| helicobacter pylori and chronic active inflammation of the duodenum and stomach in duodenal ulcer patients treated with ranitidine, misoprostol, or an acid-neutralizing agent. | biopsy specimens from the stomach and duodenum of 45 duodenal ulcer patients treated with ranitidine, misoprostol, or an antacid were examined. during 4 weeks of treatment the duodenal ulcer healed in 31 patients. the treatment regimens showed no significant effect on the amount of helicobacter-like structures (hls) or the presence of active inflammation, either in the stomach or in the duodenum. all patients had chronic active antral gastritis before and after treatment. hls were found histolog ... | 1991 | 1908115 |
| [helicobacter pylori and duodenal ulcer treated with omeprazole]. | | 1991 | 1910925 |
| helicobacter pylori: its epidemiology and its role in duodenal ulcer disease. | | 1991 | 1912414 |
| helicobacter pylori: causal agent in peptic ulcer. microbiological aspects. | | 1991 | 1912415 |
| virulence and pathogenicity of helicobacter pylori. | h. pylori is a highly virulent organism as evidenced by its low infective dose and widespread high prevalence in human populations. its virulence is achieved through its ability to survive in a moist environment and its massive urease production which allows it to survive in the acidic gastric juice long enough to colonize the gastric mucus. gastric colonization is facilitated by cell wall associated lectins which permit the bacterium to bind to gastric mucus and the gastric epithelial cell. onc ... | 1991 | 1912416 |
| helicobacter pylori and peptic ulceration: histopathological aspects. | | 1991 | 1912417 |
| helicobacter pylori therapy: effect on peptic ulcer disease. | | 1991 | 1912418 |
| helicobacter pylori: causal agent in peptic ulcer disease? conclusion. | | 1991 | 1912419 |
| medical treatment of duodenal ulcer: acid inhibition or helicobacter pylori eradication? | to ascertain whether acid inhibition or helicobacter pylori (hp) colonization is the decisive factor in the healing of duodenal ulcer, we treated 54 patients with famotidine and carried out long-term follow-up. helicobacter pylori colonization was found in 70.4% of patients before treatment. there were no differences in the pre-treatment characteristics between patients with hp positive or hp negative ulcers. the 4-week and 8-week healing rates after famotidine treatment were 72.5% and 82.4% res ... | 1991 | 1912420 |
| helicobacter pylori and duodenal ulcer. | | 1991 | 1912428 |
| the sydney system: epidemiology and natural history of chronic gastritis. | chronic gastritis is a common disease which forms an important background to the pathogenesis of several gastric diseases. in most instances, gastritis seems to be a bacterial (microbial) disease. it begins as long-lasting, chronic inflammatory reaction directed against helicobacter pylori (hp), or occasionally against other spiral bacteria, which colonize in the space between the surface epithelium and the mucous layer. gastritis may, irrespectively of the hp-related or hp-independent origin, p ... | 1991 | 1912435 |
| [duodenal ulcer disease: helicobacter pylori and hyperchlorhydria]. | basal and pentagastrin-stimulated gastric acid secretion and basal serum gastrin level were investigated in 55 active duodenal ulcer patients with antral colonization with helicobacter pylori (hp) and 17 patients without. our study shows that basal (bao) and pentagastrin-stimulated gastric acid secretion (mao and pao) were significantly higher in hp positive than in hp negative patients with duodenal ulcer disease. there were also a tendency to increase in basal serum gastrin concentration in hp ... | 1991 | 1914666 |
| sensitivity of helicobacter pylori to different bile salts. | the sensitivity of helicobacter pylori to different unconjugated or conjugated bile acids both on bhi blood agar and in bhi broth supplemented with starch, horse serum or egg yolk was studied. bile salts were more toxic in the medium containing starch than in the media containing horse serum or egg yolk, and unconjugated bile salts were more toxic than the conjugated salts. deoxycholic acid was the most toxic of the bile acids studied. ox bile was bacteriostatic at the 2% level. bile salts 3 mix ... | 1991 | 1915389 |
| helicobacter pylori density on antral mucosa of patients with and without duodenal ulceration. | | 1991 | 1916140 |
| [gastritis caused by spiral bacteria other than helicobacter pylori: clinical, histological and ultrastructural study]. | | 1991 | 1916148 |
| detection of helicobacter pylori infection of the gastric mucosa by measurement of gastric aspirate ammonium and urea concentrations. | helicobacter pylori possesses unusually high urease activity that lowers the urea concentration and raises the ammonium concentration of the gastric juice in infected people. the value of measuring urea and ammonium concentrations in gastric juice obtained during upper gastrointestinal endoscopy as a means of diagnosing the presence and eradication of the infection was assessed. twenty four subjects with the infection and 14 in whom it had been eradicated were examined. their h pylori status was ... | 1991 | 1916500 |
