| chemical constituents of gentianaceae xxiv: anti-mycobacterium tuberculosis activity of naturally occurring xanthones and synthetic analogs. | anti-mycobacterium tuberculosis h37 rv data are presented for the individual xanthones of canscora decussata schult and swertia purpurascens wall (gentianaceae); a few, from the former species, showed significant activity. additionally, sturcture--activity relationships of these compounds are evaluated on the basis of the minimum inhibitory concentration data of 18 naturally occurring xanthones bearing 1,3,5- 1,3,5,6-, 1,3,6,7-, 1,3,5,8-, 1,3,5,6,7-, and 1,3.6,7,8-oxygenated patterns and six syn ... | 1978 | 565403 |
| tuberculosis of the male urethra. | tuberculosis of the male urethra is a rare lesion, with only 21 cases reported in the literature. two patients with tuberculosis of the urethra, who presented with multiple periurethral fistulas and a periurethral abscess, are described. in both patients there was associated genitourinary tuberculosis. mycobacterium tuberculosis could be isolated from the urine and the exudate of the perineal ulcers. biopsy from the perineal ulcers demonstrated tuberculous granulation tissue with tuberculous bac ... | 1979 | 572879 |
| studies on some new thiosemicarbazones as potential antitubercular agents. | twenty-one 4-aryl-3-thiosemicarbazides and their new vanillin-4-aryl-3-thiosemicarbazones have been prepared in good yield. antitubercular activity of five of the vanillin-4-aryl-3-thiosemicarbazones was evaluated against mycobacterium tuberculosis strain h37 ra in löwenstein-jensen medium. in addition to ir, biological activity and tlc studies for thiosemicarbazones were carried out. | 1979 | 582729 |
| induction and expression of immunity after bcg immunization. | the induction and expression of immunity to mycobacterium tuberculosis after bcg immunization by intravenous, subcutaneous, and pulmonary routes has been investigated in mice. the speed with which protective immunity was engendered was a function of inoculum size; the immunization route was a less influential factor. tuberculin hypersensitivity varied both with the inoculim size and immunization route, being least after pulmonary immunization. once immunity was established, a steady state ensued ... | 1977 | 591061 |
| a comparative study of tuberculous and other mycobacterial infections and their associations with malignancy. | we reviewed 162 cases of bacteriologically proved mycobacterial disease. nontuberculous acid-fast bacilli were responsible for 27 per cent of the infections, a higher frequency than has previously been reported, and mycobacterium kansasii and mycobacterium avium-intracellulare were isolated with equal frequency. this indicates that mycobacterium avium-intracellulare may be a significant agent of disease in the midwest as well as the southeast. there are no useful clinical, radiographic, or labor ... | 1978 | 619723 |
| primary inoculation tuberculosis of the skin. prosector's paronychia,. | subsequent to an autopsy of a tuberculotic cadaver, a pathology resident presented with a painless paronychia and axillary adenopathy after surgical incision and broad-spectrum antibiotics had failed to improve his condition. demonstration by culture of mycobacterium tuberculosis var hominis, positive smears, and findings of acid-fast organisms in a skin biopsy specimen proved the diagnosis of tuberculosis. conversion of a previously negative skin test permitted the diagnosis of primary inoculat ... | 1978 | 646369 |
| antitubercular 2,8-bis(alkylaminomethyl)phenazines. | the preparation and antitubercular properties of a series of 2,8-bis(alkylaminomethyl)phenazines are described. these compounds all inhibited the growth of mycobacterium smegmatis atcc 607 in vitro. 2,8-bis(dibutylaminomethyl)phenazine (5c) was also active against a lethal mycobacterium tuberculosis h37rv infection in mice. | 1978 | 650670 |
| mycobacterial lymphadenitis in childhood. | a total of 42 cases of childhood mycobacterial adenitis have been studied to define the optimal steps that lead to the correct diagnosis of this disease. antigens from the atypical mycobacteria are not currently available, so the usefulness of tuberculin skin testing as a diagnostic tool was examined. skin testing differentiates mycobacterial adenitis from infection caused by pyogenic bacteria. in addition, repetitive skin testing with tuberculin over a three- to six-month period is also useful ... | 1978 | 665593 |
| [tuberculosis of the peripheral lymph nodes]. | in germans as well as in "foreign workers" acute tuberculous lymphnode disease is most often seen in the drainage areas of old sometimes even calcified tuberculous processes. the infective agent is almost always mycobacterium tuberculosis. resistant strains are rarely found even in recurrent disease. differential diagnosis includes tulareaemia, cat scratch syndrome, lues, and foreign body reaction. in those cases in which the histopathologic findings are similar to productive tuberculosis, sarco ... | 1978 | 669538 |
