| clindamycin treatment of mandibular osteomyelitis in a cynomolgus monkey. | | 1991 | 1962392 |
| the pharmacological properties of the imidazobenzodiazepine, fg 8205, a novel partial agonist at the benzodiazepine receptor. | 1. the pharmacological properties of the benzodiazepine receptor ligand, fg 8205 (7-chloro-5,6-dihydro-5-methyl-6-oxo-3-(5-isopropyl-1,2,4-oxadiazol++ +-3-yl)-4h- imidazol[1,5a][1,4]benzodiazepine) have been examined. 2. fg 8205 potently displaced [3h]-flumazenil binding in rat cortical membranes with a ki of 3.3 nm, but was inactive at 13 neurotransmitter recognition sites. 3. consistent with a partial agonist profile, the affinity of fg 8205 for the benzodiazepine recognition site was increase ... | 1990 | 1963808 |
| portal circulation in monkeys and humans studied after ingestion of a capsule containing a radionuclide. | capsules (8 x 30 mm) of technetium-99m pertechnetate were designed for measurement of portal blood flow. most of the radionuclide entered the superior mesenteric vein. the capsule was taken orally and monitored with a collimator for scintigraphy until it reached the small intestine, when a magnetic field completed an electrical circuit in a sensor, burning a thread, releasing a spring, and discharging the preparation. a study in crab-eating monkeys (macaca fascicularis) showed that the radionucl ... | 1990 | 1966480 |
| preliminary report: isolation of ebola virus from monkeys imported to usa. | an epizootic caused by an ebola-related filovirus and by simian haemorrhagic fever virus began among cynomolgus monkeys in a us quarantine facility after introduction of monkeys from the philippines. this incident, the first in which a filovirus has been isolated from non-human primates without deliberate infection, raises the possibility that cynomolgus monkeys could be a reservoir of ebola virus infection. | 1990 | 1968529 |
| dissociation between the effect of aceclidine on outflow facility and accommodation. | the dose/effect relationships for intracameral doses of aceclidine hcl and pilocarpine hcl on total facility of outflow and accommodative amplitude were compared in the cynomolgus monkey eye in vivo. the largest dose of aceclidine tested (20 micrograms), resulted in an average increase of 270% in outflow facility, whereas accommodation was limited to an average of 5 diopters. in contrast, 20 micrograms of intracameral pilocarpine (which is submaximal in increasing facility) resulted in an averag ... | 1990 | 1968849 |
| restriction fragment polymorphism of the cynomolgus monkey major histocompatibility complex. | among old world monkeys, the major histocompatibility complex (mhc) is defined only in the rhesus (macaca mulatta), cynomolgus (macaca fascicularis) and pigtailed (macaca nemistrina) species. however, little is known about the organization of class i and class ii mhc genes or the extent of polymorphism in macaques. in the present study, human and murine class i and class ii gene probes were used to analyze the leukocyte antigen (cyla) system of unrelated and related cynomolgus monkeys. restricti ... | 1990 | 1969744 |
| metabolism of temelastine (sk&f 93944) in hepatocytes from rat, dog, cynomolgus monkey and man. | a species comparison of the metabolic pathways of temelastine has been made using hepatocyte preparations from rat, dog, cynomolgus monkey, and man. metabolites and unchanged temelastine were separated by hplc and were compared with authentic standards by retention. the characteristic uv spectra of sk&f 93944 and its metabolites aided in the preliminary identification of metabolites in hepatocyte incubates, subsequently confirmed by liquid chromatography/mass spectrometry (lc/ms). the metabolic ... | 1990 | 1971564 |
| disposition in animals of a new anti-hiv agent: 2',3'-didehydro-3'-deoxythymidine. | the pharmacokinetics and cns penetration of the anti-human immunodeficiency virus agent 2',3'-didehydro-3'-deoxythymidine have been examined in cd-1 mice. the drug was rapidly cleared from plasma with a terminal half-life of 17 min after an iv bolus dose at 25 mg/kg. oral absorption of 2',3'-didehydro-3'-deoxythymidine was rapid and complete (98% bioavailable) with plasma levels approximately the same as those measured after iv administration. estimates of the total body clearance and apparent v ... | 1990 | 1971565 |
| effects of inhibition of norepinephrine synthesis on spontaneous and growth hormone-releasing hormone-induced gh secretion in cynomolgus macaques: evidence for increased hypothalamic somatostatin tone. | to define the role of noradrenergic regulation of growth hormone (gh) secretion in a primate species, spontaneous and gh-releasing hormone (ghrh) stimulated gh secretion was studied in 6 chronically catheterized adult male cynomolgus monkeys before and after inhibition of norepinephrine synthesis. blood samples were obtained at 15-min intervals during an 8-hour period to characterize the pattern of gh secretion, and the gh response to ghrh, 10 micrograms/kg i.v., was determined. these measuremen ... | 1990 | 1971714 |
| the organization of chemically-identified neural systems in monkey prefrontal cortex: afferent systems. | 1. immunohistochemical methods were used to identify dopaminergic, noradrenergic, cholinergic and serotonergic axons in cynomolgus monkey prefrontal cortex. 2. the densities of dopaminergic and noradrenergic systems varied in a similar fashion across prefrontal cortical regions, whereas the densities of cholinergic and serotonergic axons were regionally homogeneous. 3. in contrast, the laminar distributions of labeled axons were very different among these four systems. 4. the different patterns ... | 1990 | 1972800 |
| isolation and characterization of an ether glucuronide of zidovudine, a major metabolite in monkeys and humans. | a major metabolite of zidovudine (3'-azido-3'-deoxythymidine, azt), which previously had not been observed in a variety of experimental animals, was identified in samples of plasma and urine from cynomolgus monkeys and a patient treated with azt. the urinary recoveries of metabolite from the monkeys and the patient were, respectively, 1.5- and 6.9-fold higher than the recoveries of unchanged drug. the metabolite was purified in gram quantities from the urines of the monkeys and the patient and w ... | 1990 | 1974193 |
| pharmacokinetics of the anxiolytic beta-carboline derivative abecarnil in the mouse, rat, rabbit, dog, cynomolgus monkey and baboon. studies on species differences. | the pharmacokinetics of abecarnil (isopropyl 6-(benzyloxy)-4-(methoxymethyl)-9h-pyrido [3,4-b] indole-3-carboxylate, zk 112 119) were studied in the mouse, rat, rabbit, dog, cynomolgus monkey and baboon using 14c-labeled drug and hplc with fluorescence detection for measurement of unchanged drug. abecarnil was rapidly and completely absorbed after oral doses of 10 mg/kg. at higher doses, absorption was prolonged and incomplete in the cynomolgus monkey. the bioavailability of abecarnil was 20-30% ... | 1990 | 1974427 |
| cholinergic and noradrenergic nervous systems in the cynomolgus monkey cochlea. | the cholinergic and noradrenergic nervous systems in the cochleas of cynomolgus monkeys were examined by histochemical and immunohistochemical demonstration of acetylcholinesterase (ache) and tyrosine hydroxylase (th) and/or dopamine b-hydroxylase (dbh), respectively. ache activity was demonstrated in the efferent fibers making synaptic contact with the perikarya and the cell processes of type ii neurons. type ii neurons also demonstrated ache activity on the cell surface and their neurites, sug ... | 1990 | 1974732 |
