| hepatitis b antigens: separation of two populations differing in particle size distribution. | | 1973 | 4733164 |
| stimulation of growth of new axonal sprouts from lesioned monoamine neurones in adult rat brain by nerve growth factor. | | 1973 | 4744759 |
| autofluorescence of isolated unfixed rabbit deiters' neurons and surrounding neuroglial clamps. | | 1973 | 4744864 |
| morphological surface changes in the terminal bronchiolar region of no2-exposed rat lung. | | 1973 | 4745370 |
| aflatoxin and nitrogen balance in the young calf. | | 1973 | 4745450 |
| optimal freezing conditions for cerebral metabolites in rats. | | 1973 | 4761701 |
| histochemical demonstration of rat liver glycogen phosphorylase activity with iron (fe++). | | 1973 | 4768895 |
| [the effect of insulin hypoglycemia on motility of the jejunum and ileum in dogs]. | | 1973 | 4769280 |
| intracellular distribution of co-lipase and folate conjugase in the rat pancreas. | | 1973 | 4771111 |
| volume distribution and ultrastructure of platelets in acute hog cholera. | | 1973 | 4773376 |
| [the effect of cocarboxylase on lymphocyte metabolism in newborn rats with experimental asphyxia]. | | 1973 | 4804642 |
| anion and cation requirements for glucose and methionine accumulation by hymenolepis diminuta (cestoda). | | 1974 | 4815941 |
| effects of drugs on 47ca2+ movements in depolarized longitudinal smooth muscle. | | 1974 | 4824889 |
| effect of pge2 on the turnover of calcium in rat uterus. | | 1974 | 4833687 |
| the amino acid sequence of putidaredoxin, an iron-sulfur protein from pseudomonas putida. | | 1974 | 4833743 |
| morganella morganii antigenically related to escherichia coli 0111: k58(b4). | | 1967 | 4860403 |
| effect of previous injection of homologous embryonic tissue on the growth of certain transplantable mouse tumours. | | 1967 | 4862516 |
| trachoma among the navajo indians. | | 1970 | 4904035 |
| [aspects of induced resistance to gentamicin in proteus morganii and escherichia coli]. | | 1968 | 4906319 |
| [studies on the freezing and drying of biological specimens by electron microscopy]. | | 1970 | 4919840 |
| [studies on the functional and morphological changes after unilateral and bilateral lung reimplantation with special reference to the neural regulation of respiration without the hering-breuer reflex]. | | 1969 | 4923195 |
| the effect of antigen pretreatment on canine renal allograft survival. | | 1971 | 4934110 |
| [teratology and breeding hygiene]. | | 1971 | 4936164 |
| computer stimulation of a living cell. i. | | 1971 | 4938130 |
| the use of zonal centrifugation in the preparation of glomeruli and tubular fragments from rat kidney. | | 1971 | 4940378 |
| biosynthesis of pregnenolone. | | 1971 | 4946132 |
| the genetic effects of ionizing radiations. | | 1971 | 4947106 |
| gastrointestinal parasites of farm animals in eastern nigeria. | | 1966 | 4961677 |
| [partial sterility of duck embryos developed from the anterior and posterior segments of the blastoderm isolated in the non-incubated stage]. | | 1967 | 4963648 |
| release of kinins from fresh plasma under varying experimental conditions. | | 1967 | 4964067 |
| bacteriocin (hemolysin) of streptococcus zymogenes. | the sensitivity of streptococcus faecalis (attc 8043) to s. zymogenes x-14 bacteriocin depends greatly on its physiological age. sensitivity decreases from the mid-log phase on and is completely lost in the stationary phase. the sensitivity of erythrocytes to the hemolytic capacity of the bacteriocin showed considerable species variation. the order of increasing sensitivity was goose < sheep < dog < horse < human < rabbit. however, when red cell stromata were used as inhibitors of hemolysis in a ... | 1968 | 4972910 |
| [evidence for mesosomic formations in the vegetative cells of chondromyces apiculatus thaxter]. | | 1968 | 4972983 |
| cerebral angiography after arteriolar embolization. angiography of acute phase in the monkey. | | 1969 | 4974807 |
| [supplement to the study of the mechanism of electrocardiographic alterations in meningeal hemorrhage (experimental study)]. | | 1969 | 4975492 |
| chromatography and activity of thiol-subtilisin. | | 1969 | 4975909 |
| collagen implants in the vitreous. | | 1969 | 4982226 |
