| inactivation of phages ds6a and d29 by acetone extracts of mycobacterium tuberculosis and mycobacterium bovis. | the adsorption rate constant for mycobacteriophage ds6a on clumped cells of mycobacterium tuberculosis strain h37rv was found to be 6.33 x 10(-13) ml per min per colony former. acetone-extracted cells of h37rv did not absorb phage ds6a. acetone extracts of cells of h37rv and of mycobacterium bovis strain bcg inhibited plaque formation of mycobacteriophage ds6a and of phage d29. suspensions of these extracts in heart infusion broth with 0.002 m calcium chloride and 1 per cent dioxane required 20 ... | 1975 | 807139 |
| failure of isoniazid prophylaxis after exposure to isoniazid-resistant tuberculosis. | we report the failure of isoniazid chemoprophylaxis to prevent the development of active pulmonary tuberculosis and tuberculin conversion in contacts of patients infected with isoniazid-resistant strains of mycobacterium tuberculosis. although failure of isoniazid chemoprophylaxis has been reported rarely in contracts of isoniazid-resistant tuberculosis, the cases reported here as well as previous observations by others suggest that isoniazid chemoprophylaxis for contracts of patients with isoni ... | 1975 | 807140 |
| tuberculin-induced lymphocyte transformation and skin reactivity in monkeys vaccinated or not vaccinated with bacille calmette-guérin, then challenged with virulent mycobacterium tuberculosis. | the in vitro lymphocyte transformation test was compared to the skin test at intervals after aerogenic administration of bacille calmette-guerin vaccine to monkeys, and also at monthly intervals after aerogenic challenge of monkeys vaccinated and not vaccinated with virulent strain h37rv of mycobacterium tuberculosis. individual responses varied, but several consistent patterns of sensitivity development could be discerned. the lymphocyte transformation test was more sensitive, and often positiv ... | 1975 | 807141 |
| the participation of common and species-"specific" antigens of mycobacteria in the tuberculin skin reaction. | protoplasmic extracts isolated from four different species of mycobacteria contained common and species-specific antigens. both the common and the specific antigens were involved in the elicitation of the tuberculin reaction in sensitized guinea pigs. the elimination of the common antigens from the extracts by means of cross absorption with heterologous mycobacterial antibodies led to preparations which, at the doses used in this study, elicited a cutaneous reaction in animals sensitized with th ... | 1975 | 807305 |
| [bacteriostatic and bacteriacidal activity of hydroxy-9 ellipticine in vitro]. | 9-hydroxy-ellipticine shows a clear effect against bacterial development. this effect depends essentially upon the bacterial species. two groups can be differentiated: group i with resisting species composed by negative gram bacilli (enterobacteria and pseudomonas); group ii with sensitive species formed by coccus, positive gram bacilli, mycobacterium tuberculosis and anaerobes. | 1975 | 807356 |
| tuberculous meningitis developing after six months of treatment of pulmonary tuberculosis. complication of infection with a drug-resistant strain in a two-year-old child. | | 1975 | 807448 |
| [comparative dose-effect relationship of a tuberculin standard on guinea pig sensitivity, using living and dead tuberculosis bacilli]. | the sensitization of guinea pigs utilized for tuberculin titration may be obtained by a bcg primo-vaccination followed by an inoculation of live, virulent myc. tuberculosis. this method, which results in a sub-evolutive form of tuberculosis, gives a satisfactory sensitization level but has the disadvantage of utilizing animals which are germ carriers and therefore dangerous. a method has been tested employing killed germs (jamaica strain) coated with freund's complete adjuvant h37ra which utiliz ... | 1975 | 807493 |
| [principles of the antitubercular therapy]. | | 1975 | 807497 |
| seasonal variation of induction of contact sensitivity and of lymph node t lymphocytes in guinea pigs. | guinea pigs sensitized with dinotrophenyl thiocyanate in complete freund's adjuvant from november to february developed markedly lower contact sensitivity than animals sensitized during the rest of the year. the percentage of t cell rosettes (lymphocytes forming spontaneous rosettes with normal rabbit red cells) was concomitantly reduced in the lymph nodes but not in thymus or bone marrow during the winter months. | 1975 | 807531 |
| multiple skin testing in leprosy. | groups of patients with lepromatous and tuberculoid leprosy and hospital staff from six leprosaria in east africa and 'non-contact' groups of villagers or staff from general hospitals have been skin tested with 10 reagents. these were prepared by ultrasonic disintegration from m. tuberculosis, m. duvalii, m. chelonei and 7 other species identified in the ugandan environment. comparisons were made of the percentages of positive reactors in each study group for each reagent. the 'specific' defect ... | 1975 | 807619 |
| phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. reversal of the usual nonfusion pattern and observations on bacterial survival. | tubercle bacilli of the pathogenic human strain h37rv had previously been shown to multiply, after ingestion by cultured mouse peritoneal macrophages, within phagosomes that tended to remain unfused with secondary lysosomes. means were sought therefore for promoting experimentally a modification of the host response so as to attain a high level of phagolysosome formation, enabling tests to be made of any effects on the course and outcome of the intracellular infection. this was achieved by expos ... | 1975 | 807671 |
| tuberculous meningitis in children during the isoniazid era. | fifty-nine cases of tuberculous meningitis in children seen at the charity hospital at new orleans since the addition of isoniazid to the therapy in 1952 are reviewed. fourteen of the children died during hopsitalization. at discharge 21 children had complete or nearly complete clinical recovery. follow-up of 21 available long-term survivors revealed a significant number with neurologic and social disabilities. the endemicity of tuberculous infections in the households of the children and factor ... | 1975 | 807696 |
| chemical constituents of gentianaceae xvi: antitubercular activity of xanthones of canscora decussata schult. | | 1975 | 807707 |
| inhibition of the primary lesion of adjuvant. induced polyarthritis in rats (18-hour arthritis test) for specific detection of clinically effective anti-arthritic drugs. | adjuvant-induced polyarthritis can be induced in rats 14 to 21 days after subplantar injection of 0.1 ml of a 0.5% suspension of mycobacterium tuberculosis in heavy mineral oil into a hind paw. however, edema volume of the injected pay (primary lesion) developed rapidly and reached a peak in 18 hours after injection and persisted at this level for up to 90 hours. a single oral dose of 25 clinically effective or experimental antiarthritic agents given 1 hour prior to m. tuberculosis injection and ... | 1975 | 807714 |
| growth inhibition of tubercle bacilli after pulsed exposures to combinations of antituberculous drugs. | all possible pairs of drugs chosen from the primary antituberculous agents including isoniazid, streptomycin, rifampin, and ethambutol were compatible and inhibited growth after administration to tubercle bacilli in a single 7 hr pulsed exposure. in general, combined drug effects could be best described as additive. | 1975 | 807961 |
| [mycobacteria]. | a brief review is presented of those properties of mycobacteria (genus mycobacterium) which have a bearing on human medicine. the properties are set out in the form of tables covering the important cultural and biochemical tests used in taxonomy, resistance vs. sensitivity to a range of antituberculous drugs, and virulence and pathogenic effect in man and laboratory animals. | 1975 | 807970 |
| experimental male genital tuberculosis-appraisal of protective value of bcg vaccination. | as part of an experimental study of the spread of urogenital tuberculosis, the development of tuberculous infection was compared in vaccinated and non-vaccinated guinea pigs after challenge with mycobacterium tuberculosis strain h37rv into the seminal vesicle. the animals were saccrified 35 days after challenge. morphological observations indicate that tuberculous infection in an immunized animal is retarded, but spreads by the same routes as in an nonimmunized animal. on microbial enumeration s ... | 1975 | 808092 |
| infection of microtus arvalis (common vole) with mycobacterium tuberculosis and mycobacterium bovis. | the aim of the study has been to ascertain whether microtus arvalis (common vole) is strongly susceptible to m. bovis but resistant to m. tuberculosis, as is the case with other members of the vole family, or whether it is susceptible to both species as demonstrated by robert koch. groups of common voles have been injected subcutaneously or intraperitoneally with varying doses of finely dispersed suspensions of a virulent strain of m. bovis or m. tuberculosis. m. bovis multiplies strongly in the ... | 1975 | 808093 |
| bacteraemia in red mice (clethrionomys g. glareolus schreb.) after intraperitoneal injection of large doses of tubercle bacilli. | römer (1903) has demonstrated that white mice injected intraperitoneally with large doses of tubercle bacilli isolated from man survived longer than mice injected with tubercle bacilli isolated from cattle. the blood of the spontaneously dead animals contained large numbers of tubercle bacilli. in the present study, red mice are injected intraperitoneally with 10 mg doses of different species of mycobacteria, and the number of bacilli in the blood is estimated at various intervals within the fir ... | 1975 | 808094 |
