| thermodynamics of the denaturation of pepsinogen by urea. | the denaturation of swine pepsinogen has been studied as a function of urea concentration, ph, and temperature. the unfolding of the protein by urea has been found to be fully reversible under different conditions of ph, temperature, and denaturant concentration. kinetic experiments have shown that the transition shows two-state behavior at 25 degrees c in the ph range 6-8 covered in this study. analysis of the equilibrium data obtained at 25 degrees c according to tanford (tanford, c. (1970), ... | 1978 | 23143 |
| interaction of steroids with d-amino acid oxidase. | 1. progesterone inhibited d-amino acid oxidase (d-amino acid : o2 oxidoreductase (deaminating), ec 1.4.3.3) in competition with its substrate, d-alanine. binding of progesterone brought about the increase in both fluorescence intensity and fluorescence polarization of fad, which indicates that the environment surrounding fad chromophore is modified due to a conformational change in the apoenzyme. 2. ethinyl estradiol, testosterone, testosterone propionate, corticosterone and aldosterone also inh ... | 1978 | 23164 |
| the beta-adrenoceptor stimulant properties of opc-2009 on guinea-pig isolated tracheal, right atrial and left atrial preparations. | 1. the beta-adrenoceptor stimulant properties of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxy-carbostyril hydrochloride hemihydrate (opc-2009) were compared with those of isoprenaline and salbutamol on guinea-pig isolated tissues. 2. in producing tracheal relaxation, opc-2009 was approximately 7 times more potent and salbutamol 5 times less potent than isoprenaline. both compounds were less potent than isoprenaline in increasing either the rate of beating of isolated right atria or the contract ... | 1977 | 23191 |
| a comparative study of the distribution of free choline in the plasma, liver, lung and kidney of the toad, tortoise, chicken and guinea-pig. | | 1977 | 23239 |
| an nmr study of a tyrosine and two histidine residues in the structure of porcine pancreatic colipase. | | 1978 | 23316 |
| characterization and development of cimetidine as a histamine h2-receptor antagonist. | the concept of two classes of histamine receptor, h1 and h2, is introduced and the chemical derivation of histamine h2-receptor antagonists is outlined briefly. starting from the structure of histamine, chemical modification led eventually to burimamide, the first described histamine h2-receptor antagonist. further stepwise modifications ultimately afforded metiamide and cimetidine. in vitro studies show that cimetidine is a specific competitive histamine h2-receptor antagonist. in vivo, it is a ... | 1978 | 23336 |
| determination of porcine blood creatine kinase by firefly luciferase. | | 1977 | 23374 |
| further evidence for adrenergic transmission in the human vas deferens. | 1. isolated portions of human vas deferens responded to field stimulation of the intramural nerve fibres or to exogenously applied noradrenaline with rhythmical contractions of both longitudinal and circular muscle layers. 2. in guinea-pig and rabbit vas deferens field stimulation produced an initial rapid 'twitch' response which was not found with human vasa. 3. responses of the human vas to field stimulation were depressed by the alpha-adrenoceptor blocking agents phentolamine and yohimbine. 4 ... | 1977 | 23430 |
| analysis of the beta-receptor mediated effect on fast-contracting skeletal muscle in vitro. | subtetanic contractions of the isolated extensor digitorum longus (edl) of the guinea-pig, a fast-contracting muscle, were evoked by transmural field stimulation. isoprenaline, adrenaline, terbutaline, and noradrenaline each caused a dose-dependent increase in the force of contraction, their potencies decreasing in that order. tyramine was without effect in this respect. curare depressed the contractions of edl by about 20% but did not appreciably change the response to the beta-adrenoceptor ago ... | 1977 | 23500 |
| acid and pepsin secretion in young pigs reared solely by the sow or supplemented with solid food and weaned at 21 d. | | 1977 | 23539 |
| molecular mechanism of active calcium transport by sarcoplasmic reticulum. | | 1978 | 23557 |
| development of adrenal medullary function in swine. | | 1978 | 23683 |
| influence of consecutive, physically exhaustive motor stress on domestic pigs and on the quality of pork. | | 1977 | 23739 |
| methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme. | methylenetetrahydrofolate dehydrogenase (5,10-methylenetetrahydrofolate: nadp+ oxidoreductase, ec 1.5.1.5) one of the activities of a trifunctional folate-dependent enzyme from porcine liver, uses an ordered kinetic mechannism as determined from initial velocity, product inhibition and dead-end inhibition studies. the final product released from the dehydrogenase is methenyltetrahydrofolate. however, from the time course of appearance of products it is observed that the methenyltetrahydrofolate, ... | 1978 | 23838 |
| purification and properties of 4-aminobutyrate 2-ketoglutarate aminotransferase from pig liver. | 4-aminobutyrate-transaminase (4-aminobutyrate: 2-oxoglutarate amino-transferase, ec 2.6.1.19) from pig liver has been purified to electrophoretic homogeneity. it has a molecular weight of about 110 000 and is composed of two subunits of the same molecular weight but of different charges. two forms of pig liver 4-aminobutyrate-transaminase were isolated by deae-cellulose chromatography and designated as 4-aminobutyrate-transaminase i and 4-aminobutyrate-transaminase ii, corresponding to a cationi ... | 1978 | 23842 |
| an in vitro comparison of beta-adrenoceptor stimulants on potassium-depolarized uterine preparations from guinea-pigs. | 1 a comparison of six beta-adrenoceptor stimulants has been carried out on in vitro preparations of guinea-pig uterus which were depolarized in k(+)-krebs solution. results have also been obtained on uterine preparations in which contractions to acetylcholine were inhibited. the establishment of the conditions for the k(+)-depolarized preparations are described.2 there was no significant difference between potency values (mean neg log ec(50) values) for any of the drugs on the two types of uteri ... | 1978 | 23882 |
| the syntheses and beta-adrenoceptor activities of n-substituted 2-amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols. | | 1977 | 23906 |
| syntheses and beta-adrenoceptor activities of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. | | 1977 | 23907 |
| glucokinase and hexokinase in pig erythrocytes. | we have shown different enzymatic activities responsible for the phosphorylation of glucose in pig erythrocytes. these activities were observed after partial purification from hemolyzed red cells. one of the enzymes involved is the hexokinase which is present in all tissues; the other is similar to hepatic glucokinase. we have determined the kinetic properties of these activities in hemolysates and in partially purified preparations. their electrophoretic-migration characteristics were studied t ... | 1978 | 23945 |
| the contribution of metabolism to the hypothermia-induced supersensitivity of guinea-pig isolated atria; selective supersensitivity for beta-adrenoceptor agonists and their positive inotropic responses. | | 1977 | 23978 |
| induction of ovulation and fertility in prepuberal gilts. | | 1977 | 24034 |
| virulence and resistance to superoxide, low ph and hydrogen peroxide among strains of mycobacterium tuberculosis. | six strains of mycobacterium tuberculosis of different virulence in guinea-pigs were compared with regard to their resistance to low ph, to hydrogen peroxide (h2o2) at different ph values and to superoxide (o2-). low virulence was associated with susceptibility to h2o2 in native and isoniazid-resistant strains but not in laboratory-attenuated strain h37ra. h2o2 resistance was only partly related to catalase content. low virulence was not associated with susceptibility to an acid environment but ... | 1978 | 24084 |
| lithium inhibition of the adenosine-induced increase of adenylate cyclase activity. | | 1978 | 24099 |
| gastric mucosal ulceration induced in pigs by tabelts but not suspensions or solutions of aspirin. | | 1978 | 24102 |
| a comparison of the binding constant (kd) of 125i-labelled 3-(4-iodophenoxy)-1-isopropylamino-propan-2-ol obtained on beta-adrenoceptors in guinea-pig myocardial membranes, with its dissociation constants (kb) obtained on guinea-pig isolated atria and trachea. | the dissociation constant of binding (kd) of 125i-labelled 3-(4-iodophenoxy)-1-isoproplyaminopropan-2-ol (iip) to guinea-pig myocardial membrane preparations was 2.2 x 10-8m. in pharmacological experiments with the non-labelled material and 60 min contact time, iip produced a parallel shift in the orciprenaline concentration-response line on guinea-pig isolated tracheal and atrial preparations. the dissociation constant (kb) of iip was 2.9 x 10-8m on atria (pa2 7.54) and 3.3 x 10-8m on trachea ( ... | 1978 | 24112 |
| in vitro release of leu- and met-enkephalin from the corpus striatum. | | 1978 | 24181 |
