| observational study of the effects of favipiravir vs lopinavir/ritonavir on clinical outcomes in critically ill patients with covid-19. | in november 2019, several patients were diagnosed with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in wuhan, china. so far, there are no specific treatments with proven high efficacy in patients with sars-cov-2. presently, several drugs, such as hydroxychloroquine, ribavirin, favipiravir (fvp), lopinavir/ritonavir (lpv/r), remdesivir and oseltamivir, have been suggested as effective treatments for sars-cov-2. the aim of this study was to describe the clinical experience with fpv ... | 2020 | 33128482 |
| analysis of humoral immune responses in sars-cov-2 infected patients. | the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection has caused a pandemic with tens of millions of cases and hundreds of thousands of deaths. the infection causes covid-19, a disease of the respiratory system of divergent severity. here, the humoral immune response of a cohort of 143 covid-19 patients from the university hospital frankfurt/main, germany was characterized. | 2020 | 33128369 |
| central nervous system manifestations associated with covid-19. | coronavirus disease 2019 (covid-19) has become a global health crisis of our time. the disease arises from severe acute respiratory syndrome coronavirus 2 (sars-cov-2) that binds to angiotensin-converting enzyme 2 (ace2) receptors on host cells for its internalization. covid-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. there is accumulating evidence to suggest that sars-cov-2 can target the nervous s ... | 2020 | 33128130 |
| molecular architecture of early dissemination and massive second wave of the sars-cov-2 virus in a major metropolitan area. | we sequenced the genomes of 5,085 severe acute respiratory syndrome coronavirus 2 (sars-cov-2) strains causing two coronavirus disease 2019 (covid-19) disease waves in metropolitan houston, tx, an ethnically diverse region with 7 million residents. the genomes were from viruses recovered in the earliest recognized phase of the pandemic in houston and from viruses recovered in an ongoing massive second wave of infections. the virus was originally introduced into houston many times independently. ... | 2020 | 33127862 |
| effects of coronavirus disease 2019 on solid organ transplantation. | as the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (sars-cov-2), has emerged as a viral pandemic, data on the clinical characteristics and outcomes of patients with sars-cov-2 infection undergoing solid organ transplant are emerging. the objective of this systematic review was to assess currently published literature relating to the management, clinical course, and outcome of sars-cov-2 infection in liver, kidney, and heart solid organ transplant recipients. | 2020 | 33127076 |
| willingness to accept trade-offs among covid-19 cases, social-distancing restrictions, and economic impact: a nationwide us study. | to conduct a discrete-choice experiment to quantify americans' acceptance of severe acute respiratory syndrome coronavirus 2 infection risks for earlier lifting of social-distancing restrictions and diminishing the pandemic's economic impact. | 2020 | 33127014 |
| are there pulmonary sequelae in patients recovering from covid-19? | it has been recently hypothesized that infection by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) may lead to fibrotic sequelae in patients recovering from coronavirus disease 2019 (covid-19). in this observational study, hospitalized patients with covid-19 had a hrct of the chest performed to detect the extension of fibrotic abnormalities via hounsfield units (hu). at follow-up, the lung density significantly improved in both lungs and in each lobe of all patients, being in the n ... | 2020 | 33126869 |
| outcomes of covid-19 hospitalized patients previously treated with renin-angiotensin system inhibitors. | (1) background: severe acute respiratory syndrome coronavirus 2 (sars-cov-2) penetrates respiratory epithelium through angiotensin-converting enzyme-2 binding, raising concerns about the potentially harmful effects of renin-angiotensin system inhibitors (rasi) on human coronavirus disease 2019 (covid-19) evolution. this study aimed to provide insight into the impact of rasi on sars-cov-2 outcomes in patients hospitalized for covid-19. (2) methods: this was a retrospective analysis of hospitalize ... | 2020 | 33126565 |
| opvcrispr: one-pot visual rt-lamp-crispr platform for sars-cov-2 detection. | the 2019 novel coronavirus disease (covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has affected all aspects of human life. rapid, accurate, sensitive and user friendly detection method is urgently needed to facilitate early intervention and control the spread of sars-cov-2. here, we propose a one-pot visual sars-cov-2 detection system named "opvcrispr" by integrating reverse transcription loop-mediated isothermal amplification (rt-lamp) and cas12a cleav ... | 2020 | 33126177 |
| anti-sars-cov-2 igg antibody response among indian covid-19 patients using β-propiolactone-inactivated, whole virus-based indirect elisa. | coronavirus disease 2019 (covid-19) pandemic caused by infection with severe acute respiratory syndrome - coronavirus-2 (sars-cov-2) continues to affect many countries and large populations. serologic assays for antibody detection aid patient diagnosis and seroepidemiologic investigations. | 2020 | 33126149 |
| sars-cov-2 in water services: presence and impacts. | the occurrence of human pathogenic viruses in aquatic ecosystems and, in particular, in internal water bodies (i.e., river, lakes, groundwater, drinking water reservoirs, recreational water utilities, and wastewater), raises concerns regarding the related impacts on environment and human health, especially in relation to the possibility of human exposure and waterborne infections. this paper reviews the current state of knowledge regarding severe acute respiratory syndrome coronavirus 2 (sars-co ... | 2020 | 33126033 |
| laboratory findings associated with severe illness and mortality among hospitalized individuals with coronavirus disease 2019 in eastern massachusetts. | the coronavirus disease 2019 (covid-19) pandemic has placed unprecedented stress on health systems across the world, and reliable estimates of risk for adverse hospital outcomes are needed. | 2020 | 33125498 |
| kidney ace2 expression: implications for chronic kidney disease. | angiotensin-converting enzyme 2 (ace2) has been implicated in the pathogenesis of chronic kidney disease (ckd) and is a membrane receptor for severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the virus responsible for coronavirus disease (covid-19), whereas transmembrane protease, serine 2 (tmprss2) is involved in viral attachment. together, tissue expression of ace2 and tmprss2 may determine infection. sex, age, body mass index (bmi), and ckd are clinical risk factors for covid-19 s ... | 2020 | 33125431 |
