| the effects of intravenous triton wr-1339 on factor vii coagulant activity and plasma lipoproteins in normocholesterolaemic and hypercholesterolaemic rabbits. | the hypothesis that lipolysis of large lipoproteins by lipoprotein lipase (lpl) has an important influence on the activation of the contact system of coagulation and subsequently on factor vii activation was tested in rabbits rendered hyperlipidaemic by dietary means and/or by injection of triton wr-1339. the dietary treatment involved a control diet and two isocaloric diets containing either a 0.5% cholesterol or 0.5% cholesterol and 7.5% safflower oil supplement. other groups of rabbits were g ... | 1994 | 7841315 |
| nucleotide sequence of a cdna from carthamus tinctorius encoding a glycerol-3-phosphate acyl transferase. | | 1994 | 7846182 |
| fish oil feeding modulates leukotriene production in murine lupus nephritis. | diets enriched with fish oil (fo) ameliorate kidney disease in the mrl-lpr/lpr murine model of lupus nephritis. although the mechanisms of this effect are not known, fo is rich in the polyunsaturated fatty acid eicosapentaenoic acid (epa) which may have profound effects on eicosanoid metabolism. in mrl-lpr/lpr mice, fo feeding reduces renal production of cyclooxygenase metabolites. however, epa may also affect the metabolism of arachidonate by the 5-lipoxygenase (5-lo) pathway and enhanced produ ... | 1994 | 7855311 |
| the effect of dietary lipid manipulation on hepatic mitochondrial phospholipid fatty acid composition and carnitine palmitoyltransferase i activity. | the maximal activity of the overt from of carnitine palmitoyltransferase i (cpt i; ec 2.3.1.21) and its sensitivity to inhibition by malonyl coa were measured in mitochondria prepared from the livers of rats which had been fed for 10 weeks on either a low fat diet (lf; 2.4% fat by weight) or on one of four high fat diets which contained 20% by weight of either hydrogenated coconut oil (hco), olive oil (oo), safflower oil (so) or menhaden (fish) oil (mo). cpt i activity (i.e. activity per g of li ... | 1994 | 7866292 |
| n-3 fatty acids inhibit defects and fatty acid changes caused by phenytoin in early gestation in mice. | our previous work has shown that n-3 fatty acids exert a protective effect against phenytoin-induced cleft palate when phenytoin was administered midgestation [gestational days (gd) 12 and 13] to cd-1 mice. the effects of dietary n-3 fatty acids on phenytoin teratogenicity were investigated at an earlier gestational period (gd 9) to examine whether n-3 fatty acids could exert protective action against other teratogenic effects of phenytoin apart from cleft palate. the effect of phenytoin exposur ... | 1994 | 7869858 |
| differential effects of high-fat diets varying in fatty acid composition on the efficiency of lean and fat tissue deposition during weight recovery after low food intake. | the energetics of body weight recovery after low food intake was examined in the rat during refeeding for 2 weeks with isocaloric amounts of high-fat (hf) diets providing 50% of energy as either lard, coconut oil, olive oil, safflower oil, menhaden fish oil, or a mixture of all these fat types. the results indicate that for both body fat and protein, the efficiency of deposition was dependent on the dietary fat type. the most striking differences were found (1) between diets rich in n-3 and n-6 ... | 1995 | 7869927 |
| the effect of zinc deficiency on erythrocyte membrane lipids of force-fed rats receiving a diet containing coconut oil or fish oil. | in the present study, the effect of zinc deficiency on erythrocyte membrane lipids of force-fed rats that received either a diet with coconut oil and safflower oil (86:14, w/w) or a diet with fish oil and safflower oil (91:9, w/w) was investigated. zinc deficiency caused in the rats fed both types of dietary fat an increase in the amounts of total phospholipids and individual phospholipid classes in erythrocyte membranes. in the rats fed the coconut oil diet, zinc deficiency caused an increase i ... | 1994 | 7881279 |
| effect of dietary fats on cholesterol metabolism and eicosanoid production in hamsters fed undigested fraction of soybean protein. | the undigested fraction of soybean protein (udf) exerts a markedly greater hypocholesterolemic effect than soybean protein itself in rats. the present study was undertaken to confirm the effect in hamsters, a more appropriate animal model for human cholesterol metabolism. hamsters were given diets containing udf at a nitrogen level equivalent to the 20% casein diet. dietary fats, at the 10% level, were perilla oil and safflower oil. there was apparently no increase in the serum and liver cholest ... | 1994 | 7891210 |
| differential response of glucose utilization by three rat muscle tissues to dietary fatty acid composition. | rats were fed a semisynthetic diet containing 14% of either beef fat, safflower oil, or menhaden oil plus 2% corn oil for 7 weeks, and three tissues, diaphragm, heart, and skeletal muscle, were examined for fatty acid composition in their phospholipids and triglycerides. in addition, the lipid concentrations in these tissues were examined. the in vitro oxidation and incorporation of glucose into lipids of these tissues were also examined. skeletal muscle showed the greatest change in phospholipi ... | 1994 | 7891403 |
| colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | epidemiologic and experimental studies suggest that dietary fish oil and vegetable oil high in omega-3 polyunsaturated fatty acids (pufas) suppress the risk of colon cancer. the optimal amount to prevent colon carcinogenesis with perilla oil high in omega-3 pufa alpha-linolenic acid in a 12% medium-fat diet was investigated in female f344 rats. for comparison, safflower oil high in omega-6 pufa linoleic acid was used. | 1994 | 7908858 |
| a high alpha-linolenate diet suppresses antigen-induced immunoglobulin e response and anaphylactic shock in mice. | mice were fed for 2 mo diets having ratios of alpha-linolenate [18:3 (n-3)] to linoleate [18:2(n-6)] of < 0.01, 0.36, 1.0 and 3.9. proportions of safflower seed oil and perilla seed oil were adjusted to obtain these ratios. the dietary alpha-linolenate to linoleate balance was reflected in the proportion of (n-3) and (n-6) highly unsaturated fatty acids with 20- and 22-carbon chains in spleen phospholipids, but the ratio did not affect the proportion of t lymphocyte subsets expressing cd4 and cd ... | 1994 | 7916376 |
| lipid mediated modification of rat heart allograft survival. | the effect on allograft survival of intravenous fat emulsions that differed in the ratio of functionally important n-3 and n-6 fatty acids was studied in a heterotopic cardiac transplant model in rats. twenty percent fat emulsions were administered by continuous infusion at a dosage of 9 g fat/kg body weight per day, starting immediately after transplantation and continuing until complete rejection. the n-6 and n-3 fatty acids represent 75%, 43%, 60%, and 59% of all fatty acids in safflower oil, ... | 1994 | 7916923 |