| [effect of as-2646, a novel antiulcer agent on gastric mucosal defensive factors in rats]. | the effects of as-2646 on the acute gastric mucosal lesions induced by various noxious agents and the gastric mucosal defensive factors were studied in rats, and the following results were obtained: 1) as-2646 (5-100 mg/kg, p.o.) dose-dependently inhibited the formation of the mucosal lesions induced by ethanol, ethanol-hcl, taurocholate-hcl and serotonin, and its anti-lesion spectrum was the widest among the compounds (cimetidine, pirenzepine, sulpiride and prostaglandin e1) examined here. 2) a ... | 1991 | 1916545 |
| epithelial damage by helicobacter pylori in gastric ulcers. | on review of 136 consecutive biopsies of benign gastric ulcer, helicobacter pylori was detected in 78 cases (57.3%). the gastric epithelium colonized by helicobacter pylori showed a characteristic constellation of changes, including loss of apical mucous portion of individual cells, drop-out of epithelial cells, epithelial pits, erosions and cellular tufts, indicative of cellular injury and regeneration. among the 58 helicobacter-negative cases, similar changes were not observed in the ulcer edg ... | 1991 | 1916686 |
| immune responses to helicobacter pylori in children with recurrent abdominal pain. | the systemic immune response to helicobacter pylori was examined in 69 children with recurrent abdominal pain and upper gastrointestinal symptoms. twenty one (30%) children were histologically positive for h pylori. eighteen of the 21 positive subjects and two h pylori negative subjects (one with normal mucosa, one with lymphocytic gastritis) were positive for h pylori igg antibodies by enzyme linked immunosorbent assay (elisa) (86% sensitivity, 98% specificity). in children with h pylori associ ... | 1991 | 1918408 |
| colonization of helicobacter pylori in the gastric mucosa of mongolian gerbils. | helicobacter pylori was orally inoculated into mongolian gerbils. the organisms were able to colonize in the gastro-mucosal layer of the gerbils, especially in those gerbils which had mucosal lesions caused by indomethacin treatment. the pathological changes developed by h. pylori infection were restricted to the stomachs, and only slightly inflammatory cells were observed. | 1991 | 1921762 |
| [chronic gastritis and the presence of helicobacter pylori in patients with non-ulcerative dyspepsia]. | after definition in the group of the non ulcer dyspepsia (nud) can be counted all those patients at whom beside the dyspeptical complaints, the radiological and endoscopical examinations didn't show ulcerative changes. the authors made biopsy 550 times on the occasion of 1390 gastroscopical examination (39.5% of the cases). the histological examination showed chronic gastritis in 372 cases (26.7% of all the examinations, 67.6% of the histological examinations). at this group of patients the dysp ... | 1991 | 1923463 |
| immunocytochemical identification of helicobacter pylori in formalin-fixed gastric biopsies. | h&e and special histochemical stains are used by most laboratories to identify helicobacter pylori (h. pylori) in gastric biopsy specimens. however, background staining can complicate recognition of h. pylori and small numbers of organisms may be overlooked. additionally, histochemical stains do not distinguish h. pylori from other spiral organisms. we investigated two commercially available monoclonal antibodies, one directed against campylobacter coli and c. jejuni (mab002) and the other again ... | 1991 | 1924280 |
| gastritis and its relation to gastric carcinogenesis. | there have been rapid changes in understanding of chronic gastritis recently, fueled largely by the recognition of gastric infection by helicobacter pylori. this report reviews the newer classifications of chronic gastritis, and describes the characteristics of h pylori-positive and -negative patterns of gastritis. the relevance of h pylori infection to gastric carcinogenesis is also discussed. | 1991 | 1925121 |
| adherence of helicobacter pylori to gastric carcinoma cells: analysis by flow cytometry. | an in vitro assay using immunofluorescence and flow cytometry for quantitative assessment of the adherence of helicobacter pylori to cultured human gastric carcinoma (kato iii) cells was developed. adherence was rapid, saturable, energy dependent, mannose resistant, and significantly inhibited by fetuin, a glycoprotein containing n-acetylneuraminyllactose. pretreatment of kato cells with neuraminidase from clostridium perfringens, however, did not reduce adherence of h. pylori. ultrastructurally ... | 1991 | 1925306 |
| elevation of meal-stimulated gastrin release in subjects with helicobacter pylori infection: reversal by low intragastric ph. | the aim of the present study was to determine whether the association between helicobacter pylori infection and increased concentrations of gastrin in serum is independent of chronic duodenal ulcer disease and whether the mechanism of this association involves a disturbance of feedback inhibition of gastrin release by intragastric acid. of 48 subjects evaluated, 26 (54%) were seropositive for h. pylori by elisa. fasting and peptone meal-stimulated gastrin release at ph 2.5 and ph 5.5 as well as ... | 1991 | 1925307 |
