| respiratory response to hypoxia and hypercapnia after elimination of central chemosensitivity. | central respiratory drive responding to ph changes was eliminated by bilateral coagulation or cold block of area s (intermediate area) on the ventral medullary surface in 7 anaesthetized cats. arterial ph, pco2, and po2 (4 cats) and the respiratory response to hypoxia and hypercapnia (6 cats) were observed before and after coagulation. after coagulation in hyperoxia the arterial ph dropped from 7.30 to 7.09, the arterial pco2 was elevated from 4.80 kpa to 8.17 kpa (6 cats). ventilation increased ... | 1979 | 42038 |
| synaptic transmission: ion concentration changes in the synaptic cleft. | currents flowing through the postsynaptic membrane of an active synapse will tend to change the concentrations of ions in the synaptic cleft. published experimental data are used to predict (a) the sodium and potassium concentration changes in the cleft at the frog neuromuscular junction, and (b) the sodium depletion in the cleft under a ia synaptic bouton on a cat motoneuron. significant concentration changes are predicted at both synapses. these changes will contribute to the time dependence o ... | 1979 | 42066 |
| the hyperglycemic response to alpha and beta adrenergic agonists in the cat. | | 1979 | 42084 |
| neurotransmitter systems mediating inhibition of intralaminar thalamic unit activity. | | 1979 | 42085 |
| effect of experimental hydrothorax on the cough reflex in conscious cats. | the authors induced experimental hydrothorax in cats by injecting dextran into the pleural cavity under brief n2o anaesthesia. they examined the parameters of cough -- elicited by mechanical stimulation of the airway mucosa -- and blood gas and ph values under normal conditions and after the injection of 50, 100, 200 and 250 ml dextran. the tests were always performed 30 min after terminating anaesthesia, i.e. in conscious animals. the free fluid in the thorax was found, in conscious cats, to re ... | 1979 | 42093 |
| catecholamine-mediated arrhythmias in acute myocardial infarction. experimental evidence and role of beta-adrenoceptor blockade. | ventricular fibrillation is a major mechanism of sudden death. the cellular link between catecholamine activity and the development of serious ventricular arrhythmias may be in the formation of cyclic adenosine monophosphate (camp). cyclic amp and agents promoting camp accumulation allow development of slow responses which, especially in the presence of regional ischaemia, could develop into ventricular fibrillation. the role of beta-antagonist agents in the therapy of acute myocardial infarctio ... | 1979 | 42151 |
| characteristics of beta-adrenergic-sensitive adenylate cyclase in cerebral vessels. | | 1978 | 42181 |
| effect of galanthamine and galanthamine-eunalgit combination on food motor reflexes in cats. | | 1979 | 42268 |
| adrenergic receptors and others. fourteenth annual becton, dickinson and company oscar schwidetzky memorial lecture. | | 1979 | 42329 |
| [the influence of benzoctamine on dopamine and norepinephrine contents in substantia nigra and on the muscle stretch reflex of the cat (author's transl)]. | the concentration of dopamine (da) and norepinephrine (ne) are decreased to a maximum of 40% and 20%, respectively, in the substantia nigra of precollicular and prenigral decerebrated cats previously treated with benzoctamine (tacitin) (0.7 mg/kg i.v.), while the tyrosine-hydroxylase and mao activities remain unchanged. muscle stretch reflexes recorded simultaneously showed a significant decrease of stretch tension which is evoked by a clear reduction of ia discharges of the primary muscle spind ... | 1979 | 42412 |
| effects of microiontophoretically applied flurazepam on responses of cerebral cortical neurones to putative neurotransmitters. | utilizing standard microiontophoretic techniques and recording extracellularly in cats, we studied the effects of flurazepam, a water-soluble benzodiazepine, on the spike activity of single cerebral neurones and its interactions with several excitatory and inhibitory putative neurotransmitters. large iontophoretic doses (5--30 na, 0.1 m solution) of flurazepam induced a depression of spike amplitude. smaller doses (less than 5 na, 0.1 m solution or 20--50 na, 20 mm in 0.16 m nacl) reduced the ex ... | 1979 | 42477 |
| capillary filtration coefficient: the technique and its application to the small intestine. | in this review, we discuss the physiological basis of the capillary filtration coefficient (kf,c), and its measurement in the small intestine. first the various techniques by which kf,c can be measured are discussed and assessed; the second part of the review considers the volumetric method of determining kf,c in more detail, in an attempt to identify the causes of variability in published values for intestinal kf,c. finally, we discuss changes in intestinal kf,c due to sympathetic nerve stimula ... | 1979 | 42491 |
