| cyclic nucleotide phosphodiesterases of the renal cortex. characterization of basal-lateral membrane activities. | | 1977 | 21299 |
| nonstructural proteins of herpes simplex virus. i. purification of the induced dna polymerase. | herpes simplex virus-induced dna polymerase purified by published methods was found to be contaminated with many others proteins, including virus structural proteins. thus, deae-cellulose and phosphocellulose chromatography were used in combination with affinity chromatography to purify dna polymerase from herpes simplex virus type 1- and type 2-infected cells. the purified enzyme retained unique features of the herpesvirus-induced dna polymerase, including a requirement for high salt concentrat ... | 1977 | 21304 |
| prostaglandin synthetase systems in rat and rabbit renal medulla and inhibition by non-steroidal anti-inflammatory drugs. | the properties of prostaglandin synthetase systems (psss) in the renal medulla of the rat and rabbit, and inhibition by ketoprofen, indomethacin, ibuprofen, phenylbutazone and aspirin were investigated in relation to their anti-inflammatory, analgesic, antipyretic and ulcerogenic activities. rat and rabbit psss produced prostaglandin (pg)e and pgf from arachidonic and dihomo-gamma-linolenic acids and had an optimal ph of 8.5 and 7.5 for pge formation, respectively. only a slight loss of activity ... | 1977 | 21319 |
| detection of circulating immune complexes with a modified raji cell technique. | a modification of the raji cell technique for the detection of circulating immune complexes is described. raji lymphoid cells bind immune complexes via the c 3 receptor. prior to incubation with the test serum it is necessary to block the igg fc receptor which would interfere with the assay. in the present modification the igg fc receptor is blocked with monoclonal igg myeloma proteins thereby facilitating the detection of c 3 bound immune complexes with fluoresecein-conjugated anti-light chain ... | 1977 | 21324 |
| the pharmacology of antihypertensive drugs with special reference to vasodilators, alpha-adrenergic blocking agents and prazosin. | | 1977 | 21341 |
| centrally active drugs and the sympathetic nervous system of rabbits and cats. | | 1977 | 21359 |
| comparative study of beta andreoceptor antagonists on the isolated atria of control and of the reserpine treated rabbits. | the effect of four adrenoceptor antagonists, chosen because of reported differences in their selectivities, were compared using the positive chronotropic response to isoprenaline on isolated rabbit atria. oxprenolol was the most potent antagonist of the isoprenaline induced cardiac arrhythmias. alprenolol, practolol and propranolol also blocked the positive chronotropic responses to isoprenaline effectively. all the antagonists lowered the resting heart rate. the effects of all four selected ant ... | 1977 | 21372 |
| effect of carbonic acid concentration in blood on content of keto-acids and redox state of nicotinamide coenzymes in rabbit tissues. | a rise in the level of carbonic acid in animal blood at practically unchanged ph causes an increase in the value of free nad+/nadh and nadp+/nadph ratios in the liver cells cytoplasm. the increase in the oxidizing power of the liver cells cytoplasm is observed against a background of a rise in both the total level of keto-acids in blood and concentration of pyruvate oxaloacetate and alpha-ketoglutarate in the liver and kidneys of animals. the level of lactate, glutamate and citrate in these tiss ... | 1977 | 21480 |
| in vitro interactions of di-, tetra- and hexa-chlorobiphenyl with rabbit liver monooxygenase. | | 1977 | 21666 |
| rabbit liver transglutaminase: physical, chemical, and catalytic properties. | transglutaminase (r-glutaminyl-peptide:amine alpha-glutamyl-yltransferase ec 2.3.2.13) has been purified to apparent homogeneity from extracts of rabbit liver. the enzyme is a single polypeptide chain of approximately 80 000 molecular weight containing one catalytic site per molecule. that the isolated enzyme is the rabbit counterpart of the well-characterized guinea pig liver transglutaminase is evidenced by the similarities in their amino acid compositions and in their enzymic activities towar ... | 1977 | 21685 |
| alteration of exogenous norepinephrine caused by electrical 'field' stimulation and its role in poststimulant relaxation. | | 1977 | 21734 |
| effect of diazoxide, verapamil and compound d600 on isoproterenol and calcium-mediated dose-response relationships in isolated rabbit atrium. | the effect of diazoxide, verapamil and compound d600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. all three agents shifted calcium dose-force relationships parallel and to the right. d600 acted as a competitive antagonist of calcium, as a plot of log (x - 1) vs. -log b resulted in a straight line with a slope of approximately -1.0. diazoxide, verapamil and d600 also antagonized isoproterenol but in a non-competitive manner. a r ... | 1977 | 21800 |