| the structure of mononuclear phagocytes differentiating in vivo. ii. the effect of mycobacterium tuberculosis. | the development and resolution of granulomas induced by mycobacterium tuberculosis were sequentially traced by correlated light and electron microscopy. the scattered, immature monocytes initially composing the lesions evolved by orderly steps into coalescent, well developed macrophages and ultimately into swirling nests of highly complex epithelioid cells. these ultrastructural changes represent differentiation in vivo of the mononuclear phagocytes. the number of mycobacteria present than wa ... | 1975 | 808135 |
| tuberculin and histoplasmin sensitivity in six solomon islands populations. | skin testing with antigens from histoplasma capsulatum, mycobacterium tuberculosis (ppd-s), and atypical mycobacteria (ppd-b, ppd-g, ppd-y, and ppd-platy) was carried out among six population groups in the solomon islands between 1968 and 1972. there was no positive reaction to histoplasmin among any of the groups, suggesting that histoplasmosis is not endemic in the solomon islands. there were significant numbers of tuberculin reactors among each group. largest mean reactions to ppd-s were pres ... | 1975 | 808143 |
| [a contribution to the problems of the tuberculous focus in lung after an antituberculotic treatment (author's transl)]. | | 1975 | 808254 |
| [the influence of sodium pyruvate on the isolation sensitivity and on contamination of the löwenstein-jensen media (author's transl)]. | | 1975 | 808255 |
| tuberculosis: the new challenge to the practicing clinician. | | 1975 | 808400 |
| [incidence and clinical significance of visible but not viable bacilli in patients with pulmonary tuberculosis]. | | 1975 | 808444 |
| [in vitro studies on the mechanisms of acquired resistance to tuberculous infection (author's transl)]. | | 1975 | 808464 |
| chemical studies on tuberactinomycin. viii. isolation of tuberactinamine n, the cyclic peptide moiety of tuberactinomycin n, and conversion of tuberactinomycin n to o. | tuberactinamine n, the cyclic peptide moiety of tuberactinomycin n, was obtained in a crystalline state through liberation of gamma-hydroxy-beta-lysine from tuberactinomycin n by acid treatment. tuberactinamine n possesses an intramolecular hydrogen bond in its molecule and showed antibacterial activities comparable to those of the original antibiotics. conversion of tuberactinomycin n to o was achieved through coupling of diacyl-beta-lysine with tuberactinamine n followed by removal of the pr ... | 1975 | 808523 |
| proceedings: relationships between chemical structure and biochemical activity of trehalose-6,6'-dimycolate (cord factor) of mycobacterium tuberculosis. | | 1975 | 808660 |
| atypical mycobacteria: a factor to consider in lung disease. | | 1975 | 808802 |
| [changes in the incidence of microscopically positive findings along with negative culture of m. tuberculosis in patients treated with rifampicin]. | | 1975 | 808808 |
| a historical basis for modern concepts of the pathogenesis of tuberculosis. | theories of the pathogenesis of tuberculosis accepted by clinicians in this field, receive no mention or little emphasis in textbooks of pathology. these are: the systemic character of the disease from the initial infection; the role of tissue allergy; the subclinical, benign and lifelong character of most tuberculosis infections, yet liable to an endogenous activation by the influence of stress. these concepts go far back in history, and reference is made to bayle (1816), koch (1891), calmett ... | 1975 | 808863 |
| the species distribution of three concanavalin a-purified mycobacterial polysaccharides. | culture filtrates prepared from 12 species of mycobacteria were examined for the presence of 3 mycobacterial polysaccharides previously purified by concanavalin a affinity chromatography. four commercial old tuberculins, tuberculin tine test units, and purified protein derivative were also studied. all 3 polysaccharides were demonstrated in all of the filtrates and each of the old tuberculins and purified protein derivative. the amount of concanavalin a-nonreactive polysaccharide was measured in ... | 1975 | 808990 |
| the indirect fluorescent antibody test for the detection of circulating antibodies in bovine tuberculosis. | indirect fluorescent antibody (ifa) tests were carried out on a total of 545 individual serums from beef cattle just before tuberculin testing, using specific fitc-anti-bovine igg and igm conjugates. phenol-killed m. tuberculosis (h37rv strain) or field strains of m. bovis and m. avium were used as antigenic substrates. all cattle were examined at abattoirs for the presence of tuberculous lesions. a statistically significant difference (p less than 0.001) was found between the number of cattle w ... | 1975 | 809031 |
