| dexamethasone regulation of the expression of cytokine mrnas induced by interleukin-1 in the astrocytoma cell line u373mg. | bsf-2/il-6, gm-csf and il-1 beta mrnas were induced by recombinant il-1 in human astrocytoma cell line u373mg. the induction of bsf-2/il-6 and il-1 beta mrnas did not require de novo protein synthesis while that of gm-csf mrna required a newly synthesized protein. dexamethasone inhibited the induction of these cytokine mrnas by il-1. this process seems to require continued protein synthesis. these results suggest that the production of these cytokines are positively and negatively controlled by ... | 1989 | 2646146 |
| study of cell kinetics in anaplastic thyroid carcinoma transplanted to nude mice. | the cell kinetics of the transplantable human anaplastic thyroid carcinoma were studied in athymic nude mice using bromodeoxyuridine (brdu) pulse labeling. in order to estimate the cell cycle time in this study, the percent labeled mitosis curve was prepared with immunoperoxidase staining using monoclonal antibody to brdu instead of 3[h]thymidine autoradiography. this technique was considered to be very useful because it can be done for a short term and can still be changed to the autoradiograph ... | 1989 | 2654483 |
| in vitro antibacterial activity of sm-7338, a carbapenem antibiotic with stability to dehydropeptidase i. | sm-7338, a new carbapenem antibiotic, was demonstrated to have potent antibacterial activity against a broad spectrum of aerobes, including staphylococcus aureus, beta-hemolytic streptococci, streptococcus pneumoniae, haemophilus influenzae, neisseria spp., members of the family enterobacteriaceae, pseudomonas spp., and gram-positive and gram-negative anaerobes in a collection of 1,102 unselected clinical isolates. at a concentration of 0.5 micrograms/ml, sm-7338 inhibited 90% of these strains. ... | 1989 | 2655530 |
| a role for hemispheric asymmetry in human behavioral variability. | a model is presented in which functional lateral specialization and selective hemisphere priming combine to provide a mechanism for behavioral variability. the model is tested and supported by two experiments in which lateral attentional priming produces significant reductions in between-subject and within-subject variability. these findings help us to understand the source of behavioral variability, broaden our knowledge of the gross structures and functions of the brain, provide information ab ... | 1989 | 2657608 |
| [campylobacter pylori and pathology of the gastro-duodenal mucosa. critical review of clinico-experimental and therapeutic contributions]. | over the past five years, a series of important contributions have appeared in the medical literature on the role of infective agents in the pathogenesis of gastric and duodenal inflammation. the analysis of the available data confirms the possible role of campylobacter pylori in causing acute inflammation of the type b antral gastritis, although its role in the pathogenesis of gastric and duodenal ulcer and of the socalled non ulcer dyspepsia is still doubtful. not even the results of therapeut ... | 1989 | 2661960 |
| [infectious diarrhea diseases]. | gastroenteritis may be due to many agents, infectious or non infections. most cases of infections diarrhea are selflimited--e.g. food born intoxications with 1 to 2 days duration or infections with enteropathogenic e. coli, salmonella spp., vibrio parahaemolyticus or rota virus. even the majority of shigellosis, salmonella-gastroenteritis and infections with campylobacter fetus cease without treatment within 4 days. fever and diarrhea persisting for more than 4 days justify the use of antibiotic ... | 1989 | 2662618 |
| [susceptibilities of clinical isolates to antibacterial agents. a study mainly focused on ofloxacin (the second report). reported by the research group for testing ofloxacin susceptibility on clinical isolates]. | susceptibilities of various clinical isolates to ofloxacin (oflx) and other antibacterial drugs were examined at 128 hospital laboratories in 36 prefectures throughout japan between april, 1986 and march, 1987. the results were totalized with an emphasis mainly on oflx and were compared with data obtained in the previous year. in this study, identification and susceptibility tests of the isolates were carried out at each hospital laboratory and the tests were performed according to the 1-dilutio ... | 1989 | 2664255 |
| mechanics of the healed meniscus in a canine model. | the mechanical behavior of the intact canine stifle joint was studied, using a surgical model of meniscal injury and repair. thirty-eight animals were divided into five study groups: group s received only a sham arthrotomy (without a meniscal incision), groups p13 and p26 received peripheral medial meniscal incisions, and groups r13 and r26 received radial medial meniscus incisions. all meniscal incisions were repaired anatomically with absorbable suture. groups p13 and r13 were sacrificed at 13 ... | 1989 | 2667375 |
| a biotin-streptavidin amplified enzymeimmunoassay for 13,14-dihydro-15-keto-pgf2 alpha. | as an alternative for radioimmunoassays a new enzyme immunoassay (eia) for the determination of 13,14-dihydro-15-keto pgf2 alpha (pgfm) has been developed. biocytin was linked to pgfm by the n-hydroxysuccinimide method and the product (biocytinyl-pgfm) purified by reversed phase column chromatography. biocytinyl-pgfm was used in the eia as a bridge between the immobilized pgfm-antibody and streptavidin-peroxidase. the absolute sensitivity of the assay was about 160 amol (92% rel. binding) and re ... | 1989 | 2675197 |
| [antibacterial and bactericidal activities of japanese green tea]. | we found that extracts of japanese green tea leaves inhibited the growth of various bacteria causing diarrheal diseases. all tea samples tested showed antibacterial activity against staphylococcus aureus, s. epidermidis, vibrio cholerae o1, v. cholerae non o1. v. parahaemolyticus, v. mimicus, campylobacter jejuni and plesiomonas shigelloides. none of the tea samples had any effect on the growth of v. fluvialis, aeromonas sobria, a. hydrophila, pseudomonas aeruginosa, salmonella enteritidis, ente ... | 1989 | 2677434 |
| digit-muscle responses evoked from multiple intracortical foci in monkey precentral motor cortex. | 1. the precentral motor cortex, including the anterior bank of the central sulcus of monkey (macaca fuscata), was systemically penetrated with microelectrodes to determine the spatial organization of the microexcitable cortical elements that can produce responses in digit muscles. 2. at 200-microns intervals on each electrode track, low-current intracortical microstimuli were delivered and the muscle responses evoked from four digit muscles were recorded. the responses, obtained with 5, 8, 15, a ... | 1989 | 2681562 |
