| production and characterization of monoclonal antibodies to cell wall antigens of aspergillus fumigatus. | two murine monoclonal antibodies (mabs) against aspergillus fumigatus were produced and characterized. splenocytes from cell wall-immunized balb/c mice were fused with sp2/0 myeloma cells. the hybridomas were screened with a cold alkali (ca) extract of mycelium containing protein, mannose, and galactose, and two mabs of the immunoglobulin m class were purified from ascites fluid. mabs 1 and 40 were characterized by double immunodiffusion against ca antigen, indirect enzyme immunoassay with manna ... | 1990 | 2194959 |
| nebulized amphotericin b as prophylaxis against invasive aspergillosis in granulocytopenic patients. | the efficacy of inhaled amphotericin b in prevention of invasive aspergillosis in patients with granulocytopenia (granulocytes less than 0.5 x 10(9)/l for greater than 10 days) was investigated over a 12-month period. amphotericin b prophylaxis was administered twice daily for the period of granulocytopenia to 34 patients who were at risk during 144 episodes of granulocytopenia. the cohort at risk was compared with historical controls. in the 2 years prior to institution of prophylaxis, 14 patie ... | 1990 | 2196098 |
| [various forms of humidifier lung]. | clinical and immunological investigations of 15 workers in a repro-printing house revealed a prevalence of 7% for the occurrence of humidifier-lung. serological sensitization to humidifier water and fungi respectively was found in 73%, fragmentary symptoms in 53%. in comparison to smokers, elevated antibody levels occurred more frequently in nonsmokers (33% vs. 100%). the results are supposed to reflect subclinical stages of disease, but they are not yet of a definite predictive value. reduction ... | 1990 | 2197493 |
| [serological diagnosis of pulmonary aspergillosis--measurement of igg-, igm- and iga- antibodies against aspergillus fumigatus by means of elisa]. | serological diagnosis plays an important role in the diagnosis of pulmonary aspergillosis, however, precipitation-in-gel test is neither sensitive nor quantitative. recently, several investigators have used the elisa technique for the detection of antibodies against aspergillus fumigatus and reported the usefulness of this method. in this report, we measured igg-, igm-, and iga- antibody titers against aspergillus fumigatus by means of elisa in sera from patients with several different lung dise ... | 1990 | 2198374 |
| [the biological characteristics of micromycetes isolated from fish roe]. | the fungi aspergillus fumigatus fres., and fusarium sporotrichiella bilai were studied for their effect on certain biochemical indices of two-year carp and spawn of grass carp under laboratory conditions. the intraperitoneal introduction of a. fumigatus in a dose of 5 and 20 min conidia per individual to two-year carp decreased significantly the protein level in blood serum, the decrease being more considerable with the introduction of the smaller dose of fungal conidia. joint incubation of the ... | 1990 | 2198439 |
| use of immunoblotting to detect aspergillus fumigatus antigen in sera and urines of rats with experimental invasive aspergillosis. | immunoblotting was used to detect aspergillus fumigatus antigen in sera and urines of immunosuppressed rats experimentally infected with a. fumigatus. organisms were administered by both intravenous and intratracheal injections. intravenously infected rats developed disseminated aspergillosis, but intratracheally infected rats developed pulmonary disease only. fungal cultures of blood and urine samples from infected rats were negative. in the urines of intravenously infected rats, antigen was de ... | 1990 | 2199519 |
| carotid-cavernous sinus thrombosis caused by aspergillus fumigatus: magnetic resonance imaging with pathologic correlation--a case report. | the authors describe a case of aspergillosis with carotid-cavernous sinus thrombosis diagnosed by use of magnetic resonance imaging (mri). mri may aid in early detection of intracranial fungal infection and potentially help decrease morbidity and mortality through the institution of early medical and surgical therapy. | 1990 | 2202234 |
| pulmonary aspergillosis in mice: treatment with a new triazole sch39304. | the triazole sch39304 was compared with amphotericin b and fluconazole for the treatment of pulmonary aspergillosis in corticoid-immunosuppressed mice intranasally challenged with 5 x 10(6) conidia of aspergillus fumigatus. in vitro, the minimum inhibitory concentration (mic) for fluconazole was greater than 80 micrograms/ml, for sch39304 40 micrograms/ml, and for amphotericin b 0.29 micrograms/ml. beginning 1 day after challenge, groups of 10 mice were treated orally, twice daily, for 15 days w ... | 1990 | 2202244 |
| isolation of trichophyton verrucosum from soil in cattle breeding environments. | | 1990 | 2202846 |
| controlled trial of natamycin in the treatment of allergic bronchopulmonary aspergillosis. | allergic bronchopulmonary aspergillosis often requires treatment with oral corticosteroids to control the host response to aspergillus fumigatus. in a double blind study 25 patients with allergic bronchopulmonary aspergillosis taking maintenance oral corticosteroids were randomly allocated to receive 5 mg natamycin or placebo by nebuliser twice daily for one year. the primary aim of the study was to assess the steroid sparing potential of natamycin. standardised reductions in corticosteroid dosa ... | 1990 | 2203181 |
| in vivo efficacy of sm-8668 (sch 39304), a new oral triazole antifungal agent. | sm-8668 (sch 39304) is a new oral antifungal agent which we evaluated in comparison with fluconazole in various fungal infection models. the prophylactic effect of sm-8668 was excellent against systemic candidiasis, aspergillosis, and cryptococcosis in mice. the 50% effective dose for sm-8668 was assessed at 10 days after infection and was 0.18, 3.7, and 5.9 mg/kg (body weight), respectively, for the above-mentioned fungal diseases. fluconazole was about four times less effective than sm-8668 ag ... | 1990 | 2203310 |
| identification and partial characterization of diagnostically relevant antigens of aspergillus fumigatus. | metabolic antigens of aspergillus fumigatus, soil strain 2605 and sputum isolate, were evaluated for their diagnostic applicability using hyperimmune sera and sera of adults and pediatric patients of allergic bronchopulmonary aspergillosis. an indirect elisa was standardised by using 2-10 micrograms/ml of coating antigen for detection of specific igg and ige antibodies in the sera of patients. the ratios of absorbance for specific ige and igg antibodies by elisa (normal to patients) were observe ... | 1990 | 2203361 |
| intra-arterial and intramammary injection of miconazole for bovine mastitis caused by aspergillus fumigatus. | | 1990 | 2204467 |
