| airway mucus. | airway surface liquid (asl), a mixture of periciliary fluid and submucosal gland secretions, was collected from the ferret isolated trachea in vitro. the trachea was closed, without possibility of evaporation. the collected asl was hyperosmolar (310-350 mosmol.kg-1) compared with krebs-henseleit solution (280 mosmol.kg-1). compared with surrounding krebs-henseleit solution, the asl had higher sodium and chloride contents, and considerably higher potassium and calcium contents. the asl was acid ( ... | 1989 | 2703039 |
| visual cortex development in the ferret. i. genesis and migration of visual cortical neurons. | the production of ferret visual cortical neurons was studied using 3h-thymidine autoradiography. the genesis of cortical neurons begins on or slightly before embryonic day 20 (e20) of the 41 d gestational period, continues postnatally until 2 weeks after birth (p14), and follows an inside-out radial gradient with neurons for the deeper cortical layers being generated before those for the superficial layers. layer i neurons are generated both early (e20-e30) and late (p1-p14) in the period of cor ... | 1989 | 2703875 |
| dietary beta-carotene absorption and metabolism in ferrets and rats. | the ability of the ferret (mustela putorius furo) to absorb dietary beta-carotene was studied to determine its appropriateness as a laboratory animal model for studies on beta-carotene metabolism. at baseline, the mean serum beta-carotene level in ferrets was 0.6 micrograms/dl and no beta-carotene was present in liver or adipose tissue. after the ferrets were fed 4 or 20 mg of beta-carotene/kg body wt daily for 2 wk, serum levels were 15.3 and 41.5 micrograms/dl, liver values were 0.9 and 4.1 mi ... | 1989 | 2703921 |
| binding of the 5-ht3 ligand, [3h]gr65630, to rat area postrema, vagus nerve and the brains of several species. | the radiolabelled derivative of the potent and selective 5-ht3 receptor antagonist, gr65630, has been shown to label 5-ht3 receptors in homogenates of rat entorhinal cortex. we now report on the specific binding of this radioligand in homogenates of 16 discrete brain areas from several species and nine areas of human brain. we have further characterised specific binding to homogenates of rat area postrema and vagus nerve. in all species examined (rat, mouse, rabbit and ferret) the highest level ... | 1989 | 2707305 |
| evidence for the delayed expression of a brainstem abnormality in albino ferrets. | previous reports have suggested that neurons of the medial superior olivary nucleus in albino cats and rabbits are smaller than those in normally pigmented strains. in this investigation, the mean cross-sectional areas of neuronal perikarya in the medial superior olivary nucleus of pigmented and albino ferrets were compared at juvenile (14 weeks) and adult (greater than six months) ages. the mean cross-sectional area of the perikarya in adult albino ferrets was found to be 45% smaller than that ... | 1989 | 2707342 |
| lamellar bodies are markers of cholinergic neurons in ferret nucleus basalis. | lamellar bodies are composed of stacks of closely-packed, ribosome-free cisterns which are in continuity with the rough endoplasmic reticulum. in the ferret nucleus basalis stained for choline acetyltransferase it was shown, by correlating light with electron microscopy, that only the cholinergic cells there possess lamellar bodies. the significance of lamellar bodies in the cholinergic neurons of the nucleus basalis is not known, but these structures may reflect a peculiar aspect of the functio ... | 1989 | 2709049 |
| nitrite-cured meats as a source of endogenously and exogenously formed n-nitrosoproline in the ferret. | nitrite-cured meat containing 120 mg na15no2/kg was fed to male ferrets (mustela putorius furo). during consumption of the meat, the animals were dosed orally with 0.87 mmol [2-2h]proline. all urine was collected throughout the study and analysed for total n-nitrosoproline (npro) and isotopic enrichment of npro by mass spectrometry. the cured-meat diet increased the urinary excretion of npro 14-fold. isotope analyses indicated that approximately 70% of the npro came from the cured meat, the majo ... | 1989 | 2714715 |
| isoflurane and halothane inhibit tetanic contractions in rabbit myocardium in vitro. | rabbit right ventricular papillary muscles were tetanized by rapid stimulation in the presence of 1 microm ryanodine, an inhibitor of sarcoplasmic reticular function. tetanic contractions elicited in this manner increased in strength as extracellular calcium concentration [ca+2]ext was raised from 0.5 to 5 mm, exhibited saturation behavior above [ca+2]ext = 5 mm, and were blocked by nifedipine. accompanying membrane potentials depolarized to +10 mv and repolarized to -60 mv between stimuli. thes ... | 1989 | 2719319 |
| 5-ht3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. | 1. the purpose of the present study was to identify and investigate the role of 5-hydroxytryptamine3 (5-ht3) receptors in the area postrema in the control of cisplatin-induced emesis in the ferret. 2. homogenate binding and autoradiography experiments using the high affinity 5-ht3 receptor ligand, [3h]-gr65630, identified the presence of a high concentration of 5-ht3 receptors in the area postrema of the ferret. 3. intraperitoneal injection of the 5-ht3 receptor antagonists, gr38032f, gr65630a a ... | 1989 | 2720310 |
| effects of arginine-free diet on urea cycle enzymes in young and adult ferrets. | young ferrets develop hyperammonemia soon after eating an arginine-free diet, whereas adult ferrets do not develop hyperammonemia after an identical treatment. earlier reports indicate that young or adult rats do not develop hyperammonemia and encephalopathy after a single meal of an arginine-free diet. the effects of a single feeding of an arginine-free diet on the urea cycle enzyme activities in the liver of young and adult ferrets is reported. ornithine carbamyl transferase, carbamyl phosphat ... | 1989 | 2721482 |
| treatment of proliferative colitis in ferrets. | proliferative colitis associated with intracellular campylobacter sp was diagnosed in 10 ferrets. the ferrets had a history of diarrhea (often blood-tinged or mucoid), dehydration, and chronic weight loss. additional clinical signs included rectal prolapse, lethargy, fever, and a palpably thick colon. in 5 ferrets, the diagnosis was confirmed by colonic biopsy, via endoscopy. supportive treatment in 5 ferrets did not alleviate the clinical signs or the proliferative intestinal disorder. oral chl ... | 1989 | 2722636 |
| zygomatic salivary gland mucocele in a ferret. | a zygomatic salivary gland mucocele was diagnosed in a 1-year-old female domestic ferret with exophthalmos. a t-shaped incision from near the lateral canthus to the base of the ear and continuing ventrally to the level of the commissure of the mouth was made to expose the mucocele. surgical removal was complicated by the large open orbit of the ferret, adjacent cellulitis, extension ventromedial to the globe, and difficulty in identifying important motor nerves. vision was maintained, but slight ... | 1989 | 2722637 |
