| letter: malaria vaccines. | | 1975 | 805622 |
| effect of t-cell depletion on the growth of bcg in the mouse footpad. | the growth of mycobacterium bovis (bcg montreal) and m. tuberculosis erdman was determined in normal and t-cell depleted (thxb) mice when injected subcutaneously into a hind footpad. the bacilli multiplied only to a limited extent within the footpad itself but the infection quickly spread to the draining popliteal lymph node to eventually reach the liver, spleen and lung. the amount of systemic growth seen in the thxb mice was 10-100 times greater than in the normal controls, all of which develo ... | 1975 | 805768 |
| comparison of lymphocyte stimulation and tuberculin skin reactivity in mycobacterium bovis-infected macaca mulatta. | lymphocyte immunostimulation tests were conducted on mycobacterium bovis-infected and tuberculin-negative rhesus macaques (macaca mulatta), using purified protein derivative (ppd) tuberculins prepared from strains of mycobacterium tuberculosis and mycobacterium avium. the stimulation of lymphocytes with m tuberculosis ppd was significantly greater for the m bovis-infected macaques than for the noninfected controls (p smaller than 0.05). the response of lymphocytes from m bovis-infected macaques ... | 1975 | 806239 |
| transfer of adoptive immunity to tuberculosis in mice. | a system is described for studying adoptive immunity to tuberculosis in syngeneic mice. donor mice were immunized with 10(4) bcg intravenously, and lymphoid cells were harvested 28 days later. adoptive immunity was measured in recipient mice in terms of the inhibition of growth of bcg in the liver and spleen following intravenous injection. adoptive immunity was expressed optimally when recipients were sublethally irradiated (500 r), challenged with 10(4) to 10(5) viable organisms, and given sen ... | 1975 | 806520 |
| activation of mouse peritoneal cells to kill listeria monocytogenes by t-lymphocyte products. | an in vitro system has been used to demonstrate that glass-adherent mouse peritoneal cells can be activated to kill intracellular listeria monocytogenes by antigen-stimulated t-lymphocytes derived from immunized mice. the soluble products of such stimulated lymphocyte cultures could only be shown to similarly activate peritoneal cells if the antigen used in both the immunization and lymphocyte stimulation was also present on the target intracellular organism. | 1975 | 806534 |
| killing in vitro of trypanosoma cruzi by macrophages from mice immunized with t. cruzi or bcg, and absence of cross-immunity on challege in vivo. | peritoneal macrophages from t. cruzi-immune mice were resistant to infection in vitro with culture forms of the parasite. macrophage resistance appeared in infected mice about 21 days postinfection when parasitemia was still rising. resistance in vitro was nonspecific since macrophages from bcg-immune mice were resistant to t. cruzi, and since macrophages from t. cruzi-immune mice were resistant to infection in vitro with listeria were not resistant to challenge with t. cruzi even when the par ... | 1975 | 806649 |
| [anonymous acid-fast bacilli]. | | 1975 | 806990 |
| inactivation of phages ds6a and d29 by acetone extracts of mycobacterium tuberculosis and mycobacterium bovis. | the adsorption rate constant for mycobacteriophage ds6a on clumped cells of mycobacterium tuberculosis strain h37rv was found to be 6.33 x 10(-13) ml per min per colony former. acetone-extracted cells of h37rv did not absorb phage ds6a. acetone extracts of cells of h37rv and of mycobacterium bovis strain bcg inhibited plaque formation of mycobacteriophage ds6a and of phage d29. suspensions of these extracts in heart infusion broth with 0.002 m calcium chloride and 1 per cent dioxane required 20 ... | 1975 | 807139 |
| adjuvant activity of mycobacterial fractions. i. purification and in vivo adjuvant activity of cell wall skeletons of mycobacterium bovis bcg, nocardia asteroides 131 and corynebacterium diphtheriae pw8. | the adjuvant activity of cell wall skeletons (mycolic acid-arabino-galactan-mucopeptide, cws) prepared from the cells of mycobacteria, nocardia and corynebacteria was examined in vivo in mice and guinea pigs. the cell wall skeletons of mycobacterium bovis bcg (bcg-cws), nocardia asteroides 131 and corynebacterium diphtheriae pwc suspended in freund's incomplete adjuvant (fia) as water-in-oil emulsions showed potent adjuvant activity on the formation of circulating antibody and cell-mediated immu ... | 1975 | 807194 |
| [bcg potentiates the immunodepression induced by cyclophosphamide]. | compared to the effect of cpm alone, the survival of allogeneic c3h skin grafts on fl (dba/2 x c57bl/6) recipients is considerably enhanced when the recipient is given bcg (1 mg/mouse) 14 days before the graft and cpm (80 or 134 mg/kg) one day after the graft. while other mechanisms cannot be entirely excluded, it is possible that bcg stimulates the lymphocytes to enter the cell cycle, which makes them more sensitive to cpm, a cycle-dependent agent. | 1975 | 807370 |
| [comparative dose-effect relationship of a tuberculin standard on guinea pig sensitivity, using living and dead tuberculosis bacilli]. | the sensitization of guinea pigs utilized for tuberculin titration may be obtained by a bcg primo-vaccination followed by an inoculation of live, virulent myc. tuberculosis. this method, which results in a sub-evolutive form of tuberculosis, gives a satisfactory sensitization level but has the disadvantage of utilizing animals which are germ carriers and therefore dangerous. a method has been tested employing killed germs (jamaica strain) coated with freund's complete adjuvant h37ra which utiliz ... | 1975 | 807493 |