| pulmonary cavitation with nocardia and aspergillus in a renal transplant patient. | we present an autopsy case of concomitant pulmonary aspergillosis and nocardiosis undiagnosed during life in a long-term surviving renal transplant recipient. the patient had fever and a newly developed cavitary lesion on a chest x-ray. the working diagnosis was pulmonary tuberculosis with possible colonization by aspergillus species. cultures of bronchial washings became positive for aspergillus fumigatus 1 day after death. the study of tissue from the lung cavity at autopsy revealed aspergillu ... | 1990 | 2204711 |
| [alveolitis caused by furnishing a medical office]. | this article reports on the occurrence of an exogenous-allergic alveolitis that developed in a colleague who moved into new consulting rooms and an apartment. the diagnosis was established on the basis of typical x-ray picture, typical pulmonary function test findings, typical bal and the histological findings established in transbronchial pulmonary biopsy material. the putative cause was moulds, the source of which could not be completely identified. in the history of an exogenous-allergic alve ... | 1990 | 2204917 |
| [cutaneous manifestation of fungal infection]. | a 50-year-old patient with an aplastic syndrome developed disseminated purpuric, necrotic lesions on his skin. histological examination revealed fungal sepsis. the clinical appearance, the course of the disease are described and the importance of histological examination is pointed out. | 1990 | 2205604 |
| effect of stereochemistry at the c-17 position on the antifungal activity of pradimicin a. | | 1990 | 2211352 |
| aspergillus fumigatus complement inhibitor: production, characterization, and purification by hydrophobic interaction and thin-layer chromatography. | aspergillus fumigatus has previously been shown to produce a soluble extracellular inhibitor of the alternative complement pathway, called aspergillus complement inhibitor, or ci. we now report an efficient method for production of ci which relies on the fact that poorly conidiating cultures yielded ci activity with approximately sevenfold-higher potency than ci produced by conidiating cultures. ci from poorly conidiating cultures provided 50% inhibition of alternative pathway-mediated binding o ... | 1990 | 2228221 |
| detection of aspergillus antigens associated with invasive infection. | serial urine samples were collected from 33 neutropenic patients, 10 of whom developed invasive aspergillosis (ia) while undergoing bone marrow transplantation or remission induction therapy for leukemia. concentrated urine samples from the infected patients were subjected to polyacrylamide gel electrophoresis, blotted, and then incubated with antiserum raised to a cell wall extract of aspergillus fumigatus (anti-cw) or an immunoglobulin g monoclonal antibody to a. fumigatus galactomannan (eba1) ... | 1990 | 2229387 |
| immunoblot analysis of sera from patients with allergic bronchopulmonary aspergillosis: correlation with disease activity. | immunoblot analysis was used to evaluate the igg, ige, and iga responses to aspergillus fumigatus antigen with the sera of five patients with allergic bronchopulmonary aspergillosis (abpa) before, during, and after suspected exacerbation of their disease. the results revealed a heterogenous antibody response, unique for each patient, to specific aspergillus fumigatus antigens that correlated with the molecular weights of previously well-characterized antigens of importance in the immunopathogene ... | 1990 | 2229814 |
| allergens as proteases: an aspergillus fumigatus proteinase directly induces human epithelial cell detachment. | allergic bronchopulmonary aspergillosis (abpa) is characterized by pulmonary and systemic allergic and inflammatory processes triggered by fungal antigens. airway damage is a feature of this disorder, and although aspergillus-derived proteinases have been described, the capacity of aspergillus, however, to directly induce damage to human epithelium has not previously been studied. we therefore cultured aspergillus fumigatus from two patients with abpa, extracted mycelial products by sonication a ... | 1990 | 2229838 |
| serum immunoglobulins e and g anti-aspergillus fumigatus antibody in patients with cystic fibrosis who have allergic bronchopulmonary aspergillosis. | patients with cystic fibrosis frequently have pulmonary colonization with aspergillus fumigatus (af) and develop anti-af immunoglobulin e (ige) and igg antibodies. the diagnosis of allergic bronchopulmonary aspergillosis in subjects with cystic fibrosis is difficult because of the high incidence of af colonization, with development of humoral antibody responses. in this study, we sequentially measured serum anti-af ige (af-e) and igg (af-g) antibodies by elisa in subjects with cystic fibrosis. i ... | 1990 | 2230542 |
| aspergillus fumigatus allergen i, a major ige-binding protein, is a member of the mitogillin family of cytotoxins. | a major 18-kd ige-binding protein from aspergillus fumigatus (asp fi) has been purified. partial amino acid sequencing of asp f i showed extensive sequence homology (95%) between asp fi and a cytotoxin (mitogillin) produced by a. restrictus. crossinhibition radioimmunoassay using murine monoclonal antibody and human igg and ige antibodies showed that asp fi and mitogillin were antigenically indistinguishable. furthermore, both proteins inhibited protein synthesis in vitro by greater than 90%. as ... | 1990 | 2230656 |
| computer automated structure evaluation of antifungal 1-vinylimidazoles, 1,2-disubstituted propenones, and azolylpropanolones. | the computer automated structure evaluation (case) program has been applied to a series of 1-vinylimidazoles, 1,2-disubstituted propenones, and azolylpropanolones exhibiting in vitro antifungal properties. relevant molecular fragments were obtained for activity against the fungal strains candida albicans, aspergillus fumigatus, and trichophyton asteroides. fragments were utilized as descriptors to derive quantitative structure-activity relationships (qsar) within each respective biological endpo ... | 1990 | 2231337 |
| [williams-campbell syndrome complicated by multiple meniscus signs in an adult case; is it a characteristic finding?]. | a 49-year-old woman visited our hospital for further examination of abnormal lung shadows in september 1984. she had suffered from pneumonia at the age of 3 years and had been treated for bronchial asthma until the age of 15. many thin-wall cystic shadows were seen on her chest x-ray film in 1983. in july 1984, a mass-like lesion with a meniscus sign appeared in one of the cystic shadows. the number and the size of similar lesions increased with worsening of productive cough. an infiltrative sha ... | 1990 | 2232375 |
| [in vitro antifungal activity of mercurobutol]. | mercurobutol, in its commercial form, exhibits fungistatic and fungicidal activities against both yeasts: candida albicans, c. tropicalis, torulopsis glabrata, pityrosporum spp., and filamentous fungi: dermatophytes, aspergillus fumigatus, mainly saprophytic or potentially pathogenic fungi of the cutaneo-mucous flora. minimal inhibitory concentrations on this antiseptic indicate a high susceptibility of the species tested, that could justify the enlargement of the indication of the drug to the c ... | 1990 | 2235087 |