| the isolation of an atypical mycobacterium from three wood pigeons with tuberculosis-like lesions. | cultural and biological tests were carried out on the livers and spleens of three wood pigeons. acid-fast organisms were observed in histological sections and smears taken from tuberculosis-like lesions in the organs. biological tests revealed that all the isolates sensitised the guinea pig to avian tuberculin. one was pathogenic for chickens while the remaining two were non-pathogenic. all were non-pathogenic for rabbits and domestic pigeons. the organisms could not be cultured on conventional ... | 1978 | 674851 |
| ppd-tuberculin and ppd-battey dual skin testing of hospital employees and medical students. | tuberculin ppd and ppd-battey skin tests were simultaneously applied to 3,882 employees of charity hospital and 408 medical students at louisiana state university. the ppd was doubtful (5 to 9 mm induration) in 253 of the total 4,290 persons tested (5.9%). in 86 of these 253 persons, the reaction to pdd-battey was greater than the reaction to ppd, presumably identifying a subpopulation with a falsely positive ppd and therefore at considerably lower risk of developing future tuberculous disease. ... | 1978 | 684472 |
| [immunologic reactivity of breast cancer patients]. | an attempt was made to further characterize some conditions determining the decrease of immunological responsiveness in patients with mammary gland cancer. to reveal the delayed-type cell hypersensitivity, the antigens of mycobacterium tuberculosis, staphylococcus, fungi candida were employed as well as a contact allergen--dinitrochlorobenzene. tests were made prior to the treatment and in different terms after it. to determine t-lymphocytes the rosette-formation test with sheep erythrocytes was ... | 1978 | 695430 |
| possible use of frequency-pulse-modulated electron capture gas-liquid chromatography to identify septic and aseptic causes of pleural effusions. | frequency-pulse-modulated electron capture gas-liquid chromatography was used in conjunction with appropriate derivatization procedures to obtain chromatograms from extracts of pleural effusions. these chromatograms were used to rapidly classify the various types of pleural effusions. with this method we have been able to distinguish among a limited number of effusions caused by congestive heart failure, mycobacterium tuberculosis, and some other types of bacterial empyemas and pleural effusions ... | 1978 | 701463 |
| inhibition of mycobacterium intracellulare by some vitamin k and coenzyme q analogues. | because vitamin k is present in several species of mycobacteria, and because coenzyme q has been found to stimulate the growth of mycobacterium tuberculosis and atypical mycobacteria, 8 quinones that can be considered to be dual analogues of vitamin k and coenzyme q were tested for their activity against mycobacterium intracellulare. one compound, 6-cyclo-octylamino-5,8-quinolinequinone (cqq) exhibited considerable activity in vitro against several strains of mycobacterium intracellulare at a co ... | 1978 | 707875 |
| granulomatous hepatitis and pleuritis after ileal bypass for obesity. | a patient is presented who developed a granulomatous hepatitis and pleuritis approximately 7 months after an ileal bypass procedure for morbid obesity. although the etiological agent was presumed to be mycobacterium tuberculosis no pathogenic organism was grown from the liver, pleura, bone marrow, sputum, or gastric aspirate. the possibly increased susceptibility of these patients to mycobacterial infections is discussed. the value of obtaining serum levels of ethambutol, isoniazid, and rifampin ... | 1978 | 717272 |
| synthesis and quantitative structure--activity relationships of some antibacterial 3-formylrifamycin sv n-(4-substituted phenyl)piperazinoacethydrazones. | a series of 14 3-formylrifamycin sv n-(4-substituted phenyl)piperazinoacethydrazones has been synthesized and evaluated for their antimicrobial activity. the compounds were found active against bacillus subtilis, staphylococcus aureus, mycobacterium phlei, and mycobacterium tuberculosis but not as active as rifampin. the compounds also exhibited significant activity against clostridium perfringens and in this bacterial system some were more active than rifampin. the qsar showed that the activity ... | 1978 | 722738 |
| tuberculous peritonitis in manitoba. | between jan. 1, 1971 and june 30, 1976 the authors diagnosed tuberculous peritonitis in 17 patients. the basis for the diagnosis was a positive culture for mycobacterium tuberculosis from the peritoneal fluid or nodules (nine patients) or the presence of caseating granulomas in biopsy specimens of the peritoneum (eight patients). fifteen of the 17 patients were women. eleven were north american indians and eight of them suffered from alcoholism. the predominant symptoms of abdominal pain, progre ... | 1978 | 737593 |
| [mycobacterium tuberculosis and i--some memories]. | | 1975 | 768586 |
