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[pyrimidine metabolism in schistosoma japonicum]. 19836678666
[preliminary study on the in vitro cultivation of lung-phase schistosomula of schistosoma japonicum]. 19836678667
characterization of monoclonal antibodies against schistosoma mansoni.monoclonal antibodies directed against schistosoma mansoni antigens were produced by the in vitro fusion of b lymphocytes, obtained from mice infected with s. mansoni, and sp2/0 myeloma cells. antibody reactivity was assessed by elisa binding, utilizing 4 m kcl extracts of cercariae and adult worms, soluble egg antigen (sea), and purified antigenic preparations, and by indirect immunofluorescence using living schistosomula. the monoclonal antibodies recognized a wide spectrum of antigenic determ ...19836681690
eosinophil chemotactic factor in schistosome eggs: a comparative study of eosinophil chemotactic factors in the eggs of schistosoma japonicum and s. mansoni in vitro.significant chemotactic activity for eosinophils was detected in soluble egg antigen (sea) preparations of both schistosoma japonicum and s. mansoni in dose-dependent fashion. the activity of s. japonicum sea was higher than that of s. mansoni sea. gel filtration on sephadex g-150 showed that s. japonicum sea was composed of two groups of eosinophil chemotactic factors (ecfs), one of high molecular weight (jee-h) and the other of low molecular weight (jee-l). s. mansoni sea showed ecf compositio ...19836682296
the measurement of ascaris suum protein by radioimmunoassay in sera from patients with helminthiasis and with gastrointestinal diseases.in this study, we have developed a reliable radioimmunoassay (ria) for ascaris suum protein (asp) and have measured the serum concentration of asp in control subjects and in patients with helminthiasis and a variety of gastrointestinal diseases. the cross-reactivities of asp antibody with other helminth worm antigens were also measured by ria. ascaris lumbricoides contained approximately the same amount of asp antigenic substance as did ascaris suum. toxocara canis had a high concentration of a ...19836682964
competitive radioimmunoassays using hybridoma and anti-idiotype antibodies in identification of antibody responses to, and antigens of, schistosoma japonicum.a hybridoma-derived monoclonal antibody, i.134, with apparent specificity for schistosoma japonicum adult worms has immunodiagnostic potential for schistosomiasis japonica in the philippines. sera from known infected individuals will inhibit the binding of 125i-labelled i.134 to a crude adult worm extract (awe) in a competitive radioimmunoassay (cria), although a 10% false negative rate has been noted. another monoclonal antibody, p.41, which produces circumoval precipitation (cop) reactions wit ...19836683499
reduce embryonation of schistosoma japonicum eggs as a contributory mechanism in modulation of granuloma in chronically sensitized mice. 19836685346
a minimum essential medium for cultivation of schistosoma japonicum eggs. 19836686980
[extraction, fractionation and chemical and immunological properties of urea-soluble schistosoma japonicum egg antigen]. 19836687215
[enzyme-linked circumoval precipitation technic (elcopt) in the diagnosis of schistosomiasis japonica]. 19836687217
[effect of levamisole on the granulomatous response to schistosoma japonicum eggs in mice]. 19836687218
[artificial induction of specific immune modulation on schistosoma japonicum egg granulomas]. 19836687219
mechanism of action of praziquantel on the eggs of schistosoma japonicum.the mode of action of praziquantel on schistosoma japonicum eggs was examined in mice and in vitro. in a long term oogram observation of mouse intestine, lasting from 1 to 56 days after oral administration of 100 mg/kg 4 times in one day, many empty egg shells were observed from the next day. immature eggs, however, were not killed, but developed into miracidia that later degenerated into granulated and calcified eggs. in the oograms of mouse, from 5 to 240 minutes after a single oral dose of 10 ...19836687311
schistosoma mansoni, s. haematobium, and s. japonicum: identification of genus-, species-, and gender-specific antigenic worm glycoproteins.immunoreactive glycoproteins of schistosoma mansoni, s. haematobium, and s. japonicum adult worms which are genus-, species-, and gender-specific, or react with sera of patients infected with other parasites, have been identified. schistosomes were metabolically labeled with [35s]methionine and the concanavalin-a binding glycoproteins that were immunoprecipitated with sera of patients infected with one of three species of schistosoma or trichinella spiralis, taenia solium, echinococcus granulosu ...19846692879