| c-type virus and lymphocytic nuclear projections in bovine lymphosarcoma. | | 1970 | 4986933 |
| localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. | | 1970 | 4987453 |
| [difference in the branching of the femoral artery in man and in macaques]. | | 1970 | 4990431 |
| [differentiation of streptococcus faecalis andrewes a. horder from str. faecium orla-jensen by physiological characteristics]. | | 1970 | 4996135 |
| incidence of antibodies to double-stranded rna in systemic lupus erythematosus and related diseases. | | 1971 | 4998028 |
| "carpal canal" syndrome in horses. | | 1972 | 5014892 |
| the fluorescence from the tryptophans of rhodopsin. | | 1972 | 5034101 |
| [mechanism of action of erythropoietin on energy metabolism of bone marrow]. | | 1972 | 5050574 |
| a simple and rapid method for quantitative determination of protein in urine. | | 1972 | 5061737 |
| the pattern of methylation of rna in peripheral nerve of the chick during development. | | 1972 | 5072384 |
| enterectomy and correction of an abnormal fistula in the horse. | | 1972 | 5073136 |
| intermediate reactions in the binding of aminoacyl-transfer ribonucleic acid to rat liver ribosomes. the interaction of cholesteryl 14-methylhexadecanoate. | 1. transferase i from rat liver extracted with iso-octane binds significantly less aminoacyl-trna than the non-extracted enzyme. the original activity can be fully restored by the addition of cholesteryl 14-methylhexadecanoate. the binding capacity for gtp is not affected by the extraction. 2. in the presence of extracted transferase i the binding of aminoacyl-trna to ribosomes is decreased to 11-26% and the simultaneous binding of gtp to 32-43%. cholesteryl 14-methylhexadecanoate induces a full ... | 1972 | 5073734 |
| enzymatic inactivation of gentamycin by extracts from antibiotic resistant proteus morganii strains. | | 1972 | 5073886 |
| cellular immunity: alterations of macrophage functions by mediators from lymphocytes. | | 1972 | 5077115 |
| a receptor for proteus morganii bacteriocin 336. | | 1971 | 5089336 |
| [stall-associated hoof diseases]. | | 1971 | 5109010 |
| [experimental study on allergic otitis media. 2. allergenic effect of bacterial component of proteus morgani]. | | 1967 | 5183820 |
| synergistic antibacterial activity of ampicillin-cloxacillin mixtures against proteus morganii. | synergistic antibacterial effects of mixtures of ampicillin and cloxacillin and induced penicillinases were investigated in 48 strains of proteus. the serial tube dilution method was used to determine the minimal inhibitory concentration of ampicillin, cloxacillin, and 2:1 and 1:1 mixtures of ampicillin and cloxacillin. production of penicillinases was determined by the cellulose acetate membrane method, with ampicillin, cloxacillin, mixtures of ampicillin and cloxacillin, penicillin g, and ceph ... | 1968 | 5188339 |
| properties of a proteus morganii bacteriocin. | | 1968 | 5729611 |
| [acute hemolytic anemia in the course of spesis caused by proteus morganii in a subject with erythrocytic glucose-6-phosphate dehydrogenase deficiency]. | | 1968 | 5755413 |
| isolation of proteus morganii from an atypical form of fatal gastro-enteritis in cattle. | | 1966 | 5950631 |
| transduction in proteus morganii. | | 1966 | 5962096 |
| properties of providence and proteus morganii transducing phages. | | 1966 | 5969499 |
| five new serotypes of morganella morganii. | | 1967 | 6048149 |
| antigenic relationships between morganella morganii and different genera of enterobacteriaceae. | | 1967 | 6048150 |
| [method for rapid identification of proteus morganii]. | | 1984 | 6084743 |
| the in vitro antimicrobial activity of desacetylcefotaxime compared to other related beta-lactams. | like all other cephalosporins that contain an acetyl side chain in the 3' position, cefotaxime (ctx) is partially desacetylated in vivo. desacetylcefotaxime (des-ctx) possesses a broad antimicrobial spectrum and high beta-lactamase stability. with the exception of pseudomonas aeruginosa, morganella morganii, bacteroides fragilis, and staphylococcus aureus, most strains of other species tested usually had mean mics of des-ctx lower than 1 microgram/ml. its activity is generally lower than that of ... | 1984 | 6086214 |