| abdominal tuberculosis: demonstration of tubercle bacilli in tissues and experimental production of hyperplastic enteric lesions. | material obtained from 35 cases of abdominal tuberculosis waps studied and an attempt was made to demonstrate tubercle bacilli by special staining of histological sections, culture and guinea-pig inoculation. acid fast bacilli could be demonstrated in 80 per cent of cases. the remaining cases were also possibly due to tuberculous infection because granulomas with langhans's type of giant cells and caseation or calcification of lymph nodes were present. the bacilli were demonstrated in bowel tiss ... | 1975 | 809081 |
| [the influence of sodium pyruvate on the isolation sensitivity and on contamination of the löwenstein-jensen media (author's transl)]. | | 1975 | 809121 |
| the significance of isolating low numbers of mycobacterium tuberculosis in culture of sputum specimens. | because fewer than five mycobacterium tuberculosis colonies were isolated from single sputum specimens from several patients with little clinical evidence of pulmonary tuberculosis, we reviewed all of our low colony isolates (lcis) from an 18-month period. thirty-one patients had 35 lcis and were separated easily into groups that either appeared to have tuberculosis by clinical criteria or appeared to be uninfected. patients in the "tuberculosis likely" group reasons such as concurrent antituber ... | 1975 | 809251 |
| skin reaction, inhibition of macrophage migration, and lymphocyte transformation with tuberculin active peptide (tap) and arabinogalactan obtained from tubercle bacilli. | arabinogalactan purified from heat-killed tubercle bacilli failed to elicit a delayed type of skin reaction and had no ability to induce in vitro lymphocyte blast formation in sensitized guinea pigs. it was, however, inhibitory to migration of bronchoalveolar washing cells by the indirect test, but not by the direct test, and capable of eliciting an immediate type of skin reaction and anaphylaxis when injected into sensitized guinea pigs. tuberculin active peptide (tap) was active in all of in v ... | 1975 | 809364 |
| differentiation of known strains of bcg from isolates of mycobacterium bovis and mycobacterium tuberculosis by using mycobacteriophage 33d. | the use of mycobacteriophage 33d to differentiate strains of bcg from isolates of mycobacterium bovis was investigated. the procedure was found to be reproducible and, using the commercially available media described, can be recommended for use in mycobacterial reference laboratories. | 1975 | 809476 |
| use of cetylpyridinium chloride and sodium chloride for the decontamination of sputum specimens that are transported to the laboratory for the isolation of mycobacterium tuberculosis. | a method is presented for the decontamination, liquefaction, and concentration of sputum specimens that are in transport more than 24 h. the method is inexpensive, and culture results compare well with those obtained with the accepted n-acetyl-l-cysteine and sodium hydroxide method for the isolation of tubercle bacilli. the working solution, 1% cetylpyridinium chloride and 2% sodium chloride, is mixed in equal volumes with sputum before the specimens are shipped. tubercle bacilli remained viable ... | 1975 | 809478 |
| cervical mycobacterial infection. | | 1975 | 809520 |
| [genetics of mycobacterium]. | | 1975 | 809598 |
| the mode of action of immunological adjuvants. i. a new method to assess the adjuvant effect of substances as represented by mycobacterial adjuvants. | when mice were sensitized with sheep red blood cells (srbc), the addition of adjuvant-active substances to the sensitizing antigen resulted in a highly significant increase in the mean diameter of plaques developed by spleen cells as measured by jerne's plaque technique. the increase in plaque diameter was found to be a good measure for the adjuvant effect of such substances as mycobacterial adjuvants, because the phenomenon is specific, reproducible, sensitive and can be tested using a few numb ... | 1975 | 809606 |
| the mode of action of immunological adjuvants. ii. generation of a potent precursor of antibody-forming cell by adjuvant. | the mode of action of mycobacterial adjuvants was studied in mice, using a 'plaque size' technique and purified adjuvants, wax d and ad6. data were obtained which suggest that the adjuvants do not act directly on antibody-forming cells or memory cells but on their precursors. the injection of the adjuvants alone apparently caused the generation of competent precursor cells in the spleen as well as in the bone marrow of mice, which developed large plaques and the generation of memory cells develo ... | 1975 | 809607 |