| diversity of serotypes of campylobacter jejuni and campylobacter coli isolated in laboratory animals. | one hundred nineteen isolates of campylobacter jejuni and campylobacter coli from nine laboratory animal species were serotyped using antisera to 20 penner serotypes commonly isolated from cases of human enteric infections. although c. jejuni and c. coli were isolated from laboratory animals with diarrhea, the majority were cultured from asymptomatic animals (81%). seven of twenty-two isolates from animals with diarrhea were serotype 4 (32%) and three were serotype 1 (14%). sixty-one of the 119 ... | 1989 | 2724920 |
| agonist-specific myosin phosphorylation and intracellular calcium during isometric contractions of arterial smooth muscle. | the relationship between phosphorylation of the 20-kda myosin light chain, intracellular calcium levels ([ca2+]i), and isometric force was studied during prolonged activation of arterial smooth muscle. aequorin, preloaded into ferret aortic strips, was used as a [ca2+]i indicator. two dimensional polyacrylamide gel electrophoresis was used to determine the phosphorylation levels of the 20-kda myosin light chain (lc20). during the 30-min depolarization of arterial smooth muscle by k+ (21 mm), bot ... | 1989 | 2726426 |
| mechanism of immunity to influenza: maternal and passive neonatal protection following immunization of adult ferrets with a live vaccinia-influenza virus haemagglutinin recombinant but not with recombinants containing other influenza virus proteins. | neonatal ferrets are protected against infection with influenza virus by milk-derived anti-influenza virus igg after suckling on an immune mother. live vaccines protect better than killed vaccines despite their stimulation of lower maternal haemagglutination-inhibiting antibody levels. this suggests that antibody to virus proteins other than the haemagglutinin may also be involved. to investigate this, adult ferrets were immunized intradermally with live vaccinia-influenza virus recombinants eac ... | 1989 | 2732721 |
| influenza a (h1n1) vaccine efficacy in animal models is influenced by two amino acid substitutions in the hemagglutinin molecule. | the immunogenicity and protective efficacy of formalin-inactivated vaccines prepared from influenza a (h1n1) viruses grown in mdck cells and in eggs was compared in animal models. the a/chr/157/83 virus grown in mdck cells (157m) differed by two amino acid substitutions in the ha molecule from the corresponding virus grown in eggs (157e) and the two viruses could be distinguished antigenically by monoclonal and polyclonal antibodies. following two intramuscular injections of vaccine in ferrets, ... | 1989 | 2741341 |
| mechanisms of positive inotropic effects and delayed relaxation produced by dpi 201-106 in mammalian working myocardium: effects on intracellular calcium handling. | 1. we used the bioluminescent protein aequorin, which emits light when it combines with ca2+, to test the hypothesis that the inotropic and lusitropic actions of dpi 201-106 are due to changes in intracellular ca2+ handling in papillary muscles from ferrets and guinea-pigs. 2. dpi 201-106 increased peak isometric tension (t) in a dose-dependent manner, with an 83% increase in t as the concentration of dpi 201-106 was increased to 1 x 10(-5) m; however, peak [ca2+]i did not increase significantly ... | 1989 | 2743084 |
| electrolyte and other chemical concentrations in tracheal airway surface liquid and mucus. | with the ferret in vitro tracheal preparation, we measured the electrolyte and chemical composition of airway surface liquid (asl) under control conditions and when drugs were added to promote submucosal gland secretion and to change epithelial ion transport. control asl was hyperosmolar (342 +/- 2.8 mosmol/kg) compared with ferret plasma and surrounding buffer. higher values were also found for sodium (167 +/- 1.7 mmol/l), potassium (9.0 +/- 0.05 mmol/l), total calcium (3.46 +/- 0.11 mmol/l), a ... | 1989 | 2745281 |
| electromechanical coupling of ferret airway smooth muscle in response to leukotriene c4. | we investigated the possible electrophysiological basis for the slow, prolonged force generation by airway smooth muscle (asm) produced by leukotriene c4 (ltc4). preparations of asm were made from ferret trachea and placed in tissue microchambers for study. some of these preparations were arranged so that force transducers and intracellular microelectrodes (with tip resistances of 30-80 m omega) could be used to measure isometric force and cell membrane potential (em) simultaneously from asm cel ... | 1989 | 2745315 |
| cellular fatty acid composition of campylobacter pylori from primates and ferrets compared with those of other campylobacters. | the cellular fatty acid profiles of newly described campylobacters were determined on a polar, capillary column. six isolates of the gastric spiral organism, campylobacter pylori subsp. mustelae, from ferrets from australia, england, and the united states were all found to have a similar fatty acid profile which was different from that of c. pylori from humans; c. pylori subsp. mustelae did not have 3-hydroxyoctadecanoic acid (3-oh c18:0) and had much less tetradecanoic acid (c14:0) and much mor ... | 1989 | 2745703 |
| effects of saponin on contractile force and intracellular ion activities of cardiac tissues. | the effects of the glycoside saponin on ferret ventricular muscle have been investigated. saponin produced a positive inotropic effect, the extent of which was determined by the bathing calcium concentration. if the bathing calcium concentration is reduced to levels equivalent to those found intracellularly then similar saponin concentrations are able to "skin" the cardiac cells. the effects were further investigated in sheep heart purkinje fibres. in the presence of normal extracellular calcium ... | 1989 | 2746654 |
| pressure response to quick volume changes in tetanized isolated ferret hearts. | observed pressure responses to quick volume changes in the isolated tetanized heart of ferrets were compared with previously reported tension responses to quick length changes in isolated cardiac muscle. hearts were isolated from ferrets, perfused with ryanodine solution, and stimulated rapidly (50 ms between stimulations) to produce repeated 4-s intervals of tetanus. during each tetanus interval, volume increments of different amplitudes were rapidly removed and then reinfused into the left ven ... | 1989 | 2750948 |
| a comparative study of three methods for intracellular loading of the calcium indicator aequorin in ferret papillary muscles. | we compared the results of loading the bioluminescent ca++ indicator aequorin by standard microinjection techniques to those obtained with two new chemical approaches to loading that utilize low concentrations of ca++ chelator; i.e., 1) immersion and 2) macroinjection. after loading with the immersion and macroinjection methods, twitch tension returned to pre-load values indicating lack of damage to the muscles. the aequorin signals obtained with all three methods were similar and converted to s ... | 1989 | 2751658 |
| brainstem auditory evoked response in the ferret (mustela putorius). | the effect of click intensity, repetition rate and binaural interaction on the brainstem auditory evoked response (baer) was examined in sixteen pigmented adult male ferrets. potentials were recorded from platinum needle electrodes inserted over the vertex and left and right mastoids. square waves, 100 microseconds in duration, were transduced by earphones enclosed in an assembly designed to fit securely over the ferret's external ear. the baer in the ferret consists of four prominent vertex-pos ... | 1989 | 2753828 |