| gastritis induced by helicobacter pylori in gnotobiotic piglets. | helicobacter pylori has recently been recognized as a gastric pathogen in humans. experimental oral inoculation of gnotobiotic piglets with this organism results in gastritis that exhibits many features of the corresponding disease in humans. in piglets the organism is restricted to the gastric microenvironment and persists in that location despite prompt humoral and cellular responses to antigens of h. pylori. the gnotobiotic piglet model is useful for delineation of the role of suspected bacte ... | 1991 | 1925308 |
| production of a cytotoxin by helicobacter pylori. | helicobacter pylori produces a cytotoxin that was initially detected as the ability of broth culture filtrates of this bacterium to induce intracellular vacuolation of cultured cells. fifty-three percent of more than 200 isolates of h. pylori tested produce the cytotoxin, which appears to be unique to h. pylori. results of characterization studies suggest that the cytotoxin is a high-molecular-weight protein. detection of serum antibody to the cytotoxin by neutralization or immunoblotting indica ... | 1991 | 1925309 |
| pharmacology of bismuth-containing compounds. | bismuth compounds have been used for more than two centuries. a review of the modes of action, pharmacokinetics, and toxicity of two commonly used compounds, colloidal bismuth subcitrate and bismuth subsalicylate, is presented. in humans bismuth toxicity is unlikely when therapeutic doses of these compounds are administered for the appropriate duration. the recent use of bismuth compounds to eradicate infection with helicobacter pylori and to prevent travelers' diarrhea has resulted in scientifi ... | 1991 | 1925310 |
| helicobacter pylori in patients with nonulcer dyspepsia. | the relationship between endoscopically diagnosed gastroduodenitis, histologically confirmed gastritis, and symptoms of dyspepsia remains unclear. marked histologically confirmed inflammation of gastric mucosa often occurs in a stomach that appears normal by endoscopy. both histologically confirmed and endoscopically diagnosed gastritis are commonly blamed as causes of nonulcer dyspepsia (nud), although neither disease has been convincingly shown to cause nud. helicobacter pylori infection of ga ... | 1991 | 1925311 |
| diagnosis of gastritis caused by helicobacter pylori in children by means of an elisa. | in this study, the systemic immune response to bacterial cell sonicates of helicobacter pylori was characterized in children with symptomatic gastroduodenal disease. isotype-specific antibodies to h. pylori in samples of serum from 16 children with culture-proven disease caused by h. pylori and from 19 controls with negative cultures were measured by elisa with bacterial cell lysates. the levels in serum of iga antibody to cell sonicates of h. pylori were significantly higher in the patients wit ... | 1991 | 1925312 |
| association of infection due to helicobacter pylori with specific upper gastrointestinal pathology. | the association of infection with helicobacter pylori and antral (type b) gastritis now is clear, and the development of sensitive and specific serologic assays for iga and igg allows for diagnosis of this infection by noninvasive means. with use of these assays, we studied the association of infection with h. pylori and four other upper gastrointestinal inflammatory conditions: barrett's esophagus, pernicious anemia (which accompanies type a gastritis), and duodenal and gastric ulcers. h. pylor ... | 1991 | 1925313 |
| characterization of strains of helicobacter pylori: one-dimensional sds-page as a molecular epidemiologic tool. | one-dimensional linear sodium dodecyl sulfate-polyacrylamide gel electrophoresis of total proteins, coupled with a computerized numerical analysis, was used to distinguish among strains of helicobacter pylori. one hundred seventy-five clinical strains and five reference strains of h. pylori from humans, four isolates of helicobacter mustelae from ferrets, and three isolates of h. pylori-like organisms (hplos) from miniature swine were examined. intraspecies and interspecies comparisons were made ... | 1991 | 1925314 |
| gastritis associated with infection by helicobacter pylori: comparative pathology in humans and swine. | infection of humans with helicobacter pylori elicits a multifocal, active, chronic inflammatory response and moderate to severe atrophy of the gastric mucosa. currently, piglets are the only reported animal model of h. pylori infection. our objective was to compare the inflammatory response induced in humans with that induced in piglets by h. pylori infection. samples of gastric mucosa were obtained from h. pylori-infected and uninfected piglets and humans. the composition of the inflammatory ce ... | 1991 | 1925315 |
| synthesis and antimicrobial evaluation of dirithromycin (as-e 136; ly237216), a new macrolide antibiotic derived from erythromycin. | dirithromycin is a 9-n-11-o-oxazine derivative which is formed by condensation of 9(s)-erythromycylamine with 2-(2-methoxyethoxy)acetaldehyde. dirithromycin is hydrolyzed, either under acidic conditions or in vivo, to its major active metabolite, 9(s)-erythromycylamine. the antimicrobial spectrum of dirithromycin is similar to that of erythromycin; both antibiotics are active against gram-positive bacteria, legionella spp., helicobacter pylori, and chlamydia trachomatis. comparable results were ... | 1991 | 1929252 |