| suppression of intracellular multiplication of mycobacterium tuberculosis by virus-inhibiting factor or interferon. | | 1975 | 809612 |
| modified eae as an assay for immunosuppressant drugs. | | 1975 | 809779 |
| [comparative values of live or killed bcg and trypsinized koch's bacillus in the immunization of zebu against tuberculosis]. | | 1975 | 809814 |
| [etiological diagnosis of spondylitis. ii. vertebral puncture biopsy and surgical approach]. | the authors tried to determine the ways in which vertebral puncture biopsy and the direct surgical approach can helpin the etiological diagnosis of spondylodiscitis, when the clinical radiological, and laboratory examination leave the clinician in doubt. out of 28 vertebral puncture biopsies, proof of tuberculosis was obtained in 4 cases, and proof of a non-tuberculous cause was obtained in 1 case as a result of isolating the responsible organism. thirty-eight cases were submitted to the direct ... | 1975 | 809831 |
| susceptibility of newborn and adult guinea pigs to mycobacterium intracellulare and m. kansasii. | six groups of guinea pigs, each consisting of 30 3-month-old and 20 7-day-old animals, received intraperitoneal inoculations with one of four strains of mycobacterium intracellulare or one of two strains of m. kansasii. three similar control groups received either an intraperitoneal injection of m. tuberculosis, no injection, or a sterile injection. guinea pigs were sacrificed at 3, 5, 10, 20, 30, and 90 days. lungs, spleen, liver and peritoneal fluid were cultured. lungs were also examined hist ... | 1975 | 809838 |
| [demonstration of tubercle bacilli in the parietal pleura]. | | 1975 | 809879 |
| [resistance of tuberculosis mycobacteria in raw-dried and raw-fumigated sausages]. | studied was the resistance of mycobacterium tuberculosis, mycobact. bovinum, and mycobact. avium in the nonperishable raw-dried and raw-fumigated saussages koprivshtenska and troyanska loukanka and gornooryahovskanadenitsa, produced according to the requirements of the bulgarian state standards and the technologic instructions. it was found that the viability and pathogenicity of the tuberculosis mycobacteria in the raw-dried loukankas persist up to the 180th day from contamination, and in the r ... | 1975 | 809903 |
| in vitro bacteriological study of a new antibiotic substance: sisomicin. | effects of a new antimicrobial agent sisomicin on microorganisms isolated from pathologic material (pseudomonas aeruginosa, staphylococcus aureus, serratia marcescens, klebsiella pneumoniae, salmonella spp., streptococcus pyogenes-b, citrobacter freundii) were studied. the results obtained were compared with another two aminoglycoside antibiotics - gentamicin and tobramycin. all three antibiotics were found to be very effective in vitro; their effect was enhanced by addition of an antibiotic of ... | 1975 | 809943 |
| [recent research on derivatives of 8-oxyquinoline. new 7-arylglyoxylidenehydrazinomethyl-8-oxyquinolines and 5-chloro-7-arylglyoxylidenehydrazinomethyl-8-oxyquinolines]. | | 1975 | 810149 |
| drug resistance in patients with pulmonary tuberculosis. | a review of the records of 984 patients admitted to hospital from 1970 through 1973 with bacteriologically proven pulmonary tuberculosis showed bacterial resistance to one or more antituberculosis drugs in 103 (10.5%). among the patients who had had previous drug treatment for tuberculosis the prevalence of drug resistance was 20% in the canadian-born patients and 69.4% in the recent immigrants. among the patients who had had no previous drug treatment the prevalence of drug resistance (primary ... | 1975 | 810238 |
| studies on antibacterial agents. iii. synthesis of n,n'-bis(4-quinolyl-4-quinaldinyl-, 4-quinazolinyl-, or 9-acridinyl)polymethylenediamines and their sulfonamides. | | 1975 | 810252 |
| [characteristics of mycobacteria isolated from diagnostic obtained from tuberculous patients in selected environments]. | | 1975 | 810393 |
| further studies on the effect of lung antibodies on the pathogenesis of tuberculosis. | a study was made to further clarify the role of lung reactive antibodies in tuberculous infection. following intravenous infection with viable tubercle bacilli, mice received mouse anti-mouse lung antibodies for three weeks. control groups consisted of tuberculous mice receiving non-lung antibody containing fluid and uninfected mice. a method was developed for quantitating tuberculous infection in these different groups by expressing the number of lesions produced per unit of cross-sectional sur ... | 1975 | 810530 |