| laboratory characterization of a swine influenza virus isolated from a fatal case of human influenza. | a swine influenza virus-like type a (h1n1) virus, designated a/wisconsin/3523/88, was isolated in september 1988 from a wisconsin woman who had died with primary viral pneumonia. antigenic analyses with hemagglutinin-specific monoclonal antibodies and postinfection ferret serum indicated that the hemagglutinin of a/wisconsin/3523/88 was antigenically closely related to viruses currently circulating in swine. genetic analysis of the a/wisconsin/3523/88 virus by rna fingerprinting and partial rna ... | 1989 | 2754013 |
| use of membrane filters and osmium tetroxide etching in the preparation of sperm for scanning electron microscopy. | a new method was developed which is suitable for the preparation of mammalian sperm for scanning electron microscopy under either laboratory or field conditions. samples of ejaculates from humans, two ferret species, and epididymal sperm from the african elephant were diluted in millonig phosphate buffer and then fixed in glutaraldehyde solution. a small sample of the fixed sperm suspension was diluted in the same buffer, withdrawn with a syringe, and injected very slowly onto either a cellulose ... | 1989 | 2754503 |
| evidence that oestrogen exerts an equivalent negative feedback action on lh secretion in male and female ferrets. | gonadally intact male ferrets in breeding condition, which received an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (atd) s.c. in silastic capsules, had significantly more lh pulses and higher mean lh concentrations in plasma than did control males implanted with empty capsules. aromatase activity in the hypothalamus + preoptic area and temporal lobe was strongly suppressed by atd treatment whereas circulating concentrations of testosterone and oestradiol were not affected. these results ... | 1989 | 2754643 |
| the constitution and properties of phosphorylated and unphosphorylated c-terminal fragments of progastrin from dog and ferret antrum. | antibodies to the extreme c-terminal tryptic (nona-) peptide fragment of porcine progastrin have been used in radioimmunoassay to identify progastrin fragments in dog, ferret and pig antral mucosa extracts and to monitor their purification. in addition to previously characterised phosphorylated and unphosphorylated c-terminal tryptic peptides of porcine progastrin a minor form corresponding to the c-terminal octapeptide (i.e. des-ser c-terminal nonapeptide) was isolated and characterised. the la ... | 1989 | 2756156 |
| the ferret as an animal model in cerebrovascular research. | clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (mustela putorius furo) and those of more traditional animal models employed in stroke research. experimental work has demonstrated advantages of the ferret as a model of visual development. we performed in vivo cerebral angiography and postmortem neurovascular dissection of latex-injected specimens of adult ferrets. the great vessels include a cervical arterial trunk that gives rise to ... | 1989 | 2756540 |
| lymphatic filariasis. brugia malayi infection in the ferret (mustela putorius furo). | | 1989 | 2757121 |
| involvement of the protein kinase c system in calcium-force relationships in ferret aorta. | 1. intracellular ca2+-force relationships were investigated in ferret aortic smooth muscle by the simultaneous measurement of aequorin luminescence and isometric force. complete calcium-force curves were constructed by plotting calibrated aequorin luminescence versus force, while intracellular [ca2+] was made to change by increasing degrees of k+ depolarization or decreasing extracellular [ca2+]. 2. the steady state calcium-force curve in response to k+ depolarization exhibited maximal force gen ... | 1989 | 2758222 |
| antiarrhythmic peptide has no direct cardiac actions. | the electrophysiologic, inotropic, and muscarinic effects of antiarrhythmic peptide (aap) were examined in canine cardiac purkinje fibers, ferret papillary muscle, and canine cardiac membranes, respectively. aside from a prolongation of time to peak force in papillary muscle, no biologically significant effects of aap could be determined in any preparation, suggesting that its antiarrhythmic effects are not mediated by direct membrane actions. | 1989 | 2759204 |
| assessment of signs of influenza illness in the ferret model. | the ferret model of influenza a infection was evaluated to determine whether physical signs of influenza illness in addition to fever could be adequately followed. ferrets were evaluated for nasal and systemic signs of influenza infection in a blinded, randomized protocol. nasal signs were scored depending on the degree of nasal discharge and congestion. systemic signs were evaluated on the basis of the activity level of ferrets. nasal and systemic signs in ferrets challenged with influenza bega ... | 1989 | 2760163 |
| efficacy of inactivated influenza a virus (h3n2) vaccines grown in mammalian cells or embryonated eggs. | influenza virus (h3n2) host cell variants isolated from a single infected individual were compared for their protective efficacies when used as formalin-inactivated purified whole virus vaccines in ferrets. a/mem/12/85 virus grown in embryonated chicken eggs (egg-grown), which differs from a/mem/12/85 grown in mammalian madin-darby canine kidney cells (mdck-grown) by a single amino acid substitution in the hemagglutinin molecule, was shown to be distinguishable by immune ferret serum. ferrets we ... | 1989 | 2760480 |
| interstitial cell adenoma in a ferret. | | 1989 | 2761242 |
| subclinical lumbar polyradiculopathy in aged domestic, laboratory, and exotic mammalian species--a light and selected electron microscopic study. | lumbar polyradiculopathy, characterized by ballooning myelin sheaths and axonal distortion, was documented in multiple, aged, domestic, laboratory, and exotic mammalian species. animals studied that exhibited this nerve rootlet change included the goat, sheep, pig, white-tailed deer, gerbil, vole, ferret, beaver, hedgehog, chinchilla, north chinese leopard, lion, cheetah, mountain lion, llama, east african eland, uganda giraffe, polar bear, and drill. ultrastructurally, lumbar nerve rootlets fro ... | 1989 | 2766747 |
| scanning electron microscopic study of the red pulp of ferret spleen. | scanning electron microscopy of the red pulp of ferret spleen showed areas of relatively wide splenic cord and rather poorly developed splenic sinuses of two different types. the inner aspect of most sinuses was covered with rod-shaped cells running in the longitudinal direction of the sinus. stomata of these sinuses were recognized between the rod-like cells in a relatively regular lattice-like arrangement. the lining of other sinuses showed characteristics of the poorly differentiated sinuses, ... | 1989 | 2769147 |
| blocking of pregnancy in mice by immunization with anti-idiotype directed against monoclonal anti-progesterone antibody. | passive transfer of monoclonal anti-progesterone antibodies shortly after mating blocks the onset of pregnancy in different species (mouse, rat, and ferret). here we report that balb/c mice can be actively immunized against progesterone, and hence against pregnancy, by means of rabbit anti-idiotypic antibodies specific for a mouse monoclonal anti-progesterone antibody, db3. some of the anti-idiotypic antibodies reacted with the steroid-combining site on the db3 molecule. in response to repeated ... | 1989 | 2780564 |