| infection of microtus arvalis (common vole) with mycobacterium tuberculosis and mycobacterium bovis. | the aim of the study has been to ascertain whether microtus arvalis (common vole) is strongly susceptible to m. bovis but resistant to m. tuberculosis, as is the case with other members of the vole family, or whether it is susceptible to both species as demonstrated by robert koch. groups of common voles have been injected subcutaneously or intraperitoneally with varying doses of finely dispersed suspensions of a virulent strain of m. bovis or m. tuberculosis. m. bovis multiplies strongly in the ... | 1975 | 808093 |
| bacteraemia in red mice (clethrionomys g. glareolus schreb.) after intraperitoneal injection of large doses of tubercle bacilli. | römer (1903) has demonstrated that white mice injected intraperitoneally with large doses of tubercle bacilli isolated from man survived longer than mice injected with tubercle bacilli isolated from cattle. the blood of the spontaneously dead animals contained large numbers of tubercle bacilli. in the present study, red mice are injected intraperitoneally with 10 mg doses of different species of mycobacteria, and the number of bacilli in the blood is estimated at various intervals within the fir ... | 1975 | 808094 |
| [the influence of sodium pyruvate on the isolation sensitivity and on contamination of the löwenstein-jensen media (author's transl)]. | | 1975 | 808255 |
| chemical studies on tuberactinomycin. viii. isolation of tuberactinamine n, the cyclic peptide moiety of tuberactinomycin n, and conversion of tuberactinomycin n to o. | tuberactinamine n, the cyclic peptide moiety of tuberactinomycin n, was obtained in a crystalline state through liberation of gamma-hydroxy-beta-lysine from tuberactinomycin n by acid treatment. tuberactinamine n possesses an intramolecular hydrogen bond in its molecule and showed antibacterial activities comparable to those of the original antibiotics. conversion of tuberactinomycin n to o was achieved through coupling of diacyl-beta-lysine with tuberactinamine n followed by removal of the pr ... | 1975 | 808523 |
| bcg immunopotentiation of an antitumor response: evidence for a cell-mediated mechanism. | bcg-immunopotentiated antitumor immunity was studied in a model in which irradiated murine tumor cells, mastocytoma p815, were injected into subcutaneous sites prepared by a prior injection of bcg; challenge in a distant foot-pad was used as an indicator of specific resistance. the onset of antitumor immunity correlated with the proliferation of lymph node cells draining the immunization sites and the development of delayed type hypersensitivity (dth) to the tumor. tuberculin hypersensitivity, h ... | 1975 | 808641 |
| the species distribution of three concanavalin a-purified mycobacterial polysaccharides. | culture filtrates prepared from 12 species of mycobacteria were examined for the presence of 3 mycobacterial polysaccharides previously purified by concanavalin a affinity chromatography. four commercial old tuberculins, tuberculin tine test units, and purified protein derivative were also studied. all 3 polysaccharides were demonstrated in all of the filtrates and each of the old tuberculins and purified protein derivative. the amount of concanavalin a-nonreactive polysaccharide was measured in ... | 1975 | 808990 |
| the indirect fluorescent antibody test for the detection of circulating antibodies in bovine tuberculosis. | indirect fluorescent antibody (ifa) tests were carried out on a total of 545 individual serums from beef cattle just before tuberculin testing, using specific fitc-anti-bovine igg and igm conjugates. phenol-killed m. tuberculosis (h37rv strain) or field strains of m. bovis and m. avium were used as antigenic substrates. all cattle were examined at abattoirs for the presence of tuberculous lesions. a statistically significant difference (p less than 0.001) was found between the number of cattle w ... | 1975 | 809031 |
| differentiation of known strains of bcg from isolates of mycobacterium bovis and mycobacterium tuberculosis by using mycobacteriophage 33d. | the use of mycobacteriophage 33d to differentiate strains of bcg from isolates of mycobacterium bovis was investigated. the procedure was found to be reproducible and, using the commercially available media described, can be recommended for use in mycobacterial reference laboratories. | 1975 | 809476 |
| resistance of trypanosoma cruzi to killing by macrophages. | | 1975 | 809716 |
| [characteristics of mycobacteria isolated from diagnostic obtained from tuberculous patients in selected environments]. | | 1975 | 810393 |
| [immune manipulation of bcg administered before or after cyclophosphamide for chemo-immunotherapy of l1210 leukemia]. | 1. bcg (1 mg/mouse) administered i.v. on day 5 after chemotherapy by cyclophosphamide (cpm), given itself at the dose of 80 or 134 or 403 mg/kg one day after the inoculation of l 1210 leukaemia 10(3) cells, increases the effect of the non-optimal doses: i.e. 80 mg/kg, which is insufficient to cure mice, and 403 mg/kg, which is toxic. it does not change the effect of the optimal dose of cpm (134 mg/kg) which cures most of the mice. 2. bcg (1 mg/mouse i.v.) given on day 15 before cpm decreases the ... | 1975 | 811377 |
