| studies on immunological tolerance to lcm virus. 9. induction of immunological tolerance to the virus in the adult mouse. | | 1968 | 4970125 |
| a new method for the titration of lymphocytic choriomeningitis viruses. | | 1967 | 4970514 |
| biophysical and biochemical characterization of lymphocytic choriomeningitis virus. 3. thermal and ultrasonic sensitivity. | | 1967 | 4970518 |
| [studies on the virus of lymphocytic choriomeningitis. i. stabilization of the virus]. | | 1968 | 4971398 |
| an anti-lcm agent from propionibacteria. | | 1968 | 4976432 |
| inhibition of lymphocytic choriomeningitis virus replication by actinomycin d and 6-azauridine. | | 1969 | 4976538 |
| on the induction of immunological tolerance to a self-reproducing antigen. | | 1969 | 4977003 |
| meningitis due to lymphocytic choriomeningitis virus endemic in a hamster colony. | | 1969 | 4977735 |
| antibody formation in persistent tolerant infection with lymphocytic choriomeningitis virus. | | 1969 | 4977740 |
| dose-response relationships of lymphocytic choriomeningitis viruses in mice and l cell tube cultures. | | 1969 | 4978938 |
| rejection of skin grafts from mice chronically infected with lymphocytic choriomeningitis virus by non-infected syngeneic recipients. | | 1969 | 4979144 |
| nonhuman primates in viral research. | | 1969 | 4979566 |
| experimental infection with the virus of lymphocytic choriomeningitis of x-ray-irradiated mice. | | 1967 | 4980364 |
| morphological comparison of machupo with lymphocytic choriomeningitis virus: basis for a new taxonomic group. | striking morphologic similarities between machupo, tacaribe, and lymphocytic choriomeningitis viruses were found by thin-section electron microscopy. it is proposed that these viruses be brought together into a single taxonomic group. | 1969 | 4980850 |
| arterial lesions in gnotobiotic mice congenitally infected with lcm virus. | | 1969 | 4981015 |
| immunoproliferative effects of lymphocytic choriomeningitis virus in germfree mice. | | 1969 | 4981173 |
| complement-fixing antigen from bhk-21 cell cultures infected with lymphocytic choriomeningitis virus. | infection of bhk-21 cells with lymphocytic choriomeningitis (lcm) virus resulted in the production of significant titers of complement-fixing (cf) antigen. the antigen was spontaneously released from the cells, but the highest titer of 1:16 was recovered by disruption of the infected cells by freeze-thawing in tryptose phosphate broth. the antigen could be partially separated from infectious virus by centrifugation. furthermore, it was possible to detect lcm virus infection of cell cultures by t ... | 1969 | 4984767 |
| immunological tolerance and the significance of cell-mediated immunity in virus infections. | | 1969 | 4985045 |
| serological relationship of the tacaribe complex of viruses to lymphocytic choriomeningitis virus. | by means of the indirect fluorescent-antibody test, cross serological reactivity was demonstrated between lymphocytic choriomeningitis (lcm) virus and the viruses of the tacaribe complex. antisera to all members of the tacaribe complex reacted with lcm virus; lcm antisera gave significant staining of amapari virus, but minimal or inconsistent reactions with tacaribe virus, and no reaction with two other viruses of the tacaribe complex. a low level cross-reaction was observed in complement fixati ... | 1970 | 4985595 |
| [radiation effects on benign lymphocytic choriomeningitis virus]. | | 1968 | 4986168 |
| morphological and cytochemical studies on lymphocytic choriomeningitis virus. | lymphocytic choriomeningitis (lcm) virus was observed by electron microscopy in thin sections of infected tissue cultures. the particles were pleomorphic and varied greatly in size. the smaller particles (50 to 200 nm) appeared to be spherical, whereas the largest (over 200 nm) were often cup-shaped. all particles contained one to eight or more electron-dense granules which were removed by ribonuclease. the particles were formed by budding from the plasma membrane and appeared to have spikes. th ... | 1968 | 4986483 |
| the effect of immunosuppressive therapy of the murine lymphocytic choriomeningitis virus infection. | | 1969 | 4986549 |
| effect of antilymphocyte serum on adoptive immunization of lymphocytic choriomeningitis virus carrier mice. | | 1969 | 4986554 |
| observations on mice infected congenitally or neonatally with lymphocytic choriomeningitis (lcm) virus. | | 1970 | 4986679 |
| arenoviruses: proposed name for a newly defined virus group. | the name "arenoviruses" is proposed for the newly defined taxonomic group containing lymphocytic choriomeningitis, lassa, and the tacaribe complex viruses. | 1970 | 4986852 |