| efficacy of ceftizoxime administered twice daily in hospitalized patients with respiratory tract infections. | the efficacy and safety of ceftizoxime administered twice daily were evaluated in 215 hospitalized patients with documented lower respiratory tract infections. the majority of patients received 1 to 2 gm of ceftizoxime intramuscularly or intravenously every 12 hours; the mean dosage was 2 gm/day, and the mean duration of therapy was 8.9 days. clinical cure was achieved in 204 (95%) of the 215 patients with lower respiratory tract infection. one hundred and thirty-eight patients were both clinica ... | 1984 | 6097357 |
| conserved genes in enteric bacteria are not identical. | in addition to ribosomal rna genes, a relatively small number of genes are highly conserved between escherichia coli and salmonella typhimurium on the one hand, and either serratia marcescens or proteus morganii on the other hand. the conserved non-rrna genes are not the same in s. marcescens and p. morganii. different genetic segments have maintained nucleotide sequence similarity to parts of the e. coli and s. typhimurium genomes in the course of the evolution of s. marcescens and p. morganii. | 1980 | 6162076 |
| interaction of mezlocillin and cefoxitin against proteus morganii in the granuloma pouch model. | the interaction of cefoxitin and mezlocillin was studied in rats using the granuloma pouch technique. proteus morganii strains against which cefoxitin and penicillins exhibited antagonistic antibacterial activity were selected for infection of the pouches. animals were treated with cefoxitin and/or mezlocillin, and bacterial counts, drug levels and beta-lactamase production in the pouch exudate monitored. a significant decrease in bacterial counts was seen after administration of mezlocillin and ... | 1982 | 6217067 |
| in-vitro synergism between mezlocillin and isoxazolyl penicillins against beta-lactamase-producing gram-negative organisms. | forty beta-lactamase producing gram-negative organisms were tested with mezlocillin plus an isoxazolyl penicillin for synergy. with standard chequerboard techniques, the combination showed enhanced activity, when compared to either drug alone, against 30 strains. eighteen of these 30 strains showed synergism at concentrations of mezlocillin and isoxazolyl penicillins which were attainable in the serum (7 strains of morganella morganii, 8 strains of eschericia coli and 3 strains of serratia marce ... | 1983 | 6222024 |
| [toxic properties of proteus morganii]. | | 1983 | 6222795 |
| in vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. | enoxacin is a new quinolone carboxylic acid compound. its activity against 740 bacterial isolates was determined. it inhibited 90% escherichia coli, klebsiella sp., aeromonas sp., enterobacter spp., serratia spp., proteus mirabilis, and morganella morganii at less than or equal to 0.8 micrograms/ml. the majority of pseudomonas aeruginosa was inhibited by less than or equal to 3.1 micrograms/ml. haemophilus spp. and neisseria spp. were inhibited by less than 0.1 micrograms/ml. although most staph ... | 1983 | 6229216 |
| [use of azlocillin in the treatment of pseudomonas bronchopulmonary infections]. | eleven patients with severe bronchopulmonary infection due to pseudomonas were treated with azlocillin in doses of 250 mg/kg/day. severe preexisting respiratory diseases, such as bronchopulmonary carcinoma, bronchiectasis or respiratory insufficiency were present in all cases. all patients had been unsuccessfully treated with various antibiotics before they received azlocillin. the pathogenicity of the isolates was assessed by germ counts in sputum. comparative in vitro sensitivities to carbenic ... | 1984 | 6231607 |
| [toxic activity of the cellular structures of proteus morganii]. | | 1984 | 6237742 |
| the occurrence of the trehalose fermenting, tetracycline and polymyxin resistant phenotype among the enterobacteriaceae. | in proteus morganii, p. mirabilis, and providencia stuartii the ability to ferment trehalose and resistance to tetracycline were associated in 90%-97% of the strains. the same was true of at least 78% of the strains of serratia marcescens. proteus vulgaris showed a more quantitative association of the two traits. as the characters occur independently in 3-10% of the strains, the association is considered to be due to simultaneous selection in some natural niche. the trehalose fermenting, tetracy ... | 1980 | 6251697 |