| direct measurement of changes in intracellular calcium transients during hypoxia, ischemia, and reperfusion of the intact mammalian heart. | in studies of ischemia and reperfusion, a major experimental problem has been the inability to measure intracellular ionized calcium ([ca2+]i) in the intact heart. we have developed a new approach in which the bioluminescent calcium indicator aequorin is used to measure [ca2+]i in the isolated, coronary-perfused ferret heart. aequorin is loaded into subepicardial myocytes of the left ventricle, and the signals are recorded simultaneously along with isovolumic left ventricular (lv) pressure at a ... | 1989 | 2791218 |
| medical and surgical management of esophageal foreign body in a ferret. | a ferret was examined because of anorexia, repeated episodes of regurgitation, and subsequent dehydration. radiography had revealed a radiodense midesophageal foreign body. results of endoscopy of the esophagus, however, could not confirm the diagnosis. contrast radiography revealed esophageal perforation, with subsequent penetration of the foreign body into the right pleural space, causing pleural effusion. surgical repair of the esophagus was performed, and a gastrostomy feeding tube was inser ... | 1989 | 2793582 |
| lung volumes after an increase in lung distension in pneumonectomized ferrets. | to investigate the role of lung distension in compensatory lung growth, the right lung of each of 21 adult male ferrets was replaced with a silicone rubber balloon filled with mineral oil. three to thirteen weeks after surgery, the oil was removed through a subcutaneous port. lung volumes were measured serially until 3-6 wk after balloon deflation. with pneumonectomy the total lung capacity (tlc) decreased to less than 50% of the preoperative value and remained essentially unchanged while the ba ... | 1989 | 2793743 |
| responses of vagal efferent fibres to stimulation of gastric mechano- and chemoreceptors in the anaesthetized ferret. | the involvement of gastric tension receptors and mucosal chemoreceptors in vagal reflexes was assessed directly by recording single efferent fibres from the cervical vagus nerve in the urethane anaesthetised ferret. 32/39 fibres responded to distension of the gastric corpus, mainly with excitation of firing, 24/39 fibres responded to antral distension, with a higher proportion showing a reduction in firing. fifty-seven percent of fibres showed a convergent input from corpus and antrum. the magni ... | 1989 | 2794343 |
| the consequences of simulated ischaemia on intracellular ca2+ and tension in isolated ferret ventricular muscle. | 1. in order to study cellular events occurring in ischaemia, we have developed a method for simulating ischaemia in an isolated papillary muscle. muscles were suspended in a chamber and changed from conventional superfusion with tyrode solution to gas perfusion with 95% n2/5% co2 (n2 gas perfusion), thus simultaneously stopping oxygenation and flow. surface cells of the preparation were injected with the photoprotein aequorin in order to monitor intracellular free calcium concentration [( ca2+]i ... | 1989 | 2795481 |
| ultrastructure of the ferret sublingual gland. | the sublingual glands of 2 male and 2 female adult ferrets were examined using electron microscopy. the secretory end piece consisted of mucous tubules, serous and mixed acini. the mucous cells showed two different types of granules. the serous cells contained electron-dense secretory granules. the duct system entirely comprised excretory ducts. | 1989 | 2801007 |
| comparative effects of bepridil, its quaternary derivative cerm 11888 and verapamil on caffeine-induced contracture in ferret hearts. | 1. the effects of bepridil, its quaternary derivative: cerm 11888 (methyl-pyrrolidinium bromide) (10(-7)-10(-5) m), and verapamil (10(-7)-10(-6) m) were compared on caffeine-induced contracture of isolated ventricular trabeculae of the ferret. 2. bepridil diminished the amplitude of contracture in a concentration-dependent fashion, and this effect was significantly different from that of cerm 11888 which, like verapamil, only reduced the amplitude at the highest concentration used. 3. bepridil ( ... | 1989 | 2804541 |
| effects of ryanodine on contractile performance of intact length-clamped papillary muscle. | extent, time course, and underlying mechanisms of the negative inotropic effect of ryanodine were examined in 22 length-clamped ferret right ventricular papillary muscles paced 12/min at 25 degrees c. after 60 minutes of exposure to 5 microm ryanodine a new steady state was attained with developed forces averaging 10-15% of maximum twitch force. ryanodine does not pharmacologically excise the sarcoplasmic reticulum (sr) in this preparation. ryanodine does not appreciably inhibit the ability of t ... | 1989 | 2805244 |
| binding of staphylococci to mucus in vivo and in vitro. | the association of staphylococcus aureus, staphylococcus epidermidis, and staphylococcus saprophyticus with tissues of the upper respiratory tract were compared by using an in vivo ferret model. ferrets were challenged intranasally with a 1-ml volume of radiolabeled staphylococci (3 mg [dry weight]), were allowed to clear the bacteria in vivo for 90 min, and were sacrificed. tissues from the right nasal fossa were harvested and processed for radioassay or histology. of the recoverable staphyloco ... | 1989 | 2807545 |
| development of glial cells in the cerebral wall of ferrets: direct tracing of their transformation from radial glia into astrocytes. | coronal sections of the cerebral wall from developing ferrets (newborn to adult) were double-stained with antibodies to vimentin and glial fibrillary acidic protein (gfap). at birth, the dominant glial population was radial glia and these cells labeled only for vimentin. a small population of immature astrocytes in the cortical plate was double labeled for gfap and vimentin. in successive days, the number of vimentin-positive radial glia gradually decreased and they disappeared entirely at about ... | 1989 | 2808761 |
| the ferret as a model for vasomotor biocompatibility testing of medical devices. | | 1989 | 2811290 |
| ferret model for acquired subglottic stenosis. | researchers continue to look for an improved animal model for the study of acquired subglottic stenosis. this report describes a ferret model that reliably produces 40% to 60% stenosis with a method analogous to the pathophysiology of prolonged endotracheal intubation. unlike some previously developed animal models, this model has a low morbidity and a perioperative mortality of less than 5%. ferrets are small, hardy animals that are inexpensive and easy to house, handle, and anesthetize. they a ... | 1989 | 2817685 |
| comparisons of feline panleukopenia virus, canine parvovirus, raccoon parvovirus, and mink enteritis virus and their pathogenicity for mink and ferrets. | parvoviruses from mink (mink enteritis virus [mev]), cats (feline panleukopenia virus [fpv]), raccoons (raccoon parvovirus [rpv]), and dogs (canine parvovirus [cpv]) were compared. restriction enzyme analysis of the viral replicative-form dna revealed no consistent differences between fpv and rpv isolates, but cpv and mev isolates could be distinguished readily from other virus types. feline panleukopenia virus, rpv, and mev, but not cpv, replicated to high titers in mink. however, on the first ... | 1987 | 2823648 |