| isolation and culture of hepatocytes from the cynomolgus monkey (macaca fascicularis). | isolation and culture techniques for hepatocytes from whole livers of the cynomolgus monkey, macaca fascicularis, are described. hepatocytes were isolated by two-step perfusion of livers, using collagenase with hyaluronidase; fructose and trypsin inhibitor were included to reduce cell loss. yields from a single liver average 4 x 10(9) cells with viabilities of 90.8 +/- 5.7%. cells, plated on collagen substrates, were assessed for changes in morphology and various marker enzyme activities over a ... | 1990 | 1975577 |
| interspecies comparison of the pharmacokinetics of aldose reductase inhibitors. | the pharmacokinetics of three aldose reductase inhibitors (aris) were evaluated in various species, including rat, dog, cynomolgus monkey, rhesus monkey, chimpanzee, and man. the three aris (al01567, al01576, and al01750) were administered intravenously as a single dose to all species except rat, which was dosed orally with al01750, and man, who was dosed orally with al01567 and al01576. plasma drug concentrations were measured by hplc or liquid scintillation spectrometry and various pharmacokin ... | 1990 | 1976064 |
| catecholaminergic innervation of the hippocampus in the cynomolgus monkey. | we studied the immunocytochemical distribution of catecholaminergic fibers in the hippocampal formation from two cynomolgus monkeys by using phenylethanolamine-n-methyltransferase, dopamine-beta-hydroxylase, and tyrosine-hydroxylase antibodies. there were no phenylethanolamine-n-methyltransferase immunoreactive fibers suggesting the lack of epinephrine containing fibers. in order to compare the distributions of tyrosine-hydroxylase and dopamine-beta-hydroxylase immunoreactive fibers, we counted ... | 1990 | 1976657 |
| preliminary report: protection of cynomolgus macaques against simian immunodeficiency virus by fixed infected-cell vaccine. | cynomolgus macaques were vaccinated with inactivated simian immunodeficiency virus-infected cells and 'quil-a' as adjuvant at 0, 4, 8, and 36 weeks or at 0, 4, 8, and 16 weeks. 2 weeks later these animals, together with a similar unvaccinated group, were challenged with 10 mid50 (50% monkey infectious doses) of a pool of sivmac251 previously titrated in vivo. virus was repeatedly isolated from unvaccinated animals on at least five separate occasions and proviral dna was detected in circulating l ... | 1990 | 1979369 |
| infection of cynomolgus monkeys with hiv-2 protects against pathogenic consequences of a subsequent simian immunodeficiency virus infection. | simian immunodeficiency virus (siv) infection in cynomolgus macaques leads to severe immunodeficiency with a fatal outcome. in contrast, hiv-2 infects these primates without apparently causing any immunological abnormalities. in this study three cynomolgus monkeys were experimentally infected with hiv-2 strain sbl-k135 and 168 days later challenged with 10-100 animal infectious doses of the closely related siv strain sm to study protective immunity. at the time of siv challenge the hiv-2-infecte ... | 1990 | 1979745 |
| multiple mrnas of monkey tyrosine hydroxylase. | the multiplicity of tyrosine hydroxylase (th) mrna was examined in two species of primate, macaca irus and macaca fuscata, one species of insectivore, sunkus murinus and one species of rodent, rat. to investigate the th multiplicity, total rnas from various species of animals were reverse transcribed and 5' portion of th cdnas were amplified by polymerase chain reaction. the resulted dna fragments were analyzed by agarose gel electrophoresis. two types of th mrna corresponding to type 1 and type ... | 1990 | 1980067 |
| argon laser irradiation of the otolithic organ. | an argon laser was used to irradiate the otolithic organs of guinea pigs and cynomolgus monkeys. after stapedectomy, the argon laser (1.5 w x 0.5 sec/shot) irradiated the utricle or saccule without touching the sensory organs. the stapes was replaced over the oval window after irradiation. the animals used for acute observation were killed immediately for morphologic studies; those used for long-term observation were kept alive for 2, 4, or 10 weeks. acute observation revealed that sensory and s ... | 1990 | 1980533 |
| quisqualate- and nmda-sensitive [3h]glutamate binding in primate brain. | excitatory amino acids (eaa) such as glutamate and aspartate are probably the neurotransmitters of a majority of mammalian neurons. only a few previous studies have been concerned with the distribution of the subtypes of eaa receptor binding in the primate brain. we examined nmda- and quisqualate-sensitive [3h]glutamate binding using quantitative autoradiography in monkey brain (macaca fascicularis). the two types of binding were differentially distributed. nmda-sensitive binding was most dense ... | 1990 | 1981916 |
| chronic intravenous toxicity of the new antibiotic cefpirome in monkeys. | chronic intravenous toxicity studies in monkeys were carried out with 3-[(2,3-cyclopenteno-1-pyridinium)-methyl]-7-[2-syn-methoximino - 2-(2-aminothiazol-4-yl)-acetamido]-ceph-3-em-4-carboxylate (cefpirome, hr 810; cas 84957-29-9) a new cephalosporin derivative. in a 90-day study in rhesus monkeys (4 males/4 females per group) dosages of 0, 50, 160 and 500 mg/kg/day were administered. in a 6-month study 5 groups of 6 male and 6 female cynomolgus monkeys received nacl-solution (0.9%), the vehicle ... | 1990 | 1982210 |
| the resection of orbicularis oculi muscle from the upper eyelid in experimental surgery on the monkey. | the purpose of this study was to determine the maximum amount of orbicularis oculi muscle that may safely be resected from the upper eyelid without causing functional abnormalities. measured amounts of that muscle were surgically excised from both upper eyelids in six cynomolgus monkeys. all the eyelids were photographed and videotaped at progressively increased intervals to permit the evaluation of wound healing, scarring, and function. our preliminary results revealed that the excision of pres ... | 1991 | 1984280 |
| early visual deprivation results in persistent strabismus and nystagmus in monkeys. | to understand to what extent visual-pattern deprivation during infancy results in strabismus and nystagmus, the authors examined the long-term consequences of this type of deprivation in monkeys during the first 50 days of life. three cynomolgus and three rhesus monkeys had the eyelids sutured closed within 24 hr of birth. at 25 days of age, the eyelids were opened, and the eyelids of the fellow eye were sutured closed for an additional 25 days (reverse-eyelid suture). when the eyelids were open ... | 1991 | 1987095 |
| morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. | nine eyes of five cynomolgus monkeys were perfused through the anterior chamber with cationized ferritin (cf) at normal and increased intraocular pressure. after perfusion with glutaraldehyde, the morphologic appearance of the endothelial lining of schlemm's canal (sc) and of the adjacent regions was analyzed using tangential and sagittal serial sections. the cf, which binds to negatively charged surfaces, was observed to be adherent to the free surfaces of trabecular cell membranes and to accum ... | 1991 | 1987099 |
