| lipomannan and lipoarabinomannan from a clinical isolate of mycobacterium kansasii: novel structural features and apoptosis-inducing properties. | although mycobacterium kansasii has emerged as an important pathogen frequently encountered in immunocompromised patients, little is known about the mechanisms of m. kansasii pathogenicity. lipoarabinomannan (lam), a major mycobacterial cell wall lipoglycan, is an important virulence factor for many mycobacteria, as it modulates the host immune response. therefore, the detailed structures of the of m. kansasii lam (kanlam), as well as of its biosynthetic precursor lipomannan (kanlm), were determ ... | 2003 | 12829695 |
| activity of clarithromycin alone and in combination in a murine model of mycobacterium kansasii infection. | activities of clarithromycin alone and in combination with rifampicin, gatifloxacin or linezolid were evaluated against mycobacterium kansasii in a murine infection model. clarithromycin was the most active single agent. rifampicin and gatifloxacin had similar activities, but were less active than clarithromycin. clarithromycin in combination with rifampicin was the most active combination therapy. | 2003 | 12837729 |
| protracted mycobacterium kansasii carpal tunnel syndrome and tenosynovitis. | | 2003 | 12841025 |
| usefulness of a new mycobacteriophage-based technique for rapid diagnosis of pulmonary tuberculosis. | a new mycobacteriophage-based technique (phagetek mb) was compared with standard culture and staining techniques for diagnosis of pulmonary tuberculosis. a total of 2,048 respiratory specimens from 1,466 patients collected from february 2000 to march 2001 were studied by both (i) conventional methods (direct microscopic examination [auramine-rhodamine fluorochrome], and culture in bact/alert 3d and solid media) and (ii) the phagetek mb assay. this phenotypic test utilizes specific mycobacterioph ... | 2003 | 12843014 |
| antiadhesive peptides as the inhibitors of mycobacterium kansasii phagocytosis. | initial entry of mycobacteria into the cells depends upon the formation of a molecular complex between antigen 85 (ag85), located on the bacterial cell wall, and serum protein-fibronectin (fn) [nat. struct. biol. 7 (2000) 141; nat. struct. biol. 7 (2000) 94]. therefore, a way of preventing a mycobacteria invasion could be to inhibit the interaction between fibronectin and leucocyte cellular receptors of the integrin type. we found that some antiadhesive peptides (such as rgdvy and grgd), derived ... | 2003 | 12860208 |
| mycobacterium kansasii empyema in a renal transplant recipient case report and review of the literature. | | 2003 | 12865827 |
| mycobacterium kansasii disease among patients infected with human immunodeficiency virus type 1: improved prognosis in the era of highly active antiretroviral therapy. | to investigate changes in survival and trends in occurrence of mycobacterium kansasii disease in hiv-infected patients after implementation of highly active antiretroviral therapy (haart). | 2003 | 12870689 |
| [pulmonary mycobacterioses--frequency of occurrence, clinical spectrum and predisposing factors]. | various types of non-tuberculous mycobacteria can be the aetiologic factors of chronic lung infections especially in patients with underlying chronic lung diseases. the aim of this study is to present the cases of pulmonary mycobacterioses observed in institute of tuberculosis and lung diseases in the years 1995-2001. there were 23 patients, 12 men and 11 women in the age between 35-77 years, mean 56 years. 16 out of 23 patients had underlying respiratory problems, mainly healed tuberculosis (7) ... | 2002 | 12884564 |
| mycobacteriosis in two captive florida manatees (trichechus manatus latirostris). | two male florida manatees (trichechus manatus latirostris) died at the marine aquarium in inagi city, tokyo, japan. acid-fast bacteria were demonstrated in tuberculoid nodules in the lungs from both manatees. mycobacterium marinum and m. fortuitum were isolated from one manatee; m. marinum and m. kansasii were cultured from the second animal. this report confirms the pathogenicity and potentially fatal outcome of mycobacterial infection in manatees. in addition, the pathologic response to infect ... | 2003 | 12885137 |
| lipomannans, but not lipoarabinomannans, purified from mycobacterium chelonae and mycobacterium kansasii induce tnf-alpha and il-8 secretion by a cd14-toll-like receptor 2-dependent mechanism. | lipoarabinomannans (lams) are glycolipids from the mycobacterial cell wall that exhibit various biological activities, including proinflammatory and anti-inflammatory responses. however, little is known about the properties of lipomannans (lms), considered to be precursors of lams. in this study, we provide evidence that lms purified from mycobacterium chelonae and a clinical strain of mycobacterium kansasii stimulated mrna expression and secretion of tnf-alpha and il-8 from human macrophage-lik ... | 2003 | 12902506 |
| evaluation of a modified single-enzyme amplified-fragment length polymorphism technique for fingerprinting and differentiating of mycobacterium kansasii type i isolates. | the usefulness of single-enzyme amplified-fragment length polymorphism (aflp) analysis for the subtyping of mycobacterium kansasii type i isolates was evaluated. this simplified technique classified 253 type i strains into 12 distinct clusters. the discriminating power of this technique was high, and the technique easily distinguished between the epidemiologically unrelated control strains and our clinical isolates. overall, the technique was relatively rapid and technically simple, yet it gave ... | 2003 | 12904399 |
| epidemiological, clinical, and prognostic differences between the diseases caused by mycobacterium kansasii and mycobacterium tuberculosis in patients infected with human immunodeficiency virus: a multicenter study. | a multicenter, comparative study was performed to determine the epidemiological, clinical, and prognostic differences between the diseases caused by mycobacterium tuberculosis and mycobacterium kansasii in human immunodeficiency virus (hiv)-infected patients. from 1 january 1995 through 31 december 1999, 25 hiv-infected patients received diagnoses of m. kansasii infection, and another 75 were selected as control subjects from among patients who had m. tuberculosis infection. variables associated ... | 2003 | 12905144 |
