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extraction, isolation and characterization of bioactive compounds from chloroform extract of carica papaya seed and it's in vivo antibacterial potentiality in channa punctatus against klebsiella pkbsg14.the relative efficacy of the isolated pure compound, extracted from carica papaya seed has been tested against live fish, channa punctatus infected with pathogenic strains of klebsiellapkbsg14 (gene bank accession no.kj162158) at a dose of 0.75 cfu/ml in vivo. the isolated compound has been characterized by chromatography and mass spectroscopy studies using ftir, 1hnmr and 13c nmr to identify as well as to determine the nature of the pure compound. this study revealed the extracted biological mo ...201728867632
isolation of ripening-related genes from ethylene/1-mcp treated papaya through rna-seq.since papaya is a typical climacteric fruit, exogenous ethylene (eth) applications can induce premature and quicker ripening, while 1-methylcyclopropene (1-mcp) slows down the ripening processes. differential gene expression in eth or 1-mcp-treated papaya fruits accounts for the ripening processes. to isolate the key ripening-related genes and better understand fruit ripening mechanisms, transcriptomes of eth or 1-mcp-treated, and non-treated (control group, cg) papaya fruits were sequenced usin ...201728859626
use of plant preservative mixture™ for establishing in vitro cultures from field plants: experience with papaya reveals several ppm™ tolerant endophytic bacteria.prevalence of diverse ppm™-tolerant endophytic bacteria in papaya, the broad-spectrum microbicide specified for use in plant tissue cultures, capable of surviving covertly in ms-based medium, with implications in contamination management. plant preservative mixture™ was employed for establishing papaya (carica papaya) tissue cultures from field explants. comparing three recommended practices for controlling endogenous microbial contaminants, axillary shoot tips (1.0-1.5 cm) from cv. arka prabhat ...201728748257
carica papaya ameliorates allergic asthma via down regulation of il-4, il-5, eotaxin, tnf-α, nf-ĸb, and inos levels.natural products have a prime importance as an essential source for new drug discovery. carica papaya leaves (cpl) have been used to treat inflammation in traditional system of medicine.201728732802
extracts of mauritian carica papaya (var. solo) protect sw872 and hepg2 cells against hydrogen peroxide induced oxidative stress.in line with literature documenting the pluripotent activities of tropical fruits, this study evaluated the antioxidant effects of carica papaya fruit extracts at cellular level. investigations using cellular models of oxidative stress provided complementary evidence of the antioxidant activities of papaya fruit. at 2 mg dry weight ml-1, extracts of seed from ripe and unripe fruit significantly reduced oxidative stress levels within human pre-adipocytes (sw872) and hepatocellular carcinoma cells ...201728720948
traditional treatment of human and animal salmonelloses in southern benin: knowledge of farmers and traditherapists.this study aimed to report medicinal plants that are likely to be used in the control of salmonellosis.201728717307
biosynthesis of (s)-naproxen starch ester by carica papaya lipase in intermittent opening reaction mode.inorder to brought s-naproxen into small intestine, an optically pure (s)-naproxen starch ester was produced by lipase through enantio-selective trans-esterification of racemic naproxen methyl ester with pretreatment starch in solvent system. with carefully selection of the reaction medium (isooctane), lipase (carica papaya lipase, cpl) and the reaction mode (intermittent opening), a high conversion rate (48.6%) and enantiomeric excess of product (99.6%) was obtained. the slow release macromolec ...201728655691
sexual dimorphic responses in lymphocytes of healthy individuals after carica papaya consumption.sexual dimorphism in immune response is widely recognized, but few human studies have observed this distinction. food with endo-immunomodulatory potential may reveal novel sex-biased in vivo interactions. immunomodulatory effects of carica papaya were compared between healthy male and female individuals. volunteers were given fixed meals supplemented with papaya for 2 days. changes in blood immune profiles and hormone levels were determined. in females, total natural killer (nk) cell percentages ...201728649252