| plaque assay for lymphocytic choriomeningitis virus based on hemadsorption interference. | | 1967 | 4987174 |
| reproducible plaquing system for rabies, lymphocytic choriomeningitis,k and other ribonucleic acid viruses in bhk-21-13s agarose suspensions. | bhk21/13s-agarose suspension cultures provide an excellent plaquing system for rabies and lymphocytic choriomeningitis viruses. the system has facilitated accurate and reproducible assay of serum neutralization and cloning of these viruses. rubella, reo, and kern canyon viruses may also be assayed by this technique. | 1967 | 4987176 |
| lassa fever, a new virus disease of man from west africa. iv. electron microscopy of vero cell cultures infected with lassa virus. | | 1970 | 4987548 |
| [latent infection of the syrian hamster (mesocricetus auratus auratus) with lymphocytic choriomeningitis virus (lcm)]. | | 1968 | 4987918 |
| lcm virus as a carrier of non-viral cellular components. electron microscopic evidence. | | 1970 | 4988085 |
| [the infection rate of the rural population in the federal republic of germany with the lymphocytic choriomeningitis virus]. | | 1970 | 4989309 |
| observations with a variant of lymphocytic choriomeningitis virus in mouse tumors. | | 1970 | 4989547 |
| lymphocytic choriomeningitis in the mouse. 3. comparative titrations of virus strains in inbred mice. | | 1969 | 4989712 |
| the response of mice to the intravenous injection of lymphocytic choriomeningitis virus. | | 1970 | 4990517 |
| reduced interferon response in mice congenitally infected with lymphocytic choriomeningitis virus. | | 1970 | 4991742 |
| ultrastructural pathology of glomerular lesions in gnotobiotic mice with congenital lymphocytic choriomeningitis (lcm) virus infection. | | 1970 | 4991777 |
| tissue injury in lymphocytic choriomeningitis viral infection: virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells. | | 1970 | 4992354 |
| cerebellar hypoplasia in neonatal rats caused by lymphocytic choriomeningitis virus. | lymphocytic choriomeningitis virus, strain e-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. several other arenoviruses may produce a similar lesion in neonatal rodents. | 1971 | 4992415 |
| the sensitivity of the human diploid cell strain wi-38 to different viruses. | | 1970 | 4992901 |
| density gradient centrifugation studies on lymphocytic choriomeningitis virus and on viral ribonucleic acid. | lymphocytic choriomeningitis (lcm) virus, traub strain, was purified from bhk-21 tissue culture medium. the virus was then analyzed by equilibrium centrifugation and rate zonal centrifugation in sucrose gradients. a buoyant density in sucrose of 1.18 g/ml was found and the s(20, w) value was estimated to be about 470 to 500s. furthermore, the (3)h-uridine-labeled ribonucleic acid (rna) from virus was extracted from lcm virus and analyzed by rate zonal centrifugation. two major and one minor sing ... | 1970 | 4993891 |
| virus, cell surface, and self: lymphocytic choriomeningitis of mice. | | 1971 | 4999326 |
| the effects of mp virus infection in lymphoma. | | 1971 | 4999485 |
| [a powerful and simply-prepared complement fixing antigen for lymphocytic choriomeningitis virus]. | | 1968 | 4999689 |
| initiation of persistent lymphocytic choriomeningitis infection in adult mice. | | 1971 | 4999906 |
| characterization of virus-specific antigen in cell culture infected with lymphocytic choriomeningitis virus. | | 1971 | 5000793 |
| effect of serum on the yield of lymphocytic choriomeningitis virus in baby hamster kidney cells. | the yields of the armstrong and we strains of lymphocytic choriomeningitis virus in baby hamster kidney (bhk) cells cultivated in either bovine, calf, fetal bovine, or horse serum were investigated. lines of bhk cells were established in these sera. when the infected cell lines were observed by immunofluorescence, the per cent fluorescing cells for a given virus strain did not vary. however, for both strains, the extracellular virus yields per cell were significantly greater in the fetal bovine- ... | 1971 | 5000864 |
| monitoring mouse stocks for lymphocytic chloriomeningitis virus--a human pathogen. | | 1971 | 5001340 |
| amantadine hydrochloride inhibition of early and late stages of lymphocytic choriomenigitis virus-cell interactions. | | 1971 | 5001514 |
| lymphocytic choriomeningitis virus rnas. | | 1971 | 5002277 |
| the contamination of laboratory animals with lymphocytic choriomeningitis virus. | | 1971 | 5002469 |
| animal model: congenital and persistent lcm infection. | | 1972 | 5033263 |
| interaction of bordetella pertussis vaccine treatment and lymphocyte choriomeningitis virus infection in mice. | | 1972 | 5076340 |