| cardiac tamponade in patients with human immunodeficiency virus disease. | the characteristics of cardiac tamponade in patients with human immunodeficiency virus (hiv) disease were examined by evaluating the cases, case series, and related articles, including autopsy series, identified through a comprehensive literature search. one-hundred eighty-five cases of cardiac tamponade have been reported in patients with hiv disease. sex data were available in 176 patients, of whom 154 (87%) were males. the mean age was 34.7 +/- 10.4 years (range, 11 months to 61 years). mean ... | 2003 | 12934767 |
| early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis. | to evaluate the response rate to antimycobacterial drug therapy in patients with cystic fibrosis (cf) suffering from infection by non-tuberculous mycobacteria (ntm). | 2003 | 12948065 |
| antimycobacterial and antifungal isosters of salicylamides. | a set of 40 derivatives of 3-hydroxypicolinic acid and 2-sulfanylbenzoic acid, isosteric to salicylanilides was synthesized. the compounds were evaluated for in vitro activity against mycobacterium tuberculosis, mycobacterium kansasii and mycobacterium avium, candida albicans, candida tropicalis, candida krusei, candida glabrata, trichosporon beigelii, aspergillus fumigatus, absidia corymbifera, trichophyton mentagrophytes and microsporum gypseum. structure-activity relationships of antimycobact ... | 2003 | 12953220 |
| the antibiotic sensitivity of mycobacterium kansasii. | | 1956 | 13425425 |
| comparative intradermal reactions of tuberculosis patients to purified tuberculin (ppd) and purified sensitin prepared from mycobacterium kansasii. | | 1961 | 13765309 |
| biological and chemical studies on mycobacteria. relationship of colony morphology to mycoside content for mycobacterium kansasil and mycobacterium fortuitum. | fregnan, g. b. (university of wisconsin, madison), d. w. smith, and h. m. randall. biological and chemical studies on mycobacteria. relationship of colony morphology to mycoside content for mycobacterium kansasii and mycobacterium fortuitum. j. bacteriol. 82:517-527. 1961.-using a suitable technique and an adequate medium it was possible to show a unique and uniform type of colony characteristic for mycobacterium kansasii (photochromogen) and for mycobacterium fortuitum strains freshly isolated ... | 1961 | 13894938 |
| two varieties of mycobacterium kansasii with different clinical significance. | | 1962 | 13999291 |
| [apropos of mycobacterium kansasii]. | | 1962 | 14036092 |
| mycobacterium kansasii as infecting agent in a case of pulmonary disease--a case report. | | 1963 | 14080838 |
| genetic relationships between mycobacterium kansasii and mycobacterium tuberculosis. | | 1964 | 14183997 |
| [pathogenic action of mycobacterium kansasii for the mouse]. | | 1964 | 14186947 |
| relationship of mycoside content and colony morphology for group 2 and group 3 unclassified mycobacteria. | navalkar r. g. (university of wisconsin, madison), e. h. wiegeshaus, and d. w. smith. relationship of mycoside content and colony morphology for group ii and group iii unclassfied mycobacteria. j. bacteriol. 88:255-259. 1964.-the relationship between colony morphology and mycoside content previously reported for mycobacterium kansasii and m. fortuitum does not extend to group ii and group iii unclassified mycobacteria. mycoside distribution studies permit a division of group ii cultures into thr ... | 1964 | 14198897 |
| the role of air in the photochromogenic behavior of mycobacterium kansasii. | | 1964 | 14213850 |
| cell walls of three strains of mycobacteria (mycobacterium phlei, mycobacterium fortuitum and mycobacterium kansasii). preparation, analysis and digestion by lysozymes of different origins. | | 1964 | 14236706 |
| the effect of isoniazid and para-aminosalicylic acid on infection in mice produced by mycobacterium kansasii. | | 1965 | 14259997 |
| comparative study of the mode of action of paraminosalicylic acid on mycobacterium kansasii and mycobacterium tuberculosis. | | 1965 | 14280945 |
| thrice-weekly clarithromycin-containing regimen for treatment of mycobacterium kansasii lung disease: results of a preliminary study. | we initiated a prospective trial of an intermittent clarithromycin-containing regimen for the treatment of patients with mycobacterium kansasii lung disease. eighteen patients (10 men and 8 women) with m. kansasii lung disease received a regimen consisting of 500-1000 mg of clarithromycin, 25 mg/kg ethambutol, and 600 mg of rifampin 3 times per week. the primary treatment end point was a 12-month period during which sputum cultures were sterile while the patient was receiving therapy. four male ... | 2003 | 14557961 |
| 3-benzyl-2h-1,3-benzoxazine-2,4(3h)-diones, a new group of antimycobacterial compounds against potentially pathogenic strains. | a series of derivatives of 3-benzyl-2h-benzoxazine-2,4(3h)-dione substituted in positions 6, 7 or 8 on the benzoxazine, and in positions 3 or 4 on the benzyl moiety was synthesized. the compounds were evaluated for in vitro antimycobacterial activity against mycobacterium avium and two strains of mycobacterium kansasii. the disadvantage of the compounds is in their low solubility in water. the antimycobacterial activity of n-benzylsalicylamides correlates with that of 3-benzyl-2h-1,3-benzoxazin- ... | 2003 | 14572865 |
| [pulmonary mycobacterium kansasii infection in okayama, japan]. | our group discovered the first patient with pulmonary m. kansasii infection in okayama prefecture in 1976. the first case and another ten more patients over about eight years came exclusively from the southern seaside area of kurashiki city (mizushima marine industrial district and its vicinity). thereafter, the cases of pulmonary m. kansasii infection have spread geographically and chronologically from the mizushima district to neighboring areas in the prefecture. we considered the possibility ... | 2003 | 14577346 |
