| experiments on the preparations and testing of associated vaccine against foot and mouth disease and vesicular disease in swine. | tests for associated immunization of swine against foot and mouth disease (fmd) and vesicular disease (svd) of swine were carried out. as a result of this investigation, it was established that the prepared and tested inactivated oil vaccine is harmless and immunogenic in sensitive animals. in investigating the course of immunity, the presence of antibody against both antigens was demonstrated in vaccinated animals. all once-vaccinated animals were defended against the virus of svd during challe ... | 1978 | 27158 |
| blood acid-base status in fattening pigs in exhausting physical stress of high intensity. | reported in this paper are changes in the acid-base state and lactic concentration of blood and muscle samples taken from 28 pigs prior to, during, and after high-intensity exhausting stress applied at ambient temperatures between 17 degrees c and 21 degrees c and at 35 degrees c. close correlations were found to exist between acid-base states, on the one hand, and lactic acid concentrations, on the other. the lactic acid concentrations reached in blood plasma were between 30 and 40 mhol/1, ph b ... | 1978 | 27161 |
| effects of con a and other lectins on pure 5'nucleotidase isolated from lymphocyte plasma membranes. | | 1978 | 27195 |
| gastric secretion in suckling pigs and early-weaned pigs given a dry cow's-mild formula ad lib. | 1. twelve gastric-cannulated litter-mate pigs were used to study secretion and proteolytic activity in the stomach of suckling and early-weaned pigs in relation to age and food intake. 2. results demonstrate that from the first observation at day 8, piglets were able to secrete acid. ph and acid concentration did not change during the first 4 weeks of life. 3. proteolytic activity was low during the first 2--3 weeks of life and rapidly increased thereafter. 4. two phenomena differentiated suckli ... | 1978 | 27207 |
| transglutaminase-catalyzed insertion of a fluorescent probe into the protease-sensitive region of rhodopsin. | | 1978 | 27209 |
| release of slow-reacting substance from guinea-pig and human lung by calcium ionophore a23187 proceedings. | | 1978 | 27275 |
| evidence for the participation of beta1-adrenoceptors in isoprenaline-induced renin release from rat kidny slices in vitro. | 1. the inhibitory effects were studied of 4 beta-adrenoceptor antagonists against renin release induced by isoprenaline (0.5 mumol/1) in rat kidney slices. additionally the pa2 values of these 4 drugs were measured against isoprenaline in guinea-pig isolated atria and trachea (against beta1- and beta2-adrenoceptors respectively). 2 when employed at a concentration of 2 mumol/1 propranolol and atenolol significantly inhibited renin release (p less than 0.001 and p less than 0.01) whereas practolo ... | 1978 | 27279 |
| synthesis and adrenergic beta-blocking activity of some propanolamine derivatives. | | 1978 | 27307 |
| the "m" cell. a special effector cell system for rejection of hematopoietic grafts. | | 1978 | 27336 |
| effects on enzyme activity of ligand-binding to copper in pig-plasma benzylamine oxidase. | | 1978 | 27352 |
| the 3hcolchicine-binding properties of platelet tubulin. | | 1978 | 27407 |
| the transport of nitrite in the blood proceedings. | | 1978 | 27410 |
| species differences in the in vitro metabolic reduction of the amphetamine metabolite, 1-phenyl-2-propanone. | marked differences were observed, in the ability of fortified 9000 g liver homogenate supernatants from three species to reduce 1-phenyl-2-propanone to the corresponding alcohol. this metabolic keto-reduction was negligible in homogenates from the rat and extensive in the rabbit; guinea-pig liver homogenates had intermediate ability. metabolic oxidation of 1-phenyl-2-propanol was negligible in all three species. the amount of deamination of amphetamine and of n-n-propylamphetamine was approximat ... | 1978 | 27606 |
| effectiveness of pyridostigmine in reversing neuromuscular blockade produced by soman. | the effects of pyridostigmine pretreatment on the neuromuscular blockade produced by soman in anaesthetized, atropinized animals have been studied on the soleus and anterior tibialis muscle (rhesus monkeys, cats and rabbits) and the gastrocnemius muscle (guinea-pigs and rats). pyridostigmine pretreatment produced a complete recovery of neuromuscular function following blockade by soman; the rate of recovery was similar in all the species, suggesting a common mechanism of action. in the absence o ... | 1978 | 27607 |