| the mode of action of mycobacterial adjuvants. iii. the clonal nature of antibody formation and the effect of mycobacterial adjuvant on antibody-forming cell clones. | localization of 19s and 7s plaque forming cells detected by jerne plaque technique were examined in the spleens of irradiated recipient mice transferred with a limiting number of spleen cells and srbc. all the plaques within a single colony were homogeneous in size and appearance. this supports the clonal nature of antibody formation. an addition of a mycobacterial adjuvant, wax d, to the sensitizing antigen, srbc, caused an increase in the number of clones (colonies) developing large plaques. i ... | 1975 | 810609 |
| [rifampicin treatment for pulmonary tuberculosis--effectiveness of rifampicin on tubercle bacilli in pulmonary lesions (author's transl)]. | | 1975 | 810614 |
| [comparison between sm daily and twice weekly treatment in the regimen of sm, inh and pas--particularly considering the degree of drug resistance-- (report 1) (author's transl)]. | | 1975 | 810615 |
| [in-vitro potentiation of the anti-tuberculous effects of rifampicin and ethionamide by 4,4-diamino-diphenylsulphone (author's transl)]. | | 1975 | 810789 |
| [in-vitro study of the effects of 4,4-diamino-diphenylsulphone in combination with isoniazid and rifampicin (author's transl)]. | | 1975 | 810790 |
| [l-forms in the urine of patients with renal tuberculosis]. | | 1975 | 810792 |
| [action of mycobacteriophages in experimental tuberculosis]. | | 1975 | 810793 |
| [effect of mycobacteriophages on the course of experimental tuberculosis in albino mice]. | | 1975 | 810794 |
| [the antibiotic effect of the madder root (rubia tinctorium)]. | | 1975 | 810813 |
| [cases of detection of mycobacterium tuberculosis in patients with nonspecific diseases of the lungs]. | | 1975 | 810906 |
| resistance-enhancing compound from mycobacterium tuberculosis. | a soluble, high molecular weight, resistance-enhancing compound was isolated from mycobacterium tuberculosis by fractionation of a dimethylsulfoxide extract of the organism with n-decyl alcohol. the compound contained carbohydrate, protein, fatty acids, and phosphorous. resistance enhancement was nonspecific in that protection was afforded toward infection with klebsiella pneumoniae as well as m. tuberculosis. the compound enhanced the rate of clearance of carbon from the blood of mice and depre ... | 1975 | 811141 |
| immunoelectrophoresis of mycobacterium tuberculosis antigens. comparative analysis of cell extract and culture filtrate antigens. | immunoelectrophoretic analyses were performed on a cell extract and culture filtrate of mycobacterium tuberculosis, h37rv strain using homologous polyvalent goat antisera. general similarity between the cell extract and culture filtrate antigens was found. significant variation between two anti-culture filtrate antisera was observed. these antigens and antisera also differed significantly from previously described reference reagents. these findings demonstrate the necessity of using reference ma ... | 1975 | 811142 |
| assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli. | the fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed mycobacterium tuberculosis. phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas sodium aurothiomalate, hydroxychloroquine, and d-penicillamine had no effect. all the drugs used suppressed the infiltration of inflammatory cells into the cubes. | 1975 | 811180 |
| staphylococcal micrococcins. iii. antibacterial and therapeutic properties. | micrococcin m, micrococcin m1 and eight micrococcin m derivatives, and two peptide antibiotics produced by micrococci and staphylococci were investigated for their antibacterial activity and therapeutic value. these antibiotics appeared to act solely on gram-positive bacteria, especially on staphylococci and streptococci, in quite low concentrations in vitro and exerting both bacteriostatic and bactericidal effects. gram-negative bacteria were virtually not susceptible. resistance to micrococcin ... | 1975 | 811231 |
| enhancement of susceptibility to experimental phycomycosis by agents producing reticuloendothelial stimulation. | | 1975 | 811320 |
| effect of treatment with the mer fraction of tubercle bacilli on hydrolytic lysosomal enzyme activity of mouse peritoneal macrophages. | | 1975 | 811360 |
| molecular weight and other characteristics of mycobacterial growth inhibitory factor produced by spleen cells obtained from mice immunized with viable attenuated mycobacterial cells. | exposure of mycobacterial growth inhibitory factor (mycoif) to trypsin, chymotrypsin, or neuraminidase decrease its ability to produce intracellular inhibition of mycobacterial growth within macrophages, suggesting that mycoif was a glycoprotein. mycoif was unaffected by deoxyribonuclease or ribonuclease. supernatant fluids from antigenically stimulated h37ra-immunized mouse spleen cells exposed to puromycin were unable to produce significant intracellular inhibition. this indicated that the pre ... | 1975 | 811560 |