| adjuvant activity of mycobacterial fractions. iii. adjuvant effect of cell wall of mycobacterium bovis bcg on cell-mediated cytotoxicity in mice. | a quantitative assay and characterization of oil-attached cell wall of mycobacterium bovis bcg (bcg-cws) which stimulates cell-mediated immunity of spleen cells to alloantigens in mice were carried out by an in vitro cell-mediated cytotoxicity test using 51cr-labeled target cells. c57bl/6j mice (h-2b) were immunized intraperitoneally with mastocytoma cells (h-2d) with or without oil-attached bcg-cws. the cytotoxicity, comparable to that of spleen cells from mice immunized with mastocytoma cells ... | 1975 | 811834 |
| nicotinic acid production of bcg substrains in relationship to their residual virulence and immunogenic efficacy. | | 1975 | 812905 |
| the immunological methods of enzyme estimation in m. bovis bcg homogenates. the estimation of peroxidase by the methods of immunodiffusion and immunoelectrophoresis. | | 1975 | 812906 |
| catalase electrophoretic mobility of some bcg substrains. | | 1975 | 812907 |
| results of the study of the w 115 m. tuberculosis vaccine strain and the lyophilized experimental vaccine w 115. | | 1975 | 812909 |
| the immunising efficiency of the avirulent strain m. tuberculosis weiszfeiler no. 115/9. | | 1975 | 812910 |
| antigen study of mycobacteria tuberculosis and bcg for detection of postvaccinal and infectious allergy. | | 1975 | 812912 |
| the genetics of mycobacteria and mycobacteriophages - a review. | the genus mycobacterium, despite its medical importance, has so far received relatively little attention from bacterial geneticists. nevertheless examples of the transfer of genes from one strain to another by means of transformation, phage-mediated transduction and direct cellular contact have been reported. the modification of strains by experimental or naturally occurring lysogeny has been studied in some detail and there is evidence that phage may contribute significantly to variation within ... | 1975 | 814665 |
| multiplication of mycobacterium tuberculosis and mycobacterium bovis in microtus agrestis (field vole). | the multiplication of bacteria is examined by quantitative culture from the organs of two groups of field voles injected intraperitoneally with a large dose of m. tuberculosis or a small dose of m. bovis and killed at intervals during a period of up to 3 months after the injection. m. tuberculosis given in a dose of 7 x 10(5) viable units did not multiply, or multiplied only to a small extent. none of the animals in the group died from tuberculosis and the macroscopical lesions found at autopsy ... | 1976 | 814785 |
| gas chromatographic characterization of mycobacteria: analysis of fatty acids and trifluoroacetylated whole-cell methanolysates. | mycobacterium avium, m. bovis strain bacillus calmette-guerin (bcg), m. kansasii, and m. tuberculosis were studied by gas-liquid chromatography. methylated fatty acids of the mycobacterial lipids and trifluoroacetyl (tfa) derivatives of whole-cell methanolysates were analyzed. both the fatty acid and the tfa chromatograms showed reproducible differences between the various mycobacteria studied. chromatograms from different strains of one and the same species showed negligible differences. fatty ... | 1976 | 815272 |
| practical application of bovine tuberculin ppd in testing cattle in great britain. | a national tuberculin testing trial was carried out in 8151 cattle in 132 herds due for normal herd testing and distributed throughout the 11 animal health administrative regions of england, scotland and wales. the numbers selected from each region were in approximately equal proportions to the total cattle populations of the regions and comprised a representative sample of the national herd. the standard intradermal comparative tuberculin test using weybridge avian and human purified protein de ... | 1976 | 816049 |
| [the effect of an inflammatory reaction induced either by bcg or a non-biodegradable irritant on the resistance to bilharziasis in mice]. | | 1976 | 816529 |
| separation of an adjuvant-active glycolipid lacking peptide moiety from wax d preparation of mycobacterium tuberculosis strain aoyama b. | | 1976 | 816734 |
| immune response of guinea pigs with deal's sarcoma to different strains of mycobacteria. | | 1976 | 816967 |
| a comparison of several intradermal tuberculins in macaca mulatta during an epizootic of tuberculosis. | during an epizootic of tuberculosis in rhesus monkeys, several intradermal test reagents were compared for accuracy in detecting tuberculosis and for strength of reaction elicited. a purified protein derivative of mycobacterium bovis, similar to one which will probably be approved for official veterinary testing and thus eliminate tuberculin-mammalian intradermic from commercial production, was among those evaluated. none of the reagents was found to be superior to tuberculin-mammalian intraderm ... | 1976 | 817080 |
| ultraviolet susceptibility of bcg and virulent tubercle bacilli. | to test the effectiveness of irradiating the upper air of a room with ultraviolet light at reducing the concentration of airborne tubercle bacilli, the susceptibility to the germicidal effects of ultraviolet light, z, was determined for various mycobacteria. virulent tubercle bacilli and bacille calmette-guérin (bcg) were equally susceptible to ultraviolet radiation, whereas mycobacterium phlei had 10 times their resistance (z, approximately one-tenth that for m. tuberculosis). the effectiveness ... | 1976 | 817628 |