schistosoma mansoni: detection and characterization of schistosome derived antigens by inhibition enzyme-linked immunosorbent assay (ielisa) utilizing monoclonal antibodies.monoclonal antibodies were used in an inhibition enzyme-linked immunosorbent assay (ielisa) to detect a variety of schistosome derived antigens. preparations were obtained from various stages of schistosoma mansoni and from the eggs of s. japonicum. using appropriate titers of monoclonal antibodies it was possible to detect less than 0.01 micrograms/ml of schistosome antigens. the sensitivity of ielisa was dependent upon the type and concentration of the monoclonal antibody used, as well as upon ...19846695533
depressed in vitro and in vivo antibody response and adoptive transfer of delayed hypersensitivity to myoglobin with spleen cells of mice chronically infected with schistosoma japonicum and injected with myoglobin.spleen cells from c57bl/6j mice infected for 21 weeks with schistosoma japonicum did not show an in vitro secondary antibody response upon challenge with sperm whale myoglobin. mice infected for 13 weeks showed almost no in vivo secondary antibody response to this antigen. spleen cells from mice infected for 12 to 21 weeks did not adoptively transfer delayed hypersensitivity to this antigen.19846698605
demonstration of species-specific and cross-reactive components of the adult microsomal antigens from schistosoma mansoni and s. japonicum (mama and jama).analysis of human serum reactivities to the schistosoma mansoni adult microsomal antigens (mama) showed that s. japonicum and s. haematobium infection sera, as a rule, did not react as well to mama as did the homologous s. mansoni infection sera. the degree of species specificity, although not absolute, was quite pronounced. purification of the corresponding microsomal antigens from s. japonicum adults (jama) and subsequent assays with both homologous and heterologous infection sera show a disti ...19846715885
[a comparison of the superficial argentophilic structures of miracidia from 12 species of the genus schistosoma].observation of miracidia of twelve species of schistosoma shows the fundamental epidermal cell pattern is: 6, 9, 4, 3. comparison of superficial argentophilic organites permits us: --to divide these species into three inequal groups: mansoni group: schistosoma mansoni, s. rodhaini. haematobium group: s. haematobium, s. bovis, s. indicum , s. intercalatum, s. margrebowiei , s. mattheei, s. nasale and s. spindale . japonicum group: s. japonicum, s. incognitum . --to emphasize the relatively narrow ...19846721370
susceptibility of snail vectors to oriental anthropophilic schistosoma.laboratory experiments were carried out to study the susceptibility of snail vectors to oriental anthropophilic schistosoma. oncomelania hupensis hupensis was readily infected with the local strain of schistosoma japonicum (chinese strain), and also infected with s. japonicum (philippines strain). o.h. quadrasi was only susceptible to its s. japonicum (philippines strain). the oncomelania races were refractory to s. mekongi, s. japonicum-like species (malaysian strain). tricula aperta (beta race ...19846740384
[a seroepidemiological survey on schistosomiasis japonicum]. 19846744396
schistosomiasis: host-pathogen biology.schistosomes are helminths of the class trematoda that alternate generations, with a sexual phase in definitive mammalian hosts and an asexual phase in intermediate snail hosts. in humans, these blood flukes reside in the mesenteric and vesical venules. they have a life span of many years and daily produce large numbers of eggs, which must traverse the gut and bladder tissues on their way to the lumens of the excretory organs. many of the eggs remain in the host tissues, inducing immunologically ...19826750744
schistosome infections in humans: perspectives and recent findings. nih conference.approximately 200 million persons are infected with schistosomes. of those infected, a small proportion develop serious chronic disease, usually after years of intensive exposure and infection. schistosoma mansoni and schistosoma japonicum reside in the mesenteric veins and produce liver fibrosis, which results in portal hypertension and bleeding esophageal varices but little hepatocellular dysfunction. schistosoma haematobium resides primarily in the pelvic veins and produces mass lesions in th ...19826753683
schistosomiasis vaccination. historical development, present status and future prospects. 19806769643
[synthesis of a new schistosomicide s72014 and its homologs (author's transl)]. 19806779503
scanning and transmission electron microscopy of schistosoma japonicum egg shell. 19806780276
scanning electron microscopy of chinese (mainland) strain schistosoma japonicum. 19816785027