| variations between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis. | isoniazid is the most effective and widely used antituberculosis drug. the metabolism of isoniazid is noninducible and the primary metabolic route determining the rate at which isoniazid is eliminated from the body is acetylation. there are large diffrences between individuals in the rates at which isoniazid and certain other hydrazides and some sulfonamides are acetylated. the acetylation of isoniazid is inherited in a simple mendelian fashion, individuals being either slow, heterozygous rapid, ... | 1976 | 773583 |
| oxidative phosphorylation in mycobacterium tuberculosis bcg. | | 1976 | 783037 |
| regional immunotherapy with intrapleural bcg for lung cancer. | a living vaccine, the bacille calmette guérin (bcg) strain of mycobacterium tuberculosis bovis, has been administered in a single postoperative intrapleural dose as a controlled equivalent of postoperative empyema in 38 patients following pulmonary resection for lung cancer. this form of regional immunotherapy is reasonably well tolerated if the vaccine is given in a limited dose and if a follow-up course of isoniazid (inh) is administered. in this report, the technical details of this new thera ... | 1976 | 785107 |
| interaction of rifampin and glucocorticoids. adverse effect on renal allograft function. | three renal transplant patients experienced progressive loss of renal allograft function during rifampin treatment for mycobacterium tuberculosis. previous studies have shown that rifampin causes induction of enzymes in hepatic microsomes that increase the catabolism of glucocorticoids. evidence is presented that in our patients, the loss of renal allograft function during rifampin therapy was the result of decreased glucocorticoid effect presumably related to increased catabolism of the glucoco ... | 1976 | 787563 |
| sources of energy production in mycobacterium tuberculosis bcg. | | 1976 | 802119 |
| laboratory practices in mycobacteriology: results of a survey of oklahoma laboratories. | | 1975 | 803237 |
| treatment of atypical mycobacterial cervical adenitis with rifampin. | the clinical response of atypical mycobacterial cervical adenitis to standard antituberculous therapy has been disappointing. surgical procedures in the anterior cervical triangle are difficult and often complete excision is impossible. in each of four children with atypical mycobacterial cervical adenitis in this study, the institution of rifampin therapy was followed by complete resolution. previously rifampin, a well-tolerated, orally administered drug, had been used effectively with mycobact ... | 1975 | 803310 |
| [evaluation of the results obtained in mycobacterium laboratory during from 1968 to 1972 (author's transl)]. | | 1975 | 803312 |
| relation between delayed hypersensitivity and immunity in tuberculosis. | | 1975 | 803355 |
| letter: names for tubercle bacilli. the status of bcg. | | 1975 | 803358 |
| structural study of the poly-l-glutamic acid of the cell wall of mycobacterium tuberculosis var hominis, strain brevannes. | | 1975 | 803372 |
| the role of nontuberculous mycobacterial skin test antigens in the diagnosis of mycobacterial infections. | a retrospective study of 212 patients with mycobacterial infection was conducted to determine intradermal reactivity to five tuberculin units (tu) of purified protein derivative of mycobacterium tuberculosis (ppd-s), and purified protein derivatives (ppds) derived from non-tuberculous mycobacteria. ppds b, y, a, g, and f were used. the study included 138 patients with mycobacterium tuberculosis infection, and 74 with proved nontuberculous mycobacterial infection. eight possible patterns of skin ... | 1975 | 803434 |
| [the relationship between the structure and antimicrobial activity of several substituted omega-nitrosterols]. | | 1975 | 803457 |
| the adjuvant activity of mycobacterial rna preparations and synthetic polynucleotides for induction of delayed hypersensitivity to purified protein derivative in guinea pigs. | the adjuvant activity of mycobacterial rna and synthetic polynucleotides for the induction of delayed hypersensitivity to ppd was determined. it was shown that when mycobacterial rna or synthetic polynucleotides are injected together with purified protein derivative (ppd), delayed hypersensitivity to ppd developed as compared to no detectable delayed response when ppd was administered alone without adjuvant into guinea pigs. four different criteria were employed to detect delayed hypersensitivit ... | 1975 | 803534 |
| immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity. | the effects of acute vs. chronic glucocorticosteroid administration on established cellular immune responses were studied in guinea pigs previously sensitized to tuberculin. a greater than 50% reduction in circulating lymphocytes was observed 4 hr after injection of soluble hydrocortisone and 24 hr after daily subcutaneous injections of depot cortisone acetate. after a single dose of hydrocortisone, peripheral lymphocyte migration inhibitory factor (mif) production and antigen and mitogen-induce ... | 1975 | 803535 |