| effect of combination of cefsulodin and mecillinam. | the effect of cefsulodin in combination with mecillinam was examined against a wide range of bacterial species. the antibacterial spectrum was widened by the combination of cefsulodin and mecillinam in the ratio of 5:1 and 10:1. in overall observations, in the in vitro test, a synergistic effect against clinical isolates was found on klebsiella pneumoniae, citrobacter freundii, enterobacter cloacae, serratia marcescens, proteus mirabilis and proteus vulgaris, and an additive effect was found on ... | 1981 | 6268593 |
| [antibacterial activities of cefotiam against various pathogens isolated from clinical materials (author's transl)]. | bacteriological evaluation was made on cefotiam (ctm), a new broad-spectrum cephalosporin antibiotic, and the following results wer obtained. 1) ctm has shown very potent antibacterial activities against staphylococcus aureus, escherichia coli, edwardsiella tarda, citrobacter intermedius, salmonella, klebsiella, proteus mirabilis, proteus rettgeri, proteus inconstans, yersinia enterocolitica, aeromonas hydrophila, plesiomonas shigelloides and pseudomonas putrefaciens. 2) streptococcus faecalis, ... | 1982 | 6285018 |
| [laboratory and clinical investigations of cefotiam in surgical biliary tract infections]. | laboratory and clinical comparative investigations with cefotiam (ctm) and cefazolin (cez) were performed to confirm efficacy and safety in surgical, biliary tract infections. the following results were obtained. 1) the mics of ctm against organisms, 20 strains, which were isolated from bile of patients with cholecystitis, were studied, especially those of ctm against e. coli and klebsiella were 0.2 - greater than or equal to 100 micrograms/ml and 0.1--12.5 micrograms/ml, respectively, considera ... | 1982 | 6290699 |
| synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam. | the beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-lactamase-containing escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-lactamase-containing enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant klebsiella, citrobacter, serratia, and salmone ... | 1982 | 6291454 |
| cefotaxime: a review of in vitro antimicrobial properties and spectrum of activity. | cefotaxime has remarkable potency against all enterobacteriaceae, including enterobacter species, citrobacter freundii, serratia marcescens, and morganella morganii, proteus vulgaris, and providencia species--all of which are resistant to earlier cephalosporins. cefotaxime generally inhibits greater than 90% of enteric bacilli at concentrations of less than or equal to 0.5 microgram/ml; in one study it inhibited greater than 98% of isolates at less than or equal to 8 micrograms/ml. for staphyloc ... | 1982 | 6294779 |
| antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: evidence of synergy. | the level of antimicrobial activity of 3-desacetylcefotaxime was found to be approximately eightfold lower than that of cefotaxime. variation in the inhibitory effects of desacetylcefotaxime was species dependent. desacetylcefotaxime was 1-2 log2 dilutions more active than cefotaxime against pseudomonas acidovorans and pseudomonas cepacia. desacetylcefotaxime and cefotaxime were bactericidal, and their minimal inhibitory concentrations were influenced only slightly by increases in the inoculum c ... | 1982 | 6294785 |
| cefoxitin, n-formimidoyl thienamycin, clavulanic acid, and penicillanic acid sulfone as suicide inhibitors for different types of beta-lactamases produced by gram-negative bacteria. | cefoxitin, n-formimidoyl thienamycin (mk0787), clavulanic acid, and penicillanic acid sulfone (cp45,899) were studied to determine their potency as suicide inhibitors of three very different kinds of beta-lactamases produced by gram-negative bacteria: type ib penicillinase (tem-2 type), a typical cephalosporinase (the enzyme of proteus morganii), and a cephalosporinase with broad substrate specificity (the enzyme of proteus vulgaris). all these beta-lactams were confirmed to be quite stable to t ... | 1982 | 6298169 |