hybridoma-derived antibody with immunodiagnostic potential for schistosomiasis japonica.a murine hybridoma-derived antibody (iph.134) has been produced which has apparent high binding specificity for an extract of schistosoma japonicum adult worms. no binding was detected to extracts of s. japonicum eggs or to extracts from other adult trematodes (fasciola hepatica, paragonimus westermanii, clonorchis sinensis, and schistosoma mansoni) and several other helminths and protozoa. when sera from two series of s. japonicum-infected philippine patients (19 and 20 patients, respectively) ...19816789330
chronic cor pulmonale due to schistosoma japonicum infection. 19816791895
research on late stage schistosomiasis japonica immunology. 19816791897
immunoglobulin allotypes in filipinos. i lack of association between schistosoma japonica infection and immunoglobulin allotypes. 19816795284
characterization of the glycoprotein antigens which mediate the schistosoma japonicum circumoval precipitin reaction.the circumoval precipitin test is a serological test used for diagnosis of schistosomiasis japonica. soluble egg antigens of schistosoma japonicum block the formation of the circumoval precipitin by serum from infected humans. consequently, circumoval precipitin inhibition was used to monitor purification of the soluble egg antigens of s. japonicum. crude egg antigens were separated into protein and glycoprotein fractions by lectin chromatography on concanavalin a sepharose. the glycoprotein fra ...19816796517
[detection of circulating anodic antigen in patients of schistosomiasis japonica by reversed indirect hemagglutination test (author's transl)]. 19816805893
[long-term follow-up observations on 502 cases of schistosomiasis japonica treated by praziquantel]. 19826812909
adhesion-precipitation technic for schistosome cercariae recovery from natural waters. 19826817982
liver collagen synthesis and degradation in schistosomiasis. 19836825441
vaccination against bovine schistosomiasis japonica with highly x-irradiated schistosomula.cercariae of the chinese mainland strain of schistosoma japonicum were used. eighteen cattle, divided into six groups of three each, were immunized with schistosomula transformed from cercariae exposed to three different doses of x-irradiation (24, 36, and 48 kr). the immunization was given either once, twice, or thrice, and the number of immunizing schistosomula was 10,000 or more in each immunization. the immunized cattle were challenged with 500 normal cercariae. five native cattle were simil ...19836837845
schistosoma japonicum: immunological response to circulating polysaccharide antigens in rabbits with a light infection.to study the detectability of circulating polysaccharide antigens and the immunological response to such antigens in rabbits with a light schistosoma japonicum infection, sera of five rabbits infected with 50 cercariae were studied up to 29 weeks post infection (p.i.). while one rabbit developed no worm burden, the other rabbits developed low worm burdens (4 to 16 worms). in the sera of these rabbits, the only polysaccharide antigen demonstrable with immunoelectrophoresis (ief), was the circulat ...19836852173
[histological and histochemical changes of schistosoma japonicum and host liver caused by artemether]. 19836858697
[electron microscopic studies on the effect of nithiocyamine on schistosoma japonica]. 19836880755
purification and characterization of a high molecular weight eosinophil chemotactic factor from schistosoma japonicum eggs.a high m.w. eosinophil chemotactic factor (ecf-sje) was isolated and purified from a soluble egg antigen preparation (sea) of schistosoma japonicum by gel filtration on sephacryl s-200, anion-exchange chromatography on de52, and isoelectric focusing. ecf-sje had a m.w. of more than 900,000 and an isoelectric point of 4.1. it contained 40% (w/w) sugar residues and bound to concanavalin a (con a). the chemotactic activity of ecf-sje was heat stable (100 degrees c, 60 min) and resistant to pronase ...19826889620
new methods of purifying and identifying parasitic diagnostic antigens: a review of the systematic and quantitative approach with the schistosoma model.several antigen preparations intended for use in the serodiagnosis of schistosomiasis were reviewed. the efficacies of these antigens in terms of specific activities and cross-reactivities were compared. the idea of quantitation of the actual usable amount of antigens in various preparations was introduced. a systematic approach to the purification and identification of relevant antigens in the schistosoma system was discussed. use of the quantitative single-tube kinetic-dependent enzyme-linked ...19826890267