| effects of continuous tube feeding of dietary fat emulsions on eicosanoid production and on fatty acid composition during an acute septic shock in rats. | the effects of a short-term (5 days) continuous intragastric tube feeding of diets containing n - 6 polyunsaturated fatty acids (pufa) from safflower oil (so) or n - 3 pufa from menhaden oil (mo) on the production of proinflammatory mediators, and on the number of animals surviving after an intravenous injection of lipopolysaccharide (lps) were investigated in rats. the phospholipid fatty acid composition of cell membranes from several organs and of plasma were also analyzed. no marked differenc ... | 1994 | 7918617 |
| in vivo cytogenetic studies on mice exposed to natural food colourings. | safflower yellow and kokum red, two food colourings developed from natural plant products, were assessed in vivo for their clastogenic potential. swiss albino male mice were exposed to the compounds through ip injections. bone marrow cells isolated from femora were analysed for chromosome aberrations. the results show that the two food colourings were weakly clastogenic. | 1994 | 7927081 |
| modulation of exercise-induced immunosuppression by dietary polyunsaturated fatty acids in mice. | the possible interaction between intense exercise, known to suppress the immune response, and nutritive factors, such as polyunsaturated fatty acids (pufa), was examined in inbred female c57bl/6 mice. the animals received for 8 wk either a natural ingredient diet or a diet supplemented with 10 g/100 g linseed oil containing over 50% of 18:3 (n-3) alpha-linoleic acid. other groups received pufa containing only traces of 18:3 (n-3) fatty acid; beef tallow, containing mostly 18:1 (n-9) saturated fa ... | 1994 | 7932851 |
| [contents of free amino acids and water-soluble carbohydrates in safflower plant at different stages of growth]. | as closely related to the development of plant organs, the contents of free amino acids and water-soluble carbohydrates in safflower plant vary with the course of growth. the ratio of the two contents rise with the growing periods, reaching maxima in the later stages of growth. | 1994 | 7945879 |
| influence of dietary fat on the pharmacodynamics of quinidine, procainamide and tocainide in isolated perfused rabbit hearts. | we have reported previously that propafenone decreased ventricular excitability and prolonged ventricular conduction time in hearts from rabbits treated with a lard diet compared to those from rabbits treated with a safflower oil diet. we hypothesized that these effects might be modulated by the lipid solubility of the drug. accordingly, we studied the effects of dietary fat on the pharmacodynamics of the hydrophilic drugs, procainamide and tocainide, and the lipophilic drug, quinidine. weanling ... | 1994 | 7965712 |
| effects of fat feeding on epinephrine secretion in the rat. | adrenal medullary activity increases with fasting, although a role for diet in the regulation of epinephrine (epi) secretion is otherwise unknown. the current studies examined the effects of dietary fat on adrenal medullary function in male cd rats. addition of lard to a lab chow diet (+50% of chow energy) for 4 days lowered epi excretion by 14% (p = 0.0005). two weeks' exposure to diet containing 33% lard (by energy) reduced urinary epi compared with that in animals fed an isoenergetic amount o ... | 1994 | 7977861 |
| dna replication time accounts for tumor growth variation induced by dietary fat in a breast carcinoma model. | female fischer rats were pair-fed on diets containing either safflower oil (so) or fish oil (fo) for 6 weeks. implanted breast 13762 mat tumors had a doubling times of 35.4 and 55.5 h in so and fo rats, respectively (p < 0.001). proliferation kinetics were measured in vivo by bromedeoxyuridine (brdurd) labeling and bivariate dna/brdurd analysis by flow cytometry. after 1 h of pulsing, the labeling index was similar in both groups. however, 6 h later, tumor cells from fo rats had significantly lo ... | 1994 | 7982205 |
| distribution of cholesterol among its carriers in the bile of male and female hamsters. | the distribution of cholesterol among its carriers was studied in the bile of male and female hamsters. sasco hamsters (sasco inc., omaha, ne) were fed a semipurified diet with 0.0% cholesterol and 4% butterfat (group 1, males; group 4, females); a semipurified diet with 0.3% cholesterol and 1.2% palmitic acid (group 2, males; group 5, females); and a semipurified diet with 0.3% cholesterol and 4% safflower oil (group 3, males; group 6, females). at the end of six weeks, gallstones were found on ... | 1994 | 7990658 |
| inhibition of natural killer cell activity by dietary lipids. | natural killer (nk) cells are a subset of cytotoxic lymphocytes found mainly in blood and the spleen. nk cells play a role in natural immunity to microbes, viruses and tumor cells and are involved in the rejection of grafts. the present study investigated the effects of diets containing oils rich in saturated fatty acids, mono-unsaturated fatty acids, n-6-poly-unsaturated fatty acids (pufa) or n-3-pufa on the nk cell activity and on the lymphokine-activated killer (lak) cell activity of rat sple ... | 1994 | 8002045 |
| [a study on the relationship between the growth and yield of safflower under plastic mulching]. | | 1993 | 8003210 |
| in vivo 13c nmr analysis of acyl chain composition and organization of perirenal triacylglycerides in rats fed vegetable and fish oils. | lipid composition of body fat can be a key indicator of nutritional status and a number of human disorders. in vivo 13c nmr provides for repeated, noninvasive analysis of fatty acyl chain composition on individuals, which circumvents classical problems of individual variation and repetitive invasive sampling. it also offers a unique opportunity to examine acyl chain organization in situ. this approach was used to examine the fatty acyl chain composition in the perirenal fat pads of rats fed oliv ... | 1994 | 8006523 |
| effect of dietary fat on glomerular lipid composition and angiotensin ii receptors. | nutritional factors are major etiologic determinants which may affect the incidence or severity of hypertension. since angiotensin ii (ang ii) has a role in some forms of hypertension, the influence of dietary lipid composition on glomerular lipid content and on ang ii receptor parameters was determined. three groups of rats were fed diets containing 14% by weight of 1) beef fat (saturated fatty acid rich), 2) safflower oil (n-6 fatty acid rich), or 3) fish oil (n-3 fatty acid rich), each supple ... | 1993 | 8007446 |
| dietary nitrogen and lipid utilization by growing pigs fed structured triacylglycerides synthesized from medium-chain triacylglycerides and menhaden oil. | a total of 24 crossbred barrows were used in a 19-d metabolism trial to determine the effect of dietary structured triacylglycerides synthesized by the random reesterification of medium-chain triacylglycerides (mct) and menhaden oil on growth performance, nitrogen retention, and apparent digestibilities of nitrogen, lipid, and fatty acids. pigs were randomly assigned to four dietary treatments differing only in lipid source. dietary treatments (percentage by weight of total lipid) contained eith ... | 1994 | 8014160 |
| diets rich in lean beef increase arachidonic acid and long-chain omega 3 polyunsaturated fatty acid levels in plasma phospholipids. | diets rich in meat are claimed to contribute to the high tissue arachidonic acid (20:4 omega 6) content in people in westernized societies, but there are very few direct data to substantiate this assertion. because meat contains a variety of long-chain polyunsaturated fatty acids (pufa) that are susceptible to oxidation, we initially examined the effect of cooking on the long-chain pufa content of beef, and then determined the effect of ingestion of lean beef on the concentration of long-chain p ... | 1994 | 8015364 |