| effect of cell-wall skeleton of mycobacterium bovis bcg on cell-mediated cytotoxicity in tumor-bearing mice. | effect of oil-attached bcg cell-wall skeleton (bcg-cws) on cell-mediated cytotoxicity in tumor-being mice was investigated using the allograft system. it was found that the treatment with oil-attached bcg-cws was able to elevate the immunolgically depressed state of tumor-bearing mice to a normal level as determined by chromium release assay. | 1975 | 817955 |
| analysis of the cell wall of five strains of myocbacterium tuberculosis bcg and of an attenuated human strain, w 115. | the chemical composition of the deproteinized, delipidated cell walls of five strains of bcg and of an attenuated human strain of mycobacterium tuberculosis has been established, with special focus on their poly-l-glutamic acid content. all the cell walls have the same overall composition. their poly-l-glutamic acid content varies from 0 to 4.6%. a correlation between the poly-l-glutamic acid content and the biological properties of the bcg strains reported in the literature could not be establi ... | 1976 | 818013 |
| enhancement activity of anti-mycobacterial sera in experimental mycobacterium bovis (bcg) infection in mice. | the passive transfer of rabbit anti-mycobacterial immunoglobulins was directed against either living or soluble extracts of mycobacterium tuberculosis strain h37rv, which promotes the multiplication of the bcg strain of m. tuberculosis in the spleen of mice infected with low doses of this latter strain. this enhancing effect was reduced significantly when antisera were absorbed with living bcg. moreover, such treatment led to the removal of all hemagglutinating antibodies when antisera were test ... | 1976 | 818022 |
| results of long-term preservation of mycobacteria by means of freeze-drying. | | 1976 | 819214 |
| [immunity against mycobacterium, with special reference to the experiments using bcg cell wall]. | | 1976 | 819704 |
| [response to ppd in tuberculosis patients infected with m tuberculosis and m bovis]. | | 1976 | 819758 |
| investigation of the inhibitory activity of some mycobacterial strains on growth of the intratracheally transplanted deals' sarcoma in guinea pigs. | in this paper the authors describe and analyse results that they obtained by infection of the guinea pig organism carried out by subcutaneous or intratracheal application with five mycobacterial strains, namely myco bovis bcg-praha, myco the h37ra, myco kansasii, myco fortuitum and myco smegmatis. at predetermined time intervals following subcutaneously or intratracheally performed infection (on 7th, 16th, 28th and 56th day after infection) transplantation of a deals' guinea pig sarcoma cell sus ... | 1976 | 819851 |
| [bovine tuberculosis, isolation of mycobacteria from cattle]. | | 1976 | 820000 |
| adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic n-acetylmuramyl-dipeptide and the related compounds. | immunological activity of synthetic cell wall peptidoglycan subunits was examined in guinea pigs and mice. it was concluded that the minimal adjuvant-active subunit of cell wall peptidoglycan for the induction of delayed-type hypersensitivity to monoazobenzenearsonate-n-acetyl-l-tyrosine and for circulating-antibody formation to bacterial alpha-amylase and the thymus-independent antigen dnp-ficoll was n-acetylmuramyldipeptide, murnac-l-ala-d-isogln. n-acetylmuramyldipeptide and 6-o-stearoyl-n-ac ... | 1976 | 820642 |
| methanol extraction residue fraction of tubercle bacilli (mer) and other mycobacterial extracts as systemic immunity adjuvants in cancer immunotherapy. | four mycobacterial extracts--two water soluble and two water insoluble--were tested for their immunostimulatory and antitumor activities: mer, the methanol extraction residue fraction of tubercle bacilli (insoluble); hiu i, an insoluble component of the membrane of whole cells of bacillus calmette-guérin (bcg); hiu ii, a soluble component of bcg; and lederer's wsa, a soluble extract of mycobacterium smegmatis. in a hemolytic plaque-forming cell assay, mer, hiu ii and wsa showed immunostimulator ... | 1976 | 820673 |
| intracavitary bacillus calmette-guerin in the treatment of superficial bladder tumors. | patients with recurrent superficial bladder tumors have been treated by vesical and intradermal administration of bacillus calmette-guerin. the pattern of recurrence in 9 patients has been altered favorably. although the findings are still preliminary they appear to hold promise of a new therapeutic approach to the treatment of a group of neoplasms for which effective therapy is still lacking. | 1976 | 820877 |
| [immunological properties of attenuated tuberculosis strain "bk-kharkov". i. the comparative characteristics of the structural lipids and their relationship to the immunogenic properties of the "bk-kharkov" and bcg strains]. | | 1976 | 820948 |
| [use of immunologic methods for the detection of dehydrogenases of bcg substrains]. | | 1976 | 821044 |