association between an hla haplotype and low responsiveness to schistosomal worm antigen in man.immune responsiveness to schistosomal worm antigen was investigated in the individuals infected with schistosoma japonicum by measuring the antigen-specific proliferative response of the peripheral t lymphocytes in vitro. out of 57 infected individuals, 10 (17.5%) were low responders, whereas 47 (82.5%) were high responders to this antigen. the strong association between the hla-aw24-bw52-dw12 haplotype and the low responder group was demonstrated. because the association of the low responder gr ...19806967941
quantitative aspects of the epidemiology of schistosoma japonicum infection in a rural community of luzon, philippines. who workshop.in a rural community on the island of luzon, philippines, the overall prevalence of schistosoma japonicum infection, based on stool examination performed by both a new modified quantitative thick smear and the merthiolate-iodine-formaldehyde concentration (mifc) technique, was 49.5% in a total study population of 755 persons. peak prevalence was observed in the 15-19-year age group, then decreased gradually. although the total egg output was highest in the 15-19-year age group, individuals with ...19806969135
thymocytotoxic autoantibodies found in mice infected with schistosoma japonicum.thymocytotoxic autoantibodies were demonstrated in sera of c3h/hejms, c57bl/6j, and ddy mice infected with 50 cercariae of schistosoma japonicum, using c57bl/6j thymocytes as target cells in the trypan blue dye exclusion test. kinetic study revealed that thymocytotoxic activity began to increase at week 6 of infection, reached a maximum at 8 weeks, and thereafter decreased gradually. thymocytotoxic antibodies had an optimal reactivity at 4 degrees c and were sensitive to 2-mercaptoethanol treatm ...19816972913
collaborative study on antigens for immunodiagnosis of schistosomiasis.eight research laboratories in europe and the united states of america were selected on the basis of having published data on schistosoma mansoni and s. japonicum antigens to participate in a study of various antigen/test combinations for immunodiagnosis of schistosomiasis. the serum bank consisted of 395 well documented sera from four endemic areas in brazil (2 areas), kenya, and the philippines. altogether, 21 s. mansoni and four s. japonicum antigen and immunoassay combinations were evaluated ...19826983926
studies on the host-parasite relationship of schistosoma japonicum in normal and immunosuppressed mice.infections of schistosoma japonicum were studied in mice which were immunosuppressed either by thymectomy and administration of antithymocyte serum or by treatment with hydrocortisone acetate. the relation of s. japonicum with the immunosuppressed host differed with that reported for schistosoma mansoni. the pathogenesis of the s. japonicum infection in the immunosuppressed host was less severe than that caused by s. mansoni, with respect to survival of, and hepatocellular damage to, the host. i ...19826984166
parasite-parasite interaction of salmonella typhimurium and schistosoma.the parasite-parasite interaction of salmonella and schistosoma was studied. salmonella typhimurium lt2 was found to associate in vitro with three human species of schistosoma: schistosoma mansoni, schistosoma haematobium, and schistosoma japonicum. genetic mutants of s. typhimurium were allowed to interact with ligatured and unligatured worms of s. mansoni in vitro. these studies were undertaken to elucidate the mechanism(s) of the parasite-parasite interaction of salmonella on the surface of s ...19806988520
vaccination against schistosomiasis. 19807010375
[indirect hemagglutination in the diagnosis of bilharziasis. comparison with indirect immunofluorescence in the study of 3624 human serums]. 19807014010
preliminary application of a formalin fixed tissue section to the indirect fluorescent antibody test and intraoval precipitin reaction for the diagnosis of schistosomiasis japonica. 19807019527
cercaria dermatitis. 19817021623
schistosoma japonicum soluble egg antigens: separation by can a chromatography and immunoaffinity purification. 19817022162
acid protease in adult schistosoma japonicum (formosan strain).acid protease in schistosoma japonicum (formosan strain) was found. the isoelectric point of the enzyme was found to be 4.4 and 6.0 by the isoelectrofocusing technique and the molecular weight was estimated to be about 31,000 daltons determined by sephadex gel filtration. the km of the enzyme for human globin was found to be 2.9 x 10(-4) m.19817026189
[human schistosomiasis due to schistosoma mansoni, s. haematobium and s. japonicum. serological diagnosis by elisa, immunofluorescence and indirect hemagglutination]. 19817032429
schistosomiasis: clinical features and relevance to hematology. 19827041263
schistosoma japonicum: immediate hypersensitivity reactions to egg antigen in humans and rodents. 19827047199