| molecular cloning of proteus morganii phenylalanine deaminase gene in escherichia coli. | the gene for phenylalanine deaminase (pad) of proteus morganii strain 2815 has been isolated on a 6.3-kb hindiii restriction fragment and cloned within rp4-prime plasmids, pyb2321 and pyb2322, in both orientations. expression of the cloned gene in escherichia coli strains was comparable to that in p. morganii 2815. the hybrid plasmids mobilized the 2815 chromosome with trajectories in reverse directions from an origin between ser-2 and ade-1, suggesting the map location of the pad gene. | 1983 | 6301948 |
| comparison of the lipoprotein gene among the enterobacteriaceae. dna sequence of morganella morganii lipoprotein gene and its expression in escherichia coli. | a dna sequence of 532 base pairs encompassing the entire morganella morganii lipoprotein gene (lpp) was determined. sequence comparisons of the m. morganii lpp gene with the lpp genes from escherichia coli, serratia marcescens, and erwinia amylovora reveal that the m. morganii lpp gene is more distantly related to the e. coli lpp gene than any of the other lpp genes examined. between the e. coli and m. morganii lpp genes, the following homologies were found: 44% in the promoter region (bases, -4 ... | 1983 | 6305973 |
| [in vitro bacteriostatic activity of cefmenoxime (sce 1365), cefotaxime and moxalactam]. | the in vitro activity of cefmenoxime (sce 1365), a new cephalosporin derivate was compared with two other "third generation" cephalosporins: cefotaxime and moxalactam. cefmenoxime as cefotaxime and moxalactam were very active against 305 cephalosporinase-producing and cephalosporinase-non-producing enterobacteriaceae. cefmenoxime was the most active against serratia marcescens, citrobacter freundii, morganella morganii, salmonella, shigella and yersinia enterocolitica with a mean mic at least tw ... | 1983 | 6312395 |
| [hplc study of the inhibition of enterobacterial cephalosporinases by cefmenoxime]. | high performance liquid chromatography (hplc) has shown that cefmenoxime and cefotaxime are stable to the cephalosporinase of enterobacter cloacae p99 , morganella morganii gn 1510 and serratia liquefaciens 132. they are significantly resistant to hydrolysis by 100 cephalosporinase units (cephalosporinase production of 10(12) bacterial). cefmenoxime and cefotaxime are also inhibitors of cephalosporinase at the concentration of 5.10-10 micrograms per 10-10 unit of enzyme. | 1984 | 6330649 |
| susceptibility of gram-negative bacteria to polymyxin b nonapeptide. | subinhibitory concentrations of polymyxin b nonapeptide sensitized all 21 polymyxin-susceptible gram-negative bacterial strains studied to hydrophobic antibiotics such as fusidic acid, novobiocin, and erythromycin. the susceptibility increases were usually 30- to 300-fold. the strains included representatives of escherichia coli with different o- and k-antigens, klebsiella pneumoniae, klebsiella oxytoca, enterobacter cloacae, enterobacter agglomerans, salmonella typhimurium, acinetobacter calcoa ... | 1984 | 6331296 |
| synergism of ps-5 with penicillins and cephalosporins in antimicrobial activity against beta-lactam-resistant gram-negative microorganisms. | the in vitro synergism of ps-5 combined with various penicillins and cephalosporins in antimicrobial activity was examined in detail against beta-lactam-resistant gram-negative bacteria. ps-5 showed a highly significant synergism in antimicrobial action against escherichia coli rgn238 in combination with penicillins; and against proteus vulgaris gn76 and serratia marcescens t55 in combination with cephalosporins. it was moderately synergistic against citrobacter freundii gn346, enterobacter cloa ... | 1984 | 6334679 |
| proteus morgani is less frequently associated with urinary tract infections than proteus mirabilis--an explanation. | the metabolic activities of faecal and urinary strains of proteus morgani and p. mirabilis were compared. regardless of origin, the generation time of p. morgani strains in urine was approximately twice as long as that of the p. mirabilis strains. urease synthesis was constitutive in p. morgani strains but required induction with urea in the p. mirabilis strains. in the presence of urea, the p. mirabilis strains liberated ammonia more rapidly and produced alkaline conditions more quickly than p. ... | 1983 | 6348289 |