| synthesis of benzimidazole derivatives with potential antihistaminic activity. | | 1977 | 24226 |
| tissue and blood gamma-glutamyl transferase distribution in the pig. | gamma-glutamyl transferase distribution was studied in 10 pigs with an average weight of 100 kg. it was shown that kidney had the highest concentration of the enzyme, followed by pancreas, spleen and liver. blood activities measured in plasma and sera from 54 animals were very similar, ie, 35+/-21 iu/litre for plasma and 36+/-14 iu/litre for serum. | 1977 | 24241 |
| studies on glutamic-oxalacetic (got) and glutamic-pyruvic (gpt) transaminases of swine kidney worm stephanurus dentatus (diesing, 1839). i. assay and general properties. | biochemical studies on the two transaminases got and gpt of swine kidney worm stephanurus dentatus have been made. got has been found much more active than gpt. enzyme activities are based on the formation of oxaloacetate (got) or pyruvate (gpt) from aspartic acid and alanine respectively with oxoglutarate. a linear relationship is observed between the enzyme concentration and activity. got shows a maximum activity at ph 8.0 and michaelis constant 9 x 10(-3) m for male and 2.9 x 10(-3) m for fem ... | 1977 | 24309 |
| na+ transport by mammalian stomach. | gastric mucosas from newborn pigs (0--20 days) and rabbits (0--20 days) were used for in vitro investigation of active na+ transport during resting (no hcl secretion) conditions. as measured with 22na+, these tissues actively absorb na+ from the mucosal-to serosal (m-t-s) bathing solution during both open-circuit and short-circuit current (is) conditions. in the nonsecreting state, net na+ transport accounts for 40--60% of isc. the remaining current is provided by net s-to-m flux of cl-. amilori ... | 1978 | 24346 |
| electrical activity of the large intestine in normal and megacolon pigs. | | 1977 | 24404 |
| the sow in the ante and postpartum period. ii. report: activity determinations of the serum enzymes got, gpt, ldh, cpk, sdh, gldh and gamma-gt. | | 1978 | 24435 |
| constancy of the nadp-linked isocitrate dehydrogenase/transhydrogenase ratios of mitochondria of different mammalian tissues. | | 1977 | 24481 |
| relaxin, a male hormone? immunocytological localization of a related antigen in the boar testis. | convincingly demonstrated by immunocytological methods in females of several mammalian species, relaxin has not yet been localized in the male. immunocytologically, a related antigen was identified in adult normal boar testes using and anti- nih p-relaxin/hsa antiserum free of anti hsa abs. a strong reaction was observed in interstitial cells, a weaker but very clear one in sertoli cells. nih p-relaxin and hc1-acetone extracts of either corpora lutea from pregnant sows or boar testes inhibited t ... | 1978 | 24499 |
| evidence that the efficacy (intrinsic activity) of fenoterol is higher than that of salbutamol on beta-adrenoceptors in guinea-pig trachea. | the functional antagonism of carbachol by fenoterol and salbutamol (beta-adrenoceptor agonists) has been used to demonstrate that the efficacy (intrinsic activity) of fenoterol was about twice that of salbutamol on guinea-pig trachea. the mean maximum shifts of the carbachol concentration--response lines by fenoterol and salbutamol were (log units) 1.07 +/- 0.07 (n = 5) and 0.64 +/- 0.07 (n = 5) respectively. this difference in their efficacies could be demonstrated as differences in maximum rel ... | 1978 | 24543 |
| binding of thyrotropin to receptors in fat tissue. | | 1978 | 24565 |
| environment of tryptophan residues in alpha-lactalbumin. | | 1978 | 24620 |
| selective chemical modification and 19f nmr in the assignment of a pk value to the active site lysyl residue in aspartate transaminase. | | 1978 | 24633 |
| characterization of microtubule protein oligomers by analytical ultracentrifugation. | samples of microtubule protein prepared by repeated cycles of assembly-disassembly were examined at low temperatures by sedimentation velocity ultracentrifugation. sedimenting boundaries corresponding to the 6 s tubulin subunit as well as to two oligomeric species with s020,w values of 18.6 s and 30.6 s were observed. the 30 s to 6 s mass ratio varied with total protein concentration, suggesting that a concentration-dependent equilibrium exists between 6 s and oligomeric species of tubulin. a st ... | 1978 | 24642 |
| the presence of inhibitory histamine h-2-receptors in guinea-pig tracheobronchial muscle. | | 1978 | 24693 |