| [biological characteristics of plasmid carrying a repeated deoxyribonucleic acid sequence]. | it was found that a plasmid which had a foreign deoxyribonucleic acid (dna) between two repeated sequences did not multiply in e. coli recbcsbcb, even if it multiplied in wild-type e. coli, e. coli recbc or e. coli recbcsbcbrecf when the insert was longer than 351 base pair. the multiplication of these plasmids were, however, inhibited when a plasmid expressing recf gene was introduced into e. coli recbcsbcbrecf. the inviability of the plasmid carrying the repeated sequence in e. coli recbcsbcb ... | 1989 | 2681680 |
| immunocytochemical localization of glutamate decarboxylase in the mesothoracic ganglion of locusta migratoria. | glutamate decarboxylase immunoreactivity has been located in the thoracic ganglia of the locust, locusta migratoria, using an antiserum raised from rat brain. at the light microscopic level clusters of nerve cell somata as well as nerve fibres were positively labelled by the antiserum. electron microscopy showed that glutamic acid decarboxylase was localized in numerous synaptic terminals. | 1989 | 2686095 |
| mechanisms of resistance in anaerobes and new developments in testing. | anaerobic bacteria currently demonstrate increased resistance to antimicrobial agents, primarily by the production of beta-lactamase. a number of species of bacteroides, most notably those in the bacteroides fragilis group, produce these enzymes. a few species of fusobacterium and clostridium produce beta-lactamase as well. fortunately, this mechanism of resistance is readily overcome by administering beta-lactamase inhibitors coupled with a beta-lactam antibiotic that would otherwise be inactiv ... | 1989 | 2686914 |
| characterization of toxigenic vibrios isolated from the freshwater environment of hiroshima, japan. | the occurrence and characterization of toxigenic vibrios in surface water and sediment samples of the fresh water environment of the ohta river were studied. the membrane filter, pad preenrichment technique, followed by the placement of membranes onto thiosulfate citrate-bile salt-sucrose agar, was used for the enumeration of total vibrios. qualitative examination of pathogenic vibrios was also attempted. in addition, a survey was conducted to determine the incidence of clostridium botulinum in ... | 1989 | 2690736 |
| [transurethral unroofing of the müllerian duct cyst: a case report]. | management of müllerian duct cyst depends on the size and symptomatology. here we report a case of recurrent müllerian duct cyst which was treated successfully by transurethral approach. a 57-year-old man was first admitted because of dysuria in 1981. under the diagnosis of müllerian duct cyst, he underwent resection of the cyst by suprapubic retrovesical approach that resulted in incomplete extirpation. in 1982, he was readmitted for recurrence of the cyst. excision by transsacral approach was ... | 1989 | 2694830 |
| mechanism of lhrh-stimulated steroidogenesis in rat leydig cells: lipoxygenase products of arachidonic acid may not be involved. | luteinizing hormone releasing hormone agonist, [(imbzl)-dhis6,pro9,net]-lhrh (lhrh-a), caused a two to threefold increase in in vitro testosterone (t) secretion by rat leydig cells. this lhrh-a-induced t secretion was completely blocked by quinacrine and chloroquine, inhibitors of phospholipase a2. addition of phospholipase a2, however, was ineffective in stimulating basal or lhrh-a-induced t secretion. phospholipase c, on the other hand, significantly stimulated both basal and lhrh-a-induced t ... | 1989 | 2695506 |
| [specificity of action of metalloproteinases from buckwheat seeds. hydrolysis of insulin beta-chain]. | | 1989 | 2698338 |
| [hiv infection and aids in 1988. the epidemiological situation in norway]. | | 1989 | 2705132 |
| new techniques of analyzing the healing process of artificial vascular grafts, transmural vascularization, and endothelialization. | beside traditional techniques (light, immunofluorescence, transmission electron (tem)- and scanning electron microscopy (sem), a new more sensitive method for producing microcorrosion casts using a polyester-based resin has been developed. the sem analyses of the microcorrosion casts of alloplastic vascular grafts was realized in an absolutely stable stage of polymerization. for the first time, a transprosthetic vascularization could be shown in great three-dimensional detail. the importance of ... | 1989 | 2711038 |
| [acute gastroenteritis due to vibrio parahaemolyticus in spain. presentation of 8 cases]. | eight cases of acute gastroenteritis caused by vibrio parahaemolyticus in humans are described; to our knowledge, they are the first such reported cases in spain. all cases appeared between august 20th and october 15th, with a frequency of 8.3% regarding the overall adult patients with acute gastroenteritis, and 11.5% regarding the overall patients with positive stool culture for any enteropathogenic organism. the eight strains were kanagawa positive and in three patients other enteropathogenic ... | 1989 | 2716372 |
| [acute gastroenteritis due to vibrio parahaemolyticus. serotypes and presentation of 4 new cases]. | | 1989 | 2716381 |
| purification of a tdh-related hemolysin produced by a kanagawa phenomenon-negative clinical isolate of vibrio parahaemolyticus 06: k46. | a hemolysin produced by a clinical isolate of kanagawa phenomenon-negative vibrio parahaemolyticus 06: k46 was purified by 55% ammonium sulfate fractionation and successive column chromatographies on deae-cellulose, hydroxyapatite, sepharose 4b and mono q. the purified hemolysin was physicochemically and immunologically identical with the vp-trh (v. parahaemolyticus thermostable direct hemolysin related hemolysin) recently described in v. parahaemolyticus 03: k6 (honda et al. infect. immun. 56: ... | 1989 | 2721917 |
| vibrio parahaemolyticus and other halophilic vibrios associated with seafood in hong kong. | the summer prevalence of vibrio parahaemolyticus and other halophilic vibrios in seafood from hong kong markets was investigated. halophilic vibrios were isolated from all seven types of seafood examined, and comprised 9.1%, 8% and 6.1% of contaminating aerobic heterotrophic bacteria from mussels, clams and oysters respectively. sucrose-positive vibrios were more common than sucrose-negative varieties. vibrio alginolyticus was the most frequently isolated species, followed by v. parahaemolyticus ... | 1989 | 2722715 |
| role of extracellular space in hyperosmotic suppression of potassium-induced electrographic seizures. | 1. focal electrographic seizures arose in the ca1 region of rat hippocampal slices bathed in elevated (8.5 mm) external potassium [( k+]o). high [k+]o also induced spontaneous interictal bursts that originated in area ca3 and propagated to ca1. to examine the contribution to electrographic seizure initiation of excitatory mechanisms that are influenced by extracellular volume, we studied the effect of hyperosmotic expansion of interstitial volume on seizure occurrence, interictal bursts, and exc ... | 1989 | 2723735 |