| the in vivo examination of the irreversible beta-adrenoceptor antagonist ro 03-7894 on cardiac rate and contractility. | 1. two benzofuran-2-ethanolamines ro 03-5255 (1-(5-acetylamino-benzofuran-2-yl)-1-hydroxy-2-isopropylaminoethane) and ro 03-7894 (1-(5-chloracetyl aminobenzofuran-2-yl)-1-hydroxy-2-isopropylaminoethane) which had previously been shown to exhibit respectively competitive and irreversible beta-adrenoceptor antagonism in guinea-pig isolated atria, were compared in vivo using isoprenaline-induced tachycardia of anaesthetized guinea-pigs and heart rate and contractility (dp/dtmax) of open-chest anaes ... | 1979 | 42499 |
| mechanisms of neurohumoral regulation of heart function in aging. | changes in hemodynamics and myocardial contractile capacity following the stimulation of extracardial nerves and administration of various doses of acetylcholine, norepinephrine, propranolol, phentolamin, atropine, serpasil and benzohexonium were studied in albino rats, rabbits and cats of various age. the shifts in cardiac acetylcholine and norepinephrine content and the activity of some enzymes of their catabolism were determined as well. functional changes were compared with the structural sh ... | 1979 | 42543 |
| ganglion blocking properties of some bispyridinium soman antagonists. | various doses of several bispyridinium compounds (hs-6, hi-6, hgg-12, hgg-42, and sad-128) known to protect animals against the irreversible cholinesterase inhibitor soman were examined to determine their effects on the cardiovascular and respiratory system of cats. although the potency varied considerably all of the compounds tested lowered the blood pressure, which appeared to be the result of ganglion blocking properties as determined by their reduction of the pressor response to dimethylphen ... | 1979 | 42547 |
| antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. | two new beta-adrenoceptor blocking drugs with acute antihypertensive and positive inotropic effects are described: compound a (2-[4-(3-tert.butylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole) and mk-761 (2-(3-tert.butylamine-2-hydroxypropoxy)-3-cyanopyridine hydrochloride). in sh rats both compounds, given orally, lowered arterial pressure and were more potent than hydralazine. the antihypertensive effect of compound a but not of mk-761 was antagonized by timolol. both compounds had ... | 1979 | 42553 |
| [effect of vasocative substances on resistance and capacitance vessels under high altitude conditions]. | in cats, i.a. administration of adrenaline (10 microgram), serotonin (30 microgram), and acetylcholine (10 microgram) on the 3rd, 15th, and 30th days of animals stay at 3200 m altitude induced different vasomotor responses in precapillary and postcapillary portions of intestine vascular net during different periods of high altitude adaptation. changes of reactivity in different receptor structures of smooth muscles, the initial tonus of the small intestine resistance vessels associated with the ... | 1979 | 42566 |
| effects of cefoxitin on neuromuscular and autonomic transmission [proceedings]. | | 1979 | 42690 |
| [biochemical seizure mechanism in brain--in reference to neurotransmitters (author's transl)]. | | 1979 | 42857 |
| perivascular ph and pial arterial diameter during bicuculline induced seizures in cats. | the aim of the present study was to correlate locally at the same pial artery the vascular reaction with the perivascular ph during the initial phase of functional hyperemia. as a model of functional hyperemia, bicuculline (3 mg/kg i.v.) induced seizure was taken. normally, a strong increase of blood pressure occurs together with the start of seizure. since a discrimination between metabolically induced and pressure dependent vascular reactions is not possible under such conditions, the cats (an ... | 1979 | 42874 |
| formation area of the statoconia. | | 1979 | 42971 |
| the pharmacology of 20681-s and 20682-s, 6-oxo-n-cyclopropylmethylmorphinans, as narcotic antagonist analgesics. | it has been demonstrated that l-3hydroxy-6-oxo-n-cyclopropylmethylmorphinan methansulfonate (20681-s) and l-3,14-dihydroxy-6-oxo-n-cyclopropylmethylmorphinan methansulfonate (20682-s), have antinociceptive and narcotic antagonistic properties. in the rodent antinociceptive test, the action of 20681-s was more potent and of longer duration than that of morphine and of cyclazocine after subcutaneous or oral administration. the antinociceptive effect of 20682-s ranked between that of morphine and t ... | 1979 | 43119 |
| [on the mechanism of therapeutic actions of psychotropic drugs (author's transl)]. | | 1979 | 43160 |
| antagonism by (+)-amphetamine of the inhibition of [3h]-noradrenaline overflow obtained by alpha-adrenoceptor agonists or bretylium in the perfused cat spleen [proceedings]. | | 1979 | 43177 |
| on the clinical pharmacology of talinolol, a new beta 1-adrenoceptor blocking agent. | | 1979 | 43294 |
| direct and reflex effects of nitroglycerin on the blood volume distribution, evaluated by regional weighing in the cat. | the effects of nitroglycerin on the blood volume distribution were studied with a method of regional weighing in the anaesthetized cat. an i.v. bolus injection of nitroglycerin produced a dose-dependent decrease in arterial pressure accompanying a decrease in the thoracic blood volume. the latter change was associated with blood volume increases principally in the abdomen, and slightly in the hindquarters. elimination of the cardiovascular reflex effects by carotid sinus denervation and cervical ... | 1979 | 43363 |