| disseminated mycobacterium kansasii infection with pulmonary alveolar proteinosis in a patient with chronic myelogenous leukemia. | a 64-year-old woman with chronic myelogenous leukemia (cml) was admitted due to prolonged fever and lung infiltrates. an open lung biopsy was required to make the diagnosis of pulmonary alveolar proteinosis (pap) and infection with mycobacterium kansasii. she was treated successfully with combined antimycobacterial therapy for 14 months. however, the leukemia progressed and the patient developed recurrent bilateral lung infiltrates. blood and bronchoalveolar fluid cultures yielded growth of acin ... | 2003 | 14587059 |
| analogs of rgdvy and grgd peptides inhibit mycobacterium kansasii phagocytosis. | continuing our research on mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the rgdvy and grgd sequences. it was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. distinct inhibitory activity was found in the case of thymopentin (rkdvy), the active fragment of thymopoietin. in this case the mycobacterium phagocytosis inhibition should be combined ... | 2003 | 14612180 |
| [a new group of potential antitubercular agents: antimycobacterial n-benzylsalicylamides]. | linking up with a previous study of antimycobacterial compounds, several groups of n-benzylsalicylamides were prepared and their antimycobacterial activities against the strains mycobacterium tuberculosis, mycobacterium kansasii, and mycobacterium avium were evaluated. the obtained data were analyzed by free-wilson method in comparison with their isosteric analogues of 3-hydroxypicolinic and 2-sulfanylbenzoic acids described in the previous communication. | 2003 | 14661368 |
| mycobacterium kansasii, species or complex? biomolecular and epidemiological insights. | mycobacterium kansasii is one of the best known nontuberculous mycobacteria and large awareness exists about its involvement in diseases both of immunocompetent and immunocompromised patients. two phenotypic variants within this species, which differ for the virulence in guinea pig too, have been detected since 1962. it was however following recent progress in genetic studies that a large variability emerged. major contributions to the disclosure of such findings came from the dna probes hybridi ... | 2003 | 14672048 |
| molecular analysis of mycobacterium kansasii isolates from the united states. | we studied the population genetics of mycobacterium kansasii isolates from the united states by pcr restriction enzyme analysis (pra) of the 441-bp telenti fragment of the hsp-65 gene and pulsed-field gel electrophoresis (pfge) of genomic dna with the restriction endonucleases asei, drai, and xbai, and we compared the patterns to those previously reported from france and japan. by pra, 78 of 81 clinical isolates (96%) from the united states belonged to subspecies i. with pfge, 28 asei patterns, ... | 2004 | 14715741 |
| atypical mycobacterium breast infection. | | 2004 | 14717764 |
| septal perforation secondary to mycobacterium kansasii infection. | we report the first recorded case of a septal perforation caused by mycobacterium kansasii. this atypical mycobacterium is finding increasing prevalence with the increasing incidence and longevity of human immunodeficiency (hiv) infections. cases of chest infection, sinusitis, septic arthritis, osteomyelitis, pericarditis, brain abscess, cutaneous and oral lesions have all now been reported. this discovery represents a rare but important differential in the aetiology of septal perforation. | 2003 | 14738615 |
| characterization of the susceptibility of mycobacteria in bactec 12b media containing panta that had been supplemented with ceftazidime, and characterization of the individual components of panta in the presence of c18-carboxypropylbetaine. | c(18)-carboxypropylbetaine (cb-18) specimen processing has enhanced the diagnosis of mycobacterioses by smear, culture, and nucleic acid amplification. however, toxic side effects of cb-18 in liquid culture, especially in the presence of antibiotics, have been reported. the interaction of cb-18 at 20-25 microg/ml with the individual components of the antibiotic supplement panta that had been fortified with ceftazidime (panta-caz) was characterized in bactec 12b cultures using four mycobacterial ... | 2004 | 14744453 |
| antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids. | a series of 17 hydrochlorides of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids with the alkoxy group in position 2, 3 or 4 on the phenyl ring, and basic substituents attached to the moiety in position 3, were evaluated for in vitro antimycobacterial activity against the strains of mycobacterium tuberculosis, m. kansasii and m. avium. to describe the structure-antimycobacterial activity relationships (qsar), an approach based on the free-wilson method was employed to express ... | 2003 | 14976713 |
| structural analysis of biological aliphatic compounds using surface-enhanced fourier transform raman spectroscopy. | the surface-enhanced raman scattering (sers) technique for fourier transform raman spectrometry is employed to reveal the chemical structure of biological aliphatic compounds consisting of folded, long aliphatic chains. the structural analysis is performed via the measurements of the accordion-vibration modes generated in the ordered, long aliphatic chain. the sers spectra after subtraction of a background spectrum give segment lengths that are almost perfectly consistent with the chemical struc ... | 2004 | 14991663 |
| toll-like receptor 2 (tlr2)-dependent-positive and tlr2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. | lipoarabinomannans (lam) and lipomannans (lm) are integral parts of the mycobacterial cell wall recognized by cells involved in the innate immune response and have been found to modulate the cytokine response. typically, mannosylated lam from pathogenic mycobacteria have been reported to be anti-inflammatory, whereas phosphoinositol-substituted lam from nonpathogenic species are proinflammatory molecules. in this study, we show that lm from several mycobacterial species, including mycobacterium ... | 2004 | 15034058 |