adoptive transfer of modulation of granuloma formation and hepatosplenic disease in murine schistosomiasis japonica by serum from chronically infected animals.the course of disease due to schistosoma japonicum in c57bl/6j mice was examined. animals infected with 25 cercariae of the philippine strain of s. japonicum for 9 wk develop a peak portal hypertension of 13 +/- 0.6 cm h2o and mean hepatic granuloma area of 459 x 10(3) micrometers 2. by 30 wk, disease manifestations were reduced; mean portal pressure was 7 +/- 0.5 cm h2o and mean hepatic granuloma area was 12 x 10(3) micrometers 2. adoptive transfer of serum but not 1 x 10(8) spleen or 4 x 10(7) ...19827057037
correlation between lipid partition coefficients and surface permeation in schistosoma japonicum.comparison of transintegumental membrane permeability and partition coefficients of selected nonelectrolytes was attempted to correlate the parameters of lipid solubility, hydrophilicity, and membrane permeation in male and female schistosomes (parasites of the portal venous tributaries of man). surface permeation (measured by the triple isotope technique) and octanol/water partition coefficients were determined for 17 compounds (acetamide, aminopyrine, antipyrine, benzyl alcohol, butanol, caffe ...19827057454
hepatic calcification in schistosomiasis japonica. 19827069015
plasma spectrometric analysis for na, k, ca, mg, fe, and cu in schistosoma mansoni and s. japonicum.the concentration of k, na, ca, mg, fe, and cu in adult schistosoma mansoni and s. japonicum was determined using plasma spectrometric analysis. there was no difference in elemental composition of schistosoma mansoni pairs that were incubated in various media such as rpmi/1640, eagle's medium or hanks' balanced salt solution. these values were also equivalent to those obtained from worms directly extracted with 2% hcl. female worms of both species contained a relatively higher concentration of f ...19827077448
metabolic requirements of schistosomes.in adult schistosoma mansoni and s. japonicum carbohydrate utilization, formation of lactic acid and atp levels were the same under aerobic and anaerobic conditions. therefore, these parasites exhibited no pasteur effect. when the metabolic requirements of the parasites were raised by 5-hydroxytryptamine-(5-ht)-induced stimulation of the worm's motor activity, aerobic conditions did not reduce the rate of carbohydrate utilization nor the atp levels of the worms. therefore, these parasites do not ...19827077454
schistosoma japonicum in rabbits: differences in the host-parasite relationship over a seven-year period.rabbits were infected with schistosoma japonicum of japanese origin between 1973 and 1979. the distribution of lesions and eggs in the small intestine and colon changed significantly twice during that period, and the number of eggs per worm pair passed in the feces changed at least once. the shift in egg distribution and that in egg passage occurred at different times and appeared not to be causally related. the number of eggs per worm pair retained in the tissues of chronically infected rabbits ...19827081545
a rapid method for the infection of laboratory mice with schistosoma japonicum.known numbers of medium-suspended cercariae of schistosoma japonicum were injected either intraperitoneally, subcutaneously, intramuscularly or intravenously into mice and were compared for infectivity with s. japonicum cercariae that had been administered percutaneously. the injected cercariae appeared to be no less infective or fecund even after their maintenance in vitro for up to six hours. the intraperitoneal route of inoculation was preferred as it facilitated the rapid infection of mice a ...19827101404
eradication of schistosomiasis. 19827102873
control of schistosomiasis japonica in the nagatoishi area of kurume, japan.a pilot experiment using napcp as a molluscicide to control schistosomiasis japonica was initiated in 1950--51 in nagatoishi-cho, kurume, japan, where 1,050 persons lived behind dikes built to prevent flooding from the chikugo river. they farmed 60 ha of rice, and 72.9% of them were infected with schistosomiasis. at the end of 2 years, 99.5% of the snails (oncomelania h. nosophora) were controlled and new cases dropped from 30--35 per year to 5 and 0 at the end of the 1st and 2nd year, respectiv ...19827102909
further studies on the susceptibility of new taiwan foci of oncomelania hupensis to geographic strains of schistosoma japonicum.two known colonies of o.h chiui in alilao and of o.h. formosana in changhua and four new foci of snails in nantou, chiayi, hualien and taitung on taiwan were exposed each to 5 miracidia of changhua zoophilic strain and chinese, philippine and indonesian anthropopilic or human strains of s. japonicum. the results showed that all four new foci demonstrated various degrees of susceptibility to this parasite. infectivity of chinese strain of s. japonicum in 4 new foci of snails is reported for the f ...19827112218
