| selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts. | n-(n-retinoyl)-l-leucyldoxorubicin 14-linoleate (r11-dox), a new lipophilic derivative of doxorubicin, was synthesized and incorporated into low-density lipoprotein (ldl). the drug-ldl complex contained 100-200 drug molecules/ldl particle. when cultured normal human fibroblasts were incubated with 125i-ldl-incorporated drug, there was a perfect correlation between the cellular uptake plus degradation of 125i-ldl and the cellular drug accumulation. the presence of excess native ldl inhibited the ... | 1985 | 3856679 |
| in vitro activity of ci-934, a quinolone carboxylic acid active against gram-positive and -negative bacteria. | ci-934 is a totally synthetic difluorinated quinolinecarboxylic acid with an ethyl-amino-methyl pyrrolidine side chain, which has broad-spectrum antibacterial activity, including particular potency directed against streptococci and staphylococci. the ci-934 mic (micrograms per milliliter) for 90% of the strains tested was 0.4 (range, 0.2 to 0.8) for a group of streptococci (pneumococci, viridans streptococci, streptococcus faecalis, and lancefield groups a, b, and c), 0.2 (0.05 to 0.2) for staph ... | 1985 | 3866513 |
| characterization with monoclonal antibodies of a surface antigen of plasmodium falciparum merozoites. | the merozoite, the extracellular form of the erythrocyte stage of the malarial parasite, invades the erythrocyte and develops intracellularly. cloned hybridoma cell lines secreting monoclonal antibodies directed against the merozoite surface were selected by indirect immunofluorescent assay by using intact isolated merozoites. monoclonal antibodies to a 200,000 m.w. merozoite surface antigen were selected and were used to characterize this protein and its role in erythrocyte invasion. immunoelec ... | 1985 | 3881529 |
| cloning and expression in escherichia coli of vibrio parahaemolyticus thermostable direct hemolysin and thermolabile hemolysin genes. | two hemolysin genes of vibrio parahaemolyticus wp1, a thermostable direct (tsd) hemolysin gene and a thermolabile hemolysin gene, were cloned into the pbr322 vector in escherichia coli k-12 c600. a large amount of the tsd hemolysin produced in e. coli k-12 accumulated in the periplasmic space. the tsd hemolysin gene was localized on a 0.9-kilobase hindiii-bamhi fragment by identifying qualitatively the production of the tsd hemolysin by a reverse passive hemagglutination assay in the osmotic sho ... | 1985 | 3886626 |
| cardioprotective effects of defibrotide in acute myocardial ischemia in the cat. | we investigated the effects of defibrotide (d), a natural polydeoxyribonucleotide, on acute myocardial ischemia (ami) in anesthetized cats. a permanent ligature was placed around the left anterior descending coronary artery (lad) 12-14 mm from its origin. ventricular fibrillation and death were exceptional and when they occurred the cats were not included in the evaluation. pretreatment of cats with d, 32 mg kg-1 h-1, i.v. infusion, maintained throughout the 5 h occlusion period, reduced ami-st ... | 1985 | 3890260 |
| cardioprotective effects of defibrotide in acute myocardial ischemia in the cat. | we investigated the effects of defibrotide (d), a natural polydeoxyribonucleotide, on acute myocardial ischemia (ami) in anesthetized cats. a permanent ligature was placed around the left anterior descending coronary artery (lad) 12-14 mm from its origin. ventricular fibrillation and death were exceptional and when they occurred the cats were not included in the evaluation. pretreatment of cats with d, 32 mg kg-1 h-1, i.v. infusion, maintained throughout the 5 h occlusion period, reduced ami-st ... | 1985 | 3890260 |
| spontaneous vibrio vulnificus peritonitis and primary sepsis in two patients with alcoholic cirrhosis. | two patients with alcoholic cirrhosis were seen on two separate occasions for fever, swollen legs, petechial hemorrhage, purpura, and cutaneous bullae. one patient ate oysters 2 days before the onset of illness. vibrio vulnificus, a lactose-positive halophilic vibrio, was isolated from the ascitic and cutaneous fluid in both cases, and from the blood in one of the two cases. both isolated strains were sensitive to the antibiotics given to the patients from the beginning; however, both patients d ... | 1985 | 3898820 |