| the action of physalaemin on the peristaltic reflex of guinea-pig isolated ileum. | | 1978 | 24694 |
| the enterohepatic circulation of oxazepam-o-glucuronide in guinea-pigs. | | 1978 | 24695 |
| the effect of various topical antibiotic and antibacterial agents on the middle and inner ear of the guinea-pig. | the topical application of antibiotics and anti-inflammatory agents is used to reduce inflammation of the middle ear mucosa and irradicate infection. many of the antibiotic and anti-inflammatory preparations so used contain compounds known to be or are potentially ototoxic. eighteen antibiotic, antibacterial, antifungal and anti-inflammatory compounds and four commonly used solvents were screened for the absence of ototoxicity and inflammation to the middle ear mucosa. all compounds were injecte ... | 1978 | 24712 |
| fate of 14cwarfarin in guinea-pigs: effect of a concomitant single dose of salicylate. | when a single dose of sodium salicylate (177.8 mg kg-1, by mouth) was given with 14c warfarin (1 mg kg-1, i.p.) to guinea-pigs, the salicylate depressed the blood concentrations of 14c for 6 h. at 1 h, salicylate increased the distribution of 14c in the liver and brain, but at 1 and 6 h it was decreased in the blood and kidney. a significant portion of the 14c was excreted into the bile, but was subject to enterohepatic circulation and then excreted by the kidney. there was an enhancement of the ... | 1978 | 24713 |
| lh-rh (author's transl). | | 1978 | 24760 |
| interactions of neurotransmitters. | | 1978 | 24762 |
| amino acids as transmitters (glutamic acid and asparaginic acid). | | 1978 | 24763 |
| some properties of redox components of pig thyroid microsomes. | | 1977 | 24800 |
| reversible modifications of neurotransmitters of the brain in experimental acute hepatic coma. | | 1978 | 24900 |
| neuroleptic blockade of the effect of various neurotransmitter substances. | the antagonistic effect of neuroleptics to acetylcholine, histamine, 5-ht, and noradrenaline was examined in various in vivo and in vitro models. piflutixol, a new potent thioxanthene neuroleptic, markedly antagonizes the effect of dopamine, noradrenaline, 5-ht and to some extent histamine, whereas the affinity for muscarinic receptors was rather weak. clozapine and chlorprothixene on the other hand, have high affinity for muscarinic receptors and also antagonize the effect of histamine and 5-ht ... | 1978 | 24978 |
| reduced tyrosine hydroxylase activity in guinea-pig uterus during pregnancy. | | 1977 | 24979 |
| the effect of l-dopa and alpha-methyl-dopa on c cell secretion in the thyroid gland. | | 1977 | 24984 |
| experimental studies of the specificity and aspecificity of a beta-adrenolytic agent, bunitrolol (kö 1366). | in basis of our experimental researches bunitrolol presented: a) beta-adrenolytic activity prevailingly at cardiac level (superior to propranolol and practolol) in respect to vascular, tracheal, bronchial, uterus, intestinal and metabolic level; b) beta-adrenergic intrinsic activity; c) local anesthetic activity; d) chinidino-like activity; e) antiarrhythmic activity; f) hypotensive activity with interferences at the level of vasomotor centres, of the barosensitive zones, of the renin secretion ... | 1978 | 25057 |
| experimental analysis of the cardiovascular effects of acebutolol, a drug with beta-adrenolytic activity. | in experiments at cardiovascular system level, acebutolol was found to possess beta-adrenolytic activity of cardioselective type associated with intrinsic beta-adrenergic, antiarrhythmic and anti-hypertensive activity. it was well tolerated systemically. | 1978 | 25058 |
| a study of h+ transport in gastric microsomal vesicles using fluorescent probes. | fluorescent amines, 9-aminoacridine, acridine orange and quinacrine, were used as probes for a ph gradient (deltaph) across gastric microsomal vesicles. analysis of probe uptake data indicates that 9-aminoacridine distributes across the membrane as a weak base in accordance with the deltaph. on the other hand, acridine orange and quinacrine show characteristics of binding to membrane sites in addition to the accumulation in response to deltaph. a discussion of the advantages and limitations of t ... | 1978 | 25082 |
| anti-allergy properties of prd-92-ea 5,5-dimethyl-11-oxo 5h, 11h-(2) benzopyrano (4,3-g) (1) benzopyran-9-carboxylic acid ethanolamine proceedings. | | 1978 | 25105 |
| syntheses of 1,2-n-alkylimino-1,2,3,4-tetrahydronaphthalene derivatives and preparation of ring closed analog of salbutamol as a new beta-adrenoceptor agent. | | 1978 | 25142 |