| passive serum antibody causes temporary recovery from influenza virus infection of the nose, trachea and lung of nude mice. | balb/c normal and nude mice were infected with a non-lethal mouse-passaged a/pc/1/73 (h3n2) influenza virus in order to assess the role of t cells on the course of disease of the nose, trachea and lung. the tracheal epithelium of both mouse strains was desquamated by 3 days after infection. although normal regeneration began, nude mice never completed that regeneration whereas normal mice had fully regenerated tracheas by day 14. this failure to complete the recovery was also evident from the co ... | 1988 | 2832312 |
| subacute toxicity of diethylstilboestrol and hexoestrol in the female rat, and the effects of clomiphene pretreatment. | two groups, each of ten female rats, were orally dosed with the synthetic oestrogens diethylstilboestrol (des; 6 mg/kg day) and hexoestrol (60 mg/kg/day) for 6 wk. a further group of ten animals received clomiphene citrate (2 mg/kg/day) and des (6 mg/kg/day), while two groups, each of ten animals, acted as controls. one animal treated with des died within the 42-day study period. its death was associated with a bleeding disorder related to severe liver damage. the remaining treated animals showe ... | 1988 | 2835297 |
| effects of cyclo- and lipoxygenase inhibitors on hypoxic vasoconstriction in isolated ferret lungs. | to evaluate the role of leukotrienes in hypoxic pulmonary vasoconstriction, we measured steady-state pressor responses to graded hypoxia in isolated ferret lungs perfused with autologous blood containing 0.001, 0.03, 1, or 3 mm nordihydroguaiaretic acid (ndga), 1 mm bw 755c, or 0.02-0.05 mm indomethacin. untreated lungs served as controls. perfusate concentrations of thromboxane b2 and 6-ketoprostaglandin f1 alpha, measured by radioimmunoassay, were markedly reduced in all treated lungs, indicat ... | 1988 | 2835351 |
| functional evidence in diseased human heart fibers for multiple sensitivities of the inotropic ouabain receptor na+,k+-atpase (nka). | through contributions of many investigators from our group at the university of cincinnati medical center, several facts emerged. it is clear that the rat ventricle has 2 inotropic sensitivities to ouabain (grupp et al., 1981), related to high and low affinity ouabain binding sites (adams et al., 1982) and the presence of an appropriate abundance of alpha and alpha + catalytic subunits of nka (young and lingrel, 1987). the rat atria which demonstrate only the low affinity inotropic response (gru ... | 1988 | 2837772 |
| alterations in the course of and histopathologic response to influenza virus infections produced by enflurane, halothane, and diethyl ether anesthesia in ferrets. | alterations in the course of and histopathologic response to influenza viral infections by halothane, enflurane, and diethyl ether anesthesia were evaluated in ferrets. there were no significant differences in the incidence and duration of lethargy, pyrexia, rhinorrhea, or sneezing in infected animals given one of the three anesthetic agents under investigation, compared with those receiving no anesthesia. there were no differences in lung pathology in infected animals given one of the three ane ... | 1988 | 2837925 |
| modulation of cholinergic neurotransmission by vasoactive intestinal peptide in ferret trachea. | we studied the effect of vasoactive intestinal peptide (vip) on the contractile responses to electrical field stimulation (efs) in isolated ferret tracheal segments. vip did not change resting tension up to 2 x 10(-7) m, but it showed a biphasic effect on the responses to efs. in concentrations up to 10(-9) m, vip potentiated the response; at higher concentrations vip reduced responses. thus, at a concentration of 10(-9) m, vip decreased the mean (+/- se) log efs frequency, producing 50% of maxi ... | 1988 | 2841273 |
| auditory brainstem of the ferret: effects of unilateral cochlear lesions on cochlear nucleus volume and projections to the inferior colliculus. | unilateral lesions of the right cochlea were made in ferrets aged postnatal day (p)12 to p93. the extent of the lesions was assessed by counting remaining hair cells and ganglion cells in midmodiolar sections through the lesioned cochleas and by comparison with a sample of unlesioned cochleas. the neural effects of the lesions were assessed by measuring the volume of each cochlear nucleus (cn) and by counting the number of neurons in each cn that were retrogradely labeled following injections of ... | 1988 | 2843582 |
| propagation and quantitation of animal herpesviruses in eight cell culture systems. | a comparative study was carried out to determine the relative sensitivities of eight different cell culture systems to six different herpesviruses of animals. the cells used were: ofl (ovine fetal lung), ml (mink lung), fk (ferret kidney), ptk-2 (potoroo kidney), tek (turkey embryo kidney), ed (equine dermal), bt (bovine turbinate), and pk15 (porcine kidney). the viruses tested were: prv (pseudorabies) of swine, cphv (caprine herpesvirus), ibrv (infectious bovine rhinotracheitis virus), dn-599 s ... | 1988 | 2846231 |
| serum cortisol radioimmunoassay values in the normal ferret and response to acth stimulation and dexamethasone suppression tests. | cortisol values were obtained from 39 ferrets, mustela putorius furo, by using a commercial radioimmunoassay. sera from 25 males (18 intact, 7 neutered) and 14 females (7 intact, 7 spayed) were assayed. resting serum cortisol values ranged from 0.13 to 2.70 micrograms/dl for males (mean = 0.93 +/- 0.63 micrograms/dl), and 0.55 to 1.84 micrograms/dl for females (mean = 0.86 +/- 0.29 microgram/dl). the resting cortisol values of both males and females were comparable to those of the cat (1.0 to 3. ... | 1988 | 2846957 |
| the anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist brl 43694. | in ferrets, the selective 5-hydroxytryptamine (5-ht) 5-ht3 receptor antagonist brl 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v.) before and after cisplatin dramatically reduced or abolished the severe cisplatin-induced vomiting. brl 43694 also substantially reduced the vomiting induced by cyclophosphamide:doxorubicin, and prevented the trimelamol-induced emesis. the severe emesis caused by whole body exposure to x- ... | 1988 | 2851311 |
| two molecular forms of na+,k+-atpase in the ferret heart and developmental changes in digitalis sensitivity. | | 1988 | 2851821 |
| cardiac na+,k+-atpase isoenzymes: sensitivity to prednisolone bisguanylhydrazone. | prednisolone-3,20-bisguanylhydrazone (pbgh), a steroid derivative, has been shown to inhibit na+,k+-atpase isolated from guinea-pig heart or kidney in concentrations significantly lower than those required to inhibit the enzyme obtained from other sources. because na+,k+-atpases obtained from guinea-pig heart or kidney are predominantly of the alpha isoform, the hypothesis that pbgh selectively inhibits the alpha isoform over alpha (+) isoform of the enzyme was tested. sodium dodecylsulfate poly ... | 1988 | 2854075 |
