and macular rash on the extensory surface of legs, face and back. signs and symptoms were strongly suggestive of an allergic reaction but human parvovirus-b19 serology was positive, ige serum levels were normal, skin prick tests and rast for aliments were negative. joint symptoms and swelling diminished in about four weeks. the relationship between t ... | 1996 | 8894369 |
| comparative evaluation of virological and serological methods in prenatal diagnosis of parvovirus b19 fetal hydrops. | human parvovirus b19 infection in pregnancy represents a potential hazard to the fetus since fetal loss or fetal hydrops can occur. the risk of fetal loss due to transplacental b19 transmission has been evaluated in several studies using different diagnostic methods on maternal and fetal specimens. we analyzed the diagnostic value of virological and serological techniques on maternal serum, fetal cord blood, and amniotic fluid specimens obtained at the time of clinical diagnosis of fetal hydrops ... | 1996 | 8904423 |
| parvovirus b19 in hiv infection: a treatable cause of anemia. | we describe the case of an adult male patient with aids who presented with severe anemia and on investigation was found to have red cell aplasia due to parvovirus b19 infection. bone marrow examination revealed absence of erythroid development and rare giant pronormoblasts. repeated serological examinations revealed a low level of parvovirus igm but no igg. viremia was demonstrated by electron microscopy and by the polymerase chain reaction (pcr). the patient's initial hemoglobin was 45 g/l and ... | 1996 | 8912362 |
| parvovirus b19 in anemic liver transplant recipients. | five hundred thirty-three liver transplant recipients were seen for follow-up care over a 6-month period. of these, 23 (4.3%) had a hemoglobin level of < or = 9 g/dl, with 19 being eligible for inclusion in this study. the median hemoglobin level was 8.7 g/dl. two patients had iron-deficiency anemia. all of the patients were on therapeutic drugs which can suppress erythropoiesis or shorten the lifespan of mature erythrocytes. six patients (31.6%) were viremic for human parvovirus b19 but none wa ... | 1996 | 8914771 |
| immunohistochemical and virological study of skin in the papular-purpuric gloves and socks syndrome. | the pathogenesis of viral exanthems remains unclear. we have undertaken an immunohistochemical study of lesional skin biopsies in patients with the papular-purpuric gloves and socks syndrome (ppgss) secondary to parvovirus b19 infection. intracytoplasmic staining of the dermal endothelial cells, keratinocytes, and sweat glands was shown with an antibody to parvovirus b19. there were perivascular dermal infiltrates with t cells, sometimes with exocytosis. by polymerase chain reaction, virus dna w ... | 1996 | 8915154 |
| [a case with petechiae due to human parvovirus b19]. | we reported a case of 10-year-old girl with petechiae mainly on the truncus, although who had more than 10 x 10(4)/microliter of platelets. smears of her bone marrow demonstrated extreme reduction of erythroblasts with giant proerythroblast like cells, which does not consist with idiopathic thrombocytopenic purpura. human parvovirus b19 (b19) dna was detected in her serum and throat swab using pcr and significant alterations of b19 specific igm and igg antibody titers were demonstrated. the pete ... | 1996 | 8921682 |
| genetic diversity of human parvovirus b19: sequence analysis of the vp1/vp2 gene from multiple isolates. | to evaluate the genetic variability of human parvovirus b19, the complete coding region of the vp1/vp2 structural proteins of 29 b19 isolates obtained from 25 infected patients were sequenced and compared with each other and with two previously published b19 isolates. the vp1/vp2 gene was amplified by pcr using b19-specific oligonucleotide primers and the amplification products were sequenced directly. overall, the average nucleotide and predicted amino acid identity among b19 isolates was high. ... | 1996 | 8922470 |
| evaluation of four commercial enzyme immunoassays for detection of immunoglobulin m antibodies to human parvovirus b19. | four commercial enzyme immunoassays (eias) for the detection of parvovirus b19-specific immunoglobulin m (igm) antibodies [biotrin parvovirus b19 igm (biotrin international, ireland); parvoscan b19 igm (euro-diagnostica, sweden); parvovirus igm (immunobiological laboratories [ibl], germany); and human parvovirus b19 igm (hillcrest biologicals, usa)] were compared to indirect immunofluorescence assay (ifa) and polymerase chain reaction (pcr). using ifa as the reference test, high sensitivities (> ... | 1996 | 8922581 |
| spontaneous resolution of non-immune hydrops fetalis secondary to transplacental parvovirus b19 infection. | we report a case of hydrops fetalis secondary to transplacental parvovirus b19 infection, in which spontaneous resolution of the hydrops occurred 4 weeks after the initial presentation. this case emphasizes the role of conservative management based on ultrasound evidence of continued resolution of the hydrops and intrauterine growth retardation. | 1996 | 8932634 |