| syntheses of 6-amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5h-benzocyclohepten-5-ol derivatives. | | 1978 | 25143 |
| effect of substrate composition and concentration on aortic cholesterol ester hydrolase activity. | cholesterol ester hydrolase activity of pig aorta has been examined under optimum experimental conditions for hydrolysis of different cholesterol esters. the enzyme specific activity values were in the numerical order of substrates hydrolyzed: cholesteryl linoleate larger than or equal to linolenate greater than palmitate larger than or equal to stearate greater than oleate. the results are discussed in relation to the arterial accumulation of cholesterol esters. | 1978 | 25174 |
| the order of substrate addition and product release during the catalytic action of pig-plasma benzylamine oxidase. | | 1978 | 25180 |
| neutral proteases in the guinea-pig lymphocytes. | partial purification of neutral proteolytic enzymes in guinea-pig lymphocytes yielded 2 enzymes. both enzymes were heat-labile and inhibited by thiol reagents. the molecular weights were more than 200,000 and 150,000-200,000, and optimal ph around 9 and 8, respectively. | 1978 | 25195 |
| acylation of lysophosphatidylcholine by subcellular fractions of guinea-pig cerebral cortex: subcellular distributions of acyl-coenzyme a synthetase and acyl-coenzyme a hydrolase proceedings. | | 1978 | 25208 |
| the activity of glutathione reductase in a2-cell and b-cell-rich pancreatic islets. | | 1978 | 25238 |
| stronglyoides ransomi: factors influencing the in vitro development of the free-living generation. | among the progeny of parasitic females of strongyloides ransomi, ransomi, males did not appear in significant numbers until the 7th week of infection in cases of simple infection, and until the 3rd week of infection in cases of multiple infection. the appearance of males was attributed to the effect of host immunity, the physiological ageing of the parasitic females, or both. type of culture substrate and other cultural conditions did not influence the percent of larvae developing into males. se ... | 1978 | 25317 |
| rat jugular vein relaxes to norepinephrine, phenylephrine and histamine. | circular muscle of the rat external jugular vein contracted to serotonin, angiotensin and potassium chloride but not to norepinephrine, phenylephrine, histamine or carbamylcholine. in contrast, rabbit and guinea-pig jugular veins contracted to norepinephrine, phenylephrine and histamine, although contractions to norepinephrine were small in guinea-pig jugular veins. norepinephrine, phenylephrine and histamine produced a concentration-dependent sustained relaxation of serotonin-induced contractio ... | 1978 | 25337 |
| somatostatin--paracrine and neuromodulator peptide in gut and nervous system. | somatostatin, a tetradecapeptide widely distributed in nervous tissue and gut, has inhibitory effects on secretion and neuromuscular activity. the actions of this peptide probably embrace three types of transmitter-receptor interaction, namely that of a neurotransmitter in the nervous system, that of a hormone in the hypophyseal portal circulation and that of a local (paracrine) effector in gut and pancreas. | 1978 | 25488 |
| pharmacology of beta blockaders. | | 1976 | 25566 |
| inhibition of experimental immediate hypersensitivity reactions by a novel xanthone, ru 31156. | ru 31156, the tris-(hydroxymethyl)-aminomethane salt of 7-(s-methylsulphonimidoyl)-5-(n-hexyl)-xanthen-9-one-2-carboxylic acid has been found to be a potent inhibitor of experimental immediate hypersensitivity reactions in vivo. in the ige-mediated rat pca test, ru 31156 had an ed50 of 0.0046 (00037--0.0057) mg/kg which compared to a figure of 1.21 (1.04--1.42) mg/kg for disocium cromoglycate (dscg), both compounds being administered intravenously. ru 31156 was also active when administered oral ... | 1978 | 25634 |
| synthesis and beta-adrenergic blocking activity of 1-amino-3-(1,3-dioxalan-2-ylphenyloxy) propan-2-ols and 1-amino-3-(183-dioxan-2-ylphenyloxy)-propan-2-ols (author's transl). | | 1978 | 25640 |
| h2-antihistaminics, ii: synthesis and pharmacology of alpha-substituted metiamide analogues (author's transl). | | 1978 | 25641 |
| pressure relaxation of the equilibrium of the pig heart lactate dehydrogenase system. | the relaxation behaviour of a system of reactants equilibrated in the presence of pig heart lactate dehydrogenase was studied after pressure perturbation. two relaxations were observed when protein fluorescence was recorded, but only the slower relaxation was apparent in observations of a340. the faster relaxation therefore involves transfer between free and enzyme-bound nadh, whereas the slower relaxation represents the reduction of nad+. both relaxations were observed in tris buffer, where the ... | 1978 | 25657 |