| stimulation of the non-specific resistance by corynebacterium parvum and bacillus calmette guérin. | the effect of pretreatment of intravenously administered killed corynebacterium parvum (cp) and living bcg was studied in various model systems. both vaccines caused an increased resistance to listeria monocytogenes, indicating macrophage activation. only cp exerted a suppressive effect on t-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult t. spiralis worms from intestine). results of experiments with congenitally athymic ( ... | 1976 | 821172 |
| comparison of mycobacterium africanum, m. tuberculosis and m. bovis by their utilization of carbon and nitrogen sources. | | 1975 | 821405 |
| [preferential differentiation of hematopoietic stem cells in mice after intravenous injection of bcg]. | following the intravenous injection of 1 mg of bcg into mice an anemia with erythroblastopenia is observed in spite of a high level of erythropoietin. a preferential differentiation of hematopoietic stem cells to leucocytes is observed with a concomitant of the differentiation to erythrocytes. | 1976 | 821656 |
| the application of hückel molecular orbital calculations to study of antituberculotic activity of thioamides. | | 1976 | 821773 |
| a new practical classification of the mycobacteria. | a new classification is presented for mycobacteria cultured from clinical specimens. five categories were defined on temperature requirement, and these were subdivided into 14 groups by pigmentation, oxygen preference and tween hydrolysis. support for some of the groups and for the recognition of certain important species within others was provided by drug-sensitivity tests. less than 1-0% of the opportunist mycobacteria met in britain eluded classification by these means. | 1976 | 822166 |
| partial characterization of a factor extracted from sensitized lymphocytes that inhibits the growth of mycobacterium tuberculosis within macrophages in vitro. | spleen lymphocytes of bcg-immunized mice contain a soluble factor that inhibits in vitro the growth of the h37rv strain of mycobacterium tuberculosis within normal peritoneal macrophages. the water-soluble extracts of sensitized lymphocytes, disrupted by freezing and thawing, although less active than the corresponding viable cells retained a significant growth-inhibiting activity. dialysis against distilled water, lyophilization, exposure to ribonuclease and deoxyribonuclease, and storage at -2 ... | 1976 | 823109 |
| [sensitivity tests of mycobacteria to inh, sm, emb and rmp in a semi-liquid serum-sauton-agar (author's transl)]. | in this article a simple method of sensitivity testing of mycobacteria in semi-liquid serum-sauton-agar as ahsk-test is described and first results are reported. the sensitivity to inh, sm, emb and rmp is tested. in comparative tests between the economical-test and the ahsk-test a total of 100 strains of mycobacteria of different sensitivity are investigated. the results largely agree with each other, from which the evaluation of the sensitivity test in the ahsk-test in 54% of the strains after ... | 1976 | 823718 |
| tuberculin shock in red mice and cf1 mice immunized with strains of bcg or mycobacterium tuberculosis. | groups of red mice and cf1 mice immunized intravenously with varying doses of a weak and a strong strain of bcg and a strain of m. tuberculosis were challenged 3-4 weeks later with 2 or 0.5 mg of purified tuberculin injected intravenously. the shock sensitivity of the animals in the individual groups was evaluated on the basis of the number of deaths and the survival times after challenge. in the red mice, the strain of m. tuberculosis induced a significantly greater sensitivity than the bcg str ... | 1976 | 823795 |
| activation of guinea pig macrophages by cell walls of mycobacterium bovis, strain bcg. | | 1976 | 824056 |
| an attempt to cultivate mycobacteria in simple synthetic liquid medium containing lecithin-cholesterol liposomes. | an attempt was made to cultivate mycobacteria in a simple synthetic liquid medium containing lecithin-cholesterol liposomes. this lipid complex showed a marked growth-promoting effect on the submerged growth of m. tuberculosis and m. bovis. the role of lecithin as nutrient was suggested. the bacillary growth in such environment retained good viability, strong acid-fastness, and high virulence in mice. an avirulent strain of tubercle bacilli, h37ra, did not respond to lecithin-cholesterol liposom ... | 1976 | 824481 |
| accumulation of cholesterol esters in macrophages incubated with mycobacteria in vitro. | macrophages separated from the granulomatous lungs of tuberculous mice had a high amount of cholesterol esters. resident peritoneal macrophages of normal mice were very low in the ester content. however, when the cells were incubated with mycobacteria in hanks' solution the ester content of the mixture increased greatly. peritoneal macrophages harvested by induction with casein had a much larger amount of cholesterol esters than unstimulated resident cells. when such stimulated macrophages were ... | 1976 | 824482 |
| mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms. | the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ... | 1976 | 824484 |
| [presence and significance of mycobacteria in animals (proceedings)]. | | 1976 | 824890 |
| [immunization by canadida albicans and non-specific immunostimulation by corynebacterium granulosum and bcg in experimental candidiasis]. | immunostimulation by corynebacterium granulosum (whole bacteria or a delipided fraction p40) or by live bcg enhanced the resistance of lethally infected mice by candida albicans. the protection is greater by association with an active specific immunization by various preparations of c. albicans. | 1976 | 825252 |