| primary demyelination as a nonspecific consequence of a cell-mediated immune reaction. | primary demyelination occurs in a variety of human and experimental diseases known to be associated with the presence of inflammatory cells. however, the mechanism of demyelination remains unclear. the possibility that myelin can be damaged as a nonspecific consequence of a specific delayed type of hypersensitivity reaction directed at nonnervous tissue antigens was investigated. guinea pigs were sensitized to tuberculin with freund's complete adjuvant, and were challenged in the central and per ... | 1975 | 803545 |
| genital tuberculosis: cytologic detection. | | 1975 | 803746 |
| biologically active components from mycobacterial cell walls. iv. protection of mice against aerosol infection with virulent mycobacterium tuberculosis. | | 1975 | 803876 |
| biologically active components from mycobacterial cell walls. v. granuloma formation in mouse lungs and guinea pig skin. | | 1975 | 803877 |
| [synthesis and antibacterial activity of n-(benzothiazolyl-2-carbonyl)-n-1-(2-thiazolyl)hydrazine]. | the synthesis and chemical behaviour of n-(benzothiazolyl-2-carbonyl)-n-1-(2-thiazolyl)hydrazines is described. all the products were screened in vitro for antimicrobial activity. some of them were found to give positive results. | 1975 | 803904 |
| sensitization potentials and immunologic specificities of neomycins. | the use of sensitization indices for expressing allergenic skin reactions in guinea pigs is described. the method is convenient for comparing allergens and cross-reacting substances and permits the use of both irritating and nonirritating challenge concentrations of allergens. it also permits determination of both optimal reading time and challenge concentrations for each experiment. by this technique commercial neomycin complex, neamine (neomycin a), neomycin b, neomycin c, and streptomycin wer ... | 1975 | 804015 |
| [the etiological mystery of sarcoidosis]. | | 1975 | 804178 |
| [findings from immunomorphologic studies of cerebrospinal fluid lymphocytes in several infectious-allergic diseases of the nervous system]. | | 1975 | 804218 |
| editorial: delayed hypersensitivity and immunity in tuberculosis. | | 1975 | 804285 |
| phage types of mycobacterium tuberculosis in cultures isolated from eskimo patients. | the phage type of each of 3 colonies selected at random from cultures of mycobacterium tuberculosis isolated from 233 eskimo patients was determined. in 33 cultures, colonies of different phage types were observed. in 22 cases, the differences in phage types paralleled differences in drug susceptibility of the bacteria. a comparative study with cultures of mycobacterium tuberculosis isolated from while patients did not reveal differences in phage types among 3 colonies from the same culture. thi ... | 1975 | 804287 |
| role of antibodies to galactocerebroside in experimental allergic encephalomyelitis. | the possible role of antibodies to galactocerebroside was investigated in as rats with experimental allergic encephalomyelitis (eae) induced by guinea-pig spinal cord. passive immunization with rat or rabbit antiserum to galactocerebroside did not protect rats from eae. active immunization with galactocerebroside before the encephalitogenic challenge produced antibody to galactocerebroside but also failed to protect rats from eae. these experiments did not support previous suggestions that antib ... | 1975 | 804435 |
| biologically active components from mycobacterial cell walls. iii. production of experimental allergic encephalomyelitis in guinea-pigs. | the efficacy of various fractions of mycobacterial cell walls in producing experimental ahlergic encephalomyelitis (eae) has been evaluated. bcg (bacillus-calmette-buérin) cell walls were effective in producing eae in all animals at dose levels as low as 40 mug. study of subfractions of these cell walls revealed the following: (1) wax d was active, but required larger doses than bcg cell walls; (2) the chloroform-methanol-soluble (cms) portion of wax d and p3 (a mycolic acid-trehalose ester cont ... | 1975 | 804436 |
| immunological sequelae of trichinella spiralis infection in mice: effect of viability and route of bcg administration on nematode-induced immunopotentiation. | mice were infected with 200 trichinella spiralis 22 days preceding administration of 4 times 10-6 viable or heat-killed bcg. the effect of the route of bcg administration on the subsequent delayed hypersensitivity response to old tuberculin was investigated by injecting the bacteria either intravenously, intraperitoneally, or subcutaneously. animals of the various groups were tested for delayed hypersensitivity footpad responses 28 days after bcg inoculation. infection with t. spiralis was found ... | 1975 | 804446 |