| purinergic innervation of the guinea-pig urinary bladder. | 1 a number of criteria for considering adenosine 5'-triphosphate (atp) as a neurotransmitter in the guinea-pig urinary bladder have been examined. in addition, the effect of tachyphylaxis to atp on the response to non-adrenergic, non-cholinergic nerve stimulation has been re-examined.2 quinacrine fluorescence histochemistry revealed a population of nerve fibres, ganglion cells, and nerve bundles in the bladder which were not seen in either the iris or vas deferens, where adrenergic and cholinerg ... | 1978 | 25686 |
| distribution of intrinsic nerve cell bodies and axons which take up aromatic amines and their precursors in the small intestine of the guinea-pig. | | 1978 | 25716 |
| stereoselective interaction of tetrahydroisoquinolines in beta-adrenoceptor systems. | in selected beta1- (heart, lipolysis) and beta2-adrenoceptor (trachea) systems, the interaction of racemic-trimetoquinol (tmq) and the erythro- and threo-diastereomers of 1-(3',4',5'-trimethoxy-alpha-hydroxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (alpha-hydroxy tmq) was investigated. each tetrahydroisoquinoline possessed agonist activity in these beta-adrenoceptor systems. the rank order of potency observed for these compounds was racemic-tmq greater than erythro-alpha-hydroxy tmq g ... | 1978 | 25778 |
| tryptic digestion of immobilized d-amino acid oxidase. | | 1978 | 25787 |
| studies on the involvement of lysosomes in estrogen action, i. isolation and enzymatic properties of pig endometrial lysosomes. | pig endometrium cells, collected by curettage and homogenized in an all-glass potter elvehjem homogenizer, gave a considerably higher yield of intact mitochondria and lysosomes than homogenates of whole uterus obtained with the ultraturrax or the parr bomb. after homogenization of the cells and subfractionation in the presence of mg2, mitochondria and lysosomes equilibrated at the same modal density in isopycnic centrifugation. homogenization and subfractionation in buffers devoid of divalent ca ... | 1978 | 25838 |
| influence of ph, temperature & denaturant on the time course of the autodigestion of porcine pepsin. | | 1977 | 25842 |
| a quantitative cytochemical method for measuring carbonic anhydrase activity. | components of a histochemical method for demonstrating carbonic anhydrase activity have been investigated quantitatively. it was found that it is not necessary to use free-floating sections provided the reaction is done in a reaction medium of controlled depth. this permits the use of normal cryostat sections on glass slides, so making this technique applicable to the cytochemical bioassay of gastrin. the better control of the ph of the reaction, and changes in the concentration of phosphate and ... | 1978 | 25856 |
| sphingomyelinase in pig and human epidermis. | the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase e.c.3.1.4.12) which hydrolyzes sphingomyelin to ceramide (n-acylsphingosine) and phosphorylcholine was identified in the subcellular fractions of pig and human epidermis. the enzyme has an optimum ph of 4.5 to 5 and is activated by triton x-100 (0.1% w/v). approximately two-thirds of the enzyme activity in both the pig and human epidermal homogenates was in the soluble subcellular fraction and more than half of the enz ... | 1978 | 25935 |
| glucose metabolism in hypermyotrophic animals and adipo-muscular relationship. saccharose tolerance test in piétrain and large white pigs (preliminary results). | | 1978 | 25983 |
| metabolic changes in the retina after experimental microembolism in the miniature pig (author's transl). | experimental microembolisation provokes hemodynamics and metabolic changes in the inner retina. the metabolic modifications are the consequence of focal tissue ischaemia and have as a main feature, the activation of anaerobic glycolysis. this activation produces an increase in the production of lactic acid which, in turn, causes a drop of tissular ph. choroidal circulation maintains photoreceptors in a physiological state. | 1978 | 25987 |
| physiolopathology of secondary bronchoconstrictor effects caused by repeated use of adrenergics (experimental study). | | 1978 | 26004 |