| primary structures of sm31/32 diagnostic proteins of schistosoma mansoni and their identification as proteases. | we have constructed cdna clones containing the complete nucleotide sequences coding for two highly antigenic schistosoma mansoni adult worm proteins, sm31 and sm32. the predicted amino acid sequence of sm31 shows significant homology to mouse, rat and human cathepsin b. the nucleotide sequence of sm32 is identical to that reported by others for s. mansoni "haemoglobinase'. the different nucleotide sequences demonstrate the existence of two different proteolytic enzymes, both of which are synthes ... | 1989 | 2725581 |
| in vivo dna cross-linking by cyclophosphamide: comparison of human chronic lymphatic leukemia cells with mouse l1210 leukemia and normal bone marrow cells. | alkaline elution was done on a variety of cells following cyclophosphamide (cy) treatment in vivo. cells used were l1210 leukemia, normal mouse bone marrow, and peripheral blood cells obtained from a patient with chronic lymphatic leukemia (cll). endpoints used were determination of single strand breaks, dna-dna interstrand and dna-protein cross-links. after treatment of mice with cy (4 mg/mouse), low levels of single strand breaks were observed in both l1210 leukemia and cdf1 normal bone marrow ... | 1989 | 2731167 |
| ventricular arrhythmias and local electrograms after chronic regional denervation of the ischemic area in the pig heart. | cardiac denervation has been proved to reduce the incidence of coronary occlusion arrhythmias in digs, but the effect of limiting the extent of sympathectomy to the ischemic area, particularly in hearts with sparse coronary collateral circulation, as in the human heart, needs further investigation. ventricular arrhythmias and changes in epicardial direct current electrograms induced during acute left anterior descending coronary artery occlusion were recorded in 14 pigs subjected to regional den ... | 1989 | 2738265 |
| bronchoconstrictor action of neuropeptide y (npy) in isolated guinea pig airways. | responses of various preparations of guinea pig and rat airways to synthetic porcine neuropeptide y were analysed in vitro. npy in doses up to 10(-6) m, induced a dose dependent contraction in trachea, bronchi and lung parenchymal strips of the guinea pig but did not have any effect in similar preparations obtained from the rat. in guinea pig airways the contractile responses to npy were small in size and characterized by a slow onset and a long duration. this effect of the peptide was not depen ... | 1989 | 2747854 |
| identification and characterization of an 8-kd peptide stimulating late erythropoiesis. | chronic renal failure is often associated with severe anemia, subnormal levels of erythropoietin (epo), and the presence of erythropoietic inhibitors. we studied an anephric patient with polycystic kidney disease maintaining a hemoglobin level of 13-14 g. biochemical, endocrine, and hematological parameters were all within normal limits. epo levels examined on two occasions during the clinical investigation were found to be low to subnormal. plasma of this patient supported human bone marrow ery ... | 1989 | 2753086 |
| 3'-fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-hiv-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues. | a series of 2'- and 3'-fluorinated 2',3'-dideoxynucleosides and 3'-azido-2',3'-dideoxynucleosides were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus-1 (hiv-1) replication in mt-4 cells. neither conversion of 3'-fluoro- or 3'-azido-2',3'-dideoxyadenosine to the corresponding inosine derivatives nor 8-bromination of 2',3'-dideoxyadenosine resulted in increased anti-hiv-1 activity. nor did introduction of a 2'-fluorine in the erythro or threo configura ... | 1989 | 2754700 |
| cloning and nucleotide sequence of the gene (trh) encoding the hemolysin related to the thermostable direct hemolysin of vibrio parahaemolyticus. | vibrio parahaemolyticus isolates derived from an outbreak of gastroenteritis in the republic of maldives did not have the genetic potential to produce the thermostable direct hemolysin, but one such isolate produced a hemolysin immunologically related to the thermostable direct hemolysin (t. honda, y. ni, and t. miwatani, infect. immun. 56:61-965, 1988). the maldives isolates hybridized with the dna probe for the gene encoding the thermostable direct hemolysin (the tdh gene) under reduced string ... | 1989 | 2759706 |
| compartmentalizing chemomechanical transduction in the ejecting heart. | the efficiency of transferring the total energy generated by ventricular contraction (pressure-volume area, pva) to external work (ew) and internal work (iw) and the myocardial oxygen consumption (mvo2) at zero pva were determined during volume loading on right heart bypass before and after a 50% augmentation (cacl2, 0.03 meq/kg/min, n = 7) or depression (20 minutes of 37 degrees c ischemia with 30 minutes of reperfusion, n = 7) of the contractile state. an increased ew efficiency (64% +/- 7% vs ... | 1989 | 2763028 |
| [prospects for measuring the rheologic characteristics of human soft tissues based on the recording of their transverse rigidity]. | it is shown by an example of a forearm that to determine objective characteristics of rheological properties of soft human tissues by measuring their transverse stiffness (k) one should first investigate the relation between k and the diameter of the used indentor (d). the nonlinearity of the dependence k(d) for indentor diameters from 2 to 8 mm is demonstrated and it is assumed that this nonlinearity is due to heterogeneity of tissue properties in the directions normal to the axis of force acti ... | 1989 | 2765581 |
| endothelium-dependent inhibition of ergonovine-induced contraction is impaired in porcine coronary arteries with regenerated endothelium. | the inhibitory effects of the endothelium against ergonovine-induced contraction were examined in isolated porcine coronary arteries under normal conditions and after endothelial regeneration. endothelium-dependent responses were examined in vitro in normal yorkshire pigs (n = 16) and in pigs that had undergone balloon endothelium removal of the left anterior descending coronary artery (lad) 4 weeks before the study (n = 10). the presence of a complete endothelial lining was confirmed histologic ... | 1989 | 2766515 |
| transcriptional start site in the mouse cyp1a1 (cytochrome p1450) gene. | two transcriptional initiation sites have been described by different laboratories for the mouse cyp1a1 (cytochrome p1450) gene: start site ti, at the beginning of the nontranslated 87-bp first exon, and start site tii, 635 bp downstream from site ti within the 2,380-bp first intron. site ti was characterized in normal c57bl/6 mouse liver, whereas site tii was described in a high activity variant line (hav cells) derived from the mouse hepatoma hepa-1c1c7 wild type (wt) established cell line. it ... | 1989 | 2766934 |