| haemodynamic and baroreceptor responses to beta-adrenoceptor blocking agents in rabbits with cardiopulmonary bypass. | blood pressure and peripheral resistance were reduced, baroreceptor activity was enhanced after i.v. infusion of beta-adrenoceptor blocking agents in rabbits with intact circulation or with total cardiopulmonary bypass. the latter preparation allowed cardiac effects of the drugs to be excluded. in rabbits with an intact circulation, post-ganglionic sympathetic activity was reduced. these results suggest a direct vascular action of the drugs. the increased baroreceptor firing is not a cardiac-med ... | 1977 | 21801 |
| the mode of contractile action of palytoxin on vascular smooth muscle. | experiments were designed to assess the mode of action of palytoxin (ptx), isolated from palythoa tuberculosa, on mechanically denervated rabbit aortic strips. ptx induced a sustained contraction in the muscle dose dependently. the contraction was irreversible. in the depolarized aorta, ptx did not induce a contraction whereas norepinephrine (ne) did. removal of calcium from the bathing medium prevented ptx and high k+ contractions, whereas phasic responses were elicited by ne. d600 also inhibit ... | 1977 | 21803 |
| effects of palytoxin on the electrical activity of dog and rabbit heart. | reversible effects of palytoxin, extracted from colonies of the soft coral palythoa caribaeorum, are described. there is a decrease of both membrane resting potential and overshoot during activity. rise time of the action potential is prolonged, while repolarization is shortened. the electrical events resemble those seen with metabolic poisons. | 1977 | 21804 |
| rabbit intestinal fluid stimulation by an enterotoxigenic factor of staphylococcus aureus. | an exoprotein of staphylococcus aureus 100 that elicited a positive ileal loop response in the rabbit model was investigated in this study. the protein, as it occurred in the culture supernatant fluid, could be detected initially in the late log phase of growth under aerobic and anaerobic conditions. it was stable under acidic conditions to ph 2.0 after 24 h at 4 degrees c. thirty-minute treatments at 80 degrees c destroyed the ileal loop activity whereas similar trials at 70 degrees c had no ef ... | 1977 | 21850 |
| effects of denervation on the neuraminidase activity of slow and fast muscles of rabbits. | the presence in skeletal muscles of rabbits of neuraminidase activity on sialyl lactose was demonstrated. by comparing the specific activity of this enzyme in different control muscles, it was shown that it was 2.3 times higher in the slow than in the fast muscles. seven days after denervation, we observed a significant increase of activity in fast muscle and a significant decrease of activity in slow muscle. these results, together with previous data, are in favour of the hypothesis that turnov ... | 1977 | 21944 |
| effect of ammonium chloride on the excretion of chloroquine in rabbit urine (author's transl). | | 1977 | 21946 |
| cause of decrease of ethylmorphine n-demethylase activity of lipid peroxidation in microsomes from the rat, guinea pig and rabbit. | there were marked differences among animal species between nadph-dependent and ascorbic acid-fe++-dependent lipid peroxidation. in nadph-dependent lipid peroxidation, this activity occurred to the greatest extent in rats followed by guinea pigs and rabbits and such was much lower in rabbits than in guinea pigs. on the other hand, rabbit microsomes exhibited higher lipid peroxidation activity than guinea pigs in ascorbic acid plus fe++ or fe++-dependent lipid peroxidation although the activity wa ... | 1977 | 21981 |
| antipsychotic drugs block lsd-induced disaggregation of brain polysomes. | | 1977 | 22009 |
| preparation of 125i polypeptide hormones for radioimmunoassay using glucose oxidase with latoperoxidase. | | 1977 | 22011 |
| establishment of the hosts of bloodsucking mosquitoes in abkhazia. 3. fertility of females of mass mosquito species feeding on warm-blooded and cold-blooded animals. | | 1977 | 22029 |
| human leukocytic pyrogen: purification and development of a radioimmunoassay. | leukocytic pyrogen is a small endogenous protein that mediates fever. because of the limitations of bioassays, circulating leukocytic pyrogen has not been demonstrated during fever in humans. the pyrogen was produced in vitro after phagocytosis of staphylococci by blood monocytes. antibody against the pyrogen was obtained from rabbits immunized with leukocytic pyrogen and the antiserum was purified by solid-phase immunoadsorbants. purified antibody to the pyrogen was attached to activated sephar ... | 1977 | 22079 |