| rapid regulation of the 'second inward current' by intracellular calcium in isolated rat and ferret ventricular myocytes. | 1. single cells were isolated from the ventricles of ferret and rat hearts. cells were voltage clamped using a single conventional microelectrode. membrane voltage, membrane currents and cell length were monitored. 2. the current elicited by decreasing the membrane potential from a holding potential of -40 or -45 mv to potentials more positive than -20 mv was abolished by d600, by cd2+ and by removal of ca2+ from the cell superfusate. this current activated within 20 ms and inactivated over seve ... | 1988 | 2855743 |
| variability in milk composition of the domestic ferret (mustela putorius). | ferret milk composition was analyzed among individuals, over time, and across teat pairs. females differed in fat, protein, and lactose concentrations. protein and fat concentrations varied over the course of lactation. lactose was the only measured component which differed across teat pairs. | 1985 | 2863046 |
| differential inotropic actions of ethmozine and ethacizin (diethylamine analog of ethmozine). | the direct inotropic actions of ethmozine and of its diethylamine analog, ethacizin, were studied in the presence of muscarinic and beta-adrenoreceptor blockade in 12 ferret right ventricular papillary muscles. in each muscle ethmozine caused a small but consistent and significant (p less than 0.05) increase in contractile performance, whereas ethacizin significantly (p less than 0.05) diminished contractility. although both phenothiazines are fast channel blockers, it appears that the net posit ... | 1986 | 2869671 |
| neural control of jejunal and ileal motility and transmural potential difference in the ferret. | the aim of the present study was to examine the vagal control of motor activity and transmural potential difference in the anaesthetized ferret jejunum and ileum in vivo. the data suggest that in the jejunum fluctuations in transmural potential difference occur secondary to spontaneous bursts of contractions and both are controlled by activity in the vagus nerve. however, in the ileum, spontaneous contractile activity and transmural potential difference are not under the tonic influence of the v ... | 1986 | 2870789 |
| regulation of salt and water transport across airway mucosa. | effective mucociliary clearance of secretions by airway mucosa requires efficient ciliary beating. the structure of airway secretions provides for this requirement by having a viscous mucous layer touched underneath and propelled by ciliary tips, while the rest of the cilium is surrounded by a serous fluid layer. the regulation of the latter layer is thought to be a function of mucosal epithelial cells capable of active ion transport. mammalian medium-sized bronchi actively absorb sodium, wherea ... | 1986 | 2872993 |
| the effects of cyanide on intracellular ionic exchange in ferret and rat ventricular myocardium. | the effects of cyanide on ca2+ exchange in isolated ventricular myocytes and on the intracellular concentrations of ca2+, na+ and h+ have been investigated to assess the contribution that mitochondria might play in cellular ca2+ metabolism. ionic levels were measured with ion-selective electrodes. kcn (2.5 mm) inhibited a component of ca2+ exchange in myocytes that could be attributed to mitochondrial exchange, but was without effect on non-mitochondrial ca2+ exchange. nacn (2.5 mm) caused a tra ... | 1987 | 2884664 |
| a small proportion of cholinergic neurones in the nucleus basalis magnocellularis of ferret appear to stain positively for tyrosine hydroxylase. | the immunofluorescence and peroxidase-antiperoxidase methods for immunohistochemistry were used to show that a small number of neurones in the nucleus basalis magnocellularis of ferret stain positively for what appears to be tyrosine hydroxylase, a marker for catecholaminergic neurones. with a double immunocytochemical staining method, it was confirmed that the tyrosine hydroxylase-like immunoreactivity is localized in neurones that also stain strongly for choline acetyltransferase. | 1987 | 2886187 |
| a permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret. | 1. the role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized ferret. 2. antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an intra-antral pressure of 0.27 +/- 0.11 kpa) by a vagal-dependent mechanism as indicated by the attenuated response seen during vagal blockade by cooling. atropine (1 mg/kg) abolished the antral response to distension. 3. in vagotomized ani ... | 1986 | 2887649 |
| effect of alpha-adrenoceptor stimulation of isolated canine, ferret and guinea pig airways. | functional responses and subtypes of alpha-adrenoceptors in canine trachealis smooth muscle were investigated using the agonists; epinephrine, norepinephrine, sk&f 89748 (alpha 1-selective) and bht-933 (alpha 2-selective) in the presence of a beta-adrenoceptor antagonist. tissue contractility to these agonists was in the range of 16 to 46% of the maximum response to serotonin. sk&f 89748 was most effective in canine airways; however, the contractions could be abolished by methysergide. neither p ... | 1987 | 2888935 |
| direct and relayed projection of periodontal receptor afferents to the cerebellum in the ferret. | field potentials in the cerebellar cortex of the ferret have been studied in response to stimulation of alveolar, muscular and cutaneous branches of the trigeminal nerve. responses from the alveolar nerves are unusual in their very short latency. evidence based on latency analysis, frequency following and comparison with other well-known inputs supports the view that the earliest field potentials are due to direct, unrelayed afferents, which terminate as mossy fibres. there is, in addition, a mo ... | 1987 | 2889211 |
| emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs. | the intravenous injection of cisplatin in the ferret caused a consistent emetic (vomiting/retching) response. emesis induced by cisplatin was abolished by the 5-hydroxytryptamine (5-ht) m-receptor antagonists ics205-930, zacopride, dazopride and metoclopramide. the neuroleptic agents haloperidol, fluphenazine, domperidone, sulpiride and tiapride also antagonized emesis induced by cisplatin but only a proportion of the animals were completely protected and diazepam and prednisolone only reduced t ... | 1987 | 2890117 |
| catecholaminergic properties of cholinergic neurons and synapses in adult rat ciliary ganglion. | parasympathetic neurons of the ciliary ganglion are innervated by preganglionic cholinergic neurons whose cell bodies lie in the brain stem; the ganglion cells in turn provide cholinergic innervation to the intrinsic muscles of the eye. noradrenergic innervation of the iris is supplied by sympathetic neurons of the superior cervical ganglion. using immunocytochemical and histochemical techniques, we have examined the ciliary ganglion of adult rats for the expression of cholinergic and noradrener ... | 1987 | 2890721 |
| catecholaminergic horizontal and amacrine cells in the ferret retina. | enzymes involved in the synthesis of catecholamines were detected in amacrine and what appeared to be a specific class of horizontal cells in the ferret retina. antisera directed against the enzymes tyrosine hydroxylase (th), which converts tyrosine to dopa, and phenylethanolamine n-methyl-transferase (pnmt), which converts norepinephrine to epinephrine, were used with conventional immunohistochemical techniques. a population of perikarya located at the outer margin of the inner nuclear layer (i ... | 1987 | 2891801 |