| production and partial characterization of an elastolytic protease of vibrio vulnificus. | conditions are described for the production of large amounts of an extracellular elastolytic protease by vibrio vulnificus. the yield of enzyme was maximal during the late exponential growth phase and was stable during the stationary growth phase in a medium composed of 2% proteose peptone and 1.5% nacl. the protease has a molecular weight of ca. 50,500 (estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis), an isoelectric point of ca. 5.8, and a ph optimum range against azocas ... | 1985 | 3902648 |
| identification of vibrio vulnificus by indirect immunofluorescence. | a rapid, sensitive, and specific indirect immunofluorescence (iif) procedure is described for identifying vibrio vulnificus. reference antisera were prepared by vaccinating rabbits with surface antigen preparations of v. vulnificus, and the antisera were examined for the ability to react with and serologically group 85 isolates of v. vulnificus grown in heart infusion broth, and to detect v. vulnificus in tissue specimens from mice experimentally infected with a virulent isolate of the bacterium ... | 1985 | 3905226 |
| location of polar substituents and fatty acyl chains on lipid a precursors from a 3-deoxy-d-manno-octulosonic acid-deficient mutant of salmonella typhimurium. studies by 1h, 13c, and 31p nuclear magnetic resonance. | eight anionic disaccharide precursors of lipid a accumulate at 42 degrees c in 3-deoxy-d-manno-octulosonic acid-deficient temperature-sensitive mutants of salmonella typhimurium. these compounds comprise a series of lipids based on the minimal structure, o-[2-amino-2-deoxy-n2,o3-bis(3-hydroxytetradecanoyl)-beta-d-glucopyranos yl] -(1----6)-2-amino-2-deoxy-n2, o3-bis(3-hydroxytetradecanoyl)-alpha-d-glucopyranose 1,4'- bisphosphate (designated lipid iva) that differ from each other by the presence ... | 1985 | 3905805 |
| location of polar substituents and fatty acyl chains on lipid a precursors from a 3-deoxy-d-manno-octulosonic acid-deficient mutant of salmonella typhimurium. studies by 1h, 13c, and 31p nuclear magnetic resonance. | eight anionic disaccharide precursors of lipid a accumulate at 42 degrees c in 3-deoxy-d-manno-octulosonic acid-deficient temperature-sensitive mutants of salmonella typhimurium. these compounds comprise a series of lipids based on the minimal structure, o-[2-amino-2-deoxy-n2,o3-bis(3-hydroxytetradecanoyl)-beta-d-glucopyranos yl] -(1----6)-2-amino-2-deoxy-n2, o3-bis(3-hydroxytetradecanoyl)-alpha-d-glucopyranose 1,4'- bisphosphate (designated lipid iva) that differ from each other by the presence ... | 1985 | 3905805 |
| mechanism of sbcb-suppression of the recbc-deficiency in postreplication repair in uv-irradiated escherichia coli k-12. | the mechanism by which an sbcb mutation suppresses the deficiency in postreplication repair shown by recb recc mutants of escherichia coli was studied. the presence of an sbcb mutation in uvra recb recc cells increased their resistance to uv radiation. this enhanced resistance was not due to a suppression of the minor deficiency in the repair of dna daughter-strand gaps or to an inhibition of the production of dna double-strand breaks in uv-irradiated uvra recb recc cells; rather, the presence o ... | 1985 | 3911022 |
| [effect of r plasmids on the growth characteristics of shigella sonnei and escherichia coli]. | revealing of growth characteristics in plasmid and plasmid-free strains was studied with the use of two different hosts: e. coli 15-3 and sh. sonnei 11-941 containing conjugative r plasmids differing in the set of the resistance markers. it was shown that the r plasmids had no noticeable effect on the period of the lag phase and the time of the microbial cell generation. it was also shown that the number of the viable cells in separate cultures of the plasmid-free strain of sh. sonnei 11-941 and ... | 1985 | 3911872 |