| computerized tomography in the evaluation of allergic bronchopulmonary aspergillosis. | allergic bronchopulmonary aspergillosis (abpa) is a destructive disease of the lung characteristically associated with central bronchiectasis. this study was designed to determine if high-resolution computerized tomography (ct) could be used to define bronchiectasis in patients with suspected disease. sixteen patients with asthma were studied. all demonstrated immediate cutaneous reactivity to common aeroallergens including aspergillus fumigatus. eight patients had clinical and immunologic evide ... | 1990 | 2240844 |
| [successful drug therapy in aspergillus endocarditis]. | a 74-year-old man who had a weight loss of 7 kg in three months, with fever up to 38 degrees c and anaemia (hb 9.4 g/dl) began to have pain and blue discoloration of fingers ii-v of the right hand. echocardiography demonstrated vegetation on the aortic valve cusps and blood culture grew aspergillus fumigatus, indicating aspergillus endocarditis. there were no predisposing factors. valve replacement was contraindicated because of the age of the patient, the presence of peripheral arterial disease ... | 1990 | 2245766 |
| a murine model for the study of the impact of aspergillus fumigatus inoculation on the foeto-placental unit. | pregnant female balb/c mice were inoculated intravenously with aspergillus fumigatus conidia in different concentrations (1 x 10(1)-1 x 10(8)) on day 10 of pregnancy. pregnancy was confirmed by the presence of murine alpha-fetoprotein (m-afp) in the maternal circulation. conidia inoculation of 1 x 10(3) and greater significantly (p less than 0.0001) resulted in abortion or placental lesions. uterine cell infiltrations were recognized in 75% of the mice which aborted following the inoculation of ... | 1990 | 2250688 |
| evaluation of basidiomycete and deuteromycete (fungi imperfecti) extracts for shared allergenic determinants. | aqueous extracts of select members of the basidiomycetes and deuteromycetes (fungi imperfecti) were evaluated for the presence of shared allergenic determinants using skin prick and radio-allergosorbent test (rast) inhibition. twenty adults with perennial symptoms of rhinitis, with or without asthma, were skin-prick tested with six species of deuteromycetes and seven species of basidomycetes. positive weal-and-flare reactivity to pleurotus ostreatus was associated with alternaria alternata, fusa ... | 1990 | 2253084 |
| purification and characterisation of an extracellular serine proteinase from aspergillus fumigatus and its detection in tissue. | a serine proteinase (alp) from the culture supernate of a clinical isolate of aspergillus fumigatus was purified to virtual homogeneity at a yield of 41%. the procedure involved affinity chromatography on agarose-epsilon-amino-caproyl-d-tryptophan methyl ester. alp had an estimated mol. wt of 32 kda and the pi was determined at ph 7.9. the enzyme was fully inhibited by phenylmethyl sulphonyl fluoride, chymostatin and alpha-1-proteinase inhibitor, and it was largely inhibited by alpha-1-anti-chym ... | 1990 | 2258912 |
| inhibition and killing of fungi by the polyamine oxidase-polyamine system. antifungal activity of the pao-polyamine system. | both components of the polyamine oxidase (pao)-polyamine system are known to be present in phagocytes and have thus been postulated to contribute to the antimicrobial activity of these cells. therefore, the effects of the pao-polyamine system on three medically important opportunistic fungi were examined. yeasts of cryptococcus neoformans, but not candida albicans blastoconidia or aspergillus fumigatus conidia, were efficiently killed by the system. two putative end products of the system, hydro ... | 1990 | 2264722 |
| a case of occupational allergic bronchopulmonary aspergillosis unique to japan. | a 15-year-old female was diagnosed in 1980 as having allergic bronchopulmonary aspergillosis (abpa) due to aspergillus fumigatus based on rosenberg and patterson's criteria for the disease. the patient is the eldest daughter of a family of domestic brewers of soy sauce and bean paste in a small village, an occupation unique to japan. the brewing process involved the use of aspergillus oryzae as a fermenting agent. the patient had experienced episodic wheezing and pulmonary infiltrates during the ... | 1990 | 2282302 |
| biochemical mode of action and enantiomeric selectivity of sdz 89-485, a new triazole antimycotic. | sdz 89-485, a new triazole antimycotic agent, potently inhibited ergosterol biosynthesis in cells of candida. trichophyton and aspergillus. biosynthesis was measured both by incorporation of radiolabelled acetate and also by methylation of the sterol side chain. inhibition was accompanied by accumulation of radiolabel in 4,4-dimethylsterols and to a lesser extent in the 4-methylsterols, consistent with inhibition of lanosterol 14-demethylation. no other steps were affected. ergosterol biosynthes ... | 1990 | 2283585 |
| amikacin plus piperacillin versus ceftazidime as initial therapy in granulocytopenic patients with presumed bacteremia. | 69 febrile granulocytopenic episodes without an initial focus of infection were assessed for empiric treatment either with high-dose amikacin plus piperacillin or ceftazidime. 90% of patients in each group survived the granulocytopenic episode; 15 (44 +/- 17%) episodes treated with the combination and 23 (66 +/- 16%) given ceftazidime responded without any modification of initial therapy and half defervesced within 72 h. persistent fever was the most frequent reason for altering treatment which ... | 1990 | 2284577 |
| short-term curative treatment of aspergillus fumigatus pneumonia with fluconazole. | a 67-year-old previously healthy female presented with fever, malaise and bilateral pulmonary infiltrates. serology and culture were positive for aspergillus fumigatus. after 15 days of treatment with fluconazole, clinical cure and regression of the infiltrates were obtained. no side-effects were observed during or after treatment. | 1990 | 2284583 |
| [allergenicity of the osmophilic fungus aspergillus restrictus evaluated by skin prick test and radioallergosorbent test]. | recently large amounts of aspergillus restrictus, a species of osmophilic fungi, have been detected in house dust using culture media with low water activity. but little attention has been paid to this fungus as an allergen. in the present study, the authors examined the allergenic activity of a. restrictus by skin prick tests and radioallergosorbent tests (rast) on 94 asthmatic patients (mean age 12.0, range 3-18). aspergillus fumigatus, alternaria alternata and house dust were used for compari ... | 1990 | 2288495 |