| serovars of vibrio parahaemolyticus. | seashore water samples collected along the coastline in bulgaria and rumania contained in large numbers ok serovars of v. parahaemolyticus; some of these had been isolated repeatedly over an extended time period: 01 k32, 03 k30, 03 k48, 04 k37, 04 k53, 05 k17, 05 k30. the serovar 05 k17 was virtually present in all water samples and was also isolated from a case of purulent ear infection in a child from burgas. in contrast, strains recovered from asian and african coastal water had different k a ... | 1989 | 2768821 |
| studies in fetal wound healing: ii. a fetal environment accelerates fibroblast migration in vitro. | we have used an in vitro model of wound healing using scratches made in a confluent monolayer of fibroblasts. the effects of fetal calf and postnatal calf serum on the migration of fibroblasts were compared. differences between fetal and calf serum-incubated fibroblasts grown on coverslips were observed within 15 minutes of exposure. cells in fetal serum began to change both shape and orientation and to move into the trough created by the scratch. the fibroblasts incubated in fetal calf serum co ... | 1989 | 2769548 |
| studies in fetal wound healing: ii. a fetal environment accelerates fibroblast migration in vitro. | we have used an in vitro model of wound healing using scratches made in a confluent monolayer of fibroblasts. the effects of fetal calf and postnatal calf serum on the migration of fibroblasts were compared. differences between fetal and calf serum-incubated fibroblasts grown on coverslips were observed within 15 minutes of exposure. cells in fetal serum began to change both shape and orientation and to move into the trough created by the scratch. the fibroblasts incubated in fetal calf serum co ... | 1989 | 2769548 |
| [complete occlusion both left main coronary artery and right coronary artery]. | a 67-year-old man, who had complete occlusion both of left main coronary artery (lmca) and right coronary artery (rca), underwent coronary revascularization. he had been suffering from severe angina pectoris preoperatively. exercise electrocardiogram (single master) showed myocardial ischemia. on cardiac catheterization, he showed extensive collaterals from right main coronary artery, and well-preserved left ventricular function. at operation, coronary arteries revealed severe sclerosis, especia ... | 1989 | 2770071 |
| [cardiovascular risk factors in children and adolescents in fuenlabrada: objectives, features of the population, design, participation, equipment, laboratory technics, and quality control]. | fuenlabrada is at the present time the most industrialized town placed at the south are of madrid. this population has some peculiar attractive characteristics from the epidemiologic point of view. perhaps the most important is that the majority of its inhabitants are immigrant from other depressed rural areas of the country, with a low socio-economic and cultural level. the new conditions of life could have changed the life expectation and the causes of morbidity and mortality of this populatio ... | 1989 | 2772364 |
| characterization of a non-structural 147-kda precursor polypeptide of echovirus 33 and its immunogenicity in man. | zinc chloride (0.9 mm)--an inhibitor of the processing of the initial polypeptides of picornaviridae--was used to accumulate large precursors of echovirus 33 (ev33) and notably two proteins of 147- and 97-kda. polyclonal hyperimmune sera were raised in mice against these polypeptides and assayed by immunoblotting against ev33-infected cells blocked or not with zncl2, showing that protein 147--2abc3abcd according to the l434 convention--can be considered to be the precursor of the two non-structu ... | 1989 | 2772414 |
| heterosexual spread of hiv infection. | | 1989 | 2772471 |
| [prevalence of vibrio parahaemolyticus in seafood from restaurants in the city of mérida, yucatán]. | we report the prevalence of the vibrio parahaemolyticus in raw (11.54%), insufficiently cooked (0.00%) and partially cooked with heat (4.55%) sea foods, from restaurants of the city of merida, yucatan, mexico. we studied 190 samples from march to august 1987. we isolated 12 strains (6.32%) from an equal number of samples, whose biochemical characteristics corresponded with vibrio parahaemolyticus. we didn't find significant statistically differences when we compared the prevalences of the sample ... | 1989 | 2772734 |
| primary structure of a novel 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid (sits)-binding membrane protein highly expressed in torpedo californica electroplax. | polyclonal rabbit antibodies were raised against 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid (sits), an inhibitor of a variety of anion transport proteins. these antibodies specifically recognize sits-reacted erythrocyte band 3 in immunoprecipitations and western blots. in western blots of sits-reacted membrane proteins derived from vesicles of the electric organ of torpedo californica (known to express a sits-sensitive cl- channel) the antibodies recognized two major species of ap ... | 1989 | 2775201 |
| isolation and identification of 3-deoxy-d-threo-hexulosonic acid as a constituent of the lipopolysaccharide of vibrio parahaemolyticus serotypes o7 and o12. | treatment of the lipopolysaccharide of vibrio parahaemolyticus serotypes o7 and o12 with mild acid gave a compound which, on the basis of chemical analysis, g.l.c.-m.s., and 1h and 13c-n.m.r. spectroscopy, was characterized as 3-deoxy-d-threo-hexulosonic acid and shown to be present as a terminal non-substituted pyranose unit. | 1989 | 2776131 |
| production of monoclonal antibodies against thermostable direct hemolysin of vibrio parahaemolyticus and application of the antibodies for enzyme-linked immunosorbent assay. | a total nine hybridoma cell lines that produced monoclonal antibodies against thermostable direct hemolysin (vp-tdh), a possible pathogenic toxin, of kanagawa phenomenon-positive vibrio parahaemolyticus was isolated and characterized. these monoclonal antibodies (mabs) were divided into a minimum of five different specificity groups, including mabs specific to vp-tdh and common to vp-tdh and vp-trh, a vp-tdh-related hemolysin produced by kanagawa phenomenon-negative v. parahaemolyticus. an enzym ... | 1989 | 2779485 |
| comparison of vibrio parahaemolyticus grown in estuarine water and rich medium. | cell envelope composition and selected physiological traits of vibrio parahaemolyticus were studied in regard to the kanagawa phenomenon and growth conditions. cell envelopes were prepared from cells cultured in proteose peptone-beef extract (difco laboratories, detroit, mich.) medium or filtered estuarine water. protein, phospholipid, and lipopolysaccharide contents varied with culture conditions. the phospholipids present in the cell envelopes were identified as phosphatidylethanolamine, phosp ... | 1989 | 2782869 |
| neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type a. | moclobemide belongs to a new generation of short-acting, reversible, monoamine oxidase (mao) inhibitors. in vitro (rat brain homogenates) moclobemide inhibits mao-a selectively with lower potency than many of the reference mao inhibitors. however, when measured ex vivo in the rat, the potency of moclobemide is similar to that of reference compounds. in vivo the drug induces a dose-dependent, short-lasting (8-16 hr) and preferential inhibition of mao-a in the brain and both mao-a and mao-b inhibi ... | 1989 | 2783611 |
| neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type a. | moclobemide belongs to a new generation of short-acting, reversible, monoamine oxidase (mao) inhibitors. in vitro (rat brain homogenates) moclobemide inhibits mao-a selectively with lower potency than many of the reference mao inhibitors. however, when measured ex vivo in the rat, the potency of moclobemide is similar to that of reference compounds. in vivo the drug induces a dose-dependent, short-lasting (8-16 hr) and preferential inhibition of mao-a in the brain and both mao-a and mao-b inhibi ... | 1989 | 2783611 |
| reversal of natural killing susceptibility in target cells expressing transfected class i hla genes. | a number of studies have suggested that resistance of target cells to natural killing (nk) may be correlated with their level of expression of major histocompatibility complex (mhc) class i antigens. to examine this hypothesis directly, a nk-sensitive class i-deficient human b-cell line was transfected with mhc class i genes. the expression of transfected hla, but not h-2, class i gene products resulted in loss of susceptibility to human nk-mediated conjugation and cytolysis. furthermore, this p ... | 1989 | 2784569 |
| induction of the insulin receptor and other differentiation markers by sodium butyrate in the burkitt lymphoma cell, raji. | the very low expression of insulin receptors in the burkitt lymphoma cell raji was increased 2-fold, 6-fold and 10-fold after 1, 2 and 3 days, respectively, by incubation with the differentiation inducer sodium butyrate. insulin receptor number was increased without a change in receptor affinity, in association with an increase in the receptor alpha and beta subunits detected after cell-surface labelling and immunoprecipitation. expression of cell-surface class i and ii human leukocyte antigens, ... | 1989 | 2786417 |
| human t lymphocytes possess a limited in vitro life span. | the t lymphocyte offers certain theoretical advantages over other available cell types for the study of aging. immunosenescence is a well-established part of, and may be directly relevant to, mammalian aging, and the t lymphocyte is well-characterized as to function, cell-surface antigen make-up, and other factors. however, prior efforts at studying in vitro aging of t cells have been hampered by poor reproducibility in doubling potential and the occurrence of a peculiar type of crisis. we have ... | 1989 | 2786475 |
| effect of protein kinase c inhibitor (h-7) and calmodulin antagonist (w-7) on pertussis toxin-induced il-1 production by human adherent monocytes. comparison with lipopolysaccharide as a stimulator of il-1 production. | human adherent monocytes stimulated with 1 microgram/ml pertussis toxin (pt) produced interleukin-1 (il-1), as measured by thymocyte co-stimulation assay and enzyme-linked immunosorbent assay (elisa), specific for il-1 alpha and il-1 beta. to clarify the role of protein kinase c (pkc) and calmodulin in il-1 production, we investigated the effects of a pkc inhibitor, h-7, and a calmodulin antagonist, w-7 on pt- and lipopolysaccharide (lps)-induced il-1 production by monocytes. addition of 10 micr ... | 1989 | 2787778 |
| synergistic antitumor effects of interleukin 2 and the monoclonal lym-1 against human burkitt lymphoma cells in vitro and in vivo. | interleukin 2 (il-2) regulates immune responses by inducing proliferation and differentiation of t-cells into cytotoxic cells, inducing lymphokine activated killer activity and enhancing antibody dependent cellular cytotoxicity (adcc). lym-1, a monoclonal antibody, recognizes a membrane antigen present on the surface of b-lymphoma cells and can be used for adcc. we therefore used raji (human burkitt lymphoma) cells to study the efficacy of combination therapy with il-2, lymphokine activated kill ... | 1989 | 2788499 |
| effect of vitamin d metabolites on calcitriol metabolism in experimental renal failure. | previous studies from our laboratory have demonstrated that metabolic clearance rate (mcr) of calcitriol is decreased in experimental renal failure. in this experiment, we examined the effects of calcitriol, 25-hydroxyvitamin d3 (25(oh)d3) and 24,25-dihydroxyvitamin d3 (24,25(oh)2d3) on the mcr of calcitriol in renal failure produced in rats by partial nephrectomy. the mcr of calcitriol in these rats with renal failure was significantly lower than in control rats with sham operations. plasma con ... | 1989 | 2789310 |
| [an autopsy case of vibrio parahaemolyticus sepsis]. | | 1989 | 2794678 |
| non-suppurative bacterial arthritis diagnosed by fine-needle aspiration biopsy. | | 1989 | 2799306 |
| [the effect of progesterone, testosterone and estradiol on steroid hormone release by the ovarian follicles of cows in vitro]. | | 1989 | 2806660 |
| light and electronmicroscopic examination of calf lung tissue after left ventricular assisted circulation with the spindle pump. | the influence of the spindle pump, a nonpulsatile blood pump, used as lvad on calf lung tissue was examined by means of the actual 16th protoype which was applied in 3 "acute" tests up to 13 hours of pumping duration and 8 prolonged experiments with pumping periods up to 63 hours. samples were taken during the operation and after exitus of the test animal and investigated by light and electronmicroscopy. histological findings of tissue changes could be ascribed to mechanical manipulations and sh ... | 1989 | 2807590 |
| light and electronmicroscopic examination of calf lung tissue after left ventricular assisted circulation with the spindle pump. | the influence of the spindle pump, a nonpulsatile blood pump, used as lvad on calf lung tissue was examined by means of the actual 16th protoype which was applied in 3 "acute" tests up to 13 hours of pumping duration and 8 prolonged experiments with pumping periods up to 63 hours. samples were taken during the operation and after exitus of the test animal and investigated by light and electronmicroscopy. histological findings of tissue changes could be ascribed to mechanical manipulations and sh ... | 1989 | 2807590 |