| in vitro activity of metronidazole against helicobacter pylori as determined by agar dilution and agar diffusion. | metronidazole activity against 25 clinical isolates of helicobacter pylori was evaluated by agar dilution, epsilometer (e-test; ab biodisk, solna, sweden), and disk diffusion methods after 3 and 5 days of incubation in a microaerophilic atmosphere. agar dilution, performed in duplicate, provided reproducible results with mics for 50% of the isolates of less than or equal to 0.12 microgram/ml after 3 and 5 days of incubation and mics for 90% of the isolates of 2 and 4 micrograms/ml after 3 and 5 ... | 1991 | 1929268 |
| urease production by helicobacter (campylobacter) pylori. | urease activity of 50 helicobacter pylori (h. pylori) strains was assessed employing a photometric assay. urea hydrolysis reached a maximum in the late log-phase and during the plateau phase of bacterial growth. the reaction time of h. pylori urease was significantly shorter than that of other urease producing bacteria (p. mirabilis, p. vulgaris, k. pneumoniae, k. oxytoca). increasing the reaction temperature hardly led to an acceleration of the quick urea hydrolysis of h. pylori, in contrast to ... | 1991 | 1930566 |
| the clinical significance of helicobacter pylori infection in chronic dyspepsia and peptic ulcer disease. | | 1991 | 1930929 |
| gastric helicobacter and upper gastrointestinal symptoms in chronic renal failure. | we studied histologically antral biopsies from 89 consecutive patients with chronic renal failure for helicobacter pylori (previously campylobacter pylori). a dose-response gastric secretion test was also performed. the frequency of helicobacter-positive subjects was low (15/89, 17%), corresponding to figures reported in the literature for young symptomless volunteers. helicobacter-positive patients had significantly more frequently upper gastrointestinal symptoms than helicobacter-negative indi ... | 1991 | 1930936 |
| helicobacter pylori infection in children. | helicobacter pylori was sought prospectively by culture of antral biopsy, histology and serology (igg and iga) in 440 consecutive endoscopies on children to determine the prevalence, clinical presentation and histological features of h. pylori infection in our population. twenty-eight patients had h. pylori (8% overall). the mean age of infected patients was significantly higher than that of non-infected patients (p less than 0.0001). no patient under 5 years of age had h. pylori isolated. overa ... | 1991 | 1932664 |
| helicobacter pylori: an infectious agent in peptic ulcer disease? | | 1991 | 1935723 |
| helicobacter pylori in peptic ulcer disease in kenya. | sixty six patients with dyspeptic symptoms underwent upper gastrointestinal endoscopy and biopsies for helicobacter pylori culture. the number of h. pylori isolated increased with age reaching a peak at 51 to 60 years of age. antral gastritis closely followed by duodenitis accounted for the highest number of h. pylori isolated, (87.5% and 85.7% respectively). in patients with duodenal ulceration only, 57% had h. pylori isolated from their antral biopsies, a result that was just slightly higher t ... | 1991 | 1935724 |
| helicobacter pylori infection and inflammation of the gastric corpus. | | 1991 | 1936821 |
| cytological brushing urea broth test: a highly sensitive and specific test for helicobacter pylori infection. | | 1991 | 1936834 |
| helicobacter pylori and the endoscopist: whether to diagnose. | | 1991 | 1936844 |
| in vitro binding of helicobacter pylori to human gastric mucin. | the in vitro binding of four helicobacter pylori strains to human gastric mucin was studied with an enzyme-linked immunosorbent assay. all four strains were found to bind to purified mucin. neuraminidase treatment and nonspecific oxidation of mucin decreased bacterial adherence to the macromolecule. mucin preparations were also found to inhibit attachment of h. pylori to hep-2 monolayers. | 1991 | 1937781 |
| high-affinity binding of the basement membrane proteins collagen type iv and laminin to the gastric pathogen helicobacter pylori. | the ability of 16 isolates of the human gastroduodenal pathogen helicobacter pylori to bind 125i-radiolabelled tissue proteins was quantitated by liquid-phase assay. while capable of binding generally low levels of collagen types i and ii, vitronectin, and fibronectin (average binding, 8%; highest binding, 23%), the various h. pylori isolates were good binders of the basement membrane proteins collagen type iv and laminin (average binding, 27%; highest binding, 60%). campylobacter species tested ... | 1991 | 1937798 |
| characterization of risk factors for helicobacter pylori infection among men attending a sexually transmitted disease clinic: lack of evidence for sexual transmission. | the mechanism of transmission of helicobacter pylori is unknown. to investigate the role of sexual behavior and demographic factors in the acquisition of h. pylori infection, we evaluated the seroprevalence of antibody to h. pylori in 370 men attending an urban sexually transmitted diseases clinic. sera from the following three groups were analyzed by enzyme-linked immunosorbent assay for h. pylori-specific immunoglobulin g: 78 human immunodeficiency virus (hiv)-seropositive homosexual men, 102 ... | 1991 | 1939565 |