| purification and properties of tuberculin-active protein from mycobacterium tuberculosis. | when mycobacterium tuberculosis was grown on sauton medium, intracellular tuberculin-active protein was produced. this product was purified by chromatography on deae-cellulose and sephadex g-200 and was obtained in crystalline form. the crystals were plates, somewhat irregular in shape, about 50 mum in length and 25 mum in width. the yield corresponded to a 1.5% over-all recovery of total protein. ultracentrifugal analysis showed only one major component with a calculated molecular weight of 970 ... | 1975 | 804476 |
| amino acid sequence of tuberculin-active protein from mycobacterium tuberculosis. | the complete amino acid sequence of tuberculin-active protein from tubercle bacilli was determined. the sequences of residues of tryptic, chymotryptic, and peptic peptides were established by edman degradation and dansylation (5-dimethylaminonaphthalene-1-sulfonyl) and by digestion with carboxypeptidases a and b. certain peptides were further degraded using partial acid hydrolysis. the aspartyl and glutamyl residues at positions 70 and 73 are present as amides. there is one intrachain disulfide ... | 1975 | 804477 |
| the induction of delayed hypersensitivity in guinea pigs to poly u and poly a:u. | guinea pigs were sensitized to poly u and poly a:u so that subsequent stimulation of spleen cells from these immunized animals with poly u and poly a:u resulted in the production of migration inhibitory factor (mif). mif was also produced when spleen cells from animals immunized with poly a:u were cultured in the presence of mycobacterial rna or whole viable h37 ra cells. negative dermal reactions were observed when guinea pigs immunized with poly a, poly a:u were skin tested wtih these same syn ... | 1975 | 804517 |
| structure-activity correlations among rifamycin b amides and hydrazides. | structure-antibacterial activity correlation equations have been developed for aseries of 44 amides and 25 hydrazides of rifamycin b in five bacterial systems. the best amide equations show that activity is a parabolic function of log p. a wide variation in log po was found for the various bacterial systems. the most important correlation parameter in the hydrazide equations is omicron*. the significance of this finding is somewhat obscured by the high degree of collinearity among the parameters ... | 1975 | 804555 |
| [characteristics of the protein spectra of individual representatives of mycobacteria]. | a study of proteinograms of some strains of mycobacteria with the use of the method of electrophoresis in polyacrylamide gel showed that individual strains had characteristic protein spectra which could serve as one of the possible taxonomic characteristics. analysis of proteinograms of three groups of mycobacteria (tuberculosis, atypical and saprophytes) by electrophoretic mobility of the fractions, with consideration to their homologous character and by the intensity of protein fractions in th ... | 1975 | 804775 |
| [comparison of the protein spectra of typical and atypical mycobacteria using the disc electrophoresis method in polyacrylamide gel]. | protein spectra of 19 strains of typical and atypical mycobacteria were studied. the advantage of protein extracts obtained from the living cells destroyed by press was shown in experiments of fractionation in polyacrylamide gel. on the basis of similarity indices of the protein spectra a conditioned scheme reflecting the extent of similarity of the cultures under study was drawn. there were revealed protein fractions common for the majority of the cultures studied; it was impossible to isolate ... | 1975 | 804788 |
| world health organization studies on bacteriophage typing of mycobacteria. subdivision of the species mycobacterium tuberculosis. | the ability of lytic mycobacteriophages to subdivide the species mycobacterium tuberculosis reliably has been studied using a series of 100 strains isolated from cases of tuberculosis in the netherlands. techniques for the propagation and application of the viruses have been standardized, as have the conditions for growth and preparation of bacterial strains. on the basis of lytic results with 11 mycobacteriophages, it is proposed that the species mycobacterium tuverculosis may be subdivided int ... | 1975 | 804840 |
| influence of tubercle aggregate size on severity of adjuvant arthritis in the rat. | incorporation into freund's complete adjuvant of tuberculous aggregates smaller than 90 mum in size is essential to produce adjuvant arthritis in the rat, and this correlates with a significantly greater degree of cell-mediated immunity to tuberculous antigens produced by small aggregates (smaller than 90 mum), when compared with large (larger than 90 mum) aggregates. this requirement for small aggregates to render freund's complete adjuvant arthritogenic is not paralleled by detectable differen ... | 1975 | 804868 |