| effect of systemic exposure to parathion on the dark adapted pupil dilation of cynomolgus monkeys. | the constriction of pupil dilation following dark adaptation was studied as a potentially useful biological monitor of systemic exposure to organophosphorus pesticides (ops). pupil dilation and blood cholinesterase levels were monitored in 4 cynomolgus monkeys following oral administration of 2.0 mg/kg parathion in corn oil. no consistent pattern of change in pupil/iris diameter ratios following exposure was found despite depressions in blood cholinesterase activities of 27-50% for red cells and ... | 1991 | 1987364 |
| analysis of cellular events within stable and rejecting allografts in cynomolgus monkeys. | | 1991 | 1990702 |
| biological control of primate macular pigment. biochemical and densitometric studies. | the amounts of zeaxanthin (z) and lutein (l), the carotenoids constituting the primate macular pigment, were measured in the central retinas of monkeys (saimiri sciureus and macaca fascicularis). two independent methods--reverse-phase high-performance liquid chromatography (hplc) and microdensitometry--were used for analysis of the same set of retinas. most of the measurements were made on retinas that had been fixed by glutaraldehyde-paraformaldehyde perfusion of the animal. control experiments ... | 1991 | 1993576 |
| distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys. | the spatial distribution of lutein (l) and zeaxanthin (z), the structural isomers composing the macular pigment, was studied in the retinas of macaque monkeys (macaca fascicularis) and squirrel monkeys (saimiri sciureus). spatial profiles of macular pigment optical density were obtained from retinal whole mounts. then concentric annuli were microdissected from the fovea and adjacent regions of the same retinas. each retinal segment was analyzed for carotenoids by high-performance liquid chromato ... | 1991 | 1993577 |
| regeneration through nerve allografts in the cynomolgus monkey (macaca fascicularis). | with the use of ulnar nerves of cynomolgus monkeys, the present study examined whether basal laminae of schwann cells can serve as conduits for regenerating axons in nerve allografts from non-human primates. a segment of ulnar nerve was transected distal to the elbow joint one week before grafting. in group a, a distal segment of the transected nerve was transplanted, after freezing and thawing, into the ulnar nerve of another monkey, at a level that corresponded to that from which the graft was ... | 1991 | 1993712 |
| effect of 21-aminosteroid u-74006f on lipid peroxidation in subarachnoid clot. | the present study was undertaken to investigate the effect of u-74006f on malondialdehyde (a by-product of lipid peroxidation) in subarachnoid clot. eighteen cynomolgus monkeys were divided into three groups of six each. there were two u-74006f-treated groups, receiving doses of 0.3 or 1.0 mg/kg, and a placebo-treated group. each monkey underwent baseline cerebral angiography followed by right-sided craniectomy and placement of subarachnoid clot around the middle cerebral artery (mca). treatment ... | 1991 | 1993911 |
| renin inhibitory peptides. incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys. | we previously reported that boc-pro-phe-n-mehis-leu psi [chohch2]-ile-amp (1) is a potent and specific inhibitor of human renin in vitro. it was shown to resist degradation by selected proteases and a rat liver homogenate. it was shown to inhibit plasma renin activity and to reduce blood pressure in renin-dependent-animal models both by the intravenous and by the oral routes using dilute citric acid as vehicle. in an effort to discover compounds with improved pharmacological efficacy, we set out ... | 1991 | 1995887 |
| resolution of the african hominoid trichotomy by use of a mitochondrial gene sequence. | mitochondrial dna sequences encoding the cytochrome oxidase subunit ii gene have been determined for five primate species, siamang (hylobates syndactylus), lowland gorilla (gorilla gorilla), pygmy chimpanzee (pan paniscus), crab-eating macaque (macaca fascicularis), and green monkey (cercopithecus aethiops), and compared with published sequences of other primate and nonprimate species. comparisons of cytochrome oxidase subunit ii gene sequences provide clear-cut evidence from the mitochondrial g ... | 1991 | 1996358 |
| gustatory neural coding in the monkey cortex: stimulus intensity. | 1. we analyzed the activity of single neurons in gustatory cortex of alert cynomolgus monkeys in response to a range of stimulus intensities. chemicals were deionized water, fruit juice, and several concentrations of the four prototypical taste stimuli: 10(-3)-1.0 m glucose, 10(-3)-1.0 m nacl, 10(-4)-3 x 10(-2) m hcl, and 10(-5)-3 x 10(-3) m quinine hcl. 2. taste-evoked responses could be recorded from a cortical gustatory area that measured 2.5 mm in its anteroposterior extent, 6.0 mm dorsovent ... | 1991 | 1999734 |
| the thyroid hormone analogue skf-94901 and iodothyronine binding sites in mammalian tissues: differences in cytoplasmic binding between liver and heart. | the thyroid hormone analogue, skf-94901 exhibits greater thyromimetic activity in the liver than in the heart. this difference in activity may reflect heterogeneity in the affinity of skf-94901 for different forms of the t3 receptor. a difference in extranuclear transport of the analogue could also account for the different response of these two tissues. to distinguish between these possibilities we have examined the binding of skf-94901 to membrane, cytosolic and nuclear preparations from liver ... | 1991 | 2000700 |
| testosterone regulates pro-opiomelanocortin gene expression in the primate brain. | endogenous opioid peptides such as beta-endorphin, derived from proopiomelanocortin (pomc), have been widely implicated as serving an important role in the neuroendocrine regulation of the primate reproductive axis. in both human and nonhuman primates, pomc neurons are thought to mediate, at least in part, the negative feedback action of sex steroids on gnrh. sex steroids, such as testosterone, are thought to inhibit gnrh secretion by enhancing the inhibitory activity of beta-endorphin; however, ... | 1991 | 2004607 |
| inhibition of peripheral aromatization in the male cynomolgus monkey by a novel nonsteroidal aromatase inhibitor (r 76713). | r 76713 (6-[(4-chlorophenyl)(1-h-1,2,4-trizol-1-yl)methyl]1-h benzotriazole) is a highly potent and selective inhibitor of the aromatase enzyme both in vitro and in vivo. the ability of r 76713 to inhibit peripheral aromatization of androstenedione (a) to estrone (e1) in vivo was studied in male cynomolgus monkeys (macaca fascicularis). peripheral aromatization was measured using a primed constant infusion of [3h] a and [14c]e1 for 3.5 h. blood samples, collected during the final hour of infusio ... | 1991 | 2005200 |
| transplantation of vascularized composite mandibular allografts in young cynomolgus monkeys. | in the search for donor tissue for massive craniofacial defects, the transplantation of somatic tissue allografts was explored. four young, out-bred cynomolgus monkeys were the recipients of orthotopic hemimandibular allotransplants from nonrelated cynomolgus monkeys. the transplant consisted of one-half of the mandible with attached muscle, skin, and mucosa. cyclosporine 15 mg/kg/day was given subcutaneously each day. the 4 monkeys were observed for 13, 27, 63, and 65 days, respectively. all tr ... | 1991 | 2006838 |
| [the effect of a high-intensity radiation exposure on the brain function of monkeys. the postradiation changes in brain bioelectrical activity]. | in experiments with macaca fascicularis it has been found that changes in the total bioelectric activity of the brain within the eeg range that occur during the first 60 min following whole-body irradiation with a dose of 45 gy (6.5 gy/s) are interrelated with the dynamics of nervous and psychic activity of the exposed animals, exhibit a definite stereotype of their development (disorganization of rhythms: generalized synchronization of biopotentials; and development of synchronous processes), a ... | 1991 | 2008531 |