| overlap in the distribution of cholinergic and catecholaminergic neurons in the upper brainstem of the ferret. | the distribution of catecholaminergic and cholinergic neurons in the upper brainstem of the ferret were mapped by staining immunohistochemically two adjacent series of sections of brainstem for tyrosine hydroxylase and choline acetyltransferase, respectively. as in other species, large numbers of tyrosine-hydroxylase-positive neurons are localized in the ventral tegmental area (a10), the substantia nigra (a9), and in a8. tyrosine-hydroxylase-positive neurons in the dorsolateral pontine tegmentum ... | 1987 | 2892867 |
| effect of almitrine bismesylate on breathing pattern during hypoxia/hypercapnia in rats and ferrets. | 1. ventilatory measurements and functional residual capacity (frc) were recorded from anaesthetized rats and ferrets using a whole body plethysmograph. simulation of aspects of human chronic obstructive airways disease (coad) was attempted by making animals acutely hypoxic or hypoxic and hypercapnic by causing them to breath appropriate gas mixtures or by increasing the tracheal resistance or dead-space. some chronically hypoxic rats, which have muscularized pulmonary arterioles similar to coad ... | 1987 | 2896080 |
| vasodilator response to dopamine in the ferret pulmonary circulation. | 1. the isolated perfused lung of the ferret was used to study the effects of dopamine receptor agonists and antagonists. under constant flow, a fall in pulmonary artery pressure reflects a vasodilator response. since tone is normally low, agonists were given during hypoxic pulmonary vasoconstriction to enable detection of dilator responses. 2. vasodilator responses were produced by bolus doses of dopamine over the range 0.1 to 5.0 micrograms kg-1, and by the selective da1 agonist sk&f 38393 (1-p ... | 1988 | 2900036 |
| reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. | the involvement of 5-hydroxytryptamine (5-ht) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine. pretreatment with reserpine (5 mg/kg, 24 hr), fenfluramine (5 mg/kg, 4 days) or para-chlorophenylalanine (100 or 400 mg/kg, 4 days) antagonised cisplatin-induced emesis. all treatments reduced the levels of 5-ht in the area postrema and at other cerebral sites, but whilst this action was relatively selective for small doses of para ... | 1988 | 2905784 |
| identification of 5-ht3 recognition sites in the ferret area postrema. | the 5-ht3 receptor antagonist [3h]zacopride was used to identify 5-ht3 recognition sites in the ferret area postrema. specific binding was determined by the inclusion of the 5-ht3 receptor antagonist brl 43694 in the incubation media, and was shown to be much higher in the area postrema than in other brain regions. the increased binding in the area postrema may reflect either a greater number of binding sites, a higher affinity for such sites, or both. the results indicate that 5-ht3 recognition ... | 1988 | 2907019 |
| continuous monitoring of the movements of erupting and newly erupted teeth of limited growth (ferret mandibular canines) and their responses to hexamethonium. | the rates of these eruption-like movements were high and were consistent with reports that eruption is fastest at the time of emergence into the mouth. once the tooth had attained its initial functional position, there was a significant reduction in the rates. following administration of the hypotensive agent, hexamethonium, the emerging tooth showed a significant decrease in eruption rates. however, no change was observed for the tooth which had attained its initial functional position. these f ... | 1988 | 2908265 |
| load responsiveness of protein synthesis in adult mammalian myocardium: role of cardiac deformation linked to sodium influx. | exposure of adult mammalian myocardium to increased hemodynamic loads augments cardiac protein synthesis, ultimately leading to hypertrophy of the affected chamber. this established relationship between loading conditions and protein synthesis was examined in terms of two questions. first, is there a basic difference between the anabolic effect of a passive load imposed on diastolic myocardium and that of an active load generated by systolic myocardium? this issue was addressed by measuring [3h] ... | 1989 | 2909303 |
| the deoxyglucose method in the ferret brain. i. methodological considerations. | in the brain of the anesthetized ferret, the 2-deoxyglucose (2-dg) transfer rate constants required to determine cerebral glucose utilization by the deoxyglucose method were calculated from regional gray matter time-radioactivity curves measured for 180 min after tracer injection. results suggest that loss of metabolized tracer from brain occurs at a rate of about 1%/min for the first 180 min after injection if the rate constant of the rate-limiting step for loss of metabolized tracer (k4*) repr ... | 1989 | 2910895 |
| the deoxyglucose method in the ferret brain. ii. glucose utilization images and normal values. | to measure cerebral glucose utilization with the autoradiographic deoxyglucose method, the tracer transfer rate constants and lumped constants must be known. 2-deoxyglucose (2-dg) and fluorodeoxyglucose (fdg) constants were determined in 18 gray and white matter brain structures of the anesthetized ferret. the ferret is a domestic carnivore particularly suitable for deoxyglucose studies because of its small brain size and low body weight. the average gray matter rate constants for tracer transfe ... | 1989 | 2910896 |
| delayed neurotoxic effects of tri-o-tolyl phosphate in the european ferret. | the development of organophosphorus-induced delayed neurotoxicity (opidn) was studied in the european ferret (mustela putorius furo). a single oral or dermal dose of 250, 500, or 1000 mg tri-o-tolyl phosphate (totp)/kg body weight was administered to adult male ferrets. corn oil served as the vehicle in the oral test and 95% ethanol was the vehicle in the dermal test. at 48 h posttreatment, half the animals in each group were killed by cervical dislocation for assessment of whole-brain neuropath ... | 1989 | 2913334 |
| the cholinergic input to the superficial layers of the superior colliculus: an ultrastructural immunocytochemical study in the ferret. | the cholinergic innervation of the superficial layers of the ferret's superior colliculus was investigated with a combination of electron microscopy and choline acetyltransferase immunohistochemistry. cholinergic boutons in the superficial layers of the superior colliculus possess spherical vesicles and make predominantly asymmetrical synapses onto the profiles of small dendrites, as do the terminals of cortical and retinal axons. in most areas of the brain studied so far, cholinergic terminals ... | 1989 | 2914209 |
| brain stem topography of vagus nerve to the greater curvature of the stomach. | if preganglionic vagus nerve fibers enter the stomach via all of its neurovascular bundles, then proximal gastric vagotomy that divides only the bundles along the lesser curvature of the stomach neglects a potential source of innervation to the parietal cells. to determine whether or not these bundles contained preganglionic efferent vagal nerve fibers, horseradish peroxidase was applied to the central cut end of selected neurovascular bundles along the greater curvature of the stomach in rats a ... | 1989 | 2915536 |