| serological screening for a mucine-like carcinoma-associated antigen (mca) in patients with gastrointestinal tract malignancies. | mouse monoclonal antibody b-12 identifies a high-molecular-mass glycoprotein antigen strongly expressed by breast carcinoma cells. since immunohistochemical studies have also demonstrated some reactivity with other epithelial neoplasms, and since "mucine-like carcinoma-associated antigen" (mca) has gained considerable interest as a tumor marker in breast cancer, we have investigated 34 patients with histologically proven advanced gastrointestinal malignancies for the presence of elevated mca ser ... | 1989 | 2808488 |
| [visualization of forensically important foreign bodies by direct roentgen magnification]. | the detection of foreign bodies of microscopic dimensions with radiographic techniques is limited by the size and density of the particle and the radiographic resolution. these restrictions can be of decisive value in case work. the high grade direct radiographic magnification technique was successfully used in preceding experiments. due to its 1 mu focal spot, this tube allows direct magnifications up to 250 times. in present studies, the advantages as well as the limitations of this new techni ... | 1989 | 2818477 |
| [visualization of forensically important foreign bodies by direct roentgen magnification]. | the detection of foreign bodies of microscopic dimensions with radiographic techniques is limited by the size and density of the particle and the radiographic resolution. these restrictions can be of decisive value in case work. the high grade direct radiographic magnification technique was successfully used in preceding experiments. due to its 1 mu focal spot, this tube allows direct magnifications up to 250 times. in present studies, the advantages as well as the limitations of this new techni ... | 1989 | 2818477 |
| reaction of tryptophanyl-trna synthetase from beef pancreas with periodate-oxidized atp. | tryptophanyl-trna synthetase from beef pancreas reacts with periodate-oxidized atp according to biphasic kinetics. a rapid phase involves two groups of the protein, presumably lysine side-chains. the slow phase corresponds to the reaction of a larger number of groups. the time-course of the partial losses of the atp-ppi isotopic exchange and of the aminoacylation activities of the enzyme follow the labelling of the two fast-reacting groups. however, the ability of the enzyme to form a bis(trypto ... | 1987 | 2820730 |
| formation of mboii vectors and cassettes using asymmetric mboii linkers. | class-iis restriction endonucleases such as mboii cleave dna at a specified distance away from their recognition sequences. this feature was exploited to cleave dna at previously inaccessible locations by preparing special asymmetric linker/adapters containing the mboii recognition sequence. these could be joined to dna fragments and subsequently cleaved by mboii. attachment of a 3' phosphate to one of the two different oligodeoxynucleotides comprising the asymmetric duplex prevented ligation at ... | 1987 | 2820843 |
| formation of mboii vectors and cassettes using asymmetric mboii linkers. | class-iis restriction endonucleases such as mboii cleave dna at a specified distance away from their recognition sequences. this feature was exploited to cleave dna at previously inaccessible locations by preparing special asymmetric linker/adapters containing the mboii recognition sequence. these could be joined to dna fragments and subsequently cleaved by mboii. attachment of a 3' phosphate to one of the two different oligodeoxynucleotides comprising the asymmetric duplex prevented ligation at ... | 1987 | 2820843 |
| type beta transforming growth factor affects adrenocortical cell-differentiated functions. | type beta transforming growth factor (tgf-beta) had no detectable effect on mitogenic activities of bovine adrenocortical cells in culture. however, the presence of tgf-beta (1 ng/ml) in the medium resulted in a striking alteration of adrenocortical cell steroidogenic activities, maximally expressed after 18-20 h of treatment. tgf-treated cells exhibited a basal as well as an adrenocorticotropin-stimulated cortisol production inhibition by an average 50-60%, while camp accumulation in response t ... | 1987 | 2820972 |
| type beta transforming growth factor affects adrenocortical cell-differentiated functions. | type beta transforming growth factor (tgf-beta) had no detectable effect on mitogenic activities of bovine adrenocortical cells in culture. however, the presence of tgf-beta (1 ng/ml) in the medium resulted in a striking alteration of adrenocortical cell steroidogenic activities, maximally expressed after 18-20 h of treatment. tgf-treated cells exhibited a basal as well as an adrenocorticotropin-stimulated cortisol production inhibition by an average 50-60%, while camp accumulation in response t ... | 1987 | 2820972 |
| experimental transmission and pathogenesis of immunodeficiency syndrome in cats. | we describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as felv-faids) which induces fatal acquired immunodeficiency syndrome (aids) in 100% (25 of 25) of persistently viremic experimentally infected specific pathogen-free (spf) cats after predictable survival periods ranging from less than 3 months (acute immunodeficiency syndrome) to greater than one year (chronic immunod ... | 1987 | 2823940 |
| experimental transmission and pathogenesis of immunodeficiency syndrome in cats. | we describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as felv-faids) which induces fatal acquired immunodeficiency syndrome (aids) in 100% (25 of 25) of persistently viremic experimentally infected specific pathogen-free (spf) cats after predictable survival periods ranging from less than 3 months (acute immunodeficiency syndrome) to greater than one year (chronic immunod ... | 1987 | 2823940 |
| genetic and physical characterization of proba genes of the marine bacterium vibrio parahaemolyticus. | intracellular proline pools have been implicated in the halotolerance of many organisms. to examine this relationship in a moderately halotolerant marine bacterium, vibrio parahaemolyticus, proline biosynthesis genes were cloned in various plasmids. some genetic and structural properties of those genes were examined. subcloning showed that about 3.1 kilobases of v. parahaemolyticus dna could complement proa and prob but not proc mutations of escherichia coli. the same fragment would also complem ... | 1987 | 2829719 |
| properties of adenosine triphosphate-hydrolyzing enzymes in membrane vesicles of vibrio parahaemolyticus. | | 1987 | 2830036 |
| mononuclear cell infiltration in central portions of human astrocytomas. | the mononuclear cell infiltration in the central portion of human low- and high-grade astrocytomas has been examined using monoclonal antibodies to cell surface differentiation antigens. there was no significant difference between the number of t cells, b cells, or macrophages. the okt8+ (suppressor/cytotoxic) t cell population was the major lymphocyte subset in the infiltrates. there was, however, indirect evidence for a proportion of the total okt8+ cells being natural killer cells. overall, t ... | 1988 | 2830373 |