| [a case of aspergillus empyema with bronchopleural fistula]. | pleural aspergillosis is not a common disease and we recently experienced a case of aspergillus empyema with bronchopleural fistula. a 76 year-old man was admitted to our hospital with productive cough and fever. chest x-ray films showed infiltration in the right lower and left middle field and rather lucent area (clearing) in the right lower lung. antibiotic therapy was administered but no improvement was obtained. chest ct scan and right bronchography revealed empyema in the right back portion ... | 1990 | 2290234 |
| respiratory atopy in rio de janeiro. | an epidemiologic study was conducted in rio de janeiro, brazil, evaluating 1,410 patients with asthma and/or rhinitis. allergy skin testing was performed in 1,219 patients (intradermal and/or multi-test lincoln diagnostics techniques). thirteen different allergens were tested: house dust, dermatophagoides farinae, grasses, alternaria tenuis, hormodendrum hordei, penicillium mix, aspergillus fumigatus, dogs, cats, feathers, fleas, cockroaches, and household insects. the most frequent positive imm ... | 1990 | 2306018 |
| aspergillosis in gentoo penguins (pygoscelis papua) at edinburgh zoo, 1964 to 1988. | aspergillosis was the commonest cause of death in gentoo penguins (pygoscelis papua) at edinburgh zoo from 1964 to 1988. chicks were the most susceptible group and 14 per cent of hatched birds died of the disease (47 per cent of post mortem diagnoses) although in two years no cases were recorded and in two other years there were outbreaks which killed more than 50 per cent of the birds hatched. there was no correlation between the size of the colony and the prevalence of the disease but the clim ... | 1990 | 2309389 |
| serum igg antibody concentrations against environmental microbes in mares and foals during different seasons and effect of stabling practices. | over periods of 22 and 14 months, igg antibody concentrations in serum samples obtained monthly from 14 mares and 19 foals, respectively, were measured by use of elisa against antigens of the following environmental microbes: aspergillus umbrosus, penicillium brevicompactum, rhodotorula glutinis, absidia corymbifera, aspergillus fumigatus, humicola grisea, micropolyspora faeni, and thermoactinomyces vulgaris. the mares and foals were on pasture from early june until early october, then were stab ... | 1990 | 2327613 |
| fungi of the house dust in riyadh, saudi arabia. | 30 species belonging to 18 genera were isolated from floor dust of 30 homes in riyadh. out of them 16 species and 10 genera were isolated from dust of air conditioners of the same homes. the most common genera in floor dust were aspergillus, penicillium and cladosporium. aspergillus repens, a. amstelodami, a. versicolor, a. fumigatus, penicillium purpurogenum, p. crustosum, cladosporium cladosporoides and c. herbarum were frequently isolated. the most abundant genera in air conditioner dust were ... | 1990 | 2330766 |
| intracranial aspergillus granuloma simulating meningioma on mr imaging. | a case of intracranial granuloma caused by aspergillus fumigatus involving the anterior cranial fossa is reported. the patient was nonimmuno-compromised and was asymptomatic until he had an accident. the magnetic resonance appearance simulated a meningioma, showed isointense mass with brain parenchyma on both t1- and t2-weighted images with pial vascular rim. the final diagnosis was established after surgery and histopathological examination. | 1990 | 2335619 |
| evaluation of nikkomycins x and z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis. | nikkomycins x and z, competitive inhibitors of fungal chitin synthase, were evaluated as therapeutic agents in vitro and in mouse models of coccidioidomycosis, histoplasmosis, and blastomycosis. in vitro, the nikkomycins were found to be most effective against the highly chitinous, dimorphic fungi coccidioides immitis and blastomyces dermatitidis, were less effective against yeasts, and were virtually without effect on the filamentous fungus aspergillus fumigatus. additionally, by transmission e ... | 1990 | 2344165 |
| studies on the mycoflora of aswan high dam lake, egypt: monthly variations. | fifty-one species and one variety appertaining to twenty one genera of mesophilic fungi were recovered from the monthly samples of marginal water (44 species, 1 variety and 18 genera) and submerged mud (78 species, 1 variety and 30 genera) of aswan high dam lake during the period from july 1985 to december 1986. the most common species were aspergillus fumigatus, a. flavus, a. terreus, a. niger and penicillium funiculosum. the highest fungal populations were almost detected either in october, in ... | 1990 | 2352135 |
| [serologic studies in the diagnosis of pneumonia]. | the importance of serological determination procedures for the diagnosis of pathogens was investigated in 207 episodes of pneumonia. the pathogenic organisms were detected in 138 cases; in 40 cases serological analysis helped to establish the diagnosis, while in 11 cases of pneumonia, the diagnosis was possible only with serology. the organisms most commonly found by serological investigations were cytomegalovirus (n = 10), aspergillus fumigatus (n = 7), and the influenza b virus (n = 7). multip ... | 1990 | 2367358 |
| [pneumonia in patients with and without immunosuppression--value of bronchoscopic biopsy technics for the detection of pathogens]. | bronchoscopic diagnosis was performed in 91 patients with 100 episodes of fresh pneumonia. in already existing immunosuppression (n = 51, group a) pathogens were most frequently identified via bronchoalveolar lavage (70%); in patients without immunosuppression (n = 49, group b) the identification quota in respect of the central bronchial secretion (53%) and bronchoalveolar lavage (47%) were comparable. in group a the most frequently occurring pathogens were pneumocysti carinii (n = 18) and asper ... | 1990 | 2367437 |
| [iga antibodies in exogenous allergic alveolitis are more specific than igg antibodies]. | nineteen sera from patients suffering from extrinsic allergic alveolitis (bird fancier's lung, farmer's lung) and 19 sera from asymptomatic persons demonstrating igg-antibodies were examined for iga-antibodies against pigeon serum, micropolyspora faeni and aspergillus fumigatus. the iga-antibodies against pigeon serum and micropolyspora faeni were less of ten false-positive than the corresponding igg-antibodies. hence the iga-antibodies were more specific than the igg-antibodies. however, the se ... | 1990 | 2367456 |
| studies on the mycoflora of aswan high dam lake, egypt: vertical fluctuations. | the fungal population of aswan high dam lake showed marked vertical variations during the period of study which extended from july 1985 to december 1986. high fungal counts were observed at the surface water which were mainly due to the high counts of aspergillus fumigatus and a. terreus. going deeper the fungal population decreased till 30 meters, then gradually increased to reach its maximum at the 70 meter depth (near the bottom of the lake). such increase was basically due to the high popula ... | 1990 | 2370640 |