| simultaneous measurements of action potential duration and intracellular atp in isolated ferret hearts exposed to cyanide. | shortening of the cardiac action potential during ischemia and anoxia is likely to contribute to the decline in contractility that occurs under such conditions. it has been hypothesized that a decrease in the intracellular atp concentration ([atp]i) underlies the changes in the action potential. the recently discovered potassium channel activated at low atp concentrations might provide the link between action potential shortening and low [atp]i. however, it has yet to be shown that [atp]i falls ... | 1989 | 2917382 |
| a comparison of experimental visceral leishmaniasis in the opossum, armadillo and ferret. | visceral leishmaniasis is a severe, chronic protozoal disease of humans and animals. although chemotherapeutic agents are available for the treatment of this disease, problems such as drug toxicity, drug ineffectiveness and drug resistance of the parasite are responsible for treatment failures. to determine whether a drug is a potential antileishmanial agent, screening tests are performed using in vitro and in vivo models. subsequently, a study using an appropriate animal model is performed to c ... | 1989 | 2918684 |
| na-ca exchange in ferret red blood cells. | ferrets have high na (140 mmol/l) red blood cells. to determine whether ferret red cells had a na-ca exchange system, na effluxes via the na + k + 2cl cotransrpoter and ca effluxes via the ca pump had to be inhibited. this was accomplished by replacing cell chloride with nitrate and by loading the cells with vanadate that inhibits the ca pump. under these conditions, extracellular na (naout) inhibited ca influx. intracellular na (nain) was required for the large ca influx as replacement of na wi ... | 1989 | 2919665 |
| modality specific type 2 theta production in the immobile rat. | the purpose of the present study was to compare the relative effectiveness of stimulation of different sensory modalities in eliciting type 2 theta in the rat in the presence or absence of a ferret. visual, auditory, and tactile stimuli were presented to rats in both conditions. tactile stimulation produced more movement than either visual or auditory stimuli when the ferret was present. in both conditions, however, more type 2 theta was observed in response to tactile or visual stimulation than ... | 1989 | 2923663 |
| failure of fertilization following abbreviated copulation in the ferret (mustela putorius furo). | in the first experiment, copulations in 10 domestic ferrets were interrupted 5 minutes after penetration. ten control females were bred without interruption to the same males. both control and experimental animals were rebred in the same manner to the same males 24 hours later. sperm were present in all postcoital washes. we allowed all females from the first experiment to proceed to their expected date of parturition. all females who had been interrupted during copulation failed to conceive, wh ... | 1989 | 2926363 |
| comparative anatomy of melanin pigment in the stria vascularis. evidence for a distinction between melanocytes and intermediate cells in the cat. | although corti in 1851 first described the presence of cochlear pigmentation in the stria vascularis (sv) of "very old" cats, modern studies have failed to find pigment consistently in the feline stria. while the variable presence of pigment in the feline sv would appear to contrast with this structure's uniform pigmentation in other mammalian species, variability in both the distribution and abundance of inner ear pigment has rarely been studied in any species. in the present study, the sv was ... | 1989 | 2929316 |
| altered calcium handling in experimental pressure-overload hypertrophy in the ferret. | the purpose of this study was to evaluate the relationship between changes in the intracellular handling of free, ionized calcium and the functional alterations that occur in cardiac hypertrophy. we developed a model of right ventricular pressure-overload hypertrophy in the ferret by critical banding of the pulmonary artery; this method produced significant degrees of hypertrophy within 1-3 months of surgery. we removed papillary muscles, 1 mm or less in diameter, from ferrets with cardiac hyper ... | 1985 | 2933178 |
| regional myocyte size in compensated right ventricular hypertrophy in the ferret. | the effect of pressure-induced right ventricular hypertrophy on regional myocyte size and shape and regional myocardial wet weight was studied by comparing 20 ferrets which underwent pulmonary artery banding at a weanling age to 19 non-operated siblings. using isolated myocyte preparations from six myocardial regions in 10 banded and seven non-banded ferrets, a 60% increase in cell volume in the right ventricular outflow tract and the right ventricular free wall was shown to be due primarily to ... | 1985 | 2933527 |
| establishment of central nervous system infection by canine distemper virus: breach of the blood-brain barrier and facilitation by antiviral antibody. | morphologic, immunologic and virologic data implicating antiviral antibody in promoting entry of canine distemper virus (cdv) into brain and reticuloendothelial tissues are reviewed. infection of central nervous system (cns) endothelium precedes invasion of virus-positive and -negative leukocytes into virchow-robin spaces and central nervous system (cns) parenchyma by 1-3 days. platelets are implicated in initiation of endothelial infection in that: cdv-infected dogs are thrombocytopenic; platel ... | 1987 | 2963430 |
| antiemetic properties of the 5ht3-receptor antagonist, gr38032f. | gr38032f is a highly selective 5ht3-receptor antagonist which inhibits vomiting induced by cisplatin, cyclophosphamide or x-radiation in the ferret. since cisplatin selectively increased the levels of 5ht and 5hiaa in the intestinal mucosa, a possible site of the antiemetic action of gr38032f may be on 5ht3-receptors on vagal afferents in the small intestine. the potent antiemetic action of gr38032f should be of clinical value in reducing the nausea and vomiting associated with radiotherapy or c ... | 1987 | 2964267 |
| dracunculus insignis: experimental infection in the ferret, mustela putorius furo. | the laboratory study of dracunculiasis has suffered from the lack of a suitable, readily available animal model. we have been able to experimentally infect ferrets. mustela putorius furo, with the north american dracunculid, dracunculus insignis. ferrets were inoculated with 75 to 100 infective larvae and were necropsied 90 to 240 days later. guinea worms were recovered from 10 (56%) of 18 ferrets. a total of 44 worms were recovered, for an average of 4.4 worms per infected ferret. gravid female ... | 1988 | 2973492 |
| bmy-25801, an antiemetic agent free of d2-dopamine receptor antagonist properties. | bmy-25801, 4-amino-5-chloro-n-[2-(diethylamino)ethyl]2-(1-methyl-2-oxopropoxy ) benzamide, a new antiemetic agent free of d2-dopamine receptor antagonist properties, was effective against emesis induced by cytostatic agents (cisplatin, cyclophosphamide and doxorubicin) and total body radiation in the ferret. it also was effective against cisplatin-induced emesis in the dog; however, it was inactive against emesis caused by apomorphine and hydergine in the same species. in terms of activity profi ... | 1988 | 2978041 |