Publications

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hyphae of coccidioides immitis in tissues of the human host. 195413180869
preliminary studies on artificial active immunization of guinea pigs against respiratory challenge with coccidioides immitis. 195413189065
viability of coccidioides immitis. 1. isolation from a seven-month-old sealed microscope slide. 195413192347
a method for cultural identification of coccidioides immitis. 195413207065
mycelial forms of coccidioides immitis in sputum and tissues of the human host. 195513239023
a new fungicide for coccidioides immitis. 195513239340
in vitro production of the spherule phase of coccidioides immitis. 195513251984
comparative histochemical studies on coccidioides immitis and haplosporangium parvum. 195513252254
isolation of coccidioides immitis from spinal fluid by molecular filter membrane technic. 195513258532
coccidioides immitis in the soil of the southern san joaquin valley. 195613282896
growth of spherules of coccidioides immitis in a chemically defined liquid medium. 195513289883
[spondylitis caused by coccidioides immitis]. 195513297435
the growth of coccidioides immitis in the granuloma pouch of the rat with the development of hyphae and other forms. 195613319809
the inhibitory effect of peptone on the sporulation of three strains of coccidioides immitis. 195613327230
atypical cultures of coccidioides immitis. 195613339731
relationship of the in vivo form of coccidioides immitis to virulence. 195613346127
the virulence and infectivity of twenty-seven strains of coccidioides immitis. 195613362231
survival of coccidioides immitis under controlled conditions of temperature and humidity. 195613362665
a cytological study of coccidioides immitis by electron microscopy. 195613376509
atypical tissue forms of coccidioides immitis resembling blastomyces. 195613381708
budding and mycelium formation in the life cycle of coccidioides immitis rixford and gilchrist, 1896-in vivo, with a review of the literature. 195613387626
effect of physico-chemical environment of spherulation of coccidioides immitis in a chemically defined medium. 195613398364
some cytological observations on the effect of ribonuclease on coccidioides immitis. 195713405013
[action in vitro of cortisone on a strain of coccidioides immitis (blastomycoides mataeuropeus castellani 1933)]. 195613412851
an evaluation of amphotericin b in vitro and in vivo in mice against coccidioides immitis and candida albicans, and preliminary observations concerning the administration of amphotericin b to man. 195713429161
fountain pen ink staining of coccidioides immitis in wet and fixed clinical specimens. 195713430093
the comparison of four strains of coccidioides immitis with diverse histories. 195713430697
ecological factors of the geographic distribution of coccidioides immitis. 195713438738
a technique for the safe handling of coccidioides immitis cultures. 195713439280
histopathologic reactions of the yolk sac tissue of embryonated hen's eggs to coccidioides immitis. 195713458335
effect of surface active agents on endosporulation of coccidioides immitis in a chemically defined medium. 195713462968
the geographic distribution of coccidioides immitis and possible ecologic implications. 195813510095
nutritional requirements for the growth and arthrospore formation of coccidioides immitis. 195813513595
the selective and differential effects of cycloheximide on many strains of coccidioides immitis. 195813520665
the selective and differential effects of cycloheximide on many strains of coccidioides immitis. 195813529801
biochemical changes occurring during growth of coccidioides immitis in a defined medium. 195813549375
the development of strains of candida albicans and coccidioides immitis, which are resistant to amphotericin b. 195813637860
antifungal agent.from the soil of the san joaquin valley a fungus has been isolated, an extract of which inhibits the growth of coccidioides immitis on sabouraud's medium. an acute toxicity study in mice indicates a certain tolerance of the extract. tentative identification indicates that the fungus is a penicillium.196113725895
approaches to the physiology of coccidioides immitis. 196013732667
studies of antigens from young mycelia of coccidioides immitis. 196113732669
virulence assay of coccidioides immitis in embryonated eggs. 196113742713
immunogenicity of spherule-endospore vaccines of coccidioides immitis for mice. 196113761478