| severe shwachman-diamond syndrome and invasive parvovirus b19 infection. | parvovirus b19 (pvb19) is the causative agent of infectious erythema. in healthy children the virus causes transient erythroid aplasia, whereas in children with chronic hemolytic anemias it can cause severe aplastic crises, and in immunodeficient individuals it can produce chronic red cell aplasia. if contracted during pregnancy, the infection may induce serious damage to the fetus (abortion or hydrops fetalis). shwachman-diamond (s-d) syndrome, a rare autosomal recessive condition, consists of ... | 1996 | 8940740 |
| erythrocyte p antigen in beta thalassemia major patients with human parvovirus-b19 infection. | | 1996 | 8940744 |
| drug-induced pure red cell aplasia. | pure red cell aplasia (prca) is an uncommon hematologic disorder characterized by the absence of erythroblasts in otherwise normal bone marrow. it is commonly an autoimmune disorder sometimes associated with a congenital error. it may also be acquired in association with thymomas, hematologic malignancies, human parvovirus b19 infection, drugs, and other disease states. thirty drugs have been implicated as causative in prca, but most literature reports describe only one or two patients. data eva ... | 1996 | 8947971 |
| [cutaneous manifestations of parvovirus b19 infection]. | parvovirus b19 can cause a wide range of cutaneous or extracutaneous diseases. there are three types of exanthemas, erythematous maculopapulous or vesicopapulous exanthema including erythema infectiosum, the less common maculoerythematous exanthemas and purpural exanthemas including vascular, thrombocytopenic or non-vascular or non-thrombopenic forms such as le socks and gloves syndrome. reports of other manifestations have been more sporadic: generalized livedo, polymorphous rash, lupus-like ra ... | 1996 | 8949610 |
| b19 parvovirus withstands "super heating" in antihemophilic concentrates. | | 1996 | 8950802 |
| prevalence of parvovirus b19 infection in patients infected with human immunodeficiency virus. | parvovirus b19 infection may cause chronic anemia in human immunodeficiency virus (hiv)-infected hosts. small-scale studies and case reports have suggested that parvovirus b19 infection is a significant cause of anemia in hiv-infected patients. we studied single serum samples from 317 consecutive hiv-infected patients with use of parvovirus b19-specific serology and polymerase chain reaction for detection of viral dna. anemia was noted in 176 patients (55.5%); 126 (39.9%) had < 0.10 x 10(9) cd4+ ... | 1996 | 8953068 |
| various associations of human parvovirus b19 infection. | a variety of diseases encountered in association with human parvovirus b19 infection seen at paediatric clinic during 6 months is presented and their relation to parvovirus b19 is discussed. we conclude that investigation of parvovirus b19 in variable diseases by using the newly developed methods of molecular biology will enlighten many etiopathogenetic mechanisms. | 1996 | 8961710 |
| fatal fat embolism syndrome in a child with undiagnosed hemoglobin s/beta+ thalassemia: a complication of acute parvovirus b19 infection. | anemia, mental status changes, and fatal respiratory failure complicated a febrile illness in a previously healthy 14-year-old black female. at autopsy, widespread fat emboli and bone marrow necrosis were found. hemoglobin electrophoresis on an antemortem, pretransfusion specimen revealed hemoglobin s/beta+ thalassemia. acute parvovirus b19 (pv b19) infection was suspected. postmortem serum and a variety of paraffin-embedded tissues were assayed for pv b19 dna using the polymerase chain reaction ... | 1996 | 8963632 |
| aplastic anemia in a cardiac transplant recipient. | | 1996 | 8970232 |
| a cytotoxic nonstructural protein, ns1, of human parvovirus b19 induces activation of interleukin-6 gene expression. | we examined the biological function of a nonstructural regulatory protein, ns1, of human parvovirus b19. because of the cytotoxic activity of ns1, human hematopoietic cell lines, k562, raji, and thp-1, were established as transfectants which produce the viral ns1 protein upon induction by using bacterial lactose repressor/operator system. ns1 was significantly produced in the three transfectant cells in an inducer dose- and time-dependent manner. surprisingly, these three transfectants secreted ... | 1996 | 8970971 |
| parvovirus b19 dna is frequently present in recombinant coagulation factor viii products. | | 1996 | 8972042 |
| human parvovirus b19 associated non-immune hydrops fetalis. | | 1996 | 8991362 |
| parvoviruses and bone marrow failure. | parvovirus b19, the only known human pathogenic parvovirus, is highly tropic to human bone marrow and replicates only in erythroid progenitor cells. the basis of this erythroid tropism is the tissue distribution of the b19 cellular receptor, globoside (blood group p antigen). in individuals with underlying hemolytic disorders, infection with parvovirus b19 is the primary cause of transient aplastic crisis. in immunocompromised patients, persistent b19 infection may develop that manifests as pure ... | 1996 | 8991535 |