| immunotherapy of cancer with cell wall skeleton of myocabacterium bovis-bacillus calmette-guérin: experimental and clinical results. | adjuvant and antitumor activities of cws prepared from cells of mycobacteria, nocardia, and corynebacteria were examined. oil-attached cws of m. bovis bcg (bcg-cws) stimulated the generation of cell-mediated cytotoxic effector cells in mice. tumor growth was suppressed in mice inoculated intradermally with a mixture of oil-attached cws and living tumor cells. systemic and specific tumor immunity was demonstrated in mice in which tumor growth was suppressed. tumor growth was also suppressed by oi ... | 1976 | 826205 |
| granulomagenic activity of serologically active glycolipids from mycobacterium bovis bcg. | the granulomagenic properties of serologically active glycolipids a1, b2, b3, and c isolated from mycobacterium bovis bcg were studied. glycolipid a1, dissolved in olive and injected intradermally in guinea pigs, was able to elicit a granulomatous response that seemed to be of the nonallergic type. this granulomagenic activity was quite striking since only 2 mug was necessary to elicit the reaction. the b and c glycolipids were milder granulomagenic agents. glycolipid a1, dissolved in olive oil ... | 1976 | 826485 |
| a suggested role of a host-parasite lipid complex in mycobacterial infection. | on the basis of our previous observations and related literatures, was assumed tht cholesterol esters of host origin and phthiocerol dimycocerosate of bacterial origin are located as a lipid mixture around the periphery of pathogenic mycobacteria growing in vivo, probably within the phagocytic vacuole of macrophages. to examine the role of such a postulated lipid complex in mycobacterial infection, a model experiment was made in which tubercle bacilli grown in vitro were "coated" with both lipid ... | 1976 | 826675 |
| [bactericidal effect of rifampicin]. | | 1976 | 827746 |
| the balance of host immunocompetence in chemical carcinogenesis and "nonspecific" immunotherapy. | | 1975 | 827793 |
| studies on the intergenerical precipitinogen beta with special reference to its presence in mycobacterial ribosomes. | | 1976 | 828148 |
| adjuvant activity of 6-o-mycoloyl-n-acetylmuramuyl-l-alanyl-d-isoglutamine. | immunological properties of synthetic 6-o-mycoloyl-n-acetylmuramyl-l-alanyl-d-isoglutamine (6-o-mycoloyl-n-acetylmuramyldipeptide) and 6-o-mycoloyl-n-acetylmuramic acid were examined in guinea pigs and mice in comparison with those of bcg cell-wall skeleton, n-acetylmuramyl-l-alanyl-d-isoglutamine, and 6-o-stearoyl-n-acetylmuramyl-l-alanyl-d-isoglutamine. 6-o-mycoloyl-n-acetylmuramyldipeptide showed a potent adjuvant activity for the induction of delayed type hypersensitivy to n-acetyl-l-tyrosin ... | 1976 | 828599 |
| comparison of chemical and biological properties of water-soluble adjuvants prepared from mycobacterium tuberculosis, mycobacterium bovis and mycobacterium smegmatis. | | 1976 | 829910 |
| characterization of macrophage chemotaxins in tumor cell cultures and comparison with lymphocyte-derived chemotactic factors. | culture fluids from five murine sarcomas were chemotactic for syngeneic peritoneal macrophages in vitro. peritoneal macrophages from mice infected with mycobacterium bovis, strain bacillus calmette-guérin, were more responsive to the chemotactic factor in tumor cultures than were normal macrophages. peritoneal granulocytes, however, did not significantly respond to this factor. the level of chemotactic activity in tumor cultures paralleled cell growth for all five tumors; maximal levels occurred ... | 1977 | 837372 |
| mycobacterium bovis (bcg) infection of the lymph nodes of normal, immune, and cortisone-treated guinea pigs. | strain-2 inbred guinea pigs were infected intradermally with 10(5)-10(7) viable bcg (pasteur) organisms by means of multiple scarifications of shaven midflank skin. the spread of the bcg to the draining lymph nodes and on to the spleen was followed quantitatively for 28 days. the population of bacilli at the inoculation site increased as much as tenfold the first 14 days. the number of viable bcg organisms recovered from the primary draining superficial dorsal axillary and inguinal lymph nodes v ... | 1977 | 909109 |
| induction of antituberculous immunity by polysaccharidic contaminants of crude ribosomal vaccines isolated from mycobacterium bovis, strain bcg. | crude ribosomal fractions isolated from the bcg strain of mycobacterium bovis are capable of inducing antituberculous immunity in cf-1 mice. these crude preparations contain varying amounts of polysaccharides in addition to ribosomal ribonucleic acid and proteins. whereas these latter two constituents of the crude fractions were found inactive, high levels of antituberculous immunity were induced by a ribosomal sub-fraction significantly enriched with polysaccharides. these results strongly sugg ... | 1977 | 928854 |