| biotransformation of scoparone used to monitor changes in cytochrome p450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeys. | the coumarin derivative scoparone is regioselectively demethylated yielding isoscopoletin and scopoletin. the ratio of the formation rates of these two metabolites (isoscopoletin/scopoletin; i/s ratio) is reported to mirror the contribution of several cytochrome p450 (p450) isoenzymes to the biotransformation of scoparine. the metabolism of scoparine has been studied in primary liver cell cultures of rats, hamsters, cynomolgus monkeys and in human liver cells. rat hepatocytes appeared to metabol ... | 1991 | 2009095 |
| periodontium response to a root canal condensing device (endotec). | two macaca (fascicularis) monkeys were used to study the effect of two warm endodontic condensation techniques (endotec and vertical condensation method) on periodontal tissues. the specimens were histologically evaluated at 3 and 32 days after the endodontic treatments were completed. in this study the periodontium was divided into coronal, middle, and apical thirds. results indicated that there was no heat-related damage to periodontal tissues from either of the two methods employed. however, ... | 1991 | 2011357 |
| immediate and delayed direct pulp capping with the use of a new visible light-cured calcium hydroxide preparation. | the pulpal response to mechanical exposure and capping either immediately or after 24 hours was investigated in 64 teeth of four cynomolgus monkeys with the use of dycal, vlc dycal, or prisma-bond. all overlying amalgam restorations were surface-sealed with zinc oxide-eugenol cement. after 2 months the teeth were removed and prepared for histologic examination; dentine bridges were present in almost all teeth filled with dycal or vlc dycal, and pulpal inflammation was observed in only one tooth ... | 1991 | 2011358 |
| anti-tac-h, a humanized antibody to the interleukin 2 receptor, prolongs primate cardiac allograft survival. | high-affinity interleukin 2 receptors (il-2rs) are expressed by t cells activated in response to foreign histocompatibility antigens but not by normal resting t cells. to exploit this difference in il-2r expression, anti-tac-m, a murine monoclonal antibody specific for the il-2r alpha chain, was used to inhibit organ allograft rejection. however, the use of murine anti-tac as an immunosuppressive agent was limited by neutralization by human anti-murine antibodies and by weak recruitment of effec ... | 1991 | 2011577 |
| synthesis of il-1 alpha and il-1 beta by arterial cells in atherosclerosis. | interleukin-1 (il-1) has been implicated as a regulatory protein in the development and clinical sequelae of atherosclerosis. to determine which cells in the atherosclerotic plaque synthesize il-1 in situ, the authors evaluated histologic sections of iliac arteries from cynomolgus monkeys using probes for il-1 alpha and beta. a polyclonal antibody to il-1 alpha and beta was used to determine if proteins were concomitantly produced. the predominant cells expressing il-1 alpha and beta mrna were f ... | 1991 | 2012178 |
| effects of atherosclerosis and regression on vascular responses to products of activated platelets in primates. | we aggregated human platelets in vitro and examined vascular responses to injection of the supernatant in atherosclerotic primates. platelets were washed, suspended, and aggregated with thrombin. thrombin was then inactivated with d-phe-pro-argch2cl, and the suspension was centrifuged. the supernatant was injected intra-arterially into the perfused hindlimb within 30 s after aggregation of platelets. we studied normal cynomolgus monkeys, atherosclerotic monkeys that were fed atherogenic diet for ... | 1991 | 2012210 |
| half-life, hemodynamic, renal, and hormonal effects of prorenin in cynomolgus monkeys. | prorenin is found in human plasma, kidneys, and reproductive organs. we investigated the physiological and pharmacokinetic properties of plasma prorenin, and its plasma conversion to active renin, by bolus infusions of human recombinant prorenin (0.5, 2, 20 micrograms; n = 4/dose) into anesthetized male cynomolgus monkeys. the infused prorenin had 3% intrinsic renin activity. plasma prorenin rose from 61 +/- 6 to 101 +/- 11, 570 +/- 46, and 7,700 +/- 390 ng.ml-1.h-1, respectively, after 5 min. p ... | 1991 | 2012251 |
| effects of single and multiple inhalations of antigen on airway responsiveness in monkeys. | airway hyperresponsiveness is an important and characteristic feature of asthma. in monkeys, we have reported that antigen (ag) inhalation induces a prolonged airway eosinophilia, that chronic airway eosinophilia is associated with marked airway hyperresponsiveness, and that chronic ag inhalations induce airway eosinophilia and hyperresponsiveness. in this study we have determined the effects of acute ag inhalation(s) on airway responsiveness to obtain a protocol for the study of the mechanisms ... | 1991 | 2013678 |
| precipitation of the renin inhibitor ditekiren upon i.v. infusion; in vitro studies and their relationship to in vivo precipitation in the cynomolgus monkey. | ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. preclinical drug safety studies with this drug involved continuous i.v. infusions through indwelling catheters in the right internal jugular vein of the cynomolgus monkey for up to 30 days. the following physiocochemical properties of ditekiren make it susceptible to intravascular precipitation immediately following iv infusion: (1) the water solubility of ditekiren is high at acidic ph where the drug is formulated ... | 1991 | 2014212 |
| localization of androgen receptor in the follicle and corpus luteum of the primate ovary during the menstrual cycle. | ovarian androgens may act locally to modulate follicular and luteal function in various species. this study examined the distribution of androgen receptors within the primate ovary throughout the menstrual cycle. ovaries were collected from rhesus and cynomolgus monkeys during the early, mid-, and late (n = 3-5 per stage) follicular and luteal phases of the cycle. the tissues were processed for indirect immunocytochemical localization of androgen receptors with a specific monoclonal antibody aga ... | 1991 | 2015374 |
| pericyte changes in branch retinal vein occlusion. | the model of experimental branch vein occlusion (bvo) in the monkey offers the opportunity to examine retinal capillaries under stress. electron microscopic morphometry was done on 812 capillaries of 13 eyes of cynomolgus monkeys, comparing 579 capillary collaterals of 9 bvo eyes with 233 normal capillaries of 4 control eyes. the tissue underwent the myosin subfragment-1 technique to decorate and quantify bundles of actin filaments in capillary pericytes. the duration of bvo was 2-48 months. cap ... | 1991 | 2016128 |
| experimental ocular onchocerciasis in cynomolgus monkeys. iv. chorioretinitis elicited by onchocerca volvulus microfilariae. | onchocerciasis is a major cause of blindness worldwide, and much of the blindness is caused by onchocercal chorioretinitis. in an experimental animal model for ocular onchocerciasis, intravitreal injections of 10,000 live onchocerca volvulus microfilariae isolated from infected humans into the eyes of cynomolgus monkeys (macaca fascicularis) resulted in patchy, progressive loss of retinal pigment with pigment clumping. areas of pigment loss were less extensive in animals that had been sensitized ... | 1991 | 2016131 |