| discontinuation of secondary prophylaxis in aids patients with disseminated non-tuberculous mycobacteria infection. | from june 1994 to june 2002, disseminated infections due to non-tuberculous mycobacteria (ntm) were diagnosed in 42 of 716 (5.9%) non-haemophiliac hiv-infected patients aged > or =15 years who were treated at national taiwan university hospital. the median age of these patients was 35 years (range, 27 to 60 years). the median cd4+ cell count and plasma viral load at the time of diagnosis of disseminated ntm infections were 8 x 10(6)/l (range, 0 to 892 x 10(6)/l) and 37,600 copies/ml (range, <400 ... | 2004 | 15060688 |
| synthesis and antimycobacterial activity of 1,2,4-triazole 3-benzylsulfanyl derivatives. | series of 3-benzylsulfanyl derivatives of 1,2,4-triazole and 4-methyl-1,2,4-triazole were synthesized by alkylation of starting triazole-3-thiol with appropriately substituted benzyl halide. all members of the set were evaluated for in vitro antimycobacterial activity against mycobacterium tuberculosis, m. avium, and two strains of m. kansasii. the activities were expressed as the minimum inhibitory concentration. the compounds exhibited only a moderate or slight antimycobacterial activity. mini ... | 2004 | 15081345 |
| bacillary angiomatosis with cytomegaloviral and mycobacterial infections of the palpebral conjunctiva in a patient with aids. | we report the clinical and histopathologic findings of bacillary angiomatosis involving the palpebral conjunctiva with concomitant infection by cytomegalovirus and mycobacterium species in a patient with acquired immune deficiency syndrome. after debulking, the conjunctival tissue was studied with the use of light and electron microscopy; stains for bacteria, acid-fast bacilli, and bartonella species; and immunohistochemical studies for cytomegalovirus and herpes simplex virus. we observed the t ... | 2004 | 15083089 |
| tenosynovitis caused by mycobacterium kansasii associated with a dog bite. | a 68-year-old man with adult-onset diabetes mellitus suffered an accidental puncture wound to the palm of his hand while playing with his pet dog. he received cephalosporin prophylaxis for 1 week. no inflammation occurred. six months later, a mass developed near his elbow. it was removed. histopathology revealed granulomas containing acid-fast bacilli (afb). no culture was done. swelling and decreased motion of the wrist and fingers developed. magnetic resonance imaging revealed inflammation of ... | 2004 | 15166745 |
| [four cases of mycobacterium xenopi pulmonary disease]. | mycobacterium xenopi is very rare pathogen in japan. we reported herein four cases of m. xenopi pulmonary disease. these patients were all male and their ages ranged from 53 to 72. they all had past history of pulmonary tuberculosis, including two cases who had been also treated for mycobacterium kansasii pulmonary disease later. the bacilli could be cultured in mycobacteria growth indicator tube (mgit) system from 10 sputum samples, but they could not be cultured on ogawa egg media except for t ... | 2004 | 15168439 |
| [a case of infected bulla caused by mycobacterium kansasii]. | a 62-year-old man was referred to our hospital because of persistent sub-fever. a pulmonary fungal infection was suspected owing to the elevation of the serum-d-glucan level. since a chest radiograph and a ct scan revealed intrabullous fluid in the right upper lobe, percutaneous needle aspiration was performed. although acid-fast bacilli smears of the sputum and intrabullous fluid were negative, their cultures were found to be positive thereafter. m. kansasii was isolated and identified. after c ... | 2004 | 15168464 |
| phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria. | we studied the anti-microbial effects of phenoxazines produced by the reaction of o-aminophenol or its derivatives with bovine hemoglobin, on seven species of mycobacteria such as mycobacterium tuberculosis, mycobacterium marinum, mycobacterium intracellulare, mycobacterium scrofulaceum, mycobacterium fortuitum, mycobacterium kansasii and mycobacterium smegmatis and some bacteria such as escherichia coli, pseudomonas aeruginosa, salmonella enterica serovar typhimurium, staphylococcus aureus, lis ... | 2004 | 15185971 |
| incidence and molecular typing of mycobacterium kansasii in a defined geographical area in catalonia, spain. | a retrospective population-based study was conducted between january 1990 and december 1998 to investigate the incidence of mycobacterium kansasji disease and the heterogeneity of the isolates in a well-defined geographical area in catalonia, spain. a total of 136 patients were identified. overall incidence and incidence in aids patients was 1.5 (95% ci 1.2-1.8) and 1089.6 (95% ci 689-1330) cases/100,000 persons per year respectively, which is comparable to that reported from most of other geogr ... | 2004 | 15188712 |
| mortality prediction in pulmonary mycobacterium kansasii infection and human immunodeficiency virus. | in the setting of human immunodeficiency virus (hiv) infection, the clinical implications of american thoracic society (ats) diagnostic criteria and the significance of a single positive respiratory culture for mycobacterium kansasii are unknown. we retrospectively studied hiv-infected patients with pulmonary m. kansasii isolated between 1989 and 2002 at one institution. of 127 patients, 33% fulfilled ats disease criteria. twenty-nine percent received at least three active drugs for at least 3 m ... | 2004 | 15215152 |
| a systematic review of the clinical significance of pulmonary mycobacterium kansasii isolates in hiv infection. | guidelines recommend treating hiv-infected patients with pulmonary mycobacterium kansasii infection only in the presence of multiple positive cultures and clinical and radiographic abnormalities. some authors suggest a single positive culture warrants treatment. a systematic literature review was done to determine whether hiv-infected patients who had m. kansasii isolated from respiratory specimens may have an indolent infection (often referred to as colonization) not requiring treatment and to ... | 2004 | 15220694 |