| factors affecting the urinary excretion of endogenously formed dimethyltryptamine in normal human subjects. | the hallucinogenic substance n',n'-dimethyltryptamine and its precursor n-methyltryptamine were found in 24-h specimens of urine from 19 normal human subjects; the mean excretion rates were 386 ng 24 h(-1) and 856 ng 24 h(-1) respectively. the urinary excretion of both compounds was unrelated to age, sex, urinary volume, or creatinine, nor was any consistent diurnal pattern observed. rates for the mono and dimethylated compounds were not correlated. diet and the intestinal flora were excluded as ... | 1977 | 22091 |
| amino acid transmitters (author's transl). | | 1977 | 22097 |
| induction of the enzymes related to neurogenic amines (author's transl). | | 1977 | 22098 |
| cyclic nucleotides in brain cells (author's transl). | | 1977 | 22099 |
| psychotropic drugs and adenylate cyclase (author's transl). | | 1977 | 22102 |
| fungal proteases and the mammalian kinin system: i. brinolase-catalyzed kinin formation and s2160 hydrolysis. | brinolase, a fungal protease advocated for thrombolytic therapy, released kinin peptides from semi-purified kininogens of the human, rabbit, guinea pig, and mouse, and moreover cleaved an arginyl bond of the chromogenic peptide s2160. its kinetics demonstrated marked differences from the mammalian protease trypsin. whereas trypsin liberated 100% of the available kinin in 30 min at ph 8, brinolase generated a maximum of only 22% under optimal conditions, viz. incubation of 5 microgram/ml enzyme a ... | 1977 | 22111 |
| an experimental study on the pathogenesis of the acute pulmonary insufficiency (author's transl). | parameters of the lungs as compliance paco2, pao2, have been measured in connection with experimental, pathophysiological insults like hematoma, bone marrow intravasation and hemorrhage, in rabbits. concerning the compliance quotient, a statistically proved decrease was found within the groups, which have had a hematoma. moreover, the histological picture of the lungs from rabbits with a hematom showed perivascular and intersitial edema and considerable atelectases. serum of animals, which have ... | 1977 | 22113 |
| quantitative characteristics of the feyrter (apud) cells of the neonatal rabbit lung in normoxia and chronic hypoxia. | our studies show that the apparent number of feyrter cells in the lung declines during the neonatal period in normoxic rabbits, and that in hypoxic animals a uniformly and significantly lower number of cells occurs as compared with the normoxic rabbits. there is some indication of degranulation of cells in the hypoxic groups. it is suggested that environmental and/or physiological factors associated with the start of extrauterine life, or lung development, may affect the apparent number and prob ... | 1977 | 22136 |
| teratological study of etoperidone in the rat and rabbit. | etoperidone was administered to pregnant rats and rabbits during the period of organogenesis. the oral doses were 100 and 300 mg/kg in the rat and 5, 25 and 50 mg/kg in the rabbit. in the rat the dose of 300 mg/kg produced toxic effects on the mother, consisting mainly of behavioural changes and death in some cases; a slight increase in embryofetal mortality was also observed. the dose of 100 mg/kg still produced behavioural changes in the mother, but had no effect on the product of conception. ... | 1977 | 22143 |
| effect of altitude hypoxia on the erythropoiesis of animals with experimental aregenerative anemia. | | 1977 | 22184 |
| inhibition of transmitter release from isolated rabbit kidney by bradykinin. | the effect of kallikrein on the release of norepinephrine has been studied in the isolated perfused rabbit kidney. kallikrein in the perfusion medium caused an inhibition in the rise of the perfusion pressure induced by periarterial stimulation and in the contraction of rabbit aorta superfused by the venous outflow of the stimulated kidney. on the contrary, kallikrein caused a potentiation in the urine volume induced by periarterial stimulation. similar findings were obtained when bradykinin was ... | 1977 | 22226 |
| some biological properties of an endotoxic lipopolysaccharide from the typhus group rickettsiae. | a lipophilic thermostable lipopolysaccharide (lps) complex was isolated by phenol extraction from purified suspensions of the typhus group rickettsiae. the lps complex is antigenic and possesses some endotoxic properties such as toxicity for actinomycin d-treated mice, pyrogenicity for rabbits and guinea pigs, ability to elicit hypothermia in white rats and local schwartzman reaction and active cutaneous anaphylaxis in rabbits. | 1977 | 22240 |