| rapid microimmunodiffusion method with species-specific antiserum raised to purified antigen for identification of vibrio vulnificus. | an antigen common to vibrio vulnificus strains, designated vva, was purified by ammonium sulfate precipitation, gel filtration, ion-exchange column chromatography, and preparative gel electrophoresis. the molecular weight of vva was 64,000 when estimated by gel filtration and 40,000 when measured by denaturing polyacrylamide gel electrophoresis. antiserum prepared against purified vva (anti-vva serum) did not agglutinate whole cells of v. vulnificus. therefore, vva was considered a possible inte ... | 1985 | 3918072 |
| demonstration of a common antigen in sonicated cells for identification of vibrio vulnificus serotypes. | ouchterlony immunodiffusion of sonicated vibrio vulnificus cells illustrated a single major precipitation line with antiserum prepared from whole cells of the same species. antigenic analysis by two-dimensional immunoelectrophoresis verified the presence of a single dominant precipitation line. tandem two-dimensional immunoelectrophoretic analyses of v. vulnificus antigens from various strains revealed one fused precipitation line of identity. no fused precipitation lines were seen with other vi ... | 1985 | 3918076 |
| the prostaglandin h synthase-dependent activation of 2-aminofluorene to products mutagenic to s. typhimurium strains ta98 and ta98nr. | | 1985 | 3925332 |
| pressure- and temperature-dependent adhesion of pseudomonas aeruginosa to hep-2 cells. | pseudomonas aeruginosa bacteria adhere to human epitheloid (hep-2) cells in culture. under normal atmospheric conditions (1 ata), this adhesion increased significantly when the temperature rose from 22 to 37 degrees c. under hyperbaric atmosphere (= air, 7 ata) conditions, a similar, significant enhancement of bacterial adhesion to the cells was noted when the temperature rose. if the temperature was kept stable at 22 or 37 degrees c and the pressure was increased from 1 to 7 ata, a pressure-ind ... | 1985 | 3925713 |
| synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells. | human umbilical vein endothelial cells were found to contain adrenic acid (22:4) in their cellular lipids. since this fatty acid may be metabolized by cyclooxygenase in the kidney, the metabolism of adrenic acid was studied in endothelial cell cultures. [14c]adrenic acid was metabolized to several more polar metabolites. two of these metabolites co-migrated on hplc with 1 alpha,1 beta-dihomo-8-ketoprostaglandin f1 alpha (the metabolite of 1 alpha, 1 beta-dihomoprostaglandin i2) and 1 alpha,1 bet ... | 1985 | 3931686 |
| de novo expression of t cell markers on theileria parva-transformed lymphoblasts in cattle. | we describe monoclonal antibodies that detect two new membrane antigens on bovine t cells. one molecule is only expressed on activated t cells and has a m.w. of 100,000. the other antigen is a glycoprotein that is precipitated as two bands of m.w. 150,000 and 158,000 and is expressed on a subpopulation of t cells and all myeloid cells. we show that when bovine lymphocytes are transformed by the protozoan parasite theileria parva, both antigens become expressed on the cell surface. the infected c ... | 1985 | 3934278 |
| esculin hydrolysis by vibrio vulnificus. | a clinical isolate of vibrio vulnificus was found to hydrolyze esculin when tested on bile-esculin-azide agar during the initial characterization of the strain. reports in the literature of esculin hydrolysis by v. vulnificus are conflicting. we tested herein 52 strains of v. vulnificus from clinical and environmental sources for the ability to hydrolyze esculin. seventy-eight percent of the strains hydrolyzed esculin on bile-esculin-azide agar, whereas all strains of v. vulnificus tested were p ... | 1986 | 3943291 |