| mononuclear cell infiltration in central portions of human astrocytomas. | the mononuclear cell infiltration in the central portion of human low- and high-grade astrocytomas has been examined using monoclonal antibodies to cell surface differentiation antigens. there was no significant difference between the number of t cells, b cells, or macrophages. the okt8+ (suppressor/cytotoxic) t cell population was the major lymphocyte subset in the infiltrates. there was, however, indirect evidence for a proportion of the total okt8+ cells being natural killer cells. overall, t ... | 1988 | 2830373 |
| prevalence of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome. | we studied 388 homosexual or bisexual men from the baltimore-washington area to define the spectrum of enteric pathogen carriage in a population at high risk for "gay bowel syndrome" in association with human immunodeficiency virus infection. seventy-seven patients with acquired immunodeficiency syndrome, 68 gay men with symptoms of acute diarrhea or proctitis, and 243 gay men without gastrointestinal symptoms and participating in a natural history study of human immunodeficiency virus infection ... | 1988 | 2831107 |
| characterization and mapping of the agrocinopine-agrocin 84 locus on the nopaline ti plasmid ptic58. | overlapping segments of ptic58 inserted into cosmid vectors were used to characterize the agrocinopine-agrocin 84 locus from the nopaline/agrocinopine a and b agrobacterium tumefaciens strain c58. all of the clones conferring agrocin 84 sensitivity on agrobacteria also conferred uptake of agrocin 84 and agrocinopines a and b. transposon tn3-hoho1 insertion mutations of one such clone were generated that simultaneously abolished agrocin 84 sensitivity and transport of agrocinopines a and b and ag ... | 1988 | 2832379 |
| properties of the membrane-bound 5'-nucleotidase and utilization of extracellular atp in vibrio parahaemolyticus. | vibrio parahaemolyticus utilized atp, adp or amp as the sole source of carbon. about three times higher activity of membrane-bound 5'-nucleotidase was observed in cells grown in the presence of these nucleotides than in their absence: and therefore the enzyme seems to be inducible. since the 5'-nucleotidase activity could be measured with whole cells, the active site of this enzyme appears to be outwardly oriented. both mg2+ and cl- were required for activity. among the divalent cations tested, ... | 1987 | 2835422 |
| [an epidemic of diarrhea caused by vibrio parahaemolyticus occurring in abidjan in 1985]. | the authors report the epidemiological results of an epidemic about 84 choleriform syndrome in abidjan (ivory coast), june 1985. | 1987 | 2836102 |
| human cytomegalovirus-associated dnase and the specific immune response in different clinical conditions. | | 1988 | 2837245 |
| mechanism of the epsp synthase catalyzed reaction: evidence for the lack of a covalent carboxyvinyl intermediate in catalysis. | in order to detect covalent reaction intermediates in the 5-enolpyruvylshikimate-3-phosphate (epsp) synthase reaction, we have investigated the interaction of epsp synthase with the reaction product epsp. an exchange of epsp-methylene protons could be demonstrated by incubating epsps with epsp in d2o. since trace amounts of contaminating pi would lead to reversal of epsps reaction and hence methylene proton exchange, we added pyruvate kinase, adp, mg++ and k+. under these conditions, any contami ... | 1988 | 2838023 |
| egg shell quality and cholecalciferol metabolism in aged laying hens. | calcium-binding protein d28k (calbindin) synthesis, vitamin d metabolism and shell quality were investigated in young and aged laying hens fed diets containing either cholecalciferol (cc) or its 1-hydroxylated derivatives. duodenal calbindin concentration was similar in the young and in the aged laying hens. exogenous 1-hydroxylated cc derivatives increased duodenal calbindin concentration, regardless of age. shell weight and shell density (mg/cm2) were significantly lower (p less than 0.01) in ... | 1988 | 2841436 |
| detection of leukotriene b4 in cardiac tissue and its role in infarct extension through leucocyte migration. | the main left coronary artery of rats was ligated near its origin under light ether anaesthesia and the infarction observed for 48 h. the ischaemic area was determined after an intravenous injection of pontamine sky blue dye 1 h before induction of cardiac arrest with potassium chloride. the unstained area (true ischaemic area) decreased with time to 27.1% of the left ventricle at 48 h, whereas the intensely stained area between the normal and the true ischaemic areas increased with time, sugges ... | 1988 | 2844405 |
| modulation of phosphoinositide hydrolysis by naf and aluminum in rat cortical slices. | naf stimulated phosphoinositide hydrolysis in rat cortical slices. the production of [3h]inositol monophosphate was rapid for the first 15 min of incubation with naf, followed by a plateau. the major product detected was [3h]inositol monophosphate, although significant amounts of [3h]inositol bisphosphate and [3h]inositol trisphosphate were also produced. the stimulation of [3h]inositol monophosphate production by naf was concentration dependent between 2 and 20 mm naf. addition of 10 or 100 mic ... | 1988 | 2846782 |
| influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines. | sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ... | 1988 | 2847397 |
| the potassium channel opening action of pinacidil; studies using biochemical, ion flux and microelectrode techniques. | in rat aorta and rat portal vein, (-)- and (+)-pinacidil each produced a concentration-dependent inhibition of tension development. although the (-) isomer was the more potent, concentration effect curves for each isomer were steep with similar slopes. in rat portal vein, tetraethylammonium and procaine antagonised the relaxant effect of (+/-)-pinacidil, whereas 3,4-diamino-pyridine was without effect. intracellular microelectrode recording in rat portal vein showed that low concentrations of (+ ... | 1988 | 2848206 |
| factors influencing the severity of escherichia coli and avian adenovirus group ii infections in chickens. | chickens from lines selectively bred for either a high (hh) or low (ll) antibody response to sheep erythrocytes were challenged intravenously with avian adenovirus group ii (aa). spleen size was determined 6 days later. in some experiments the responses of chickens to aa and escherichia coli infections were compared. the level of corticosterone in the feed (15 mg/kg) which resulted in the lowest incidence of pericarditis in response to e. coli resulted in the greatest incidence of large spleens ... | 1988 | 2849405 |