| preservation of mycobacterial suspensions at -55 degrees c. | suspensions in dilute sauton's medium of 14 mycobacterial strains grown under identical conditions were prepared with bacilli harvested at their midlog phase of growth,and were frozen and stored at -55 degrees c. survivals, estimated by cfu determinations after periodic intervals of storage, showed no adverse effect of freezing and thawing on any of the strains. effectiveness of preservation, however, varied from strain to strain and no correlation existed between effectiveness and species of my ... | 1975 | 804986 |
| protein synthesis in stimulated lymphocytes. ii. amino acid requirements. | | 1975 | 805000 |
| biological studies of amiclenomycin. | the action of amiclenomycin (am) in inhibiting growth of microorganisms is specific against mycobacteria in vitro, but the antibiotic does not show a therapeutic effect against tubercle bacilli in vivo. the action of am is reversed by biotin, desthiobiotin (dtb) and 7,8-diaminopelargonic acid (dapa), but not by 7-keto-8-aminopelargonic acid (kapa), pimelic acid and glutaric acid. in the presence of am, cultures of mycobacterium smegmatis and bacillus sphaericus accumulated kapa, whereas the form ... | 1975 | 805118 |
| evaluation of the animal assay of tuberculin intended for use in humans. ii. usefulness. | | 1975 | 805143 |
| functional studies of peyer's patches: evidence for their participation in intestinal immune responses. | the pattern of responsiveness of lymphocytes from peyer's patches, spleen, mesenteric, and inguinal nodes of guinea pigs was compared after oral and parenteral immunization. after oral immunization with bcg, peyer's patch lymphocytes showed the best in vitro proliferative responses to ppd (tuberculin). responsiveness to clostridia, normal constituents of the intestinal microflora, also was significant in peyer's patches, and low or absent in the other lymphoid tissues examined. in animals immuni ... | 1975 | 805177 |
| fatal undiagnosed tuberculosis in hospitalized patients. | thirty-seven cases of active tuberculosis were misdiagnosed in chaim sheba medical center in the years 1964-1974. the diagnosis was made only after death. twenty-one patients were over 60 years of age. eleven had hematological disorders, and 12 received steroids (sometimes with immunosuppressive or cytotoxic drugs). misdiagnosis of miliary tuberculosis is a growing problem and demands special attention. the postmortem examination must be systematic and must include bacteriological and histologic ... | 1975 | 805189 |
| isolation of clostridium in human infections: evaluation of 114 cases. | one hundred fifty-two strains of clostridium were isolated from 144 patients over a 14-month-peroid. these included 23 recognized species and 23 strains that were unclassified. soft tissues or abscesses yielded 84 strains of clostridium. intraabdominal sites predominated, but clostridia were recovered from empyema, carcinoma, frostbite with gas gangrene, muscle abscess, aortic graft, and brain abscess. blood cultures yielded 65 strains of clostridium from 49 patients, representing 0.3% of 16,314 ... | 1975 | 805193 |
| antigenic evaluation of mycobacterium lepraemurium. | immunodiffusion analysis of mycobacterium lepraemurium indicated the presence of at lease six antigens. comparative analysis of the m. lepraemurium antigen-antibody system with similar systems established for other mycobacterial species, showed that m. lepraemurium shared up to two antigens with other species. although our observations are in accord with some of the studies on the antigenic mosaic of m. lepraemurium, they are in disagreement with the observations of stanford (1973) concerning a ... | 1975 | 805240 |
| [a study on prevalence of resistance to major drugs among newly admitted pulmonary tuberculosis patents in 1972. part 1. comparison of result in 1972 with those in 1957, '59, '61, '63, '66 and '69]. | | 1975 | 805311 |
| [proceedings: tuberculosis--50 years of clinical study: its past and present. (2) chemotherapy]. | | 1975 | 805312 |
| [proceedings: mycobacterium tuberculosis]. | | 1975 | 805313 |
| [proceedings: compounds of mycobacterium tuberculosis]. | | 1975 | 805314 |
| [proceedings: immunology of mycobacterium and its infection]. | | 1975 | 805315 |
| [proceedings: chemotherapy in tuberculosis. (1) antibacterial function of drugs]. | | 1975 | 805316 |
| the early history of vitamin k. | | 1975 | 805522 |
| the incidence of urine cultures positive for mycobacterium tuberculosis in a general tuberculosis patient population. | when urine specimens from a general tuberculosis patient population of 328 were submitted routinely for mycobacterial cultures, 33 patients (10 per cent) a positive turine cultures for mycobacterium tuberculosis. in 22 patients (7 per cent) a positive urine culture for m. tuberculosis was unanticipated. review of these 22 patients revealed that all had denied current genitourinary symptoms, 58 per cent had urinalyses within normal limits, and 58 per cent had normal intravenous pyelograms. thus, ... | 1975 | 805556 |