| helicobacter pylori: current perspectives. | within the past decade, there has been an explosion of investigative activity and publications about helicobacter pylori (h. pylori). its role in gastroduodenal disease is becoming greater with definite etiologic association in chronic type b gastritis and a probable role in duodenal ulcer, a probable role in gastric ulcer, and possibly a factor in the development of interstitial type gastric carcinoma. epidemiologic studies have shown h. pylori to be worldwide in distribution with higher preval ... | 1991 | 1940186 |
| gastrin: friend or foe of peptic ulcer? | gastrin represents a direct pathogenic factor only in rare subgroups of ulcer patients, such as in the zollinger-ellison syndrome, the antral g-cell hyperplasia syndrome, and in patients in whom the gastric antrum was erroneously retained following partial gastrectomy. gastrin may play a contributory role in the pathogenesis of uncomplicated peptic ulcer disease, as an exaggerated, but reversible gastrin release appears to be associated with helicobacter pylori colonization. the known trophic ef ... | 1991 | 1940201 |
| childhood protein-losing enteropathy associated with helicobacter pylori infection. | helicobacter pylori was found in a gastric biopsy specimen of a child with protein-losing gastropathy. through erythromycin therapy, clinical and ultrasonographic recovery was associated with the disappearance of the pathogen on repeated biopsy. the association of h. pylori with protein-losing gastropathy has been reported only once in children, to our knowledge. although the causative correlation between the pathogen and the disease has not been proven yet, we suggest that future cases of prote ... | 1991 | 1941415 |
| helicobacter pylori and meckel's diverticulum. | helicobacter pylori is invariably associated with peptic ulceration of the upper gastrointestinal tract. this has led to speculation about its pathogenic role in peptic ulceration. the literature and this present study show that h. pylori is not often associated with peptic ulceration in meckel's diverticulum and hence it is unlikely that it has any significant role in peptic ulceration at this site. | 1991 | 1941736 |
| adherence of helicobacter pylori to human gastric epithelial cells in vitro. | gram-negative spiral organisms, currently referred to as helicobacter pylori, are associated with primary gastritis and duodenal ulceration. the organisms colonise gastric mucus and adhere to epithelial cells of inflamed antra. to further examine the binding of h. pylori to human gastric epithelial cells, we developed and characterised an in-vitro bacterial adherence assay. scanning electronmicroscopy suggested that spiral-shaped bacteria were adherent to the surface of kato-iii cells which were ... | 1991 | 1941988 |
| [status of humoral and cellular immunity in patients with a frequently recurring form of stomach ulcer in the presence of campylobacter pylori]. | the findings at examination of 42 patients with gastric ulcer exhibiting frequent relapses were comparatively assessed in relation to humoral and cellular immunity, presence of mucous microflora and campylobacter pyloridis at the ulcer site. it is shown that in the presence of campylobacter pyloridis specific differences in the immune response were not recorded. the same results were true for mucous microflora. | 1991 | 1942981 |
| [lymph follicle formation and development of intestinal metaplasia in antrum mucosa as a reaction to helicobacter pylori infection]. | we examined 171 patients (76 females and 95 males) with definite type b-gastritis. antrum specimens were taken from all participants for histological examination. we studied the correlations between the formation of lymphoid follicles, the severity of gastritis, the degree of activity of gastritis and the density of helicobacter pylori colonization. in addition we noted the distribution and extent of the intestinal metaplasia. in patients with high degree hp-colonization we found formation of ly ... | 1991 | 1943431 |
| [diagnosis of helicobacter pylori colonization of the gastric mucosa. a prospective comparative study of direct test methods and validation of a new urease test]. | a prospective study including 119 patients submitted for routine endoscopy of the upper gastrointestinal tract was initiated to compare three commercial biopsy urease tests with regard to sensitivity and specificity in detecting helicobacter pylori colonization of the gastric mucosa and their reaction velocity. specific culture, microscopy after staining with methylene-blue, histologic search after modified giemsa staining and the combined results of culture and histology ("true standard") serve ... | 1991 | 1943984 |