| cytochalasin b potentiates epinephrine's outflow facility-increasing effect. | total outflow facility was determined in both eyes of cynomolgus monkeys by two-level constant pressure perfusion. after a baseline measurement, one eye of the experimental animal received intracameral cytochalasin b (cb); the other eye received vehicle without cb. twenty minutes later both eyes received intracameral epinephrine (epi), and 30 min later the outflow facility was again determined. doses of cb and epi which were subthreshold when given singly produced significant facility increases ... | 1991 | 2016142 |
| antiviral effects of 3'-fluorothymidine and 3'-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus. | an acute infection with simian immunodeficiency virus (sivsm) in cynomolgus monkeys was used to evaluate the antiviral effects of 3'-fluorothymidine (flt) and 3'-azidothymidine [zidovudine (zdv)]. neither compound prevented the infection despite dosing prior to virus inoculation. flt was about ten times more potent than zdv in delaying the appearance of sivsm antigen in the monkeys. the serum half-life of flt was longer than that of zdv and zdv was bound to plasma proteins to about 60% while flt ... | 1991 | 2016686 |
| endothelial dysfunction in response to psychosocial stress in monkeys. | the current study was designed to evaluate the effects of a disrupted social environment on the endothelial integrity of various vascular segments in male cynomolgus monkeys (macaca fascicularis). each of 20 single-caged adult monkeys was fed a diet comparable to a person's ingestion of 240 mg cholesterol/day for a 10-week baseline period and then was introduced as a stranger into a four-member social group for 3 days. half of the monkeys received a beta-adrenergic blocking agent (metoprolol) vi ... | 1991 | 2018991 |
| anatomic correlates of aortic pulse wave velocity and carotid artery elasticity during atherosclerosis progression and regression in monkeys. | we noninvasively measured changes in average aortic stiffness in 79 cynomolgus monkeys being fed cholesterol progression, regression, and control diets by measuring pulse wave velocity (pwv) in 260 experiments during a 30-month period. every 6 months, a group of monkeys was studied with invasive aortic pwv techniques and with ultrasonically determined pressure-strain elastic modulus (ep) of the carotid artery, and then the group was killed so that morphometric evaluation of atherosclerosis sever ... | 1991 | 2022028 |
| plasma lipid transfer protein as a determinant of the atherogenicity of monkey plasma lipoproteins. | this study was undertaken to determine potential tissue sources of plasma cholesteryl ester transfer protein (cetp), and to assess the influence of cetp on lipoprotein concentrations and atherosclerosis. in a group of 28 cynomolgus monkeys fed high fat, high cholesterol diets, plasma cetp concentration was strongly correlated with the abundance of cetp mrna in liver and in adipose tissue, and with the output of cetp in liver perfusates. plasma cetp concentration showed a strong inverse correlati ... | 1991 | 2022728 |
| evaluation of the onset and duration of response to cold air inhalation challenge in cynomolgus monkeys (macaca fascicularis). | cold air inhalation challenge (caic) for the evaluation of bronchial reactivity has been proposed as a physical agent alternative to chemical agent challenges (methacholine or histamine), especially suitable for the occupational environment. the present investigation describes and evaluates a method for performing cold air inhalation challenge in cynomolgus monkeys (macaca fascicularis), a species shown to be useful in animal modeling studies of occupational asthma. six adult male anesthetized m ... | 1991 | 2022812 |
| displacement of the optic nerve head by acute changes in intraocular pressure in monkey eyes. | the authors used the humphrey retinal analyzer to study the effect of acute changes in intraocular pressure (iop) on the topography of the optic nerve head in normotensive and hypertensive eyes of cynomolgus monkeys. chronically elevated iop was produced monocularly in monkeys by argon laser angle treatment. in 8 hypertensive eyes, the mean iop of 51 mmhg was lowered acutely to 15 mmhg with a needle placed in the anterior chamber. in 12 normotensive eyes, the mean iop of 16 mmhg was similarly in ... | 1991 | 2023730 |
| clinicopathologic correlation of diode laser burns in monkeys. | one hundred twenty-five retinochoroidal photocoagulation burns, produced by a transpupillary diode laser (810 nm) in six eyes of three cynomolgus monkeys, were evaluated by clinicopathologic correlation for up to 9 weeks after laser treatment. diode burns of clinical grade 2 strength were comparable to those described for argon laser. however, diode burns of clinical grade 3 strength produced choroidal changes more intense than those described for argon laser. where present underneath photocoagu ... | 1991 | 2025166 |
| distribution of choline acetyltransferase-immunoreactive axons in monkey frontal cortex. | cholinergic neurons of the nucleus basalis of meynert project to numerous regions of the cerebral cortex. however, little is known about the regional and laminar distributions of cholinergic axons in monkey frontal cortex. in this study, immunohistochemical techniques were used to identify axons that were immunoreactive for choline acetyltransferase, the enzyme that catalyses the synthesis of acetylcholine, in the frontal cortex of cynomolgus monkeys. motor cortex contained the greatest density ... | 1991 | 2027466 |
| long-term cholesterol feeding alters the reactivity of primate coronary microvessels to platelet products. | hypercholesterolemia impairs endothelium-dependent relaxations to several platelet-derived substances in large vessels. the effect of hypercholesterolemia on the response of coronary microvessels to platelet products and thrombin is less well defined. three groups of cynomolgus monkeys were studied: normal (n = 6), short-term hypercholesterolemic (8-11 weeks, n = 5), and long-term hypercholesterolemic (18-80 months, n = 6). responses of coronary microvessels, 100-200 microns in diameter, to thro ... | 1991 | 2029502 |
| similar patterns of dna adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the fischer 344 rat, cdf1 mouse, cynomolgus monkey and salmonella typhimurium. | 2-amino-3-methylimidazo [4,5-f]quinoline (iq) is a known liver carcinogen in the fischer 344 rat, the cdf1 mouse and in the cynomolgus monkey. using 32p-postlabeling assays, we compared iq-dna adduct formation in the liver of iq-treated fischer 344 rats, cdf1 mice and cynomolgus monkeys with that in salmonella typhimurium (strain ta98) incubated with iq (in the presence of a liver s9 activating system) or n-hydroxy-iq. up to five adducts could be detected, the pattern of which was identical in a ... | 1991 | 2029759 |
| pharmacokinetic and pharmacodynamic analysis of a human immunoglobulin m monoclonal antibody in neonatal macaca fascicularis. | we have developed a human mab that opsonizes group b streptococci, the major cause of gram-positive bacterial sepsis in newborns. it is an igm class human mab that possess unique protective activity against experimental infections caused by the predominant group b capsule serotypes iii and i. preliminary preclinical studies with the igm human mab were designed to provide initial information useful for predicting its safety and pharmacokinetic properties. two neonatal macaca fascicularis monkeys ... | 1991 | 2034481 |