| comparison of particle-associated progesterone and oxytocin in the ovine corpus luteum. | the subcellular distribution of progesterone and oxytocin within the ovine corpus luteum was investigated using differential and density gradient centrifugation. progesterone and oxytocin were associated with particles which sedimented to a density of 1.049-1.054 g/ml and 1.054-1.061 g/ml respectively. particle-associated progesterone did not, however, display physical or biochemical characteristics consistent with its storage within secretory granules. when particle-associated progesterone was ... | 1986 | 3944530 |
| gastroenteritis in patients with stool isolates of vibrio vulnificus. | vibrio vulnificus, a marine vibrio associated with severe extraintestinal infections, has not been previously implicated as a cause of infectious diarrhea. three patients were identified with diarrheal illness from whom this organism was the sole pathogen recovered from cultured stool specimens. all three had eaten raw oysters within one week of becoming ill. these patients were all taking medication that reduces gastric acidity, two were heavy drinkers of alcohol, and one had unrecognized colon ... | 1986 | 3946453 |
| detection of anti-vibrio vulnificus cytolysin antibodies in sera from mice and a human surviving v. vulnificus disease. | an enzyme-linked immunosorbent assay and a cytolysin neutralization assay were used detect anti-vibrio vulnificus cytolysin antibodies in sera from mice and a human that survived v. vulnificus disease. the detection of antibodies against the cytolysin indicated that the cytolysin is produced in vivo, and this observation is consistent with the hypothesis that the cytolysin is involved in the pathogenesis of v. vulnificus disease. | 1986 | 3949387 |
| inland presentation of vibrio vulnificus primary septicemia and necrotizing fasciitis. | | 1986 | 3953073 |
| anal submucosal injection: a new route for drug administration in pelvic malignancies. part i. experimental study of misonidazole distribution in serum and tissues, with special reference to urinary bladder. preliminary report. | the anal and oral administration routes were compared in 30 rats to study the distribution of misonidazole, a radiation sensitizer, in the serum and tissues with special reference to the urinary bladder. 14c-labelled misonidazole was administered in a dose of 0.2 ml water/100 gm body weight containing 1 mu ci misonidazole. the dose was given orally by stomach tube in 15 rats, and was injected in the submucosa of the anal canal in another 15. animals were then killed after 15, 30, 60, or 120 minu ... | 1986 | 3957602 |
| emergence of bactericidal and opsonizing antibody to vibrio vulnificus following bacterial infection. | virulent isolates of vibrio vulnificus resist the bactericidal and opsonizing effects of normal human serum, in contrast to environmental isolates, which are highly serum susceptible. immune responses to bacteremic v. vulnificus infections in human subjects have not been characterized. serum from a patient who survived sepsis caused by v. vulnificus had substantial bactericidal and opsonizing immunoglobulin g (igg) for his own bloodstream isolate. killing was mediated by the classical complement ... | 1986 | 3958138 |
| antibiotic therapy for vibrio vulnificus infection. | | 1985 | 3968842 |
| vibrio vulnificus revisited. | | 1985 | 3969801 |
| purification and characterization of an extracellular cytolysin produced by vibrio vulnificus. | an extracellular cytolytic toxin produced by the halophilic bacterium vibrio vulnificus was isolated free of detectable contamination with medium constituents and other bacterial products by sequential ammonium sulfate precipitation, gel filtration with sephadex g-75, hydrophobic interaction chromatography with phenyl-sepharose cl-4b, and isoelectric focusing in an ethylene glycol density gradient. the cytolysin is a heat-labile, hydrophobic protein that is inhibited by large amounts of choleste ... | 1985 | 3980095 |
| metastatic nontraumatic clostridium septicum osteomyelitis. | nontraumatic clostridial infections are rare, but need to be diagnosed and treated early or high morbidity and mortality rates result. we believe that this is the first reported case of metastatic nontraumatic clostridium septicum osteomyelitis. early treatment with surgical debridement and parenteral antibiotics without hyperbaric oxygen was used. an associated occult rectal malignancy was discovered and treated. | 1985 | 3980945 |