| comparative evaluation of the new version of the inno-lipa mycobacteria and genotype mycobacterium assays for identification of mycobacterium species from mb/bact liquid cultures artificially inoculated with mycobacterial strains. | the performance of two dna line probe assays, a new version of inno-lipa mycobacteria (innogenetics, ghent, belgium) and the genotype mycobacterium (hain diagnostika, nehren, germany), were evaluated for identification of mycobacterial species isolated from liquid cultures. both tests are based on a pcr technique and designed for simultaneous identification of different mycobacterial species by reverse hybridization and line probe technology. the inno-lipa mycobacteria v2 targeting the 16s-23s r ... | 2004 | 15243064 |
| a new group of potential antituberculotics: hydrochlorides of piperidinylalkyl esters of alkoxy-substituted phenylcarbamic acids. | a group of 31 of alkoxy-substituted phenylcarbamic acids with the alkoxy group in ortho, meta or para position, and methyl or ethoxymethyl attached to the ethylene moiety in position 1, including both basic ethyl esters and derivatives branched on ethylene, were evaluated for in vitro antimycobacterial activity against mycobacterium tuberculosis, m. kansasii, and m. avium. to describe the structure-antimycobacterial activity relationships (qsars), an approach based on a combination of the free-w ... | 2004 | 15259766 |
| antimycobacterial n-pyridinylsalicylamides, isosters of salicylamides. | the series of derivatives of substituted n-pyridinylsalicylamides were synthesized. the compounds were evaluated for in vitro antimycobacterial activity against mycobacterium avium and two strains of mycobacterium kansasii. in the quantitative structure activity relationships analysis (qsar), the free-wilson and hansch approaches were used but the analysis was not significant. (the standard deviations of regression coefficients were greater than the values of the coefficients). the molecules wer ... | 2004 | 15262531 |
| [a case of pulmonary mycobacterium kansasii infection complicated with pleural effusion]. | a 60-year-old man was admitted to our hospital complaining of general malaise for a few months, discomfort of the right shoulder and fever in may 2003. chest x-ray film showed an infiltrative shadow in the right lung field and chest ct scan revealed right pleural effusion. pulmonary tuberculosis complicated with pleurisy was first suspected from the findings of high ada level of the effusion and positive result of ppd skin test. but, microscopic examination of the specimens obtained by transbron ... | 2004 | 15293754 |
| [molecular identification of mycobacteria and detection of antibiotic resistance]. | mycobacteria are responsible for many human infections, especially species of tuberculosis complex, causative agents of tuberculosis. with nine millions new cases every year, this disease is responsible for more than two millions of deaths. nontuberculous mycobacteria (e.g. mycobacterium avium-intracellulare, mycobacterium kansasii, mycobacterium xenopi or mycobacterium ulcerans) can cause infections too, usually in particular clinical settings. standard diagnosis of mycobacterial infections rel ... | 2004 | 15297234 |
| characterization of a trinucleotide repeat sequence (cgg)5 and potential use in restriction fragment length polymorphism typing of mycobacterium tuberculosis. | the genomes of 28 bacterial strains, including mycobacterial species mycobacterium tuberculosis and mycobacterium bovis, were analyzed for the presence of a special class of microsatellite, that of trinucleotide repeat sequences (trs). results of a search of all 10 possible trs motifs (i.e., cct, cgg, ctg, gaa, gat, gta, gtc, gtg, gtt, and tat) with five or more repeating units showed that (cgg)(5) was highly represented within the genomic dna of m. tuberculosis and m. bovis. most of the (cgg)(5 ... | 2004 | 15297495 |
| pneumonia caused by mycobacterium kansasii in a series of patients without recognised immune defect. | the clinical and epidemiological characteristics of 17 patients diagnosed with mycobacterium kansasii pneumonia within a limited geographical region over a period of 10 years are described. an in-depth evaluation of the innate and adaptive immune systems was performed for five available patients. a comparison was made of the genetic fingerprint patterns of the isolates obtained by restriction fragment length polymorphism (rflp) analysis, with the major polymorphic tandem repeat (mptr) as a probe ... | 2004 | 15301677 |
| clinical features of eleven cases of mycobacterium avium-intracellulare complex pulmonary disease associated with pneumoconiosis. | the relationship between silicosis and tuberculosis is well known. also other mycobacteria such as mycobacterium kansasii often occur in association with pneumoconiosis. however, there are few reports describing an association of m. avium-intracellulare complex (mac) lung disease and pneumoconiosis. the purpose of the present study is to describe clinical features of mac respiratory infection associated with pneumoconiosis. eleven patients with mac respiratory infection associated with pneumocon ... | 2004 | 15303635 |
| [clinical evaluation on isolation of mycobacterium kansasii in our hospital]. | we retrospectively evaluated 49 cases from whom mycobacterium kansasii (mk) was isolated from 1992 to 2001 in our hospital. | 2004 | 15354728 |
| nontuberculous mycobacterial infection in children: a 2-year prospective surveillance study in the netherlands. | we performed a prospective, 2-year nationwide study to assess incidence and disease characteristics of suspected infections with nontuberculous mycobacteria (ntm) in children, via the netherlands pediatric surveillance unit. data for 61 children were reported (median age, 31 months; interquartile range, 22-50 months; female sex, 37 subjects); 2 subjects had an underlying disease. most children (53 [87%] of 61) had cervical lymph node enlargement, with abscess in 25 (47%) and fistula in 11 (21%). ... | 2004 | 15356803 |
| bilateral pleural effusions and right pneumothorax in a 25-year-old man. | | 2004 | 15364783 |