| macrophage migration inhibitory activity of mycobacterial growth inhibitory factor and the effect of a number of factors on mycobacterial growth inhibitory factor activity. | mycobacterial growth inhibitory factor (mycoif), which inhibits the intracellular multiplication of virulent tubercle bacilli within normal peritoneal macrophages in vitro, was tested for its ability to inhibit the migration of normal peritoneal exudate cells. the migration of peritoneal exudate cells was not inhibited by mycoif. it was also shown that normal peritoneal macrophages infected with virulent mycobacterium tuberculosis, strain h37rv, required 72 h of incubation with spleen cell cultu ... | 1975 | 811561 |
| comparison of four culture media for the isolation of mycobacterium tuberculosis: a 2-year study. | four media, lowenstein-jensen, middlebrook, petragnani, and ribonucleic acid, were tested for comparative ability to detect mycobacterium tuberculosis. specimens used included sputum, urine, tissue, and gastric washings. three types of comparison were used: (i) comparison derived from randomized specimens; (ii) comparison of cultures from newly diagnosed cases that had received no prior therapy; and (iii) comparison of cultures from specimens whose initial direct smears were negative. overall, r ... | 1975 | 811686 |
| radiometric detection of the metabolic activity of mycobacterium tuberculosis. | a radiometric test capable of detecting the metabolic rate of m. tuberculosis within 18 hr after inoculation has been developed. the technique is based on the measurement of 14co2 produced by the bacterial metabolism of 14c-u-glycerol of 14c-u-acetate. the test is an important first step in the development of rapid radiometric techniques for clinical study of mycobacterium tuberculosis. | 1975 | 811771 |
| tuberculosis in a community hospital. a five-year review. | between january 1969 and december 1973, at a community hospital in chicago, 129 patients had cultures positive for mycobacterium tuberculosis. on admission to the hospital, only 36% of the patients were suspected of having tuberculosis, even after the initial chest x-ray film was available. ten patients, in whom a positive culture was reported, were still living and had not been treated for tuberculosis as of june 1974. five of these patients probably never had the disease, and the other five pa ... | 1976 | 811821 |
| [epithelioid cell granuloma, its experimental production and induction mechanism (author's transl)]. | | 1975 | 811831 |
| adjuvant activity of mycobacterial fractions. iii. adjuvant effect of cell wall of mycobacterium bovis bcg on cell-mediated cytotoxicity in mice. | a quantitative assay and characterization of oil-attached cell wall of mycobacterium bovis bcg (bcg-cws) which stimulates cell-mediated immunity of spleen cells to alloantigens in mice were carried out by an in vitro cell-mediated cytotoxicity test using 51cr-labeled target cells. c57bl/6j mice (h-2b) were immunized intraperitoneally with mastocytoma cells (h-2d) with or without oil-attached bcg-cws. the cytotoxicity, comparable to that of spleen cells from mice immunized with mastocytoma cells ... | 1975 | 811834 |
| [experimental studies on the anti-tuberculous effect of bb-k8 (author's transl)]. | | 1975 | 811917 |
| [characteristic properties of culture media used in the sensitivity testing of mycobacteria]. | | 1975 | 811961 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 5-1976. | | 1976 | 811990 |
| evidence for infection by two distinct strains of mycobacterium tuberculosis in pulmonary tuberculosis: report of 9 cases. | the sputum cultures of 26 patients in whom bacteriologic relapse occurred during or after an initial course of treatment with antimicrobial drugs were compared by phage typing with cultures isolated previously from the same patients. nine (34 per cent) were different in phage type. whether this indicates exogenous reinfection as the mechanism for the relapse, the presence of two distinct phage types present from the outset, or change in phage type of the original single strain has not been deter ... | 1975 | 812397 |
| lifelong follow-up of inactive tuberculosis: its value and limitations. | there are 14,552 inactive cases of tuberculosis in british columbia, representing 0.6 per cent of the population. the prevalence of inactive tuberculosis in 7 times higher among indians than in the remainder of the population. among all inactive cases, 60.5 per cent of patients had "good" chemotherapy, whereas 13.2 per cent had poor chemotherapy and 26.3 per cent had no chemotherapy. the risk of reactivation in those who received "good" chemotherapy was 2.2 cases per 1,000 persons per annum, whe ... | 1975 | 812398 |