| molecular mechanisms of olfactory reception. vi. kinetic characteristics of camphor interaction with binding sites of rat olfactory epithelium. | camphor binding to a possible receptor of rat olfactory epithelium has been studied within the ligand concentration range 10(-11)-10(-6) m. at these concentrations camphor is bound by a set of receptors. they are distinguished by both the affinity to the ligand (k1 = 5 x 10(-10) m, k2 = 3.5 x 10(-8) m, k3 approximately equal to 10(-6) m) and their amount in the epithelium. the differences in the affinities are due to different values of the association rate constant of camphor (k1), which varies ... | 1985 | 3986222 |
| vibrio vulnificus. man and the sea. | to identify risk factors for vibrio vulnificus infections, we performed a regional case-control study of 19 patients identified by isolates received at a state reference laboratory. interviews with patients or surviving relatives and with three controls for each patient were compared in a matched analysis. patients with v vulnificus wound infection were more likely than controls to have sustained a puncture wound while handling fresh seafood or to have been exposed to salt water. more patients w ... | 1985 | 3989959 |
| [persistent chlamydia infection in cell culture]. | | 1985 | 3993192 |
| vibrio vulnificus and patients with liver disease. | | 1985 | 3996803 |
| fatal septicaemia due to vibrio vulnificus. | | 1985 | 4002991 |
| surgical treatment for infective endocarditis--decision tree for the treatment and introduction of translocation method. | persistent fever during active-phase ie is an indication for surgical treatment in the light of the causative organism and the underlying disease. to counter worsening hemodynamics, surgery may be the only feasible way. surgery is performed when the patient does not respond to vasodilators and he shows an fs of less than 25%. the introduction of translocation provides a solution for the treatment of active ie. lesions, vegetations more than 5 mm in diameter, periannular abscess, and mycotic aneu ... | 1985 | 4021068 |
| topographic organization of projections from the amygdala to the hypothalamus of the rat. | afferent fibers from the amygdala to subdivisions of lateral, ventromedial and dorsomedial hypothalamic nuclei were investigated in rat by retrograde transport of horseradish peroxidase. small (intranuclear size) peroxidase deposits were placed in hypothalamic nuclei by iontophoresis of a tracer solution containing poly-l-alpha-ornithine which greatly limited diffusion. the medial, central and amygdalo-hippocampal nuclei of the amygdala were found to be the major donors of amygdaloid afferent fi ... | 1985 | 4022458 |
| detection of reticulo-endothelial blockade with low-dose test agent. | blood clearance and organ extraction of a low-dose reticulo-endothelial test agent, technetium labelled tin colloid (ttc), was measured in groups of rabbits pretreated with reticulo-endothelial blocking agents. electron microscopy and ultrastructure analysis confirmed that kupffer cells extracted ttc. pretreatment with silica caused reduced kupffer cell uptake and spillover of ttc into the spleen. pretreatment with sheep red cells caused reduced kupffer cell uptake and reduced splenic uptake but ... | 1985 | 4027180 |
| vibrio vulnificus resists phagocytosis in the absence of serum opsonins. | invasive disease caused by vibrio vulnificus may result partially from resistance to phagocytic host defense mechanisms. the present studies show that v. vulnificus resists phagocytosis by murine peritoneal macrophages in the absence of serum opsonins and extracellular bacterial products, apparently through the anti-phagocytic properties of the bacterial surface. | 1985 | 4030101 |
| the incidence of rhodococcus (corynebacterium) equi in domestic animals and soil. | | 1985 | 4032938 |