| spiral shaped microorganisms in the human duodenal mucosa. | a new spiral shaped microorganism, gastrospirillum hominis, distinct from helicobacter pylori, has recently been described in the gastric mucosa. we report a patient with duodenal erosions who was found to have these organisms in his duodenal mucosa. this bacterium is not necessarily specific to the stomach, and its association with peptic damage needs to be studied further. | 1991 | 1946133 |
| [helicobacter pylori and ulcer disease: significance for diagnosis and therapy]. | helicobacter pylori can cause acute gastritis. it is also associated with chronic gastritis and peptic ulcers. the clinical significance of chronic gastritis is not clear, there are apparently no connections between chronic gastritis and dyspeptic complaints. there is hitherto no reason to treat helicobacter pylori infestation in patients with gastritis or non ulcerating dyspeptic disease. in patients with ulcers several studies have suggested that the rate of recurrence of ulcers is diminished ... | 1991 | 1947543 |
| disappearance of gastritis after eradication of helicobacter pylori. a morphometric study. | helicobacter pylori infection is strongly associated with and is considered a common cause of gastritis. to study the relationship between h. pylori and gastritis, we examined whether a reduction occurs in acute granulocytic and chronic mononuclear inflammation of gastric mucosa after eradication therapy. the examination is based on morphometric counting and on semiquantitative estimation of the density of the inflammatory cells in endoscopic biopsy specimens from antrum and corpus. the series c ... | 1991 | 1947772 |
| use of a mouse model to examine anti-helicobacter pylori agents. | a mouse model of helicobacter infection of the gastric mucosa was evaluated for in vivo screening of new anti-helicobacter pylori therapies. the aim of the study was to test antimicrobial agents with known anti-h. pylori effects in humans to validate that similar results were obtained in the mouse model. specific pathogen-free mice were colonized with h. felis, a cat stomach isolate that has been shown to induce chronic gastritis in gnotobiotic mice. in h. felis-inoculated mice 4 weeks after tre ... | 1991 | 1947781 |
| transmission of helicobacter pylori infection. studies in families of healthy individuals. | helicobacter pylori is accepted as the commonest cause of type-b gastritis. detailed information about the mode of transmission remains scanty. we investigated the frequency of h. pylori infection within families, defined as consisting of a husband and wife with at least one biologic child, all living in the same household. inclusion criteria required that both the parents and the children had been born in the united states, had used no antibiotic or bismuth for the previous 2 months, had no rec ... | 1991 | 1947784 |
| [campylobacter pylori, chronic gastritis and peptic ulcer]. | | 1991 | 1948339 |
| use of selective and non-selective media for the isolation of helicobacter pylori. | antral biopsy specimens from patients having gastroduodenal disorders were cultured in parallel on sheep blood agar (sba) and skirrow's selective medium (ssm) for helicobacter pylori. it was found that the overall isolation rate of the organism was much lower in ssm (54.5%) than on sba (87.9%), a difference which is statistically significant (p less than 0.01). this may be due to the incorporation of polymyxin b in ssm. in absence of a suitable selective medium, blood agar may be used. although ... | 1991 | 1949206 |
| association of helicobacter pylori with gastritis and peptic ulcer diseases. | the occurrence of helicobacter pylori(h.pylori) and its relationship with gastric mucosa were studied by light and electron microscopy and culture of biopsy specimens from gastric mucosa of 160 patients with upper gastrointestinal symptoms. h. pylori were present in 96.6% of patients with active chronic gastritis, 100% of patients with duodenal ulcer and 76.9% of patients with gastric ulcer, while present in only 6.3% of individuals with histologically normal gastric mucosa. the bacteria coloniz ... | 1991 | 1949918 |
| [urea reagent strip for the demonstration of helicobacter pylori]. | | 1991 | 1950014 |
| helicobacter pylori acute gastritis: histological, endoscopical, clinical, and therapeutic features. | we describe seven patients with helicobacter pylori acute gastritis who presented endoscopical picture simulating gastric carcinoma or lymphoma. h. pylori was detected on the antral and on the oxyntic mucosa of all patients. at histological examination, no evidence of malignancy was observed in any of the patients. in the antral mucosa there were edema, hyperemia, and intense polymorphonuclear leukocyte infiltration (neutrophils and some eosinophils) in the lamina propria, mucus layer, and insid ... | 1991 | 1951235 |
| new small animal model for human gastric helicobacter pylori infection: success in both nude and euthymic mice. | in order to develop an experimental rodent model, we administered 2 ml (10(8) organisms/ml) broth culture of any of four human isolated strains of helicobacter pylori by the oral route on a one-time basis to both balb/c nude and balb/c euthymic mice. after 20-wk examination, we have successfully demonstrated that the gastric mucosa of nude mice was continuously, and that of euthymic mice, temporarily (for 2 wk), colonized by orally administered, freshly isolated strains obtained from humans with ... | 1991 | 1951236 |