| spontaneous pneumothorax complicating pulmonary mycetoma in patients with acute leukemia. | pneumothorax caused by the rupture of a mycetoma into the pleural space is rarely reported in patients undergoing intensive cytotoxic therapy for hematologic malignancies. we reviewed 46 episodes of mycetoma that developed in 43 patients undergoing antineoplastic therapy; six (13%) of these episodes were further complicated by the occurrence of pneumothorax that developed after bone marrow recovery with return to normal granulocyte count. etiologic agents included aspergillus fumigatus, aspergil ... | 1990 | 2385767 |
| isolation of fungi from local bread of chhindwara. | in the present paper, fungi isolated from bread samples are being reported. out of 150 samples of bread, only 20 samples appeared to be infected but when cultured all the samples could not give positive results, except, a. fumigatus. ten fungi including aspergillus fumigatus, a. niger, a. flavus, a. glaucous, a. carnous, a. terreus, a. ochraceous, rhizophus stolonifer, trichoderma harrianua, and trichothecium roseum were recovered from the bread samples. among these a. fumigatus and a. niger wer ... | 1990 | 2391152 |
| correlation of ige antibody titer to aspergillus fumigatus with decreased lung function in cystic fibrosis. | obstructive pulmonary disease is a typical feature of cystic fibrosis (cf) and is often associated with bronchial hyperreactivity. positive skin-test reactions to aspergillus fumigatus antigens are frequently seen even in nonatopic patients with cf. full-fledged allergic bronchopulmonary aspergillosis (abpa) has been estimated to occur in 10% of patients with cf. the relationship between lung function and presence of ige antibodies to aspergillus antigens in patients without abpa is not clear. i ... | 1990 | 2405341 |
| human neutrophil degranulation stimulated by aspergillus fumigatus. | previous studies have established that human neutrophils (pmn) are unable to kill resting conidia (rc) of aspergillus fumigatus but can kill conidia that have been preincubated in culture medium until swollen but not yet germinated. compared with swollen conidia (sc), rc stimulate a relatively weak pmn respiratory burst. in the present study, we further examined the mechanisms of resistance of rc to neutrophil killing by comparing neutrophil degranulation and phagocytosis following stimulation b ... | 1990 | 2406356 |
| disseminated aspergillosis presenting as a skin abscess. | an immunocompromised patient presented with chronic low back pain as the initial symptom and a subcutaneous abscess as the initial sign of disseminated aspergillosis. with the rising incidence of immunocompromised patients, cutaneous manifestation of aspergillosis may become more common. | 1990 | 2407390 |
| detection of antigens in lung biopsies by immunoperoxidase staining in extrinsic allergic bronchiolo-alveolitis (eaba). | open lung biopsy specimens of 14 patients with extrinsic allergic bronchiolo-alveolitis (eaba) were studied by immunoperoxidase staining with avidin-biotin-complex method using nonconjugated antisera to micropolyspora faeni, thermoactinomyces vulgaris, aspergillus fumigatus, and aspergillus umbrosus. antigenic intracellular material was found in macrophages and giant cells of granulomas in the lung tissue of 8 patients. this finding supports the hypothesis which suggests that macrophages and t-l ... | 1985 | 2409726 |
| identification of an agent in cultures of aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro. | when cultured in vitro, aspergillus fumigatus generated a metabolite(s) with anti-phagocytic activity as tested by macrophage adherence to plastic and phagocytosis of particulate matter. the metabolite(s) appeared after 3 d culture and reached a peak concentration after 5-6 d. the action of the anti-phagocytic agent(s) was rapid (5-15 min) and appeared not to alter membrane permeability or cause rapid cell death. treatment of stimulator spleen cells with the agent(s) inhibited their ability to i ... | 1985 | 2410548 |
| a rapid colorimetric assay of fungal viability with the tetrazolium salt mtt. | a rapid colorimetric assay for viability of fungi that uses the tetrazolium salt mtt is described. all live species of a wide range of medically important fungi that were tested reduced mtt, with resultant intracellular formation within several hours of clearly visible purple crystals of mtt-formazan. the assay proved particularly useful in measuring viability of individual hyphae; greater than 99% of live aspergillus fumigatus and rhizopus oryzae hyphae stained purple when incubated with mtt co ... | 1985 | 2413145 |
| bronchial allergy in cystic fibrosis. | thirty-one patients with cystic fibrosis (cf) were thoroughly evaluated for allergy. this included a clinical history, skin tests with twenty-three allergens and bronchial provocation with inhaled allergens and histamine. the bronchial response was measured by whole body plethysmography. of the patients studied, 40% showed a bronchoconstrictor response to inhaled allergens, despite the fact that none had reported asthma in their clinical history. strong skin test reactions (3+ and 4+) and weak r ... | 1985 | 2414033 |
| a partially purified glycoprotein antigen from aspergillus fumigatus. | culture filtrate antigens of aspergillus fumigatus were fractionated by isoelectric focusing using a ph gradient of 4-6.5. three fractions, namely, 18, 19 and 20 were pooled and subjected to immunochemical analysis. it contained a concanavalin a binding glycoprotein. antibody raised against this component was used to prepare an affinity column of igg-sepharose and was used to purify crude culture filtrate antigens. this component produced three precipitin arcs in crossed immunoelectrophoresis us ... | 1986 | 2419255 |
| evaluation of cross-reactions in histoplasma capsulatum serologic tests. | cross-reactivity in histoplasma serologic tests was evaluated by using sera from patients with histoplasmosis and other infections. serum samples from 127 of 134 (95%) patients with histoplasmosis were judged positive by complement fixation tests, and 121 (90%) showed h bands, m bands, or both by immunodiffusion. of these 134 patients, cross-reactions were seen to blastomyces dermatitidis in 53 patients (40%), to coccidioides immitis in 20 patients (16%), and to aspergillus fumigatus in 3 patien ... | 1986 | 2420821 |
| studies on bronchial hyperreactivity, allergic responsiveness, and asthma in rural and urban children of the highlands of papua new guinea. | the prevalence of asthma and allergic responsiveness in rural and urban children of the highlands of papua new guinea was studied. bronchial provocation studies with histamine demonstrated significant bronchial hyperreactivity in 0.5% (1 in 195) rural and 1.7% (1 in 59) urban children, rates which were significantly lower than those observed in corresponding adult populations (7%). urban children demonstrated a higher incidence of skin test reactivity toward dermatophagoides pteronyssinus, asper ... | 1986 | 2420852 |