| [effect of a high-intensity radiation exposure on brain function in monkeys. postradiation changes in central coordination of brain bioelectrical processes]. | in experiments with macaca fascicularis exposed to high-energy electrons (45 gy, 6.5 gy/s) revealed were early changes in the coherent spectrum of eeg semihemispheric leads. these changes were displayed by the increased interrelation between slow-wave fluctuations and decreased coherence within the mid- and high-frequency eeg-rhythms band. the relationship was noted between the changes observed and the clinical symptoms features of early radiation response as well as the dynamics of the cns func ... | 1991 | 2034804 |
| beta-hydroxybutyrate: a urinary marker of imipenem induced nephrotoxicity in the cynomolgus monkey detected by high field 1h nmr spectroscopy. | the use of 1h nmr as a complement to conventional clinical chemistry and histopathology resulted in the detection of hitherto unsuspected changes in urine composition as a result of imipenem induced nephrotoxicity. large quantities of beta-hydroxybutyrate, as well as other ketone bodies were detected, indicating a disruption of energy metabolism. beta-hydroxybutyrate may provide a useful non-invasive marker for imipenem toxicity. | 1991 | 2039554 |
| effect of methylmercury on acetylcholinesterase and serum cholinesterase activity in monkeys, macaca fascicularis. | | 1991 | 2039873 |
| unit activity in the hippocampus and the parahippocampal temporobasal association cortex related to memory and complex behaviour in the awake monkey. | monkeys (macaca fascicularis) were trained on a delayed match-to-sample (dms) task using delays of upto 20 s. unit activity was recorded from the hippocampus and the temporo-basal association cortex in the lateral parahippocampal region (partly corresponding to tf and th) during the dms task, as well as during a visual object discrimination task and some behavioural situations involving the experimenter. units were encountered that gave visual responses which were sometimes context-dependent. ch ... | 1991 | 2039943 |
| antide-induced suppression of pituitary gonadotropin and ovarian steroid secretion in cynomolgus monkeys: premature luteolysis and prolonged inhibition of folliculogenesis following single treatment. | administration of high-dose antide to ovariectomized monkeys results in rapid, prolonged, and reversible inhibition of gonadotropin secretion. the present study examined whether similar long-term control would be manifested in the menstrual cycle of intact primates. antide administration at a dose of either 3.0 or 18.0 mg/kg induced rapid suppression of bioassayable lh concentrations, precipitating a concurrent fall in serum progesterone concentrations from 7.9 +/- 3.6 and 5.8 +/- 1.0 ng/ml (mea ... | 1991 | 2043741 |
| primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor. | 1. octimibate is a potent inhibitor of human platelet aggregation, and appears to act (at least in part) through the prostacyclin receptor, as described in the preceding paper. here, the vascular effects, both in vitro and in vivo, of octimibate have been compared to those of the stable prostacyclin (pgi2) mimetic, iloprost. since octimibate shows extensive species variation and is potent at inhibiting platelet aggregation in primates, all of the experiments reported here have been carried out w ... | 1991 | 2043927 |
| magnetic resonance imaging of experimental allergic encephalomyelitis in primates. | the potential use of quantitative mri to characterize early, as well as late, immune-mediated lesions of multiple sclerosis (ms) has been investigated. experimental allergic encephalomyelitis (eae) was induced in 4 male macaca fascicularis monkeys, and the development of the disease followed using quantitative mri at 0.15 tesla. serial scans were recorded daily, beginning at day 9 after inoculation. lesions were detected before the onset of clinical signs, due to an elevation in the spin-lattice ... | 1991 | 2043942 |
| [morphometrical study of physical growth of laboratory-bred cynomolgus monkeys aged from zero to 9 years]. | the relative growth was examined in laboratory-bred cynomolgus monkeys (macaca fascicularis) aged from zero to 9 years. the principal component analysis and multivariate allometry were applied to the biometrical data. as the result of the principal component analysis, the cumulative contribution ratio of the 1 st (pc 1) and 2 nd (pc 2) principal components accounted for 99.0 percent. according to the eigen vector values of each morphological site (14 sites), pc 1 was acceptable not only as a siz ... | 1991 | 2044668 |
| assessment of abdominal fat deposition in female cynomolgus monkeys. | computed tomography (ct) was used to assess abdominal fat distribution in adult, female cynomolgus macaques (macaca fascicularis). the technique used was similar to that applied in human beings and allowed intra-abdominal, subcutaneous and total abdominal fat to be quantitated in 1 cm thick sections. correlations between single scans and the average of scans at several levels ranged from r = 0.96 to r = 1.00, indicating that a single scan is representative of abdominal fat distribution. signific ... | 1991 | 2045214 |
| combined effects of granulocyte-macrophage colony stimulating factor with erythropoietin in subhuman primates. | recently, we showed in a cynomolgus monkey model that the combination of interleukin-3 (il-3) and granulocyte-macrophage colony stimulating factors (gm-csf) demonstrates synergistic effects, if administered sequentially. not only were progenitor cells of the myelocytic lineage stimulated cooperatively, but platelet release was also observed. these effects could not be found using these factors alone. in this study, gm-csf was administered with erythropoietin (epo) in a sequential manner. this tr ... | 1991 | 2048558 |
| stimulatory effect of romurtide on hematopoiesis in monkeys. | repeated subcutaneous injections of romurtide (n2-[(n-acetylmuramoyl)-l-alanyl-d-isoglutaminyl]-n6-stearoyl-l-lysine, mdp-lys(l18), muroctasin; cas 78113-36-7), a synthetic muramyl dipeptide derivative, increased significantly the number of peripheral neutrophils and monocytes in a dose-dependent fashion in healthy cynomolgus monkeys (macaca fascicularis). the number of platelets was also increased significantly in monkeys with repeated dosing of romurtide. after single dosing of romurtide (1 mg ... | 1991 | 2049113 |
| contrasting properties of monkey somatosensory and motor cortex neurons activated during the control of force in precision grip. | 1. single cell activity was investigated in the precentral motor (mi) and postcentral somatosensory (si) cortex of the monkey to compare the neuronal activity related to the control of isometric force in the precision grip and to assess the participation of si in motor control. 2. three monkeys (macaca fascicularis) were trained in a visual step-tracking paradigm to generate and precisely maintain force on a transducer held between thumb and index finger. great care was taken to have the monkeys ... | 1991 | 2051196 |
| effect of a modified rectus tuck on anterior segment circulation in monkeys. | removal of a rectus muscle results in permanent interruption of blood flow in the corresponding anterior ciliary artery, predisposing to anterior segment ischemia (asi). a subhuman primate model of asi was developed in order to study a novel muscle tuck procedure designed to preserve anterior ciliary artery circulation. fluorescein angiograms were obtained before and after surgery to determine the effect of the muscle surgery on iris circulation. a total of 12 eyes from 12 cynomolgus monkeys und ... | 1991 | 2051293 |