| mutant prevention concentration: a new tool for choosing treatment in nontuberculous mycobacterial infections. | the mutant prevention concentration (mpc) of fluoroquinolones, linezolid, rifabutin, rifampicin and macrolides was determined in 16 nontuberculous mycobacterium species in order to compare the incidence of resistant mutant occurrence for different antibiotics. linezolid showed good activity against mycobacterium gordonae and mycobacterium kansasii. rifabutin had a lower mpc values than rifampicin. the fluoroquinolones were more active against m. gordonae and mycobacterium chelonae. clarithromyci ... | 2004 | 15380260 |
| pulmonary alveolar proteinosis associated with psoriasis and complicated by mycobacterial infection: successful treatment with granulocyte-macrophage colony stimulating factor after a partial response to whole lung lavage. | pulmonary alveolar proteinosis (pap) is a rare lung disease. although whole lung lavage is considered the most effective treatment, not every patient shows a complete response. the case ofa young man with pap in association with psoriasis who underwent frequent whole lung lavage but only achieved remission following treatment with granulocyte-macrophage colony stimulating factor (gm-csf) is reported. his lung problem was complicated by atypical mycobacterial infection,which resolved with treatme ... | 2004 | 15497254 |
| [a case of idiopathic bronchiolitis obliterans accompanied with pneumothorax and pulmonary atypical mycobacteriosis]. | a 22-year-old man was urgently admitted for pneumothorax. he continued complaining of exertional dyspnea and dry cough after the pneumothorax healed. about three months later, an atypical pulmonary mycobacteriosis by mycobacterium kansasii was identified. exertional dyspnea increased after chemotherapy was administered, and the patient was readmitted because of difficulty in daily life activities. chest radiographs and ct scans showed bilateral pulmonary hyperinflation and a narrowed heart shado ... | 2004 | 15500153 |
| recurrent multifocal mycobacterium kansasii infection in an immunosuppressed patient with myelodysplasia and relapsing polychondritis. | | 2004 | 15502000 |
| non-tuberculous mycobacteria: patterns of isolation. a multi-country retrospective survey. | to collect data on non-tuberculous mycobacteria (ntm) isolated from clinical laboratories in different countries to establish: 1) whether the isolation of ntm was increasing, 2) which species were increasing, and 3) whether there was any pattern of geographical distribution. | 2004 | 15527150 |
| epidemiological, clinical and therapeutic features of aids-related mycobacterium kansasii infection during the hiv pandemic: an 11-year follow-up study. | optimal diagnosis and timely treatment of atypical mycobacteriosis, and especially mycobacterium kansasii disease, remain a serious challenge for clinicians engaged in the management of the immunocompromised host. | 2004 | 15544696 |
| mycobacterium nebraskense sp. nov., a novel slowly growing scotochromogenic species. | the characterization of a novel slowly growing, scotochromogenic mycobacterium species is reported. this previously undescribed mycobacterial species was isolated from five different patients with symptomatic pulmonary infections. all isolates were acid-fast-positive and the mycolic acid profiles were unique and supported placement into the genus mycobacterium. phenotypic characteristics of each strain included optimal growth after 3 weeks at a temperature range of 30-35 degrees c, yellow pigmen ... | 2004 | 15545434 |
| comparative in vitro activities of linezolid, telithromycin, clarithromycin, levofloxacin, moxifloxacin, and four conventional antimycobacterial drugs against mycobacterium kansasii. | mycobacterium kansasii is one of the most pathogenic and frequent nontuberculous mycobacteria isolated from humans. patients with adverse drug reactions, resistant isolates, or suboptimal response require alternative treatment regimens. one hundred forty-eight consecutive clinical isolates of m. kansasii were tested for antimicrobial susceptibilities by the bactec 460 system (nccls) with two different inoculation protocols, one conventional and one alternative. in the alternative protocol, the i ... | 2004 | 15561826 |
| tenosynovitis of the hands caused by mycobacterium kansasii in a patient with scleroderma. | | 2004 | 15570663 |
| mycobactericidal and tuberculocidal activity of korsolex af, an amine detergent/disinfectant product. | the mycobactericidal and tuberculocidal activities of korsolex af against mycobacterium tuberculosis, mycobacterium avium-mycobacterium intracellulare (mai), mycobacterium kansasii and mycobacterium chelonae were determined using quantitative suspension and carrier tests. the effects of organic load and hard water were also considered. a clinical isolate of mai was the most resistant of the four test organisms. a 2% solution had good mycobactericidal and tuberculocidal activities after 30 min of ... | 2005 | 15571855 |
| mycobacterium kansasii osteomyelitis in a patient with aids on highly active antiretroviral therapy. | skeletal infections with atypical mycobacteria are usually a manifestation of advanced hiv disease with most patients having cd4 counts of less than 100 cells/mm3. we report a case of mycobacterium kansasii vertebral osteomyelitis on highly active antiretroviral therapy with a cd4 count of 320 cells/mm3 and viral load below the level of detection at the onset. | 2004 | 15609709 |
| use of glycopeptidolipid core antigen for serodiagnosis of mycobacterium avium complex pulmonary disease in immunocompetent patients. | we report the development of a serodiagnostic method for mycobacterium avium complex (mac) disease with an enzyme immunoassay (eia) with the mac-specific glycopeptidolipid (gpl) core as the antigen. in this study, we confirmed by eia that the gpl core antibody was in the sera of immunocompetent patients with mac disease. the eia for quantifying the gpl core antibody was evaluated as a clinical tool for serodiagnosis of pulmonary mac disease. a significant increase in gpl core antibodies (immunog ... | 2005 | 15642983 |