| serious nosocomial infection caused by morganella morganii and proteus mirabilis in a cardiac surgery unit. | in july and august 1981, five patients in the cardiac surgery unit of the bristol royal infirmary developed septicemia caused by morganella morganii, proteus mirabilis, or both of these species. three of the patients had serious wound infections, and three of the patients died. typing of the m. morganii isolates by o-serotyping and of the p. mirabilis isolates by o-serotyping, proticine production and sensitivity, and the dienes reaction confirmed cross infection by both species. although m. mor ... | 1983 | 6350354 |
| induction of cephalosporinase production by various penicillins in enterobacteriaceae. | the inducer activity of seven penicillins for cephalosporinase (csase) production and their antibacterial activity against csase-producing strains were studied using clinical isolates of proteus morganii, p. rettgeri, p. vulgaris, enterobacter cloacae, and serratia marcescens. piperacillin, apalcillin, and methicillin showed rather low inducer activity for csase production in all strains tested. on the other hand, ampicillin, carbenicillin, and sulbenicillin showed high inducer activity for csas ... | 1983 | 6358172 |
| quaternary heterocyclylamino beta-lactams. iii. the mode of action of l-640,876 and the effect of nacl on membrane permeability and binding. | l-640,876, 7-beta(1-benzylpyridinium-4-yl)amino-3-[( (1-methyl-1 h-tetrazol-5-yl)thio]methyl)-ceph-3-em-4-carboxylate, is a potent representative of a new family of beta-lactam antibiotics which are similar in some respects to mecillinam. when l-640,876 and mecillinam were compared for effects on growth and morphology of escherichia coli, it was observed that both drugs caused the formation of lemon-shaped cells during the first 30 minutes of exposure and during this period the culture turbidity ... | 1983 | 6381447 |
| n-nitrosamine formation by intestinal bacteria. | n-nitrosamine formation by various intestinal bacteria was investigated. n-nitroso-dimethylamine (ndma) formation by viable resting cells of escherichia coli a10 was proportional to the incubation time and the enzyme concentration, while boiled cells were incapable of nitrosation. the enzyme was optimal at ph 7.5 and showed about the same specificities for dimethylamine, diethylamine, dibutylamine, di-isobutylamine, piperidine and pyrrolidine, but high specificity for morpholine. the intestinal ... | 1984 | 6398295 |
| therapeutic efficacy of a new cephamycin, mt-141, in compromised mice. | the antibacterial activity of mt-141 against escherichia coli and proteus morganii in compromised mice was investigated and compared with that of latamoxef, cefmetazole and cefoxitin. the bactericidal activity of mt-141 in short-term contact with e. coli and p. morganii was markedly enhanced when combined with mouse serum, and the activity of mt-141 was greater than the activities of the three reference drugs. the antibacterial activities of mt-141 in the liver, spleen and kidney of neutropenic ... | 1984 | 6441793 |
| in vitro antibacterial activity of moxalactam, a new broad-spectrum semisynthetic antibiotic. | the antibacterial activity of moxalactam was studied in vitro against 229 clinical isolates of gram-positive and gram-negative aerobic microorganisms using the agar dilution technique. mueller-hinton agar was used as growth medium. the results were compared to those obtained with cefamandole. all isolates of staphylococcus aureus and streptococcus pneumoniae were inhibited by moxalactam at a concentration of 8 microgram/ml or less. the concentrations of cefamandole with which the same effect was ... | 1980 | 6447672 |
| [fosfomycin, a new antibiotic: in vitro activity compared with mezlocillin, cefuroxime and gentamicin]. | in vitro investigations with fosfomycin, mezlocillin, cefuroxime, and gentamicin against staphylococci, enterobacteriaceae an pseudomonadaceae were carried out by agar dilution method on mueller-hinton agar. the fosfomycin breakpoint for the low dosage of 2-3 times 3 g per infusion daily was defined with 16 micro g/ml and for the high dosage of 2-3 times 5 g fosfomycin per infusion with 64 micro g/ml. at a concentration of 16 micro g/l fosfomycin more than 90% of the cultures of staph. aureus (p ... | 1980 | 6453080 |