| cross-reactive polysaccharides from trypanosoma cruzi and fungi (especially dactylium dendroides). | cross-reactivity between fungal and trypanosoma cruzi polysaccharides, owing to common residues of beta-d-galactofuranose, beta-d-galactopyranose, and alpha-d-mannopyranose, was demonstrated by using rabbit immune sera against t. cruzi epimastigotes and sera from patients with chagas' disease. several chagasic (ch) sera precipitated partly purified galactomannans from aspergillus fumigatus and from t. cruzi epimastigotes and also the galactoglucomannan from dactylium dendroides. reaction of one ... | 1986 | 2426444 |
| [development, symptomatology and treatment of "animal" and "plant" parasites of the central nervous system]. | eight cases of today rather rare infections of the brain and spinal cord with animal and plant parasites are described. echinococcus was identified in one patient, cysticercus cellulosis in 4 and in 3 patients various fungi (actinomycosis meyerii, aspergillus fumigatus, nokardiose asteroides) were found. prior to the admission to the hospital none of these patients were correctly diagnosed. animal parasites mimicked the symptomatology of a brain tumour or of a space occupying process. if localis ... | 1986 | 2428102 |
| the effect of gliotoxin upon macrophage function. | gliotoxin, a metabolite of the fungus aspergillus fumigatus, inhibited phagocytosis of particulate matter by rodent macrophages. in addition, adherence to plastic surfaces by peritoneal and alveolar rodent macrophages, human peripheral blood monocytes, mouse secondary fibroblasts and l929 cells was differentially inhibited by gliotoxin. electron microscopy which confirmed the inhibition by gliotoxin of phagocytosis of carbon particles by rodent macrophages also revealed gliotoxin-induced morphol ... | 1986 | 2430903 |
| incidence of keratinophilic fungi in rice-field soils. | soil samples from rice-fields, collected at monthly intervals, were analysed by baiting technique for the incidence of keratinophilic fungi. nine species, among a total of 102 species isolated by various methods, were keratinophilic species (8.8%). these were recorded from 38 out of 45 samples collected. the distribution pattern of the different keratinophilic fungi and their significance are discussed. | 1987 | 2436049 |
| possible confusion of aspergillus fumigatus and pneumocystis carinii. | | 1987 | 2449349 |
| localization, molecular weight and immunoglobulin subclass response to aspergillus fumigatus allergens in acute bronchopulmonary aspergillosis. | a specimen of aspergillus fumigatus was isolated from a patient with acute bronchopulmonary aspergillosis (abpa). cultures were allowed to propagate and were separated into spores and mycelium to greater than 95% homogeneity. extracts of both the spores and mycelium were prepared and used for study by both dot blot analysis and immunoblotting to study the major allergens. by dot blot analysis, 22 of 22 patients with abpa and none of 10 healthy controls reacted with mycelium when probed for both ... | 1988 | 2451644 |
| interferon inhibits aspergillus fumigatus growth in mice: an activity against an extracellular infection. | prophylactic treatment of mice with interferon (ifn) or polyinosinic-polycytidylic acid [poly(i:c)], an ifn inducer, provided significant protection against an extracellular infection by aspergillus fumigatus in both swiss and swiss athymic nude mice. tunicamycin (tm) treatment inhibits the antifungal activity of ifn and poly(i:c) in these mice. anti-asialo gm1 or tm [both inhibitors of natural killer (nk) cell function] treatment enhance the severity of a. fumigatus infection. these results sug ... | 1988 | 2452848 |
| histopathology of experimental aspergillus fumigatus keratitis. | histopathological studies in rabbit's eyes, 7 and 14 days after intracorneal inoculation with 1 x 10(5) aspergillus fumigatus conidia have been performed. similar lesions were found in both periods with fungal hyphae in the anterior third of corneal stroma, round cell infiltration from the sclero-corneal edge and in the anterior chamber and, neovascularization. no lesions were found in the descemet's membrane. gomori silver-methenamine stain with hematoxiline-eosine counter-stain was found to be ... | 1988 | 2454404 |
| the application of immunoperoxidase staining for the detection of causative fungi in tissue specimens of mycosis i. | this study was performed in order to identify the fungi of four species (aspergillus fumigatus, fusarium anthophilum, candida albicans, cryptococcus neoformans) in formalin-fixed, paraffin-embedded tissue sections by the indirect method of immunoperoxidase staining. mature albino rabbits were immunized by formalin-killed organisms. the antibodies were prepared by precipitation at a 50% saturation of ammonium sulfate and were checked for cross-reactivities by ouchterlony's double immunodiffusion ... | 1988 | 2457159 |
| ecological and physiological studies on fungi associated with human hair. | thirty-seven species attributed to 19 genera of keratinophilic fungi were recovered from 100 human hair samples collected from the assiut governorate. the genera aspergillus followed by penicillium and chrysosporium were frequently isolated from 65, 43 and 30% of the samples respectively. fifteen species and 13 genera of thermophilic and thermotolerant fungi (recovered at 45 degrees c) were identified. the thermotolerant aspergillus fumigatus was frequently encountered and emerged from 82% of th ... | 1988 | 2462534 |
| immunoblot fingerprinting aspergillus fumigatus. | a new technique for typing aspergillus fumigatus is presented. this is based on immunoblot fingerprinting each isolate against a rabbit hyperimmune antiserum raised against a. fumigatus nctc 2109. all isolates were typable and reproducibility for the 16 antigenic bands which formed the basis of the system was excellent. discrimination was better than silver staining and revealed 11 types among the 21 isolates from eight patients with an aspergilloma. each aspergilloma could be due to either a si ... | 1989 | 2466902 |
| [effect of temperature and moisture in feed on the growth of aspergillus fumigatus and the formation of gliotoxin]. | | 1987 | 2471040 |
| isolation of a mycotoxin (gliotoxin) from a bovine udder infected with aspergillus fumigatus. | a bovine udder infected with aspergillus fumigatus was analysed by physico-chemical methods (thin layer chromatography, high performance liquid chromatography and direct exposure probe-mass spectrometry) for the presence of mycotoxins. gliotoxin, a fungal metabolite with cytotoxic and immunosuppressive properties was isolated for the first time from naturally infected tissue. the gliotoxin concentration analysed (9.2 mg kg-1 udder) was approximately 100 times higher than the concentration known ... | 1989 | 2474066 |
| [effect of the components of the medium on aspergillus fumigatus growth and its formation of gliotoxin]. | | 1986 | 2478869 |