| the early revascularization of membranous bone. | the experimental finding that membranous onlay bone grafts maintain volume and viability to a greater extent than do endochondral grafts may be related to the more rapid vascularization of membranous bone. microangiographic techniques were used to study the rates of vascularization of membranous and endochondral bone grafts in adult white new zealand rabbits at 1, 3, 7, 14, and 21 days after bone grafting. vascularization patterns were quantified microscopically using a modified point-counting t ... | 1985 | 4034769 |
| vibrio vulnificus septicemia. | a 33-year-old japanese male, who had a three year history of biopsy-proved liver cirrhosis, was admitted to the hospital on june, 24, 1983 with a sudden onset of fever (38.6 degrees c), chills, generalized pain, nausea, anorexia, weakness, and eruption over the entire body. the patient went into shock and died about 7 hours after admission. blood cultures before death were positive for v. vulnificus. postmortem microscopic examination revealed "necrotizing vasculitis" in the small and large inte ... | 1985 | 4036604 |
| the effects of hypolipidaemic benzodiazepines on serum lipoproteins in hyperlipidaemic rats. | | 1985 | 4037206 |
| vibrio vulnificus in sea water: a possible cause of acute diarrhea in man? | | 1985 | 4038051 |
| inhibition of lipases by proteins. a kinetic study with dicaprin monolayers. | we report further investigations on protein inhibition of pancreatic and microbial lipases carried out with the monolayer technique. when beta-lactoglobulin a, melittin, serum albumin, myoglobin, and a protein inhibiting lipase from soybean were preincubated with a dicaprin film at a surface pressure of 35 dynes/cm, no activity was detected with horse pancreatic or rhizopus delemar lipases. by contrast, rhizopus arrhizus and geotrichum candidum lipase activities were not impaired under the same ... | 1985 | 4038705 |
| local cerebral glucose utilization in normal female rats: variations during the estrous cycle and comparison with males. | the quantitative 2-[14c]deoxyglucose autoradiographic method was used to study the fluctuations of energy metabolism in discrete brain regions of female rats during the estrous cycle. a consistent though statistically nonsignificant cyclic variation in average glucose utilization of the brain as a whole was observed. highest levels of glucose utilization occurred during proestrus and metestrus, whereas lower rates were found during estrus and diestrus. statistically significant fluctuations were ... | 1985 | 4040921 |
| aryl hydrocarbon hydroxylase induction in adult rat hepatocytes in primary culture by several chlorinated aromatic hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin. | the induction of aryl hydrocarbon hydroxylase (ahh) by aroclor 1254, 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) and other polychlorinated organic compounds was examined in primary cultures of adult rat hepatocytes isolated by a collagenase perfusion technique. following exposure of fresh hepatocyte cultures to 1 microgram/ml aroclor 1254, ahh induction was undetected for 48 hr and then increased dramatically up to 96 hr. cultures maintained in control medium for either 24, 48, or 72 hr prior to ... | 1985 | 4043593 |
| treatment of local complications of bcg vaccination. | | 1985 | 4049527 |
| antiarrhythmic and electrophysiologic actions of clofilium in experimental canine models. | clofilium was studied in three experimental models. in non-ischemic and chronically infarcted canine hearts, clofilium (0.5-2 mg/kg) produced a dose-dependent increase in electrical ventricular fibrillation threshold (vft), but prolonged the effective refractory period (erp) of normal myocardium in only the non-ischemic heart. when chronically infarcted hearts were subjected to programmed electrical stimulation, 1 mg/kg of clofilium inhibited the re-induction of either ventricular tachycardia or ... | 1985 | 4054216 |
| characterization of a mitochondrial transport system for branched chain alpha-keto acids. | efflux of branched chain alpha-keto acids from preloaded rat heart mitochondria was slow at low external ph. efflux was first order, and measured rate constants, kappa efflux, were 0.104 +/- 0.005 and 0.115 +/- 0.006 min-1 for alpha-ketoisovalerate and alpha-ketoisocaproate (kic), respectively. efflux was stimulated significantly by branched chain alpha-keto acids and related carboxylates such as alpha-ketocaproate and alpha-ketovalerate, but not by substrates for the pyruvate transporter. kic w ... | 1985 | 4055776 |