| release of [3h]noradrenaline induced by 5-hydroxytryptamine from cat pial arteries. | pial arteries of cats were used to analyse the effects of 5-hydroxytryptamine (5-ht) on the release of [3h]noradrenaline. to achieve this the vessels were preincubated with [3h]noradrenaline and the effect of different concentrations of 5-ht (10(-6), 10(-5), 10(-4) m) on the release of tritium was studied. 5-ht elicited release of radioactivity in a dose-dependent manner. removal of both superior cervical sympathetic ganglia 15 days before the experiment of pretreatment of the animals with reser ... | 1979 | 43365 |
| the neuromuscular and autonomic blocking activities of pancuronium, org nc 45, and other pancuronium analogues, in the cat. | twenty-six mono- or bis-quaternary salts of 3,17-dioxy-2 beta, 16 beta-dipiperidino-5 alpha-androstanes (including pancuronium) and one 17-desoxy congener were tested for neuromuscular blocking and autonomic blocking activities in the chloralose-anaesthetized cat. the 17 beta-acetoxy series, all the members of which contain an acetylcholine-like fragment in the steroidal d-ring, was most selective for effecting neuromuscular blockade. the salient member of this series is 3 alpha, 17 beta-diaceto ... | 1979 | 43368 |
| changes in carbon dioxide and ph in pulmonary post-capillary blood in cats [proceedings]. | | 1979 | 43389 |
| effect of inhibitors on the relationship betweeen histamine- and insulin-stimulated gastric hydrogen ion concentration and flow in the cat [proceedings]. | | 1979 | 43392 |
| the influence of preganglionic nerves on the superior cervical ganglion of the rat. | sympathetic neurones grown in tissue culture with non-neuronal cells become cholinergic. such a change from an adrenergic to cholinergic character does not occur in vivo and it has been suggested that this may be due to the determination of the adrenergic character by electrical activity. electrical activity in the superior cervical ganglion by young rats were prevented by transection of the preganglionic nerve trunk. in no case did this operation result in an increase in the intrinsic choline a ... | 1979 | 43489 |
| cat liver cystathionase. | cat liver cystathionase was about 300-fold purified in comparison with the supernatant of the homogenate, and the characteristics were compared with those of rat. optimum phs for several substrates were found to be somewhat lower, and isoelectric point remarkably lower, in cat than in rat. molecular weight of the cat liver cystathionase was about 158,000. | 1979 | 43545 |
| [pharmacological properties of procaterol, a newly synthetized, specific beta 2-adrenoceptor stimulant. part i. effects on the cns (author's transl)]. | effects of procaterol (pro) on the cns were investigated in comparison with those of salbutamol (sal) and isoproterenol (iso). pro, 15 to 50 mg/kg given subcutaneously suppressed spontaneous movement in mice, rats and rabbits and with a large dose, 1000 mg/kg, the animals became quiet and immobile. in dogs, pro produced similar symptoms and in addition, there was nausea and vomiting. the animals recovered within 3--8 hours. id50's in depressing spontaneous movement were 20.2 and 245 mg/kg for pr ... | 1979 | 43821 |
| [pharmacological properties of procaterol, a newly synthesized, specific beta 2-adrenoceptor stimulant. part ii. effects on the peripheral organs (author's transl)]. | pharmacological properties of procaterol (pro) in the peripheral organs were examined in comparison with those of sulbutamol (sal) and isoproterenol (iso). pro slightly enhanced twitch tension of the tibialis anterior muscle but affected little the mono- and poly-synaptic spinal reflexes and ganglionic transmission. pro depressed spontaneous contractions of the isolated ileum, non-pregnant and pregnant uterus and also the gastrointestinal and uterine movements in vivo. pro prolonged the time of ... | 1979 | 43822 |
| enzyme histochemical characteristics of human and kitten odontoclasts and kitten osteoclasts: a comparative study using whole cells. | methods for the histochemical demonstration of enzymes in whole cell preparations of odontoclasts and osteoclasts are described. enzyme histochemical characteristics of human and kitten odontoclasts from resorbing primary teeth and of osteoclasts from kitten femur metaphyses were determined and compared. the enzyme profiles, times for the appearance of detectable reaction product, intensity of the reactions and localization of the reaction products were similar in all three types of giant cell. ... | 1979 | 43859 |
| brain protease activity after experimental head injury. | in an experimental series on twelve cats, activity changes of brain cell proteolytic activity were measured two hours after a blunt head injury without hematoma or contusions. protease activity was estimated in two different brain tissue homogenate supernatants containing total soluble and only cytoplasmic activity without proteases in cell organelles, respectively. total activity was doubled two hours after injury in the acid and the neural ph-range, in comparison to control values. free solubl ... | 1979 | 43883 |