| experimental cancer immunotherapy: comparison of tumor rejection if f344 rats given live mycobacterium bovis (strain bcg) and killed corynebacterium parvum. | f344 rats received grafts of syngeneic 13762 mammary adenocarcinoma cells previously admixed with either living bcg of killed corynebacterium parvum administered sc or intradermally (id). animals given id transplants of tumor cells admixed with either bcg or killed c. parvum exhibited tumor growth for an average of 10 days, then regression in size and rejection of the tumor nodules. lesions were found in rats given sc transplants of tumor cells admixed with the killed microorganism for an averag ... | 1976 | 994209 |
| relative immunogenicity of streptomycin-susceptible and -resistant strains of bcg. ii. effect of the route of inoculation on growth and immunogenicity. | normal cd-1 mice were infected intravenously, subcutaneously, or aerogenically with live bacille calmette guerin (bcg) tice or bcg streptomycin resistant (sm-res) and growth of the organisms in the footpad, the draining popliteal lymph node, the blood, lung, liver, and spleen was followed for as long as 50 days. the vaccinated mice were then challenged on day 50 with 10-5 viable mycobacterium tuberculosis erdman organisms introduced intravenously or subcutaneously. the growth of the erdman chall ... | 1975 | 1089372 |
| activation of lymphoid cells by bcg in vitro. | | 1975 | 1089480 |
| studies on the composition of adjuvants which selectively enhance delayed-type hypersensitivity to lipid conjugated protein antigens. | hen egg albumin (hea), heavily conjugated with dodecanoic acid (d-hea), stimulated sustained delayed type hypersensitivity (dth) specific for hea without detectable antibody formation in guinea pigs. an oil-in-water emulsion containing purified bcg cell walls attached to the oil drops was found to be a very effective adjuvant for enhancing dth to d-hea, but not to hea. animals immunized with d-hea in the bcg cell wall emulsion produced skin test reactions 2.4 cm in diameter when challenged with ... | 1975 | 1089714 |
| capillary density in developing and healing tuberculous lesions produced by bcg in rabbits. a quantitative study. | dermal tuberculous lesions were produced in rabbits by the intradermal injection of bcg. at various times after infection, anesthetized animals were perfused with a gelatin-colloidal carbon medium via the abdominal aorta. the capillary density of the nonnecrotic granulation tissue in the lesions was determined quantitatively by counting the capillaries under an ocular grid of a microscope. the capillary density in normal skin near the lesions was 3.8 plus or minus 0.5 in millimetersof capillary ... | 1975 | 1090183 |
| [immunologic methods of peroxidase detection in homogenates of bacilli of bcg substrains. ii. use of 2-dimensional immunoelectrophoresis for the immunologic demonstration of peroxidase]. | | 1975 | 1090486 |
| growth of mycobacterium bovis (bcg) in t lymphocyte-depleted mice. | bcg montreal (10-6 viable bacilli) injected intravenously into adult thymectomized, irradiated, and bone marrow-reconstituted (thxb) c57bl times c3h f1 hybrid mice induced a progressive systemic infection which killed 95% of the animals within 60 days. control mice infected with this dose of bcg did not die. the infected thxb mice failed to develop detectable levels of tuberculin hypersensitivity although they did show considerable arthus (3 h) reactivity. the bcg-infected thxb mice lost weight ... | 1975 | 1090526 |
| a stable form of delayed-type hypersensitivity. | an antigen dose below the level needed to provoke an antibody response produces in mice a persistent, but minor degree of delayed-type hypersensitivity (dth) to sheep red blood cells. the dth is unstable. it is erased by larger doses of antigen and cannot be built upon by further antigenic stimulation. the much higher levels of dth resulting from immunization under the modulating influence of cyclophosphamide (cy) or bcg persist under strong secondary antigenic stimulation, though the former is ... | 1975 | 1090700 |
| a rare and complex case of multifocal mucocutaneous lupus tuberculosis with isolated lesion of the tongue. | we have described a case of plurifocal tuberculous lupus with a localization limited to the tongue. this finding is remarkable because of its rarity. the weakly positive tuberculin reaction and the discovery of a concomitant myeloproliferative syndrome add interest and complexity to the case. | 1975 | 1090870 |
| evidence of cytotoxic t and b immunoblasts in the thoracic duct of rats bearing tumour grafts. | wistar rats were immunised with allogeneic or xenogeneic tumour before collection of their thoracic duct lymph. specifically cytotoxic effector cells were found in the lymph between 3 and 8 days after immunisation, and their occurrence coincided with an increased number of immunoblasts in the lymphocyte population. the immune response in lymph to allogeneic cells appeared to be affected solely by radiosensitive thymus-dependent lymphocytes; no complement-dependent killing was evident and cytotox ... | 1975 | 1091036 |
| the effects of bcg on the dog bladder. | immunostimulation with agents such as bacillus calmette-guérin (bcg) may represent an adjunctive treatment modality in patients with cancer of the bladder. to investigate the effects of direct inoculation, bcg was injected into the bladder of sensitized (ppd) and nonsensitized dogs. a marked and predictable inflammatory reaction was seen in all of the sensitized and in some of the nonsensitized dogs. this reaction was characterized by an extensive histiocytic infiltration with varying proportion ... | 1975 | 1091593 |