| the impact of covid-19 on allied health professions. | the purpose of the current study was to examine the impact of severe acute respiratory syndrome coronavirus 2 (sars-cov-2 or covid-19) on allied health professionals work environment, access to personal protective equipment (ppe) and covid-19 testing, and mental health. a 34-question survey was developed and distributed electronically to allied health professionals through listservs of professional organizations and social media groups. a total of 921 responses from allied health professionals i ... | 2020 | 33125385 |
| validation of a sars-cov-2 rna rt-pcr assay for high-throughput testing in blood of covid-19 convalescent plasma donors and patients. | the frequency of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) rnaemia in blood donors is uncertain. thus, assays for sars-cov-2 rna detection in blood, validated on commercially available polymerase chain reaction (pcr) systems, are required to allow a good comparability of data. | 2020 | 33125162 |
| cardiology and covid-19: do we have sufficient information? | novel coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2, which originated in wuhan (china), transformed into a worldwide pandemic. the short span associated with the spread of the virus and its varied manifestations presents a steep learning curve for many clinicians on the front-line of treatment. cardiology is one such affected area. this paper details the signs and symptoms of cardiovascular disease resulting from covid-19, including its proposed pa ... | 2020 | 33124920 |
| assessment of air and surfaces contamination in a covid-19 non-intensive care unit. | severe acute respiratory syndrome - coronavirus - 2 (sars-cov-2) is a virus, primarily transmitted through droplets, able to persist on different surfaces and in the air for several hours. during the covid-19 pandemic, health care workers should be considered a high risk profession. beside social distancing rules and the proper use of personal protective equipment, sanitization measures and ventilation system disinfection are essential to reduce viral transmission. | 2020 | 33124608 |
| the effects of aging on host resistance and disease tolerance to sars-cov-2 infection. | the ongoing coronavirus disease 2019 (covid-19) crisis caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has triggered a large-scale pandemic that is afflicting millions of individuals in over 200 countries. the clinical spectrum caused by sars-cov-2 infections can range from asymptomatic infection to mild undifferentiated febrile illness to severe respiratory disease with multiple complications. elderly patients (aged 60 and above) with co-morbidities such as cardiovascular ... | 2020 | 33124149 |
| are migraine patients at increased risk for symptomatic coronavirus disease 2019 due to shared comorbidities? | the coronavirus disease 2019 (covid-19) pandemic has rapidly transformed the whole world and forced us to look through comorbid diseases and risk factors from a different perspective. covid-19 shows some inherent risk factors like cardiovascular comorbidities independent from age, gender, and geographic location. one of the most peculiar features of the covid-19 pandemic is that severe acute respiratory syndrome coronavirus 2 respiratory infections disproportionately impact patients with hyperte ... | 2020 | 33124044 |
| immunoinflammatory, thrombohaemostatic, and cardiovascular mechanisms in covid-19. | the global coronavirus disease 2019 (covid-19) pandemic has deranged the recent history of humankind, afflicting more than 27 million individuals to date. while the majority of covid-19 patients recuperate, a considerable number of patients develop severe complications. bilateral pneumonia constitutes the hallmark of severe covid-19 disease but an involvement of other organ systems, namely the cardiovascular system, kidneys, liver, and central nervous system, occurs in at least half of the fatal ... | 2020 | 33124029 |
| kindergartens reopening in the period of regular epidemic prevention and control, benefitial or harmful? | in the period of regular epidemic prevention and control of coronavirus disease 2019 (covid-19) in our country, work resumption has been fully advanced. but there are still new sporadic local cases and imported cases across the country. in this situation, whether kindergartens reopening will increase the risk of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) spread still remains uncertain. we reviewed two pediatric patients with moderate covid-19, collected the epidemiologic inform ... | 2020 | 33123896 |
| clinical outcomes of dialysis patients with covid-19 in the initial phase of the covid-19 outbreak in wuhan, china. | since the end of 2019, dialysis patients have been at risk of coronavirus disease 2019 (covid-19) as well as other potential complications. hence, we sought to describe the clinical characteristics of dialysis patients with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection. | 2020 | 33123844 |
| impact of covid-19 on clinical and academic urological practice: a survey from european association of urology section of uro-technology. | the unexpected coronavirus disease 2019 (covid-19) pandemic has spread worldwide rapidly, developing into a global health crisis. at the same time, it has seriously impacted the daily activities in all the fields of urology. | 2020 | 33123688 |
| the psychological impact of the covid-19 pandemic and associated risk factors during the initial stage among the general population in india. | in the absence of treatment and unclear prognosis, severe acute respiratory syndrome coronavirus 2 (sars-cov-2) itself, and public health measures like lockdown enforced by the government to limit the spread of the virus poses a threat to the psychological health of the general population. | 2021 | 33123627 |
| the role of nicotinic receptors in sars-cov-2 receptor ace2 expression in intestinal epithelia. | recent evidence demonstrated that severe acute respiratory syndrome coronavirus 2 (sars-cov-2) propagates in intestinal epithelial cells expressing angiotensin-converting enzyme 2 (ace2), implying that these cells represent an important entry site for the viral infection. nicotinic receptors (nachrs) have been put forward as potential regulators of inflammation and of ace2 expression. as vagus nerve stimulation (vns) activates nachrs, we aimed to investigate whether vns can be instrumental in af ... | 2020 | 33123616 |
| epidemiological and clinical findings of short-term recurrence of severe acute respiratory syndrome coronavirus 2 ribonucleic acid polymerase chain reaction positivity in 1282 discharged coronavirus disease 2019 cases: a multicenter, retrospective, observational study. | short-term recurrence of positive severe acute respiratory syndrome coronavirus 2 (sars-cov-2) ribonucleic acid (rna) polymerase chain reaction (pcr) in discharged coronavirus disease 2019 (covid-19) patients attracts the public's concern. this study aimed to determine the clinical and epidemiological results of such patients. | 2020 | 33123610 |