| comparison of the cardiotoxic effects of carbromal, bromisoval and pentobarbital. | | 1978 | 27695 |
| restorative effect of histamine on the transmembrane action potentials in potassium-depolarized guinea-pig auricle. | | 1978 | 27771 |
| role of the adrenals and their interaction with the thymus in regulating the tissue incompatibility response. | | 1978 | 27912 |
| glycosidases of the arterial wall. | | 1977 | 27963 |
| khasan virus, a new ungrouped bunyavirus isolated from haemaphysalis longicornis ticks in the primorie region. | strain leiv-776p, possessing no haemagglutinating activity was isolated in 1971 in the primorie region (u.s.s.r.) from haemaphysalis longicornis neumann 1091 tick. complement fixation (cf) tests revealed no antigenic relationship with 24 antigenic groups of arboviruses or 21 ungrouped viruses isolated from ticks. the virus isolate contains rna and is relatively sensitive to ether and sodium deoxycholate; it is pathogenic for suckling mice and two-week-old white mice by the intracerebral route, a ... | 1978 | 27977 |
| a rapid sensitive assay for phosphatidate phosphohydrolase. | | 1978 | 27995 |
| preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound. | oxatomide or r 35443, 1-(3-4-(diphenylmethyl)-1-piperazinylpropyl)-1,3-dihydro--2h-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal arteries of the rat. in vivo it is a powerful antagonist of bronchospasm induced by serotonin and by histamine; it has no anticholinergic effects and does not affect blood pressure in spontaneously hypertensive rats. these antiserotonin properties of oxatomide may cont ... | 1978 | 28094 |
| specific and aspecific activity of an antihistaminic of the h1 type: hc 20-511 or ketothiphen (benzo-cyclohepta-thiophenone derivative). | | 1977 | 28130 |
| the opiate receptors and the discovery of opioid-like peptides. | | 1978 | 28218 |
| purification and properties of 5'-nucleotidase from lymphocyte plasma membranes. | 5'-nucleotidase is purified from lymphocyte plasma membranes by two affinity chromatographies. the first one, on lens culinaris lectin-sepharose 4b yields a fraction of twelve lectin-binding glycoproteins (lectin-receptor fraction). the second one on 5'-amp-sepharose 4b leads to pure enzyme. this enzyme is a glycoprotein with a molecular weight of 130 000; it gives a single band in polyacrylamide/dodecylsulfate electrophoresis and displays a very high specific activity (2500-3000 mumol pih-1mg-1 ... | 1978 | 28225 |
| alpha-tocopherol: uses in preventing nitrosamine formation. | alpha-tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. the use of alpha-tocopherol was shown to inhibit aminopyrene-nitrite induced hepatotoxicity in rats and to reduce the amount of ndma formed in cigarette smoke. of primary interest is the finding of a significant reduction of npyr formation in ... | 1978 | 28277 |
| stereospecific side chain hydroxylations in the biosynthesis of chenodeoxycholic acid. | | 1978 | 28327 |
| an improved assay of tyrosine hydroxylase using sodium activation. | | 1978 | 28386 |
| the character of the antagonism by polyphloretin phosphate of contractions to prostaglandins e1 and f 2alpha in guinea-pig ileum. | polyphloretin phosphate (ppp) produced a dose-dependent decrease in the tone and reduction of the spontaneous phasic contactions of the longitudinal muscle of guinea-pig isolated ileum. ppp (100 microgram ml-1) after a 2 min contact with the ileum decreased the contractile effects of pge1 0.1 micron by 40.6 +/- 7.4%, of pge1 0.01 micron by 86.7 +/- 3.3% and of pge2alpha 0.1 micron by 62.2 +/- 8.6%. after 10 min contact of ppp the contractile effect of pge1 0.1 micron was decreased by 47.7 +/- 4. ... | 1978 | 28396 |
| narcotic antagonistic action of cimetidine on the guinea-pig ileum. | | 1978 | 28406 |
| an analysis of the inhibitory effects and of possible prostaglandin antagonism of steroid sex hormones in the guinea-pig ileum. | | 1978 | 28410 |