| [antigenic relationships in the arenavirus group. i. results obtained by the complement fixation test]. | | 1972 | 5077032 |
| phytohemagglutinin-induced dna synthesis in blood lymphocytes from mice persistently infected with the virus of lymphocytic choriomeningitis. brief report. | | 1971 | 5088185 |
| autoimmunity and viruses--fact or fiction: persistent lcm viral infection, anti-lcm viral immune response, and tissue injury. | | 1971 | 5094495 |
| lytic and turbid plaque-type mutants of lymphocytic choriomeningitis virus as a cause of neurological disease or persistent infection. | mouse-passaged lymphocytic choriomeningitis (lcm) virus was found to contain a mixture of two different plaque-type mutants when plated on bhk-21/13s cells in agarose suspension. one mutant gave rise to clear plaques, with death of the cells, whereas the other produced turbid plaques which were sometimes very difficult to see. the clear-plaque variant caused a pronounced cytopathic effect on bhk-21 cells, but the turbid variant caused none; it also interfered with the cytopathic effect due to th ... | 1971 | 5154886 |
| effect of actinomycin d on the yield of lymphocytic choriomeningitis virus in baby hamster kidney cells. | depending on the concentration of actinomycin d, the yield of lymphocytic choriomeningitis virus in baby hamster kidney cells was either enhanced or inhibited. | 1971 | 5170547 |
| immunofluorescence study of the carrier state and mechanism of vertical transmission in lymphocytic choriomeningitis virus infection in mice. | | 1966 | 5331383 |
| immunofluorescence study of the mechanism of resistance to superinfection in mice carrying the lymphocytic choriomeningitis virus. | | 1966 | 5331384 |
| the course of lymphocytic choriomeningitis virus infection in mice treated by phytohaemagglutinin. | | 1969 | 5365879 |
| enhanced resistance to arboviruses of mice with persistent lymphocytic choriomeningitis virus infection. | | 1969 | 5369328 |
| mother-infant interaction in lymphocytic choriomeningitis virus infection of the newborn mouse: the effect of maternal health on mortality of offspring. | | 1970 | 5419336 |
| [the distribution of infection with the virus of lymphocytic choriomengitis among the population of the federal german republic]. | | 1970 | 5462798 |
| arenoviruses in vero cells: ultrastructural studies. | thin-section electron microscopy was carried out on vero green monkey kidney cell cultures infected with some viruses of the newly constituted arenovirus group. junin, machupo, amapari, pichinde, parana, tamiami, and latino viruses were morphologically identical and indistinguishable from lymphocytic choriomeningitis virus, the prototype virus of the group. virus particles were round, oval, or pleomorphic, 60 to 280 nm in diameter, and matured via budding from plasma membranes. most characterist ... | 1970 | 5497898 |
| an antiviral substance in the tissues of mice acutely infected with lymphocytic choriomeningitis virus. | | 1971 | 5542487 |
| congenital lymphocytic choriomeningitis virus infection in gnotobiotic mice. | | 1968 | 5651129 |
| [lymphocytic choriomeningitis in the form of lethargic encephalitis]. | | 1968 | 5652784 |
| the immunodepressive action of lymphocytic choriomeningitis virus in mice. | | 1968 | 5681651 |
| thymus-dependent lymphocytes: destruction by lymphocytic choriomeningitis virus. | selective destruction of small lymphocytes in the thymusdependent areas of lymph nodes and thymocytes was observed in mice infected with lymphocytic choriomeningitis virus. these changes were clearly evident in lymphoid and splenic tissue 3 days after infection and in the thymus by day 7. the destructive changes paralleled growth of the virus in these organs. the findings show that infection with lymphocytic choriomeningitis virus can temporarily cause the equivalent effect of neonatal thymectom ... | 1969 | 5765339 |
| development of humoral and cell-mediated immunity to lymphocytic choriomeningitis virus in the mouse. | | 1969 | 5768197 |
| the detection of neutralizing antibody to lymphocytic choriomeningitis virus in mice. | | 1969 | 5770437 |
| [postencephalitic parkinsonism and the problem of sporadic lethargic encephalitis (v. economo)]. | | 1969 | 5780725 |
| [sensitivity of white mice to lymphocytic choriomeningitis virus according to age]. | | 1969 | 5795678 |
| [spread of the lymphocytic choriomeningitis virus among west german mice. i. investigations mostly on domestic mice (mus musculus)]. | | 1964 | 5831628 |
| [on the spread of lymphocytic choriomeningitis virus among mice in west germany. ii. studies of mice except mus musculus]. | | 1964 | 5831889 |
| detection of a lymphocytic choriomeningitis component in rabies virus preparations. | | 1965 | 5848338 |