| use of thin layer chromatography for detection and high performance liquid chromatography for quantitating gliotoxin from rice cultures of aspergillus fumigatus fresenius. | gliotoxin, a mycotoxin with antimicrobial and immunosuppressive capabilities, is produced by several genera of fungi including the pathogenic fungus aspergillus fumigatus. the ability of selected isolates of a. fumigatus to produce gliotoxin on three different media was tested and a thin layer chromatographic and high performance liquid chromatographic method for quantitation of gliotoxin from rice culture was developed and is described. rice cultures were extracted with chloroform and the resul ... | 1989 | 2482445 |
| intratracheal exposure of rats to aspergillus fumigatus spores isolated from sawmills in sweden. | five strains of aspergillus fumigatus (a, b, d, h, and k) isolated from sawmills were used to expose groups of three rats by intratracheal intubation. the dose was 10(9) spores per rat. at 48 h after administration, two rats from the d group and all rats from the k group died with symptoms of strong dyspnea and tachypnea. at 72 h postadministration and after, some animals showed mild to moderate dyspnea and tachypnea. autopsies of all animals were performed, including a histopathological examina ... | 1989 | 2483040 |
| [in vitro study of the antifungal activity of two chlorine derivatives to be used in antisepsis]. | the activity of two chlorine derivates, sodium hypochlorite in water solution with nacl (product a) and electrolytic chloroxidant (product b) has been tested in vitro against potentially human pathogenic fungi (aspergillus niger, aspergillus fumigatus, microsporum gypseum, candida albicans, cryptococcus neoformans, trichophyton mentagrophytes, microsporum canis, epidermophyton floccosum, trichophyton rubrum, sporotrix schenkii). for a. niger, the relation of the two compounds has also been consi ... | 1989 | 2483652 |
| incorporation of tellurium into amino acids and proteins in a tellurium-tolerant fungi. | aspergillus fumigatus, aspergillus terreus, and penicillium chrysogenum, a tellurium tolerant fungi, are able to grow on sulfur free medium amended with 0.2% (w/v) tellurite. tellurium was incorporated into several types of low and high molecular weight proteins. the newly detected telluro-proteins contained an extraordinary high level of tellurium, as well as telluro-cysteine, telluro-cystine, telluro-methionine, and serine. | 1989 | 2484755 |
| isolation of human pathogenic fungi from barbers' shop of chhindwara (mp): a preliminary study. | isolation of human pathogenic fungi was made from the barbers' shops of chhindwara. trichophyton mentagrophytes showed highest percentage of occurrence (30%), followed by trichophyton rubrum (26%) and aspergillus fumigatus (18%) whereas, the lowest relative density was exhibited by aspergillus niger and a hyphomycetous fungus (2%). | 1989 | 2486270 |
| neuropathology of pediatric liver transplantation. | we reviewed the clinical histories and autopsy records of 35 pediatric patients (ranging in age from 9 months to 18 years) who underwent orthotopic liver transplantation using ciclosporin and corticosteroids for immunosuppression. at the time of death, 19 children (54%) had encephalopathy, 16 (46%) were lethargic or in coma, 10 (29%) had seizures, and 10 were normal. neuropathological lesions were found on postmortem examination in all 35 patients. vascular lesions such as infarction, ischemia, ... | 1989 | 2489584 |
| aspergillus infection in the neutropenic host. | | 1989 | 2498353 |
| increased amounts of the aspergillus metabolite d-mannitol in tissue and serum of rats with experimental aspergillosis. | several aspergillus species produce large amounts of the hexitol d-mannitol in vitro, but it is not known whether these species also produce d-mannitol in vivo. serum samples and homogenized tissues were analyzed from rats pretreated with cortisone and cyclophosphamide and then given 2 x 10(6) preincubated conidia of aspergillus fumigatus intravenously. the resulting infection was lethal by 48 h and was characterized by much more severe disease in the liver than in the kidneys, spleen, or lungs. ... | 1989 | 2499640 |
| efficacy of immunoprecipitation methods for rapid serodiagnosis of allergic bronchopulmonary aspergillosis. | the relative efficacy of ouchterlony's double diffusion (odd), wadsworth's gel diffusion (wgd) and counter-immunoelectrophoresis (cie) is reported for serodiagnosis of allergic bronchopulmonary aspergillosis (abpa). of the 50 sera taken from patients with confirmed or suspected abpa, serum precipitins were demonstrated against aspergillus fumigatus by cie, wgd and odd in sera from 34, 31 and 25 patients, respectively. the results were negative by the three methods in sera taken from 10 healthy v ... | 1989 | 2499786 |
| ct findings in sphenoid sinus aspergillosis. | | 1989 | 2501737 |
| indolinone derivatives as potential antimicrobial agents. | 1-substituted aminomethyl-3-cyclohexylthiosemicarbazone-2-indolinones (i) were tested for their antibacterial activity against bacillus pumilis, bacillus brevis and bacillus megaterium and antifungal activity against aspergillus flavus, aspergillus fumigatus and aspergillus niger. the majority of the compounds were found to exhibit promising antibacterial and antifungal activities. these compounds were also screened for their antiviral action against tobacco mosaic virus in nicotiana glutinosa p ... | 1989 | 2501946 |
| the radiographic appearances of infection and acute rejection of the lung after heart-lung transplantation. | thirty-two patients underwent combined heart and lung transplantation at papworth hospital between 1984 and 1987. the clinical and physiologic observations made at the time of episodes of infection and rejection together with the histopathology of lung tissue obtained by transbronchial lung biopsy were compared with pre- and postepisode chest radiographs. there were 45 episodes of rejection in 20 patients: 23 episodes during the first month after transplantation, and 22 after 1 month. twenty-six ... | 1989 | 2502057 |
| aspergillosis. | aspergillus spores are ubiquitous in the environment and may become concentrated in hospital ventilation systems. colonization in normal hosts can lead to allergic diseases ranging from asthma to allergic bronchopulmonary aspergillosis. normal hosts rarely develop invasive disease, which is primarily an infection of severely immunocompromised patients. the major predisposing factors for infection include prolonged neutropenia, chronic administration of adrenal corticosteroids, the insertion of p ... | 1989 | 2502407 |
| immunofluorescence staining of hyphae in the histopathological diagnosis of mycoses in cattle. | an immunofluorescence staining system was developed for the identification of mycelial fungi causing systemic mycoses in cattle. antisera to absidia corymbifera, aspergillus fumigatus, aspergillus flavus, and aspergillus niger were raised in rabbits. tissue sections of experimentally infected mice were used to determine the specificity of immune staining with antisera that had been absorbed with heterologous antigens. when 46 lesions from 22 cattle with systemic mycosis were studied, the infecti ... | 1989 | 2502614 |