purification of the spherule-endospore phase of coccidioides immitis. 196113761479
studies of the growth and metabolism of coccidioides immitis. 196013763315
x-ray irradiation of coccidioides immitis arthrospores: survival curves and avirulent mutants isolated. 196013823726
the pathology of coccidioides immitis in the macaca mulatta. 196113870259
immunization of mice against coccidioidomycosis.converse, j. l. (u. s. army chemical corps, frederick, md.), m. w. castleberry, a. r. besemer, and e. m. snyder. immunization of mice against coccidioidomycosis. j. bacteriol. 84:46-52. 1962-the observed lower virulence of coccidioides immitis arthrospores of the m-11 strain compared with the cash strain was ascribed to the lower ability of the m-11 spores to invade the lungs and brain. endospores of strain m-11, grown in synthetic medium, were equally as virulent by the intraperitoneal route as ...196213881007
pathogenesis of coccidioides immitis in monkeys.converse, j. l. (u. s. army chemical corps, fort detrick, frederick, md.), e. p. lowe, m. w. castleberry, g. p. blundell, and a. r. besemer. pathogenesis of coccidioides immitis in monkeys. j. bacteriol. 83:871-878. 1962.-respiratory exposure to arthrospores from the submerged growth of coccidioides immitis, strain cash, in liquid medium resulted in similar pathogenesis in monkeys to that of strain silveira arthrospores harvested from solid medium. infectivity of 100% was noted with doses of 50 ...196213881008
studies on the survival characteristics of the parasitic phase of coccidioides immitis with comments on contagion. 196213895271
studies on coccidioides immitis. i. a simple medium for in vitro spherulation.northey, w. t. (arizona state university, tempe) and l. d. brooks. studies on coccidioides immitis. i. a simple medium for in vitro spherulation. j. bacteriol. 84:742-746. 1962.-a simple medium is suggested which markedly enhances the in vitro conversion of the dimorphic fungus coccidioides immitis. the principal component of this medium is edamine, an enzymatic digest of lactalbumin. the arthrospore-spherule conversion was accomplished in as little as 12 hr when this medium was used. maturation ...196213938989
production in mice of tolerance to the toxic manifestations of candida albicans.hasenclever, h. f. (national institutes of health, bethesda, md.) and william o. mitchell. production in mice of tolerance to the toxic manifestations of candida albicans. j. bacteriol. 84:402-409. 1962. - lethal toxic manifestations of candida albicans in mice were demonstrated by the intravenous injection of 10(7) viable yeast cells. untreated control animals had an average survival time of 4.5 to 10 hr after challenge. no multiplication of c. albicans could be demonstrated in the tissues of u ...196213960837
studies on coccidioides immitis. ii. physiological studies on in vitro spherulation.brooks, lula d. (arizona state university, tempe) and william t. northey. studies on coccidioides immitis. ii. physiological studies on in vitro spherulation. j. bacteriol. 85:12-15. 1963.-studies on the amino acids assayed in edamine revealed that the amino acids phenylalanine, tyrosine, and tryptophan, in addition to the amino acid derivatives dihydroxyphenylalanine (dopa), epinephrine, tyramine monohydrochloride (tyramine hcl), and pyrocatechol play an important role in the coccidioides immit ...196314015812
[1st case of wernicke-posadas disease (coccidioides immitis) in salta]. 196214023051
immunogenic properties of nondisrupted and disrupted spherules of coccidioides immitis in mice. 196314034579
disinfection of aerosolized pathogenic fungi on laboratory surfaces. i. tissue phase.the effect of several fungicides on laboratory surfaces contaminated with the tissue phase of aerosolized blastomyces dermatitidis, coccidioides immitis, cryptococcus neoformans, and histoplasma capsulatum was ascertained. a statistical analysis of the data shows the correlation between fungi, surfaces, time, and concentration of disinfectant. all fungicides were effective at established times and concentrations, and the type of contaminated surface affected the fungicidal efficacy. by interpola ...196314063788