serologic responses to schistosoma japonicum: evaluation of total and parasite-specific immunoglobulins during the course of murine infection.mice with a primary infection of schistosoma japonicum develop high levels of both total immunoglobulins and parasitic-specific antibodies, beginning about 1.5 wk after the onset of oviposition in the host. radial immunodiffusion demonstrated an 18-fold, fivefold, and threefold increase in the levels of igg1, igm, and iga, respectively, during the course of infection. schistosoma japonicum-specific antibodies, as measured by an enzyme-linked immunoabsorbent assay, appeared and increased at about ...19827119981
parasitological and pathological findings in capuchin monkeys infected with schistosoma japonicum or schistosoma mansoni.capuchin monkeys were studied for 7 months after exposure to schistosoma mansoni or to either a japanese or a philippine strain of schistosoma japonicum. the number of eggs present in the tissues and passed in the feces of s. mansoni-infected monkeys correlated well with the number of worm pairs recovered. monkeys infected with the philippine strain of s. japonicum passed large numbers of eggs in the feces and the number of these eggs correlated well with the number of worm pairs present. in mon ...19827125064
[development of schistosoma japonicum in the intermediate host oncomelania hupensis hupensis snail]. 19827126136
comparison of recovery of schistosomula of schistosoma japonicum from lungs of mice and rats.various strains of mice and rats were exposed to small doses of schistosoma japonicum cercariae. at intervals, they were challenged with 200 to 230 cercariae per mouse and 500 to 520 cercariae per rat. age-matched control animals received only the challenge infection from the same pool of cercariae. recoveries of schistosomula from experimental and control groups were different on day 3 through day 5, with peak recovery on day 3 or 4 in four strains of mice examined (dba/2, c57bl/6, c3h/he, and ...19827131184
isolation of a concanavalin a-binding glycoprotein from adult schistosoma japonicum. 19827131202
population studies on oncomelania quadrasi, the snail intermediate host of schistosoma japonicum, in the philippines. 3. data transformation for significance test of snail density.for the comparative study of densities of oncomelania quadrasi, the snail intermediate host of schistosoma japonicum in the philippines, the survey data should be transformed to stabilize the variance in determining the significant difference of densities among populations and to evaluate control measures by the difference, since the snail is distributed unevenly in the field. comparison was made for the efficiency of stabilizing variance among 7 transformation formulas so far reported, and 2 ne ...19827131853
resistance of mice to secondary infection with schistosoma japonicum, with special reference to neutrophil enriched response to schistosomula in the skin of immune mice.the lung recovery assay for schistosomula has been used as a rapid method for measuring acquired resistance to schistosoma mansoni infection in challenged animals. this assay method was successfully utilized in the present study with s. japonicum in mice. assay of resistance to reinfection with the lung recovery technique and with the conventional perfusion method demonstrated that a considerable level of resistance developed in mice which had received the primary infection of 30 s. japonicum ce ...19827131856
morphological alterations of schistosoma japonicum associated with the administration of amoscanate.morphological alterations of schistosoma japonicum induced by the administration of a curative dose (20 mg/kg) of the schistosomicide, amoscanate (4-isothiocyanate-4'-nitrodiphenylamine, cgp4540), were studied. worms from amoscanate-treated ddy mice exhibited remarkable changes on the surface of male and female worms, as well as in the vitelline cells of females. various types of lesions, such as swelling and ballooning of the tegument, constriction of folds and channels, disruption of sensory r ...19827131858
enzyme-linked immunosorbent assay with egg antigens of schistosoma japonicum.a micromethod of the enzyme-linked immunosorbent assay (elisa) was applied to infections with schistosoma japonicum in humans and mice with egg antigens. in mouse infections, antibody responses were detected between 6 and 8 weeks after the cercarial challenge. in human infections, a circum oval precipitin positive group showed the highest reaction values in elisa. elisa with egg antigens did not show any cross reaction with sera of humans infected with intestinal parasites (ascaris, trichuris an ...19827136190