| plasma from uninephrectomized rats stimulates production of inositol trisphosphates and inositol tetrakisphosphate in renal cortical slices. | metabolism of inositol phosphates in renal cortical slices was investigated in vitro after addition of plasma from uninephrectomized or sham-operated rats. plasma from uninephrectomized rats stimulated production of insp3 (inositol trisphosphate) when obtained within the first 3 h after uninephrectomy. with different amounts of added plasma a graded response of insp3 production was obtained. this effect could be prevented by 0.1 microm-tpa (12-o-tetradecanoylphorbol 13-acetate). when analysis of ... | 1988 | 2849423 |
| kininase ii from human seminal plasma. isolation and properties. | a rapid and highly efficient procedure for purification of kininase ii from human seminal plasma is described. after ultra centrifugation, the enzyme was purified by gel filtration on sepharose 6b cl and ion exchange chromatography followed by affinity chromatography of edta-inhibited enzyme on bradykinin-sepharose. the enzyme was specifically inhibited by captopril and bpp9a but not by phosphoramidon. page in the presence of sodium dodecyl sulfate under reducing conditions resulted in two major ... | 1988 | 2849459 |
| suppression of sv40-promoted gene expression by differentiation of preadipose cells. | when a plasmid bearing the chloramphenicol acetyltransferase (cat) gene under the control of an sv40 early promoter is introduced into preadipose or adipose cells of line 3t3-f442a, the promoter directs high levels of transient expression of cat. however, when the plasmid is introduced into preadipose cells and the cells are then allowed to differentiate into adipose cells, the expression of the cat gene is suppressed. in this process, the plasmid is not changed detectably in amount, topology, o ... | 1988 | 2849579 |
| an immunohistochemical evaluation of c-erbb-2 expression in human breast carcinoma. | the c-erbb-2 gene codes for a putative transmembrane protein, similar in structure to the epidermal growth factor (egf) receptor. amplification of the gene has been described in a variety of human adenocarcinomas and is particularly well documented in breast carcinoma. it has been suggested that amplification is indicative of poor prognosis and, as such, is comparable with lymph node status as a predictor of clinical outcome. this study examines the suggestion indirectly by an immunohistochemica ... | 1988 | 2849974 |
| thermostable direct hemolysin of vibrio parahaemolyticus. | | 1988 | 2852761 |
| establishment and characterization of an epstein-barr virus negative b-cell lymphoma cell line and successful heterotransplantation. | an ebv-negative b-cell lymphoma cell line designated as hbl-1 was established from the pleural effusion of a patient with malignant lymphoma, diffuse, large cell. surface marker studies revealed that hbl-1 cell possessed the same phenotypes of a mature b-cell as the original lymphoma cell from pleural effusion. hbl-1 closely resembled morphologically to the original lymphoma cells observed in the lymph node biopsy and pleural effusion. chromosome analysis revealed that hbl-1 cells showed chromos ... | 1988 | 2854303 |
| polymicrobial aetiology of travellers' diarrhoea. | of 35 us peace corps volunteers in thailand, 20 (57%) had a total of 30 episodes of diarrhoea during their first 6 weeks in the country. enteric pathogens were associated with 90% of the episodes. a single pathogen was identified in 17 (57%) episodes, 2-4 pathogens were identified in 10 (33%) episodes, and there were 15 symptomless infections. enterotoxigenic escherichia coli (etec) was identified in 37% of these episodes, and various salmonella serotypes were isolated in 33%. infections with 9 ... | 1985 | 2857430 |
| benzodiazepines enhance the muscimol-dependent activation of phospholipase a2 in glioma c6 cells. | glioma c6 cells were incubated with [14c]arachidonate to label membrane phospholipids. muscimol, a selective gamma-aminobutyric acid a receptor agonist, but not (-)-baclofen, a selective gamma-aminobutyric acid b receptor agonist, stimulates [14c]arachidonate release from c6 cells as a result of hydrolysis of a small pool of phosphatidylcholine and phosphatidylethanolamine by phospholipase a2. this release is facilitated by diazepam and a number of other benzodiazepines such as flunitrazepam, me ... | 1985 | 2857784 |
| isolation of astrocytes, neurons, and synaptosomes of rat brain cortex: distribution of enzymes of glutamate metabolism. | a simplified method was developed for the bulk separation of neuronal perikarya and astroglial cells from adult rat brain without the involvement of density gradients. activities of various enzymes involved in glutamate metabolism were estimated and compared with those of synaptosomes. the activities of glutamate dehydrogenase and aspartate aminotransferase were higher in synaptosomes than in neuronal perikarya or glia. glutamine synthetase was distributed in all the three fractions while glutam ... | 1985 | 2859536 |
| photolabeling of mitochondrial f1-atpase by an azido derivative of the oligomycin-sensitivity conferring protein. | an azido derivative of the oligomycin sensitivity conferring protein (oscp) was prepared by alkylation with the bifunctional reagent p-azido phenacyl bromide. azido-oscp was fully biologically active in the dark. upon photoirradiation of a mixture of beef heart mitochondrial f1-atpase and azido-oscp, the resulting covalent photoproducts were separated by polyacrylamide gel electrophoresis in the presence of na dodecyl sulfate and characterized by an immunochemical procedure. oscp was found to re ... | 1985 | 2861814 |
| non-o1 vibrio cholerae produces two newly identified toxins related to vibrio parahaemolyticus haemolysin and escherichia coli heat-stable enterotoxin. | | 1985 | 2862364 |
| lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein. | lymphatic uptake of sodium cefoxitin after injection into rectal connective tissue was greater than after injection into the femoral muscle of rats. coadministration with sodium 5-methoxysalicylate enhanced lymphatic drug uptake at both sites. this enhancement may be an indirect result of 5-methoxysalicylate's suppression of vascular permeation of the cefoxitin. an adjuvant-induced increase in lymphatic fluid flow may also be partially involved in the enhancement of cefoxitin lymphatic transport ... | 1985 | 2863362 |
| [physiological and pharmacologic studies of the adrenal medulla by the measurement of plasma catecholamine levels]. | the new techniques for the assay of the plasma catecholamines: noradrenaline, dopamine and, most importantly, adrenaline, because of their sensitivity and precision, have provided new information about the physiology and the pharmacology of the adrenal medulla in animals and in man. the most effective of these new techniques are the radioenzymatic techniques. the activation of the adrenal medulla in the dog or the rat appears to be frequency-dependent by maintaining a fixed concentration ratio i ... | 1985 | 2863423 |