| molecular characterization of mycobacterium kansasii isolates in the state of são paulo between 1995-1998. | mycobacterium kansasii is the most common cause of pulmonary nontuberculous mycobacteria infection and classical identification of this pathogen needs a time consuming phenotypic tests. polymerase chain reaction-restriction fragment length polymorphism analysis (pra) of the gene enconding for the 65 kda heat shock (hsp65) protein offers an easy, rapid, and inexpensive procedure to identify and subtype m. kansasii isolates. in the present study, we performed a retrospective analysis of patients w ... | 2004 | 15654431 |
| synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles. | a series of substituted 2-polyfluoroalkyl and 2-nitrobenzylsulphanyl benzimidazoles was synthesized. the compounds were evaluated for their activity against four mycobacterium strains; the activities were expressed as the minimum inhibitory concentration (mic). the substances tested showed appreciable antimycobacterial activity, particularly 5,6-dichloro-2-nonafluorobutylbenzimidazole (2h), and 5-halogeno- (5a-c) and 4,6-dihalogeno- (5d and 5g) 2-(3,5-dinitrobenzylsulphanyl)benzimidazoles, whose ... | 2005 | 15694655 |
| bilateral bronchiectasis and bronchiolitis at thin-section ct: diagnostic implications in nontuberculous mycobacterial pulmonary infection. | to determine frequency of nontuberculous mycobacterial (ntm) pulmonary infection in patients with bilateral bronchiectasis and bronchiolitis at chest computed tomography (ct) and whether ct findings are indicative of mycobacterium avium-intracellulare complex (mac) infection. | 2005 | 15703315 |
| multicenter evaluation of mycobacteria identification by pcr restriction enzyme analysis in laboratories from latin america and the caribbean. | the identification of mycobacterial species in clinical isolates is essential for making patient care decisions. polymerase chain reaction (pcr) restriction enzyme analysis (pra) is a simple and rapid identification method, based on amplification of 441 bp of the hsp65 gene and restriction with bsteii and haeiii. as a contribution to the validation of pra, a multicenter study was performed in eight laboratories located in argentina, brazil, colombia, chile, and guadeloupe. each laboratory receiv ... | 2004 | 15722145 |
| septic monoarthritis of the first carpo-metacarpal joint caused by mycobacterium kansasii. | a case of septic carpal monoarthritis due to mycobacterium kansasii developing 16 months after accidental inoculation in a healthy laboratory technician is reported. no predisposing factor such as immunosuppression, preexisting degenerative, inflammatory arthritis or cortisone injection was present. treatment with antituberculous oral medication alone resulted in resolution of the disease. synovectomy was unnecessary. ten years after the initial causative event, the patient remains free of sympt ... | 2005 | 15754714 |
| the human macrophage mannose receptor is not a professional phagocytic receptor. | the macrophage mannose receptor (mr) appears to play an important role in the binding and phagocytosis of several human pathogens, but its phagocytic property and signaling pathways have been poorly defined. the general strategy to explore such topics is to express the protein of interest in nonphagocytic cells, but in the case of mr, there are few reports using the full-length mr cdna. when we searched to clone de novo the human mr (hmr) cdna, problems were encountered, and full-length hmr cdna ... | 2005 | 15767290 |
| esat-6 and cfp-10 in clinical versus environmental isolates of mycobacterium kansasii. | mycobacterium kansasii consists of 5 genetically distinct groups, of which 2 are associated with human disease. determinants of the differences in virulence are unknown. potential genes of interest are esat-6 and cfp-10, which are associated with virulence of mycobacterium tuberculosis and mycobacterium bovis but are lacking in bacille calmette-guérin and in most environmental mycobacteria (m. kansasii is an exception). we investigated esat-6 and cfp-10 genes in 22 clinical and 14 environmental ... | 2005 | 15776377 |
| [clinical study on development of nontuberculous mycobacterial lung disease]. | developement of mac lung disease: an increase of nodular bronchiectatic type of mac lung disease becomes a problem among respiratory physician today. the reason is still unknown, but it seems to be globally recognized that this type of mac disease is developing particularly in middle-aged woman. some papers mentioned the existence of such type of mac lung disease already early in the 70s, in japan. yamamoto described that 17 cases of middle lobe type lung disease out of 154 non-photochoromogen c ... | 2004 | 15782619 |
| [prevalence of mycobacteriosis and tuberculosis in a reference hospital, cordoba province]. | environmental mycobacteria (em) constitute an important group of bacteria species found in the environment. they can colonize and occasionally produce disease in man. sixteen thousand three hundred samples from 9300 adult symptomatic patients from the hospital regional of tuberculosis in cordoba were bacteriolocally investigated. the isolations were performed by culture on lowenstein jensen and stonebrink culture media. the colonies of acid fast bacilli (afb) were identified by biochemical and m ... | 2004 | 15786869 |
| infected pulmonary sequestration caused by mycobacterium kansasii. | | 2005 | 15790996 |
| in vitro activity of linezolid, clarithromycin and moxifloxacin against clinical isolates of mycobacterium kansasii. | to compare the activity of linezolid with a range of drugs used in the treatment of mycobacterium kansasii infections. | 2005 | 15824090 |
| [clinical and epidemiological study of disease caused by mycobacterium kansasii in the metropolitan area of bilbao, spain]. | epidemiological description of individuals from whom mycobacterium kansasii isolates were obtained in respiratory samples, and analysis of the isolates using molecular biological techniques. | 2005 | 15826528 |
| [phenotypic and genotypic characteristics of mycobacterium kansasii strains isolated in spain (2000-2003)]. | mycobacterium kansasii is an opportunistic pathogen that mainly causes pulmonary infections. this species accounted for 9.7% of mycobacteria other than tuberculosis complex identified in the reference laboratory of the spanish centro nacional de microbiologia during the period of 2000-2003. | 2005 | 15899174 |