| effect of low and high amounts of a structured lipid containing fish oil on protein metabolism in enterally fed burned rats. | to determine the optimal fat intake and source in nutritional support, we measured the protein-sparing effects of a structured lipid (sl) derived from 60% medium-chain triglyceride (mct) and 40% fish oil and a 50:50 soybean to safflower oil emulsion (long-chain triglyceride, lct). male sprague-dawley rats received an enteral diet for 7 d with either all nonprotein energy as dextrose (control diet) or 10% or 35% nonprotein energy as sl or lct. the rats were burned on day 3. indirect calorimetry a ... | 1994 | 8030599 |
| dietary fish oil enhances macrophage production of nitric oxide. | nitric oxide (no) is recognized as an important mediator of hemodynamic regulation and multisystem organ failure (mof). although polyunsaturated fatty acids (pufa) are known to modify the elaboration of some humoral mediators in mof, their effect upon no production has not been evaluated. this study was designed to examine the effect of omega-3 (omega 3) and omega-6 (omega 6) pufa on macrophage production of no, tnf, pge2, and pgi2. rats were fed diets of 18% by calorie safflower oil (omega 6) o ... | 1994 | 8041151 |
| amount and type of dietary fat regulate pancreatic lipase gene expression in rats. | both amount and type of dietary triglycerides regulate pancreatic lipase, but the mechanism is not fully understood. this study investigated the effects of type (safflower oil and lard) and amount [low (50 g/kg diet) or moderate (174 g/kg diet)] of fat on rat pancreatic lipase (rpl) activity and mrna levels. polyunsaturated safflower oil resulted in 80% greater lipase activity compared with the saturated lard at moderate levels, whereas safflower oil resulted in 50% lower lipase activity compare ... | 1994 | 8064366 |
| n-3 fatty acids reduce in vitro thromboxane production while having little effect on in vitro prostacyclin production in the rat. | male sprague-dawley rats were fed diets with 50% of the energy from fat over a 20-day period. the fats used were hydrogenated beef-fat (hbf), or hbf supplemented with ethyl arachidonate a, safflower oil (so), or a mixture of so and linseed oil (lo). for comparative purposes, another group of animals was fed a diet providing 50% of the energy as butter-fat. in vitro aortic prostacyclin (pgi2) and serum thromboxane (txa2) levels (from clotting blood) were determined by radioimmunoassay of 6-keto p ... | 1994 | 8066095 |
| [the effect of zinc deficiency on heart and brain lipids in rats force-fed with coconut oil or fish oil diets]. | the present study investigated the effect of zinc deficiency on lipid concentrations and fatty acid composition of heart and brain in force-fed rats receiving either a diet with coconut oil and safflower oil (86:14, w/w) or a diet with fish oil and safflower oil (91:9, w/w). four groups of growing male sprague-dawley rats were fed 11.6 g of a semisynthetic diet containing either 0.8 mg zn/kg or 111 mg zn/kg with either coconut oil and safflower oil or fish oil and safflower oil per day by gastri ... | 1994 | 8079508 |
| the effects of dietary oils on the fatty acid composition and osmotic fragility of rat erythrocytes. | the present study was carried out to investigate the effect of different dietary oils representing special fatty acids which varied in chain length, position and number of double bonds on fatty acid composition of erythrocyte membranes and on the osmotic fragility of rat erythrocytes after incubation in nacl solutions of different concentrations. for this purpose all animals were initially fed a control diet (co) containing 10% coconut oil and 0.4% safflower oil for 28 days. after that 10 groups ... | 1994 | 8079509 |
| effect of source and amount of supplemental fat on lactation and digestion in cows. | thirty holstein cows averaging 50 dim were assigned to five dietary treatments for 75 d to determine the effects of source and amount of supplemental fat on milk yield, milk composition, and nutrient digestibilities. diets were 1) control, 2) diet 1 plus 12% whole cotton-seed, 3) diet 2 plus 2.2% safflower oil, 4) diet 2 plus 2.2% prilled tallow fatty acids, and 5) diet 2 plus 4.4% prilled tallow fatty acids. milk yield was increased an average of 2.1 kg/d by addition of 2.2% prilled tallow fatt ... | 1994 | 8083424 |
| effect of eicosapentaenoic acid ethyl ester on albuminuria in streptozotocin-induced diabetic rats. | wistar rats (4-week-old) were administered with streptozotocin (45 mg/kg) through tail veins. after 3 months, diabetic rats were divided into 2 groups. one group (epa group, n = 16) was fed a lipid-free diet (90%, w/w) plus lard (8%) and 90% pure eicosapentaenoic acid ethyl ester (2%) for 6 months. the other group (control group, n = 16) was fed in the same way except that eicosapentaenoic acid ethyl ester was replaced by safflower oil. twenty-four-hour urine was collected just before starting t ... | 1994 | 8089771 |
| effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. | semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high alpha-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. the proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. in the elevated plus maze task, the total number of entries into the open- a ... | 1993 | 8094090 |
| molecular characterization and cloning of an esterase which inactivates the macrolide toxin brefeldin a. | the macrolide antibiotic brefeldin a (bfa) was described as a phytotoxin and pathogenicity factor from alternaria carthami chowdhury, the causal agent of a devastating blight disease in safflower (carthamus tinctorius l.). the toxin is known to inhibit the endoplasmic reticulum-golgi flux and processing. conventional breeding of safflower for resistance to the alternaria blight disease has failed, and in situ detoxification of brefeldin a is a novel approach for the protection of field-grown saf ... | 1994 | 8106385 |
| effects of a small quantity of omega-3 fatty acids on cardiovascular risk factors in niddm. a randomized, prospective, double-blind, controlled study. | to study the effects of a low dose of omega-3 fatty acids on platelet function and other cardiovascular risk factors in patients with non-insulin-dependent diabetes mellitus (niddm). | 1994 | 8112187 |
| psychosocial stress, catecholamines, and essential fatty acid metabolism in rats. | to examine the effects of psychosocial stress and the "stress hormone," epinephrine, on essential fatty acid metabolism in rats, two studies were conducted. in the first, the effects of four weeks of (i) social isolation and (ii) group housing (control) on liver microsomal delta 6 and delta 5 n-6 desaturase activity were studied in group-reared male normotensive (wistar kyoto) and spontaneously hypertensive (shr) rats (n = 5/group). the second study examined the effects of acute ip epinephrine ( ... | 1994 | 8115350 |