| unimportance of perivascular h+ and k+ activities for the adjustment of pial arterial diameter during changes of arterial blood pressure in cats. | the role of perivascular h+ and k+ in the adjustment of pial arterial diameter during changes in arterial blood pressure was investigated in chloralose anesthetized cats. blood pressure was reduced by i.v. mecamylamine or pentolinium and was increased by i.v. hypertensin. pial arterioles and arteries with a control diameter ranging from 37--218 microns at a spontaneous mean arterial blood pressure of 128 +/- 16 (sd) mm hg were studied. vascular diameter as measured by tv image splitting showed t ... | 1979 | 43961 |
| the effects of sleep on neurons in isolated cerebral cortex. | slabs of cat parietal cortex with some 2 mm of underlying white matter were surgically isolated from the rest of the nervous system, without interference with the superficial blood supply. wire micro-recording electrodes were inserted into the isolated cortex; bone, muscle and skin wounds were repaired and the animal allowed to recover from anaesthesia. the adequacy of surgical isolation was examined histologically 8--12 weeks after operation. only one of the six preparations reported here showe ... | 1979 | 43974 |
| phosphate buffer stimulates somatostatin release into the antral lumen of anaesthetized cats. | the effect of variations of intra-antral ph on the intraluminal release of somatostatin was studied. acute pouches were created in anaesthetized cats, and the pouches were perfused with solutions differing in ph. somatostatin levels were then measured in the perfusates. in this model phosphate buffer was a potent stimulator of intra-antral somatostatin release, whereas perfusion with 0.1 m hcl failed to release somatostatin by itself. since phosphate buffer also releases gastrin, the releasing e ... | 1979 | 44003 |
| effects of aspirin and ph on permeability of isolated perfused pancreatic duct. | | 1979 | 44029 |
| on the antiarrhythmic activity of one n-substituted piperazine derivative of trans-2-amino-3-hydroxy-1, 2, 3, 4-tetrahydroanaphthalene. | the antiarrhythmic activity of the compound n-(trans-3-hydroxy-1,2,3,4-tetrahydro-2-naphthyl)-n-(3-oxo-3-phenyl-2-methylpropyl)-piperazine hydrochloride, referred to as p11, is studied on anaesthesized cats and wistar albino rats, as well as on non-anaesthesized rabbits. four types of experimental arrhythmia are used--with bacl2, with chloroform-adrenaline, with strophantine g and with aconitine. the compound p11 is introduced in doses of 0.25 and 0.50 mg/kg intravenously and 10 mg/kg orally. th ... | 1979 | 44072 |
| [functional and morphological characteristics of the adrenals and kidney juxtaglomerular apparatus under the combined effects of narcotic substances and severe hypoxia]. | | 1979 | 44128 |
| [a review of pharmacological studies on nicergoline]. | 10-methoxy-1,6-dimethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, sermion) shows a strong alpha-blocking activity both in vitro and in vivo. various studies (dog, cat, rabbit, rat, mouse, guinea-pig) show that nicergoline affects only slightly blood pressure and heart rate and increases the blood flow in brain and hind limb without affecting the splanchnic and aortic flow in normal animals. nicergoline does not interfere with cns functions unless applied in high doses. it stimul ... | 1979 | 44197 |
| sk&f 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade. | 1. the properties of a new antihypertensive agent, sk&f 92657, dl-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied. 2. the compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. the beta-adrenoreceptor-blocking actions of sk&f 92657 prevent reflex cadiac stimulation. | 1979 | 44235 |
| neuromuscular transmission. | | 1979 | 44295 |
| determinants of the longevity of third-stage infective larvae of ancylostoma tubaeforme. | the effects of some extrinsic factors on the lipid (energy) reserves and longevity of third-stage larvae of the cat hookworm ancylostoma tubaeforme, were investigated under controlled laboratory conditions. in nonstressful microenvironmental conditions, larval longevity was directly related to the rate of utilisation of the lipid reserves. the effects of the various environmental stresses on longevity could also be explained largely on the basis of their deleterious effects on the lipid metaboli ... | 1979 | 44307 |
| the effect of propranolol on the serotonin concentration in the portal plasma after vagal nerve stimulation in the cat. | efferent cervical vagal nerve stimulation in the cat caused a marked increase of the portal plasma 5-ht concentration. this increase was more than two-fold within 15 min of stimulation. after cessation of stimulation portal plasma 5-ht returned to basal levels within 10 min. treatment with the beta-adrenoceptor antagonist propranolol, in various doses (0.1-2 mg/kg b.wt.), did not abolish but significantly reduced the response to vagal stimulation, particularly during the final part of the stimul ... | 1979 | 44426 |