| comparison of api 20e, api rapid e, and api rapid nft for identification of members of the family vibrionaceae. | sixty isolates, from nine species of the family vibrionaceae, were tested by the api 20e, api rapid e, and api rapid nft systems. results were compared with those obtained with standard biochemicals. included were 7 aeromonas caviae isolates, 27 aeromonas hydrophilia isolates, 10 aeromonas sobria isolates, 3 plesiomonas shigelloides isolates, 3 vibrio alginolyticus isolates, 3 vibrio cholerae isolates, 1 vibrio fluvialis isolate, 5 vibrio parahaemolyticus isolates, and 1 vibrio vulnificus isolat ... | 1985 | 4056003 |
| [scintillation assay for evaluating chemosensitivities of human tumors--the basic principle and clinical utility]. | | 1985 | 4056552 |
| cloning of the cytotoxin-hemolysin gene of vibrio vulnificus. | genes encoding the cytotoxin-hemolysin of vibrio vulnificus were cloned in escherichia coli by using the lytic cloning vector, lambda 1059. subcloning in plasmid pbr325 resulted in the isolation of a 3.2-kilobase dna fragment containing the cytotoxin gene. by using this fragment as a dna probe, homologous gene sequences were detected in all 54 v. vulnificus strains studied; homologous sequences were present in none of 96 isolates from 29 other bacterial species. | 1985 | 4066036 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 50-1985. a 41-year-old man with diffuse tracheal narrowing. | | 1985 | 4069162 |
| some properties of vibrio vulnificus hemolysin. | some properties of hemolysin produced by vibrio vulnificus were investigated. the hemolysin was heat labile, and the hemolytic activity was inhibited by adding cholesterol or divalent cations. cholesterol inhibited the temperature-independent hemolysin-binding step, suggesting that cholesterol made up the binding site of the cell membrane, whereas the divalent cations inhibited the temperature-dependent membrane-degradation step. however, the v. vulnificus hemolysin was stable to oxygen and sulf ... | 1985 | 4088099 |
| uptake and clearance of vibrio vulnificus from gulf coast oysters (crassostrea virginica). | oysters collected in late winter, when they were free of vibrio vulnificus, were exposed in the organism in the laboratory. the oysters effectively concentrated the bacteria from seawater, but when the inoculum was removed, the bacteria were rapidly cleared from the oyster tissues. these results suggest that v. vulnificus may be found in oysters as a result of filtration of the bacteria from seawater rather than active multiplication of the bacteria in the oysters. | 1985 | 4091570 |
| [peroxidation of unsaturated fatty acid esters injected into rats following x-irradiation]. | | 1971 | 4107884 |
| [peroxidation of unsaturated fatty acid esters injected into rats following x-irradiation]. | | 1971 | 4107884 |
| histamine release during orthotopic homologous liver transplantation in pigs. | | 1973 | 4119938 |
| effect of non-narcotic analgesics on anticoagulant-induced hypoprothrombinemia in rats. | | 1972 | 4120193 |
| antigenic determinants in the n-terminal part of bovine encephalitogenic protein studied with the macrophage migration inhibition assay in guinea pigs. evidence for an immunological reactivity of peptide 1-43 when tested on cells from animals injected with freunds's complete adjuvant. | | 1973 | 4125507 |
| antenatal genetic diagnosis in a kindred with a 15p plus chromosome. | | 1973 | 4132613 |
| biophysical studies on the mechanism of quinacrine staining of chromosomes. | | 1974 | 4135372 |
| high-resolution analysis of the modified quarter-stagger model of the collagen fibril. | | 1974 | 4136772 |
| action of some antibiotics on the electrical activity of intestinal smooth muscle of rat. | | 1973 | 4139937 |
| inhibition of gamma-glutamylcysteine synthetase by l-methionine-s-sulfoximine. | | 1973 | 4147652 |