| biocidal activity of ozone versus formaldehyde against poultry pathogens inoculated in a prototype setter. | ozone was evaluated as an alternative hatchery disinfectant to replace formaldehyde in the event that the environmental protection agency regulates the use of formaldehyde under the toxic substances control act. cultures of staphylococcus, streptococcus, and bacillus species previously isolated from poultry hatcheries and selected culture collections of escherichia coli, pseudomonas fluorescences, salmonella typhimurium, proteus species, and aspergillus fumigatus were spread-plated on open petri ... | 1989 | 2506541 |
| pulmonary and myocardial infarction secondary to arterial occlusion by aspergillus fumigatus in anll. | secondary invasive aspergillosis is a well-recognized complication of the immunocompromised patient. this case concerned a 52-y.o. male patient affected by anll (fab: m2). on day 10 after induction therapy the patient, previously apyretic and asymptomatic, had an episode of acute dyspnea with fever (39 degrees c). chest x-ray and pulmonary scintigram were compatible with a diagnosis of pulmonary embolism, and the patient was started on heparin. on day 24 the patient had persistent anginal pain w ... | 1989 | 2511122 |
| comparison of immunodiffusion and enzyme linked immunosorbent assay for antibodies to four aspergillus species. | antigenic extracts were prepared from aspergillus fumigatus, a niger, a flavus and a terreus for use in enzyme linked immunosorbent assay (elisa) and immunodiffusion (id) tests for aspergillus antibodies to determine whether the use of antigenic extracts from species other than a fumigatus increased the sensitivity of the elisa. elisa titres correlated well with positive id tests. patient titres by elisa were significantly higher than control titres for all species. patient titres to a niger wer ... | 1989 | 2511230 |
| modulation of anti-candida activity of human alveolar macrophages by interferon-gamma or interleukin-1-alpha. | the fungicidal and bactericidal activities of human alveolar macrophages (am) and peripheral blood monocytes (pbm) from 18 healthy volunteers were evaluated. the results showed that am were able to phagocytize and kill candida albicans, pseudomonas aeruginosa, and staphylococcus aureus. however, killing of the bacteria was already complete in 2 h, whereas killing of candida required 4 to 6 h despite an early phagocytosis of yeast cells. the fungicidal activity of freshly collected am and pbm was ... | 1989 | 2516451 |
| evaluation of the specificity of pasteurella multocida somatic antigen-typing antisera prepared in chickens, using ribosome-lipopolysaccharide complexes as inocula. | purified lipopolysaccharides (lps) from 16 serotypes of pasteurella multocida were complexed with aspergillus fumigatus ribosomes. the complexes were used as inocula to prepare antisera, in chickens, for somatic antigen typing by the gel diffusion precipitin test (gdpt). antisera made against 15 of 16 lps reacted with their respective specific heat-stable antigens in the gdpt and homologous lps in the passive hemagglutination test. antisera could not be made against serotype 15 lps. correlation ... | 1989 | 2521991 |
| posterior ischemic optic neuropathy due to aspergillus fumigatus. | a 35-year-old woman with metastatic breast cancer experienced acute monocular visual loss. her fundus examination was normal. the patient died 48 h later, and autopsy demonstrated hematogenously disseminated aspergillosis. the retrobulbar optic nerve of the affected eye showed infarction due to massive embolization with aspergillus fumigatus. although the retrobulbar optic nerve is relatively resistant to ischemia, its meningeal derived blood supply may be occluded by massive showers of emboli. | 1989 | 2522950 |
| in vitro t cell responses in patients with cystic fibrosis and allergic bronchopulmonary aspergillosis. | allergic bronchopulmonary aspergillosis (abpa) occurs as a complication in patients with cystic fibrosis (cf). previous studies of the immunopathogenesis of abpa have indicated that b cells (igg and ige antibodies to aspergillus fumigatus), t cells, and eosinophils are components of the disease. to evaluate t-cell regulation, we examined in vitro immune responses in seven patients with cf and abpa compared with subjects who had a positive reaction to an a. fumigatus (af) prick skin test, an igg ... | 1989 | 2522977 |
| lymphocyte sensitization to aspergillus fumigatus in allergic bronchopulmonary aspergillosis. | peripheral blood mononuclear cell (pbmc) proliferation induced by an extract of aspergillus fumigatus (af) was examined in patients with allergic bronchopulmonary aspergillosis (abpa), all of whom had an immediate skin prick test reaction (spt) and increased rast binding to af, and, for comparison, in individuals without immediate spt reactivity or increased rast binding to af. the proliferative responses of pbmc from the abpa patients were greater than those from the comparison donors. a substa ... | 1989 | 2525438 |
| structural analysis of water-soluble fractions obtained from aspergillus fumigatus mycelium. | fractions were prepared from the water-soluble components of aspergillus fumigatus mycelium either by lectin-affinity chromatography or salt precipitation. while they varied considerably in their amino-acid composition, each contained a preponderance of aspartic and glutamic acids. 13c-nmr spectroscopy of these fractions, compared with that of polysaccharide obtained by alkaline extraction, indicated the presence of glycoproteins, the polysaccharide components of which contained beta-d-galf unit ... | 1989 | 2535480 |
| in vitro studies with dimethyldithiocarbamate, possible new antimicrobial for use in poultry. | tests were conducted to determine the in vitro efficacy of the dithiocarbamate analogue, dimethyldithiocarbamate (dmdtc), against selected poultry pathogens. organisms studied were two bacteria, pasteurella multocida and escherichia coli, and a mold, aspergillus fumigatus. zone of inhibition and the minimum inhibitory concentration were determined for each organism. dmdtc was effective in vitro against all organisms tested, with a. fumigatus showing greatest overall sensitivity. | 1989 | 2539077 |
| [in vitro activity of fluconazole, a novel bistriazole antifungal agent]. | fluconazole is a novel triazole antifungal agent with excellent activities against a broad range of medically important fungi. the in vitro antifungal activities of fluconazole especially against candida albicans were examined and the results summarized as follows: 1. fluconazole was proved to exhibit the highest antifungal activity in synthetic amino-acid medium, fungal (saamf), well buffered in a physiologically neutral range. 2. in a exposed time-killing test performed using saamf (ph 7.4), t ... | 1989 | 2540356 |