| effect of anions on inhibition of lactate dehydrogenase by pyruvate. | the effect of anions cl- and i- on structural and kinetic properties of ldh was investigated. it was shown that anions are specific inhibitors of ldh competing with pyruvate in the active ternary complex, ldhnadhpyq. the following dissociation constants for the anions were obtained from inhibition data: 0.4 +/- 0.02 and 0.07 +/- 0.01 m for cl- and i-, respectively. the slope of hill plot are near 1.0. the anions abolished the inhibition of ldh at high pyruvate concentrations. the following disso ... | 1978 | 28475 |
| alpha agonist and local anaesthetic properties of xylazine. | | 1978 | 28627 |
| structural requirements of imidazole compounds to be inhibitors or activators of histamine methyltransferase: investigation of histamine analogues and h2-receptor antagonists. | | 1978 | 28646 |
| the effect of chronic administration of digitoxin on the activity of the myocardial (na + k)-atpase in guinea-pigs. | when guinea-pigs were treated for 24 days with digitoxin 0.3 mg/kg s.c., the activity of the (na + k)-atpase of the heart muscle increased by about 30% compared to controls, whereas the enzymes prepared from kidney and brain showed no significant alteration in their activity. in animal species treated with digitoxin for 1 to 5 days, no increase of enzyme activity was observed. only after 10 to 15 days of treatment, a significant increase of the (na + k)-atpase activity was noted which increased ... | 1978 | 28701 |
| in vitro measurement of the beta-adrenergic blocking properties of orf 12592, the 5-hydroxy analog of propranolol. | orf 12592 caused concentration-dependent inhibition of isoproterenol stimulated adenylate cyclase activity in sarcolemma-enriched membrane preparations of guinea-pig myocardium. its potency was slightly less than that of d,l-propranolol. orf 12592 did not stimulate basal enzyme activity, suggesting it to be devoid of intrinsic sympathomimetic activity. it produced no marked inhibition of basal activity, nor did it inhibit sodium fluoride stimulated enzyme activity, indicating that the compound a ... | 1978 | 28704 |
| studies on the time-dependent response of the cardiac ca-mediated action potential due to variations of the external ca concentration. | | 1978 | 28724 |
| quantitation of hydrogen ion and potential gradients in gastric plasma membrane vesicles. | the atp-dependent uptake of h+ by hog gastric parietal cell vesicles was quantitated by using the ph indicator dyes bromcresol green and malachite green, the weak bases, aminopyrine and 9-aminoacridine, and the ph electrode. a k+-dependent h+ uptake was found, with a significant difference between the quantity of h+ disappearing from the medium (deltaho) and the quantity appearing inside the vesicle (deltahi). 9-aminoacridine gave a lower value for the deltahi than any of the other probes. probe ... | 1978 | 28748 |
| nmr and enzymatic investigation of the interaction between elastase and sodium trifluoroacetate. | at ph 5.5, sodium trifluoroacetate is a potent competitive inhibitor of porcine elastase (ki = 2.6 mm) and human leukocyte elastase (ki = 9.3 mm). for both enzymes the ki increases strongly with ph. sodium fluoride is inactive on pancreatic elastase and sodium acetate is a weak inhibitor of this enzyme. trifluoroethanol inhibits both enzymes but is less active than trifluoroacetate in acidic ph conditions. bovine trypsin and alpha-chymotrypsin are resistant to the action of sodium trifluoroaceta ... | 1978 | 28776 |
| purification and properties of pig brain guanine deaminase. | guanine deaminase (guanine aminohydrolase, ec 3.5.4.3) from pig brain was purified to homogeneity by column chromatography and ammonium sulphate fractionation. homogeneity was established by polyacrylamide gel electrophoresis in the presence and absence of sodium dodecyl sulphate (sds). the molecular weight of 110 000 was determined by gel filtration and sucrose density gradient centrifugation. sds polyacrylamide gel electrophoresis indicated subunits of a molecular weight of 50 000. the amino a ... | 1978 | 28777 |
| early deviations of testicular leydig cells in the naturally unilateral cryptorchid pig. | | 1978 | 28792 |
| experimental studies on alpha receptor blockaders--effects on catecholamine secretion by the adrenal medulla. | | 1978 | 28862 |