acquired immunity to candidiasis in mice.hasenclever, h. f. (national institute of allergy and infectious diseases, bethesda, md.) and william o. mitchell. acquired immunity to candidiasis in mice. j. bacteriol. 86:401-406. 1963.-some protection to chronic candidiasis in mice was produced by sublethal intraperitoneal infection with candida albicans and by the injection in incomplete freund's adjuvant of nonviable coccidioides immitis spherule fragments. other pathogenic or nonpathogenic fungi produced little or no protection. salmonell ...196314066415
studies of the soluble antigens of coccidioides immitis by immunodiffusion. 196314066601
effects of cultural conditions on the development of antigens by coccidioides immitis. 196314075460
experimental viable vaccine against pulmonary coccidioidomycosis in monkeys.converse, john l. (u.s. army biological laboratories, fort detrick, frederick, md.), merida w. castleberry, and ernest m. snyder. experimental viable vaccine against pulmonary coccidioidomycosis in monkeys. j. bacteriol. 86:1041-1051. 1963.-monkeys (macaca mulatta) vaccinated by subcutaneous injection in the forearm with from 10 to 10(8) viable coccidioides immitis arthrospores were protected against respiratory challenge with approximately 7000 viable arthrospores administered 6 months after va ...196314080770
experimental primary cutaneous coccidioidomycosis in the monkey.converse, john l. (u.s. army biological laboratories, fort detrick, frederick, md.), steven p. pakes, ernest m. snyder, and merida w. castleberry. experimental primary cutaneous coccidioidomycosis in the monkey. j. bacteriol. 87:81-85. 1964.-primary cutaneous coccidioidomycosis was studied in the monkey (macaca mulatta) to find a suitable strain of coccidioides immitis for use as a viable vaccine. intradermal inoculation (medial surface of the right forearm) produced more severe vaccination reac ...196414102877
isolation of coccidioides immitis from soil. 196414116583
significance of soil salinity on the ecology of coccidioides immitis.elconin, ann f. (university of southern california, los angeles), roger o. egeberg, and margaret c. egeberg. significance of soil salinity on the ecology of coccidioides immitis. j. bacteriol. 87:500-503. 1964.-an 8-year study of the soil in a small parcel of land where coccidioidomycosis is endemic was conducted. over 5,000 samples collected from the surface of the soil at monthly intervals were tested for the presence of coccidioides immitis. these samples were also analyzed to determine their ...196414127564
disinfection of aerosolized pathogenic fungi on laboratory surfaces. ii. culture phase.the effect of several fungicides on laboratory surfaces contaminated with the culture (spore) phase of aerosolized blastomyces dermatitidis, coccidioides immitis, and histoplasma capsulatum was ascertained. the culture (spore) phase was more resistant to the action of the fungicides than was the tissue (yeast) phase. the addition of a wetting agent increased the efficiency of several fungicides. the time required for disinfection with a given concentration of fungicide, or the concentration requ ...196414131365
production of fluorescent antibody reagents specific for the tissue form of coccidioides immitis. 196414145216
continuous in vitro cultivation of spherules of coccidioides immitis.breslau, abraham m. (veterans administration center and university of california los angeles center for the health sciences, los angeles, calif.), and mike y. kubota. continuous in vitro cultivation of spherules of coccidioides immitis. j. bacteriol. 87:468-472. 1964.-spherules of coccidioides immitis were grown in vitro in continuous culture for more than 4 years. cultures were grown in modified converse medium in a modified lubarsky and plunkett culture tube incubated at 40 c under increased c ...196414151073
fungal multiplication and histopathologic changes in vaccinated mice infected with coccidioides immitis. 196414170420
correlation of histochemistry and fine structure in the development of the "in vitro" spherule of coccidioides immitis. 196314170591
quadriplegia caused by involvement of cervical spine with coccidioides immitis. symptomatic cure after operation and amphotericin-b treatment. 196414171309
the probable geographic distribution of coccidioides immitis in mexico. 196414175564
the treatment of coccidioidal meningitis. the use of amphotericin b in a group of 25 patients.in a study of 25 patients the usefulness of amphotericin b in the control of meningeal infection produced by coccidioides immitis was established. initial treatment must be intensive, consisting of intravenous and intraspinally administered amphotericin b. serologic evaluation of coccidioidal disease provides the most important single criterion for determining the course of the meningeal infection and for estimating the response of the patient to amphotericin b therapy. final control of coccidio ...196414180502