| worldwide clinical experience with cefoperazone. | the safety and clinical efficacy of cefoperazone 1 to 2g 12-hourly was evaluated in clinical trials conducted in the united states, europe, south and latin america, and japan. 1046 patients were treated in 4 comparative and 9 non-comparative studies. an overall satisfactory clinical response for cefoperazone therapy was achieved in 540 (88%) of the 615 evaluable patients. cefoperazone was effective in 92% of lower respiratory tract infections, 81% of urinary tract infections, 98% of gynaecologic ... | 1981 | 6456884 |
| [clinical evaluation of 6059-s therapy in children (author's transl)]. | a new semisynthetic 1-oxa-beta-lactam derivative, 6059-s, was evaluated for its safety and efficacy in children. twenty-five patients were treated with 10 to 274 mg/kg per day of 6059-s by intravenous administrations. the diagnosis of the patients were acute pharyngitis (2), acute bronchitis (2), pneumonia (4), pertussis (4), acute enterocolitis (2), recurrent urinary tract infection (2), suspected septicemia (3), and acute purulent meningitis (1); and the remaining 5 patients were considered to ... | 1981 | 6457168 |
| comparison of mezlocillin and carbenicillin as therapy for various infectious diseases. | the efficacy and safety of mezlocillin, a new broad-spectrum semisynthetic penicillin, were compared with those of carbenicillin in a nonblind, controlled clinical study in 89 adult patients. the infections treated were primarily those of the urinary tract, skin, and gastrointestinal or hepatobiliary tract. escherichia coli, proteus mirabilis, proteus morganii, and pseudomonas aeruginosa were the causative organisms isolated most frequently. a complete resolution of signs and symptoms was achiev ... | 1981 | 6460558 |
| comparative in-vitro activity of quinolone carboxylic acids against proteeae. | the in-vitro susceptibilities of 198 isolates of precisely identified proteeae species to six quinolone antimicrobials were determined. significant differences in susceptibility patterns among various proteeae to the quinolones examined were demonstrated. although providencia stuartii was found to be the most resistant to quinolones including the very active agent ciprofloxacin, fully speciated prov. rettgeri were also markedly resistant as well. in contrast prov. alcalifaciens was extremely sen ... | 1984 | 6511707 |
| morganella morganii: epidemiology of bacteremic disease. | a retrospective review of microbiology records revealed 19 documented episodes of m. morganii bacteremia in 18 patients at a veterans administration hospital during a 5.5 year period. thirteen of 19 bacteremias were related to nosocomial infections; 11 of the 13 nosocomial bacteremias occurred in surgical patients. nine of the 13 patients with nosocomial bacteremia had received recent therapy with a beta-lactam antibiotic. the most common source of bacteremia was a postoperative wound infection ... | 1984 | 6561180 |
| treatment of experimental chronic osteomyelitis caused by morganella morganii with mezlocillin and cloxacillin. | mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to morganella morganii. this combination showed in vitro synergy as measured by the checkerboard technique. a marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting strain of m. morganii. in therapeutic trials, mezlocillin administered for 28 days was totally ineffective. the combination of mezlocillin and cloxacillin (at 800 and 400 mg/kg, respec ... | 1984 | 6563980 |
| effect of 7 alpha substitution of cephems on their beta-lactamase stability and affinity for penicillin-binding proteins in morganella morganii. | cephamycins, which have a methoxy group at the 7 alpha position of their cephalosporin nuclei, were highly stable against hydrolysis by a beta-lactamase purified from a clinical isolate of morganella morganii, whereas their 7 alpha-h analogs were rapidly hydrolyzed by the enzyme. the high stability of the cephamycins was not due to their low affinity for the enzyme, since the cephamycins strongly inhibited the enzyme in a competitive manner. in cases in which the 7 alpha-methoxy group was substi ... | 1983 | 6602587 |