| transmission of sars-cov-2 in public transportation vehicles: a case study in hunan province, china. | here we report a case study of a severe acute respiratory syndrome coronavirus 2 (sars-cov-2) outbreak event during bus trips of an index patient in hunan province, china. this retrospective investigation suggests potential airborne transmission of sars-cov-2 and the possibility of superspreading events in certain close contact and closed space settings, which should be taken into account when control strategies are planned. | 2020 | 33123609 |
| spontaneous pneumomediastinum associated with covid-19 pneumonia. | the first case of coronavirus disease 2019 (covid-19) was declared in december in wuhan, before becoming a global pandemic in a few weeks. several complications of this infection have been reported. however, a spontaneous pneumomediastinum has rarely been described. we report the fourth case of this extremely rare complication in a 65-year-old male patient with severe acute respiratory syndrome coronavirus-2 (sars-cov-2) pneumonia, discovered during his therapeutic management by a ct scan contro ... | 2020 | 33123202 |
| pro- and anti-inflammatory responses in severe covid-19-induced acute respiratory distress syndrome-an observational pilot study. | the severity of coronavirus disease 2019 (covid-19) is largely determined by the immune response. first studies indicate altered lymphocyte counts and function. however, interactions of pro- and anti-inflammatory mechanisms remain elusive. in the current study we characterized the immune responses in patients suffering from severe covid-19-induced acute respiratory distress syndrome (ards). | 2020 | 33123167 |
| immunesenescence: a predisposing risk factor for the development of covid-19? | bearing a strong resemblance to the phenotypic and functional remodeling of the immune system that occurs during aging (termed immunesenescence), the immune response to severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the causative agent of coronavirus disease 2019 (covid-19), is characterized by an expansion of inflammatory monocytes, functional exhaustion of lymphocytes, dysregulated myeloid responses and the presence of highly activated senescent t cells. alongside advanced age, ... | 2020 | 33123152 |
| quantification of antibody avidities and accurate detection of sars-cov-2 antibodies in serum and saliva on plasmonic substrates. | accurate assays for the detection of antibodies to sars-cov-2 (severe acute respiratory syndrome coronavirus 2) are essential for the control of the covid-19 (coronavirus disease 2019) pandemic. here, we report antibody and antibody-avidity assays, relying on near-infrared-fluorescence amplification by nanostructured plasmonic gold substrates, for the simultaneous detection of antibodies to the s1 subunit of the spike protein and to the receptor binding domain of sars-cov-2 in human serum and sa ... | 2020 | 33122853 |
| kinetics of sars-cov-2 positivity of infected and recovered patients from a single center. | recurrence of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) positive detection in infected but recovered individuals has been reported. patients who have recovered from coronavirus disease 2019 (covid-19) could profoundly impact the health care system. we sought to define the kinetics and relevance of pcr-positive recurrence during recovery from acute covid-19 to better understand risks for prolonged infectivity and reinfection. a series of 414 patients with confirmed sars-cov-2 i ... | 2020 | 33122706 |
| an 89-year-old man with covid-19-associated coagulopathy presenting with a prolonged partial thromboplastin time, lupus anticoagulant, and a high titer of factor viii inhibitor. | background coagulation abnormalities are frequently encountered in patients with coronavirus disease 2019 (covid-19), especially in those with more severe disease. these hematologic abnormalities are suspected to occur in the context of underlying immune dysregulation and endothelial dysfunction. elevated d-dimer levels, covid-19-associated coagulopathy (cac), disseminated intravascular coagulation (dic), and positive lupus anticoagulants are the most common findings to date. current guidelines ... | 2020 | 33122620 |
| brain mr spectroscopic findings in 3 consecutive patients with covid-19: preliminary observations. | brain multivoxel mr spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (covid-19). these included 1 patient with covid-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. the mr spectroscopic imaging findings were compared with those of 2 patients with white matter patholo ... | 2020 | 33122208 |
| repurposing nucleoside analogs for human coronaviruses. | coronavirus disease 2019 (covid-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2 or cov-2). some reports claimed certain nucleoside analogs to be active against cov-2, and thus needed confirmation. here, we evaluated a panel compounds and identified novel nucleoside analogs with antiviral activity against cov-2 and hcov-oc43 while ruling out others. of significance sofosbuvir demonstrated no antiviral effect against cov-2 and its triphosphate did not ... | 2020 | 33122172 |
| sars, mers, and covid-19: what's next? | | 2020 | 33122154 |
| external quality assessment for molecular detection of severe acute respiratory syndrome coronavirus 2 in clinical laboratories. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) poses a huge threat to public health. viral nucleic acid testing is the diagnostic gold standard and can play an important role in the prevention and control of this infection. in this study, bacteriophage ms2 virus-like particles encapsulating specific rna sequences of sars-cov-2 and other coronaviruses were prepared by genetic engineering. the assessment panel, consisting of four positive samples with concentrations of 2.8, 3.5, 4.2 ... | 2020 | 33122140 |
| covid-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study. | the aim of this study was to describe the outcomes of patients with coronavirus disease 2019 (covid-19) in the outpatient setting after early treatment with zinc, low-dose hydroxychloroquine and azithromycin (triple therapy) dependent on risk stratification. this was a retrospective case series study in the general practice setting. a total of 141 covid-19 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection in the year 2020 were included. the ... | 2020 | 33122096 |