| a primate model of macular cyst. | perfluoropropane (c3f8) was injected into nine eyes of six cynomolgus monkeys. in all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. on fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts. histopathologic evaluation of six eyes demonstrated microcystic changes throughout the perifoveal inner nuclear layer. these coalesced into larger cystic spaces in the outer plexif ... | 1991 | 2052310 |
| [histopathological study on the monkey retina and choroid by diode laser endophotocoagulation]. | the fundi of three cynomolgus monkeys were coagulated using a diode laser endophotocoagulator. the histopathological changes of the retina and the choroid were investigated periodically up to 3 months. the damage of the retina extended into the outer plexiform layer following mild burn, into the inner nuclear layer with moderate burn and into the nerve fiber layer on severe burn. the pigment epithelium proliferated with multiple layer cells 1-3 months after the irradiation. the choriocapillaries ... | 1991 | 2053522 |
| [experimental retinal branch vein occlusion]. | experimental retinal branch vein occlusion in monkeys (macaca irus) were produced by yellow wavelength (577nm) dye laser photocoagulation. the clinical sequence was observed in terms of the structural and ultrastructural findings occurring during the natural history of experimental branch vein occlusion, particularly in the early stage. immediately after the occlusion, venous dilatation and retinal edema and hemorrhage appeared. extravascular leakage of dye in fluorescein angiography and hemorrh ... | 1991 | 2053523 |
| effects of chronic caffeine consumption in pregnant monkeys (macaca fascicularis) on blood and urine clinical chemistry parameters. | pregnancy requires a variety of physiological adaptations to create an environment for the optimal development of the fetus. the widespread consumption of the methylxanthines especially caffeine and to a lesser extent theophylline by pregnant women suggests that it is important to determine whether these methylxanthines may influence maternal physiology during pregnancy. forty female monkeys (macaca fascicularis), randomly divided into three groups, were exposed to caffeine in their drinking wat ... | 1991 | 2055360 |
| cytotoxic t-cell response to simian immunodeficiency virus by cynomolgus macaque monkeys immunized with recombinant vaccinia virus. | simian immunodeficiency virus (siv) gag-specific major histocompatibility complex (mhc)-restricted cytotoxic t-lymphocyte (ctl) activity was elicited in four out of six cynomolgus macaques after two immunizations with siv gag recombinant vaccinia virus (rvv). no activity could be seen in three out of three non-immunized control animals. low levels of anti-gag antibody were also seen in the same four responding animals. virus-specific, mhc-restricted ctl are thought to give some protection and to ... | 1991 | 2059372 |
| simian immunodeficiency virus (sivsm) isolation from blood and brain of experimentally infected macaques. | the possibility of using simian immunodeficiency virus (siv)-infected macaques to study pathogenic events linked to hiv infection of the brain prompted us to investigate some of the virological features in siv-infected macaques. nine cynomolgus macaques were inoculated with sivsm and killed at different times. we successfully isolated virus from the blood of all the animals and from the brains of eight. these results point to the early and regular spread of this lentivirus to the brain. neutrali ... | 1991 | 2059387 |
| determinants controlling iatrogenic external root resorption and repair during and after palatal expansion. | the mechanisms controlling iatrogenic external root resorption (err) and repair were studied on 8 macaca fascicularis monkeys. the animals were divided into short-term and long-term groups, and were treated with jackscrew, magnetic and sham palatal expansion appliances. scanning electron microscopy morphometric analysis found major evidence of err in the tooth-borne jackscrew appliance, in the long-term group, in the maxillary premolars, on the buccal and furcation root surfaces, on the mesiobuc ... | 1991 | 2064069 |
| function of the supraorbital region of primates. | the purpose of this study was to test the hypothesis that the functional significance of well-developed brow-ridges in primates is to counter powerful masticatory forces during chewing and biting. this was done by measuring and analysing patterns of in vivo bone strain recorded from rosette strain gauges bonded to the supraorbital region of macaca fascicularis (the crab-eating or long-tailed monkey) and papio anubis (the olive baboon) during mastication and incision. it was found that the suprao ... | 1991 | 2064549 |
| vaccine protection against hiv-2 infection in cynomolgus monkeys. | the aim of this study was to determine if protection against an infectious human immunodeficiency virus type 2 (hiv-2) challenge could be obtained in cynomolgus macaques by active immunization using whole killed virus vaccine. four monkeys were immunized with killed hiv-2sbl-6669, two of them with five intramuscular (im) injections of viral preparation containing 100 or 300 micrograms protein emulsified in incomplete freund's adjuvant (ifa) and the two remaining received four im injections of 25 ... | 1991 | 2064826 |
| studies on the effect of dietary fish oil on the physical and chemical properties of low density lipoproteins in cynomolgus monkeys. | to determine the effect of isocaloric substitution of dietary fish oil for lard on the physical and chemical properties of plasma low density lipoproteins (ldl), ten adult male cynomolgus monkeys were fed diets containing 11% (by weight) fish oil or lard in a crossover study consisting of two 15-week periods with a 6-week washout period in between. the atherogenic diets contained 40% of calories as fat with 0.26 mg cholesterol/kcal. periodic measurements of plasma lipids were made throughout the ... | 1991 | 2066665 |
| a simple technique for collecting blood of testicular origin: application to in vivo studies on testicular steroidogenesis in rats and macaca fascicularis. | a technique for rapidly collecting blood of testicular origin is described, one which can provide sufficient plasma amounts to investigate some steps of testicular steroid biogenesis in vivo in 2 species. in adult male rats, testosterone (t), androstenedione (4a) and 5-androstenediol (5ad) were determined in pampiniform plexus testicular venous blood (pptv) and peripheral (pv) blood samples before and 2 h after human chorionic gonadotropin (hcg). pptv concentration of 5ad was 0.83 +/- 0.1 ng/ml ... | 1991 | 2069857 |
| autogenous auricular cartilage graft for temporomandibular joint repair. a comparison of technique with and without temporary silastic implantation. | four macaca fascicularis monkeys underwent bilateral temporomandibular joint surgery including disc removal, condyle recontouring and disc replacement using autogenous auricular cartilage grafts. one side was treated with the cartilage graft alone while the other side was treated with a cartilage graft combined with a temporarily implanted 0.02 inch dacron-reinforced silastic sheet. the silastic sheeting was removed at twelve weeks after the initial surgery. the monkeys were sacrificed at fourte ... | 1991 | 2071692 |