| polyploidisation - a phenomenon of aging? (author's transl). | by means of cytophotometric determination of dna in different cellular systems an increase in polyploidisation correlated to age could be demonstrated. the latter is well demonstrable if compensatory hyperplasia or hypertrophy occurs. it is discussed that cellular systems of older individuals can increase their dna - content, but they are not able to carry out a caryo-and cytocinesis. | 1977 | 22253 |
| reaction of antibody with gamma-glutamyl transpeptidase. i. isolation of the human enzyme and inhibition of its activity by antiserum. | use of a four-step method of purification from human kidneys yielded gamma-glutamyl transpeptidase with specific activity 330 times higher than activity in the homogenate. the enzyme from human liver was also purified, and from urine two fractions of it were separated. from rabbits immunized with the enzyme from human kidney, antiserum was obtained which inhibits and precipitates the human-derived enzyme, and in a low degree the enzyme purified from bovine kidneys. this inhibition was independen ... | 1977 | 22320 |
| cobalt-activated acylase activity in experimental toxic liver damage. | co++-activated acylase activity was studied in the blood serum and liver homogenates from rabbits poisoned with ccl4 in doses of 0-5 g/kg body weight intraperitoneally. activity of this enzyme in serum increased on the first day after poisoning, but the rise was of short duration. increased serum activity of the enzyme was accompanied by an increase in acylase activity in liver homogenates, which persisted to the ninth day, i.e. to the end of the observation period, when serum acylase activity r ... | 1977 | 22321 |
| antiarrhythmic properties of 5-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (opc-1085), a newly synthesized, potent beta-adrenoreceptor antagonist. | 1. the antiarrhythmic properties of 5-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (opc-1085) were compared with those of propranolol and pindolol using various kinds of preparations for experimental arrhythmia in dogs. 2. although opc-1085 was the most potent drug to antagonize adrenaline-induced arrhythmia in animals anaesthetized with either pentobarbitone sodium or halothane, it was scarcely effective on ouabain-induced arrhythmia in pentobarbitone sodium anaesth ... | 1977 | 22416 |
| transmitter release and adrenergic mechanical responses in the heart: effect of papaverine and imidazole. | chronotropic and inotropic responses were elicited in isolated rabbit hearts by stimulation of the sympathetic nerves or by infusion of noradrenaline or adrenaline and the effects of papaverine and imidazole (10(-7)-10(-6) m) on these responses were studied. the outflow of noradrenaline induced by sympathetic nerve stimulation was assayed in the absence and in the presence of papaverine and imidazole (10(-7)-5 x 10(-7) m). papaverine increased the outflow of transmitter during nerve stimulation ... | 1977 | 22442 |
| ocular antigens vii. the influence of freund's complete adjuvant and corneal structural glycoprotein in xenogeneic keratoplasty. | | 1977 | 22446 |
| the aqueous outflow system and its response to autonomic receptor agonists. | | 1977 | 22449 |
| peripheral cardiovascular dopamine receptors. | | 1977 | 22476 |
| complement-fixing antibody response in pneumococcal pneumonia. | previous studies of complement-fixing antibodies to pneumococcal capsular polysaccharides in humans have yielded conflicting results. we studied 65 sera from 25 patients with pneumococcal pneumonia, using both fresh sera and heat-inactivated sera with added human complement. only 4 of the 25 patients developed detectable levels of complement-fixing anticapsular antibody. of the 25 patients, 22 developed detectable levels of hemagglutinating anticapsular antibody, indicating that they were able t ... | 1977 | 22489 |
| the formation, degradation, and function of cyclic nucleotides in the nervous system. | | 1977 | 22509 |
| lipotropin and the central nervous system. | | 1977 | 22510 |
| tissue fractionation in neurobiochemistry: an analytical tool or a source of artifacts. | | 1977 | 22511 |
| mode of action of hormones on the kidney. | | 1977 | 22560 |
| a simple method to determine gammaglutamyl-cyclotransferase activity in erythrocytes. | a new method for the determination of erythrocyte gammagct is described. the method follows the release of alanine from gammaglutamyl alanine by a series of linked reactions that result in the oxidation of nadh to nad. the ph optimum for human erythrocyte gammagct was found to be 9.0, and the km for gammaglutamyl alanine was found to be 2.3 x 10(-3) m. human erythrocytes had the highest activity of all the species studied (human, rabbit, dog, sheep, cattle, chicken). | 1978 | 22573 |
| central antagonism of tyramine-induced systemic hypotension by mescaline. | | 1977 | 22607 |