isolation of schistosoma japonicum egg glycoprotein antigens which sensitize mice to lung granuloma formation and elicit an immediate hypersensitivity response.crude schistosoma japonicum soluble egg antigen (sea) could be resolved into at least 25-30 coomassie blue-reactive polypeptides when subjected to polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. two of these polypeptides also gave a strong reaction for carbohydrate with the periodic acid-schiff (pas) reagent. although only four antigens could be demonstrated by double immunodiffusion in agar against the sera of mice with a 9-week s. japonicum infection, double antib ...19827149104
[study on fragility of mast cells in skin tissue in mice infected with schistosoma japonicum]. 19827150000
lung granulomatous hypersensitivity to eggs of schistosoma japonicum in mice analysed by a radioisotopic assay and effects of hybridoma (idiotype) sensitization.the radioisotopic assay for acute granulomatous hypersensitivity (agh) to eggs of schistosoma japonicum in mice sensitized with eggs in adjuvant has been examined in the high responder strain. c57bl/6. responsiveness is expressed as the lung-kidney ratio of radioactivity in mice challenged intravenously with eggs and injected with 125i-iododeoxyuridine. eggs vary in their agh sensitizing and eliciting potency; eggs proven to be superior in the circumoval precipitation (cop) test for detection of ...19827150121
[phenithionate(phenyl-4-nitrodiphenylamine-4'-thionocarbamate) in the treatment of schistosomiasis japonicum--a preliminary report on 463 cases]. 19827151549
[the in vitro effect of agrimophol on schistosoma japonicum]. 19827158350
[sythesis and antischistosomal action of phenithionate and related derivatives of thiocarbamic acid]. 19827158351
an epidemiological study on schistosoma japonicum in domestic animals in leyte, philippines.an epidemiological study of schistosoma japonicum in domestic animals in two municipalities of the eastern coastal plain of leyte, philippines, showed that pigs and dogs have the highest rates of prevalence. dogs had the highest mean 24-hour egg output, and pigs the proportion of hatchable eggs. however, dogs serve an important role in maintaining the transmission of the parasite as indicated by a high transmission potential and the close habitual contact of the animals to human. although necrop ...19827170639
studies on the susceptibility of new taiwan foci of oncomelania hupensis to ilan and japanese strains of schistosoma japonicum.sixty snails from four new foci of o. hupensis in taitung, chiayi, hualien and nantou counties, and 4 known colonies of o. h. chiui in alilao and pali in taipei as well as of o. h. formosana in changhua and ilan on taiwan were exposed each to 5 miracidia of ilan zoophilic strain and japanese anthropophilic or human strain of s. japonicum. this is the first report to note that all four new foci of o. hupensis snails were highly susceptible to ilan strain of s. japonicum (17-20%). susceptibility t ...19827170640
malignant schwannoma occurring with schistosoma japonicum: a case report.an 18-year-old filipina presented with a 28 cm retroperitoneal malignant schwannoma arising from the sigmoid colon. histopathologic examination revealed the presence of numerous schistosome ova immediately adjacent to the tumor and throughout the submucosa. due to the rarity of malignant schwannomas, their infrequent occurrence in young persons in the absence of von recklinghausen's neurofibromatosis, and the presence of schistosomal ovideposition, the possible role of schistosomal infection in ...19827170642
protein, glycogen, and water content in schistosomes.the volume of distribution (= vd) of water was measured in schistosoma mansoni, s. haematobium, s. japonicum, and hymenolepis diminuta. in the rat tapeworm, h. diminuta, the volume of distribution of 3h-water was positively correlated with wet weight (r = 0.87, p less than 0.001) and this same phenomenon also was demonstrated in s. mansoni (r = 0.90, p less than 0.001). the 5-sec vdwater was constant over a range of glucose (0.01-50 mm) and phenylalanine (0.01-20 mm) concentrations in both male ...19827175609
population studies on oncomelania quadrasi, the snail intermediate host of schistosoma japonicum, in the philippines. 4. evaluation of drainage for snail control. 19827176144