| lack of activity of omeprazole against helicobacter pylori. | | 1991 | 1951259 |
| syncopes leading to the diagnosis of a helicobacter pylori positive chronic active haemorrhagic gastritis. | a 15-year-old girl was admitted after 1 week of increasing fatigue and pallor. she had no gastro-intestinal complaints. the patient had suffered from four episodes of syncope during the last 3 days prior to admission. besides pallor and a discrete cardiac murmur, the physical examination was normal. a further thorough investigation revealed an iron deficiency anaemia related to a helicobacter pylori positive chronic active haemorrhagic gastritis. treatment consisted of amoxycillin and colloidal ... | 1991 | 1954961 |
| helicobacter pylori in autoimmune gastritis. | | 1991 | 1955148 |
| helicobacter pylori in gastric biopsy specimens. comparison of culture, modified giemsa stain, and immunohistochemistry. a retrospective study. | antral biopsy specimens of 302 different endoscopic investigations of 200 patients with non-ulcer dyspepsia were studied for the presence of helicobacter pylori in order to determine the most sensitive detection method. part of the biopsy was cultured, and part stained using a modification of the giemsa stain, and with an immunoperoxidase technique using a polyclonal rabbit anti-h. pylori antiserum. cross-reactivity of this antiserum with other campylobacter species was minimal. material from 24 ... | 1991 | 1955938 |
| prevalence of helicobacter pylori antibodies in patients on chronic intermittent haemodialysis. | the presence of igg antibodies against helicobacter pylori in haemodialysis patients was studied. furthermore the presence of antibodies in different age cohorts was compared with a population of patients suffering from non-ulcer dyspepsia and healthy blood donors. antibodies were present in 43% of the haemodialysis patients. in the younger age groups the presence was low compared with the control populations; this difference was not present in the older age cohorts. there was an increasing prev ... | 1991 | 1956486 |
| the mode of action of colloidal bismuth subcitrate. | colloidal bismuth subcitrate (cbs) is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. it has little acid-neutralizing effect and does not affect acid secretion. it is uncertain whether cbs affects pepsin secretion, but it does inhibit peptic activity. it causes an increase in mucus glycoprotein secretion and may also bind to the gastric mucus layer to act as a diffusion barrier to hcl. cbs accelerates ulcer healing and causes an accumulation ... | 1991 | 1957120 |
| clinical indications and efficacy of colloidal bismuth subcitrate. | colloidal bismuth subcitrate (cbs; denol) has been studied in clinical trials investigating the treatment of duodenal and gastric ulcer, non-ulcer dyspepsia, duodenitis, non-steroidal anti-inflammatory drug (nsaid)-induced disease, and helicobacter pylori-induced gastroduodenitis. healing rates for duodenal ulcer with cbs are significantly better than with placebo and are similar to results obtained with cimetidine or ranitidine. cbs is significantly better in the treatment of duodenal ulcer res ... | 1991 | 1957121 |
| prostaglandin and helicobacter pylori-related non-ulcer dyspepsia. | | 1991 | 1962639 |
| hypothesis: helicobacter pylori, urease, mucus, and gastric ulcer. | ammonia, released in the gastric mucosa by the action of helicobacter pylori urease on transuded plasma urea, curtails the biosynthesis of mucus and/or causes the mucus to be disassembled at the mucosal surface. these changes facilitate colonisation by h pylori and may promote gastric ulcer formation. | 1990 | 1967668 |
| metronidazole-resistant helicobacter pylori. | | 1990 | 1968548 |
| helicobacter pylori, mucus, and gastric ulcer. | | 1990 | 1969087 |
| prevalence of campylobacter pylori as demonstrated by histology or clo-test in different types of gastritis. a study in 5 clinically predefined groups of patients. | the prevalence of campylobacter pylori infection as detected by histology was studied in 5 predefined groups of patients. the associated histologic and endoscopic findings were registered. validity of clo-test was tested against the histologic detection. the following groups of patients were studied: a) non-ulcer dyspepsia (defined by one or all of three symptoms: heartburn, nausea/inappetence, halitosis/belching) b) control group (no specific symptoms, no ulcer, no history of gastric surgery) c ... | 1990 | 1969152 |
| metronidazole resistance in helicobacter pylori. | | 1990 | 1970050 |
| helicobacter pylori acid resistance. | | 1990 | 1971083 |
| cure of duodenal ulcer associated with eradication of helicobacter pylori. | 50 patients with intractable duodenal ulcer were randomly assigned to 4 weeks of treatment with colloidal bismuth subcitrate (cbs) alone (26 patients) or with amoxicillin and metronidazole (24 patients). 5 patients (all on triple therapy) withdrew because of side-effects. in 17 of the 45 patients who completed the treatment, helicobacter pylori was eradicated, and there was no ulcer relapse during the first 12 months of follow-up. the ulcer relapse rate was significantly higher (17 of 21 [89%]) ... | 1990 | 1971318 |