| identification of the in vitro n-oxidized metabolites of (+)- and (-)-n-benzylamphetamine. | this study has identified (+)- and (-)-n-benzyl-n-hydroxyamphetamine as metabolites after incubation of both (+)- and (-)-n-benzylamphetamine with fortified rabbit liver homogenates. the isomeric hydroxylamine metabolites were identified using the techniques of g.l.c., t.l.c. and combined g.l.c.-mass spectrometry (ms) and by comparison with results from reference samples. an additional novel metabolic product was identified after incubation of n-benzylamphetamine which had properties consistent ... | 1977 | 22624 |
| bupropion hydrochloride ((+/-) alpha-t-butylamino-3-chloropropiophenone hcl): a novel antidepressant agent. | | 1977 | 22628 |
| difference in the mechanisms by which acetylcholine and histamine interact with ca2+ to contract the rabbit taenia coli. | | 1977 | 22631 |
| quantitative structure-activity study of inhibition of blood platelet aggregation by aspirin derivatives proceedings. | | 1977 | 22708 |
| the metabolism of n-heterocycles proceedings. | | 1977 | 22711 |
| calcium binding by troponin-c. a proton magnetic resonance study. | | 1977 | 22761 |
| enhancement of nadph-dependent lipid peroxidation activity by ethylene-diamineteraacetic acid (edta) in the presence of ferrous ion in rabbit liver microsomes. | the addition of edta to the incubation mixture containing rabbit liver microsomes and ferrous ion resulted in 2-fold increase of lipid peroxidation activity. such an enhancement was not observed in rat liver microsomes. the maximum lipid peroxidation activity seen in rabbit microsomes in the presence of edta and ferrous ion was about 80% that seen in rat liver microsomes. from these results, it is likely that low lipid peroxidation activity in rabbit liver microsomes may account for the insuffic ... | 1977 | 22771 |
| characterization of exchange-labeled saxitoxin and the origin of linear uptake by excitable tissue. | | 1977 | 22807 |
| glutamate as transmitter of hippocampal perforant path. | | 1977 | 22816 |
| central nervous respiratory depressants--narcotic analgesics. | | 1977 | 22878 |
| pharmacologic effect of protracted neuroleptics, fluphenazine oenanthate and oxyprothepine oenanthate (vufb 9447). | two neuroleptica with protracted effect, i.e. fluphenazin-oenanthat and oxyprothepin-oenanthat, were tested on rats, dogs and rabbits. it was found that both drugs, after intramuscular injection in doses between 5--30 mg/kg, produced a long-lasting neuroleptic effect, in particular the inhibition of conditioned reflexes in rats, the antagonistic effect against apomorphine vomiting in dogs and the eeg-brain activity specific for neuroleptica. hardly any differences were found between the effects ... | 1975 | 22886 |
| properties of membrane-bound and soluble guanylate cyclase of cardiac and skeletal muscle. | kinetic properties of guanylate cyclase present in the washed particles, plasma membranes, and the soluble cytoplasm of heart and skeletal muscle are described; properties of the enzyme solubilized by triton x-100 treatment of the particles or membrane fractions are also reported. it is apparent from the data that the membrane-bound guanylate cyclase in the cell may be regulated by acetylcholine, may exist as a metallo-protein with bound mn2+ (essential for activity), and that mg2+ regulates, wh ... | 1976 | 22902 |
| ph and the effect of fluoride and zinc on protein and collagen biosynthesis in rabbit dental pulp in vitro. | the effect of ph in the range 6.6-8.2 on the incorporation of 14c-proline into the rabbit dental pulp incubated in vitro has been studied. the amount of label in the cold tca-soluble pool, total protein, and hydroxyproline (i.e. collagen) of the pulp tissue increased linearly with ph in all three fractions. a similar increase was found in the amount of labeled total protein and collagen recovered from the incubation medium. the results indicated that the uptake of 14c-proline into the tca-solubl ... | 1977 | 22925 |
| dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms. | dopamine and apomorphine produced concentration-dependent inhibition of adrenergic neurotransmission in the isolated, perfused, rabbit ear artery. the inhibitory action of both dopamine and apomorphine was competitively antagonized by haloperidol and several other antipsychotic drugs. the calculated affinities of these drugs for the dopaminergic receptor correlate closely with both the pharmacological potencies of these drugs in vivo and their reported potencies as inhibitors of 3hhaloperidol bi ... | 1978 | 22933 |