| alteration of tumor necrosis factor-alpha production by macrophages from mice fed diets high in eicosapentaenoic and docosahexaenoic fatty acids. | dietary exposure to n-3 fats found in marine fish oils are known to reduce certain inflammatory conditions. although depressed prostaglandin e2 (pge2) production is thought to be a major mechanism of the beneficial effects, the direct effects of n-3 fatty acids on inflammatory macrophage function are not well understood. in this study, production of the inflammatory monokine, tumor necrosis factor-alpha (tnf alpha), by isolated murine macrophages was assessed following a 3-week feeding with diet ... | 1994 | 8118867 |
| effect of dietary n-3 fatty acids upon the phospholipid molecular species of the monkey retina. | to characterize the molecular species composition of ethanolamine glycerophospholipids (egp) in the primate retina and to examine the effects of different dietary fats, the authors fed rhesus monkeys diets containing widely ranging amounts of n-3 fatty acids. | 1994 | 8125741 |
| enhanced blood pressure response to dietary salt in elderly women, especially those with small waist: hip ratio. | to determine the blood pressure responses in elderly normotensive men and women to dietary sodium and to the diunsaturated fatty acid dihomogammalinolenic acid (dgla), which is derived from linoleic acid. | 1993 | 8133020 |
| effects of dietary fatty acid composition on glycerophosphate acyltransferase activity in rat adipose tissue and liver. | 1. how source of dietary fat influences glycerophosphate acyltransferase (gpat) activity in homogenates of adipose tissue and liver was determined using 5 rats per diet that contained 12% fat from either corn- (co), high-oleate-safflower (hoso), palm- or high-stearate-oils. 2. activity was greatest in adipose tissue homogenates of rats fed hoso and co whereas no treatment effects were observed in liver homogenates. 3. no differences in fat pad weights were observed; thus hoso- and co-diets likel ... | 1994 | 8138047 |
| interaction of dietary fatty acids and cyclosporine a in the borderline hypertensive rat: tissue fatty acids. | in this study we examined (i) the effects of cyclosporine a (cs) on tissue lipid composition and (ii) the effect of changes in dietary n-6 fatty acids on tissue responses to cs. fatty acid composition of liver, kidney, heart and brain were determined after 4 wk of treatment with cs (10 mg/kg.d p.o.) in male borderline hypertensive rats (bhr, n = 4/group), whose diet was supplemented with either safflower oil or evening primrose oil (epo). phosphatidylcholine, phosphatidylethanolamine, phosphatid ... | 1994 | 8139392 |
| the effect of dietary fat level and quality on plasma lipoprotein lipids and plasma fatty acids in normocholesterolemic subjects. | this study examined the effect on the plasma lipids and plasma phospholipid and cholesteryl ester fatty acids of changing froma typical western diet to a very low fat (vlf) vegetarian diet containing one egg/day. the effect of the addition of saturated, monounsaturated or polyunsaturated fat (pufa) to the vlf diet was also examined. three groups of 10 subjects (6 women, 4 men) were fed the vlf diet (10% energy as fat) for two weeks, and then in the next two weeks the dietary fat in each group wa ... | 1994 | 8152346 |
| cloning and expression in escherichia coli of a cdna coding for the oleoyl-acyl carrier protein thioesterase from coriander (coriandrum sativum l.). | a cdna for the oleoyl-acyl carrier protein (acp) thioesterase (e.c. 3.1.2.14) from coriander seed endosperm (coriandrum sativum) was isolated using a safflower oleoyl-acp thioesterase cdna probe. the coriander cdna coded for a 42.3 kda protein including a putative 40 amino acid plastid targeting transit peptide. the gene was expressed in escherichia coli and the recombinant protein was isolated to homogeneity by alkyl-acp affinity and anion-exchange chromatography. the pure protein showed a high ... | 1994 | 8155723 |
| effect of dietary fat on cardiovascular risk factors in infancy. | to determine the effects of feeding regimens of varying fat composition on dietary intake and serum lipid and lipoprotein concentrations in older infants. | 1994 | 8165074 |
| reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster. | these experiments systematically evaluated the dual-isotope plasma ratio method for measuring intestinal cholesterol absorption in the hamster. it was found that while the ratio of the 3h- and 14c-labeled cholesterol in the plasma, relative to the respective dose of each that was given, became constant by 72 h after their administration, the percent cholesterol absorption was lower in animals that were fasted before dosing (35.7 +/- 5.5%) than in their fed controls (47.5 +/- 3.7%). furthermore, ... | 1994 | 8169536 |
| liver microsomal mixed-function oxidases in response to polyunsaturated/saturated and n-6/n-3 fatty acid ratios of dietary lipids in rats. | the effects of various polyunsaturated/saturated (p/s; 0.29-2.74) and n-6/n-3 (0.49-11.21) ratios of dietary fatty acids and of phenobarbital (pb) stimulation on the activity of liver microsomal mixed-function oxidase (mfo) system were studied in rats using a combination of palm oil, safflower oil and fish oil concentrate. when the n-6/n-3 ratio was kept constant (4.6-4.9) without induction by pb, the highest p/s ratio (2.74) tended to increase the basal pb-uninduced mfo activities; while the pb ... | 1994 | 8185285 |
| dietary platycladus orientalis seed oil suppresses anti-erythrocyte autoantibodies and prolongs survival of nzb mice. | dietary fish oils rich in 20:5(5,8,11,14,17) and 22:6(4,7,10,13,16,19) are known to replace arachidonic acid [20:4(5,8,11,14)] and to improve the immunopathology of new zealand mice. however, in humans, similar dietary strategies may be impractical because of the high levels of fish oils required. in contrast, we believe that beneficial effects in humans may be attainable using new exotic fatty acids. toward this end, we have focused on 5,11,14-eicosatrienoic acid [5,11,14-eta, 20:3(5,11,14)]. t ... | 1994 | 8200132 |
| linoleic acid enhances mitogen response and survival of septic weanling rats. | immunologic responses to various dietary fats and concentrations remain controversial. the authors examined the effect of dietary omega-3 and omega-6 polyunsaturated fatty acids (pufa) on the immune system of weanling rats. male weanling sprague-dawley rats were fed special liquid diets based on a standard enteral formula: (i) control: 2.2% calories as safflower oil (linoleic acid), (ii) omega-3: 2.2% calories as safflower oil and 30% calories as cod liver oil (linolenic acid), and (iii) omega-6 ... | 1994 | 8201499 |
| effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. | to study the effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma fatty acids and series-2 prostaglandins to determine if the slow conversion of linoleic acid by delta-6-desaturase to gamma-linolenic acid could be bypassed to provide substrate for the formation of dihomo-gamma-linolenic acid, the immediate precursor for series-1 prostaglandins, in control and injured rats. dihomo-gamma-linolenic acid can also compete with arachidonic acid for oxidative metabolism by ... | 1993 | 8222692 |