| perioperative management of patients with suspected or confirmed covid-19: review and recommendations for perioperative management from a retrospective cohort study. | current guidelines for perioperative management of coronavirus disease 19 (covid-19) are mainly based on extrapolated evidence or expert opinion. we aimed to systematically investigate how covid-19 affects perioperative management and clinical outcomes, to develop evidence-based guidelines. | 2020 | 33121750 |
| measuring the serologic response to severe acute respiratory syndrome coronavirus 2: methods and meaning. | the entire spectrum of diagnostic testing, from reagent supply to test performance, has been a major focus during the coronavirus disease 2019 (covid-19) pandemic. the hope for serologic testing is that it will provide both epidemiologic information about seroprevalence as well as individual information about previous infection. this information is particularly helpful for high-risk individuals who may be outside of the viral shedding window, such as children with suspected multisystem inflammat ... | 2020 | 33121625 |
| covid-19 and autoimmune diseases: a systematic review of reported cases. | over 4.9 million cases of coronavirus disease 2019 (covid-19) have been confirmed since the worldwide pandemic began. since the emergence of covid-19, a number of confirmed cases reported autoimmune manifestations. herein, we reviewed the reported covid-19 cases with associated autoimmune manifestations. | 2020 | 33121413 |
| sars-cov-2 vaccine candidates in rapid development. | the covid-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is still spreading globally. the scientific community is attempting to procure an effective treatment and prevention strategy for covid-19. a rising number of vaccines for covid-19 are being developed at an unprecedented speed. development platforms include traditional inactivated or live attenuated virus vaccines, dna or rna vaccines, recombinant viral vector vaccines, and protein or peptide subunit ... | 2020 | 33121319 |
| the role of covid-19 in the death of sars-cov-2-positive patients: a study based on death certificates. | background: death certificates are considered the most reliable source of information to compare cause-specific mortality across countries. the aim of the present study was to examine death certificates of persons who tested positive for severe acute respiratory syndrome coronavirus 2 (sars-cov-2) to (a) quantify the number of deaths directly caused by coronavirus 2019 (covid-19); (b) estimate the most common complications leading to death; and (c) identify the most common comorbidities. methods ... | 2020 | 33121176 |
| covid-19-associated neurological disorders: the potential route of cns invasion and blood-brain relevance. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is a novel human coronavirus that has sparked a global pandemic of the coronavirus disease of 2019 (covid-19). the virus invades human cells through the angiotensin-converting enzyme 2 (ace2) receptor-driven pathway, primarily targeting the human respiratory tract. however, emerging reports of neurological manifestations demonstrate the neuroinvasive potential of sars-cov-2. this review highlights the possible routes by which sars-cov- ... | 2020 | 33120941 |
| statins and sars-cov-2 disease: current concepts and possible benefits. | inflammation-mediated tissue injury is the major mechanism involved in the pathogenesis of coronavirus disease 2019 (covid-2019), caused by severe acute respiratory syndrome-coronavirus-2 (sars-cov-2). statins have well-established anti-inflammatory, anti-thrombotic and immuno-modulatory effects. they may also influence viral entry into human cells. | 2020 | 33120281 |
| [covid-19 and work environment: legislative developments about the role of the occupational physician in the emergency management and in the sars-cov-2-related work accidents notification]. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and its associated disease (covid-19) represent a global health emergency that requires integrated and multidisciplinary intervention by international medical and scientific communities, in support of the national governments. in italy many public health measures have been adopted to contain the transmission of the disease, which also involved occupational physicians. the regulatory path has had a rapid evolution due to the trend of in ... | 2020 | 33119980 |
| [covid-19 emergency management activities promoted by an university hospital in northern italy]. | background. in december 2019, a coronavirus 2019 epidemic (covid-19) was reported, caused by a severe acute respiratory syndrome coronavirus 2 (sars-cov-2), which occurred in the city of wuhan, hubei province, china. perceived risk of contracting diseases has led many governments and healthcare organizations to implement a variety of control and protection measures for the population, in particular for health professionals who have made contact with positive covid-19 patients. in this publicatio ... | 2020 | 33119979 |
| fully automated dried blood spot sample handling and extraction for serological testing of sars-cov-2 antibodies. | at the beginning of 2020, an outbreak of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) reached pandemic dimensions. throughout the event, diagnostic tests function as an essential tool for understanding, mitigating, and implement strategies to curb and reduce infections. here, we present a novel method for the fully automated dried blood spot (dbs) sample handling and extraction for serological testing of human igg antibodies against sars-cov-2 using a commercial enzyme-linked imm ... | 2020 | 33119946 |
| dose-response relation deduced for coronaviruses from covid-19, sars and mers meta-analysis results and its application for infection risk assessment of aerosol transmission. | a comprehensive understanding of the transmission routes of the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is of great importance for the effective control of the spread of corona virus disease 2019 (covid-19). however, the fundamental dose-response relation is still missing for better evaluating and controlling the infection risk. | 2020 | 33119733 |
| sars-cov-2 rna shedding in recovered covid-19 cases and the presence of antibodies against sars-cov-2 in recovered covid-19 cases and close contacts, thailand, april-june 2020. | coronavirus disease 2019 (covid-19) is caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2). although thailand has been fairly effective at controlling the spread of covid-19, continued disease surveillance and information on antibody response in recovered patients and their close contacts remain necessary in the absence of approved vaccines and antivirals. here, we examined 217 recovered covid-19 patients to assess their viral rna shedding and residual antibodies against s ... | 2020 | 33119712 |