| cardiotoxicity of bromethylbutyramide (carbromide) (author's transl). | bromethylbutyramide (carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. the negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poisoning. the cardiodepressive actions of bromethylbutyramide and carbromal may be important for the course and the ending of severe carbromal intoxications. | 1978 | 26320 |
| characteristics of enzymic decarboxylation of l-threo-3,4-dihydroxyphenylserine using hog renal l-aromatic amino acid decarboxylase. | | 1978 | 26357 |
| induced ovulation and synchronized breeding of prepuberal gilts. | | 1978 | 26461 |
| efficient fractionation of collagenolytic sample from oral bacteroides melaninogenicus. | | 1976 | 26476 |
| microsomal mixed-function amine oxidase. oxidation products of piperazine-substituted phenothiazine drugs. | oxidation products of fluphenazide, thioproperazine, and trifluoperazine obtained in reactions catalyzed by homogeneous preparations of the microsomal mixed-function amine oxidase have been isolated and identified. approximately 0.5 g of metabolite of each piperazine-substituted phenothiazine drug was prepared in reactors containing, as catalyst, the purified oxidase covalently attached to glass beads. nuclear magnetic resonance spectra of the isolated products indicated that with all three subs ... | 1978 | 26542 |
| pig brain glutamine synthetase: an interpretation of the sigmoidal kinetics for magnesium and adenosine triphosphate. | | 1978 | 26603 |
| corpus luteum function following subtotal hysterectomy in the prepuberal gilt. | | 1978 | 26652 |
| some pharmacological actions of acetylsecohemicholinium. | the effects of the acetylated derivative of hc-3 (acetylsecohemicholinium; achc-3) have been studied at cholinergic nerve terminals and compared with the effects of the parent compound. achc-3 blocked neuromuscular transmission in nerve-muscle preparations; it was shown to be less effective than hc-3 in producing a pre-junctional block in the rat diaphragm but was more effective than hc-3 in eliciting a post-junctional blocking effect in the chick biventer muscle. on the frog rectus abdominis mu ... | 1978 | 26742 |
| a mammalian muscle with the pharmacological characteristics of slow tonic muscle. | the guinea-pig isolated cremaster muscle gave tetrodotoxin-resistant dose-related contractures with acetylcholine, carbachol and the depolarizing neuromuscular blocking agents. the dose-response curve to suxamethonium in tetrodotoxin 2 x 10(-7)m could be shifted to the right with tubocurarine 10(-6)m. kcl, 0.1m, produced slow sustained contractures of the muscle. with the cremaster nerve-muscle preparation tetanic contractions at 20 hz were maintained over several minutes. tetrodotoxin eliminate ... | 1978 | 26743 |
| the problems associated with the use of 2,2'-pyridylisatogen tosylate in evaluating the allegedly purinergic innervation of peripheral organs. | | 1978 | 26760 |
| the action of enkephalins and enkephaline analogues on neuro-transmission in the isolated nicititating membrane of the cat. | | 1978 | 26780 |
| fundamental research on the pharmacological activity of oriental drugs. xii. pharmacological research on beta-adrenergic potentiation factors included in musk and their organ-selective activity (author's transl). | | 1978 | 26784 |
| synthesis and pharmacological activity and some derivatives of 1-phenyl-1,2,3,4-tetrahydro-5h-1,4-benzodiazepin-5-one. | 4-n-alkylamino derivatives and corresponding ammonium quaternary salts of tetrahydro-1,4-benzodiazepin-5-one were synthesized and evaluated for psychotropic activity in mice by ip via. this study was also extended to some nitro and amino derivatives of tetrahydro-1,4-benzodiazepin-5-one. compounds were devoid of tranquilizing activity and in comparison with two classical benzodiazepines, chlordiazepoxide and diazepam, they showed high toxicity and little or no effect on motor coordination, motor ... | 1978 | 26804 |
| the activation of tyrosine hydroxylase in noradrenergic neurons during acute nerve stimulation. | | 1978 | 26830 |
| biosynthesis of sialic acids. | | 1978 | 26835 |
| humoral factors of natural immunity in animals adapted and deadapted to high-altitude hypoxia. | | 1978 | 27036 |
| existence, localization and some properties of the activators of sphingolipid hydrolases. | | 1978 | 27071 |
| redox modulation of splenic cell soluble guanylate cyclase activity: activation by hydrophilic and hydrophobic oxidants represented by ascorbic and dehydroascorbic acids, fatty acid hydroperoxides, and prostaglandin endoperoxides. | | 1978 | 27074 |