| some properties of the lipoxygenase from rabbit reticulocytes. | a lipoxygenase was enriched from the stoma-free supernatant of rabbit reticulocytes. the enzyme causes drastic deterioration of mitochondrial membranes. the release of matrix enzymes is paralleled by formation of products of lipid peroxidation. the enzyme reacts with isolated phospholipds and free cis-unsaturated fatty acids. some properties were determined: molecular weight, isoelectric point, temperature and ph-dependence and km value for linoleic acid. the enzyme is inhibited by reaction prod ... | 1977 | 22967 |
| inactive renin--a renin proenzyme? | human plasma contains an inactive form of renin with a m.w. of 55,000, as against around 40,000 for active human renin. after acidification to ph 3.0 or incubation with trypsin, the inactive renin becomes more active and the molecular weight falls to that of active renin. in human kidney extracts, an increase in renin concentration also occurred after acidification. the inactive form of renin may be similar to that of rabbit kidneys, which contain an inactive renin that can be activated by remov ... | 1977 | 22995 |
| in vivo function tests of the effect of tilorone and niridazole on cell-mediated immunity in chickens. | the need for effective, safe, specific cellular immune suppression in avian research led to the study of effects of tilorone and niridazole on cell-mediated immunity of chickens. two in vivo tests for cell-mediated immunity function were used--the graft-vs-host (gvh) test and the delayed hypersensitivity (dh) test. humoral immunity was evaluated by measuring natural hemagglutination (ha) titers against rabbit red blood cells. intraperitoneal administration of tilorone to young chickens appeared ... | 1977 | 23063 |
| phosphorus nuclear magnetic resonance studies of phosphoglucomutase and its metal ion complexes. | | 1977 | 23074 |
| further evidence for gaba-ergic mechanisms in the action of benzodiazepines. | drugs of the benzodiazepine series (clonazepam, lorazepam, diazepam and medazepam) increase the inhibitory processes in the cerebral cortex as it has been shown by means of the recovery cycles of the intracortical response. there is a correlation between the effect on the recovery cycles and their protective action against convulsions induced by gaba deficit. diazepam enhances the inhibitory effect of gaba applied iontophoretically to rabbit sensorymotor cortex neurons. the drug gaba-ergic effec ... | 1977 | 23084 |
| central nervous actions of beta-adrenoreceptor antagonists. | | 1978 | 23236 |
| pulmonary carbonic anhydrase and the realse of carbon dioxide from the plasma. | | 1978 | 23259 |
| the ventilatory response to intravenous co2 loading. | | 1978 | 23260 |
| n-acetylation of drugs. a genetically controlled reciprocal relationship between drug n-acetylating enzymes of rabbit liver and peripheral blood cells. | the reciprocal relation between liver isoniazid n-acetyltransferase and blood p-aminobenzoic and n-acetyltransferase previously reported is confirmed and found to be expressed in erythrocytes and lymphocytes of genetically rapid and slow isoniazid-acetylator rabbits. both erythrocytes and lymphocytes from slow acetylator rabbits contained 2.5-3.3 times as much p-aminobenzoic acid n-acetyltransferase activity as the same cells from rapid acetylator rabbits. mechanisms which might account for the ... | 1978 | 23269 |
| excretion of phenytoin into semen of rabbits and man. comparison with plasma levels. | the concentration of phenytoin (diphenylhydantoin, dph) was measured in plasma and semen of rabbits and man. in the rabbit, a single iv injection of dph (4.64 mg) resulted in a concentration-time curve for dph in semen parallel to the concentration-time curve for dph in plasma (t1/2beta = 171 +/- 29 min). a semen/plasma drug concentration ratio of 0.20 was maintained for at least 8 hr, demonstrating that dph concentrations in semen are directly proportional to dph concentrations in plasma. in ep ... | 1978 | 23276 |
| disposition of primidone, phenylethylmalonamide, and phenobarbital in the rabbit. | | 1978 | 23277 |
| age-dependent renal accumulation of cephaloridine in the rabbit. | the accumulation of cephaloridine in the renal cortex of the rabbit was studied in vitro and in vivo in rabbits of various ages. the cortical concentration of cephaloridine, the cortex/serum ratio, and the slice/medium ratio determined by incubation of cortical slices in cephaloridine-containing media rose from birth to adult levels at approximately 1 month of age. pretreatment with procaine penicillin g stimulated the ability to accumulate cephaloridine in vitro and in vivo. the data indicate t ... | 1978 | 23280 |
| the interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues. | addition of ruthenium red to mitochondria isolated from brain, adrenal cortex, parotid gland and skeletal muscle inhibits further uptake of ca2+ by these mitochondria but induces little or no net ca2+ efflux; the further addition of na+, however, induces rapid efflux of ca2+. the velocity of the na+-induced efflux of ca2+ from these mitochondria exhibits a sigmoidal dependence on the na+. addition of na+ to mitochondria exhibiting the most active na+-dependent efflux of ca2+ (brain and adrenal c ... | 1978 | 23291 |