| preparation and long-term cultivation of porcine tracheal and lung organ cultures by alternate exposure to gaseous and liquid medium phases. | conventional methods of organ culture have proved unsatisfactory for mammalian lung because of the rapid collapse of the tissue and the loss of its normal structure. in an effort to circumvent this problem and to provide a means for visualizing the cellular relationships throughout the culture period, respiratory organs consisting of trachea and lungs of fetal or hysterectomy-derived 1- to 4-week-old pigs were embedded in warm 3% noble agar in phosphate buffer silicone solution and cooled to fir ... | 1978 | 29005 |
| the internal ph of isolated serotonin containing granules of pig platelets. | the 14cmethylamine distribution method was utilized to measure the internal ph of isolated serotonin containing granules of pig blood platelets under varying conditions. the granules used were isolated by a new protocol which stressed platelet rupture under controlled conditions and preservation of isotonicity throughout the isolation procedure, in a well buffered external medium, ph 6.85, the deltaph was measured as 1.11 with the internal ph being found acidic (ph 5.74). increasing the external ... | 1978 | 29047 |
| occurrence of idiotypically identical antibodies in the sera of two outbred rabbits hyperimmunized with type ii pneumococcal vaccine. | | 1978 | 29067 |
| the effects of some analgesic and neuroleptic drugs on the spasmogenic actions of substance p on guinea-pig ileum. | | 1978 | 29099 |
| effects of morphine on non-adrenergic inhibitory responses of the guinea-pig taenia coli. | | 1978 | 29108 |
| initiation of the respiratory burst in human polymorphonuclear neutrophils: a critical review. | | 1978 | 29122 |
| cardiac electrophysiology of four neuroleptics: melperone, haloperidol, thioridazine and chlorpromazine. | | 1978 | 29233 |
| the effect of puromycin on tyrosine hydroxylase activation in the vas deferens following nerve stimulation. | | 1978 | 29304 |
| the effects of alpha- and beta-adrenergic agonists upon depolarization induced ventricular automaticity. | | 1978 | 29312 |
| a study of the nematocyst venoms of the sea anemone, bolocera tuediae. | | 1978 | 29365 |
| brain dopamine metabolism and behavioral problems of farm animals. | | 1978 | 29448 |
| influence of mild acid hydrolysis on the antigenic properties of phase i coxiella burnetii. | mild acid hydrolysis of phase i coxiella burnetii cells gradually cleaved off polysaccharide chains, which contain determinants of antigen 1, thus unmasking determinants of the diagnostically important antigen 2. this artificial phase i to phase ii conversion was reflected by changed serological activity in the complement-fixation (cf) test and by changed nonspecific phagocytosis. the product of mild acid hydrolysis can serve as a complex diagnostic preparation, because it reacts in the cf test ... | 1978 | 29469 |
| biologic activities of beta-endorphin and its related peptides. | | 1977 | 29548 |
| malate dehydrogenase of the cytosol. ionizations of the enzyme-reduced-coenzyme complex and a comparison with lactate dehydrogenase. | 1. the ph-dependencies of the binding of nadh and reduced nicotinamide--benzimidazole dinucleotide to pig heart cytoplasmic malate dehydrogenase and lactate dehydrogenase are reported. 2. two ionizing groups were observed in the binding of both reduced coenzymes to lactate dehydrogenase. one group, with pka in the range 6.3--6.7, is the active-site histidine residue and its deprotonation weakens binding of reduced coenzyme 3-fold. binding of both coenzymes is decreased to zero when a second grou ... | 1978 | 29604 |
| the relation of the ph and concentration-dependent dissociation of porcine heart mitochondrial malate dehydrogenase. | | 1978 | 29613 |
| nadp+-linked malic enzymes from pig heart mitochondria--apparent selective inhibition of one enzyme form. | | 1978 | 29618 |
| the alpha adrenergic receptor mediated increase in guinea-pig liver glycogenolysis. | | 1978 | 29649 |
| metabolism of lergotrile to 13-hydroxy lergotrile, a potent inhibitor of prolactin release in vitro. | | 1978 | 29651 |
| comparison of tyrosine hydroxylase and choline acetyltransferase activity in response to sympathetic nervous system activation. | | 1978 | 29696 |
| the ph-dependent recovery of smooth muscle from storage at -13 degrees c in unfrozen media. | | 1978 | 29743 |