| in vitro killing of helicobacter pylori with photodynamic therapy. | | 1990 | 1971363 |
| helicobacter pylori and hiv infection. | | 1990 | 1972223 |
| cure of peptic ulcer associated with eradication of helicobacter pylori. | | 1990 | 1972523 |
| vaccination against helicobacter pylori urease. | | 1990 | 1973509 |
| cure of duodenal ulcer after eradication of helicobacter pylori. | eighty-two patients, whose duodenal ulcers were recurrent or resistant to h2-receptor antagonist therapy, were entered in a treatment protocol of ranitidine followed by a four-week "triple therapy" course to eradicate helicobacter pylori (hp) infection. the triple therapy consisted of colloidal bismuth subcitrate, tetracycline and metronidazole. duodenal ulcer healed in all 78 patients available for endoscopy and h. pylori infection was shown to be eliminated in 75 patients (96%) at rebiopsy fou ... | 1990 | 1974027 |
| mixed gastric infection by gastrospirillum hominis and helicobacter pylori. | | 1990 | 1975013 |
| antibodies to helicobacter pylori in hiv infection. | | 1990 | 1975069 |
| treatment of helicobacter pylori positive duodenal ulcers. | | 1990 | 1975930 |
| gastroduodenal pathology and helicobacter pylori. third workshop of the european helicobacter pylori study group. proceedings. | | 1990 | 1977429 |
| therapy in helicobacter pylori infection. | | 1990 | 1978187 |
| pathogenesis and therapy of peptic ulcer disease. | the epithelial cells of the stomach and duodenum are normally protected from the damaging effects of acid and pepsin by a balancing mechanism of mucosal resistance. if an imbalance occurs, peptic ulcer may result. traditional teaching has emphasized the importance of acid (and pepsin) as the cause of this imbalance; however, it is clear that acid and pepsin are not the only important factors in the pathogenesis of peptic ulcer. more recent investigative efforts have been directed at what constit ... | 1990 | 1978840 |
| helicobacter pylori and metronidazole resistance. | | 1990 | 1978897 |
| sydney classification for gastritis and helicobacter pylori. | | 1990 | 1978898 |
| inhibition of helicobacter pylori by acetohydroxamic acid. | | 1990 | 1979397 |
| evaluation of urease test, gram stain, culture, and histology in the detection of campylobacter pylori. | to evaluate the commonly available tests for detection of campylobacter pylori infection in the human stomach, we prospectively performed endoscopy and biopsy from the antrum of the stomach in 121 consecutive patients. four tests, including the urease test, gram stain, culture, and the hematoxylin and eosin (h & e) stain were used to detect the presence of c. pylori. a c. pylori positive was defined by a positive culture or positive results in two of the other three tests. the sensitivity of the ... | 1990 | 1981231 |
| epidemiology and treatment of gastric campylobacter pylori infection: more questions than answers. | two-hundred and ten consecutive patients undergoing routine gastroscopy were additionally investigated for evidence of campylobacter pylori (c.p.). 106 patients were positive in one or more tests: 99.1% using a rapid urease detecting test (clo-test), 80.2% histology, 78.3% cytology and 60% culture. we found no difference between the clo-test results from biopsies taken from different parts of the stomach in individual patients. c.p. was found in 100% of patients with significant chronic antral g ... | 1990 | 1982107 |
| determinants of acid secretion. | acid secretion is regulated by hormonal factors acting peripherally and centrally, as well as neural factors. gastrin and histamine are the two most important peripheral hormonal stimulants, while the vagus is the predominant nerve affecting acid secretion. meal related acid secretion occurs in three phases: cephalic, gastric and intestinal. acid secretion is stimulated in the first two phases while it is inhibited in the intestinal phase. proteins are potent acid stimulants but carbohydrates an ... | 1990 | 1982628 |
| site-and cytoprotective drugs in the short-term treatment of peptic ulcer. what is their current role? | many endoscopically controlled comparisons with h2-blockers have widely documented that site- and cytoprotective drugs constitute effective and safe agents for the short-term treatment of gastric and duodenal ulcer. their efficacy however, is counter-acted by the need for multiple daily administration which requires greater patient compliance. due to its ability to eradicate helicobacter pylori (hp) from the gastric antrum and retard relapses, colloidal bismuth may be the first choice anti-ulcer ... | 1990 | 1983422 |
| diagnosis of campylobacter pylori gastritis. | campylobacter pylori is a bacterium that inhabits gastric mucosa. it causes chronic active gastritis and is highly associated with duodenal ulcer. campylobacter pylori has a urease enzyme (not present in man), which allows diagnosis by a [14c]urea breath test. we compared two noninvasive tests, the breath test and serum elisa, to biopsy and histologic diagnosis. twenty-two patients who underwent gastroduodenoscopy for evaluation of possible peptic ulcer disease entered the study. the breath test ... | 1991 | 1984994 |