| the third thudichum lecture: some incidents in the search for chemical transmitters in the brain. | | 1977 | 23332 |
| ditazole activity and its interaction with urokinase on experimental thrombosis. | the effect of ditazole, a new antiaggregant oxazole derivative as well as its possible interaction with urokinase on the formation of electrically induced thrombus, was assayed in rabbits. the activity of ditazole in reducing thrombus weight was comparable to that of aspirin. in the ditazole- or aspirin-treated animals, the microscopical examination of the thrombus showed a reduction in the fibrin component, and well-isolated platelets not undergoing a viscous metamorphosis were present. urokina ... | 1977 | 23345 |
| isolation and characterization of a phospholipase a2 from an inflammatory exudate. | sterile peritoneal exudates produced in rabbits injected with 1% glycogen contain a phospholipase a activity in a cell-free supernatant fraction that hydrolyzed a synthetic phospholipid (1,2-diacyl-sn-glycero-3-phospho-ethanolamine) and phospholipids of autoclaved escherichia coli. this phospholipase activity (phosphatidylacylhydrolase ec 3.1.1.4) exhibited an apparent bimodal ph optimum (ph 6.0 and ph 7.5) and was ca(2+)-dependent; mg(2+) and monovalent cations (na(+) and k(+)) did not substitu ... | 1978 | 23403 |
| further evidence for adrenergic transmission in the human vas deferens. | 1. isolated portions of human vas deferens responded to field stimulation of the intramural nerve fibres or to exogenously applied noradrenaline with rhythmical contractions of both longitudinal and circular muscle layers. 2. in guinea-pig and rabbit vas deferens field stimulation produced an initial rapid 'twitch' response which was not found with human vasa. 3. responses of the human vas to field stimulation were depressed by the alpha-adrenoceptor blocking agents phentolamine and yohimbine. 4 ... | 1977 | 23430 |
| effects of disodium cromoglycate and antihistamines in acute serum sickness of rabbits. | | 1977 | 23528 |
| molecular mechanism of active calcium transport by sarcoplasmic reticulum. | | 1978 | 23557 |
| h+ transport: regulation and mechanism in gastric mucosa and membrane vesicles. | | 1978 | 23558 |
| antigenicity of a spontaneous murine mammary adenocarcinoma during in vitro cultivation. | | 1977 | 23597 |
| comparative metabolism of benorylate and an equivalent mixture of aspirin and paracetamol in neonate and adult rabbits. | 1. benorylate was well absorbed in rabbits, but more slowly than an equimolar mixture of aspirin and paracetamol. 2. benorylate was extensively hydrolysed and converted to the typical metabolites of aspirin and paracetamol by both neonate and mature rabbits. 3. absorption of either aspirin-paracetamol or benorylate was slower in neonate rabbits than in adult rabbits. 4. the excretion rate in adult rabbits was faster, for both aspirin and paracetamol metabolites, than in neonate rabbits. | 1977 | 23612 |
| autoantibodies in sera of rabbits immunized with influenza virus. | rabbits immunized with purified influenza a (h3n2) virus within 4 weeks developed autoantibodies of sma type (smooth muscle antibodies). in some of them also abba (antibodies against brush border of proximal renal tubuli) and ana (anti-nuclear antibodies) were detected. this autoimmune response was found to be unrelated to either the virus dose or the adjuvant used for immunization. autoantibodies were not parallel in titre with influenza antibody. | 1977 | 23669 |
| alpha adrenergic regulation of the vascular and aqueous humor microcirculation of the chamber angle. | | 1977 | 23757 |
| proteoglycan-degrading enzymes. a radiochemical assay method and the detection of a new enzyme cathepsin f. | 1. polyacrylamide beads containing entrapped 35s-labelled proteoglycan molecules have been prepared. 2. the measurement of release of radioactivity provides an extremely sensitive assay for proteoglycan-degrading enzymes, including proteinases and hyaluronidase. 3. the amount of label released is a logarithmic function of enzyme concentration or time of incubation. experiments were made in an attempt to explain this. 4. assays were made by the new method at several ph values, and with the inclus ... | 1977 | 23763 |
| degradation of myofibrillar proteins by cathepsins b and d. | 1. the procedure of barrett (1973) biochem. j.131, 809-822 for isolating cathepsins b and d from human liver was modified for use with rat liver and skeletal muscle. the purified enzymes appeared to be similar to those reported in other species. 2. sephadex g-75 chromatography of concentrated muscle extract resolved two peaks of cathepsin b inhibitory activity, corresponding to molecular weights of 12500 and 62000. 3. the degradation of purified myofibrillar proteins by cathepsins b and d was cl ... | 1977 | 23766 |