effect of salinity and temperature on coccidioides immitis and three antagonistic soil saprophytes.egeberg, roger o. (university of southern california, los angeles), ann f. elconin, and margaret c. egeberg. effect of salinity and temperature on coccidioides immitis and three antagonistic soil saprophytes. j. bacteriol. 88:473-476. 1964.-experiments exploring the factors which determine the ability of coccidioides immitis to survive and reproduce in the soil in situ are described and discussed. previous work indicated that soil temperatures and salinity influence the growth and distribution o ...196414203366
survival characteristics of mycelia and spherules of coccidioides immitis in a simulated natural environment. 196414225917
immunization of mice to coccidioides immitis: dose, regimen and spherulation stage of killed spherule vaccines. 196514253511
observations on coccidioides immitis found growing naturally in soil. 196514262164
effects of cultural conditions on the development of antigens by coccidioides immitis. ii. complement fixation and immunodiffusion studies with human serum. 196514282466
a rapid method for the isolation of coccidioides immitis from sputum. 196514289283
case report: coccidioides immitis (skin tests and complement fixation tests remain negative despite a tissue diagnosis). 196514333157
[coccidioides immitis infection of the central nervous system; study of a case with necropsy]. 195414357869
analysis of focalized pulmonary granulomas due to coccidioides immitis. 195514375486
role of carbon dioxide in the dimorphism of coccidioides immitis. 196014418103
response of monkeys to respiratory challenge following subcutaneous inoculation with coccidioides immitis. 196014430315
preparation of a fluorescent antibody specific for the yeast phase of histoplasma capsulatum.kaufman, leo (communicable disease center, atlanta, ga.) and william kaplan. preparation of a fluorescent antibody specific for the yeast phase of histoplasma capsulatum. j. bacteriol. 82:729-735. 1961.-rabbit anti-histoplasma capsulatum globulin was conjugated with fluorescein isothiocyanate. this labeled antibody, in addition to staining six strains of h. capsulatum, exhibited strong cross-staining with ten strains of blastomyces dermatitidis and numerous other species of fungi. adsorption of ...196114454457
polysaccharide of coccidioides immitis.pappagianis, d. (university of california, berkeley), e. w. putman, and g. s. kobayashi. polysaccharide of coccidioides immitis. j. bacteriol. 82:714-723. 1961.-soluble polysaccharide from mycelia or culture filtrates of coccidioides immitis was found to consist mainly of mannose, but also included small quantities of galactose and another reducing sugar. isolation of the polysaccharide by ethanol precipitation provided accompanying nitrogenous material. there was 3 to 4% nitrogen, present in am ...196114483753
coccidioides immitis as a potential bioweapon.coccidioides immitis is a fungus endemic to the soil of areas of the southwestern united states, northern mexico, and scattered areas of central and south america. natural infection occurs by inhalation of airborne arthroconidia. c. immitis could be used as a weapon of bioterror or biowarfare with aerosol delivery. its use for this purpose would, however, present a number of obstacles and its effect would be uncertain and most probably limited.200314505283
identification of a protective antigen of coccidioides immitis by expression library immunization.coccidioides immitis is a fungal pathogen of humans and is classified as a select agent. we have identified a new potential vaccine candidate for this pathogen using cdna expression library immunization (eli). a c. immitis spherule-phase cdna library containing 800-1000 genes was divided into 10 pools and each was tested for its protective capacity in balb/c mice against intraperitoneal challenge with 2500 arthroconidia of this dimorphic fungus. the most protective pool, designated pool 7, was f ...200314505918
pathology case of the month. occupational hazard? coccidioidomycosis (coccidioides immitis). 200314506823