| on the nature of basal vascular tone in cat skeletal muscle and its dependence on transmural pressure stimuli. | the aim of the present study was to elucidate in some detail the characteristics of the intrinsic basal vascular tone in the adrenergically blocked skeletal muscle with regard to its extent and site along the vascular bed, its dependence on arterial pressure via static and dynamic transmural pressure stimuli, and its sensitivity to local metabolic influence. basal tone, which apparently is of myogenic nature, was pronounced in 'proximal arterial vessels' (greater than 25 mmicrometer i.d.) and in ... | 1979 | 44427 |
| [ether derivatives of 3-amino-1,2-propanediol, ii: synthesis and pharmacological investigation of n-substituted derivatives of 1-cycloalkyloxy-3-amino-2-propanols (author's transl)]. | | 1979 | 44460 |
| [synthesis and pharmacological investigation of ether derivatives of 3-amino-1,2,-propanediol, i]. | | 1979 | 44461 |
| [comparative study on the depressive action of several benzodiazepine minor tranquilizers (author's transl)]. | the potencies of four benzodiazepine minor tranquilizers in depressing respiratory function were investigated in rats and cats anesthetized with pentobarbital. the effect of the drug on respiration was studied in the rat, and the effect on the phrenic nerve activity which reflects the activity of an inspiratory centre was investigated in the cat vagotomized bilaterally at the level of the neck. the change of blood pressure, heart rate and pco2 in expiration were also recorded simultaneously in e ... | 1979 | 44510 |
| histamine h1- and h2- receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle. | intra-arterial fusions of histamine cause vasodilation of resistance vessels, extravasation of albumin and oedema in cat skeletal muscle. treatment with either mepyramine or metiamide significantly reduced the extravasation of albumin and rate of oedema formation. the doses of mepyramine and metiamide used did not modify the vascular responses to bradykinin. | 1979 | 44659 |
| [reciprocal responses to macular stimulation of neurons localized in the region of the forelimb and of the hindlimb of deiters nucleus]. | in decerebrate cats with cerebellum intact the frequency response of 102 neurons located within the lateral vestibular nucleus (nvl) to sinusoidal stimulation of vestibular receptors was analyzed. positional sensitive units, showing a reciprocal pattern of response to lateral tilting characterized by an excitation during ipsilateral and a depression during contralateral tilt, were equally found in the rostroventral (forelimb) and dorsocaudal (hindlimb) divisions of the nvl. no unit was found to ... | 1979 | 44844 |
| comparative attachment of neisseria gonorrhoeae and of gonococcal pili to various mammalian sperm. | | 1979 | 44855 |
| [transmission of toxoplasma oocysts from domestic cats to rabbits (author's transl)]. | the importance of the role of toxoplasma oocysts in the mode of spread of the infection for men and animal has differently been estimated. in own earlier experiments, we found out that the transmission of the infection by means of oocysts from cat to cat is not the rule. in a similar experimental setup, we tested now whether rabbits can be infected by getting into contact with faeces of cats containing sporulated toxoplasma oocysts (see table 1). 8 toxoplasma-free rabbits and two toxoplasma-free ... | 1979 | 44948 |
| polyarteritis in a cat. | | 1979 | 45213 |
| bicarbonate atp-ase in ciliary body and a theory of diamox effect on aqueous humor formation. | bicarbonate was found to stimulate atp breakdown by rabbit or cat ciliary body-iris homogenates. maximum hco3- stimulation of atpase with tris-hepes buffer occured at ph 8.0. acid ph and chloride ions in the media reduced the activity of the hco3--stimulated atpase. the km for atp was 0.55 mmolar and for hco3-, 20 mmlar. hco3- atpase was not inhibited by acetazolamide added to in vitro. it is postulated that atpase represents the linkage step of energy donor mechanism and active ct secretion in ... | 1979 | 45223 |
| [ventilatory effects of various respiratory stimulants in awake cats (author's transl)]. | | 1979 | 45310 |
| antagonistic properties of n-methyl-n'-[2-(5-ethyl-4-imidazolyl-methylthio)ethyl]thiourea. | in the present paper the authors describe the synthesis and the biological effects of n-methyl-n'-[2-(5-ethyl-4-imidazolylmethylthio)ethyl]thiourea (etiamide). this compound appeared to inhibit, to a certain extent, the effect of histamine on h2-receptors. this inhibition, however, was less pronounced than that elicited by metiamide and in some of the preparations examined appeared to be of the non-competitive type. | 1979 | 45316 |
| [the morphologic diversity and complexity of synapses and microcircuits]. | after mentioning the dendrite arborizations and the dendritic spines which represent an important site of synaptic interactions and neuronal plasticity, the main synaptic types, chemical and electrical, excitatory and inhibitory are mentioned and their morphological characteristics and dynamic properties are discussed. in the second part, the synaptic connections between several nerve cells, and the module principle of cerebellar and cerebral cortex are described. significant progress is expecte ... | 1979 | 45341 |