| the denaturation of covalently inhibited swine pepsin. | studies are reported on the denaturation of freshly prepared, intact swine pepsin, which was inactivated by reaction with diazoacetylglycine ethyl ester, to prevent autolysis. denaturation about ph 6 was found to involve a small expansion of the molecular domain with some loss of organized secondary structure. on the other hand, increasing concentrations of guanidine hydrochloride induced cooperative transitions in both the native and alkali denatured forms to give a cross-linked random coil. no ... | 1978 | 29843 |
| multiple attack in porcine pancreatic alpha-amylase-catalyzed hydrolysis of amylose studied with a fluorescence probe. | 1. a large fluorescence enhancement of 2-p-toluidinylnaphthalene-6-sulfonate (tns) observed in the presence of amylose was utilized to monitor quantitatively the time course of porcine pancreatic alpha-amylase ec 3.2.1.1 (ppa)-catalyzed hydrolysis of amylose with a number-average degree of polymerization of 16.8. 2. the slope of the plot of decrease in the relative fluorescence intensity of the tns-amylose system (termed as the fluorescence value) versus the number of linkages hydrolyzed (reduci ... | 1978 | 29891 |
| activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides. | purified prostaglandin endoperoxides (pgg2 and pgh2) and hydroperoxides (15-ooh-pge2) as well as fatty acid hydroperoxides (12-ooh-20:4, 15-00h-20:4, and 13-ooh-18:2) were examined as effectors of soluble splenic cell guanylate cyclase activity. the procedures described (in the miniprint supplement) for the preparation, purification, and characterization of these components circumvented the use of diethyl ether which obscured effects of lipid effectors because of contaminants presumed to be ethe ... | 1978 | 29900 |
| effect of ph on the uptake and efflux of calcium from cardiac sarcoplasmic reticulum vesicles proceedings. | | 1978 | 29964 |
| coated vesicles: characterization, selective dissociation, and reassembly. | sodium dodecyl sulfate/polyacrylamide gels of coated vesicles from porcine brain (mean 76% coated vesicles) show three major proteins (180,000, 125,000, and 55,000 daltons) that account for 73% of the total protein. preparations consisting predominantly of coats (65%) have less of the 55,000-dalton protein. clathrin (180,000 daltons) comprises 40% of the protein of a coated vesicle. conditions of 2 m urea, 0.25 m mgcl2, or ph 7.5 disrupt the coat and solubilize clathrin. solubilized clathrin ref ... | 1978 | 30086 |
| the role of pterin cofactor in the regulation of catecholamine synthesis. | | 1978 | 30112 |
| application of the sousa (john phillip) principles to medical research: the role of cyclic nucleotides in hormone and drug action. | | 1978 | 30205 |
| effect of increasing tuberculin doses on the immunological reactivity of sensitized animals. | | 1978 | 30230 |
| treatment of ischemic ulcers of geriatric patients with sterile frozen pigskin dressing proceedings. | | 1978 | 30306 |
| inactivation of pig heart alanine aminotransferase by beta-chloroalanine. | | 1978 | 30393 |
| activation of kidney guanylate cyclase by cobalt. | | 1978 | 30396 |
| characterization of an agglutinin from human serum. | after exposure to serum, an agglutination of mitochondria from yeast, liver, heart and kidney was observed. the degree of agglutination was dependent on the ratio between the amount of serum proteins and mitochondrial protein. the serum protein which induced agglutination was bound irreversibly to the mitochondria, was heat stable and partly resistant to acidification. maximal agglutination was observed at an ionic strength equal to 40 mm tris, at ph 6.0-7.5. preincubation of mitochondria with c ... | 1978 | 30491 |
| occurrence of h1- and h2-histamine receptors in the guinea-pig gall bladder in situ. | 1 histamine has a dual action on the in situ gall bladder of the guinea-pig: a spasmogenic and a relaxant effect mediated through h1- and h2-receptor stimulation respectively. 2 the contracturant action, mimicked by 2-(2-aminoethyl) thiazole (a specific h1-receptor agonist), is blocked by mepyramine and the relaxation, mimicked by dimaprit (a specific h2-receptor agonist), is inhibited by cimetidine. | 1978 | 30504 |
| pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum. | 1 the presynaptic alpha-adrenoceptors located on the terminals of the cholinergic nerves of the guineapig myenteric plexus have been characterized according to their sensitivities to alpha-adrenoceptor agonists and antagonists.2 electrical stimulation of the cholinergic nerves supplying the longitudinal muscle of the guinea-pig ileum caused a twitch response. clonidine caused a concentration-dependent inhibition of the twitch response; the maximum inhibition obtained was 80 to 95% of the twitch ... | 1978 | 30507 |