transfection of murine dendritic cell line (jaws ii) by a nonviral transfection reagent.dendritic cells are the most potent antigen-presenting cells that initiate and modulate the host immune system. based on their immunostimulatory activity, a variety of strategies have been developed to use dendritic cells as vaccines and immunotherapeutic agents against infection and cancer. genetically modified dendritic cells are useful for immunotherapeutic purposes because of their sustained activity in vivo. however, transfection of dendritic cells with plasmid dna has been very difficult. ...200314513565
coccidioidomycosis osteomyelitis masquerading as a bone tumor. a report of 2 cases.coccidioidomycosis involving the lung is common in endemic areas. however, it is unusual for it to present as a solitary bone lesion.200314526678
donor-related coccidioidomycosis in organ transplant recipients.most cases of coccidioidomycosis in organ transplant recipients arise from either primary infection with coccidioides immitis after environmental exposure or from reactivation of latent infection. herein, we report 2 cases of rapidly fatal, disseminated coccidioidomycosis that occurred in organ transplant recipients who had never lived in or visited an area where c. immitis is endemic. both subjects had received a transplanted organ from the same donor, an individual with unrecognized active coc ...200314557974
cholera vaccine candidate 638: intranasal immunogenicity and expression of a foreign antigen from the pulmonary pathogen coccidioides immitis.vibrio cholerae strain 638 is a live genetically attenuated candidate cholera vaccine in which the ctxphi prophage encoding cholera toxin has been deleted and hapa, encoding an extracellular zn-dependent metalloprotease, was insertionally inactivated. strain 638 was highly immunogenic when inoculated to adult swiss mice by the intranasal route as judged by the induction of a strong serum vibriocidal antibody response. a side-by-side comparison of strain 638 with its isogenic hapa(+) precursor (s ...200314585681
false identification of coccidioides immitis: do molecular methods always get it right?rrna sequence analysis of a partial region of the 18s and 5.8s-internal transcribed spacer 2 (its2) region of chrysosporium keratinophilum highlights its potential molecular misidentification as coccidioides immitis. molecular identification of medically important fungi should not be based solely on sequence analysis of the 18s rrna gene but should be confirmed by sequence analysis of an additional rrna gene locus, such as the its region(s).200314662981
coccidioidomycosis mimicking lung cancer.a 65-year-old female smoker was admitted due to haemoptysis and a pulmonary infiltrate in the right lower lung lobe. tumour was suspected, but there was also a history of 2 years spent in arizona, known to be endemic for the dimorphic fungus coccidioides immitis. igg antibodies and airway culture for c. immitis were negative, and surgery was performed for suspected lung cancer. no malignancy was detected at histopathological investigation, but typical coccidioidal spherulae were observed by silv ...200314732800
in vitro cultivation of the parasitic phase of coccidioides immitis. 195114827917
four new fungicides for coccidioides immitis: 1. sodium caprylate. 2. ethyl vanillate 3. fradicin. 4. thiolutin. 195114847786
a selective medium for the isolation of coccidioides immitis. 195114883868
two new fungicides for coccidioides immitis. 195214904170
coccidioides immitis spherule antigen in a complement fixation test for experimental coccidioidomycosis. 195214920489
the embryonated egg as a culture medium for the animal phase of coccidioides immitis. 195214938615
the cultivation of coccidioides immitis in the embryonated hen's egg. 195214946103
surgical treatment of multiple skull abscesses associated with coccidioidomycosis.this case emphasizes that aggressive neurosurgical management may benefit patients with disseminated coccidioidomycosis and skull abscesses. disseminated infection due to coccidioides immitis, the causative agent of coccidioidomycosis, is difficult to treat and often requires prolonged antifungal therapy in addition to surgical debridement. we present a case of a young woman with disseminated coccidioidomycosis who had multiple skull lesions, two of which penetrated the skull and invaded the sub ...200414998403
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