| effects of purified dietary n-3 ethyl esters on murine t lymphocyte function. | to precisely determine the biologic role of fish oil-derived constituents (n-3 polyunsaturated fatty acids), it is imperative that information on highly purified n-3 polyunsaturated fatty acids be evolved. therefore, we studied the effects of a low dose, short term dietary supplementation with highly purified (n-3) ethyl esters with regard to murine t lymphocyte function. a 10-day dietary supplementation with low dose, highly purified (n-3) fatty acid ethyl esters was examined for effects on mur ... | 1993 | 8228217 |
| purified dietary n-3 polyunsaturated fatty acids alter diacylglycerol mass and molecular species composition in concanavalin a-stimulated murine splenocytes. | a low-dose, short-term dietary supplementation with highly purified (n-3) fatty acid ethyl esters was studied in mice to determine the effect on splenic cell membrane diacylglycerol mass and composition. mice were fed diets containing either 3% safflower oil (saf) ethyl esters, 2% saf plus 1% eicosapentaenoic acid ethyl ester (epa), or 2% saf plus 1% docosahexaenoic acid ethyl ester (dha). following a 10-day feeding period, pathogen-free mice were sacrificed and splenic cells isolated and stimul ... | 1993 | 8257724 |
| dietary fatty acid composition influences energy accretion in rats. | to study the influence of dietary fatty acid composition on energy metabolism, forty male rats were fed elemental diets containing 42% of energy as fish oil, safflower oil, olive oil or beef tallow for 12 wk. food intakes and body weights were measured daily. energy expenditure and body composition were determined using doubly labeled water on the final 2 d. pooled fecal energy losses differed in response to dietary manipulation, with losses greatest in rats fed beef tallow and least in those fe ... | 1993 | 8263604 |
| effects of dietary menhaden oil on mucosal adaptation after small bowel resection in rats. | adaptive hyperplasia of the small intestine is important in the outcome of short bowel syndrome. previous studies have shown that long-chain fats stimulate this process. in the present study, the trophic effects of dietary menhaden oil, a highly unsaturated fat source, on mucosal adaptation following small bowel resection in rats was evaluated. | 1994 | 8276213 |
| modulation by dietary oils and clofibric acid of arachidonic acid content in phosphatidylcholine in liver and kidney of rat: effects on prostaglandin formation in kidney. | the manipulation of 20:4(n - 6) contents in phosphatidylcholine of liver and kidney of rats by dietary oils and p-chlorophenoxyisobutyric acid (clofibric acid) as well as the effects on the formation of prostaglandin e2 in kidney were studied. three groups of rats were fed diets that contained either safflower oil (so) or perilla oil (po) or fish oil (fo) for 1 week. each dietary group was divided into two groups. one group continued the same diet for another 1 week; the second group continued t ... | 1994 | 8280769 |
| two new quinochalcone yellow pigments from carthamus tinctorius and ca2+ antagonistic activity of tinctormine. | two new quinochalcone c-glycosides, hydroxysafflor yellow a (1a) and tinctormine (2a), were isolated from carthamus tinctorius l. (compositae) together with carthamin, safflor yellow b and safflomin c. the structures of 1a and 2a have been determined by spectroscopic methods including heteronuclear multiple-bond multiple-quantum coherence and linked scan fab-ms. the latter compound (2a) was demonstrated to have potent ca2+ antagonistic action. | 1993 | 8281577 |
| influence of dietary vitamin e on the 8-hydroxydeoxyguanosine levels in rat liver dna. | rats were fed either a low vitamin e (ve) diet (-ve), a basal ve diet (+ve, 4.5 mg%), or a high ve diet (+ve, 45 mg%) for 7 weeks. ve content, oxidative dna damage and lipid peroxide levels in their livers were measured. when purified lard was used as a dietary fat, ve content decreased in the low ve group to one-thirtieth of that in the basal ve group; in the high ve group it increased to 4.5-fold that in the basal ve group. corresponding to the ve levels, lipid peroxide levels increased to 2.7 ... | 1993 | 8283310 |
| combined effects of dietary protein and fat on lipid metabolism in rats. | the combined effects of dietary protein (casein, whey protein, or soy protein) and fat (safflower oil, perilla seed oil, or their mixed oil; linoleic acid/alpha-linolenic acid = 5.0) on several lipid parameters were studied in rats. serum cholesterol and triglyceride levels were lower in perilla seed oil groups irrespective of the protein sources. liver triglyceride level, and fecal excretion of steroids were influenced mainly by protein sources, particularly isolated soy protein lowered liver t ... | 1993 | 8283312 |
| differential effects of dietary fats on sympathetic nervous system activity in the rat. | fat feeding stimulates sympathetic nervous system (sns) activity in rats. to determine if fats vary in their potency as stimulants of the sns, [3h]norepinephrine ([3h]ne) turnover was measured in heart and interscapular brown adipose tissue (ibat) of animals fed lab chow diets supplemented with safflower oil, coconut oil, or medium-chain triglycerides (mct). at 5 days, all three fats accelerated [3h]ne turnover in heart and did so equally, but only when the fat supplement represented an increase ... | 1994 | 8289676 |
| dietary deficiency of n-3 fatty acids alters rhodopsin content and function in the rat retina. | to investigate the possibility that previously demonstrated reductions in photoreceptor sensitivity to light in n-3 fatty-acid-deficient rats can be explained by alterations in rhodopsin content and/or function. | 1994 | 8300367 |
| anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models. | anti-inflammatory effects of eicosapentaenoic (epa) and docosahexaenoic acids (dha) were examined on three models of skin inflammation induced in mice by topical application of an arachidonic acid (aa) solution, ultraviolet-b (uvb) irradiation, and contact sensitization with dinitrofluorobenzene. ear oedema reactions induced by aa and uvb irradiation were significantly suppressed in mice fed a daily dose of 300 mg/kg epa for 2 weeks. the contact hypersensitivity reaction was not impaired by epa. ... | 1993 | 8304784 |
| effect of dietary fat and cholesterol on dimethylbenz[a]-anthracene-induced mammary tumorigenesis in sprague-dawley rats. | the effect of dietary fats and cholesterol on dimethylbenz[a]-anthracene-induced mammary tumorigenesis was studied in female sprague-dawley rats. when the dietary fat source (at the 5% level) was palm oil (saturated fat) or corn oil (unsaturated fat), dietary cholesterol at the 0.2% level increased the tumor number of rats fed corn oil, but not those fed palm oil. perilla oil (rich in alpha-linolenic acid) reduced tumor development as compared with safflower oil (rich in linoleic acid), but agai ... | 1993 | 8317898 |
| effects of dietary fatty-acid supplementation on fatty-acid composition and deformability of young and old erythrocytes. | the effects of cell age on erythrocyte phospholipid fatty-acid composition and deformability were examined in 20 healthy adults (11 male, 9 female) prior to and following 12 weeks of dietary supplementation with 3.5 g/day of safflower oil (high in n - 6 fatty acids) or fish oil (high in n - 3 fatty acids). in the absence of dietary supplementation, old erythrocytes demonstrated an increase in filtration time (p < 0.001), an increase in membrane phospholipid total n - 6 fatty acids (p < 0.01), an ... | 1993 | 8323949 |