| specific and nonspecific antitumor immunity. ii. macrophage-mediated nonspecific effector activity induced by bcg and similar agents. | the recently described inhibition of dna synthesis (ids) assay, which measures antitumor effector (e) cell function by the quantitation of decreases in tritiated thymidine incorporation of target tumor cells, was used to analyze the nonspecific effector activity of peritoneal exudate cells (pec) from mice infected intraperitoneally with bcg. these pec could inhibit growth of and then kill all tumor target (effector to target) cells tested at e/t ratios as low as 1:1. this activity was not due to ... | 1975 | 1091741 |
| differential cytotoxicity of tumorigenic and nontumorigenic strain-2 guinea pig cells as mediated by syngeneic phytohemagglutinin-stimulated peritoneal exudate cells. | phytohemagglutinin (pha)-stimulated peritoneal exudate (pe) cells from strain-2 guinea pigs were more cytotoxic in culture to syngeneic tumorigenic cells than to syngeneic nontumorigenic cells. cytotoxicity was measured by the release of 3h-thymidine from prelabeled target cells. tumor-producing guinea pig fetal cells transformed in culture by chemical carcinogen released up to 70 percent of their label in the presence of pha-stimulated pe cells. non-tumor-producing cells, regardless of their mo ... | 1975 | 1091742 |
| mouse mononuclear cell chemotaxis: description of system. | the mononuclear cell chemotaxis assay was adapted for use with normal mouse peritoneal cells. mouse peritoneal macrophages responded well to endotoxinactivated mouse serum and to chemotactic factors produced by mouse spleen cell cultures stimulated with mitogens or specific antigen. the assay was quantitative, reproducible, and applicable to several mouse strains. | 1975 | 1091744 |
| [the activity of transaminating enzymes in mycobacteria of different virulence]. | | 1975 | 1092104 |
| development of specific in vitro lymphocyte responses in cattle infected with mycobacterium bovis and with mycobacterium avium. | two calves infected with mycobacterium avium and another 2 with mycobacterium bovis were studied for development and specificity of lymphocyte activation responses and skin reactivity to purified protein derivatives (ppd). lymphocytes cultured in vitro from infected calves manifested significant uptake of tritiated thymidine in response to the ppd prepared from the homologous organisms, whereas heterologous ppd produced little or no stimulation. the time of appearance of specifically sensitized ... | 1975 | 1092232 |
| the effect of p-aminosalicyclic acid on iron transport and assimilation in mycobacteria. | p-aminosalicylic acid inhibits growth of mycobacterium bovis bcg and mycobacterium smegmatis more effectively if cells are growing with a sufficiency of iron (more than 1 mu g fe/ml) in the medium than if cells are deficient in iron (smaller than 0.1 mu g fe/ml). in iron-deficient cultures formation of mycobactin, an ionophore for iron transport, is strongly inhibited by p-aminosalicylic acid. uptake of iron into cell suspensions is also inhibited and the activity of several iron-containing enzy ... | 1975 | 1092357 |
| increased chemotactic responses of macrophages from bcg-infected mice. | | 1975 | 1092474 |
| interaction of bcg-activated macrophages with neoplastic and nonneoplastic cell lines in vitro : quantitation of the cytotoxic reaction by release of tritiated thymidine from prelabeled target cells. | peritoneal cells from mice infected ip with mycobacterium bovis, strain bcg, were cytotoxic to syngeneic tumor cells in vitro. cytotoxicity was estimated by measurement of release of tritiated-thymidine (3-h-tdr) from prelabeled target cells. the cell responsible for tumor cytotoxicity was the macrophage. macrophages from uninfected mice or from oil-, starch-, or thioglycollate-induced peritoneal exudates had little effect on labeled tumor monolayers. tumoricidal macrophages were present at 3-7 ... | 1975 | 1092874 |
| [action mechanism of anti-tuberculosis drugs]. | | 1975 | 1092905 |
| immunotherapy with cultured human cells and bcg. | | 1975 | 1093299 |
| use of oral and intraperitoneal bcg in the treatment of malignant melanoma and adenocarcinoma. | | 1975 | 1093646 |
| immunotherapy of prostatic carcinoma with bacillus calmette-guerin. | seventeen patients with histologically proven adenocarcinoma of the prostate were selected for evaluation of their immunologic competence and therapy with bacillus calmette-guérin (bcg). all patients were in stage d. the immune response was explored in two main aspects: cell-mediated and humoral immunity. delayed skin hypersensitivity reaction with purified protein derivative (ppd), streptokinase-streptodornase (varidase), candida, mumps antigen, and trichophyton were tested. lymphocyte reactivi ... | 1975 | 1093665 |
| effects of methanol extraction residue and therapeutic irradiation against established isografts and simulated local recurrence of mammary carcinomas. | female balb/c mice carrying established isografts or simulated local recurrence implants of 2 rapidly growing mammary adenocarcinomas were treated either by injection of the methanol extraction residue (mer) fraction of killed bacillus calmette-guérin organisms (given s.c. or into the tumor) or by focal x-irradiation or by both. none of the modalities of therapy effected cures, but in many instances there was a significant retardation of tumor cevelopment and prolongation of the lives of the mic ... | 1975 | 1093676 |