| involvement of gaba in the actions of neuropsychotropic drugs. | | 1979 | 45449 |
| functional mechanism of the striatum by integration of nine types of synapses which have at least seven different transmitters. | | 1979 | 45452 |
| failure of total calcium corrected for protein, albumin, and ph to correctly assess free calcium status. | the clinical effectiveness of published algorithms in correcting serum total calcium (cat) for the effects of protein, albumin, and ph was tested. corrected calcium (cac) values obtained by 13 of these methods were compared with values of measured free calcium (caf) in 55 samples from normal controls and 404 samples from patients with various disorders of calcium metabolism. three criteria were used to compare either cac or cat with measured caf: 1) the correlation coefficient, 2) the average ab ... | 1978 | 45478 |
| possible changes in striatal and limbic cholinergic systems in schizophrenia. | enzymes concerned with neurotransmitter metabolism were measured postmortem in 50 regions from the brains of 11 chronic schizophrenics, 2 patients with senile dementia, 1 depressive, and 18 controls. enzymes studied were tyrosine hydroxylase, dopa decarboxylase, glutamic decarboxylase, choline acetyltransferase (cat), and acetylcholinesterase. the schizophrenic group had high cat activities in the hippocampus, caudate, putamen, and nucleus accumbens; the other patients from the same hospital did ... | 1977 | 45482 |
| ahr-6646: a new, long-acting neuroleptic. | 1. ahr-6646 blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. 2. conditioned avoidance responding in mice and cats was suppressed by ahr-6646 in doses that did not impair escape behavior. the duration of this effect was markedly prolonged. 3. ahr-6646 produced catalepsy in rats. the onset of this effect was delayed and the duration was prolonged when compared with that of chlorpromazine. 4. apomorphine-induced ... | 1979 | 45570 |
| neurons of the dorsal lateral geniculate nucleus of the albino rat. | light and electron microscopic observations were made on the dorsal lateral geniculate nucleus (dlgn) of 33 young adult male albino rats. three variants of the golgi silver impregnation technique were employed in the light microscopic studies. neurons were classified into three categories based on location, dendritic pattern, and dendritic appendages. type 1 and type 3 neurons were distributed throughout the dlgn. type 2 neurons were located in the superficial zone. dendritic appendages of type ... | 1975 | 45862 |
| thalamic afferents to areas 17, 18 and 19 of cat cortex traced with horseradish peroxidase. | | 1975 | 46157 |
| differential projections of the nucleus raphe dorsalis and nucleus raphe centralis as revealed by autoradiography. | | 1975 | 46163 |
| the retinal projection to the ventral lateral geniculate nucleus of the cat. | | 1975 | 46169 |
| the effect of postmortem trauma on neuronal cell types strained histochemically for phospholipids. | | 1975 | 46202 |
| reconstruction of axonal trajectory of individual neurons in the spinal cord using golgi-stained serial sections. | a procedure bringing the axonal and dendritic cut ends found in the confronting planes of the serial sections face to face by means of serial photomicrographs provides a means for precisely reconstructing individual golgiimpregnated neurons. utilizing this method, it was possible to follow at the caudal level of a kitten's spinal cord the total course of the axons and dendrites of sixteen intramedullary neurons. the neurons located in the dorsal horn (laminae iv and v) send their long ascending ... | 1975 | 46232 |
| the distribution of the alpha type of ganglion cells in the cat's retina. | there is a distinct class of large ganglion cell bodies observable in whole-mount preparations of the cat's retina stained with cresyl violet. measurements of perikaryal size and its variation with eccentricity from the central area support the identification of the large cells with the class of alpha cells previously defined in golgi-stained preparations. a complete enumeration of alpha cells in one retina yielded a total of 6212. they were encountered in all parts of the retina and had a peak ... | 1975 | 46233 |
| regression of feline sarcoma virus-induced sarcomas in dogs. ii. immunologic investigations. | the serial development of cell-mediated immunity (cmi), cytotoxic antibody activity, serum blocking activity, and virus-neutralizing antibody levels were monitored in vitro for beagle and mongrel puppies inoculated with feline sarcoma virus (fesv) and were compared to in vivo histologic markers of regression of induced sarcomas. cmi developed rapidly and maintained a high level of in vitro activity throughout the tumor life-span. cytotoxic antibody levels similarly rose rapidly to peak just befo ... | 1975 | 46276 |
| editorial: too big to be visible. | | 1975 | 46343 |
| letter: graft-versus-host atherosclerosis. | | 1975 | 46542 |