| a collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. | when a peripheral nerve is severed and left untreated, the most likely result is the formation of an endbulb neuroma; this tangled mass of disorganized nerve fibers blocks functional recovery following nerve injury. although there are several different approaches for promoting nerve repair, which have been greatly refined over recent years, the clinical results of peripheral nerve repair remain very disappointing. in this paper we compare the results of a collagen nerve guide conduit to the more ... | 1991 | 2071700 |
| cationization of immunoglobulin g results in enhanced organ uptake of the protein after intravenous administration in rats and primate. | cationization of proteins in general enhances the cellular uptake of these macromolecules, and cationized antibodies are known to retain antigen binding properties. therefore, cationized antibodies may be therapeutic and allow for "intracellular immunization." the present studies test the hypothesis that the tissue uptake of cationized immunoglobulin g (igg) after intravenous administration may be greatly increased relative to the uptake of native proteins. the pharmacokinetics of cationized imm ... | 1991 | 2072295 |
| multiple alpha-globin genes in crab-eating macaques (macaca fascicularis). | alpha-globin genes in crab-eating macaques were found to be triplicated at high frequencies according to restriction-enzyme comparisons. the frequencies of triplicated alpha-globin genes in macaques originally from malaysia and indonesia were 0.432 and 0.275, respectively, while no triplication was found in individuals from either the philippines or northern and central thailand. quadruplicated alpha-globin genes were also observed, at frequencies of 0.045 (malaysia), 0.075 (indonesia), and 0.02 ... | 1991 | 2072861 |
| blood-ocular barrier permeability in experimental myopia. | vitreous fluorophotometry (vfp) was performed for myopic eyes induced by unilateral eyelid suturing of six young cynomolgus monkeys in order to study the permeability of the blood-ocular barrier. the eyelid fusion was temporarily cut and opened at about five-month intervals, and the dioptric power and axial length of test and control eyes were measured. vfp was carried out before and after intravenous injections of fluorescein-na. the inward permeability of the blood-retinal barrier (p(in)) was ... | 1990 | 2081837 |
| [electron microscopy and immunohistochemical studies of the intraocular pressure lowering effect of prostaglandin f2 alpha]. | topically applied prostaglandin f2 alpha (pgf2 alpha) has been shown to lower intraocular pressure in cynomolgus monkeys. in this study the morphological changes following topical treatment of seven cynomolgus monkeys with 4 micrograms pgf2 alpha isopropylester for 5-8 days were investigated and compared with the eyes of five normal animals. quantitative light microscopical, ultrastructural and immunhistochemical methods were used. no cellular signs of inflammation were seen in any of the eyes. ... | 1990 | 2086407 |
| fields of origin and pathways of the interhemispheric commissures in the temporal lobe of macaques. | the interhemispheric connections of the cortical areas of the temporal lobe and some neighboring regions were investigated in monkeys (macaca mulatta and macaca fascicularis) by anterograde autoradiographic tracing, following injection of radioactively labeled amino acids. the results revealed that the interhemispheric projections of the temporal lobe course through three interhemispheric commissures on their way to the opposite hemisphere. the anterior commissure receives fibers from virtually ... | 1990 | 2086614 |
| the site of reattachment of the extraocular muscle following hang-back recession. | the use of "hang-back" suspensions has been shown to be an effective means of weakening rectus muscles. the exact position where the muscle reattaches to the globe has, however, been questioned. we performed eight large hang-back recessions on the rectus muscles of cynomolgus monkeys. eight weeks postoperatively the attachment sites were determined by reexploration. six of the recessions were within 0.5 mm of the intended site. the muscles were found an average of 0.4 mm anterior to the intended ... | 1990 | 2086743 |
| localization and responses of neurones in the parieto-insular vestibular cortex of awake monkeys (macaca fascicularis). | 1. in four java monkeys (macaca fascicularis) 152 vestibular neurones were recorded in the parietal cortex located in the upper bank of the lateral sulcus near the posterior end of the insula. we called this region parieto-insular vestibular cortex (pivc). pivc extends about 6-8 mm in the anterior-posterior direction from the posterior part of the insula into the retroinsular region (stereotaxic co-ordinates: anterior 4-12 mm, lateral 16-19 mm and vertical 3-6 mm). 2. about two-thirds of the neu ... | 1990 | 2086773 |
| vestibular neurones in the parieto-insular cortex of monkeys (macaca fascicularis): visual and neck receptor responses. | 1. one hundred and fifty-two vestibularly activated neurones were recorded in the parieto-insular vestibular cortex (pivc) of four awake java monkeys (macaca fascicularis): sixty-two were tested systematically with visual stimulation and seventy-nine were tested with various somatosensory stimuli. with very few exceptions all vestibular neurones tested responded to visual and somatosensory stimulation, therefore being classified as polymodal vestibular units. 2. a most effective stimulus for all ... | 1990 | 2086774 |
| effects of sensitization to dinitrochlorobenzene (dncb) on clinical pathology parameters and mitogen-mediated blastogenesis in cynomolgus monkeys (macaca fascicularis). | immunotoxicologic testing of drug candidates and environmental contaminants is of growing importance. cutaneous delayed type hypersensitivity (dth) is a convenient way of testing immune function in vivo. however, dth testing must not interfere with interpretation of other relevant parameters. we have evaluated the effects of sensitization and challenge with dinitrochlorobenzene (dncb) on clinical parameters routinely evaluated in toxicity testing and on lectin-mediated blastogenesis. female cyno ... | 1990 | 2093224 |
| parasympathetic denervation of the ciliary muscle following retinal photocoagulation. | cynomolgus monkeys underwent unilateral prp with xenon arc or argon or krypton laser light, employing burn intensity, size, spacing, and topography analogous to standard clinical (eg, diabetic retinopathy study) treatment. shortly thereafter, accommodative responsiveness to topical eserine and electrical stimulation of the ewn was diminished, accommodative responsiveness to systemic pilocarpine was enhanced, and the number of muscarinic receptors in the ciliary muscle was reduced in the prp-trea ... | 1990 | 2095033 |
| pneumotaxic mechanisms in the non-human primate: effect of the n-methyl-d-aspartate (nmda) antagonist ketamine. | we tested the possible involvement of n-methyl-d-aspartate (nmda) receptors in the central inspiratory-termination mechanism in non-human primates. inspiratory bursts were recorded from the phrenic nerve in macaca fascicularis monkeys paralyzed and ventilated by means of a servoventilator driven by the inspiratory discharge of the phrenic nerve. the central inspiratory termination mechanism was tested by withholding lung inflation. this transiently suppressed the vagal feedback from the lungs wh ... | 1990 | 2097589 |