| sars-cov-2 in the amazon region: a harbinger of doom for amerindians. | as the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) pandemic continues to expand, healthcare resources globally have been spread thin. now, the disease is rapidly spreading across south america, with deadly consequences in areas with already weakened public health systems. the amazon region is particularly susceptible to the widespread devastation from coronavirus disease 2019 (covid-19) because of its immunologically fragile native amerindian inhabitants and epidemiologic vulner ... | 2020 | 33119616 |
| integrated survival estimates for cancer treatment delay among adults with cancer during the covid-19 pandemic. | cancer treatment delay has been reported to variably impact cancer-specific survival and coronavirus disease 2019 (covid-19)-specific mortality during the severe acute respiratory syndrome coronavirus 2 pandemic. during the pandemic, treatment delay is being recommended in a nonquantitative, nonobjective, and nonpersonalized manner, and this approach may be associated with suboptimal outcomes. quantitative integration of cancer mortality estimates and data on the consequences of treatment delay ... | 2020 | 33119036 |
| a sars-cov-2 variant with the 12-bp deletion at e gene. | the coronavirus disease 2019 (covid-19) pandemic is still ongoing and has become an important public health threat. this disease is caused by a new coronavirus named severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection, and so far, little is known about this virus. in this study, by using plaque purification, we purified two sars-cov-2 virus strains from the same specimen, one named f8 containing a 12-bp deletion in the e gene and the other named 8x containing the wild-type e g ... | 2020 | 33118859 |
| covid-19 - endothelial axis and coronary artery bypass graft patency: a target for therapeutic intervention? | it has been reported that severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection induces endothelial inflammation, therefore facilitating the progression of endothelial and vascular dysfunction in coronavirus disease 2019 (covid-19) patients. coronary artery bypass grafting (cabg) involves mainly the use of the saphenous vein (sv) and internal mammary artery as graft material in the stenosed coronary arteries. unfortunately, graft patency of the sv is low due to endothelial dysfu ... | 2020 | 33118741 |
| expression of eosinophil in peripheral blood of patients with covid-19 and its clinical significance. | to investigate the eosinophil cell (ec) expression in peripheral blood of patients infected with severe acute respiratory syndrome coronavirus 2(sars-cov-2) and its clinical significance of diagnosis and prognosis. | 2020 | 33118666 |
| sars-cov-2 and hiv: epidemiology, treatment, and lessons learned from hiv. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the cause of covid-19, was first detected in china in december 2019 and has rapidly spread throughout the world. globally, the impact of covid-19 has been severe with more than half a million deaths over 6 months; in contrast, the hiv pandemic has resulted in over 32 million deaths worldwide over 40 years. this paper reviews the current epidemiology of covid-19, summarizes its relationship to hiv, identifies synergies in our response, ... | 2020 | 33118529 |
| consensus statement on coronary intervention during the coronavirus disease 2019 (covid-19) pandemic: from the korean society of interventional cardiology (ksic). | coronavirus disease 2019 (covid-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus-2. the first case developed in december, 2019 in wuhan, china; several months later, covid-19 has become pandemic, and there is no end in sight. this disaster is also causing serious health problems in the area of cardiovascular intervention. in response, the korean society of interventional cardiology formed a covid-19 task force to develop practice guidelin ... | 2020 | 33118332 |
| fangcang shelter hospitals are a one health approach for responding to the covid-19 outbreak in wuhan, china. | in february 2020, the exponential growth of covid-19 cases in wuhan city posed a huge economic burden to local medical systems. consequently, wuhan established fangcang shelter hospitals as a one health approach for responding to and containing the covid-19 outbreak by isolating and caring for mild-to-moderate cases. however, it is unclear to what degree the hospitals contained covid-19. this study performed an interrupted time series analysis to compare the number of new confirmed cases of covi ... | 2020 | 33117879 |
| upper respiratory tract viral ribonucleic acid load at hospital admission is associated with coronavirus disease 2019 disease severity. | the outbreak of coronavirus disease 2019 (covid-19) has aroused global public health concerns. multiple clinical features relating to host profile but not for virus have been identified as the risk factors for illness severity and/or the outcomes in covid-19. | 2020 | 33117856 |
| symptoms of covid-19 outpatients in the united states. | severe acute respiratory syndrome coronavirus-2 (sars-cov-2) is a novel pathogen causing the current worldwide coronavirus disease 2019 (covid-19) pandemic. due to insufficient diagnostic testing in the united states, there is a need for clinical decision-making algorithms to guide testing prioritization. | 2020 | 33117855 |
| spread of coronavirus 2019 from wuhan to rural villages in the hubei province. | this study aimed to describe the spread of coronavirus disease 2019 (covid-19) from wuhan to rural villages in the hubei province. | 2020 | 33117853 |
| air evacuation of passengers with potential sars-cov-2 infection under the guidelines for appropriate infection control and prevention. | this report describes the air evacuation of 80 koreans from iran to korea on march 19th, 2020, with a direct transfer of passengers between airplanes in dubai. the passengers were potentially infected with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) so, strict precautions were taken for the duration of the flight, and the passengers were screened before embarking from dubai and disembarking at incheon international airport in korea. passengers with fever or symptoms of sars-cov- ... | 2020 | 33117639 |
| eculizumab, sars-cov-2 and atypical hemolytic uremic syndrome. | atypical hemolytic uremic syndrome (ahus) treatment consists of eculizumab. severe acute respiratory syndrome coronavirus 2 causes severe pneumonia and endothelial injury that leads to a prothrombotic state that may be complicated by macrovascular and microvascular thrombosis. complement activation is thought to contribute to endothelial injury and there are at least seven ongoing clinical trials testing six different anti-complement strategies for coronavirus disease 2019 (covid-19), including ... | 2020 | 33117528 |