| [sero-epidemiologic investigation of antibodies to the lymphocytic choriomeningitis virus in children]. | | 1965 | 5856788 |
| role of the central nervous system in fatal murine lymphocytic choriomeningitis. (brief report). | | 1965 | 5882950 |
| lymphocytic choriomeningitis. | | 1966 | 5907690 |
| interference between lymphocytic choriomeningitis and rauscher leukemia in mice. | | 1966 | 5923905 |
| epidemic nonmeningitic lymphocytic-choriomeningitis-virus infection. an outbreak in a population of laboratory personnel. | | 1966 | 5948615 |
| lymphocytic choriomeningitis virus. viii. reciprocal formation of pseudotypes with vesicular stomatitis virus. | large numbers of vsv (lcmv) pseudotypes with the genomes of vesicular stomatitis virus (vsv) and the coat proteins of lymphocytic choriomeningitis virus (lcmv) were produced by infecting l cells first with lcmv and subsequently with vsv, the latter in the presence of tunicamycin. separation by gradient centrifugation from the concomitantly produced lcmv genotypes, followed by polyacrylamide gel electrophoresis (page), failed to reveal measurable quantities of the one glycoprotein ("g") of vsv. b ... | 1984 | 6089420 |
| the immune response of the mouse to lymphocytic choriomeningitis virus. iv. enumeration of antibody-producing cells in spleens during acute and persistent infection. | the solid-phase immunoenzymatic technique for the enumeration of single rat cells producing antibodies against ovalbumin has been adapted to mouse cells producing antibodies against lymphocytic choriomeningitis (lcm) virus. after intravenous (i.v.) infection with 10(3) infectious units, igm- and igg-producing cells appeared on days 4 and 5, respectively. they rose to high numbers on days 7, 8, and 9 and were still detectable on day 38. after a second i.v. inoculation of 10(7) infectious units, a ... | 1984 | 6092472 |
| augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo. | conventional and nude mice inoculated with syngeneic or allogenic tumor cells developed a rapid rise in serum interferon (if) levels, peaking within 24 h. within the same period, natural killer (nk) activity was readily boosted in the spleen. both activities usually declined at 3 d. cells that lacked the ability to augment nk activity also failed to induce detectable levels of if. the boosting of if and nk functions did not appear to be a result of contamination of the tumor lines by viruses bec ... | 1980 | 6154760 |
| natural killer cell response to lymphocytic choriomeningitis virus in beige mice. | lymphocytic choriomeningitis virus (lcmv) induced low levels of natural killer (nk) cell acitivity in c57bl6 mutant beige (bg/bg) mice, which had previously been reported to have no cytotoxic nk cells. nk cell-mediated lysis by bg/bg splenocytes was observed against a cell line (yac-1) very sensitive to nk cell cytotoxicity, but not appreciably against a less sensitive cell line (l-929). the bg/bg mutant mice with this very low nk cell activity and control strains of mice (by/+, c57bl6) with hig ... | 1980 | 6155687 |
| a comparative analysis of the cell surface properties of activated vs endogenous mouse natural killer cells. | mouse natural killer (nk) cells can be activated by interferon and by interferon inducers, such as viruses. in the present report we compared the cell surface properties of the nonactivated "endogenous" nk cells from normal mice with nk cells activated in vivo by acute infection with lymphocytic choriomeningitis virus (lcmv) or in vitro by interferon. several striking differences were found: 1) in vivo lcmv-activated as well as in vitro interferon-activated nk cells were more adherent to nylon w ... | 1980 | 6157740 |
| severity of lymphocytic choriomeningitis virus disease in different strains of suckling mice correlates with increasing amounts of endogenous interferon. | a marked difference was observed in the severity of disease in lymphocytic choriomeningitis (lcm) virus-infected suckling balb/c, swiss, and c3h mice. balb/c mice had minimal liver lesions and none died, whereas c3h mice had extensive liver lesions and all mice died. an intermediate pattern was oberved for swiss mice (36% mortality). although there was no difference in the titers of lcm virus in the plasma or liver between these three strains of mice, there was a marked difference in the amount ... | 1980 | 6157772 |
| cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice: natural killer cell activity in cultured spleen leukocytes concomitant with t-cell-dependent immune interferon production. | the characteristics and specificities of spleen and peritoneal cytotoxic cells generated during lymphocytic choriomeningitis virus (lcmv) infection of c3h/st mice were examined. activated natural killer (nk) cell activity was identified in fresh leukocyte populations from the 2nd to 8th days postinfection, whereas virus-specific cytotoxic t-cell activity was detected from the 6th to 14th days. when leukocytes were cultured overnight at 37 degrees c before assay, t-cell activity was still observe ... | 1980 | 6160108 |
| monoclonal antibodies to lymphocytic choriomeningitis virus react with pathogenic arenaviruses. | certain arenaviruses have become widely recognized as important human pathogens, the most notable among these being lassa virus, the causative agent of lassa fever. two other members of the group, junin and machupo virus, are the aetiological agents of argentine and bolivian haemorrhagic fevers, respectively. all these agents share both morphological features and to varying degrees serological cross-reactivity with other non-pathogenic arenaviruses. despite the evident clinical importance of the ... | 1980 | 6160402 |
| concanavalin a-mediated in vitro activation of a secondary cytotoxic t-cell response in virus-primed splenocytes. | in a recent report it was shown that what appeared to be secondary cytotoxic t cells could be obtained from lymphocytic choriomeningitis virus (lcmv)-primed splenocytes after stimulation in vitro with the non-specific t cell mitogen concanavalin a (con a). the present experiments attempt to characterize further these effector cells and, in particular, to establish whether the con a-activated cytotoxic effectors are qualitatively different from the secondary cytotoxic t cells induced by restimula ... | 1980 | 6160612 |
| the virology and immunobiology of lymphocytic choriomeningitis virus infection. | | 1980 | 6160740 |
| interferon-induced disease in mice and rats. | treatment of newborn mice with potent mouse interferon preparations resulted in an acute "early" syndrome characterized by inhibition of growth, delay in maturation of several organs, diffuse liver cell necrosis and death. when interferon treatment was discontinued at 1 week of life, mice appeared to recover, but subsequently developed a progressive glomerulonephritis ("late syndrome"). treatment of newborn rats with potent rat interferon preparations also resulted in inhibition of growth, delay ... | 1980 | 6165266 |
| interferon induction by lymphocytic choriomeningitis viruses correlates with maximum virulence. | lymphocytic choriomeningitis (lcm) viruses isolated from the blood of persistently infected mice, could be clearly divided into two categories by observing the disease patterns they produced after intracerebral (i.c.) injection in a number of adult inbred and outbred mice. one type (aggressive) caused the classic pattern of convulsive death in 100% of the mice 7 to 9 days after infection, while the other (docile) caused a protracted disease with deaths occurring, if at all, 2 to 4 weeks after in ... | 1981 | 6172554 |
| differential lysis of endogenous and activated natural killer cells by anti-nk-1.2 antibody and complement. | | 1982 | 6173440 |
| chronic production of interferon in carrier mice congenitally infected with lymphocytic choriomeningitis virus. | | 1982 | 6175085 |
| [seroepidemiology of infections by coxsackie group b virus, types 1-6, herpes simplex virus, and lymphocytic choriomeningitis virus in a population of healthy adults and children. cf reaction using dextran t 70 as an adjuvant]. | | 1981 | 6182843 |
| tubular aggregates and interferon. | | 1982 | 6183542 |
| interferon restriction of target organs for lymphocytic choriomeningitis virus-induced t lymphocytes may be lethal. | | 1982 | 6183689 |
| severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: correlation with amounts of endogenous interferon and circulating immune complexes. | renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in c3h mice which produced the highest amount of interferon. further studies could not be performed in these mice since all died by day 14. balb/c mice produced the lowest amount of interferon and had v ... | 1982 | 6184462 |
| natural killer cell activity during mouse hepatitis virus infection: response in the absence of interferon. | the ability of the jhm3 strain of mouse hepatitis virus (mhv) to induce natural killer (nk) cells was examined. infection of c57bl/6 (b6) mice with this virus resulted in the augmentation of natural cytotoxicity against yac-i target cells in the absence of a detectable interferon response. the cells responsible for this increased cytotoxicity were sensitive to complement-mediated lysis with an anti-q-5 reagent but not with a thy 1.2 antiserum, indicating that they possess an nk-like surface phen ... | 1983 | 6186617 |