| proceedings: influence of different metabolic conditions on the affinity of alpha- and beta-sympathomimetic drugs on the rabbit aortic strip. | | 1974 | 4152369 |
| [influence of sodium restitution on tyramine induced catecholamine liberation in auricules previously suspended in a sodium deficient medium]. | | 1970 | 4154730 |
| studies on the oral administration of saliva-parotin-a. iv. oral and intraintestinal administration of 131-i-labelled saliva-parotin-a to rats. | | 1966 | 4166044 |
| pyrrolid-2-one-5 carboxylic acid involvement in the biosynthesis of rabbit immunoglobulin. | | 1967 | 4169559 |
| do viruses cause cancer in man? | | 1968 | 4171855 |
| human serum interactions with candida albicans. | | 1968 | 4173934 |
| structures associated with leptospires possibly relevant to the marburg agent. | | 1969 | 4178592 |
| the glomerular filtration rate during moderate hyperglycemia in normal man. | | 1973 | 4199388 |
| neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. | | 1973 | 4202280 |
| gonococcal conjunctivitis. | | 1974 | 4205793 |
| errors in dna replication in bacteria in the presence of a thymidylic acid deficiency. | | 1974 | 4214996 |
| (na+,k+)-atpase activity in a preparation from human post-mortem myocardium. | | 1970 | 4246164 |
| biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. | | 1970 | 4246573 |
| antibody to adenosine triphosphatase from membranes of micrococcus lysodeikticus. | | 1970 | 4248810 |
| [effect of cyclohexylamine on noradrenaline uptake and the noradrenaline content of rat heart]. | | 1970 | 4249230 |
| [mosaic of g-g translocation observed in a girl with faint symptoms of mongolism]. | | 1971 | 4257569 |
| the inotropic effects of digoxin in hyperkalemia. relation to (na+,k+)-atpase inhibition in the intact animal. | | 1973 | 4270387 |
| [epizootology of leptospirosis]. | | 1973 | 4271210 |
| a simplified procedure for large scale preparation of purified animal dna-dependent rna polymerase. | | 1973 | 4272304 |
| gonococcal antibiotic resistance in los angeles. | one hundred and thirty-five gonococcal isolates collected from los angeles in 1972 were studied for antibiotic susceptibility to penicillin, ampicillin, carbenicillin, tetracycline, minocycline, doxycycline and spectinomycin. only 12 percent of the isolates were sensitive to 0.05 mug per ml of penicillin while 35 percent required at least 0.5 mug per ml for inhibition of growth. the results were slightly better with ampicillin and nearly the same with carbenicillin. nineteen percent of the isola ... | 1974 | 4276887 |
| cardiovascular effects of various agents on cardiogenic shock. | | 1974 | 4279996 |
| dimeric and tetrameric phosphofructokinase and the pasteur effect in escherichia coli k-12. | | 1974 | 4280359 |
| dimeric and tetrameric phosphofructokinase and the pasteur effect in escherichia coli k-12. | | 1974 | 4280359 |
| the response of the pituitary-adrenal system to a stressful stimulus: the effect of conditioning and pentobarbitone treatment. | | 1965 | 4284301 |
| histochemical study on the paneth cell in the rat. | | 1966 | 4285982 |
| histochemical study on the paneth cell in the rat. | | 1966 | 4285982 |
| infection of cattle with parainfluenza 3 virus with special reference to udder infection. i. virus isolation from milk. | | 1966 | 4290964 |
| infection of cattle with parainfluenza 3 virus with special reference to udder infection. i. virus isolation from milk. | | 1966 | 4290964 |
| pituitary acth content in rats after partial or total interruption of neural afferents to the medial basal hypothalamus. | | 1967 | 4292490 |
| pituitary acth content in rats after partial or total interruption of neural afferents to the medial basal hypothalamus. | | 1967 | 4292490 |
| characterization of five isolates of marek's disease. | | 1967 | 4294256 |
| characterization of five isolates of marek's disease. | | 1967 | 4294256 |
| inhibition of fatty acid stimulation of gluconeogenesis by (+)-decanoylcarnitine in perfused rat liver. | | 1968 | 4296238 |
| [extreme hyperthermia studies on 4 different tumors in rats]. | | 1967 | 4299395 |