| batrachotoxin block of fast axoplasmic transport in mammalian nerve fibers. | batrachotoxin (btx) irreversibly blocks fast axoplasmic transport in nerve in concentrations as low as 0.2 micromolar. the action of btx was studied in cat sciatic nerves in vitro by measuring the rate of the crest outflow after injection of the l7 dorsal root ganglion with [3-h]leucine. tetrodotoxin, which in itself does not affect fast axoplasmic transport, inhibited the blocking action of btx. unlike the btx block of nerve and muscle membrane excitability brought about through increased perme ... | 1975 | 46619 |
| alcian blue-tartrazine; a simple differential stain for the fundic gland cells of mammalian stomach. | | 1975 | 46639 |
| cerebral malformation in a manx cat. | | 1975 | 46648 |
| an adrenergic component of the nervous apparatus of the aortic reflexogenic zone. | the structural organization of the adrenergic (sympathetic) component of the autonomic innervation of the depressor zone of the cat aortic arch was studied by luminescence microscopy of the catecholamines. a terminal adrenergic plexus, branching extensively in the connective-tissue basis of the depressor area of the aortic arch, was discovered. the participation of vessels supplying blood to the depressor area was established. adrenergic neurons were found in the territory of the depressor zone ... | 1975 | 46763 |
| effect of hippocampectomy on sleep patterns in cats. | the study was planned to see if the hippocampus has an influence on fast wave sleep (fws) as well as on slow wave sleep (sws). from 8 male cats eeg, emg and eog were recorded for 24 h, first under normal conditions, secondly after cortical damage to the dorsal marginal portion of posterior ectosylvian gyrus, and thirdly following hippocampectomy done through the cortical damage. from the records, sws, fws and the sleep state (defined as a sequence of sws or sws-fws phases between two successive ... | 1975 | 46801 |
| eye movement related activity in the visual cortex of dark-reared kittens. | kittens reared in total darkness from birth were found to be behaviorally blind, when tested at the age of 15-20 weeks. visual cortex eegs were recorded with transcortical electrodes. during waking, potentials related to saccadic eye movements (emp's) were present in the dark, though they were depressed in amplitude in the light. during paradoxical sleep, rapid eye movements, isolated or in bursts, were present at a normal rate, as were occipital waves related to ponto-geniculo-occipital activit ... | 1975 | 46807 |
| single unit activity in the lateral amygdala of the cat during sleep and waking. | neuronal activity of 58 cells in the lateral nucleus of the amygdala of freely moving cats was studied across stages of sleep-wakefulness. in general, these units were very slow firing in all states (mean discharge rate less than 1 spike/sec) with the highest rates typically observed during slow wave sleep and paradoxical sleep. most units tended to show some bursting activity during all states. the bursting during paradoxical sleep was not temporally correlated with the phasic activity characte ... | 1975 | 46813 |
| an application of long-term frequency analysis in measuring drug-specific alterations in the eeg of the cat. | a method is described for the quantitative measurement of "drug-specific" effects on the eeg of the cat. these effects are dose-related and are independent of the normal sources of eeg variation associated with the sleep-waking cycle. drug-induced changes are expressed as characteristic alterations in frequency spectra and the time courses of these effects are followed for 5 h following administration of the test compounds. atropine sulfate (0.5 and 2.0 mg/kg) and physostigmine salicylate (0.05 ... | 1975 | 46814 |
| spinal cord potentials evoked by peripheral nerve stimulation. | lumbar, thoracic, and cervical spinal cord responses evoked by sciatic nerve stimulation were measured in 20 cats at the skin level and directly from the dorsal surface of the cord. computer averaging techniques were used for both skin level recordings and cord surface recordings at all levels. recordings made directly from the cord surface at lumbar levels were large and were characterized by a large, initial, negative transient, followed by a more complicated and variable waveform. as recordin ... | 1975 | 46815 |
| use of the analytical electron microscope (aem) in cytochemical studies of the central nervous system. | central nervous tissues (median eminence and arcuate nucleus) were studied by means of energy dispersive x-ray analysis using electron optical systems (analytical electron microscopy). these studies were conducted after the tissue had been treated specifically for localized biogenic amines (ba). the results indicate that not only is the ba cytochemical reaction highly specific, and that bas can be localized intraneuronally in areas not previously identified, but also that the analytical electron ... | 1975 | 46860 |
| editorial: as in cats, so in man? | | 1975 | 46966 |