| laboratory services for mycobacterial diseases. | the philosophy of the recently proposed "levels of laboratory service" program, which will be so vital to the conduct of a successful outpatient tuberculosis treatment and control program, is presented. the hallmark of this program is the decentralization of the diagnostic/monitoring services as they involve laboratory participation. in the long run this could mean more efficient operation, more reliable reporting, and probably less work for the participating laboratories. the greater emphasis o ... | 1975 | 812399 |
| the growth of some mycobacteria on cultured human tissues. | m. ulcerans grows in close association with the surface of cultured human foetal and adult tissue and produces necrosis. m. tuberculosis grows also but m. xenopi grows little or not at all. the two first named seem to stick well to the tissue surface and the last does not. these results are discussed in relationship to the pathogenesis of buruli ulcer. | 1975 | 812545 |
| host-parasite interactions with peritoneal macrophages of mice and rats in vitro and in vivo. | this paper deals with the intracellular multiplication of mycobacteria in peritoneal macrophages from mice and rats immunized with tubercle bacilli or pretreated with triton wr 1339. if unstimulated macrophages were used, almost unrestricted multiplication of mycobacteria was observed in macrophages from both vaccinated and pretreated hosts after infection of the cells in vitro. only when the infection of the cells was perfored in the peritoneal cavity of vaccinated hosts did the macrophages dis ... | 1975 | 812825 |
| problems of allergenic and immunogenic mycobacterial antigens. | | 1975 | 812903 |
| influence of bcg vaccination on the pathogenesis of experimental airborne tuberculosis. | | 1975 | 812904 |
| nicotinic acid production of bcg substrains in relationship to their residual virulence and immunogenic efficacy. | | 1975 | 812905 |
| catalase electrophoretic mobility of some bcg substrains. | | 1975 | 812907 |
| studies on tuberculin-active peptides. | | 1975 | 812908 |
| results of the study of the w 115 m. tuberculosis vaccine strain and the lyophilized experimental vaccine w 115. | | 1975 | 812909 |
| the immunising efficiency of the avirulent strain m. tuberculosis weiszfeiler no. 115/9. | | 1975 | 812910 |
| the ultrastructure of lung tissue of rabbits infected intravenously with mycobacterium tuberculosis "weiszfeiler 115". | | 1975 | 812911 |
| antigen study of mycobacteria tuberculosis and bcg for detection of postvaccinal and infectious allergy. | | 1975 | 812912 |
| emergence of rifampin-resistant mycobacterium tuberculosis in massachusetts. | tests of sensitivity to rifampin of over 2,200 strains of mycobacterium tuberculosis demonstrated a progressive increase in the number of rifampin-resistant isolates during the past four years in massachusetts. no resistant strains were isolated in 1971, but two strains resistant to 1 mug of rifampin/ml were isolated in 1972. nine rifampin-resistant strains were isolated in 1973 and 16 were isolated in 1974. all but two of the resistant strains were isolated from patients who had received therap ... | 1976 | 812925 |
| host-parasite relationships in experimental airborne tuberculosis. v. lack of hematogenous dissemination of mycobacterium tuberculosis to the lungs in animals vaccinated with bacille calmette-guérin. | the influence of bacille calmette-guérin (bcg) on the pathogenesis of experimental airborne tuberculosis was studied. in a model that approximates the conditions under which man is vaccinated and infected, bcg-vaccinated and unvaccinated guinea pigs were infected by the respiratory route with an inoculum that resulted in the inhalation and retention (by each animal) of approximately three virulent tubercle bacilli (mycobacterium tuberculosis strain h37rv). hematogenous seeding of the lungs occur ... | 1976 | 812927 |
| evidence for host-dependent modification and restriction of bacteriophage dna in mycobacterium tuberculosis. | wild isolates of mycobacterium tuberculosis may be divided into the three internationally recognized phage types on the basis of susceptibility to mycobacteriophages ds6a, bk1 and d34. strains of type a are lysed at high efficiency by ds6a only; type b is lysed by bk1 grown on mycobacterium smegmatis atcc607 and ds6a, while type c is lysed additionally by d34 grown on atypical mycobacterium f130. propagation of d34 on a c-strain (d34-c) or bk1 on a b-strain (bk1-b) has no effect on viral host-ra ... | 1976 | 812956 |
| a study of the cerebrospinal fluid in atypical presentations of tuberculous meningitis. | atypical clinical and csf profiles encountered in tbm are highlighted. acid-fast bacilli (afb) were isolated from the csf of 7 patients in spite of the complete absence of any cellular response and also from another 3 patients who had no clinical evidence of meningitis. m. flavescens was cultured from the csf in 4 patients. | 1975 | 812961 |