| antiarthritic and antithrombotic effects of topically applied dimethyl sulfoxide. | | 1975 | 805559 |
| letter: malaria vaccines. | | 1975 | 805627 |
| [pneumonia as a cause of death in children (author's transl)]. | the yearly death-rate from pneumonia in children aged one month to 15 years has fallen in schleswig-holstein from 1.8 (1954-1958) to 0.6 per ten thousand (1969-1973). at the same time, total death-rate in the same age group has fallen from 14.5 to 9.3 per ten thousand children. the proportion of pneumonia in the total death-rate was 5.3% in 1971-1973, 1.6% in the first month of life and, after the sixteenth year, 2.3%. pneumonia was in fourth place (after accident, malformation and neoplasm) as ... | 1975 | 805694 |
| effect of t-cell depletion on the growth of bcg in the mouse footpad. | the growth of mycobacterium bovis (bcg montreal) and m. tuberculosis erdman was determined in normal and t-cell depleted (thxb) mice when injected subcutaneously into a hind footpad. the bacilli multiplied only to a limited extent within the footpad itself but the infection quickly spread to the draining popliteal lymph node to eventually reach the liver, spleen and lung. the amount of systemic growth seen in the thxb mice was 10-100 times greater than in the normal controls, all of which develo ... | 1975 | 805768 |
| antitubercular activity of substituted 5-oxo-1-thiocarbamoyl-3-pyrazoline-4-alkanoic acid derivatives. | several novel pyrazolin-5-ones prepared by the cyclization of variously substituted thiosemicarbazone derivatives of ethyl formylsuccinate, ethyl acetylsuccinate, and ethyl acetylglutarate were tested for antitubercular activity against mycobacterium tuberculosis, human type, strain h37rv, by a tube dilution technique. minimum inhibitory concentrations (mic) for these derivatives ranged from 0.05 to 100 mug/ml. the most active compound was ethyl 3-methyl-1-methylthiocarbamoyl-5-oxo-3-pyrazoline- ... | 1975 | 805834 |
| [organization of bacteriological examination of tuberculosis patients in the lithuania ssr]. | | 1975 | 806074 |
| [clinico-microbiological comparisons in renal tuberculosis after nephrectomy]. | | 1975 | 806075 |
| [rifampicin in the treatment of patients with chronic destructive tuberculosis complicated by drug intolerance and mycobacterium drug resistance]. | | 1975 | 806177 |
| lesions and tuberculin sensitivity in calves inoculated with group iii mycobacterial isolates from swine, pen soil, and cattle feed. | fifteen calves, 7 to 11 months of age, were inoculated intradermally with group iii mycobacteria ---6 isolates from swine, 1 isolate from cattle feed, and 2 isolates from soil of swine farrowing pens. calves were tuberculin tested at 50 days and killed approximately 60 days after inoculation. only 1 of the cultures, that of porcine origin (93c-0), produced any lesions. there were a caseo-calcareous granuloma 3mm in diameter in the regional lymph node (left prescapular) and a granuloma at the ski ... | 1975 | 806238 |
| comparison of lymphocyte stimulation and tuberculin skin reactivity in mycobacterium bovis-infected macaca mulatta. | lymphocyte immunostimulation tests were conducted on mycobacterium bovis-infected and tuberculin-negative rhesus macaques (macaca mulatta), using purified protein derivative (ppd) tuberculins prepared from strains of mycobacterium tuberculosis and mycobacterium avium. the stimulation of lymphocytes with m tuberculosis ppd was significantly greater for the m bovis-infected macaques than for the noninfected controls (p smaller than 0.05). the response of lymphocytes from m bovis-infected macaques ... | 1975 | 806239 |
| the antigenicity in guinea pigs and monkeys of three mycobacterial polysaccharides purified by affinity chromatography with concanavalin a. | the antigenicity of 3 polysaccharides purified from culture filtrates of mycobacterim tuberculosis by affinity chromatography using a concanavalin a-agarose absorbent was studied. all 3 purified polysaccharides were found to be potent elicitors of delayed skin test reactions in sensitized guinea pigs and in a tuberculos monkey. this antigenicity could not be attributed to contaminating protein. small dermal reactions were also observed in control guinea pigs. all 3 polysaccharides reacted with p ... | 1975 | 806241 |
| effect of isoniazid on the protoplasmic viscosity in mycobacterium tuberculosis. | the effect of isoniazid on the protoplasmic viscosity in the h37ra strain of mycobacterium tuberculosis was determined by using electron spin resonance spectroscopy and a small spin label tempone (2,2,6,6-tetramethylpiperidone-n-oxyl radical). isoniazid (0.5 mug/ml) caused the internal cellular viscosity to increase gradually over the first 15 h of exposure from a rotational correlation time value (t(c)) of 2.4 x 10(-10) to 3.4 x 10(10) s and then decrease linearly to the control level after 27 ... | 1975 | 806256 |
| functional activation of immune lymphocytes by antigenic stimulation in cell mediated immunity. i. requirement for macrophages in antigen-induced mif production by guinea pig immune lymphocytes in vitro. | | 1975 | 806355 |