| plasma dopamine beta-hydroxylase species dependence and in the vitro influence of nem, coppor, and ph. | | 1978 | 23770 |
| translation of tyrosine aminotransferase mrna in a modified reticulocyte system. | | 1977 | 23773 |
| 15n nmr studies of the binding of 15n-labeled cyanide to various hemoglobins in intact erythrocyte. | | 1978 | 23781 |
| beta-adrenoceptor blockade with diphenylhydantoin (dph). | diphenylhydantoin (dph) (20 x 10(-6) to 80 x 10(-6) m/kg) blocked the depressor responses to isoproterenol in spinal, bilaterally vagotomized and atropine pretreated cats; depressor responses to histamine were unaffected; dph shifted the isoproterenol concentration-response curve to the right in isolated guinea pig tracheal chain preparation, isolated rabbit ileum and isolated perfused heart of frog. the results suggest that dph has a specific beta-adrenoceptor blocking action and the blockade a ... | 1977 | 23797 |
| experiments in animals on the pharmacological effects of metipranolol in comparison with propranolol and pindolol. | the beta-blocking agent 1-(4-acetoxy-2,3,5-trimethylphenyloxy)-3-isopropylamino-propan-2-ol (metipranolol) was compared with propranolol and pindolol. the beta-blocking activity on isoproterenol induced tachycardia was determined in rabbits (ed250bpm). the following doses in microgram/kg i.v. were required to produce the same inhibition: 410 propranolol; 160 metipranolol; 130 pindolol. when intrinsic sympathomimetic activity was determined in reserpinized rats metipranolol was found to produce l ... | 1977 | 23798 |
| purification and properties of a cyclic amp-independent protein kinase from calf thymus nuclei. | a phosphoprotein kinase (atp : protein phosphotransferase, ec 2.7.1.37) from calf thymus nuclei was purified by deae-cellulose chromatography, hydroxyapatite, and sepharose 6b gel filtration. the enzyme is a cyclic amp-independent protein kinase by the following criteria: (a) the protein kinase did not bind cyclic amp; (b) no inhibition of activity was obtained with the heat-stable protein kinase inhibitor from rabbit skeletal muscle; (c) the regulatory subunit of cyclic amp-dependent protein ki ... | 1978 | 23835 |
| studies on (na+ + k+)-activated atpase. xlii. evidence for two classes of essential sulfhydryl groups. | 1. preincubation of purified (na+ + k+)-atpase (atp phosphohydrolase, ec 3.6.1.3) preparations from rabbit kidney outer medulla with 5,5'-dithiobis-(2-nitrobenzoic acid) inhibits the (na+ + 5+)-atpase and k+-stimulated 4-nitro-phenylphosphatase activities. phosphorylation of the enzyme by atp and the na+-stimulated atpase activity are inhibited to the same extent as the (na+ + k+)-atpase activity, whereas the k+-stimulated 4-nitrophenylphosphatase activity is inhibited much less. 2. titration wi ... | 1978 | 23852 |
| differences between human and rabbit transferrins. | rabbit reticulocyte incorporation of iron from rabbit transferrin was independent of transferrin iron saturation but uptake from human transferrin was saturation dependent. unlike human transferrin, rabbit transferrin does not surrender its iron from any unique preferred iron-binding site and can be described as functionally homogeneic. the two proteins also differ in their acid-base iron-binding properties. one human transferrin iron binding site retains an ability to bind iron at somewhat acid ... | 1978 | 23866 |
| responses of rabbit portal vein to histamine. | 1 histamine produced a dose-dependent contraction of the isolated portal vein of the rabbit. this contraction was not antagonized by atropine, methysergide, indomethacin, cocaine or 6-hydroxy-dopamine, nor by pretreatment of the rabbit with reserpine. 2 the response to histamine was blocked by h1-receptor antagonists only when the blocking agent was used in very high concentrations, and was not antagonized by the h2-receptor blocking agent, metiamide, h1-receptor antagonists did not block the ef ... | 1978 | 23880 |
| a radioautographic study of the neuroepithelial bodies of the lungs in fetal and neonatal rabbits. | the neuroepithelial bodies (neb's) of the lung of 29-day-old fetuses and 1-day-old rabbits, under the conditions of this study, neither take up 3h-thymidine nor undergo mitosis. also the neb's are not derived at these times from proliferations of other kinds of epithelial cells in the intrapulmonary airways. it is, therefore, suggested that the difference in numbers of neb's previously observed by us, between the 29-day fetus and the 1-day-old rabbit, is due either to regranulation or acquisitio ... | 1978 | 23904 |