| [effect of verapamil with renal disease basic-prescription on hemorheology indexes of type ii nephrotic syndrome]. | 24 cases of type ii nephrotic syndrome were studied and divided randomly into two groups. group a: 12 cases treated with verapamil; group b: 12 cases treated with verapamil plus renal disease basic-prescription (rdbp). hemorheology indexes were measured in the two groups before and 4 weeks after the treatment. the results showed hyperviscosity was obviously improved in group a after verapamil administration (p < 0.05), but the improvement in group b was much more significant than that in group a ... | 1993 | 8334344 |
| are dietary saturated, monounsaturated, and polyunsaturated fatty acids deposited to the same extent in adipose tissue of rabbits? | the objective of this study was to determine the effect that different dietary fatty acids would have on the fatty acid composition of adipose tissue. thirty adult rabbits were starved 3-4 wk to deplete adipose tissue stores. they were then refed five different fats (linseed, rapeseed, cocoa butter, palm, and safflower oils) to regain initial body weights. the fatty acids of the adipose tissue, in general, reflected the diet. positive correlations between the amount of the five commonly consumed ... | 1993 | 8338044 |
| dietary fatty acids regulate hepatic low density lipoprotein (ldl) transport by altering ldl receptor protein and mrna levels. | the concentration of ldl in plasma is strongly influenced by the amount and the type of lipid in the diet. recent studies in the hamster have shown that dietary fatty acids differentially affect circulating ldl levels primarily by altering receptor-dependent ldl uptake in the liver. to investigate the mechanistic basis of this effect, rates of receptor-dependent ldl transport in the liver were correlated with ldl receptor protein and mrna levels in hamsters fed safflower oil or coconut oil and v ... | 1993 | 8349814 |
| in vitro hepatic thyroid hormone deiodination in iron-deficient rats: effect of dietary fat. | the effects of different dietary fats on thyroid indices were studied in weanling iron-deficient rats. rats were fed one of five different diets (safflower oil with a casein protein source, safflower oil with defatted beef as the protein source, prime rib, beef tallow with casein and stearate with casein). both dietary fat and iron status (adequate, cn; deficient, id; or iron-deficient replete, id-replete) had significant effects on body weight and hemoglobin concentrations. the tallow-fed anima ... | 1993 | 8350675 |
| n-3 fatty acids from fish oil. effects on plasma lipoproteins and hypertriglyceridemic patients. | in the experimental studies reported in this review, dietary n-3 fatty acids from fish and fish oil had profound hypolipidemic effects in normal subjects and in hypertriglyceridemic patients with combined hyperlipidemia (type ii-b) and types iv and v hyperlipidemia. in these carefully controlled metabolic experiments, dramatic reductions occurred in plasma triglycerides and to a lesser extent in plasma total cholesterol. reductions in vldl, chylomicrons, remnants, ldl, apo b, and apo e were also ... | 1993 | 8352438 |
| dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. | male cd-1 mice were fed diets containing 10 wt% fat composed of a constant amount of n-6 polyunsaturated fatty acids (pufa; safflower oil, 1.5 wt%) and increasing levels of n-3 pufa (up to 1.5 wt%); the remaining fat was a 50:50 mixture of tripalmitin and triolein. four days prior to sacrifice, the animals were injected intraperitoneally with sterile thioglycollate. peritoneal macrophages were analyzed for phospholipid fatty acids, prostaglandin e2 (pge2) synthesis and cytotoxicity towards l929 ... | 1993 | 8373135 |
| influence of feeding unsaturated fats on growth and immune status of mice. | dietary polyunsaturated fatty acids alter the lipid composition and immune systems of mice. to date, most studies have been of short duration and focused on a particular immunologic assay. adult female mice were therefore fed diets rich in 18:1(n-9) (olive oil), 18:2(n-6) (safflower oil), 18:3(n-3) (linseed oil) or 20:5(n-3) and 22:6(n-3) (fish oil-safflower oil, 9:1, wt/wt), for a 5-mo period, encompassing two breeding cycles. offspring from the second breeding cycle were then fed these diets f ... | 1993 | 8381477 |
| effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice. | the purpose of the study was to determine the effect of three different levels of dietary linoleic acid (la) intake on the growth of mda-mb-435 human breast cancer cells in the mammary fat pads of nude mice, and their metastasis to the lungs. these diets were isocaloric, and contained different mixtures of safflower (la-rich) and coconut (saturated fatty acid-rich) oils to provide 23% (w/w) total fat, with 2, 8, and 12% (w/w) la. a fourth group was fed a low-fat, 5% (w/w) corn oil diet. there we ... | 1993 | 8402646 |
| effect of dietary n-3 versus n-6 polyunsaturated fatty acids on hepatic excretion of cholesterol in the hamster. | dietary polyunsaturated fatty acids of the n-6 and the n-3 class show differing effects on serum lipids and hepatic lipoprotein metabolism, which could be induced by alterations in hepatocellular cholesterol balance. as both fatty acid classes exert parallel effects on lipoprotein uptake and synthesis of cholesterol in the liver, we studied whether they have differing effects on the excretory pathways for cholesterol. male syrian hamsters were fed for 3 weeks low-cholesterol diets supplemented ( ... | 1993 | 8409762 |
| white sturgeon tissue fatty acid compositions are affected by dietary lipids. | juvenile white sturgeon (acipenser transmontanus) were fed eight isonitrogenous and isoenergetic purified diets for 9 wk to study their ability to utilize different dietary lipids. each diet contained 15% of control oil mixture (corn oil-cold liver oil-lard, 1:1:1), corn oil, cod liver oil, lard, linseed oil, soybean oil, safflower oil or canola oil. no significant (p > 0.05) differences in percentage of body weight increase, feed efficiency or body composition were observed among sturgeon fed t ... | 1993 | 8410359 |
| modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock. | studies have suggested that the significant suppression of cellular immunity following hemorrhage may be due to an increased release of prostaglandin e2 (pge2) by macrophages. since diets high in n-3 polyunsaturated fatty acids decrease pge2 synthesis, we assessed whether hemorrhage-induced immunosuppression could be prevented by dietary manipulation. c3h/hen mice were fed for 3 weeks with fat sources derived from corn oil, safflower oil, or fish oil, then bled to a mean blood pressure of 35 mm ... | 1993 | 8418775 |
| neuroprotectants in honghua: glucose attenuates retinal ischemic damage. | this study examined the neuroprotective properties of honghua, an extract of safflower used as an herbal medicine in china, in several experimental models of retinal ischemia. | 1993 | 8425843 |
| the effect of fish oil supplements on blood pressure. | we conducted a double-blind, placebo-controlled crossover study to determine the effects of fish oil supplementation on blood pressure in middle-aged men. subjects were randomly assigned to consume either 20 g of fish oil or safflower oil for 12 weeks and then consume the other oil for an additional 12 weeks after a 4-week washout period. we found no significant changes from the pretreatment value in systolic or diastolic blood pressure with the use of fish oil supplements. in addition, there we ... | 1993 | 8427339 |