| prospects of plasmapheresis for patients with severe covid-19. | on february 11, 2020, the world health organization officially named the infection caused by the new coronavirus "coronavirus disease 2019" (covid-19). on february 11, 2020, the international committee on taxonomy of viruses (ictv) officially named the infectious matter "severe acute respiratory syndrome coronavirus 2" (sars-cov-2). emergence of severe complications with new coronavirus disease is due to the development of hypercytokinaemia, also known as "cytokine storm". these complications co ... | 2020 | 33117508 |
| the sars-cov-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens. | the ongoing pandemic of coronavirus disease 2019 (covid-19), caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2), poses a grave threat to global public health and imposes a severe burden on the entire human society. like other coronaviruses, the sars-cov-2 genome encodes spike (s) glycoproteins, which protrude from the surface of mature virions. the s glycoprotein plays essential roles in virus attachment, fusion and entry into the host cell. surface location of the s glycopro ... | 2020 | 33117378 |
| current options in the treatment of covid-19: a review. | novel coronavirus, also known as severe acute respiratory syndrome coronavirus 2 (sars-cov-2), emerged in december 2019 in china and spread rapidly all around the world infecting many people. to date, no specific vaccines and drugs have been developed for this disease. also, due to the covid-19 pandemic and high prevalence of the infected patients, the drugs and the therapies of other past viral epidemics have been used for this disease. many studies have been performed on the specific treatment ... | 2020 | 33116980 |
| epidemiologic and clinical characteristics of covid-19 patients from a quarantine center in a developing community: a retrospective study. | coronavirus disease 2019 (covid-19) is an ongoing infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) agent, and is generally known as novel coronavirus. the impact of the disease has had apparent effects on health, social, and economic levels. this study aimed to investigate the epidemiologic features, clinical presentations, laboratory examination, and outcomes of covid-19 patients in jordan. | 2020 | 33116785 |
| cytokine response in sars-cov-2 infection in the elderly. | the last few months of 2019 witnessed the emergence, rise and rapid spread of a novel coronavirus known as severe acute respiratory syndrome coronavirus-2 (sars-cov-2), causing an acute respiratory disease called coronavirus disease 2019 or covid-19. severe pathological manifestations of the disease in the infected population with comorbidities are linked to acute respiratory distress syndrome (ards), associated with an exaggerated synthesis and expression of cytokines, leading to a systemic inf ... | 2020 | 33116752 |
| inflammatory cytokine: il-17a signaling pathway in patients present with covid-19 and current treatment strategy. | coronavirus disease 2019 (covid-19) is a globally communicable public health disease caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2). eradication of covid-19 appears practically impossible but, therefore, more effective pharmacotherapy is needed. the deteriorated clinical presentation of patients with covid-19 is mainly associated with hypercytokinemia due to notoriously elevated pro-inflammatory cytokines such as interleukin (il)-1b, il-6, il-8, il-17, granulocyte-macroph ... | 2020 | 33116747 |
| flattening the risk: pre-exposure prophylaxis for covid-19. | to date, more than 35 million people worldwide have been infected with severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the agent of coronavirus disease 2019 (covid-19), and more than one million have died in the covid-19 pandemic. international economies are stalled and social isolation based on palpable fear of death remains the order of the day. the united states and other countries are moving toward resuming work activities and social interaction to boost economic recovery. whil ... | 2020 | 33116688 |
| predictors of severity and co-infection resistance profile in covid-19 patients: first report from upper egypt. | the emerging severe acute respiratory syndrome coronavirus 2 (sars-cov-2) resulted in a worldwide devastating effect with a diagnostic challenge. identifying risk factors of severity aids in assessment for the need of early hospitalization. we aimed to demonstrate, for the first time, the clinical, laboratory and radiological characteristics of coronavirus disease 2019 (covid-19) patients, to identify the predictors of severity and to describe the antimicrobial resistance profile in patients fro ... | 2020 | 33116660 |
| glycopeptides as potential interventions for covid-19. | coronavirus disease 2019 (covid-19), an infectious disease that primarily attacks the human pulmonary system, is caused by a viral strain called severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the outbreak emerged from wuhan, china, and later spread throughout the world. until the first week of may 2020, over 3.7 million cases had been reported worldwide and more than 258,000 had died due to the disease. so far, off label use of various drugs has been tried in many clinical setting ... | 2020 | 33116397 |
| molecular detection of human coronavirus from north central part of bangladesh depending on orf1ab and n gene. | the coronavirus disease 2019 (covid-19) resulted severe respiratory illness such as pneumonia and lung dysfunctions that was first identified at wuhan, the capital of hubeiin china during the end of december 2019. the etiological cause of covid-19 has been confirmed as a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (sars-cov-2) which was similar with the zoonotic virus sars-cov (2002). now a days for early diagnosis of covid-19 the nucleic acid based test like rt pc ... | 2020 | 33116089 |
| bilateral central retinal vein occlusion in a 40-year-old man with severe coronavirus disease 2019 (covid-19) pneumonia. | background covid-19 is the disease caused by the novel virus, severe acute respiratory syndrome coronavirus 2 (sars-cov-2). the spectrum of disease seen in patients with covid-19 infection ranges from asymptomatic or mild symptoms to severe pneumonia and even acute respiratory distress syndrome, which often requires invasive ventilation and intensive care. covid-19-associated infection can be catastrophic, leading to both arterial and venous occlusion, microinfarcts, and multiorgan failure, alth ... | 2020 | 33116072 |
| severe acute respiratory syndrome coronavirus 2 (sars-cov-2) antibodies at delivery in women, partners, and newborns. | to investigate the frequency of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) antibodies in parturient women, their partners, and their newborns and the association of such antibodies with obstetric and neonatal outcomes. | 2020 | 33116054 |