| heterocyclic isosters of antimycobacterial salicylanilides. | a series of 64 derivatives of substituted heterocyclic analogues of salicylanilides was synthesized. the compounds were evaluated for in vitro antimycobacterial activity against mycobacterium tuberculosis, mycobacterium avium and two strains of mycobacterium kansasii. for the qsar study, the combination of free-wilson approach with hansch approach was used. the molecules were separated on the heterocyclic and salicyl moieties and the study of influences of electronic and hydrophobic properties w ... | 2005 | 15910812 |
| molecular analyses of mycobacteria other than the m. tuberculosis complex isolated from northern ireland cattle. | mycobacteria other than the mycobacterium tuberculosis complex (mott), isolated from northern ireland cattle, were identified by pcr amplification of the 16s rrna gene, and subsequent reverse cross blot hybridisation and sequence analyses. elucidation of the mott species was to facilitate specificity testing of new and existing diagnostic test reagents for bovine tuberculosis. the presence of the genes for potential diagnostic antigens: mpb70, mpb64, esat-6 and cfp-10 in the isolated mott specie ... | 2005 | 15917138 |
| [pfge analysis of mycobacterium kansasii isolates in okayama prefecture]. | to investigate the epidemiology of m. kansasii infections in okayama prefecture and to consider the mode of infection of m. kansasii on the basis of the pfge results. | 2005 | 15920977 |
| mycobacterium kansasii endobronchial ulcer in a nonimmunocompromised patient. | in this report we describe the case of an immunocompetent patient found to have an endobronchial, ulcerated lesion due to mycobacterium kansasii. predisposing factors could have been severe endobronchial stenosis of the main stem bronchi and distortion of the carina, due to healed endobronchial tuberculosis. diagnosis was set through fiberoptic bronchoscopy and the patient responded well to treatment. endobronchial non tuberculous mycobacterial infection should be considered in both hiv seroposi ... | 2005 | 15942302 |
| granulomatous synovialitis with erosions in the shoulder joint: a rare case of polyarthritis caused by mycobacterium kansasii. | | 2005 | 15958766 |
| [a rare case of disseminated mycobacterium kansasii infection]. | mycobacterium kansasii infection has been reported to be about 20 percent of non-tuberculous mycobacteriosis, and its disseminated type is uncommon and the prognosis is reported to be generally poor. we experienced one case of disseminated mycobacterium kansasii infection. a 81 year-old man who had been short-bowel syndrome due to the operation for superior mesenteric artery occlusion since 1998 was admitted on april 24th, 2001 to our hospital because of slowly progressive consciousness disturba ... | 2005 | 15991601 |
| identification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factors. | diacyl phthiocerol esters and their congeners are mycobacterial virulence factors. the biosynthesis of these complex lipids remains poorly understood. insight into their biosynthesis will aid the development of rationally designed drugs that inhibit their production. in this study, we investigate a biosynthetic step required for diacyl (phenol)phthiocerol ester production, i.e., the reduction of the keto group of (phenol)phthiodiolones. we utilized comparative genomics to identify phthiodiolone ... | 2005 | 15995190 |
| age-related prevalence and distribution of nontuberculous mycobacterial species among patients with cystic fibrosis. | we studied the prevalence and species distribution of nontuberculous mycobacteria (ntm) in relation to age in 385 patients with cystic fibrosis (cf) (mean age +/- standard deviation [range], 12.0 +/- 6.1 [1 to 24] years; sex ratio, 0.53) attending three parisian centers. the overall prevalence of ntm in sputum was 8.1% (31 out of 385). the following ntm were isolated (n = 33): mycobacterium abscessus (n = 13, 39.4%), mycobacterium avium complex (mac) (n = 7, 21.2%), mycobacterium gordonae (n = 6 ... | 2005 | 16000480 |
| [10 years survival of patient with lung cancer and cerebral metastasis]. | the authors describe the case of survival for the period of 10 years after brain metastasis surgery and removal of the left lung upper lobe due to adeno-squamous cells carcinoma. surgery did not generate any complications. within 8 years after the surgery the radiological examination showed infiltrations resembling changes typical for tuberculosis. microbiological analysis showed a culture of mycobacterium kansasi leading to diagnosis of mycobacteriosis. hence the antituberculous treatment was e ... | 2004 | 16022000 |
| clinical features and follow up of 302 patients with mycobacterium kansasii pulmonary infection: a 50 year experience. | to analyse clinical features and treatment outcomes of patients with pulmonary mycobacterium kansasii infection treated at hines va hospital between 1952 and 1995, and followed up until 2003. | 2005 | 16085747 |
| identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol. | systematic thin layer chromatographic (tlc) analysis of apolar lipids in mycobacterium kansasii revealed the presence of a previously uncharacterized novel component. the product was ubiquitously found in a panel of m. kansasii clinical isolates, as well as other pathogenic and non-pathogenic mycobacterial species. tlc analysis of [(14)c]-acetate- or [(14)c]-glycerol-labelled m. kansasii cultures tentatively assigned the novel product as an unusual triacylglycerol-related lipid. subsequent purif ... | 2005 | 16091048 |
| the mimetics of antiadhesive peptides as the inhibitors of mycobacterium kansasii phagocytosis. | the alpha-guanidino acids derived of 15 proteinaceous amino acids, omega-guanidino acids with gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the mimetics of antiadhesive peptides in mycobacteria phagocytosis inhibition. the crystal structure of omega-guanidino acids used was determined by x-ray structural analysis. it follows from our experiments that the proper distance between guanidine and carboxyl groups of effector molecules is of decisive importance for t ... | 2005 | 16112391 |