| transcutaneous application of oil and prevention of essential fatty acid deficiency in preterm infants. | the topical application of vegetable oil was assessed as an alternative means of providing essential fatty acids (efa) to parentally fed preterm infants who were not receiving lipid. three infant pairs ranging in gestational age from 26-32 weeks were studied. safflower oil or safflower oil esters (1 g linoleic acid/kg/day) were applied to available areas daily. all infants rapidly developed biochemical efa deficiency. the plasma fatty acid profiles were similar in infants with or without topical ... | 1993 | 8439192 |
| a comparison of medium-chain and long-chain triglycerides in surgical patients. | available lipid emulsions made from soybean or safflower oil are classified as long-chain triglycerides (lct). in contrast, medium-chain triglyceride (mct) emulsions have different physical properties and are metabolized by other biochemical pathways. to compare the differences between these two fat emulsions, the authors studied 12 surgical patients and 6 volunteers. these subjects were randomly assigned to receive parenteral nutrition with mct or lct emulsion. measurement of arterial and venou ... | 1993 | 8439215 |
| fish oil has protective and therapeutic effects on proteinuria in passive heymann nephritis. | passive heymann nephritis (phn) is a rat model of membranous nephropathy induced by injecting anti-fx1a. the onset of proteinuria in phn is caused by complement-mediated injury to glomerular epithelial cells (gec) accompanied by enhanced glomerular eicosanoid production. in addition, sublethal injury by complement of rat gecs in culture leads to phospholipase activation, phospholipid hydrolysis and release of arachidonic acid and dienoic prostanoids. based on these findings, we undertook to dete ... | 1993 | 8441231 |
| effects of beta-carotene and alpha-tocopherol on rumen bacteria in the utilization of long-chain fatty acids and cellulose. | addition of safflower oil to a growth medium depressed the growth of mixed rumen bacteria above 200 mg/l and did not significantly increase bacteria, even at lower concentrations. however, when 10 mg/l of beta-carotene were added to 50 to 100 mg/l of safflower oil, bacterial growth was significantly increased. when more than 200 mg/l of safflower oil were present, beta-carotene markedly restored the growth capacity. alpha-tocopherol was more effective than beta-carotene, although it inhibited gr ... | 1993 | 8445103 |
| the effect of different dietary fats on gastrin levels in the pyloric antrum and plasma of weaner and adult wistar rats. | the effect of dietary fats on gastrin in the pyloric antrum and plasma of wistar rats was examined. two different age-groups of rats were fed on three different diets in which fat was in the form of menhaden oil (mo), hydrogenated coconut oil (co) and safflower oil (so) respectively. control groups were fed on normal laboratory diet. each diet was isoenergetic and no group showed significant differences in either food intake or weight gain during the experiment. weaner rats fed on the mo diet ex ... | 1993 | 8457523 |
| dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats. | modifications in membrane fatty acid composition and insulin action are possible through dietary intervention. we examined the metabolic fate of (n-3) fatty acids in male wistar rats, using three isocaloric, high fat diets. the et-l, ol-l and saf-l diets contained edible tallow, olive oil and safflower oil, respectively, with identical amounts of (n-3) fatty acids as linseed oil. despite isocaloric feeding, weight gain was lower (p < 0.001) in rats fed the more highly saturated et-l diet (69 +/- ... | 1993 | 8463854 |
| comparative responses of rats to different copper intakes and modes of supplementation. | purified diets deficient in copper and based on either sucrose, egg white, and corn oil or sucrose, casein, corn starch, and safflower oil were fed to young rats. graded amounts of copper were supplied in drinking solutions with the former diet and by addition to the latter diet; anatomical, chemical, and physiologic responses were compared. three micrograms cu/ml and 5 micrograms cu/g were sufficient to maximize the direct assessments of copper nutriture (copper in blood plasma, heart, and live ... | 1993 | 8502663 |
| effect on serum lipids of addition of safflower oil or olive oil to very-low-fat diets rich in lean beef. | the cholesterol-lowering effect of very-low-fat diets rich in lean beef has previously been shown to be reversed with the addition of beef fat. the aim of this study was to determine the effect on serum lipid levels of the addition of safflower oil or olive oil to a very-low-fat diet rich in lean beef. subjects were assigned to either the safflower oil or the olive oil group. in the first week the subjects ate their usual diet; in the second and third weeks all subjects ate a very-low-fat (9% of ... | 1993 | 8509588 |
| the effect of various phospholipids on plasma lipoproteins and liver lipids in hypercholesterolemic rats. | rats were fed a hypercholesterolemic diet (5% lard, 0.5% cholesterol, and 0.25% sodium cholate) containing 5% of dietary phospholipid as safflower phospholipid (sap), soybean phospholipid (sop), or egg yolk phospholipid (egp), or 5% of soybean oil (so) as a control for 4 weeks. the concentrations of plasma cholesterol were significantly higher in rats fed the egp diet than those of the other diets. similarly, the concentrations of chylomicron plus very low density lipoprotein (vldl) cholesterol ... | 1993 | 8509902 |
| effects of randomization of partially hydrogenated corn oil on fatty acid and cholesterol absorption, and tissue lipid levels in rats. | randomization of partially hydrogenated corn oil containing approximately 45% of trans octadecenoic acid only slightly, but not significantly, increased the lymphatic fatty acid absorption in rats. no effect of randomization was observed on cholesterol absorption. when rats were fed these fats at the 8.8% level (with 1.2% safflower oil) for three weeks, the concentrations of serum cholesterol, and serum and liver phospholipid were significantly higher in randomized fat than in control fat, which ... | 1995 | 8538381 |
| prevention of experimental autoimmune encephalomyelitis in lewis rats by a novel fungal source of gamma-linolenic acid. | the effects of oral administration of linoleic- and gamma-linolenic-acid-rich oils on the clinical and histopathological manifestations of experimental autoimmune encephalomyelitis (eae) were investigated in lewis rats 7 d post-inoculation. gamma-linolenic-acid-rich fungal (mucor javanicus) oil at 500 mg/kg body weight abrogated clinical and histological signs of eae although at doses of 200 and 1000 mg/kg body weight it was only effective in delaying the onset of clinical disease. linoleic-acid ... | 1995 | 8541276 |