| effects of orally ingested histamine and/or commercially canned spoiled skipjack tuna on pigs, cats, dogs and rabbits. | | 1978 | 30573 |
| metabolism of aniline in rats, pigs and sheep. | | 1978 | 30604 |
| assay of hexobarbital hydroxylase. | | 1978 | 30612 |
| purification and properties of hexoasmine isomerase (ec5.3.1.19) from pig intestinal mucosa. | hexosamine isomerase from pig intestinal mucosa was purified about 70-fold. the aminosugar product of the enzymatic reaction was identified as glucosamine 6-phosphate and amino acid product as glutamic acid. the ph optimum was 7.1 km for fructose 6-phosphate was 6.3 x 10(-4) mol/1 and for l-glutamine 6.5 x 10(-4) mol/1. | 1978 | 30620 |
| histidine in the nucleotide-binding site of nadp-linked isocitrate dehydrogenase from pig heart. | incubation of pig heart nadp-dependent isocitrate dehydrogenase with ethoxyformic anhydride (diethylpyrocarbonate) at ph 6.2 results in a 9-fold greater rate of loss of dehydrogenase than of oxalosuccinate decarboxylase activity. the rate constants for loss of dehydrogenase and decarboxylase activities depend on the basic form of ionizable groups with pk values of 5.67 and 7.05, respectively, suggesting that inactivation of the two catalytic functions results from reaction with different amino a ... | 1978 | 30632 |
| plasma hypoxanthine levels in pigs during acute hypoxemia. a correlation between lactate and base deficit concentrations. | tissue hypoxia was induced in pigs by artificial ventilation with 6% o2 in n2 for 18 min. base deficit, lactate and hypoxanthine increased linearily during this period, and were significantly higher than initial values in the course of 6 min of hypoxemia. high correlation coefficients between hypoxanthine and lactate (mean 0.98) and between hypoxanthine and base deficit (mean 0.98) were found. during the recovery period when the animals were ventilated with air, high correlation coefficients bet ... | 1978 | 30633 |
| fundamental physiology of coronary smooth musculature from extramural stem arteries of pigs and rabbits. (electric excitability, tension development, influence of ca, mg, h and k ions). | | 1978 | 30634 |
| comparative metabolism of lorazepam in man and four animal species. | the metabolic disposition of lorazepam (wy-4036) in man, dog, cat, rat and miniature swine is compared. except in the cat, absorption of lorazepam is rapid in these species. absorption in humans is nearly complete. lorazepam glucuronide is the major metabolite in all species except the rat in which a dihydrodiol derivative is the main product of lorazepam biotransformation. lorazepam glucuronide, which has no demonstrable cns activity, is also present in the plasma of all species investigated. t ... | 1978 | 30761 |
| changes in dopamine-dependent motor behaviour caused by propranolol and its isomers. | | 1978 | 30826 |
| effect of an h-2 antagonist on gallbladder contraction. | | 1978 | 30862 |
| an assessment of parameters in quasar studies of narcotic analgesics and antagonists. | | 1978 | 30912 |
| [intrinsic sympathomimetic activity of beta-blockers]. | | 1978 | 30947 |
| kainic acid injections result in degeneration of cochlear nucleus cells innervated by the auditory nerve. | when kainic acid, a putative neurotoxin for neurons with glutamatergic input, is injected into the brainstem, it produces a selective pattern of degeneration in the cochlear nucleus. the rate and extent of degeneration is correlated with the distribution of the primary auditory fibers. this evidence supports the hypothesis that glutamate is the neurotransmitter for primary auditory fibers. | 1978 | 31000 |
| differential effect on the sympathetic transmitter level in uterus and other organs of guinea-pig by drugs interfering with adrenergic nerve functions. | 5 types of adrenergic blocking agents with different modes of action were administered and the rate of transmitter depletion was studied in different uterine regions of guinea-pig, and compared with that in the heart and submandibular gland by a combination of fluorescence histochemical and spectrofluorimetric methods. the tyrosine-hydroxylase inhibitor, h 44/68, as well as reserpine and guanethidine, produced a more efficient reduction in neuronal noradrenaline in the heart and submandibular gl ... | 1978 | 31060 |