| will vaccination refusal prolong the war on sars-cov-2? | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is a novel coronavirus that appeared in wuhan, china in january 2020 and caused a global pandemic drastically changing everyday life. currently, there are vaccine candidates in clinical trials and development, so it is only a matter of time before one is authorised for human use. | 2020 | 33115909 |
| a biomarker-centric approach to drug discovery and development: lessons learned from the covid-19 pandemic. | faced with the health and economic consequences of the global spread of severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the biomedical community came together to identify, diagnose, prevent, and treat the novel disease at breathtaking speeds. the field advanced from a publicly available viral genome to a commercialized globally scalable diagnostic biomarker test in less than 2 months, while first-in-human dosing with vaccines and repurposed antivirals followed shortly thereafter. t ... | 2020 | 33115823 |
| co-infection of sars-cov-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of covid-19. | we performed a study during the early outbreak period of coronavirus disease 2019 (covid-19) and the seasonal epidemics of other respiratory viral infections in order to describe the extent of co-infections of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) with other respiratory viruses. a second objective consisted in the comparison of the diagnostic performances of urt and lrt samples for sars-cov-2 infection and to compare diagnostic performances of upper and lower respiratory t ... | 2020 | 33115679 |
| the impact of oxidative stress damage induced by the environmental stressors on covid-19. | the ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is a substantial stressor that is greatly impacting environmental sustainability. besides, the different pre-existing environmental stressors and coronavirus disease-2019 (covid-19)-related stressors are further worsening the effects of the viral disease by inducing the generation of oxidative stress. the generated oxidative stress results in nucleic acid damage associated with viral mutations, that c ... | 2020 | 33115606 |
| chloroquine and hydroxychloroquine in covid-19: practice implications for healthcare professionals. | chloroquine (cq) and its derivatives such as hydroxychloroquine (hcq) remain mainstay of therapy for malaria. these drugs are also approved for certain autoimmune diseases including systemic lupus erythematosus. the antiviral activities of these drugs and their mechanisms have been studied in vitro previously against various viruses including severe acute respiratory syndrome coronavirus (sars-cov). during the current coronavirus disease 2019 (covid-19) pandemic, in vivo and in vitro investigati ... | 2020 | 33115586 |
| covid-19 and dental education in pakistan. | the spread of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has infected more than 6 million people globally; and changed the dynamics of the entire world. in march 2020, novel coronavirus disease 2019 (covid-19) was declared as a pandemic by the world health organization (who). in pakistan, the first case of covid-19 was reported on 26th february, 2020. the virus is highly contagious and spreads mainly by aerosols. its major symptoms include sore throat, cough, high-grade fever, ... | 2020 | 33115583 |
| a survey of preparedness against coronavirus disease 2019 (covid-19) in hospitals in tokyo, japan, with healthcare personnel with covid-19 and in-facility transmission. | a questionnaire was distributed to hospitals in tokyo (n = 38) regarding their preparedness against and in-facility transmission of coronavirus disease 2019 (covid-19). as of may 31, 2020, 284 hcp had contracted covid-19, and in-facility covid-19 transmission occurred at 13 hospitals, negatively impacting hospital functions and patient care. | 2020 | 33115548 |
| impacts of reopening strategies for covid-19 epidemic: a modeling study in piedmont region. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2), the causative agent of the coronavirus disease 19 (covid-19), is a highly transmittable virus. since the first person-to-person transmission of sars-cov-2 was reported in italy on february 21st, 2020, the number of people infected with sars-cov-2 increased rapidly, mainly in northern italian regions, including piedmont. a strict lockdown was imposed on march 21st until may 4th when a gradual relaxation of the restrictions started. in ... | 2020 | 33115434 |
| nucleic acid and immunological diagnostics for sars-cov-2: processes, platforms and pitfalls. | accurate diagnosis at an early stage of infection is essential for the successful management of any contagious disease. the coronavirus disease 2019 (covid-19), caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) virus is a pandemic that has affected 214 countries affecting more than 37.4 million people causing 1.07 million deaths as of the second week of october 2020. the primary diagnosis of the infection is done either by the molecular technique of rt-qpcr by detecting ... | 2020 | 33114057 |
| short term follow-up of patients presenting with acute onset diabetes and diabetic ketoacidosis during an episode of covid-19. | acute onset diabetes and diabetic ketoacidosis (dka) can be precipitated by severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection in individuals with no history of diabetes. however, data regarding the follow-up of these individuals are scarce. | 2020 | 33113470 |
| sars-cov-2 infects the brain choroid plexus and disrupts the blood-csf barrier in human brain organoids. | coronavirus disease 2019 (covid-19), caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) virus, leads to respiratory symptoms that can be fatal. however, neurological symptoms have also been observed in some patients. the cause of these complications is currently unknown. here, we use human-pluripotent-stem-cell-derived brain organoids to examine sars-cov-2 neurotropism. we find expression of viral receptor ace2 in mature choroid plexus cells expressing abundant lipoprotei ... | 2020 | 33113348 |
| high-density amplicon sequencing identifies community spread and ongoing evolution of sars-cov-2 in the southern united states. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is constantly evolving. prior studies focused on high-case-density locations, such as the northern and western metropolitan areas of the united states. this study demonstrates continued sars-cov-2 evolution in a suburban southern region of the united states by high-density amplicon sequencing of symptomatic cases. 57% of strains carry the spike d614g variant, which is associated with higher genome copy numbers, and its prevalence expan ... | 2020 | 33113345 |