analysis of map kinase mpk4/mekk1/mkk genes of carica papaya l. comparative to other plant homologues.mitogen-activated protein kinase 4 (mpk4) interacts with the (mitogen-activated protein kinase kinase kinase 1) mekk1/ mitogenactivated protein kinase kinase 1 (mkk1)/ mitogen-activated protein kinase kinase 2 (mkk2) complex to affect its function in plant development or against pathogen attacks. the kegg (kyoto encyclopedia of genes and genomes) network analysis of arabidopsis thaliana revealed close interactions between those four genes in the same plant-pathogen interaction pathway, which war ...201728642634
commercially available glutenases: a potential hazard in coeliac disease.the only treatment for celiac disease (cd) is a gluten-free diet (gfd). however, there is interest among patients in a medical therapy to replace or help with a gfd. therapies include gluten-degrading enzymes (glutenases). there are glutenases available marketed as dietary supplements that have not been demonstrated to digest the toxic epitopes of gluten.201728567117
genome-wide analysis and characterization of aux/iaa family genes related to fruit ripening in papaya (carica papaya l.).auxin/indole-3-acetic acid (aux/iaa) family genes encode short-lived nuclear proteins that mediate the responses of auxin-related genes and are involved in several plant developmental and growth processes. however, how aux/iaa genes function in the fruit development and ripening of papaya (carica papaya l.) is largely unknown.201728476147
occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order brassicales.recently, dibenzylurea-based potent soluble epoxide hydrolase (seh) inhibitors were identified in pentadiplandra brazzeana, a plant in the order brassicales. in an effort to generalize the concept, we hypothesized that plants that produce benzyl glucosinolates and corresponding isothiocyanates also produce these dibenzylurea derivatives. our overall aim here was to examine the occurrence of urea derivatives in brassicales, hoping to find biologically active urea derivatives from plants. first, p ...201728472063
genome-wide transcriptome profiling of carica papaya l. embryogenic callus.genome-wide transcriptome profiling is a powerful tool to study global gene expression patterns in plant development. we report the first transcriptome profile analysis of papaya embryogenic callus to improve our understanding on genes associated with somatic embryogenesis. by using 3' mrna-sequencing, we generated 6,190,687 processed reads and 47.0% were aligned to papaya genome reference, in which 21,170 (75.4%) of 27,082 annotated genes were found to be expressed but only 41% was expressed at ...201728461724
mature leaf concentrate of sri lankan wild type carica papaya linn. modulates nonfunctional and functional immune responses of rats.the leaf concentrate of carica papaya is a traditionally acclaimed immunomodulatory remedy against numerous diseases; nonetheless comprehensive scientific validation of this claim is limited. the present study thus investigated the immunomodulatory potential of carica papaya mature leaf concentrate (mlcc) of the sri lankan wild type cultivar using nonfunctional and functional immunological assays.201728446195
trace metals in vegetables and fruits cultivated around the surroundings of tummalapalle uranium mining site, andhra pradesh, india.vegetables (tomato - solanum lycopersicum, green chilli - capsicum annum and bitter gourd - momordica charantia) and fruits (banana - musa acuminata colla, papaya - carica papaya and mosambi - citrus limetta) from the cultivated areas around the tummalapalle uranium mining site were analyzed for trace metals (al, cr, mn, fe, ni, cu, zn, pb, be, v, co, cd and u) using inductively coupled plasma-mass spectrometer (icp-ms). as per the estimated data, the concentrations of trace metals in vegetables ...201428962264
hepatotoxicity of the methanol extract of carica papaya. (paw-paw) seeds in wistar rats.activity of carica papaya. linn. (commonly known as paw-paw.) seed extract in liver physiology of albino (wistar) rats was studied. the meoh extract of c. papaya. seeds were soxhlet extracted. tolerated doses of c. papaya. were estimated in acute toxicity studies and administered orally, single or repeated doses, for 30 days to adult male rats weighing between 190 and 200 g, which were divided into four groups of five rats per group. group 1 received 10 mg/kg; group 2 received 50 mg/kg; group 3 ...200528925838
papaw-carica papaya, l.: from new commercial plants and drugs. 188228998867
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