| phosphopyridoxal cyclic compounds with histamine and histidine. 7: the properties of pyridoxal and phosphopyridoxal cyclic compounds with histamine and histidine. | cyclic compounds synthesized from histamine (hi) or histidine (his) with pyridoxal (pl)--[hi-pl, his-pl] and hi or his with pyridoxal 5'-phosphate (plp)--[hi-plp, his-plp] were tested for stability in buffer, acid and base solutions, crude homogenates of various tissues and in the presence of enzymes which metabolize hi or his. the cyclic pyridoxal compounds were stable in all experimental conditions, whereas phosphopyridoxal cyclic products were degraded by rat intestinal dao and rat intestine ... | 1978 | 31076 |
| anti-inflammatory drug actions on allergic responses in guinea-pig skin. | five non-steroidal anti-inflammatory drugs (indomethacin, naproxen, meclofenamic acid, feprazone and phenylbutazone: nsaids) and three glucocorticosteroids (dexamethasone, hydrocortisone and prednisolone) have been tested as local inhibitors of increased vascular permeability in guinea-pig skin. lesions were induced by histamine or by antigen to evoke type i (passive cutaneous anaphylaxis), type iii (reverse passive arthus) and type iv (delayed hypersensitivity) allergic reactions. nsaids and gl ... | 1978 | 31078 |
| the effects of fractions (chalones) obtained from lymphoid organs on the immune response in vivo. | aqueous extracts of calf and pig lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing. these fractions, which had been previously assessed on mitogen-stimulated mouse spleen lymphocytes and other cells in vitro, were tested for their in vivo activity on humoral (haemolytic pfc in mice) and on cell-mediated immunity (skin allograft survival in mice, lymph node weight assay in rats, and systemic gvh-reaction in mice). none ... | 1978 | 31079 |
| progesterone: its role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release. | | 1977 | 31125 |
| beta-adrenoceptor agonist stimulation of acid secretion in rat isolated stomach [proceedings]. | | 1978 | 31221 |
| the effects of alpha- and beta-adrenoceptor agonists on inflammatory exudation in rabbit and guinea-pig skin [proceedings]. | | 1978 | 31224 |
| enzymatic formation of udp-n-acetylgalactosamine in epiphysial-plate cartilage. | the activity of udp-n-acetylglucosamine 4'-epimerase (ec 5.1.3.7) from newborn pig epiphysial-plate cartilage was investigated. the formation of radioactive udp-n-acetylgalactosamine from udp-n-acetyl[u-14c]-glucosamine was demonstrated by radioautography, after hydrolysis of udp-derivatives and separation of the hexosamines by paper chromatography. the ph optimum and the km values for udp-n-acetylglucosamine and nad were determined. at equilibrium, the ratio udp-n-acetylglucosamine/udp-n-acetyl ... | 1978 | 31263 |
| stimulation of arachidonic acid metabolism by human slow-reacting substances. | human slow-reacting substance of anaphylaxis (srs-a) and calcium ionophore-induced human srs released prostaglandin-like substances and rabbit aorta contracting substance (rcs) from guinea-pig lungs. this effect was abolished by incubation of srs-a and srs with arylsulphatase or pretreatment of the lungs with indomethacin. human srs-a and srs therefore resembled guinea-pig srs-a in stimulating arachidonic acid metabolism. these results provide further evidence for a similar (or identical) nature ... | 1978 | 31288 |
| studies on the mosquitoes of bankura district, west bengal: adult populations. | | 1978 | 31333 |
| [report of the conference for inner ear biology, bordeaux 1977 (author's transl)]. | | 1978 | 31340 |
| dopamine antagonistic effects of a series of analogues of oxiperomide and spiroxatrine measured behaviourally in the rodent. | the activity spectra of oxiperomide, spiroxatrine and analogues were determined in two experimental models of abnormal peri-oral movements (induced by intrastriatal dopamine and subcutaneously administered 2-(nn-dipropyl)amino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (nn-dipr-5,6-diohatn) in the guinea-pig), and in a stereotypy test (induced by subcutaneous apomorphine in the guinea-pig); the ability of the test compounds to induce catalepsy or catatonia in the rat was also determined. the pa ... | 1978 | 31432 |