| [significance of homogenizing factors and of media in the isolation od inh-resistant tubercle bacilli]. | | 1975 | 806488 |
| [detection of tubercle bacilli in diagnostic samples from tuberculous patients as a function of the method of homogenization and the type of medium]. | | 1975 | 806489 |
| the adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of mycobacterium tuberculosis strain dt. | a water-soluble mycobacterial glycopeptide was obtained in large quantities from the culture supernatant fluid of m. tuberculosis strain dt. this glycopeptide was strongly adjuvant-active when injected, in a water-in-oil emulsion contianing ovalbumin, into guinea-pigs. in addition, it was devoid of cord factor toxicity in mice, polyarthritogenic activity in rats and cavity stimulating activity in rabbit lungs. | 1975 | 806515 |
| transfer of adoptive immunity to tuberculosis in mice. | a system is described for studying adoptive immunity to tuberculosis in syngeneic mice. donor mice were immunized with 10(4) bcg intravenously, and lymphoid cells were harvested 28 days later. adoptive immunity was measured in recipient mice in terms of the inhibition of growth of bcg in the liver and spleen following intravenous injection. adoptive immunity was expressed optimally when recipients were sublethally irradiated (500 r), challenged with 10(4) to 10(5) viable organisms, and given sen ... | 1975 | 806520 |
| site of inhibitory action of isoniazid in the synthesis of mycolic acids in mycobacterium tuberculosis. | the cellular mycolate synthetase activity of mycobacterium tuberculosis h37ra was previously shown to be very sensitive to isoniazid (wang, l., and k. takayama. 1972. antimicrob. agents chemother. 2: 438-441). we have now examined the question of how isoniazid inhibits the synthesis of mycolic acids. the saponifiable 14-c-labeled lipids of control and isoniazid-treated cells (1.0 mug/ml, 60 min) were compared on a sephadex lh-20 column, and it appeared that the synthesis of the intermediate-size ... | 1975 | 806645 |
| induction of t-lymphocyte responses to a small molecular weight antigen. ii. specific tolerance induced in azebenzenearsonate (aba)-specific t cells in guniea pigs by administration of low doses of an aba conjugate of chloroacetyl tyrosine in incomplete freund's adjuvant. | the experiments presented in this paper demonstrate that the induction of tolerance on the one hand and the induction of delayed sensitivity on the other hand can be accomplished by administration of similar doses of azobenzene-arsonate conjugated to n-chloracetyl tyrosine (aba-t) to guinea pigs with the determining factor being the absence or presence, respectively, of activating bacterial products in the adjuvant mixture used. thus, complete, persistent aba-t-specific t-cell tolerance can be i ... | 1975 | 806648 |
| proceedings: bacteriophage typing of strains of mycobacterium tuberculosis isolated in south-east england. | | 1975 | 806685 |
| [determination of the activity of the process in pulmonary tuberculoma]. | | 1975 | 806910 |
| [effect of cycloserine and terizidon on intracellular reproduction of mycobacterium tuberculosis]. | | 1975 | 806911 |
| [action in vitro of associations of tuberculostatic drugs on strains of mycobacteria with multiple drug resistance]. | | 1975 | 806949 |
| [tuberculosis]. | | 1975 | 806988 |
| [detection of mycobacterium tuberculosis]. | | 1975 | 806989 |
| [anonymous acid-fast bacilli]. | | 1975 | 806990 |
| the use of in-vitro and in-vivo experiments with mycobacterium tuberculosis in helping to plan chemotherapy regimens. | | 1975 | 806991 |
| tuberculosis of the cervical lymph nodes : a clinical, pathological and bacteriological study. | biopsies taken from the lymph nodes of 59 consecutive patients with cervical lymph node tuberculosis were examined bacteriologically and histologically. the series consisted of 18 men (mean age 40 years) and 41 women (mean age 46 years). mycobacteria were isolated from 41 specimens (69 per cent), m. tuberculosis from 40 patients and a mycobacterium of the m. avium-m. intracellulare complex from one. all the m. tuberculosis strains were sensitive to streptomycin, isoniazid and pas. no mycobacteri ... | 1975 | 807003 |
| cord factor revisited: a tribute to the late dr. hubert bloch. | | 1975 | 807004 |
| the effect of metal ions on the atypical mycobacteria: growth and colony coloration. | the effect of 30 metal ions on growth and colony color has been evaluated for 215 isolates of "atypical" mycobacteria and 5 isolates of mycobacterium tuberculosis. of the total number of ions tested, ten proved to have a variable effect on growth and eight induced specific changes in colony coloration. although both effects could be generally related to the runyon grouping system, neither procedure proved to be practical or specific for differential identification of individual species. spectrop ... | 1975 | 807055 |