| evaluation of serological assays for identification of parvovirus b19 immunoglobulin m. | three different enzyme immunoassays (eias) (parvoscan-b19, ibl parvovirus b19, and ideia parvovirus b19) and one immunofluorescence assay (biotrin parvo b19 ifa) were evaluated for detection of parvovirus b19 immunoglobulin m (igm) antibodies in 203 clinical serum samples. an igm antibody capture radioimmunoassay was used as a reference test. serum specimens obtained from patients with clinical symptoms suggestive of parvovirus b19 infections were used to evaluate the sensitivities of the assays ... | 1996 | 8991627 |
| antibody response to human parvovirus b19 in patients with primary infection by immunoblot assay with recombinant proteins. | human parvovirus b19 recombinant vp1 and vp2 capsid proteins were produced by a procaryotic pgex expression plasmid to evaluate the humoral response by immunoblot assay in 14 patients with primary infection. the same concentrations of vp1 and vp2 recombinant proteins were used. this demonstrates that vp1 immunoglobulin m detection and/or vp1 immunoglobulin g seroconversion is a reliable marker of primary infections. consequently, detection of antibodies to b19 vp1 might be helpful for identifyin ... | 1996 | 8991644 |
| [what is your diagnosis? arthritis caused by human parvovirus b 19 (hpv b19 arthritis)]. | | 1996 | 8992571 |
| human parvovirus b19 infections among exanthematic diseases notified as measles. | a total of 1397 sera collected from 1095 cases of exanthematic disease notified as measles in es and rj states during july 1992 to december 1994 were investigated. these sera were first tested for measles and rubella specific igm. when they proved negative, they were tested for b19 specific igm by an enzyme immunoassay. b19 infection was confirmed in 27 (2.5%) of these cases. sera from 194 negative cases for measles and rubella igm received from other brazilian states were also investigated and ... | 1996 | 8993105 |
| pure red cell aplasia caused by b19 parvovirus infection after autologous blood stem cell transplantation in a patient with chronic lymphocytic leukemia. | | 1997 | 9001436 |
| congenital cardiomyopathy associated with human parvovirus b19 infection. | | 1997 | 9006302 |
| bilateral brachial plexus neuritis following parvovirus b19 and cytomegalovirus infection. | a man, 23 years of age, had a typical erythema infectiosum, complicated by a severe bilateral brachial plexus neuritis. motor function recovered slowly and only partially after 6 months. an infection by human parvovirus b19 was demonstrated, with strongly positive and gradually declining igm antibodies and viral dna detectable in serum for more than 3 months. there was also clear evidence of a recent infection by cytomegalovirus. the interaction between these two viruses could be responsible for ... | 1996 | 9007101 |
| similarities of specificity and cofactor dependence in serum antiphospholipid antibodies from patients with human parvovirus b19 infection and from those with systemic lupus erythematosus. | to assess the phospholipid specificity and immunoglobulin isotype of antiphospholipid (apl) antibodies in patients with acute parvovirus b19 infection. | 1997 | 9008606 |
| establishment of a cell line expressing human parvovirus b19 non-structural protein from an inducible promoter. | human parvovirus b19 non-structural (ns) protein is supposed to play a major role in b19 replication and transcription, and therefore in b19 pathogenicity. constitutive expression of ns protein in stable cell lines has failed so far, presumably because of its cytotoxicity. to avoid this cytotoxic effect, we have cloned the ns gene in an epstein-barr virus episomal vector under the control of a steroid inducible promoter (5xgre) and transfected this construction into hela cells. we obtained stabl ... | 1997 | 9010306 |
| parvovirus b19 infection and rheumatic diseases. | we reviewed the literature on relationships between human parvovirus b19 infection and rheumatic diseases. parvovirus b19 causes erythema infectiosum in childhood, transient anemia in immunocompetent individuals, and potentially severe infections in fetuses; laboratory evidence that the virus is directly responsible for these disorders has been obtained. acute arthropathy meeting american college of rheumatology criteria for rheumatoid arthritis and disorders meeting some of the classification c ... | 1996 | 9010973 |
| rheumatic manifestations due to human parvovirus b19. a report of four cases. | human parvovirus b19 has been incriminated in the genesis of hematologic, dermatologic, neurologic, and rheumatic disorders. we report four cases in which inflammatory rheumatic manifestations developed during the course of human parvovirus b19 infection documented by the presence of igm and igg antibodies. there was one case each of monoarthritis, oligoarthritis, polyarthritis, and enthesitis. three patients had a favorable outcome under nonsteroidal antiinflammatory drug therapy, and one devel ... | 1996 | 9010974 |