| coronary artery bypass graft during the covid-19 pandemic. | since the beginning of the coronavirus disease (covid-19) pandemic, in march 2020, the number of people infected with covid-19 worldwide increases continuously. brazil is being followed with great concern in the international media, as it can, very soon, be the epicenter of the pandemic. initial surgical data suggest that patients who acquire covid-19 in the perioperative period are prone to a higher morbidity and mortality, however, evidence in cardiac surgery is still scarce. this article aims ... | 2020 | 33113324 |
| sars-cov-2 neutralizing antibody ly-cov555 in outpatients with covid-19. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) causes coronavirus disease 2019 (covid-19), which is most frequently mild yet can be severe and life-threatening. virus-neutralizing monoclonal antibodies are predicted to reduce viral load, ameliorate symptoms, and prevent hospitalization. | 2020 | 33113295 |
| pediatric stroke associated with a sedentary lifestyle during the sars-cov-2 (covid-19) pandemic: a case report on a 17-year-old. | the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) pandemic-associated quarantine has led to a more sedentary lifestyle in teenagers. this may increase the risk for venous thromboembolism and a subsequent source of an ischemic stroke through a patent foramen ovale (pfo). here, we report a pediatric stroke case likely due to these factors. | 2020 | 33113054 |
| mechanisms and potential therapeutic targets of hyperinflammatory responses in sars-cov2. | coronavirus infection is now the leading cause of death globally. despite the several bedsides- to- bench investigations carried out by researchers all over the world to identify the best prophylactic and therapeutic options for this deadly virus, no novel vaccine or treatment drug has been developed. accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2 (sars -cov2) is associated with hyper inflammation characterized by excessive release of pro-inflammatory cytokin ... | 2020 | 33112637 |
| guillain-barré syndrome associated with sars-cov-2 infection: a systematic review and individual participant data meta-analysis. | several published reports have described a possible association between guillain-barré syndrome (gbs) and severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection. this systematic review aimed to summarize and meta-analyze the salient features and prognosis of sars-cov-2-associated gbs. we searched the pubmed (medline), web of science and cochrane databases for articles published between 01 january 2020 and 05 august 2020 using sars-cov-2 and gbs-related keywords. data on sociodemo ... | 2020 | 33112450 |
| multivariate mortality analyses in covid-19: comparing patients with cancer and patients without cancer in louisiana. | this is the largest and only multivariate study evaluating the difference in mortality from coronavirus disease 2019 (covid-19) between patients with cancer and patients without cancer in the united states. the objective was to assess covid-19 mortality rates in patients with cancer versus patients without cancer and uncover possible statistically significant characteristics contributing to mortality. | 2020 | 33112411 |
| targeting crucial host factors of sars-cov-2. | coronavirus disease 2019 (covid-19), caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2), has spread worldwide since its first incidence in wuhan, china, in december 2019. although the case fatality rate of covid-19 appears to be lower than that of sars and middle east respiratory syndrome (mers), the higher transmissibility of sars-cov-2 has caused the total fatality to surpass other viral diseases, reaching more than 1 million globally as of october 6, 2020. the rate at whic ... | 2020 | 33112126 |
| sars-cov-2 and arbovirus infection: a rapid systematic review. | the numbers of cases of arboviral diseases have increased in tropical and subtropical regions while the coronavirus disease (covid-19) pandemic overwhelms healthcare systems worldwide. the clinical manifestations of arboviral diseases, especially dengue fever, can be very similar to covid-19, and misdiagnoses are still a reality. in the meantime, outcomes for patients and healthcare systems in situations of possible syndemic have not yet been clarified. | 2020 | 33111923 |
| sars-cov-2 isolation from the first reported patients in brazil and establishment of a coordinated task network. | severe acute respiratory syndrome coronavirus 2 (sars-cov-2) was confirmed in brazil in february 2020, the first cases were followed by an increase in the number of cases throughout the country, resulting in an important public health crisis that requires fast and coordinated responses. | 2020 | 33111751 |
| in silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties. | coronavirus disease 2019 (covid-19) has infected more than thirty five million people worldwide and caused nearly 1 million deaths as of october 2020. the microorganism causing covid-19 was named as severe acute respiratory syndrome coronavirus 2 (sars-cov-2 or 2019-ncov). the aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (rbd) of the spike glycoprotein of 2019-ncov, and cellular pr ... | 2020 | 33111622 |
| covid19 in solid organ transplantation: an analysis of the impact on transplant activity and waitlists. | the limited knowledge about covid19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) makes mortality figures hard to interpret in the undetermined prevalence of an asymptomatic infection. treatments are currently being tested, but without proof of an effective vaccination, the fear of further detrimental outcomes, due to a second wave, persists. one of the main differences in the death toll among the various countries seems related to the different response ... | 2020 | 33111334 |
| ocular manifestation, comorbidities, and detection of severe acute respiratory syndrome-coronavirus 2 from conjunctiva in coronavirus disease 2019: a systematic review and meta-analysis. | the coronavirus disease 2019 (covid 19) pandemic has presented major challenges to ophthalmologists. reports have shown that ocular manifestations can be the first presenting symptoms of covid 19 infection and conjunctiva may be a portal of entry for the severe acute respiratory syndrome (sars) associated coronavirus 2 (sars cov 2). the purpose of this article is to provide general guidance for ophthalmologists to understand the prevalence of ocular presentation in covid 19 patients and to reduc ... | 2020 | 33110745 |
| hypoxia, hif-1α, and covid-19: from pathogenic factors to potential therapeutic targets. | the pandemic of coronavirus disease 2019 (covid-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (sars-cov-2) have become the greatest current threat to global public health. the highly infectious sars-cov-2 virus primarily attacks pulmonary tissues and impairs gas exchange leading to acute respiratory distress syndrome (ards) and systemic hypoxia. the current pharmacotherapies for covid-19 largely rely on supportive and anti-thrombi treatment and the repurposing of antimala ... | 2020 | 33110240 |