schistosoma japonicum: migration of adult worm pairs within the mesenteric veins of mice.mice infected with a single worm pair of a japanese, a philippine and a formosan strain of schistosoma japonicum were examined to determine the frequency of movement of worms within the mesenteric veins eight to 76 weeks after infection. by the 18th week after infection, one or more gross focal lesions developed in the gut, and 47 to 89% of eggs in the gut were concentrated in these lesions. in spite of this predominantly focal oviposition, oograms revealed first-stage eggs scattered throughout ...19827179417
[scanning electron microscope observations on tegumental surface alterations of schistosoma japonicum induced by pyquiton]. 19827180480
[comparison of the cercarial chaetotaxy of 10 species of schistosomes].the cercarial chaetotaxy permits the differenciation of four groups of schistosomatinae. --schistosomatium douthitti, parasite of stagnicola and lymnaea (lymnaeidae); --schistosoma japonicum, parasite of oncomelania (melaniidae); --schistosoma mansoni and s. rodhaini, parasites of biomphalaria (planorbiinae, bulinidae); --schistosoma haematobium, s. bovis, s. margrebowiei, s. mattheei, s. leiperi and s. intercalatum, parasites of isidora, physopsis and bulinus (bulininae, bulinidae). for the thi ...19827181377
[observation of various immunological indices in 207 patients with schistosomiasis]. 19827182137
a study of ultrastructure of egg shell of schistosoma japonicum. i. transmission electron microscopic observation of s. japonicum egg.ultrathin sections of egg shell of s. japonicum were observed. the micropores and network of microcanals were first reported in egg shell of s. japonicum. both the micropores and microcanals are lined by a membrane being continous with the inner layer of egg shell and filled with materials coming from inside of the egg. as in the egg of s. mansoni, the possibility of micropores and microcanals that may play an important role as natural channels in secreting materials such as soluble antigens and ...19827187198
[superficial argyrophilic structures of the infective larval forms of schistosoma japonicum].integumentary argentophilic structures in miracidium and cercaria of schistosoma japonicum, chinese strain, are described in detail. - miracidium. the pattern of organites between the first and second tier and between the second and third tier in miracidia of s. japonicum is identical to that in miracidia of s. incognitum, but differs from that seen in miradicia of other species of schistosoma. - cercaria. chaetotaxy differs from that reported in a previous study but, in our opinion, these diffe ...19827187199
"control of schistosomiasis": morbidity-reduction and chemotherapy. 19827188153
epidemiology of schistosomiasis. 19827188157
circulating antigens in schistosoma-infections. 19827188159
schistosomiasis japonica in barrio san antonio, basey, samar in the philippines. iv. "atypical" precipitates in the circumoval precipitin test--a reaction of recent infection.morphologically distinct circumoval precipitin reactions, not having the usual "segmented" appearance, are characteristic of recently acquired infection of man with schistosoma japonicum. in contrast to the precipitins seen in plasma of those with chronic infections, reactions of recent infection (rri) are commonly, large, vacuolated blebs or, if elongate, are smooth and vacuolated in structure. recognition of these rri provides a practical, simple method to study incidence of infection and the ...19807189969
hepatic fibrosis in rabbits infected with japanese and philippine strains of schistosoma japonicum.symmers' clay pipestem fibrosis of the liver was produced by schistosoma japonicum infection in the rabbit. gross and microscopic portal fibrosis and portal vascular lesions resembled those in hepatosplenic schistosomiasis in man. portal obstruction caused dilation of portal-systemic collateral veins but only minimal portal hypertension. the rapidity of development and prevalence of symmers' fibrosis were related to the intensity of the schistosome infection. a mixed macronudular and micronodula ...19807192497
the effect of praziquantel on schistosoma haematobium, s. japonicum and s. mansoni in primates.baboons infected with s. haematobium and vervet monkeys infected with s. japonicum were treated orally with different dosage regimens of 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino[2,1-a]isoquinolin-4-on e(praziquantel, embay 8440, biltricide) and were autopsied and perfused 3--4 months after treatment. the results suggest that a single oral dose of 75--100 mg/kg body weight is likely to be effective against s. haematobium in the baboon. female worms of s. haematobium are apparently ...19817195244
schistosoma species: transmission electron microscopy of the circumoval immune precipitin reaction on eggs. 19817195345
influence of temperature on the antigenicity of schistosoma japonicum lyophilized eggs for circumoval precipitin test (copt). 19807195954
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