| direct inhibition of gastric acid and pepsin secretion by growth-hormone release-inhibiting hormone in cats. | growth-hormone release-inhibiting hormone (g.h.-r.i.h.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. this effect is mediated by a direct action on the parietal and peptic cells. no evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. in view of its widespread actions and its presence in relatively high concentrations in various o ... | 1975 | 47536 |
| form and function of cat retinal ganglion cells. | recent explorations of the morphology of retinal neurones, combined with neurophysiological recordings have made it possible to link specific anatomical types with particular physiological classes. at the same time, the relatively complete anatomical mapping of the retina has revealed some bias in the sampling of neurones by electrophysiological techniques. | 1975 | 47614 |
| the oncogene hypothesis and the search for human cancer virusus. | | 1975 | 47649 |
| rna processing and rna tumor virus origin and evolution. | the results of molecular hybridization experiments with high-molecular-weight rna isolated from rna tumor viruses and dna from normal cells suggest that rna tumor virus genomes originate from cell genes. some rna tumor viruses (here called class 1) appear to have been generated in recent times in that their rna is closely related in nucleotide sequence to certain cell genes (class 1 genes). a second class of rna tumor viruses (here called class 2) is more distantly related to genomic information ... | 1975 | 47650 |
| [role of specific impulses in the postnatal formation of chemical activity in microstructures of the animal brain visual analyzer]. | | 1975 | 47670 |
| acute adverse effects of antibiotics. | a review of selected clinical reports in man and experimental studies in lower animals suggests that, under certain circumstances, several commonly used antibiotics may cause cardiovascular depression, respiratory difficulties, or alter the metabolic breakdown of other drugs. these untoward responses are believed to be due to the direct effects of antibiotics on specific physiologic functions, rather than to be related to allergic reactions or cytotoxic lesions. severe pathologic conditions, ove ... | 1975 | 47856 |
| olivocochlear and vestibular efferent neurons of the feline brain stem: their location, morphology and number determined by retrograde axonal transport and acetylcholinesterase histochemistry. | anterograde degeneration studies have shown that the cochlear and vestibular receptor organs receive an efferent innervation from neurons in the brain stem. this pathway may provide a mechanism by which the cns could modulate its own afferent input. the neurons which provide this innervation have so far escaped positive identification with methods which depend on retrograde cell changes after axotomy. in the present study, horseradish peroxidase (hrp) was injected into the labryinths of kittens ... | 1975 | 47866 |
| spasmolytic constituents of cedrus deodara (roxb.) loud: pharmacological evaluation of himachalol. | himachalol has been identified as the major antispasmodic constituent in the wood of cedrus deodara. the pharmacological studies of himachalol on various isolated smooth muscles (guinea pig ileum, rabbit jejunum, rat uterus, and guinea pig seminal vesicle) and against different agonists (acetylcholine, histamine, serotonin, nicotine, and barium chloride) indicated spasmolytic activity similar to that of papaverine. it was a more potent antagonist of barium chloride-induced spasm of guinea pig il ... | 1975 | 47907 |
| axonal transport and the use of intracellular markers in neuroanatomical investigations. | | 1975 | 48479 |
| retrograde axonal transport of horseradish peroxidase in peripheral autonomic nerves. | an exogeneous marker protein, horseradish peroxidase (hrp) was used to race peripheral autonomic pathways in adult guinea pigs and cats. small doses of hrp were injected into various organs and after a brief survival period, hrp activity appeared in the perikarya of autonomic neurons that supplied each injection site. after injection of hrp into the anterior chamber of the eye, reaction product was detected in the postganglionic sympathetic neurons of the superior cervical sympathetic ganglion. ... | 1975 | 48519 |
| letter: epidemiology of leukaemia. | | 1975 | 48744 |
| isolation from the asian mouse mus caroli of an endogenous type c virus related to infectious primate type c viruses. | treatment of a cell line derived from the asian feral mouse mus caroli with 5-bromodeoxyuridine induces an infectious, xentropic type c virus. this virus shares strongly cross-reactive reverse transcriptase (rna-dependent dna polymerase) and p30 antigens and crossinterferes with type c viruses isolated from a woolly monkey (ssav) and gibbon apes (galv). by similar criteria, the caroli virus is much less related to previously described type c viruses of the laboratory mouse, mus musculus. inducti ... | 1975 | 49058 |
| isolation of a type c virus (fs-1) from the european wildcat (felis sylvestris). | | 1975 | 49122 |
| demonstration of nigrothalamic connections in the cat by retrograde axonal transport of horseradish peroxidase. | | 1975 | 49210 |