| alteration of arachidonate levels in tick salivary glands by dietary modification of host blood lipids. | tick saliva contains prostaglandins of the 2-series, believed to facilitate bloodmeal acquisition. because ticks cannot synthesize the prostaglandin precursor, arachidonic acid, investigations were undertaken to study the uptake, incorporation, and distribution of arachidonic acid in the salivary glands of the lone star tick in vitro and in vivo. uptake of [3h]arachidonate by isolated salivary glands was reduced in the presence of low concentrations of arachidonic or eicosapentaenoic acids, but ... | 1996 | 8541571 |
| therapeutic efficacy of n-3 polyunsaturated fatty acid in experimental crohn's disease. | we investigated the therapeutic efficacy of n-3 polyunsaturated fatty acids (pufas) on trinitro-benzene sulfonic acid (tnbs)-induced colitis in the rats, which condition is considered an experimental crohn's disease (cd). in rats with tnbs-induced colitis, feeding with an elemental diet (ed) plus 2% n-3 puea-rich perilla oil significantly suppressed plasma leukotriene (lt) b4 and ulcer index compared to that in rats fed with ed plus 2% n-6 pufa-rich safflower oil (34.2 +/- 12.3 s 63.8 +/- 13.2 p ... | 1995 | 8563904 |
| modulating effect of amount and types of dietary fat on colonic mucosal phospholipase a2, phosphatidylinositol-specific phospholipase c activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male f344 rats. | epidemiological and laboratory animal model studies suggest that the effect of dietary fat in colon carcinogenesis depends not only on the amount but on its fatty acid composition. animal model studies demonstrated that high dietary corn oil or safflower oil rich in omega-6 fatty acids increased the colon tumor promotion, whereas diets containing fish oil high in omega-3 fatty acids had no such enhancing effect. one of the mechanisms by which high dietary fat enhances colon carcinogenesis may be ... | 1996 | 8564967 |
| chemiluminescence detection of mono-, bis-, and tris-hydroperoxy triacylglycerols present in vegetable oils. | a reliable method was needed to analyze molecular species of oxidized vegetable oils. in order to accomplish this goal, mono-, bis-, and tris-hydroperoxides (mono-ooh, bis-ooh, and tris-ooh, respectively) of triacylglycerols formed during autoxidation and photosensitized oxidation of oils were determined by reversed-phase high-performance liquid chromatography in combination with chemiluminescence detection (cl-hplc). mono-ooh was the major species (96% of total hydroperoxides) in trioleoylglyce ... | 1995 | 8569427 |
| protective effect of coconut oil on renal necrosis occurring in rats fed a methyl-deficient diet. | weanling rats fed a methyl-deficient diet develop renal necrosis with acute renal failure. the aim of this experiment was to explore further the role of coconut oil in this experimental model. weanling wistar male rats were fed methyl-deficient and their controls were fed methyl-supplemented diets. coconut oil was fed at 14% and 20%, the latter concentration with and without 1% safflower oil (rich in linoleic acid); other groups received similar diets but instead of coconut oil, a mixture of hyd ... | 1995 | 8570865 |
| the impact of dietary fats, photoperiod, temperature and season on morphological variables, torpor patterns, and brown adipose tissue fatty acid composition of hamsters, phodopus sungorus. | we investigated how dietary fats and oils of different fatty acid composition influence the seasonal change of body mass, fur colour, testes size and torpor in djungarian hamsters, phodopus sungorus, maintained from autumn to winter under different photoperiods and temperature regimes. dietary fatty acids influenced the occurrence of spontaneous torpor (food and water ad libitum) in p. sungorus maintained at 18 degrees c under natural and artificial short photoperiods. torpor was most pronounced ... | 1995 | 8576453 |
| olive oil, other dietary fats, and the risk of breast cancer (italy). | data from a multicenter case-control study on breast cancer conducted in italy have been used to analyze the relationship of olive oil and other dietary fats to breast cancer risk. cases were 2,564 women hospitalized with histologically confirmed, incident breast cancer. controls were 2,588 women admitted to the same network of hospitals for acute, non-neoplastic, non-hormone related, non-digestive tract disorders. cases and controls were interviewed between 1991 and 1994 using a validated food- ... | 1995 | 8580304 |
| the effects of dietary lipid manipulation on the production of murine t cell-derived cytokines. | lymphocytes play an important part in the development and progression of a number of autoimmune and inflammatory disorders, which are characterized by the presence of activated t cells and cytokines at the site of tissue injury and in the circulation. there has been considerable interest in using dietary polyunsaturated fatty acids (pufa), particularly the n-3 pufa found in fish oils, in the therapy of these conditions; such therapies aim, primarily, to suppress t-lymphocyte activity. while seve ... | 1995 | 8580371 |
| effect of fish oil on the development of aom-induced glutathione s-transferase placental form positive hepatocellular foci in male f344 rats. | omega-3 fatty acids, which are contained in fish oils and certain vegetable oils in contrast to corn oil or safflower oil rich in omega-6 fatty acids (linoteic acid), have been reported to reduce the carcinogenesis in several organs. in this study, the modifying effect of menhaden fish oil was investigated on the occurrence of azoxymethane (aom)-induced glutathione s-transferase placental form (gst-p) positive hepatocellular foci, recognized preneoplastic lesions in the liver, in male f344 rats. ... | 1995 | 8584454 |
| effect of n-3 polyunsaturated fatty acid supplemented diet on neutrophil-mediated ileal permeability and neutrophil function in the rat. | fish oil, rich in n-3 polyunsaturated fatty acids, can alter leukotriene production and hence neutrophil function, factors which may be important in the inflammation of crohn's disease (cd). therefore we studied the effect of dietary pufa on neutrophil mediated ileal inflammation and neutrophil function in the rat. | 1995 | 8586775 |
| fish oil ameliorates renal injury and hyperlipidemia in the milan normotensive rat model of focal glomerulosclerosis. | rats of the milan normotensive rat strain (mns) spontaneously develop severe proteinuria and excessive glomerular thromboxane (tx)a2 production at a young age. these abnormalities are accompanied by podocyte alterations, progressive focal glomerulosclerosis (fgs), and interstitial fibrosis, resembling human fgs. since it has been shown that pharmacologic tx-synthase inhibition protects mns rats from these changes, it was hypothesized that a fish oil (fo) enriched diet, by enhancing txa3 producti ... | 1995 | 8589325 |
| effects on reproduction in female offspring from sprague-dawley rats fed 10% snakeweed (gutierrezia microcephala) throughout pregnancy and concurrent treatment with safflower oil. | previous studies determined that safflower oil administration provided protection against the embryotoxicity seen following ingestion of 10% snakeweed (gutierrezia microcephala) throughout pregnancy. sixty-two young primiparous female rats born in those studies were paired with adult male sprague-dawley rats. after 4 d they were removed and carried their litters to term. observations were made of the presence and extent of reproductive effects attributable to the 10% snakeweed exposure and diffe ... | 1995 | 8592831 |